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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/28864079/rubber-hand-illusion-increases-pain-caused-by-electric-stimuli
#1
Marta Siedlecka, Nadine Spychała, Marta Łukowska, Karolina Wiercioch, Michał Wierzchoń
The rubber hand illusion (RHI) has been shown to alter the experience of pain, although studies have yielded inconsistent results. In this experiment tested the influence of RHI on the intensity of pain caused by electric stimuli. Electric stimuli were delivered to participants' experimental and control hands before RHI induction (control condition) and afterwards (experimental condition), in a procedure that was double-blind in respect to location and strength of noxious stimulation All hands were covered during the stimulation to avoid the analgesic effect of seeing one's own body part...
August 29, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28847735/loss-of-temporal-inhibition-of-nociceptive-information-is-associated-with-aging-and-bodily-pain
#2
Kelly M Naugle, Yenisel Cruz-Almeida, Roger B Fillingim, Joseph L Riley
An age-related decline in endogenous pain inhibitory processes likely places older adults at an increased risk for chronic pain. Limited research indicates that older adults may be characterized by deficient offset analgesia, an inhibitory temporal sharpening mechanism that increases the detectability of minor decreases in noxious stimulus intensity. The primary purpose of the study was to examine age differences in offset analgesia in community-dwelling younger, middle-aged, and older adults. An additional aim of the study was to determine whether the magnitude of offset analgesia predicted self-reported bodily pain...
August 25, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28847734/improvement-in-the-spatial-distribution-of-pain-somatic-symptoms-and-depression-following-a-weight-loss-intervention
#3
Andrew Schrepf, Steven E Harte, Nicole Miller, Christine Fowler, Catherine Nay, David A Williams, Daniel J Clauw, Amy Rothberg
Weight loss is known to improve pain localized to weight bearing joints but it is not known how weight loss affects the spatial distribution of pain and associated somatic symptoms like fatigue. We sought to determine if weight loss using a low calorie diet improves pain, affect, and somatic symptoms commonly associated with chronic pain conditions in an observational study. We also documented changes in inflammatory markers in serum before and after weight loss. Participants were 123 obese individuals undergoing a 12-16 week calorie restriction weight loss intervention...
August 25, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28842370/the-effect-of-preoperative-intra-articular-methylprednisolone-on-pain-after-tka-a-randomized-double-blinded-placebo-controlled-trial-in-patients-with-high-pain-knee-osteoarthritis-and-sensitization
#4
Iben E Luna, Henrik Kehlet, Claus M Jensen, Thorbjørn G Christiansen, Thomas Lind, Snorre L Stephensen, Eske K Aasvang
In a randomized, double-blinded, placebo controlled trial, we investigated the postoperative analgesic effect of a single intra-articular injection of 40 mg methylprednisolone acetate (MP) administered one week prior to total knee arthroplasty (TKA). Forty-eight patients with high pain osteoarthritis (≥ 5 NRS during walk) and sensitization (pressure pain threshold < 250 kPa), aged 50 to 80 years and scheduled for primary unilateral TKA under spinal anaesthesia were included. The primary outcome was the proportion of patient with moderate/severe pain during a 5 meter walk test 24 hours postoperatively...
August 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28842369/old-friends-with-new-faces-are-sodium-channel-blockers-the-future-of-adjunct-pain-medication-management
#5
Ashley M Thomas, Timothy J Atkinson
Providers are being asked to decrease the emphasis and overutilization of long-term opioid therapy, but many are left without proper guidance on appropriate utilization of non-opioid therapies. Furthermore, therapeutic options are quite limited and many providers lack confidence in distinguishing available alternatives. Once patients have failed 1(st) line therapy, there is an apparent lack of knowledge on how to proceed with choosing subsequent therapy. To choose amongst alternative agents, an understanding of pharmacology, pharmacokinetics, and efficacy in targeting various pain conditions is necessary...
August 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28842368/validity-of-the-visual-trajectories-questionnaire-for-pain-vtq-pain
#6
Kate M Dunn, Paul Campbell, Kelvin P Jordan
Researchers have identified trajectories of pain derived using statistical techniques on longitudinal data. These trajectories have potential to be of use clinically but the repeated data collection required is currently impractical for such situations. Our aim was to investigate the validity of a self-report Visual Trajectories Questionnaire-Pain for pain. Analysis included participants from two prospective cohorts of people seeking primary health care for back pain (n=622). A question was developed asking people to classify their pain experience into one of a number of trajectories using visual and word descriptions...
August 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28842367/the-acquisition-and-extinction-of-fear-of-painful-touch-a-novel-tactile-fear-conditioning-paradigm
#7
Emma E Biggs, Ann Meulders, Amanda L Kaas, Rainer Goebel, Johan W S Vlaeyen
Fear of touch, due to allodynia and spontaneous pain, is not well-understood. Experimental methods to advance this topic are lacking, and therefore we propose a novel tactile conditioning paradigm. Seventy-six pain-free participants underwent acquisition in both a predictable and unpredictable pain context. In the predictable context, vibrotactile stimulation was paired with painful electrocutaneous stimulation (simulating allodynia). In the unpredictable context, vibrotactile stimulation was unpaired with pain (simulating spontaneous pain)...
