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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/28219667/mild-social-stress-in-mice-produces-opioid-mediated-analgesia-in-visceral-but-not-somatic-pain-states
#1
M H Pitcher, R Gonzalez-Cano, K Vincent, M Lehmann, E J Cobos, T J Coderre, J M Baeyens, F Cervero
: Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in visceral versus somatic pain states, we studied the effects of a mild social stressor in either acute visceral or somatic pain states in mice. We show that the presence of an unfamiliar conspecific (stranger) in an adjacent cubicle of a standard transparent observation box produced elevated plasma corticosterone levels compared to mice tested alone, suggesting that the mere presence of a stranger is stressful...
February 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28196739/preschool-needle-pain-responding-establishing-normal
#2
Jordana A Waxman, Miranda G DiLorenzo, Rebecca R Pillai Riddell, David B Flora, Saul Greenberg, Hartley Garfield
: The current study sets forth to provide both descriptive data for preschool vaccination pain responding and examine longitudinal relationships over early childhood. Growth mixture modeling (GMM) was first used to describe stable subgroups of preschoolers based on their pain response patterns over 2-minutes post-needle. Secondly, a parallel-process growth curve model was used to assess the stability of acute pain responding from 12-months of age to preschool age. Specifically, we examined whether preschool pain-related distress or regulation could be predicted from 12-month acute pain responding...
February 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28188907/safety-pharmacokinetic-and-pharmacodynamic-study-in-healthy-subjects-of-oral-neo6860-a-modality-selective-trpv1-antagonist
#3
William Brown, Richard L Leff, Andrew Griffin, Stuart Hossack, Roxane Aubray, Philippe Walker, Dan A Chiche
: Most previous TRPV1 antagonist programs have been put on hold, mainly due on-target adverse events: hyperthermia and impaired noxious heat sensation. NEO6860 is a TRPV1 antagonist, blocking capsaicin activation of the target, with little or no effect against pH or heat activation. The hypothesis is that this pharmacological profile will translate into analgesia without undesired effects on the body temperature or heat-pain threshold. This phase I, double blind, placebo controlled, ascending dose study, included 64 subjects...
February 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28185925/modest-amounts-of-voluntary-exercise-reduce-pain-and-stress-related-outcomes-in-a-rat-model-of-persistent-hind-limb-inflammation
#4
M H Pitcher, F Tarum, I Z Rauf, L A Low, M C Bushnell
: Aerobic exercise improves outcomes in a variety of chronic health conditions, yet the support for exercise-induced effects on chronic pain in humans is mixed. While many rodent studies have examined the effects of exercise on persistent hypersensitivity, the vast majority employed forced exercise paradigms that are known to be highly stressful. Since stress can also produce analgesic effects, we studied how voluntary exercise, known to reduce stress in healthy subjects, alters hypersensitivity, stress and swelling in a rat model of persistent hind paw inflammation...
February 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28163234/what-s-in-a-name-the-case-of-emotional-disclosure-of-pain-related-distress
#5
Annmarie Cano, Liesbet Goubert
: Pain behavior plays a key role in many theoretical models of pain, with many of these models conceptualizing pain behaviors as potentially detrimental to patient functioning. We propose that a certain class of behaviors-talking to others about one's pain-related distress (i.e., emotional disclosures of pain-related distress)-can be distinguished from other behaviors traditionally conceptualized as pain behaviors. Emotional disclosures of pain-related distress include verbally disclosing one's anger, sadness, or worry about the pain and its impact to another person...
February 2, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161474/the-impact-of-parental-modeling-on-child-pain-responses-the-role-of-parent-and-child-sex
#6
Katelynn E Boerner, Christine T Chambers, Patrick J McGrath, Vincent LoLordo, Rudolf Uher
: Social modeling is a process by which pain behaviours are learned, and research has found parents act as models for their children's behaviour. Despite social learning theory predicting that same-sex models have greater impact, no experimental investigation to date has examined the role of sex of the model or observer in social learning of pediatric pain. The present study recruited 168 parent-child dyads (equal father-son, father-daughter, mother-son, and mother-daughter dyads) where children were generally healthy 6- to 8-year-olds...
February 1, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28153805/the-value-of-prognostic-screening-for-patients-with-low-back-pain-in-secondary-care
#7
Emma L Karran, Adrian C Traeger, James H McAuley, Susan L Hillier, Yun-Hom Yau, G Lorimer Moseley
: Prognostic screening in patients with low back pain (LBP) offers a practical approach to guiding clinical decisions. Whether screening is helpful in secondary care is unclear. This prospective cohort study in adults with LBP placed on outpatient clinic waiting lists, compared the performance of the short-form Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ), the PICKUP Tool (PICKUP) and the STarT Back Tool (SBT). We assessed predictive validity for outcome at 4-month follow-up, by calculating estimates of discrimination, calibration and overall performance...
