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Journal of Pediatric Gastroenterology and Nutrition

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https://www.readbyqxmd.com/read/28820758/lack-of-association-between-interleukin-28b-polymorphism-and-vertical-transmission-of-hepatitis-c
#1
Afrodite Psaros Einberg, Ann-Sofi Duberg, Olga Filipovich, Jessica Nyström, Anton Zhirkov, Erwin Daniel Brenndörfer, Lars Frelin, Elena Rukoiatkina, Yuriy Lobzin, Matti Sällberg, Björn Fischler, Anton Lutckii
OBJECTIVES: Single genetic nucleotide polymorphism (rs12979860) near the gene for Interleukin 28B (IL28B), is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon based therapies in patients with hepatitis C virus (HCV) infection. The aim of this study was to investigate if IL28B polymorphism in children and/or their mothers plays a role in vertical transmission of HCV (HCV-VT). METHODS: Plasma samples from 59 infected women, 76 uninfected children born to infected mothers, and 47 children with known vertically transmitted HCV infection, were analysed for IL28B polymorphism and classified by the IL28B genotype (C/C, C/T and T/T) as well as by viral genotype...
August 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28806298/effect-of-cyproheptadine-on-weight-and-growth-velocity-in-children-with-silver-russell-syndrome
#2
Anaïs Lemoine, Madeleine D Harbison, Jennifer Salem, Patrick Tounian, Irène Netchine, Béatrice Dubern
OBJECTIVES: Nutritional management of children with Silver-Russell syndrome (SRS) is crucial, especially before initiating growth hormone therapy (GHT). Since cyproheptadine (CYP) has been reported to be orexigenic, we retrospectively investigated the effects of CYP on changes in weight and height in SRS patients. METHODS: Anthropometric parameters (weight [W], length or height [H], relative body weight for height [W/H] and body mass index [BMI]) were recorded for 34 children with SRS receiving CYP...
August 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28806297/adherence-to-a-gluten-free-diet-assessment-by-dietician-interview-and-serology
#3
Pooja Mehta, Zhaoxing Pan, Marisa Dzarnoski Riley, Edwin Liu
We aimed to 1) determine if tissue transglutaminase autoantibody (tTG) positivity was associated with dietitian-assessed adherence to a gluten-free diet in pediatric patients with celiac disease and 2) identify areas where adherence falters. We reviewed the records of children with celiac disease who had a standardized evaluation of adherence by a registered dietitian. A negative tTG value was not associated with good adherence (p = NS). Adherent and nonadherent children differed with respect to purposeful and accidental gluten exposure (p < 0...
August 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28806296/the-risk-of-necrotizing-enterocolitis-differs-among-preterm-pigs-fed-formulas-with-either-lactose-or-maltodextrin
#4
Randal K Buddington, Samantha L Davis, Karyl K Buddington
OBJECTIVES: When breast milk is unavailable for preterm infants, formulas are needed that won't increase the risk of necrotizing enterocolitis (NEC). Adding novel ingredients to formula to reduce NEC has not been effective clinically. Instead, we tested the prediction that NEC can be reduced by removing the maltodextrin now included in preterm formulas. METHODS: The preterm pig model of spontaneous NEC was used to evaluate growth, health, and intestinal responses to 6-7 days of feeding formulas that were identical except for the source of carbohydrate; either 100% lactose or maltodextrin; colostrum was used as the control...
August 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28806295/splenules-presenting-as-incidental-gastric-fundic-masses-on-endoscopy
#5
Ammar Khayat, Alfonso M Martinez
No abstract text is available yet for this article.
August 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28800026/espghan-distinguished-service-award-2017-to-professor-olivier-goulet
#6
Raanan Shamir
No abstract text is available yet for this article.
August 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28800025/response-to-letter-to-the-editor-bile-acid-replacement-in-bile-acid-synthesis-defects
#7
Alan F Hofmann
No abstract text is available yet for this article.
August 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28777126/the-role-of-polyethylene-glycol-in-the-treatment-of-functional-constipation-in-children
#8
Ilan J N Koppen, Ilse J Broekaert, Michael Wilschanski, Alexandra Papadopoulou, Carmen Ribes-Koninckx, Nikhil Thapar, Frederic Gottrand, Rok Orel, Paolo Lionetti, Marc A Benninga
According to international guidelines, polyethylene glycol (PEG) is the laxative of first choice in the treatment of functional constipation in children, both for disimpaction and for maintenance treatment. PEG acts as an osmotic laxative and its efficacy is dose dependent. PEG is highly effective, has a good safety profile and is well tolerated by children. Only minor adverse events have been reported. Overall the use of PEG in children has been reported to be safe, although in patients predisposed to water and electrolyte imbalances monitoring of serum electrolytes should be considered...
