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Journal of Pediatric Gastroenterology and Nutrition

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https://www.readbyqxmd.com/read/28422812/randomized-double-blind-trial-of-ringer-s-lactate-versus-normal-saline-in-pediatric-acute-severe-diarrheal-dehydration
#1
Gayathri Bhuvaneswaran Kartha, Ramachandran Rameshkumar, Subramanian Mahadevan
OBJECTIVE: To compare the effectiveness of Ringer Lactate (RL) versus normal saline (NS) in the correction of pediatric acute severe diarrheal dehydration, as measured by improvement in clinical status and pH (≥7.35). METHODS: 68 children aged 1-month to 12-year with acute severe diarrheal dehydration (World Health Organization (WHO classification) were randomized into RL (n = 34) and NS-group (n = 34) and received 100 ml/kg of the assigned intravenous fluid according to WHO PLAN-C for the management of diarrheal dehydration...
April 18, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28422811/microbiota-environment-and-diet
#2
Mauro Batista de Morais, Carolina Santos Mello, Mirian Silva Carmo-Rodrigues, Humberto Bezerra Araújo Filho, Lígia Cristina Fonseca Lahoz Melli, Soraia Tahan, Antônio Carlos Campos Pignatari
No abstract text is available yet for this article.
April 18, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28422810/apropos-gut-microbiota-differences-in-children-from-distinct-socioeconomic-levels-living-in-the-1-same-urban-area-in-brazil
#3
Sheldon Waugh
No abstract text is available yet for this article.
April 18, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28422809/associations-between-dietary-intake-prior-to-6-months-of-age-and-rapid-weight-gain-among-hiv-exposed-uninfected-infants
#4
Daniela Neri, Fernanda C Oliveira, Aline M Carvalho, Gabriel A Somarriba, Gwendolyn B Scott, Tracie L Miller
INTRODUCTION: HIV-exposed, uninfected (HEU) infants are potentially at risk for cardiovascular disease due to in utero exposures. Feeding practices of the infant could compound this risk. However, few studies have evaluated dietary intake of HEU infants. We determined dietary factors associated with rapid weight gain (RWG) among HEU infants from birth to 6 months followed at the University of Miami HIV Screening Program. METHODS: In this cross-sectional analysis, logistic regression was used to determine dietary factors associated with RWG defined as a greater than 0...
April 18, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28422808/diagnosis-of-chronic-intestinal-pseudo-obstruction-megacystis-by-sequencing-the-actg2-gene
#5
Aubrey Milunsky, Clinton Baldwin, Xiaoying Zhang, Daniel Primack, Adrian Curnow, Jeff Milunsky
OBJECTIVES: The diagnosis of chronic intestinal pseudo-obstruction (CIPO) has depended on clinical features, manometry, and imaging. This report aimed to determine the efficacy of sequencing the ACTG2 gene for diagnosis. In addition, the goal was to determine how often a mutation would be found in our randomly collected cohort of probands and those probands published previously. METHODS: Whole exome sequencing was performed in 4 probands with CIPO. Subsequently, only the ACTG2 gene was sequenced in another 24 probands (total 28)...
April 18, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28403036/commercial-probiotic-products-a-call-for-improved-quality-control-a-position-paper-by-the-espghan-working-group-for-probiotics-and-prebiotics
#6
Sanja Kolaček, Iva Hojsak, Roberto Berni Canani, Alfredo Guarino, Flavia Indrio, Rok Orel, Bruno Pot, Raanan Shamir, Hania Szajewska, Yvan Vandenplas, Johannes van Goudoever, Zvi Weizman
: Probiotics have been proposed for a number of indications ranging from the hypothetical long term immunomodulatory effects to proven benefits in the management of different clinical conditions.An increasing number of commercial products containing probiotics are available. In those products, irrespective if it is food, food supplement, medical food or drug, the probiotic microorganisms have to be present in a sufficient number by the end of the shelf-life, to pass through the gastrointestinal tract resisting acid and bile, to colonize the gut, and to retain functional properties required to obtain the suggested beneficial effect...
April 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28403035/characterizing-and-defining-infantile-liver-failure
#7
Sheetal Ganju, Bikrant Bihari Lal, Rajeev Khanna, Vikrant Sood, Seema Alam
No abstract text is available yet for this article.
