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Journal of Pediatric Hematology/oncology

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https://www.readbyqxmd.com/read/30102649/bronchoscopy-and-bronchoalveolar-lavage-in-the-diagnosis-and-management-of-pulmonary-infections-in-immunocompromised-children
#1
Suha Rizik, Fahed Hakim, Lea Bentur, Nira Arad-Cohen, Imad Kassis
BACKGROUND: Immunocompromised children are at high risk of rapid deterioration and of developing life-threatening pulmonary infections. Etiologies in this setting are diverse, including those that are infectious and noninfectious, and many etiologies may coexist. Accurate diagnosis is required for the rational use of medications. Fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) can identify infectious causes in this population. OBJECTIVES: The aims of this study were to evaluate diagnostic rate, safety, and changes in treatment following FOB with BAL, when applied with advanced laboratory diagnostic techniques...
August 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30102648/postchemotherapy-immunization-practices-for-non-hsct-pediatric-oncology-patients
#2
Lindy Zhang, Allison M Martin, Kathy Ruble
Pediatric oncology patients treated with antineoplastic therapy have impaired immune systems that lead to loss of protective antibodies. They require reimmunization to protect against vaccine-preventable diseases. There are a paucity of studies on the clinical practice of pediatric oncologists and the available recommendations are heterogenous. This study describes current reimmunization practices among pediatric oncologists. We surveyed the Children's Oncology Group (COG)-identified principle investigators to capture clinical practices among pediatric oncologists within their institutions regarding reimmunization of non-hematopoietic stem cell transplantation patients...
August 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30102647/national-survey-on-the-management-of-wilms-tumor
#3
Ahmed Elgendy, Sherif Shehata, Ahmed Medhat Zaki, Sameh Shehata
This study aims to investigate the management of Wilms tumor by the Egyptian pediatric surgical association (EPSA) consultants. After approval of the EPSA executive board, a questionnaire was distributed individually to all consultants attending the general assembly of EPSA 2017 annual congress. Of 88 consultants, responses were received from 61. Palpable abdominal mass was indicated by 72.13% of respondents as the commonest presenting symptom. Concerning the imaging requested, computed tomography was reported by 80...
August 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30102646/multiple-cavitary-lung-lesions-in-an-adolescent-case-report-of-a-rare-presentation-of-nodular-lymphocyte-predominant-hodgkin-lymphoma
#4
Moaaz Soliman, Fatima Neemuchwala, Amanda Sankar, Rama Jasty, Raja Rabah, Antonia P Popova, Erika A Newman
A 14-year-old male patient presented with a nonproductive cough, weight loss, fatigue, and malaise. A chest radiograph showed large bilateral cavitary lung lesions in both upper and lower lobes that failed to improve with antibiotics and anti-inflammatory medications. Infectious and rheumatologic work-ups were negative. Thoracoscopic lung biopsies were diagnostic for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The patient received combination chemotherapy and immunotherapy based on current treatment standards with an excellent clinical response...
August 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095695/population-based-cancer-registries-are-the-gold-standard-to-cancer-incidence
#5
Rejane S Reis, Beatriz de Camargo, Marceli O Santos
No abstract text is available yet for this article.
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095694/risk-markers-for-significant-bleeding-and-thrombosis-in-pediatric-acute-promyelocytic-leukemia-report-from-the-children-s-oncology-group-study-aaml0631
#6
Madhvi Rajpurkar, Todd A Alonzo, Yi-Cheng Wang, Robert B Gerbing, Alan S Gamis, James H Feusner, John Gregory, Matthew A Kutny
Acute promyelocytic leukemia (APL) is characterized by a heightened risk of coagulopathy with significant morbidity and mortality. Here we report our evaluation of presenting white blood cell (WBC) and the International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) scoring system as markers for early death and nonlethal coagulopathy in pediatric APL. We evaluated 79 pediatric patients treated on a Children's Oncology Group phase III clinical trial. There were 4 early deaths and 13 nonlethal, clinically significant (grade III to IV) coagulopathy events during induction...
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095693/childhood-head-and-neck-lymphadenopathy-a-report-by-a-single-institution-2003-2017
#7
Paolo Indolfi, Silverio Perrotta, Francesca Rossi, Martina Di Martino, Elvira Pota, Daniela Di Pinto, Giovanna Gualdiero, Emilia Boccieri, Cristiana Indolfi, Fiorina Casale
Actually, there is still no consensus related to diagnostic and management algorithms in case of head and neck lymphadenopathy in children. The aim of our study was to analyze the causes of head and neck lymphadenopathy in children to determine a systematic diagnostic approach. We enrolled all cases of head and neck lymphadenopathy in children under the age of 18 diagnosed at the Unit of Hemato-Oncology, Pediatric Department of University "Luigi Vanvitelli," Naples, over a 15-year period (January 2003-December 2017)...
