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Journal of Sexual Medicine

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https://www.readbyqxmd.com/read/30446474/prospective-cohort-of-deep-dyspareunia-in-an-interdisciplinary-setting
#1
Paul J Yong, Christina Williams, Sonja Bodmer-Roy, Chukwuemeka Ezeigwe, Sean Zhu, Kristina Arion, Kristin Ambacher, Ali Yosef, Fontayne Wong, Heather Noga, Susannah Britnell, Holly Yager, Mohamed A Bedaiwy, Lori A Brotto, Arianne Y Albert, Sarka Lisonkova, Catherine Allaire
INTRODUCTION: Deep dyspareunia is a common symptom in women, including in half of women with endometriosis, but little is known about its response to treatment and predictors of persistent deep dyspareunia over time. AIM: To follow up deep dyspareunia severity over a 1-year prospective cohort at an interdisciplinary center, and to identify baseline predictors of more persistent deep dyspareunia at 1 year. METHODS: Prospective 1-year cohort study at a tertiary referral center for pelvic pain and endometriosis, where a range of interdisciplinary treatments are provided at a single center (surgical, hormonal, physical, and psychological therapies)...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30446473/complications-of-genital-enlargement-surgery
#2
James Furr, Kristi Hebert, Eric Wisenbaugh, Joel Gelman
INTRODUCTION: The objective of genital enlargement surgery is to increase length and/or girth for cosmetic reasons; however, newer techniques have been recently reported to be associated with only minor complications in a small percentage of patients. AIM: We aim to report the severe complications of penile augmentation surgery seen at a referral center and describe their subsequent management. METHODS: Institutional review board approval was obtained...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30446472/structure-of-epithelial-and-stromal-compartments-of-vulvar-and-vaginal-tissue-from-women-with-vulvo-vaginal-atrophy-taking-ospemifene
#3
Stefania Alvisi, Maurizio Baldassarre, Giulia Gava, Ilaria Mancini, Martina Gagliardi, Renato Seracchioli, Maria Cristina Meriggiola
INTRODUCTION: Vulvo-vaginal atrophy affects the daily lives of most post-menopausal women. We know that ospemifene intake can induce vaginal epithelial improvements within a few weeks; however, direct evidence of the effects of ospemifene on the human vulva and on connective tissue of both the vagina and vulva are lacking. AIM: To evaluate the changes induced by ospemifene on epithelium thickness, glycogen content proliferation index, collagen content, and type I/III collagen ratio in vulvar and vaginal tissue of post-menopausal women...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30446471/is-sexual-function-better-preserved-after-water-vapor-thermal-therapy-or-medical-therapy-for-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#4
Kevin T McVary, Tyson Rogers, Joseph Mahon, Nikhil K Gupta
BACKGROUND: Men often experience deterioration of sexual function after the use of α-blockers and 5-α reductase inhibitors for the treatment of lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia. Thus, an alternative treatment with water vapor thermal therapy (Rezūm System, Boston Scientific, Marlborough, MA, USA) which is an efficacious minimally invasive surgical treatment that preserves sexual function was examined. AIM: To compare sexual function over 3 years after continuous daily treatment with pharmaceutical agents in the Medical Therapy of Prostatic Symptoms (MTOPS) study vs a single thermal therapy procedure (Rezūm study) in subjects with matched criteria for LUTS severity and prostate size...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30446470/psychosexual-correlates-of-unwanted-sexual-experiences-in-women-consulting-for-female-sexual-dysfunction-according-to-their-timing-across-the-life-span
#5
Elisa Maseroli, Irene Scavello, Beatrice Campone, Vincenza Di Stasi, Sarah Cipriani, Federica Felciai, Viola Camartini, Angela Magini, Giovanni Castellini, Valdo Ricca, Mario Maggi, Linda Vignozzi
BACKGROUND: Comparative data on the psychopathologic and sexual correlates of unwanted sexual experiences (USEs) occurring during childhood, adolescence, or adult life are lacking. AIM: To investigate the prevalence of USEs in a setting of female sexual dysfunction (FSD) and to examine whether they are associated with different psychosexual parameters depending on the timing of occurrence. METHODS: A consecutive series of 200 heterosexual women attending our clinic for FSD was consecutively recruited...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30446469/outcome-of-medical-and-psychosexual-interventions-for-vaginismus-a-systematic-review-and-meta-analysis