August 2, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28777125/successful-use-of-sirolimus-in-children-with-large-mesenteric-lymphatic-lesions
#9
Swellen Gastineau, Giulia Paolella, Cécile Talbotec, Virginie Verkarre, Frédérique Sauvat, Olivier Goulet, Sylvie Fraitag, Florence Lacaille
No abstract text is available yet for this article.
August 2, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753190/new-celiac-icebergs-are-spotted-other-are-slowly-emerging
#10
Carlo Catassi
No abstract text is available yet for this article.
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753189/commentary-to-article-entitled-vitamin-d-deficiency-is-not-associated-with-growth-or-the-incidence-of-common-morbidities-among-tanzanian-infants
#11
Diana R Mager
No abstract text is available yet for this article.
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753188/the-relationship-between-child-mortality-rates-and-prevalence-of-celiac-disease
#12
Federico Biagi, Alberto Raiteri, Annalisa Schiepatti, Catherine Klersy, Gino R Corazza
OBJECTIVES: Some evidence suggests that prevalence of celiac disease in the general population is increasing over time. Since the prognosis of celiac disease was a dismal one before discovering the role of gluten, our aim was to investigate a possible relationship between children under five-mortality rates and prevalence rates of celiac disease. METHODS: Thanks to a literature review, we found 27 studies performed in 17 different countries describing the prevalence of celiac disease in schoolchildren; between 1995 and 2011, 4 studies were performed in Italy...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753187/slc5a1-mutations-in-saudi-arabian-patients-with-congenital-glucose-galactose-malabsorption
#13
Yasir Al-Suyufi, Khalid Al-Saleem, Ali Al-Mehaidib, Mohammed Banemai, Wajeeh M Aldekhail, Abdulhakim Al-Muhandes, Manal Mohammed, Rabab Allam, Amani Jambi, Khushnooda Ramzan, Faiqa Imtiaz
Congenital glucose-galactose malabsorption (cGGM) is a rare autosomal recessive disorder, caused by mutations in the SLC5A1 gene, encoding the sodium/glucose co-transporter 1 (SGLT1) which may result in severe life-threatening osmotic diarrhea due to the accumulation of unabsorbed sugars in the intestinal lumen. If treated early with elimination of glucose and galactose from the diet, patients usually recover and develop normally. We present clinical and molecular data from 16 unrelated cGGM diagnosed Saudi patients from consanguineous families with majority of them having previous positive family history of cGGM...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753186/bioactive-whey-protein-concentrate-and-lactose-stimulate-gut-function-in-formula-fed-preterm-pigs
#14
Yanqi Li, Duc Ninh Nguyen, Karina Ryom, Anders D Andersen, Thomas Thymann, Dereck E W Chatterton, Stig Purup, Anne B Heckmann, Stine B Bering, Per T Sangild
OBJECTIVE: Formula feeding is associated with compromised intestinal health in preterm neonates compared with maternal milk, but the mechanisms behind this are unclear. We hypothesized that the use of maltodextrin and whey protein concentrates (WPCs) with reduced bioactivity due to thermal-processing are important factors. METHOD: Ninety-two caesarean-delivered preterm pigs were fed increasing doses of formulas for 5 days (24-120 mL/kg/d). In Experiment 1, four groups of pigs (n = 15-16) were fed lactose- or maltodextrin-dominant formulas (lactose/maltodextrin ratios 3:1 or 1:3, respectively), containing WPC with either high or low levels of IgG (WPC1 or WPC2, respectively)...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753185/pediatric-gastroesophageal-reflux-disease-systematic-review-on-prognosis-and-prognostic-factors
#15
Maartje M J Singendonk, Merit M Tabbers, Marc A Benninga, Miranda W Langendam
In this systematic review, we summarize the evidence on prognosis and prognostic factors of pediatric GERD. A structured search of Embase and MEDLINE/PubMed (inception to April 2016) yielded 5365 references; four publications met our inclusion criteria (risk of bias moderate-high). Definitions and outcome measures varied widely between studies. The percentage of children with a diagnosis of GERD with esophagitis that had persisting symptoms and/or were on anti-reflux medication at follow-up (12 months to >5 years) ranged from 23% (weekly symptoms) to 68% (anti-reflux medication), depending on definition used...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753184/radiation-exposure-and-attributable-cancer-risk-in-patients-with-esophageal-atresia