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095692/successful-use-of-epoch-r-in-2-young-adult-patients-with-burkitt-lymphoma-and-acute-kidney-injury-a-case-report
#8
Savannah Ross, Kristen Eisenman, Kelly W Maloney
Pediatric Burkitt lymphoma has historically been treated with intensive methotrexate-based chemotherapy, which improves patient survival while causing severe toxicities. Young patients typically have better outcomes with intensive therapies, while adults and immunocompromised patients have higher toxicities and worse outcomes. Newer treatment regimens, including etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituximab (EPOCH-R), show promise for these patients. However, few studies exist to demonstrate efficacy and improved toxicity profile with EPOCH-R...
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095691/blood-stream-infections-and-antibiotic-utilization-in-pediatric-leukemia-patients-with-febrile-neutropenia
#9
James Reinecke, Stefanie Lowas, Jessica Snowden, Kari Neemann
BACKGROUND: Frequent surveillance of bacterial pathogens responsible for microbiologically defined-blood stream infections (MD-BSI), and their respective antibiotic susceptibilities is central to tailoring empiric antibiotic therapy in febrile neutropenia (FN) episodes in pediatric patients with leukemia. The safety of deescalating antibiotic therapy in pediatric patients with leukemia and neutropenia is incompletely understood. METHODS: A retrospective chart review of 194 FN episodes occurred between the years of 2013 and 2016 in 67 patients with leukemia...
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095690/cisplatin-induced-ototoxicity-in-children-with-solid-tumor
#10
Meng Wei, Xiaojun Yuan
Cisplatin is the principal chemotherapeutic agent and also tremendously increases the survival for pediatric patients with neuroblastoma or hepatoblastoma. With the extended overall survival period, clinical medical workers and parents gradually attach more attention to the late effect of chemotherapy of these children. The purpose of this study is to analyze the incidence and risk factors of cisplatin-based hearing loss. We retrospectively collected the archives of cisplatin-based chemotherapy and audiometric evaluation from 2005 through 2017 at Xinhua Hospital...
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30095689/a-case-of-allergic-broncopulmonary-aspergillosis-associated-with-hematopoietic-stem-cell-transplantation-due-to-chronic-granulomatous-disease
#11
Baris Malbora, Serap Aksoylar, Hamiyet H Ozdemir, Sinem Ozdemir, Savas Kansoy
Allergic bronchopulmonary aspergillosis is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus. This disorder is most commonly seen in patients with poorly controlled asthma and cystic fibrosis. It is rarely reported in chronic granulomatous disease patients; however, there are no cases reported with hematopoietic stem cell transplantation in the English literature. Herein, we report a patient with chronic granulomatous disease who had hematopoietic stem cell transplantation and subsequently developed allergic bronchopulmonary aspergillosis...
August 8, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30080755/is-mpv-a-predictive-marker-for-neonatal-sepsis-a-pilot-study
#12
Sridevi B Hanaganahalli, Saraswathy Sreeram, Mytreyi Bompada, Santosh K Kuppannagari, Pooja K Suresh, Cheryl S Philipose
Neonatal sepsis (NS) continues to be a diagnostic challenge and a prime cause of mortality. Forage for a lucid, cost-effective yet highly sensitive and specific marker in diagnosing this entity is an incessant task. This study aimed to evaluate the predictive value of mean platelet volume (MPV) in diagnosing NS. Neonates diagnosed with sepsis from January 2016 to March 2016 were included in the study. The subjects were stratified into the following: (i) culture-proven sepsis (group I); (ii) culture-negative clinical sepsis (group II); and (iii) control group (group III)...
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30080754/combination-oral-chelation-in-adult-patients-with-transfusion-dependent-thalassemia-and-high-iron-burden
#13
John Hammond, Alexis A Thompson, Mark A Fogel, Katherine Hammond, Jolene Kokroko, Janet L Kwiatkowski
An open-label, pilot study was conducted to evaluate deferasirox/deferiprone combination chelation therapy in adult patients with transfusion-dependent thalassemia and severe iron overload. Enrollment proved difficult. Nine patients (median age, 27.4 y; ferritin, 4965 ng/mL; liver iron concentration, 28.5 mg/g dry weight; cardiac T2*, 13.3 ms) received treatment. Two were withdrawn for treatment-related adverse effects. Arthralgia (4 patients) and gastrointestinal symptoms (5 patients) were common; no episodes of neutropenia/agranulocytosis occurred...
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30080753/risk-factors-and-the-prevention-of-weight-gain-during-induction-chemotherapy-in-children-with-acute-lymphoblastic-leukemia
#14
Fabiën N Belle, Rahel Kasteler
No abstract text is available yet for this article.