#6
REVIEW
Elisa Maseroli, Irene Scavello, Giulia Rastrelli, Erika Limoncin, Sarah Cipriani, Giovanni Corona, Massimiliano Fambrini, Angela Magini, Emmanuele A Jannini, Mario Maggi, Linda Vignozzi
INTRODUCTION: Although vaginismus is a condition with a great impact on psychosexual well-being, the evidence on the efficacy of interventions is lacking. AIM: To review all information on vaginismus treatment, including data from randomized clinical trials (RCTs) and observational studies. METHODS: A systematic search was conducted of MEDLINE, EMBASE, PsycINFO, and ClinicalTrials.gov. 2 Independent meta-analyses of RCTs and observational studies were performed...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30446468/purulent-inflatable-penile-prostheses-can-be-safely-immediately-salvaged-in-insulin-dependent-diabetics
#7
Chloe E Peters, Evan C Carlos, Aaron C Lentz
INTRODUCTION: Historically, contra-indications for immediate salvage of an infected penile prosthesis have included purulence on the device, purulent infections in diabetic patients, and severe diabetes. These clinical principles are from the 1990s to early 2000s and based on limited retrospective series or expert opinion. Since the publication of these contra-indications there have been improvements in device design, surgical technique, corporal washout protocols, and perioperative antibiotic prophylaxis that allow us to re-evaluate whether we can broaden the criteria for immediate salvage of an infected penile prosthesis...
November 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30393105/association-between-multiple-sclerosis-and-risk-of-female-sexual-dysfunction-a-systematic-review-and-meta-analysis
#8
REVIEW
Shankun Zhao, Jiamin Wang, Yangzhou Liu, Lianmin Luo, Zhiguo Zhu, Ermao Li, Zhigang Zhao
INTRODUCTION: It has been reported that multiple sclerosis (MS) would increase the susceptibility to female sexual dysfunction (FSD). AIM: To assess whether MS was a risk factor for FSD through a comprehensive literature review and meta-analysis. METHODS: MEDLINE (PubMed), Embase, Cochrane Library, and PsychINFO databases were systematically searched for all studies reporting sexual function in women with MS. The protocol for this meta-analysis is available from PROSPERO (CRD42018094392)...
November 1, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30393104/summative-usability-evaluation-of-the-scte-ai-device-a-novel-prefilled-autoinjector-for-subcutaneous-testosterone-administration
#9
Samir Arora, Betsy Moclair, Kyle Murphy, Jonathan S Jaffe, Jed C Kaminetsky
BACKGROUND: The subcutaneous testosterone enanthate (TE) autoinjector (SCTE-AI) is a single-use, pre-filled, disposable autoinjector intended for testosterone (T) self-administration in adult males with T deficiency. AIM: To evaluate the usability of the market configuration of the SCTE-AI, including packaging and instructions for use (IFU), in order to identify and mitigate any preventable patterns of use errors that could result in harm. METHODS: 4 groups of participants (injection-naïve or injection-experienced patients or caregivers) were randomized to 1 of 3 doses (50, 75, and 100 mg) of TE and either trained (ie, reviewed the IFU and shown how to properly inject) or not trained (only given the IFU)...
November 1, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30341006/pharmacokinetics-safety-and-tolerability-of-single-oral-doses-of-a-novel-oxytocin-receptor-antagonist-cligosiban-in-development-for-premature-ejaculation-three-randomized-clinical-trials-in-healthy-subjects
#10
Ian H Osterloh, Gary J Muirhead, Stefan Sultana, Steven Whaley, Frans van den Berg, George Atiee
INTRODUCTION: Cligosiban is a selective oxytocin receptor antagonist being developed for the treatment of premature ejaculation (PE). AIM: Three clinical studies investigated the pharmacokinetics (including effect of food and formulation), central penetration, safety, and tolerability of single oral doses of cligosiban in healthy subjects. METHODS: Study 1 was a double-blind, randomized, placebo-controlled, crossover design in 3 cohorts of 10 subjects each...
