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Journal of Pain: Official Journal of the American Pain Society

Shannon M Blakey, H Ryan Wagner, Jennifer Naylor, Mira Brancu, Ilana Lane, Meghann Sallee, Nathan A Kimbrel, Eric B Elbogen
The polytrauma clinical triad refers to the co-occurrence of chronic pain, traumatic brain injury (TBI), and posttraumatic stress disorder (PTSD). Despite research implicating dyadic relationships between these conditions and adverse outcomes, scant research has examined the polytrauma clinical triad's relation to suicide or violence. The present cross-sectional study was designed to examine whether this complex clinical presentation increases risk of suicidal ideation and violent impulses after accounting for other established risk factors...
March 8, 2018: Journal of Pain: Official Journal of the American Pain Society
Kai Karos, Jessica M Alleva, Madelon L Peters
Experimental pain research frequently relies on the recruitment of volunteers. However, because experimental pain research often involves unpleasant and painful sensations, it may be especially susceptible to sampling bias. That is, volunteers in experimental pain research might differ from nonvolunteers on several relevant variables that could affect the generalizability and external validity of the research. We conducted two studies to investigate potential sampling bias in experimental pain research. In Study 1 we assessed participants' (N = 275; Age: 17 to 30 years) perceived likelihood of participating in pain research...
March 5, 2018: Journal of Pain: Official Journal of the American Pain Society
Karin Bruun Plesner, Henrik Bjarke Vaegter
Fibromyalgia is a condition with chronic widespread pain and signs of generalized pain hypersensitivity. FM has previously been classified according to the ACR1990 criteria, where the presence of hypersensitivity is estimated by a tender point examination. Due to the limitations of these classification criteria, new diagnostic criteria have been proposed, abandoning this examination. This cross-sectional study investigated the prevalence of FM according to the revised 2016 FM criteria in a large cohort of chronic pain patients...
February 27, 2018: Journal of Pain: Official Journal of the American Pain Society
Yaping Ji, Bo Hu, Jiyun Li, Richard J Traub
Chronic stress produces maladaptive pain responses, manifested as alterations in pain processing and exacerbation of chronic pain conditions including irritable bowel syndrome. Female predominance, especially during reproductive years, strongly suggests a role of gonadal hormones. However, gonadal hormone modulation of stress-induced pain hypersensitivity is not well understood. In the present study, we tested the hypothesis that estradiol is pronociceptive and testosterone is antinociceptive in a model of stress-induced visceral hypersensitivity (SIVH) in rats by recording the visceromotor response to colorectal distention following a 3 day forced swim stress (FS) paradigm...
February 26, 2018: Journal of Pain: Official Journal of the American Pain Society
Saara Vuontisjärvi, Henna-Riikka Rossi, Sauli Herrala, Laure Morin-Papunen, Juha S Tapanainen, Salla Karjula, Jaro Karppinen, Juha Auvinen, Terhi T Piltonen
Previous studies have shown increased pain sensitivity in fertile-aged women with endometriosis in response to mechanical stimuli. As yet, population-based studies on the association of endometriosis with pain sensation and pain symptoms in late fertile age are lacking. The main objective of this population-based cohort study was to investigate whether a history of endometriosis is associated with altered pain sensation and musculoskeletal pain symptoms at age 46. Our data is derived from the Northern Finland Birth Cohort 1966, which contains postal questionnaire data (72% response rate) as well as clinical data assessing pressure-pain threshold (PPT) and maximal pain tolerance (MaxPTo)...
February 26, 2018: Journal of Pain: Official Journal of the American Pain Society
Matthew Scott Herbert, Niloofar Afari, J B Robinson, Andrew Listvinsky, Mark W Bondi, Julie Loebach Wetherell
Neuropsychological (NP) performance has been associated with psychosocial treatment outcomes in non-pain conditions, but has never been investigated in chronic pain. We performed a secondary analysis on the association of baseline NP performance with treatment outcomes among veterans with chronic pain (N = 117) undergoing an 8-week Acceptance and Commitment Therapy (ACT) intervention. Participants completed measures of pain interference, pain severity, quality of life, activity levels, depression, and pain-related anxiety at baseline, mid-treatment, and post-treatment...
February 26, 2018: Journal of Pain: Official Journal of the American Pain Society
Wesley P Gilliam, Julia R Craner, Julie L Cunningham, Michele M Evans, Connie A Luedtke, Eleshia J Morrison, Jeannie A Sperry, Larissa L Loukianova
Chronic pain is a major public health concern, and widespread use of prescription opioids for chronic pain has contributed to the escalating problem of opioid use disorder. Interdisciplinary pain rehabilitation programs (IPRP) can be highly effective in discontinuing opioids in patients with chronic pain while also improving functional status. This study sought to examine self-report and performance-based functional outcomes of two cohorts of patients enrolled in a three-week interdisciplinary pain rehabilitation program...
