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Journal of Pediatric Gastroenterology and Nutrition

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https://www.readbyqxmd.com/read/30212423/bladder-symptoms-in-children-with-functional-constipation-a-systematic-review
#1
Jojanneke J G T van Summeren, Gea A Holtman, Sonja C van Ommeren, Boudewijn J Kollen, Janny H Dekker, Marjolein Y Berger
OBJECTIVE: To perform a systematic review of the literature examining the prevalence of bladder symptoms in children with functional constipation (FC), and to compare the prevalence of those symptoms between children with and without FC. METHODS: In this systematic review 4 databases were searched to July 2018. Studies investigating the prevalence of bladder symptoms in children aged 4 to 17 years with FC were included. There was no language restriction. Two reviewers independently extracted data and assessed study quality...
September 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211847/direct-acting-antiviral-therapy-is-safe-and-effective-in-pediatric-chronic-hepatitis-c-the-public-health-perspective
#2
Radha K Dhiman, Gagandeep S Grover, Madhumita Premkumar, Sunil Taneja, Ajay Duseja, Sahaj Rathi, Sandeep Satsangi
OBJECTIVES: We assessed the efficacy of decentralised public health services and safety of direct-acting antiviral agents (DAAs) in the treatment of pediatric CHC in the Mukh-Mantri Punjab Hepatitis C Relief Fund, a public-health initiative for prevention and control of chronic hepatitis C(CHC) in Punjab, India. METHODS: Consecutive children with CHC [age ≥12 to <18 years; both treatment-naïve (TN) and treatment-experienced (TE)] were enrolled. Genotyping was not recommended for non-cirrhotic patients and were treated with sofosbuvir (SOF)+ daclatasvir (DCV) for 12-weeks, while genotyping was recommended for patients with cirrhosis...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211846/development-and-pilot-implementation-of-a-nutrition-curriculum-and-rotation-in-pediatric-gastroenterology-fellowships
#3
Ala Shaikhkhalil, Candi Jump, Praveen S Goday
Structured nutrition rotations are rarely offered in pediatric gastroenterology fellowships. The NASPGHAN Nutrition Committee developed a curriculum to serve as the basis for a rotation in clinical nutrition. We worked directly with five fellowship programs to tailor the experience to individual institutions. As part of our pilot study, fellows completed knowledge assessments and self-assessment of comfort level at the start and end of the experience. We saw a trend in improvement of comfort level and increase in mean score on knowledge assessments, but the differences did not meet statistical significance...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211845/causes-of-treatment-failure-in-children-with-inflammatory-bowel-disease-treated-with-infliximab-a-pharmacokinetic-study
#4
Samuele Naviglio, Doriana Lacorte, Marianna Lucafò, Adriana Cifù, Diego Favretto, Eva Cuzzoni, Tania Silvestri, Martina Pozzi Mucelli, Oriano Radillo, Giuliana Decorti, Martina Fabris, Matteo Bramuzzo, Andrea Taddio, Gabriele Stocco, Patrizia Alvisi, Alessandro Ventura, Stefano Martelossi
OBJECTIVES: Anti-tumor necrosis factor antibodies have led to a revolution in the treatment of inflammatory bowel diseases (IBD), however a sizable proportion of patients do not respond to therapy. There is increasing evidence suggesting that treatment failure may be classified as mechanistic, pharmacokinetic, or immune-mediated. Data regarding the contribution of these factors in children with IBD treated with infliximab (IFX) are still incomplete. The aim was to assess the causes of treatment failure in a prospective cohort of pediatric patients treated with IFX...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211844/there-is-no-excuse-for-mortality-due-to-lack-of-competency-and-training-of-paediatric-endoscopists-in-gastrointestinal-bleeding-therapy-in-2018
#5
Mike Thomson
Acute upper gastrointestinal bleeding in children is possibly the last medical emergency which continues to lead to the death of a child due to the lack of competency/clinical judgement of the doctor, as opposed to the disease itself, leading to mortality despite optimum medical intervention. This is unacceptable in any circumstances in 2018. It occurs due to a number of conspiring factors including lack of appreciation of the clinical presentation requiring urgent endoscopic intervention; misapprehension of the urgency of timing required of such an intervention predicated on the severity of the gastrointestinal (GI) bleed; lack of application of a paediatric-specific validated score predicting for such endoscopic intervention; lack of skill in endo-haemostatic intervention techniques by paediatric endoscopists; poor training in such techniques among paediatric endoscopists; paucity of cases with lack of exposure of the paediatric endoscopist regularly to enable skills to be maintained, once acquired; reluctance of adult endoscopists in many centres to support paediatric GI bleeding services...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211843/classification-and-nutrition-management-of-acute-pancreatitis-in-the-pediatric-intensive-care-unit
