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Journal of Sexual Medicine

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https://www.readbyqxmd.com/read/27915076/men-presenting-with-sexual-thoughts-of-children-or-coercion-flights-of-fancy-or-plans-for-crime
#1
Tamara Turner-Moore, Mitch Waterman
INTRODUCTION: There is limited evaluation of clinical and theoretical claims that sexual thoughts of children and coercing others facilitate sexual offending. The nature of these thoughts (what they contain) also is unknown. AIM: To examine the relation between child or coercive sexual thoughts and sexual offending and to determine the nature of these thoughts and any differences among sexual offending (SO), non-sexual offending (NSO), and non-offending (NO) men...
November 30, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27717790/development-of-the-hypogonadism-impact-of-symptoms-questionnaire-short-form-qualitative-research
#2
Heather L Gelhorn, Amit R Bodhani, Louisa S Wahala, Chris Sexton, Amanda Landrian, Michael G Miller, Leonard Derogatis, Adrian Dobs, Dennis A Revicki
INTRODUCTION: Hypogonadism in men is often associated with poor libido, erectile dysfunction, irritability, fatigue, and psychological and relationship problems. Many of these symptoms can be best assessed through patient report. The 28-item Hypogonadism Impact of Symptoms Questionnaire (HIS-Q) was developed to evaluate hypogonadism symptoms in men with low testosterone in the context of clinical trials. AIM: To develop a briefer version of the HIS-Q that could be practical for use in treatment settings...
October 4, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27693265/differential-effects-of-cyproterone-acetate-vs-spironolactone-on-serum-high-density-lipoprotein-and-prolactin-concentrations-in-the-hormonal-treatment-of-transgender-women
#3
Raymond Fung, Miriam Hellstern-Layefsky, Camille Tastenhoye, Iliana Lega, Leah Steele
INTRODUCTION: Spironolactone and cyproterone acetate (CPA) are the two main antiandrogen medications used in feminizing hormone therapy in transgender women. Previous studies have suggested that these two agents might have opposite effects on high-density lipoprotein (HDL) level when used in this context, and limited data have suggested CPA increases prolactin more than spironolactone. AIM: To compare the effects of spironolactone and CPA on HDL and prolactin serum concentrations in transgender women...
September 29, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27692845/psychometric-evaluation-of-the-hypogonadism-impact-of-symptoms-questionnaire
#4
Heather L Gelhorn, Ebony Dashiell-Aje, Michael G Miller, Leonard R DeRogatis, Adrian Dobs, Allen D Seftel, Stanley E Althof, Meryl Brod, Dennis A Revicki
INTRODUCTION: The Hypogonadism Impact of Symptoms Questionnaire (HIS-Q) is a patient-reported outcome measurement designed to comprehensively evaluate the symptoms of hypogonadism and to detect changes in these symptoms in response to treatment. AIM: To conduct item analysis and reduction, evaluate the psychometric properties of the HIS-Q, and provide guidance on interpreting the instrument score. METHODS: A 12-week observational, longitudinal study of hypogonadal men was conducted...
September 27, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27686697/patient-discussion-about-sexual-health-with-health-care-providers-after%C3%A2-cancer-a-national-survey
#5
Ali Ben Charif, Anne-Déborah Bouhnik, Blandine Courbiere, Dominique Rey, Marie Préau, Marc-Karim Bendiane, Patrick Peretti-Watel, Julien Mancini
INTRODUCTION: A discussion about sexuality should become a routine part of the personalized care pathway for patients with cancer. AIM: To assess rates of patient discussion about sexuality with health care providers after cancer. METHODS: We used data from the representative French nationwide 2012 VICAN survey, which included 4,349 adults 18 to 82 years old who were still alive 2 years after diagnosis at 12 cancer sites. MAIN OUTCOME MEASURES: Self-reported rates of discussion about sexuality with health care providers were assessed, and associated factors were tested after systematic adjustment for a sexual health indicator (created from six items of the Relationship and Sexuality Scale)...
September 26, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27671969/incidence-of-venous-thromboembolism-in-transgender-women-receiving-oral-estradiol
#6
Justin D Arnold, Eleanor P Sarkodie, Megan E Coleman, Deborah A Goldstein
INTRODUCTION: One of the most serious known adverse effects of feminizing cross-sex hormone therapy (CSHT) is venous thromboembolism (VTE); however, no study has assessed the incidence of VTE from the hormone therapies used in the United States because previous publications on this topic have originated in Europe. CSHT in the United States typically includes estradiol with the antiandrogen spironolactone, whereas in Europe estradiol is prescribed with the progestin cyproterone acetate...
September 23, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914566/free-flap-phalloplasty-for-female-to-male-gender-dysphoria
#7
Giulio Garaffa, David J Ralph
The Surgical Techniques Section is sponsored in part by Coloplast.