April 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28403034/national-study-of-off-label-proton-pump-inhibitor-use-among-new-zealand-infants-in-the-first-year-of-life-2005-2012
#8
Mei-Ling Blank, Lianne Parkin
OBJECTIVE: Off-label prescribing of proton pump inhibitors (PPIs) to infants to treat symptoms attributed to gastroesophageal reflux disease (GERD) is widely reported, despite evidence that PPIs are no more effective than placebo in relieving those symptoms. To initiate discussion about appropriate prescribing of these drugs for infants, we describe the characteristics of PPI use among infants in New Zealand. METHODS: In this population-based study we used routinely collected dispensing data to identify all children born between 2005 and 2012 who were dispensed a government-subsidized PPI (omeprazole, lansoprazole, pantoprazole) before their first birthday...
April 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28394847/a-boy-with-genital-lesions-in-course-of-crohn-s-disease
#9
Matteo Pavan, Giovanna Ferrara, Silvia Nider, Stefano Martelossi, Alessandro Ventura
No abstract text is available yet for this article.
April 8, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28394846/ultrasound-guided-liver-biopsies-in-children-a-single-center-experience-and-risk-factors-for-minor-bleeding
#10
Carlos Bilreiro, Maria José Noruegas, Isabel Gonçalves, Ângela Moreira
OBJECTIVES: To analyze the institution's experience in ultrasound-guided liver biopsies performed on children and identify risk factors for complications, following a previous study performed in our institution. METHODS: retrospective analysis of a consecutive series of ultrasound-guided pediatric liver biopsies, between 2011 and 2016. Demographic and anthropometric data, biopsy indications, INR and platelet count, biopsy technique, complications and pathologic outcomes were recorded...
April 8, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28379926/biomarkers-of-environmental-enteric-dysfunction-the-good-the-bad-and-the-ugly
#11
Lissette Jimenez, Christopher P Duggan
No abstract text is available yet for this article.
April 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28379925/medically-graded-honey-supplementation-formula-to-preterm-infants-as-a-prebiotic-a-randomized-controlled-trial
#12
Hany Aly, Reem N Said, Iman E Wali, Amany Elwakkad, Yssra Soliman, Alaa Reda Awad, Mahmoud A Shawky, Mohamed A Mohamed
OBJECTIVES: To assess the effect of medically-graded enteral honey supplementation on the intestinal microbiota, immune response, and somatic growth of preterm infants. METHODS: A prospective randomized controlled trial was conducted on preterm infants with gestational age ≤ 34 weeks and postnatal age > 3 days. After reaching 1/2 goal enteral feeds, medically-graded bee honey was added to milk at a dose of 5, 10, 15, and 0 g/day for two weeks in groups A, B, C and D respectively...
April 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28379924/a-public-health-and-data-crisis-you-can-help-solve-cpsc-s-critical-need-for-naspghan-s-data
#13
Marietta S Robinson
No abstract text is available yet for this article.
April 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28379923/serum-markers-of-necrotizing-enterocolitis-a-systematic-review
#14
Gianluca Terrin, Laura Stronati, Salvatore Cucchiara, Mario De Curtis
OBJECTIVE: To systematically review the diagnostic utility of serum biomarkers for the diagnosis of necrotizing enterocolitis (NEC). METHODS: We conducted an electronic and manual search of the available evidence. We included studies reporting data on the diagnostic accuracy of "serum" biomarkers for the diagnosis of NEC, available until January 2016. RESULTS: We selected 22 studies from the 1296 papers retrieved. Only S100 A8/A9 protein and apolipoprotein-CII showed high sensitivity (100% and 96...