August 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28802882/chronic-opioid-therapy-modifies-qst-changes-following-ketamine-infusion-in-chronic-pain-patients
#8
Dermot P Maher, Yi Zhang, Shihab Ahmed, Tina Doshi, Charlene Malarick, Kristin Stabach, Jianren Mao, Lucy Chen
The long-term effects of opioids on sensitization processes are believed to be mediated through the NDMA receptor. QST changes observed following a ketamine infusion have been previously described but the effect that chronic opioids will have is not known. The results of this prospective randomized factorial trial compared the thermal QST changes observed following a 0.05 mg/kg ketamine infusion or a saline placebo in chronic pain subjects who were either opioid-naïve or were chronically using opioids for chronic non-cancer pain are presented...
August 9, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28801070/methodological-considerations-for-the-temporal-summation-of-second-pain
#9
Nathanial R Eckert, Charles J Vierck, Corey B Simon, Sachell Calderon, Yenisel Cruz-Almeida, Roland Staud, Roger B Fillingim, Joseph L Riley
Temporal summation of second pain (TSSP) is a psychophysical indication of a central pain encoding mechanism, potentially enhanced in pathological pain conditions. Low-frequency repetitive stimulation of unmyelinated (C) nociceptors results in a progressive increase of pain intensity when thermal stimulation intensity remains constant. However, when using different methods of nociceptive delivery to the skin, regularity as well as rate of pain enhancement with repetition varies between experiments. Specifically, repetitive ramping up and down from a neutral to a painful temperature has produced weak and inconsistent pain summation...
August 9, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28801071/comparison-of-two-lumbar-manual-therapies-on-temporal-summation-of-pain-in-healthy-volunteers
#10
Charles W Penza, Maggie E Horn, Steven Z George, Mark D Bishop
The purpose of this study was to compare the immediate change in temporal summation of heat pain (TSP) between spinal manipulation (SMT) and spinal mobilization (MOB) in healthy volunteers. Ninety-two volunteers (24 males; 23.8 ± 5.3 years) were randomized to receive SMT, MOB or no treatment (REST) for one session. Primary outcomes were changes in TSP, measured at the hand and foot, immediately following the session. A planned subgroup analysis investigated effects across empirically derived TSP clusters. PRIMARY OUTCOME: There were no differences in the immediate change in TSP measured at the foot between SMT and MOB, however both treatments were superior to the REST condition...
August 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28778814/explicit-education-about-exercise-induced-hypoalgesia-influences-pain-responses-to-acute-exercise-in-healthy-adults-a-randomized-controlled-trial
#11
Matthew D Jones, Trinidad Valenzuela, John Booth, Janet L Taylor, Benjamin K Barry
The mechanisms through which acute exercise reduces pain (ie, exercise-induced hypoalgesia [EIH]) are poorly understood. This study aimed to determine if education about EIH affected pain responses after acute exercise in healthy adults. Participants received 15 minutes of education either about EIH (intervention, n = 20) or more general education about exercise and pain (control, n = 20). After this, the participants' knowledge and beliefs about exercise and pain were assessed. Pressure pain thresholds were then measured before and after 20 minutes of cycle ergometer exercise...
August 1, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28760648/racial-and-socioeconomic-disparities-in-disabling-chronic-pain-findings-from-the-health-and-retirement-study
#12
Mary R Janevic, Sara J McLaughlin, Alicia A Heapy, Casey Thacker, John D Piette
The U.S. National Pain Strategy calls for increased population research on "high impact chronic pain," i.e., longstanding pain that substantially limits participation in daily activities. Using data from the nationally-representative Health and Retirement Study (HRS), we investigated the prevalence of high-impact chronic pain in U.S. adults over age 50 overall and within population subgroups. We also explored sociodemographic variation in pain-related disability within specific activity domains. Data are from a subsample of HRS respondents (n=1,925) who were randomly selected for a supplementary pain module in 2010...
July 28, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28729215/development-of-the-parent-responses-to-school-functioning-questionnaire
#13
Brittany N Barber Garcia, Laura S Gray, Laura E Simons, Deirdre E Logan
Parents play an important role in supporting school functioning in youth with chronic pain, but no validated tools exists to assess parental responses to child and adolescent pain behaviors in the school context. Such a tool would be useful in identifying targets of change to reduce pain-related school impairment. The goal of this study was to develop and preliminarily validate the Parent Responses to School Functioning (PRSF) Questionnaire, a parent self-report measure of this construct. After initial expert review and pilot testing, the measure was administered to 418 parents of children (ages 6-17) seen for initial multidisciplinary chronic pain clinic evaluation...
July 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28711636/factors-influencing-long-term-opioid-use-among-opioid-naive-patients-an-examination-of-initial-prescription-characteristics-and-pain-etiologies
#14
Anuj Shah, Corey J Hayes, Bradley C Martin
The relationships between the initial opioid prescription characteristics and pain etiology with the probability of opioid discontinuation were explored in this retrospective cohort study using health insurance claims data from a nationally representative database of commercially insured patients in the United States. We identified 1,353,902 persons aged 14 years and older with no history of cancer or substance abuse, with new opioid use episodes and categorized them into 11 mutually exclusive pain etiologies...