February 26, 2018: Journal of Pain: Official Journal of the American Pain Society
Elisa J de Koning, Erik J Timmermans, Natasja M van Schoor, Brendon Stubbs, Tessa N van den Kommer, Elaine M Dennison, Federica Limongi, Maria Victoria Castell, Mark H Edwards, Rocio Queipo, Cyrus Cooper, Paola Siviero, Suzan van der Pas, Nancy L Pedersen, Mercedes Sánchez-Martínez, Dorly J H Deeg, Michael D Denkinger
Pain is a key symptom of Osteoarthritis (OA) and has been linked to poor mental health. Pain fluctuates over time within individuals, but a paucity of studies have considered day-to-day fluctuations of joint pain in relation to affective symptoms in older persons with OA. This study investigated the relationship of both pain severity and within-person pain variability with anxiety and depression symptoms in 832 older adults with OA who participated in the European Project on OSteoArthritis (EPOSA): a six-country cohort study...
February 26, 2018: Journal of Pain: Official Journal of the American Pain Society
Anthony Park, Olivia Uddin, Ying Li, Radi Masri, Asaf Keller
Pain after spinal cord injury (SCI-Pain) is one of the most debilitating sequelae of SCI, characterized as relentless, excruciating pain that is largely refractory to treatments. While it is generally agreed that SCI-Pain results from maladaptive plasticity in the pain processing pathway that includes the spinothalamic tract and somatosensory thalamus, the specific mechanisms underlying the development and maintenance of such pain are yet unclear. However, accumulating evidence suggests that SCI-Pain may be causally related to abnormal thalamic disinhibition, leading to hyperactivity in the posterior thalamic nucleus (PO), a higher order nucleus involved in somatosensory and pain processing...
February 23, 2018: Journal of Pain: Official Journal of the American Pain Society
Heather D Simister, Gregg A Tkachuk, Barbara L Shay, Norah Vincent, Joseph J Pear, Ryan Q Skrabek
In this study, 67 participants (95% female) with fibromyalgia (FM) were randomly assigned to an online acceptance and commitment therapy (online ACT) + treatment as usual (TAU) protocol or a TAU control condition. Online ACT + TAU participants were asked to complete seven modules over an 8-week period. Assessments were completed at pre-treatment, post-treatment, and three-month follow-up periods and included measures of FM impact (primary outcome), depression, pain, sleep, 6-minute walk, sit-to-stand, pain acceptance (primary process variable), mindfulness, cognitive fusion, valued living, kinesiophobia, and pain catastrophizing...
February 23, 2018: Journal of Pain: Official Journal of the American Pain Society
Sarah L Withey, Carol A Paronis, Jack Bergman
Although the clinical application of opioids for pain management is often hindered by undesired behavioral impairment, preclinical assays of antinociception typically do not provide information regarding the behaviorally disruptive effects of opioids that may accompany their antinociceptive effects. To address this, we modified a warm water tail withdrawal procedure to determine concurrently the effects of opioids on tail withdrawal latency (antinociception) and indices of food-maintained operant behavior (rates of responding and reinforcement density) in squirrel monkeys...
February 22, 2018: Journal of Pain: Official Journal of the American Pain Society
Wei-En Wang, Arnab Roy, Gaurav Misra, Derek B Archer, Margarete C Ribeiro-Dasilva, Roger B Fillingim, Stephen A Coombes
Musculoskeletal pain changes how people move. Although experimental pain is associated with increases in the variability of motor output, it is not clear whether motor-evoked pain in clinical conditions is also associated with increases in variability. In the current study, we measured jaw force production during a visually guided force paradigm in which individuals with chronic jaw pain and control subjects produced force at 2% of their maximum voluntary contraction (MVC) (low target force level) and at 15% of their MVC (high target force level)...
February 22, 2018: Journal of Pain: Official Journal of the American Pain Society
Anthony Terrence O'Brien, Alicia Deitos, Yolanda Triñanes Pego, Felipe Fregni, Maria Teresa Carrillo-de-la-Peña
To study the characteristics of temporal summation (TS) and conditioned pain modulation (CPM) in fibromyalgia (FM) patients, we systematically searched Pubmed and EMBASE for studies using TS or CPM comparing FM patients to healthy controls. We computed Hedge's g, risk of bias, sensitivity analysis and meta-regression tests with 10000 Monte-Carlo permutations. Twenty-three studies (625 female/23 male FM patients and 591 female/81 male healthy controls) were included. The meta-analyses showed an effect size of 0...
