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Journal of Pediatric Gastroenterology and Nutrition

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https://www.readbyqxmd.com/read/30383579/peg-3350-versus-lactulose-for-treatment-of-functional-constipation-in-children-randomized-study
#1
Dorota Jarzębicka, Joanna Sieczkowska-Golub, Jaroslaw Kierkus, Piotr Czubkowski, Monika Kowalczuk-Kryston, Maciej Pelc, Dariusz Lebensztejn, Bartosz Korczowski, Piotr Socha, Grzegorz Oracz
OBJECTIVES: The aim of this study was to compare the clinical efficacy and tolerance of polyethylene glycol 3350 (PEG) and lactulose for the treatment of functional constipation in infants and children. METHODS: This randomized, multicenter study covered 12 weeks of treatment and 4 weeks of follow-up of patients with functional constipation. Patients were randomized (central randomization) to receive either PEG or lactulose. The primary end points were the number of defecations per week after 12 weeks of treatment and improvement in stool consistency of at least 2 points in the Bristol scale...
October 31, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30358742/epidemiology-of-pediatric-acute-pancreatitis-in-taiwan-a-nationwide-population-based-study
#2
Yu-Jyun Cheng, Hsin-Yi Yang, Ching-Fang Tsai, Jen-Shyang Lin, Hung-Chang Lee, Chun-Yan Yeung, Solomon Chih-Cheng Chen
OBJECTIVE: Pediatric acute pancreatitis (AP) may be different from adult AP in various respects. This study focuses on the epidemiology and medical resource use of pediatric AP in Taiwan. METHODS: Patients aged 0-18 years with AP were identified from the Taiwan National Health Insurance Research Database based on the International Classification of Diseases, Ninth Revision (ICD-9) code of AP 577.0. The medical resource use was measured by length of hospital stay (LOS) and hospital charges...
October 24, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30358741/biliary-atresia-relevant-human-ipscs-recapitulate-key-disease-features-in-a-dish
#3
Lipeng Tian, Zhaohui Ye, Kim Kafka, Dylan Stewart, Robert Anders, Kathleen B Schwarz, Yoon-Young Jang
Biliary atresia (BA) is the most common cause of pediatric end-stage liver disease and the etiology is poorly understood. There is no effective therapy for BA partly due to lack of human BA models. Towards developing in vitro human models of BA, disease-specific iPSCs from 6 BA patients were generated using non-integrating episomal plasmids. In addition, to determine the functional significance of BA-susceptibility genes identified by genome wide association studies (GWAS) in biliary development, a genome-editing approach was used to create iPSCs with defined mutations in these GWAS BA loci...
October 24, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30358740/quantitative-analysis-of-apparent-diffusion-coefficient-for-disease-assessment-in-paediatric-inflammatory-bowel-disease
#4
Alessandra Scionti, Marco Di Maurizio, Massimo Basile, Azzurra Bernardini, Mario Miccoli, Paolo Lionetti, Claudio Defilippi, Davide Caramella
OBJECTIVE: To establish an apparent diffusion coefficient (ADC) cut-off value to classify active and non-active lesions in inflammatory bowel disease. METHODS: We reviewed 167 paediatric Magnetic Resonance Enterographies (MRE) executed for suspected inflammatory bowel disease by using a 1.5- and 3-tesla scanner. We assessed the presence and activity of the disease by using morphologic and functional parameters such as the ADC. Each patient could have more than one examinations...
October 24, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30358739/pediatric-feeding-disorder-consensus-definition-and-conceptual-framework
#5
Praveen Goday, Susanna Y Huh, Alan Silverman, Colleen Taylor Lukens, Pamela Dodrill, Sherri Shubin Cohen, Amy L Delaney, Mary Beth Feuling, Richard J Noel, Erika Gisel, Amy Kenzer, Daniel B Kessler, Olaf Kraus de Camargo, Joy Browne, James A Phalen
Pediatric feeding disorders lack a universally accepted definition. Feeding disorders require comprehensive assessment and treatment of four closely-related, complementary domains (medical, psychosocial, and feeding skill-based systems and associated nutritional complications). However, previous diagnostic paradigms have typically defined feeding disorders using the lens of a single professional discipline and fail to characterize associated functional limitations that are critical to plan appropriate interventions and improve quality of life...