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914565/response-and-rebuttal-to-editorial-comment-on-tx-004hr-improves-sexual-function-as-measured-by-the-female-sexual-function-index-in%C3%A2-postmenopausal-women-with-vulvar-and-vaginal-atrophy-the%C3%A2-rejoice%C3%A2-trial
#8
Sheryl A Kingsberg, Leonard Derogatis, James A Simon, Ginger D Constantine, Shelli Graham, Brian Bernick, Gina Gasper, Sebastian Mirkin
No abstract text is available yet for this article.
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914564/editorial-comment-on-tx-004hr-improves-sexual-function-as-measured-by-the-female-sexual-function-index-in-postmenopausal-women-with-vulvar-and-vaginal-atrophy-the-rejoice-trial
#9
https://www.readbyqxmd.com/read/27914563/differential-effects-of-testosterone-and-estradiol-on-clitoral-function-an-experimental-study-in-rats
#10
Paolo Comeglio, Ilaria Cellai, Sandra Filippi, Chiara Corno, Francesca Corcetto, Annamaria Morelli, Elena Maneschi, Elisa Maseroli, Edoardo Mannucci, Massimiliano Fambrini, Mario Maggi, Linda Vignozzi
INTRODUCTION: Female sexual response is a complex phenomenon in which psychological, neurologic, and vascular mechanisms and hormonal factors interact. During the arousal phase, they cooperate to increase genital blood flow, thus inducing engorgement of the clitoris and lubrication of the vagina. Regulation of vascular and non-vascular smooth muscle tone is the crucial event in the erectile process. Preclinical studies have suggested that nitric oxide (NO) is the main vasodilator neurotransmitter modulating, through the second messenger cyclic guanosine monophosphate (cGMP), clitoral flow vessels...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914562/standards-for-clinical-trials-in-male-and-female-sexual-dysfunction-ii-patient-reported-outcome-measures
#11
William A Fisher, Ilan Gruenwald, Emmanuele A Jannini, Ahinoam Lev-Sagie, Lior Lowenstein, Robert E Pyke, Yakov Reisman, Dennis A Revicki, Eusebio Rubio-Aurioles
The second article in this series, Standards for Clinical Trials in Male and Female Sexual Dysfunction, focuses on measurement of patient-reported outcomes (PROs). Together with the design of appropriate phase I to phase IV clinical trials, the development, validation, choice, and implementation of valid PRO measurements-the focus of the present article-form the foundation of research on treatments for male and female sexual dysfunctions. PRO measurements are assessments of any aspect of a patient's health status that come directly from the patient (ie, without the interpretation of the patient's responses by a physician or anyone else)...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914561/standards-for-clinical-trials-in-male-and-female-sexual-dysfunction-i-%C3%A2-phase-i-to-phase-iv-clinical-trial-design
#12
William A Fisher, Ilan Gruenwald, Emmanuele A Jannini, Ahinoam Lev-Sagie, Lior Lowenstein, Robert E Pyke, Yakov Reisman, Dennis A Revicki, Eusebio Rubio-Aurioles
This series of articles outlines standards for clinical trials of treatments for male and female sexual dysfunctions, with a focus on research design and patient-reported outcome assessment. These articles consist of revision, updating, and integration of articles on standards for clinical trials in male and female sexual dysfunction from the 2010 International Consultation on Sexual Medicine developed by the authors as part of the 2015 International Consultation on Sexual Medicine. We are guided in this effort by several principles...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914560/diagnosis-and-treatment-of-testosterone-deficiency-recommendations-from-the-fourth-international-consultation-for-sexual-medicine-icsm%C3%A2-2015
#13
Mohit Khera, Ganesh Adaikan, Jacques Buvat, Serge Carrier, Amr El-Meliegy, Kostas Hatzimouratidis, Andrew McCullough, Abraham Morgentaler, Luiz Otavio Torres, Andrea Salonia
INTRODUCTION: Testosterone deficiency (TD), also known as hypogonadism, is a condition affecting a substantial proportion of men as they age. The diagnosis and management of TD can be challenging and clinicians should be aware of the current literature on this condition. AIM: To review the available literature concerning the diagnosis and management of TD and to provide clinically relevant recommendations from the Fourth International Consultation for Sexual Medicine (ICSM) meeting...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27864032/%C3%AE-1a-adrenergic-receptor-antagonism-improves-erectile-and-cavernosal-responses-in-rats-with-cavernous-nerve-injury-and-enhances-neurogenic-responses-in-human-corpus-cavernosum-from-patients-with%C3%A2-erectile-dysfunction-secondary-to-radical-prostatectomy
#14