October 16, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30327264/prevalence-of-female-sexual-function-difficulties-and-sexual-pain-assessed-by-the-female-sexual-function-index-a-systematic-review
#11
REVIEW
Thula U Koops, Peer Briken
INTRODUCTION: Sexual difficulties, and sexual pain in particular, represent a global health issue for women, and their prevalence has been shown to differ across countries. AIM: To review the existing literature on the prevalence of female sexual difficulties and sexual pain worldwide measured by the Female Sexual Function Index (FSFI). METHODS: We conducted a systematic literature review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
October 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30327263/self-reported-vaginal-laxity-prevalence-impact-and-associated-symptoms-in-women-attending-a-urogynecology-clinic
#12
Patrick Campbell, Michael Krychman, Thomas Gray, Holly Vickers, John Money-Taylor, Weiguang Li, Stephen Radley
INTRODUCTION: Vaginal laxity is increasingly recognized as an important condition, although little is known regarding its prevalence and associated symptoms. AIM: To report the prevalence of self-reported vaginal laxity in women attending a urogynecology clinic and investigate its association with pelvic floor symptoms and female sexual dysfunction. METHOD: Data were analyzed from 2,621 women who completed the electronic Personal Assessment Questionnaire-Pelvic Floor (ePAQ-PF)...
October 13, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30316737/comparison-of-the-effect-of-intermittent-and-continuous-aerobic-physical-training-on-sexual-function-of-women-with-polycystic-ovary-syndrome-randomized-controlled-trial
#13
Iris Palma Lopes, Victor Barbosa Ribeiro, Rosana Maria Reis, Rafael Costa Silva, Hugo Celso Dutra de Souza, Gislaine Satyko Kogure, Rui Alberto Ferriani, Lúcia Alves da Silva Lara
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common condition characterized by hyperandrogenism, anthropometric changes (increased weight and waist-to-hip ratio [WHR]), behavioral changes (sexual dysfunction, anxiety, and depression), and reduced quality of life. Physical exercise may reduce many of the adverse effects of PCOS. However, no studies have yet evaluated the effects of aerobic exercise on the sexual function of women with PCOS. AIM: To compare the effects of continuous and intermittent aerobic physical training on the sexual function and mood of women with PCOS...
October 10, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30297101/reduction-of-risk-factors-for-pedophilic-sexual-offending
#14
Jannis Engel, Mandy Körner, Petya Schuhmann, Tillmann H C Krüger, Uwe Hartmann
INTRODUCTION: Exploratory analysis of characteristics and reduction of risk factors for child sexual abuse (CSA) in a sample treated in the Prevention Projects Dunkelfeld Hannover and Regensburg. AIM: To evaluate a treatment program aimed at reducing dynamic risk factors (DRF) for CSA. METHODS: Using a psychometric test battery based on self-report questionnaires, intergroup analysis between treatment group (TG, n = 35), treatment refusers (TR, n = 51), and drop-out group (DO, n = 14) was conducted with pretreatment data...
October 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30274957/the-importance-of-male-ejaculation-for-female-sexual-satisfaction-and-function
#15
Andrea Burri, Joceline Buchmeier, Hartmut Porst
INTRODUCTION: Although links between ejaculatory control or intravaginal ejaculatory latency time and female sexual functioning have frequently been reported in the past, no study has investigated the importance of other male ejaculatory characteristics, such as ejaculation volume and intensity, for women's sexuality. AIM: To assess the importance of subjectively perceived ejaculation intensity and ejaculation volume for female sexual function and satisfaction. METHODS: This was a cross-sectional online survey including 240 sexually active, heterosexual women (median age 27...