October 24, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30358738/a-systematic-review-of-probiotics-for-cystic-fibrosis-patients-moving-forward
#6
Lenycia de Cassya Lopes Neri, Monica Taminato, Luiz Vicente Ribeiro Ferreira da Silva Filho
BACKGROUND: Cystic fibrosis (CF) is associated with chronic respiratory disease and pancreatic insufficiency and results in the malabsorption of nutrients and intestinal inflammation. There is evidence that probiotic supplementation may impact the gastrointestinal and respiratory microbiota. This study aimed to categorize current evidence regarding the effects of supplementing with probiotics in CF patients on gastrointestinal and respiratory outcomes according to the type of intervention...
October 24, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30358737/are-all-breastfed-infants-equal-clustering-metabolomics-data-to-identify-predictive-risk-clusters-for-childhood-obesity
#7
Franca Fabiana Kirchberg, Veit Grote, Dariusz Gruszfeld, Piotr Socha, Ricardo Closa-Monasterolo, Joaquin Escribano, Elvira Verduci, Benedetta Mariani, Jean-Paul Langhendries, Pascale Poncelet, Berthold Koletzko, Christian Hellmuth
OBJECTIVES: Fetal and early life represent a period of developmental plasticity during which metabolic pathways are modified by environmental and nutritional cues. Little is known on the pathways underlying this multifactorial complex. We explored whether 6 months old breastfed infants could be clustered into metabolically similar groups and that those metabotypes could be used to predict later obesity risk. METHODS: Plasma samples were obtained from 183 breastfed infants aged 6-months participating in the European multicenter Childhood Obesity Project study...
October 24, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30334933/oral-pyridostigmine-responsive-visceral-myopathy-with-actg2-mutations-a-case-series
#8
Hyunjoo Lee, Sowon Park, Jung-Tak Oh, Hye Min Kim, Seung Kim, Jin-Sung Lee
No abstract text is available yet for this article.
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30334932/should-paediatricians-be-aware-of-cystic-echinococcosis-a-literature-review
#9
Chiara Tersigni, Elisabetta Venturini, Carlotta Montagnani, Leila Bianchi, Elena Chiappini, Maurizio de Martino, Luisa Galli
Among parasitic hepatic cystic lesions, the most common disease is represented by cystic echinococcosis, especially in high endemic countries. European epidemiology of cystic echinococcosis in children is very difficult to assess because of under-reporting but is increasing, because of high immigration flows from endemic countries and an increased awareness. Hydatidosis can be localized in every part of the body. The liver and lungs are the most common localizations in both children and adults. Multi-organ involvement is rarely reported in children...
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30334931/sustainable-positive-response-to-sirolimus-in-juvenile-polyposis-of-infancy
#10
Muriel Quaranta, Nolwenn Laborde, Audrey Ferrand, Marie Danjoux, Nathalie Vergnolle, Frédérick Barreau, Claire Racaud-Sultan, Emmanuel Mas
No abstract text is available yet for this article.
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30334930/clinical-and-genetic-study-of-children-with-peutz-jeghers-syndrome-identifies-a-high-frequency-of-stk11-de-novo-mutation
#11
Hong-Mei Zhao, Yong-Jia Yang, Jia-Qi Duan, Hong-Juan Ouyang, Li Liu, Li-Chun Yi, Thomas M Attard, Ding-You Li, Jie-Yu You
OBJECTIVES: The present study aims to identify the genotype-phenotype correlation in children with Peutz-Jeghers Syndrome (PJS) through the analysis of STK11 gene mutations in the context of clinical and pathological characteristics. METHOD: In this observational cohort study, the clinical characteristics of 18 families diagnosed with pediatric PJS were collected. Genomic DNA from the peripheral blood of affected children and their family members was collected. The coding region of STK11 was amplified by PCR and screened for mutation by Sanger sequencing...
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30334929/resting-energy-expenditure-in-patients-with-familial-dysautonomia-a-preliminary-study
#12
Bat-El Bar Aluma, Lucy Norcliffe-Kaufmann, Ifat Sarouk, Adi Dagan, Moshe Ashkenazi, Yael Bezalel, Daphna Vilozni, Avishay Lahad, Ori Efrati
OBJECTIVES: Familial dysautonomia (FD) is a rare hereditary sensory and autonomic neuropathy characterized by chronic lung disease and cyclic vomiting due to hyper-adrenergic crises. Most FD patients are in a depleted nutritional state; however the phenotype of the disease is quite different between patients, as for the severity of lung disease and the intensity and frequency of these pathognomonic crises. In this study we wanted to investigate whether resting energy expenditure (REE) levels are increased in this population, and if correlations exist between REE levels and phenotype severity...