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30080752/eltrombopag-for-delayed-platelet-recovery-and-secondary-thrombocytopenia-following-allogeneic-stem-cell-transplantation-in-children
#15
Sidan Li, Runhui Wu, Bin Wang, Lingling Fu, Guanghua Zhu, Xuan Zhou, Jie Ma, Liqiang Zhang, Maoquan Qin
The delay in platelet recovery after hematopoietic stem cell transplantation (HSCT) is closely related to the overall survival rate of transplanted children. The use of platelet-producing agents such as eltrombopag and romiplostim has made great progress in treating diseases such as immune thrombocytopenia and aplastic anemia. However, the use of such drugs in patients with thrombocytopenia after transplantation, especially in children, is rare. This study aimed to report eltrombopag treatment for 3 children with primary platelet engraftment failure and secondary thrombocytopenia after allogeneic HSCT...
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30080751/weekly-rituximab-followed-by-monthly-rituximab-treatment-for-autoimmune-disease-associated-with-ras-associated-autoimmune-leukoproliferative-disease
#16
Hidemi Toyoda, Takao Deguchi, Shotaro Iwamoto, Kentaro Kihira, Hiroki Hori, Yoshihiro Komada, Masahiro Hirayama
Recently, a new disease of lymphocyte homeostasis caused by somatic mosaicism for the RAS mutation has been discovered (known as RALD, RAS-associated leukoproliferative disorder). Since few cases have been reported in literature, the prognosis and standard treatment for autoimmune diseases associated with RALD remain poorly understood. Standard rituximab therapy (375 mg/m for 4 wk) is effective in patients with autoimmune diseases, but early recurrences are common. We highlight the potential for monthly administration of rituximab in a patient with autoimmune thrombocytopenia and hemolytic anemia associated with RALD...
August 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30067557/c-kit-positive-fatal-diffuse-cutaneous-mastocytosis-with-systemic-manifestations-in-a-neonate
#17
Neha Chaudhary, Natasha Shapiro, Alok Bhutada, Shantanu Rastogi
Diffuse cutaneous mastocytosis is a rare variant of mastocytosis in the neonatal period. We describe a case of c-KIT (DV) mutation-positive fatal diffuse cutaneous mastocytosis with systemic involvement of the gastrointestinal tract and associated malabsorption and hepatosplenomegaly associated with mast cell mediator release symptoms.
July 31, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30067556/first-intracardiac-kaposiform-hemangioendothelioma-in-an-infant-resolved-with-sirolimus-a-case-report
#18
Syed Javed Zaidi, Shaista Shaik, Caitlin Agrawal, Waseem Cossor
INTRODUCTION: Kaposiform hemangioendothelioma (KHE) is a rare and aggressive vascular tumor that can be associated with a consumptive coagulopathy and thrombocytopenia (Kasabach-Merritt phenomenon). Only one case of an intracardiac KHE has been reported which was treated with surgical excision and then expectant management. CASE PRESENTATION: We present a patient with an intracardiac KHE which presented as a large mass surrounding the atria, pulmonary veins, superior vena cava, and infiltrating the atrial septum with moderate compression of the superior vena cava and mild compression of the pulmonary veins...
July 31, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30059355/fab-lmb-96-regimen-for-newly-diagnosed-burkitt-lymphoma-in-children-single-center-experience
#19
Burca Aydin, Canan Akyuz, Neslihan Kalkan, Nilgun Kurucu, Ali Varan, Bilgehan Yalcin, Tezer Kutluk
BACKGROUND/OBJECTIVES: The outcome of Burkitt lymphoma has improved by over 90%. In this study, demographic characteristics and outcomes of 57 patients with Burkitt lymphoma treated with FAB LMB 96 regimen are presented. MATERIALS AND METHODS: Standard intensity arms were selected for all risk groups. Clinical characteristics, response to treatment, and outcome were evaluated. RESULTS: The median age of 48 boys and 9 girls was 8.2 years. There were 2 (3%), 41 (72%), and 14 (25%) patients in the low, intermediate, and high-risk groups, respectively...
July 27, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/30028825/special-therapy-and-psychosocial-needs-identified-in-a-multidisciplinary-cancer-predisposition-syndrome-clinic
#20
Andrew P Groves, Katie Gettinger, Todd E Druley, Beth A Kozel, Marwan Shinawi, Caroline Mohrmann, Jennifer Henry, Celina Jacobi, Kathryn Trinkaus, Robert J Hayashi
Identification of patients with cancer predisposition syndromes (CPSs) can provide vital information to guide care of an existing cancer, survey for future malignancy, and counsel families. The same underlying mutation responsible for a CPS may also result in other phenotypic abnormalities amenable to therapeutic intervention. The purpose of this study was to examine patients followed in our multidisciplinary CPS clinic to determine the prevalence and scope of medical and psychosocial needs. Data from a baseline evaluation of a single-center patient registry was reviewed...
July 26, 2018: Journal of Pediatric Hematology/oncology
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