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Journal of Pediatric Gastroenterology and Nutrition

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https://www.readbyqxmd.com/read/30633110/predictors-of-long-term-clinical-and-endoscopic-remission-in-children-with-crohn-s-disease-treated-with-infliximab
#1
Giulia D'Arcangelo, Salvatore Oliva, Anna Dilillo, Franca Viola, Fortunata Civitelli, Sara Isoldi, Salvatore Cucchiara, Marina Aloi
OBJECTIVES: We aimed to identify early non-invasive predictors of clinical and endoscopic remission in children with Crohn's disease (CD) under infliximab (IFX). METHODS: Prospective observational study conducted in children with moderate-to-severe CD starting IFX. All patients underwent weighted pediatric CD activity index (wPCDAI) assessment, C-reactive protein (CRP) and fecal calprotectin (FC) at week 0, 14 and 48. Endoscopy was performed at 0 and 48 weeks. The primary outcome was to determine the ability of 14-week wPCDAI, CRP and FC to predict 1- year steroid-free clinical remission and mucosal healing...
January 8, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30633109/preterm-birth-has-effects-on-gut-colonization-in-piglets-within-the-first-4-weeks-of-life
#2
Shamrulazhar Shamzir Kamal, Anders Daniel Andersen, Lukasz Krych, Charlotte Lauridsen, Per Torp Sangild, Thomas Thymann, Dennis Sandris Nielsen
OBJECTIVES: Preterm neonates have an immature gastrointestinal tract and show an altered bacterial colonization of the gut. However, it is not clear if such immature gut microbiota (GM) colonization is induced by specific delivery, diet, environment and/or host factors related to preterm birth. Using piglets as models for infants, we hypothesized that both shortened gestational age (GA) and start of enteral feeding affect GM composition after caesarean delivery and rearing in identical environments...
January 8, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30633108/adequate-infliximab-exposure-during-induction-predicts-remission-in-paediatric-patients-with-inflammatory-bowel-disease
#3
Karen van Hoeve, Erwin Dreesen, Ilse Hoffman, Gert Van Assche, Marc Ferrante, Ann Gils, Séverine Vermeire
OBJECTIVES: Therapeutic drug monitoring has been proposed as a useful tool in the management of infliximab (IFX) treated patients with inflammatory bowel disease (IBD). The aim of this retrospective study was to determine whether IFX trough levels after induction therapy are predictive for outcome at week 52. METHODS: All paediatric IBD patients receiving maintenance IFX at our centre, with IFX trough level available at their first maintenance infusion and a follow-up of at least 52 weeks were included...
January 8, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30633107/long-term-outcomes-of-an-interdisciplinary-tube-weaning-program-a-quantitative-study
#4
Sabine Marinschek, Karoline Pahsini, Peter Jaron Scheer, Marguerite Dunitz-Scheer
BACKGROUND AND OBJECTIVES: Children who become tube dependent need specialized treatment in order to make the transition to oral feeding. Little is known about long-term effects of tube weaning programs. This study analyses long-term effects (outcome, growth and nutrition data) in a large sample of formerly tube dependent children 1-6 years after participation in tube weaning programs, based on the "Graz model of tube weaning". METHODS: Parents of children who completed a tube weaning program between 2009 and 2014 (N = 564) were asked to complete a questionnaire on their child's growth and nutrition...
January 8, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30633106/application-of-whole-exome-sequencing-in-congenital-secretory-diarrhea-diagnosis
#5
Ashish Gupta, Julie Sanville, Timothy Menz, Neil Warner, Aleixo M Muise, Karoline Fiedler, Martín G Martín, James Padbury, Chanika Phornphutkul, Juan Sanchez-Esteban, Carolina S Cerezo
No abstract text is available yet for this article.
January 8, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30633105/transient-exocrine-pancreatic-insufficiency-in-children-an-existing-entity
#6
Jamal Garah, Irit Rosen, Ron Shaoul
OBJECTIVES: Pancreatic insufficiency in children is usually associated with diseases such as cystic fibrosis, Shwachman-Diamond syndrome, or chronic pancreatitis. Fecal elastase-1 is a reliable laboratory test for the diagnosis of exocrine pancreatic insufficiency (EPI). Transient pancreatic insufficiency has been rarely described and data on this entity are lacking in the medical literature. In this retrospective study we report 17 cases of transient pancreatic insufficiency presented mainly with failure to thrive and/or diarrhea...