July 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28711635/a-new-pupillary-measure-to-assess-pain-a-prospective-study
#15
David J Charier, Daniel Zantour, Vincent Pichot, Florian Chouchou, Jean-Claude M Barthelemy, Frederic Roche, Serge B Molliex
Pupillary diameter (PD) varies under the influence of both the sympathetic and parasympathetic systems, increasing proportionally to pain intensity. Such variations however should not be confused with pupillary fluctuations, which refer to the fast and permanent PD fluctuations induced by the ongoing interplay between the sympathetic and parasympathetic systems, which we propose to measure using the Variation Coefficient of Pupillary Diameter (VCPD). This study aimed first at correlating both PD, PD increase during a contraction, and VCPD, with pain as rated with the Numerical Rating Scale (NRS) during obstetrical labor, and then at comparing such correlations with one another...
July 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28709954/modulation-of-itch-by-conditioning-itch-and-pain-stimulation-in-healthy-humans
#16
Hjalte H Andersen, Antoinette I M van Laarhoven, Jesper Elberling, Lars Arendt-Nielsen
Little is known about endogenous descending control of itch. In chronic pain, descending pain inhibition is reduced as signified by lowered conditioned pain modulation. There are indications that patients with chronic itch may also exhibit reduced endogenous descending inhibition of itch and pain. This study aimed to investigate whether and the extent to which itch can be modulated by conditioning itch and pain stimuli. Twenty-six healthy volunteers participated. The study consisted of 5 conditions designed to systematically assess endogenous modulation of itch or pain: 1) itch-induced modulation of contralateral itch, 2) pain-induced modulation of contralateral itch, 3) pain-induced modulation of ipsilateral itch, 4) pain-induced modulation of contralateral pain, and 5) itch-induced modulation of contralateral pain...
July 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28709955/neonatal-injury-results-in-sex-dependent-nociceptive-hypersensitivity-and-social-behavioral-deficits-during-adolescence-without-altering-morphine-response
#17
Nikita N Burke, Tuan Trang
Neonatal injury is associated with persistent changes in sensory function and altered nociceptive thresholds that give rise to aberrant pain sensitivity in later life. While these changes are well documented in adult rodents, little is known about the consequences of neonatal injury during adolescence. Since adolescence is a critical developmental period during which persistent pain conditions can arise, we examined the impact of neonatal injury on nociception, social behavior and response to morphine in adolescent Sprague Dawley rats...
July 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28694148/intensity-dependence-of-auditory-evoked-potentials-in-primary-dysmenorrhea
#18
Bingren Zhang, You Xu, Wei He, Jiawei Wang, Hao Chai, Chanchan Shen, Qisha Zhu, Wei Wang
Some studies suggest that women with primary dysmenorrhea have distinct emotional or personality features. For example, they might exaggerate their responses to external stimuli, such as to intensity-increasing auditory stimuli. Fifteen women with primary dysmenorrhea and 15 healthy women were invited to undergo tests of the intensity dependence of auditory evoked potentials (IDAEP), the Functional and Emotional Measure of Dysmenorrhea, and the Plutchik-van Praag Depression Inventory. Study participants with dysmenorrhea showed higher Functional and Emotional scale scores and stronger IDAEP...
July 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28690001/synergistic-interaction-between-dexmedetomidine-and-ulinastatin-against-vincristine-induced-neuropathic-pain-in-rats
#19
Bilin Nie, Subo Zhang, Zhuxi Huang, Jingxiu Huang, Xiaodi Chen, Yaochao Zheng, Xiaohui Bai, Weian Zeng, Handong Ouyang
Antimicrotubulin chemotherapeutic agents such as vincristine (VCR), often induce peripheral neuropathic pain. It is usually permanent and seriously harmful to cancer patients' quality of life and can result in the hampering of clinical treatments. Currently, there is no definitive therapy, and many of the drugs approved for the treatment of other neuropathic pain have shown little or no analgesic effect. It is therefore vital to find new and novel therapeutic strategies for patients suffering from chemotherapeutic agent-induced neuropathic pain to improve patients' quality of life...
July 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28690000/-i-m-not-gonna-pull-the-rug-out-from-under-you-patient-provider-communication-about-opioid-tapering
#20
Marianne S Matthias, Nicole L Johnson, Cleveland G Shields, Matthew J Bair, Palmer MacKie, Monica Huffman, Stewart C Alexander
In response to increases in harms associated with prescription opioids, opioid prescribing has come under greater scrutiny, leading many healthcare organizations and providers to consider or mandate opioid dose reductions (tapering) for patients with chronic pain. Communicating about tapering can be difficult, particularly for patients on long-term opioids who perceive benefits and are using their medications as prescribed. Given the importance of effective patient-provider communication for pain management and recent health system-level initiatives and provider practices to taper opioids, this study used qualitative methods to understand communication processes related to opioid tapering, to identify best practices and opportunities for improvement...
July 6, 2017: Journal of Pain: Official Journal of the American Pain Society
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