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Journal of Pediatric Gastroenterology and Nutrition

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https://www.readbyqxmd.com/read/28207476/faecal-calprotectin-in-cystic-fibrosis-and-it-s-relation-to-disease-parameters-a-longitudinal-analysis-over-12-years
#1
Helmut Ellemunter, Alexander Engelhardt, Katharina Schüller, Gratiana Steinkamp
OBJECTIVES: Faecal calprotectin (FC) is a marker of inflammation in the intestinal tract. We assessed FC levels longitudinally in patients with cystic fibrosis (CF) and evaluated the relation between FC results and relevant markers of disease. METHODS: Calprotectin was measured in faecal samples starting in 2003 and values were stored in the centre's patient database. In this retrospective analysis we searched for associations of FC concentrations with disease severity and progression...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28207475/temporal-trend-of-pediatric-inflammatory-bowel-disease-analysis-of-national-registry-data-2004-2013-in-japan
#2
Takashi Ishige, Takeshi Tomomasa, Reiko Hatori, Maiko Tatsuki, Yoshiko Igarashi, Kazuhiko Sekine, Hirokazu Arakawa
Increased incidence and prevalence of pediatric inflammatory bowel disease (IBD) have been reported in Western countries. However, changes in the prevalence of pediatric IBD in Asian countries remain unclear. We evaluated the changes in the prevalence of IBD among Japanese adults and children from 2004-2013, by using the Japanese national registry data of patients receiving financial aid. Data from children (aged 0-19 years) were compared with those from young adults (aged 20-39 years).In 2004, age-standardized prevalences of CD and UC among children were 4...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28207474/risk-of-colectomy-in-patients-with-pediatric-onset-ulcerative-colitis
#3
Firas Rinawi, Amit Assa, Rami Eliakim, Yael Mozer Glassberg, Vered Nachmias Friedler, Yaron Niv, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
OBJECTIVES: Data describing the incidence and risk factors for colectomy in pediatric ulcerative colitis (UC) is inconsistent. Our aim was to describe the colectomy rate and to identify risk factors associated with colectomy in a large cohort of children with UC with long term follow up. METHODS: We performed a retrospective chart review of pediatric UC cases that were diagnosed at Schneider Children's Medical Center of Israel between 1981 to 2013. Potential predictors for colectomy including age at diagnosis, gender, disease extent, severity indices and different therapeutic regimens during disease course were assessed...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28181921/feed-induced-dystonias-in-children-with-severe-central-nervous-system-disorders
#4
Santosh Mordekar, Manjula Velayudhan, David I Campbell
Dystonias can arise from any painful stimuli in neurologically disabled children. Classically, feed induced dystonias from mediastinal pain due to severe gastroesophageal reflux disease are described as Sandifer's spasm. We report a case series of 12 severely neurologically impaired children with enteral feed induced dystonias. Intestinal dysmotility was demonstrated in several. Improvements are seen with jejunal feeds or gut rest with Total Parenteral Nutrition. Use of parenteral nutrition in children with severe neurodisability requires thorough discussion with patient groups and commissioners to give clinicians guidelines to standardise care...