September 28, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30245025/sildenafil-25-mg-odt-collagenase-clostridium-hystoliticum-vs-collagenase-clostridium-hystoliticum-alone-for-the-management-of-peyronie-s-disease-a-matched-pair-comparison-analysis
#16
Andrea Cocci, Gianmartin Cito, Daniele Urzì, Andrea Minervini, Fabrizio Di Maida, Francesco Sessa, Andrea Mari, Riccardo Campi, Marco Falcone, Marco Capece, Girolamo Morelli, Giovanni Cacciamani, Michele Rizzo, Chiara Polito, Bruno Giammusso, Giuseppe Morgia, Paolo Verze, Andrea Salonia, Tommaso Cai, Vincenzo Mirone, Nicola Mondaini, Giorgio Ivan Russo
INTRODUCTION: The effectiveness of phosphodiesterase type 5 (PDE5) inhibitors over the conservative management of Peyronie's disease (PD) has been widely questioned. AIM: To determine the role of sildenafil 25 mg film formulation twice a day (S25 b.i.d.) in the improvement of curvature after treatment of collagenase of Clostridium hystoliticum (CCH) in penile curvature owing to PD. METHODS: From April 2017 to April 2018, 161 consecutive patients were treated with S25 b...
September 20, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30245023/the-mediating-role-of-sexual-behavior-in-event-level-associations-between-sexual-difficulties-and-sexual-satisfaction-in-newlywed-mixed-sex-couples
#17
Jean-François Jodouin, Sophie Bergeron, Erick Janssen
INTRODUCTION: Many sexual difficulties encountered by couples in their day-to-day lives, although of insufficient intensity and persistence to warrant a clinical diagnosis of sexual disorder, are nevertheless frequent and a source of individual and relational distress. AIM: The aim of this study was to assess the event-level associations between couples' everyday, subclinical sexual difficulties (specifically, low subjective sexual arousal, low physiological sexual arousal, and genito-pelvic pain), the range of sexual behaviors that these couples engage in, and their sexual satisfaction...
September 20, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30228083/plication-for-severe-peyronie-s-deformities-has-similar-long-term-outcomes-to-milder-cases
#18
Rohit S Reddy, Maxim J McKibben, Joceline S Fuchs, Nabeel Shakir, Jeremy Scott, Allen F Morey
INTRODUCTION: Penile plication (PP) for Peyronie's disease (PD) is an established treatment option for mild to moderate curvature, but scant data exist regarding its utility in severe deformities. AIM: To evaluate long-term outcomes among men undergoing PP for PD, comparing severe to mild/moderate penile deformities. METHODS: We performed a retrospective review of patients who underwent PP for PD between 2009 and 2017. All patients underwent multiple parallel tunical plication without degloving...
September 15, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30195564/penile-sensory-changes-after-plaque-incision-and-grafting-surgery-for-peyronie-s-disease
#19
Jean E Terrier, Raanan Tal, Christian J Nelson, John P Mulhall
INTRODUCTION: Plaque incision and grafting (PIG) for Peyronie's disease (PD) is not devoid of complications such as erectile dysfunction and penile sensory changes. AIM: To define the rate and chronology of penile sensation loss after PIG surgery and to define predictors of such. METHODS: The study population consisted of patients with PD-associated penile curvature who underwent PIG surgery with at least 6 months of follow-up. Demographics and PD factors were recorded...
September 5, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/30195563/evidence-for-a-change-in-the-sex-ratio-of-children-referred-for-gender-dysphoria-data-from-the-gender-identity-development-service-in-london-2000-2017
#20
Nastasja M de Graaf, Polly Carmichael, Thomas D Steensma, Kenneth J Zucker
INTRODUCTION: The prevalence of gender dysphoria in children is not known; however, there are some data on the sex ratio of children referred to specialized gender identity clinics. AIM: We sought to examine the sex ratio of children, and some associated factors (age at referral and year of referral), referred to the Gender Identity Development Service in the United Kingdom, the largest such clinic in the world. METHODS: The sex ratio of children (N = 1,215) referred to the Gender Identity Development Service between 2000-2017 was examined, along with year of referral, age-related patterns, and age at referral...
September 5, 2018: Journal of Sexual Medicine
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