Juan I Martínez-Salamanca, José M La Fuente, Eduardo Martínez-Salamanca, Argentina Fernández, Augusto J Pepe-Cardoso, Nuno Louro, Joaquín Carballido, Javier Angulo
INTRODUCTION: Cavernous nerve injury (CNI) in rats and radical prostatectomy (RP) in men result in loss of nitrergic function and increased adrenergic-neurogenic contractions of cavernosal tissue. AIM: To evaluate the modulation of the α-adrenergic system as a strategy to relieve erectile dysfunction (ED) and functional cavernosal alterations induced by CNI. METHODS: A non-selective α-blocker (phentolamine 1 mg/kg daily), a selective α1A-blocker (silodosin [SILOD] 0...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27864031/fractional-co2-laser-treatment-of-the-vestibule-for-patients-with-vestibulodynia-and-genitourinary-syndrome-of-menopause-a-pilot-study
#15
Filippo Murina, Mickey Karram, Stefano Salvatore, Raffaele Felice
INTRODUCTION: Chronic vulvar pain and burning remains one of the most perplexing problems faced by practicing gynecologists. AIM: To evaluate the effectiveness and safety of the application of micro-ablative fractional CO2 laser to the vulvar vestibule in the management of patients with vulvar pain from vestibulodynia or genitourinary syndrome of menopause. METHODS: Patients (N = 70) underwent fractional micro-ablative CO2 laser treatment for vestibular pain plus vestibulodynia (n = 37) or genitourinary syndrome of menopause (n = 33)...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27843074/testosterone-threshold-for-increased-cardiovascular-risk-in-middle-aged-and-elderly-men-a-locally-weighted-regression-analysis
#16
Pin-Wen Liao, Chia-Chang Wu, Kuan-Chou Chen, Fu-Shan Jaw, Hong-Jeng Yu, Shih-Ping Liu, Chen-Hsun Ho
INTRODUCTION: Although testosterone deficiency has a well-known association with increased risk of cardiovascular disease (CVD), the threshold remains to be determined. AIM: To investigate whether there is a discriminatory testosterone level below which the CVD risk increases. METHODS: The study included 876 men 45 to 74 years old who underwent a general health checkup. The Framingham Risk Score was used to estimate the 10-year CVD risk; a high-sensitivity C-reactive protein (hsCRP) level of at least 1 mg/L was considered an indicator of increased CVD risk...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27843073/off-target-effect-of-sildenafil-on-postsurgical-erectile-dysfunction-alternate-pathways-and-localized-delivery-system
#17
Amirali Salmasi, Geun Taek Lee, Neal Patel, Ritu Goyal, Michael Dinizo, Young Suk Kwon, Part K Modi, Izak Faiena, Hee-Jin Kim, Nara Lee, Johanna L Hannan, Joachim Kohn, Isaac Yi Kim
INTRODUCTION: There is no consensus on the best oral phosphodiesterase type 5 inhibitor (PDE5I) for patients undergoing penile rehabilitation after surgical nerve injury. AIM: To determine the mechanism of PDE5I on cultured neuronal cells and the effectiveness of local drug delivery using nanospheres (NSPs) to sites of nerve injury in a rat model of bilateral cavernous nerve injury (BCNI). METHODS: The effects of sildenafil, tadalafil, and vardenafil on cyclic adenosine monophosphate, cyclic guanosine monophosphate, and cell survival after exposure to hypoxia and H2O2 were measured in PC12, SH-SY5Y, and NTERA-2 (NT2) cell cultures...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27843072/toward-a-more-evidence-based-nosology-and-nomenclature-for-female-sexual-dysfunctions-part-ii
#18
Sharon J Parish, Andrew T Goldstein, Sue W Goldstein, Irwin Goldstein, James Pfaus, Anita H Clayton, Annamaria Giraldi, James A Simon, Stanley E Althof, Gloria Bachmann, Barry Komisaruk, Roy Levin, Susan Kellogg Spadt, Sheryl A Kingsberg, Michael A Perelman, Marcel D Waldinger, Beverly Whipple
INTRODUCTION: Current Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) definitions of sexual dysfunction do not identify all sexual problems experienced clinically by women and are not necessarily applicable for biologic or biopsychosocial management of female sexual dysfunction. A unified nomenclature system enables clinicians, researchers, and regulatory agencies to use the same language and criteria for determining clinical end points, assessing research results, and managing patients...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27843071/the-seduction-of-p-values
#19
Christian J Nelson, Elizabeth Schofield
No abstract text is available yet for this article.
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27840129/predatory-journals-illegitimate-publishing-and-its-threat-to-all-readers-and-authors
#20
Jason Roberts
No abstract text is available yet for this article.
December 2016: Journal of Sexual Medicine
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