February 8, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28169975/simple-urine-test-to-evaluate-adherence-to-oral-5-asa-in-teenagers-with-ulcerative-colitis-proof-of-concept
#5
Alie Dijkstra, Daan J Touw, Patrick F van Rheenen
OBJECTIVES: 5-aminosalicylic acid (5-ASA) is an important maintenance drug for patients with ulcerative colitis. A proportion of the ingested dose is excreted in the urine. Measuring 5-ASA and its metabolites in urine requires mass spectrometry, which is not widely available for this purpose. Urinary 5-ASA can be measured by colorimetry using the serum salicylic acid assay and is a surrogate marker of recent 5-ASA ingestion. We evaluated whether measuring 5-ASA in first morning voids or in random spot urine samples correctly identifies teenagers with poor adherence to oral 5-ASA...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28169974/f-calprotectin-and-blood-markers-correlate-to-quality-of-life-in-pediatric-inflammatory-bowel-disease
#6
Katrine Carlsen, Christian Jakobsen, Thomas Kallemose, Anders Paerregaard, Lene Buhl Riis, Pia Munkholm, Vibeke Wewer
OBJECTIVES: Our aim was to investigate predictors of Health Related Quality of Life (HRQoL) with respect to changes in disease parameters over time in children with Inflammatory Bowel Disease (IBD). METHODS: This was a prospective longitudinal study examining the association between HRQoL (IMPACT III) and symptom scores (PCDAI, abbrPUCAI), fecal calprotectin (FC) measures and blood analyses (C-reactive protein [CRP], erythrocyte sedimentation-rate [ESR], orosomucoid [ORM], albumin [ALB], hemoglobin [HB] and vitamin-D [VIT-D]) in a cohort of 10-17 years old IBD patients...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28169973/fecal-calprotectin-and-eosinophil-derived-neurotoxin-in-healthy-children-between-0-12-years
#7
María Roca, Ana Rodriguez Varela, Ester Donat, Francisco Cano, David Hervas, Ana Armisen, Maria Jose Vaya, Anders Sjölander, Carmen Ribes-Koninckx
OBJECTIVES: In young children, the use of fecal calprotectin (fCP) as a biomarker is limited because reference values have not been widely accepted up to now. Moreover, reference values for fecal eosinophil-derived neurotoxin (fEDN) in children have not been established. The aim of this study was to investigate fCP and fEDN levels in young healthy children in order to establish reference values. METHODS: Stool samples were obtained from healthy children aged 0 to 12 years...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28169972/breastfeeding-and-infant-hospitalisation-for-infections-large-cohort-and-sibling-analysis
#8
Ketil Størdal, Karen M Lundeby, Anne Lise Brantsæter, Margaretha Haugen, Britt Nakstad, Nicolai A Lund-Blix, Lars C Stene
BACKGROUND: Breastfeeding may protect against infections, but its optimal duration remains controversial. We aimed to study the association of the duration of full and any breastfeeding with infections the first 18 months of life. METHODS: The Norwegian Mother and Child study (MoBa) is a prospective birth cohort which recruited expecting mothers giving birth from 2000-2009. We analyzed data from the full cohort (n = 70 511) and sibling sets (n = 21 220) with parental report of breastfeeding and infections...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28169971/health-related-quality-of-life-in-pediatric-patients-with-chronic-hepatitis-b-living-in-the-united-states-and-canada
#9
Sarah Jane Schwarzenberg, Simon C Ling, Yona Keich Cloonan, Hsing-Hua S Lin, Donna M Evon, Karen F Murray, Norberto Rodriguez-Baez, Philip Rosenthal, Jeffrey Teckman, Kathleen B Schwarz
OBJECTIVES: To determine if selected socio-demographic and HBV-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with hepatitis B virus (HBV). METHODS: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire (CHQ) at study entry. Caregivers of children 5- < 10 years completed the parent-reported PF50; youth 10- < 18 years completed the child-reported CF87...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28169970/second-line-agents-in-pediatric-patients-with-autoimmune-hepatitis-a-systematic-review-and-meta-analysis
#10
Andréanne N Zizzo, Pamela L Valentino, Prakesh S Shah, Binita M Kamath
BACKGROUND AND AIMS: Ten to 20% of children with autoimmune hepatitis require second-line therapy to achieve remission. Although current guidelines exist on first-line management, evidence for second-line therapy in treatment-refractory patients is lacking. Our aim was to perform a systematic review and meta-analysis of the efficacy and safety of second-line treatments used in this population. METHODS: Electronic and manual searches were employed to identify potential studies for inclusion...
February 4, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28151769/per-oral-endoscopic-myotomy-in-a-child-with-achalasia-cardia
#11
Zaheer Nabi, Mohan Ramchandani, D Nageshwar Reddy
No abstract text is available yet for this article.
February 1, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28151768/digital-evaluation-of-the-biliopancreatic-tree-cases-from-the-pediatric-ercp-database-initiative-consortium
#12
Douglas S Fishman, Matthew J Giefer, Bradley Barth, David M Troendle
No abstract text is available yet for this article.
February 1, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28151767/increasing-incidence-and-altered-presentation-in-a-population-based-study-of-pediatric-celiac-disease-in-north-america
#13
Eyad Almallouhi, Katherine S King, Bhavisha Patel, Chung Wi, Young J Juhn, Joseph A Murray, Imad Absah
OBJECTIVES: Celiac disease (CD) is a common immune-mediated disorder that affects up to 1% of the general population. Recent reports suggest that the incidence of CD has reached a plateau in many countries. We aim to study the incidence and altered presentation of childhood CD in a well-defined population. METHODS: Using the Rochester Epidemiology Project, we retrospectively reviewed Mayo Clinic and Olmsted Medical Center medical records from January 1994 to December 2014...