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30334928/hepatotoxicity-of-statins-as-determined-by-serum-alanine-aminotransferase-in-a-pediatric-cohort-with-dyslipidemia
#13
Nirav K Desai, Michael M Mendelson, Annette Baker, Heather Harker Ryan, Suzanne Griggs, Meera Boghani, Elizabeth Yellen, Lucy Buckley, Mathew W Gillman, Justin P Zachariah, Dionne Graham, Maureen M Jonas, Sarah D de Ferranti
OBJECTIVE: To evaluate the hepatotoxicity of statins, as determined by serum alanine aminotransferase (ALT), in children and adolescents with dyslipidemia in real world clinical practice. STUDY DESIGN: Clinical and laboratory data were prospectively collected between September 2010 and March 2014. We compared ALT levels between patients prescribed versus not prescribed 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins), and then compared ALT before and after initiation of statins...
October 16, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320672/proton-pump-inhibitors-and-infant-pneumonia-other-lower-respiratory-tract-infections-national-nested-case-control-study
#14
Mei-Ling Blank, Lianne Parkin, Jiaxu Zeng, David Barson
No abstract text is available yet for this article.
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320671/proton-pump-inhibitors-and-infant-pneumonia-other-lower-respiratory-tract-infections-national-nested-case-control-study
#15
Carlos Alberto Velasco-Benítez
No abstract text is available yet for this article.
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320670/kidney-function-in-children-with-chronic-liver-disease
#16
Ulla B Berg, Antal Németh
No abstract text is available yet for this article.
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320669/food-protein-induced-enterocolitis-syndrome-data-from-a-multicenter-retrospective-study-in-spain
#17
Juan J Díaz, Beatriz Espín, Oscar Segarra, Gloria Domínguez-Ortega, Javier Blasco-Alonso, Beatriz Cano, Ana Rayo, Ana Moreno
OBJECTIVE: To describe clinical, epidemiological and management characteristics of food protein-induced enterocolitis syndrome (FPIES) cases in Spain. PATIENTS AND METHODS: Multicenter observational retrospective study. FPIES cases diagnosed in specialized units in Spain over 12 months in 2017 (January to December) according to the recently published international diagnostic criteria were included. RESULTS: One hundred and twenty patients (53...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320668/feeding-interventions-are-associated-with-improved-outcomes-in-children-with-laryngeal-penetration
#18
Daniel R Duncan, Kara Larson, Kathryn Davidson, Kara May, Reza Rahbar, Rachel L Rosen
OBJECTIVES: To determine if children with laryngeal penetration on videofluoroscopic swallow study (VFSS) who received feeding interventions (thickened liquids, change in liquid flow rate and/or method of liquid delivery) had improved symptoms and decreased hospitalizations compared to those without intervention. METHODS: We performed a retrospective cohort study of children under 2 years with laryngeal penetration on VFSS at our institution in 2015 to determine initial and follow-up VFSS findings, symptom improvement at follow-up, and hospitalization risk before and after VFSS...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320667/esophagitis-dissecans-superficialis-diagnosed-by-unsedated-transnasal-esophagoscopy
#19
Racha T Khalaf, Pooja Mehta, Mark Lovell, Joel A Friedlander
No abstract text is available yet for this article.
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/30320666/fecal-microbiota-transplant-for-recurrent-clostridium-difficile-infection-in-pediatric-inflammatory-bowel-disease
#20
Stanley Cho, Elizabeth Spencer, Robert Hirten, Ari Grinspan, Marla C Dubinsky
OBJECTIVES: Recurrent Clostridium difficile infection (RCDI) increases morbidity and mortality in patients with inflammatory bowel disease (IBD). Fecal microbiota transplant (FMT) is known to be very effective for RCDI in non-IBD patients with cure rates up to 91%. The same success rates of FMT have not been reported in IBD patients with RCDI, and the data in pediatrics is limited. We aimed to determine the effectiveness of FMT for RCDI in established pediatric IBD patients. METHODS: We performed a retrospective chart review of pediatric patients with IBD and RCDI (≥3 episodes) who underwent FMT via colonoscopy at a tertiary care IBD center...
October 12, 2018: Journal of Pediatric Gastroenterology and Nutrition
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