February 15, 2018: Journal of Pain: Official Journal of the American Pain Society
Dianne J Crellin, Franz E Babl, Nick Santamaria, Denise Harrison
The Modified Behavioral Pain Scale (MBPS) was designed to assess procedural pain in infants and is considered valid for assessing immunisation pain. The aim of this study was to assess the practical and psychometric properties of the MBPS when applied to other commonly performed procedures. Twenty-six clinicians independently applied the MBPS scale to segments of video collected from 100 children aged six to 42 months undergoing one of four procedures in the emergency department. Positive correlation between MBPS and VASobs pain (r = 0...
February 14, 2018: Journal of Pain: Official Journal of the American Pain Society
Todd Jackson, Lin Su, Yang Wang
In this research, we examined effects of higher versus lower threat contexts on attention biases in more and less pain-fearful chronic pain subgroups via eye-tracking methodology. Within a mixed chronic pain sample (69 women, 29 men), biases in orienting and maintenance of visual attention were assessed during the standardized image pair presentation phase (2000ms) of a modified visual dot probe task featuring painful-neutral (P-N) image pairs (lower threat context) and a parallel task in which these P-N pairs cued potential pain (higher threat context)...
February 13, 2018: Journal of Pain: Official Journal of the American Pain Society
Pedro Alvarez, Paul G Green, Jon D Levine
Neonatal handling (NH) of male rat pups strongly attenuates stress response and stress-induced persistent muscle hyperalgesia in adults. Since female sex is a well-established risk factor for stress-induced chronic muscle pain, we explored whether NH provides resilience to stress-induced hyperalgesia in adult female rats. Rat pups underwent NH, or standard (control) care. Muscle mechanical nociceptive threshold was assessed before and after water avoidance (WA) stress, when they were adults. In contrast to males, NH produced only a modest protection against WA stress-induced muscle hyperalgesia in females...
February 9, 2018: Journal of Pain: Official Journal of the American Pain Society
Sangeeta C Ahluwalia, Karleen F Giannitrapani, Steven K Dobscha, Risa Cromer, Karl A Lorenz
The "Pain as the 5th Vital Sign" initiative intended to address undertreatment of pain by encouraging routine pain assessment and management. In the Veterans Health Administration (VHA), routine pain screening has been practiced in primary care for over a decade, but has not improved the quality of pain management as measured by several process indicators, and some have expressed concerns of potentially fostering undesirable use of prescription opioids. We sought to evaluate the consequences of routine pain screening on clinical practice...
February 5, 2018: Journal of Pain: Official Journal of the American Pain Society
Jennifer S Gewandter, Jenna Chaudari, Katarzyna B Iwan, Rachel Kitt, Sawsan As-Sanie, Gloria Bachmann, Quentin Clemens, H Henry Lai, Frank Tu, G Nicholas Verne, Katy Vincent, Ursula Wesselmann, QiQi Zhou, Dennis C Turk, Robert H Dworkin, Shannon M Smith
Chronic pain conditions occurring in the lower abdomen and pelvis are common, often challenging to manage, and can negatively affect health-related quality of life. Methodological challenges in designing randomized clinical trials (RCTs) for these conditions likely contributes to the limited number of available treatments. The goal of this systematic review of RCTs of pharmacologic treatments for irritable bowel syndrome and 3 common chronic pelvic pain conditions are to (1) summarize the primary endpoints and entry criteria and (2) evaluate the clarity of reporting of important methodological details...
February 2, 2018: Journal of Pain: Official Journal of the American Pain Society
Stephan Ott, Christian Maihöfner
Complex regional pain syndrome (CRPS) is a complex pain disorder that can emerge after limb trauma or a lesion in the peripheral nervous system. Typical features include continuing pain, sensory, vasomotor, sudomotor, motor and trophic changes as well as edema. These signs provide the basis of CRPS diagnosis. A detailed description of the signs, symptoms and medical history of CRPS could potentially facilitate an earlier and more accurate diagnosis. The aim of this study is to provide such a description, based on epidemiological measures, clinical presentation and a thorough description of pain sensations...
February 1, 2018: Journal of Pain: Official Journal of the American Pain Society
Weihua Ding, Zerong You, Shiqian Shen, Jinsheng Yang, Grewo Lim, Jason T Doheny, Shengmei Zhu, Yi Zhang, Lucy Chen, Jianren Mao
Orofacial neuropathic pain caused by trigeminal nerve injury is a debilitating condition with limited therapeutic options. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability and are involved in the development and maintenance of chronic pain. However, the effect of HCN channel activity in the Gasserian ganglion on trigeminal neuropathic pain has not been examined. We evaluated nociceptive behaviors after microinjection of the HCN channel blockers ZD7288 or ivabradine into the Gasserian ganglion in rats with trigeminal nerve injury...
January 31, 2018: Journal of Pain: Official Journal of the American Pain Society
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