January 8, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628989/hepatic-lesions-associated-with-mccune-albright-syndrome
#7
Lauren Johansen, Wolfram Haller, Manigandan Thyagarajan, Deirdre Kelly, Patrick McKiernan
McCune Albright Syndrome (MAS) results from a GNAS gene mutation. It is associated with café-au-lait macules, fibrous dysplasia, and several endocrinopathies to include gonadotropin-independent precocious puberty, growth hormone excess, Cushing syndrome, thyroid disease, and renal phosphate wasting. It is recognised to be a rare cause of neonatal cholestasis.We describe the hepatic outcome of three children with MAS referred to a single national liver unit. All presented with high gamma-glutamyl transpeptidase cholestasis and hepatitis...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628988/congenital-portosystemic-shunts-current-diagnosis-and-management
#8
Valérie A McLin, Stephanie Franchi-Abella, Dominique Debray, Florent Guérin, Maurice Beghetti, Laurent Savale, Barbara E Wildhaber, Emmanuel Gonzales
Congenital porto-systemic shunts are increasingly recognized in several settings and at any age. The following are some of the most common presentations: prenatal ultrasound, neonatal cholestasis, incidental finding on abdominal imaging, or systemic complications such as unexplained cardiopulmonary or neurological disease, or the presence of liver nodules in a non-cirrhotic liver. The purpose of the present review is to summarize clinical presentation and current recommendations for management, and highlight areas of future research...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628987/change-in-prevalence-of-family-history-during-long-term-follow-up-of-pediatric-onset-inflammatory-bowel-disease-patients
#9
Kristin Capone, Harry J Rosenberg, Kristen Wroblewski, Ranjana Gokhale, Barbara S Kirschner
OBJECTIVES: To prospectively study changes in prevalence of positive family history (FH+) in pediatric-onset inflammatory bowel disease (IBD) in contrast to previously published cross-sectional data. METHODS: An observational cohort study was performed using a prospective pediatric-onset IBD database including 485 patients with disease duration ≥10yrs as of December 2016. Proband characteristics and FH+ were obtained at diagnosis and subsequently from the database, medical records and follow-up telephone interviews in 2006 and 2016...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628986/endoscopic-management-of-duodenal-web
#10
Robin Luffy, David M Troendle
No abstract text is available yet for this article.
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628985/correlation-between-clinical-signs-and-high-resolution-manometry-data-in-children
#11
Marine Juzaud, Marie-Dominique Lamblin, Alexandre Fabre, Marine Alessandrini, Karine Baumstarck, Camille Bazin, Clothilde Esteve, Nolwenn Laborde, Lindsay Osei, Laurent Michaud, Frederic Gottrand, Veronique Vitton
OBJECTIVES: High-resolution manometry (HRM) is the gold standard for diagnosis of esophageal motility disorders. However, clinical signs associated with these disorders are non-specific, and it is difficult to correlate clinical signs with HRM data. The main objective of our study was to assess the positive predictive value (PPV) and negative predictive value (NPV) of each clinical sign, as well as their sensitivity and specificity in the diagnosis of esophageal motility disorders. METHODS: This is a bicentric retrospective cohort study based on HRM data collected between May 2012 and May 2016...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628984/barium-enema-revisited-in-the-workup-for-the-diagnosis-of-hirschsprung-s-disease
#12
Pedro Luiz Toledo de Arruda Lourenção, Felipe Gilberto Valerini, Antonio Jose Maria Cataneo, Erika Veruska Paiva Ortolan, Guilherme Lopes da Silveira, Mariana Floriano Luiza Piva, Lucas da Matta Cucco, Maria Aparecida Marchesan Rodrigues
The diagnostic capacity of barium enema (BE) in the diagnostic investigation for Hirschsprung's disease (HD) was analyzed for transition zone (TZ) identification and rectosigmoid index (RSI) ≤ 1.0 determination. BE images were analyzed retrospectively by two examiners and the results were compared with the histopathology of rectal biopsies. TZ identification and RSI ≤ 1.0 were assessed separately and combined in 43 patients. Twelve (27.9%) patients had the diagnosis of HD based on rectal biopsies. TZ identification presented better diagnostic capacity for the two examiners than RSI ≤ 1...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628983/vitamin-d-and-inflammatory-mediators-in-preterm-infants-with-late-onset-sepsis-a-randomized-controlled-trial
#13
Hesham Abdel-Hady, Sohier Yahia, Ahmed Megahed, Abeer Mosbah, Basma Seif, Eman Nageh, Indrani Bhattacharjee, Hany Aly