April 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28362695/anxiety-associated-with-high-resolution-anorectal-manometry-in-pediatric-patients-and-parents
#15
Katherine Lamparyk, Lori Mahajan, Ashley Debeljak, Rita Steffen
High resolution anorectal manometry (HRM) is an increasingly common procedure performed in pediatric patients to rule out Hirschsprungs as well as assess anorectal function and sensation. The purpose of this study was to evaluate anxiety of patients and their parents associated with HRM. Pre-procedural anxiety was assessed by standardized questionnaire in all parents and children over the age of 8 and observed behavioral distress was recorded by the attending pediatric gastroenterologist. Thirty-five children (mean age = 7...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28362694/the-challenge-of-treating-children-with-hepatitis-c-virus-infection
#16
Giuseppe Indolfi, Claire Thorne, Manal H El-Sayed, Carlo Giaquinto, Regino P Gonzalez-Peralta
The development of oral hepatitis C virus direct acting antivirals has revolutionized the therapeutic field. Nowadays, multiple safe and highly effective antiviral regimens are commercially available to treat adults with hepatitis C infection. These new regimens for the first time, genuinely raise the prospects of eradicating hepatitis C virus. However, many challenges remain: from identifying infected individuals to optimizing treatment and ensuring global access to antiviral therapy to all population groups, including children...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28362693/quality-improvement-in-pediatric-endoscopy-a-clinical-report-from-the-naspghan-endoscopy-committee
#17
Robert E Kramer, Catharine M Walsh, Diana Lerner, Douglas Fishman
The current era of healthcare reform emphasizes the provision of effective, safe, equitable, high quality and cost effective care. Within the realm of gastrointestinal endoscopy in adults, renewed efforts are in place to accurately define and measure quality indicators across the spectrum of endoscopic care. In pediatrics, however, this movement has been less defined and lacks much of the evidence-base that supports these initiatives in adult care. A need, therefore, exists to help define quality metrics tailored to pediatric practice and provide a toolbox for the development of robust quality improvement programs within pediatric endoscopy units...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28362692/breast-milk-tgf%C3%AE-is-associated-with-neonatal-gut-microbial-composition
#18
Alexandra R Sitarik, Kevin R Bobbitt, Suzanne L Havstad, Kei E Fujimura, Albert M Levin, Edward M Zoratti, Haejin Kim, Kimberley J Woodcroft, Ganesa Wegienka, Dennis R Ownby, Christine L M Joseph, Susan V Lynch, Christine C Johnson
OBJECTIVES: Breast milk is a complex bioactive fluid that varies across numerous maternal and environmental conditions. While breastfeeding is known to impact neonatal gut microbiome, the milk components responsible for this effect are not well-characterized. Given the wide range of immunological activity breast milk cytokines engage in, we investigated three essential breast milk cytokines and their association with early life gut microbiota. METHODS: A total of 52 maternal-child pairs were drawn from a racially diverse birth cohort based in Detroit, Michigan...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28362691/increase-of-intra-abdominal-adipose-tissue-in-pediatric-crohn-s-disease
#19
Klara Frivolt, Holger Hetterich, Tobias Schwerd, Mohammad-Samer Hajji, Philip Bufler, Eva Coppenrath, Sibylle Koletzko
OBJECTIVES: Recent evidence points towards an active immunological role of intra-abdominal adipose tissue in Crohn's disease (CD). We quantified the abdominal adipose tissue compartments using magnetic resonance imaging (MRI) in 27 pediatric CD patients compared with 14 controls undergoing MRI examination for other reasons. METHODS: Total (TAAT), subcutaneous (SCAT) and intra-abdominal (IAAT) adipose tissue areas were measured by semiautomatic segmentation on a transverse slice centered on the umbilicus (mean ± standard deviation in cm) using standard T1 weighted sequences...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28362690/perianal-pediatric-crohn-s-disease-is-associated-with-a-distinct-phenotype-and-greater-inflammatory-burden
#20
Amit Assa, Michal Amitai, Mary-Louise Greer, Denise A Castro, Ruth Cytter Kuint, Maria Martínez-León, Izabela Herman-Sucharska, Eva Coppenrath, Sudha Anupindi, Alexander Towbin, Douglas Moote, Osnat Konen, Li-Tal Pratt, Anne Griffiths, Dan Turner
BACKGROUND: Data on the outcomes of children with perianal Crohn's disease (pCD) are limited, although its presence is often used for justifying early use of biologics. We aimed to assess whether pCD in children is associated with more severe outcomes as found in adults. METHODS: Data were extracted from the ImageKids database, a prospective, multicenter, longitudinal cohort study. The study enrolled 246 children at disease onset or thereafter. All patients underwent comprehensive clinical, endoscopic, and radiologic evaluation at enrollment; 98 children had repeat evaluation at 18 months...
March 30, 2017: Journal of Pediatric Gastroenterology and Nutrition
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