February 1, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28141681/osseous-metaplasia-in-a-juvenile-rectal-polyp
#14
Harry Russell Haynes, Anthony E Wiskin, Dharam Basude, Elise Gradhand
No abstract text is available yet for this article.
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28141680/monozygotic-twin-cases-of-xiap-deficiency-syndrome
#15
Soon Chul Kim
No abstract text is available yet for this article.
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28141679/abdominal-arterial-anomalies-in-children-with-alagille-syndrome-surgical-aspects-and-outcomes-of-liver-transplantation
#16
Jules Kohaut, Romain Pommier, Florent Guerin, Danièle Pariente, Emmanuel Jacquemin, Hélène Martelli, Sophie Branchereau
OBJECTIVES: Angiogenic defects secondary to gene mutations of JAG1 and NOTCH2, causing arterial anomalies in Alagille syndrome (AGS), are well described in the literature. The study analyzes the frequency of abdominal arterial anomalies in children with AGS with an emphasis on outcomes following liver transplantation (LT). METHODS: Between 1988 and 2013, 242 children with AGS were treated at our institution. We performed a retrospective analysis of 55 who underwent LT during the study period...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28141678/frequency-of-severe-infusion-reactions-associated-with-outpatient-infusion-of-infliximab-without-pre-medications
#17
Stephanie Q Hutsell, May Wu, K T Park
In this report, we describe incremental changes, over a two year period at a single center with the administration of maintenance infliximab infusions. Given practice-driven changes consisting of one-hour infusions and omission of pre-medications, we aimed to investigate if these changes contributed to severe infusion reactions. We reviewed approximately 900 infliximab infusions in a pediatric ambulatory infusion center from January 1, 2014-December 31, 2015 for severe adverse reactions requiring either rescue epinephrine or a code blue or 'rapid response' activation...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28141677/the-unique-inflammatory-bowel-disease-phenotype-of-pediatric-primary-sclerosing-cholangitis-a-single-center-study
#18
Henry Shiau, Faith D Ihekweazu, Mansi Amin, Tatiana Fofanova, Tamir Miloh, Richard Kellermayer
BACKGROUND: In adults, primary sclerosing cholangitis (PSC), a cholestatic liver disease characterized by inflammation/fibrosis of intra/extra-hepatic bile ducts, associates with a milder form of inflammatory bowel disease (IBD), particularly ulcerative colitis (UC). The pediatric PSC-IBD phenotype is less well characterized. METHODS: We performed a retrospective, single-center study examining PSC-IBD patients at Texas Children's Hospital (TCH) between 2000-2015...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28141676/nutritional-assessment-and-status-of-hospitalized-infants
#19
Misa Matsuyama, Kristie Bell, Melinda White, Karen Lawson, Michael David, Annabel Doolan, Alwyn Todd
OBJECTIVES: Malnutrition during infancy has long-term adverse consequences for both physical and psychological development. Early detection of malnutrition among hospitalized infants is essential to provide optimal nutrition support. The primary aim of the present study was to investigate the nutritional status of hospitalized infants using 2 methods: the Subjective Global Nutritional Assessment (SGNA) and anthropometric measurement. We also investigated diagnostic category associated with nutritional status, the mean anthropometric z scores, and explored the association between malnutrition and nutrition focused variables...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28121648/changes-in-the-gut-microbiota-after-early-administration-of-oral-synbiotics-to-young-infants-in-india
#20
Dinesh S Chandel, Maria E Perez-Munoz, Fang Yu, Robert Boissy, Radhanath Satpathy, Pravas R Misra, Nidhi Sharma, Rama Chaudhry, Sailajanandan Parida, Daniel A Peterson, Ira H Gewolb, Pinaki Panigrahi
OBJECTIVES: We examined the changes in the developing gut microbiota of Indian infants enrolled in a colonization study of an oral synbiotic (L. plantarum and fructo-oligosaccharides) preparation. METHODS: Frozen stool samples were available from a previously published clinical study of the synbiotic preparation administered daily for seven days to full term Indian infants delivered by C-section. 16S rRNA gene sequencing of fecal bacterial community-DNA was done in 11 infants sampled at Day-7 and Day-60 of life...
January 25, 2017: Journal of Pediatric Gastroenterology and Nutrition
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