OBJECTIVE: To evaluate biochemical and clinical effects of two different doses of vitamin D supplementation in preterm infants with late onset sepsis (LOS). STUDY DESIGN: A double blinded randomized controlled stratified trial included preterm infants with gestational age (GA) ≥28 weeks with LOS. Subjects were randomly assigned to receive 400 or 800 IU/d of vitamin D3. Serum concentrations of 25(OH)D, TNF-α and IL-6 were measured at enrollment, 7 days after vitamin D supplementation, and at 40 weeks of postmenstrual age (PMA)...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628982/biliary-atresia-associated-cholangitis-the-central-role-and-effective-management-of-bile-lakes
#14
Daniel Andreas Ginström, Maria Hukkinen, Reetta Kivisaari, Mikko P Pakarinen
OBJECTIVES: Cholangitis and bile lakes are incompletely understood complications after portoenterostomy (PE). We investigated relationships between recurrent cholangitis, bile lakes and clinical outcomes as well as surgical management of bile lakes. METHODS: In this retrospective observational single institution study medical records and imaging studies of all patients who had undergone PE for biliary atresia during 1987-2016 (N = 61) were reviewed. We related occurrence of cholangitis episodes with the presence of intrahepatic bile lakes, patient characteristics, and PE outcomes...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30628981/serum-calprotectin-in-adolescents-with-inflammatory-bowel-disease-a-pilot-investigation
#15
Katrine Carlsen, Mikkel Malham, Lars Folmer Hansen, Jens Jakob Herrche Petersen, Anders Paerregaard, Gunnar Houen, Vibeke Wewer
OBJECTIVES: Fecal calprotectin (FC) is a well-integrated parameter in the monitoring of adolescent patients with inflammatory bowel disease (IBD). However, measurement of FC is limited by day-to-day-variation and by the feces' consistency. Furthermore, adolescents are often non-compliant to deliver fecal sampling leading to suboptimal monitoring. Consequently, we see the need of a substitute biomarker when measurement of FC fails and aimed to investigate serum calprotectin (SC) in adolescents with IBD...
January 4, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30614952/prevalence-of-eosinophilic-esophagitis-in-adolescents-with-esophageal-atresia
#16
Emilie Lardenois, Laurent Michaud, Anne Schneider, Mihaela Onea, Julie Rebeuh, Madeleine Gottrand-Aumar, Florence Renaud, Frederic Gottrand, Emmanuelle Leteurtre
BACKGROUND AND OBJECTIVE: Eosinophilic esophagitis (EoE) is an increasingly recognized childhood disease. Esophageal atresia (EA) is the most frequent congenital malformation of the esophagus. Recently, cases of EoE occurring in patients with EA have been reported, although the exact prevalence of EoE in EA remains unknown. The aim is to investigate the prevalence of EoE among EA in adolescents and to describe these patients' characteristics. METHODS: Systematic upper gastrointestinal endoscopies with multistage esophageal biopsies were prospectively performed in 63 adolescents with EA...
January 2, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30614951/autologous-intestinal-reconstructive-surgery-in-the-management-of-total-intestinal-aganglionosis
#17
Fabio Fusaro, Francesco Morini, Annika Mutanen, Paola De Angelis, Roberto Tambucci, Teresa Capriati, Dominique Hermans, Manila Candusso, Antonella Diamanti, Pietro Bagolan, Mikko Pakarinen
OBJECTIVES: Total/Near Total intestinal aganglionosis (TIA/NTIA) is the most uncommon and life-threatening form of Hirschsprung disease (HD). The management of TIA/NTIA is challenging and the role of autologous intestinal reconstructive (AIR) surgery is controversial. The objective is to evaluate the effectiveness of AIR in patients with TIA/NTIA. METHODS: Records from children affected by total intestinal aganglionosis and enrolled in the multicenter international Pediatric Intestinal Rehabilitation and Transplantation Registry (PIRAT) were retrospectively reviewed...
January 2, 2019: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30614955/2018-harry-shwachman-award
#18
Carlo Di Lorenzo
No abstract text is available yet for this article.
December 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30614954/pyoderma-gangrenosum-of-the-finger-associated-with-pediatric-ulcerative-colitis
#19
Minoru Shinagawa, Takashi Ishige, Yoshiko Igarashi, Takumi Takizawa, Hirokazu Arakawa
No abstract text is available yet for this article.
December 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30614953/endoscopic-pancreatic-function-test-epft-and-its-indications
#20
Karoly Horvath, Devendra I Mehta, Ivor D Hill
This paper will review briefly the physiology of pancreatic enzyme secretion and the role of stimulated endoscopic testing for assessing exocrine pancreatic function. Published studies in both the pediatric and adult literature are reviewed. The technique and utility of endoscopic pancreatic function testing (ePFT) as the method of choice in the differential diagnosis of pancreatic disorders in childhood is described. Finally, emerging, clinically useful markers that can be measured in the pancreatic fluid will be described...
December 29, 2018: Journal of Pediatric Gastroenterology and Nutrition
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