#16
Yasmine Yousef, Robert Baird
OBJECTIVES: Cases of esophageal carcinoma have been documented in survivors of esophageal atresia (EA). Children with EA undergo considerable amounts of diagnostic imaging and consequent radiation exposure potentially increasing their lifetime cancer mortality risk. This study evaluates the radiological procedures performed on patients with EA and estimates their cumulative radiation exposure and attributable lifetime cancer mortality risk. METHODS: Medical records of patients with EA managed at a tertiary care center were reviewed for demographics, EA subtype and number and type of radiological investigations...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753183/serum-n-6-and-n-9-fatty-acids-correlate-with-serum-igf-1-and-growth-up-to-four-months-of-age-in-healthy-infants
#17
Emma Kjellberg, Josefine Roswall, Stefan Bergman, Birgitta Strandvik, Jovanna Dahlgren
OBJECTIVES: To study the relationship between insulin-like growth factor 1 (IGF-1), serum phospholipid fatty acids and growth in healthy full-term newborns during infancy. METHODS: Prospective observational study of a population-based Swedish cohort comprising 126 healthy, term infants investigating cord blood and serum at two days and four months of age for IGF-1 and phospholipid fatty acid profile and breast milk for fatty acids at two days and four months, compared to anthropometric measurements (SDS)...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753182/early-onset-of-wilson-disease-diagnostic-challenges
#18
Anna Wiernicka, Maciej Dądalski, Wojciech Jańczyk, Diana Kamińska, Magdalena Naorniakowska, Anna Hüsing-Kabar, Hartmut Schmidt, Piotr Socha
OBJECTIVES: To analyze the clinical presentations, diagnosis and treatment of patients aged ≤ 5 years with early onset Wilson disease (WD). METHODS: Data from 143 pediatric patients with WD treated at our center between January 1996 and November 2015 were retrospectively analyzed. RESULTS: A review of the 143 pediatric patients with WD identified 21 (10 girls, 11 boys) with first symptoms or abnormal liver function test results at age ≤5 years...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753181/real-life-anti-tumour-necrosis-factor-experience-in-500-paediatric-united-kingdom-inflammatory-bowel-disease-patients
#19
Victoria M Merrick, Kajal Mortier, Linda J Williams, Rafeeq Muhammed, Marcus Kh Auth, Mamoun Elawad, John Me Fell, R Mark Beattie, Sabarinathan Loganathan, Franco Torrente, Mary-Anne Morris, Charles Charlton, Nick M Croft, Astor Rodrigues, Mark Furman, Babu Vadamalayan, Huw Jenkins, Veena Zamvar, Sally G Mitton, Sonny Chong, Mike Cosgrove, Anthony Akobeng, David C Wilson, Richard K Russell
OBJECTIVES: To measure the effectiveness, safety and use of anti-Tumour necrosis Factor (TNF) therapy in paediatric inflammatory bowel disease (PIBD) in the United Kingdom (UK). METHODS: Prospective UK audit of patients newly starting anti-TNF therapy. Disease severity was assessed using Physician Global Assessment (PGA) +/or the Paediatric Crohn's Disease Activity Index (PCDAI). RESULTS: 37 centres participated (23 of 25 specialist PIBD sites)...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28753180/mass-screening-for-celiac-disease-among-school-aged-children-toward-exploring-celiac-iceberg-in-saudi-arabia
#20
Abdulrahman Al-Hussaini, Riccardo Troncone, Musa Khormi, Muath AlTuraiki, Wahid Alkhamis, Mona Alrajhi, Thana Halal, Mosa Fagih, Sahar Alharbi, Muhammed Salman Bashir, Aziz Elchentoufi
OBJECTIVES: We conducted this mass screening study to determine the prevalence of celiac disease (CD) and characterize the celiac iceberg among Saudi pediatric population in Riyadh, the capital city of Saudi Arabia. METHODS: Over the study period (January 2014 to June 2016), we have conducted a cross-sectional, mass screening, IgA-tissue transglutaminase (TTG-IgA)-based study on 7930 Saudi students from primary and intermediate schools in Riyadh. Students with positive TTG-IgA (> 20 U/L) were called in the hospital to undergo a repeat of TTG-IgA; in those with borderline positive TTG-IgA (20-60 U/L) IgA-endomyseal antibody (EMA-IgA) test was performed...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
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