#6
Sarah Cole, Martin Wakeham, Steven Werlin, Praveen S Goday
The aims of this retrospective cohort study were to classify the severity of patients admitted to the PICU with acute pancreatitis (AP) and to identify how many patients received appropriate nutritional management in accordance with more recent guidelines and the outcomes of those patients. Of the 54 children with AP, 12 (22.2%) had a primary diagnosis of AP (50% severe, 17% moderate) while 42 (77.8%) had a secondary diagnosis of AP (81% severe, 11.9% moderate). Just under half of the patients (48.1%) had enteral nutrition commenced before the third day of admission (50% with primary AP, 47...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211842/il-9-alters-epithelial-barrier-and-e-cadherin-in-eosinophilic-esophagitis
#7
Ashmi Doshi, Rebecca Khamishon, Renee Rawson, Loan Duong, Lucas Dohil, Stephen J Myers, Braxton Bell, Ranjan Dohil, Robert O Newbury, Kim E Barrett, Richard C Kurten, Seema S Aceves
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic Th2-assocated inflammatory condition accompanied by substantial impairments in epithelial barrier function and increased numbers of IL-9 expressing inflammatory cells. While IL-9 is known to affect barrier function in the intestine, the functional effects of IL-9 on the esophagus are unclear. Herein we aimed to understand the expression of the IL-9 receptor and effects of IL-9 on the epithelium in EoE. METHODS: We used esophageal biopsies from pediatric EoE patients with active and inactive disease to analyze the expression of the IL-9 receptor, the adherens junction protein E-cadherin and the tight junction protein claudin-1...
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30211841/early-life-factors-and-eosinophilic-esophagitis-building-the-evidence
#8
Elizabeth T Jensen, Sandeep K Gupta
No abstract text is available yet for this article.
September 11, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30169455/enteric-virome-and-bacterial-microbiota-in-children-with-ulcerative-colitis-and-crohn-s-disease
#9
Melissa A Fernandes, Sofia G Verstraete, Tung G Phan, Xutao Deng, Emily Stekol, Brandon LaMere, Susan V Lynch, Melvin B Heyman, Eric Delwart
OBJECTIVES: We examined the fecal enteric virome and bacterial community composition of children with Crohn's disease (CD), ulcerative colitis (UC), and healthy controls to test the hypothesis that unique patterns of viral organisms and/or presence of bacterial pathogens may be identified that could contribute to the pathogenesis of pediatric inflammatory bowel disease (IBD). METHODS: Fecal samples from 24 children (mean 12.2 years) with CD (n = 7) or UC (n = 5) and similar aged controls (n = 12) were processed to determine individual viromes...
August 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30169454/use-of-biosimilars-in-paediatric-inflammatory-bowel-disease-an-updated-position-statement-of-the-paediatric-ibd-porto-group-of-espghan
#10
Lissy de Ridder, Amit Assa, Jiri Bronsky, Claudio Romano, Richard K Russell, Nadeem A Afzal, Almuthe Christina Hauer, Daniela Knafelz, Paolo Lionetti, Caterina Strisciuglio, Gábor Veres, Harland Winter, Victorien M Wolters, Malgorzata Sladek, Arnold G Vulto, Jorge Amil Dias
Biologic therapies have changed the outcome of both adult and paediatric patients with Inflammatory Bowel Disease (IBD). In September 2013, the first biosimilar of infliximab was introduced into the pharmaceutical market. In 2015, a first position paper on the use of biosimilars in paediatric IBD was published by the ESPGHAN IBD Porto group. Since then, more data have accumulated for both adults and children demonstrating biosimilars are an effective and safe alternative to the originator. In this updated position statement we summarize current evidence and provide joint consensus statements regarding the recommended practice of biosimilar use in children with IBD...
August 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30169453/anxiety-and-salivary-cortisol-levels-in-children-undergoing-esophago-gastro-duodenoscopy-under-sedation
#11
Duygu Kara, Nevzat Aykut Bayrak, Burcu Volkan, Cihat Uçar, Mehmet Nuri Cevizci, Sedat Yılmaz
OBJECTIVES: Esophagogastroduodenoscopy (EGD) can cause fear and anxiety in children. Cortisol, which is the most important glucocorticoid hormone in humans, can increase under physiological stress. The purpose of this study was to measure the salivary cortisol level (SCL) and anxiety level in patients undergoing EGD and evaluate their effects on the procedure. METHODS: Children undergoing EGD under sedoanalgesia with propofol for various reasons were included. Their basal SCLs were compared with those of healthy age- and sex-matched controls...
August 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30134332/clarifying-the-definition-of-breast-milk-substitutes
#12
Laurence M Grummer-Strawn
No abstract text is available yet for this article.
August 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30134331/lack-of-benefit-of-lactobacillus-reuteri-dsm-17938-as-an-addition-to-the-treatment-of-functional-constipation
#13
Oleg Jadrešin, Sara Sila, Ivana Trivić, Zrinjka Mišak, Iva Hojsak, Sanja Kolaček
The aim of this study was to investigate the role of Lactobacillus (L.) reuteri DSM 17983 in the treatment of functional constipation in children. The trial was a single-center randomized, double-blind, placebo-controlled study. Patients were allocated into the two groups; intervention group which received L. reuteri DSM 17983 and lactulose and placebo group which received placebo and lactulose.Due to small recruitment rate study was terminated prematurely, therefore only 33 children (12 girls, median age 4...
August 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30134330/multi-organ-transplantation-as-a-viable-treatment-option-in-infantile-juvenile-polyposis-syndrome
#14
Ojasvini Choudhry Chandan, Emille Reyes-Santiago, Luciano Vargas, David Mercer, Wendy Grant, Alan Langnas, Ruben E Quiros-Tejeira, Hanh Vo
No abstract text is available yet for this article.
August 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30119101/weight-gain-trajectory-predicts-long-term-overweight-and-obesity-after-pediatric-liver-transplant
#15
Sonja Marie Swenson, Emily R Perito
OBJECTIVE: To identify early predictors of long-term overweight and obesity in pediatric liver transplant recipients. METHODS: Single-center, retrospective review of children who underwent liver transplant before age 6 years. Body Mass Index (BMI), weight, and height percentiles at transplant and post-transplant were calculated. BMI, weight gain trajectories, and failure-to-thrive (FTT) were examined as predictors of overweight/obesity at 3 and 5 years post-transplant...
August 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30119100/use-of-breast-milk-and-other-feeding-practices-following-gastrointestinal-surgery-in-infants
#16
Sanskriti Varma, Edward L Bartlett, Lucy Nam, Darla R Shores
OBJECTIVES: To characterize the enteral feeding practices in infants following gastrointestinal surgery. METHODS: We performed a retrospective analysis of infants who underwent intestinal surgery at age <6 months who survived to be fed enterally between January 2012-June 2017. Demographics, surgical characteristics, feeding practices, and growth-related outcomes during hospitalization, discharge, and follow-up (three-, six-, and twelve-months) were obtained from the electronic medical records...
August 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30119099/espghan-distinguished-service-award-2018-to-professor-markku-m%C3%A3-ki
#17
Raanan Shamir, Alina Popp
No abstract text is available yet for this article.
August 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30119098/contribution-of-oral-hygiene-and-cosmetics-on-contamination-of-gluten-free-diet-do-celiac-customers-need-to-worry-about
#18
Anil K Verma, Elena Lionetti, Simona Gatti, Elisa Franceschini, Giulia Naspi Catassi, Carlo Catassi
OBJECTIVES: The only available treatment for celiac disease (CD) is the gluten-free diet. It is unclear whether the presence of gluten in oral hygiene products and cosmetics that are applied on the mouth is a reason of concern for CD patients. The aim of this study was to test the level of gluten contamination in oral hygiene and cosmetic products available in the Italian market. METHODS: A total of 66 products (toothpastes = 37; dental tablets = 2; mouthwashes = 5; lip-balms = 10; lipsticks = 12) labelled gluten-free or with unknown gluten content were randomly collected from different supermarkets and pharmacies...
August 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30095579/acute-kidney-injury-may-not-be-as-uncommon-as-believed-in-children-with-advanced-chronic-liver-diseases
#19
Bikrant Bihari Lal, Priti Vijay, Vikrant Sood, Rajeev Khanna, Seema Alam
No abstract text is available yet for this article.
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30095578/incidence-and-clinical-features-of-autoimmune-hepatitis-in-the-province-of-santa-fe-argentina
#20
Alejandro Carlos Costaguta, Andrea González, Sandra Pochettino, Liliana Trotta, Rosalía Vicentín, Marta Wagener
OBJETIVES: To investigate the incidence and clinical features of autoimmune hepatitis (AIH) in children from the province of Santa Fe, Argentina, over ten years. METHODS: From the records of all of the pediatric hepatologists in the province of Santa Fe, Argentina, we reviewed the clinical charts of patients < 18 years who were diagnosed with AIH (simplified score >6 points) and followed between January 2003 and December 2013. Population data were extracted from the 2010 national census...
August 8, 2018: Journal of Pediatric Gastroenterology and Nutrition
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