January 30, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28131700/change-in-self-as-context-perspective-taking-occurs-in-acceptance-and-commitment-therapy-for-people-with-chronic-pain-and-is-associated-with-improved-functioning
#8
Lin Yu, Sam Norton, Lance M McCracken
: Acceptance and Commitment Therapy (ACT) is based on the Psychological Flexibility (PF) model, which includes a therapeutic process, referred to as "self-as-context" (SAC). This study investigates whether ACT is associated with an effect on SAC and whether this effect is linked to treatment outcomes in people with chronic pain. 412 adults referred to a pain management center participated in the study. Participants completed measures of treatment processes (SAC, pain acceptance) and outcomes (pain-related interference, work and social adjustment, depression) before treatment, upon completion of treatment, and at nine-month follow-up...
January 25, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28131699/longitudinal-and-temporal-associations-between-daily-pain-and-sleep-patterns-after-major-pediatric-surgery
#9
Jennifer A Rabbitts, Chuan Zhou, Arthi Narayanan, Tonya M Palermo
: Around 20% of children develop persistent pain after major surgery. Sleep disruption has been implicated as a predictor of children's acute postsurgical pain. However, perioperative sleep patterns have not been longitudinally assessed, and the role of sleep in persistence of postsurgical pain has not been explored. We aimed to examine sleep patterns over 4 months in children having major surgery, and temporal relationships between daily sleep and pain. Sixty children age 10-18 (M=14...
January 25, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28108386/trajectory-of-improvement-in-children-and-adolescents-with-chronic-migraine-results-from-the-cognitive-behavioral-therapy-and-amitriptyline-trial
#10
John W Kroner, James Peugh, Susmita M Kashikar-Zuck, Susan L LeCates, Janelle R Allen, Shalonda K Slater, Marium Zafar, Marielle A Kabbouche, Hope L O'Brien, Chad E Shenk, Ashley M Kroon Van Diest, Andrew D Hershey, Scott W Powers
: We compared headache frequency trajectories between clinical trial participants who received cognitive behavioral therapy plus amitriptyline (CBT+A) or headache education plus amitriptyline (HE+A) to determine if there was differential time course of treatment response between the groups. 135 patients (age 10-17) diagnosed with chronic migraine participated, attending 8 one-hour one-on-one CBT or HE sessions with a trained psychologist for 8 weekly sessions, 2 sessions at weeks 12 and 16, and a post-treatment visit at week 20...
January 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28108385/seeing-an-embodied-virtual-hand-is-analgesic-contingent-on-co-location
#11
Birgit Nierula, Matteo Martini, Marta Matamala-Gomez, Mel Slater, Maria V Sanchez-Vives
: Seeing one's own body has been reported to have analgesic properties. Analgesia has also been described when seeing an embodied virtual body co-located with the real one. However, there is a controversy regarding whether this effect holds true when seeing an illusory-owned body part, such as during the rubber-hand illusion. A critical difference between these paradigms is the distance between real and surrogate body part. Co-location of real arm and surrogate is possible in an immersive virtual environment, but not during illusory ownership of a rubber arm...
January 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28088507/patient-reported-outcomes-and-opioid-use-in-outpatients-with-chronic-pain
#12
Lisa R Witkin, David Zylberger, Neel Mehta, Madeleine Hindenlang, Christopher Johnson, Jacob Kean, Susan D Horn, Charles E Inturrisi
: The Weill Cornell Medical College (WCMC) Pain Registry database contains patient characteristics, treatments, and outcomes for a prospective cohort of 1159 chronic pain patients who were seen at the WCMC Pain Medicine outpatient clinic from 7/08/2011 to 12/10/2014. Patients aged 45-64 comprised 43% followed by age >=65 at 37%. Fifty-eight percent were female. Average pain intensity (Brief Pain Inventory) was reported as mild by 22.3% of patients, moderate by 34.7%, and severe by 43...
January 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28088506/linguistic-indicators-of-pain-catastrophizing-in-patients-with-chronic-musculoskeletal-pain
#13
Doerte U Junghaenel, Stefan Schneider, Joan E Broderick
: The present study examined markers of pain catastrophizing in the word use of patients with chronic pain. Patients (n = 71) completed the Pain Catastrophizing Scale and wrote about their life with pain. Quantitative word count analysis examined whether the essays contained linguistic indicators of catastrophizing. Bivariate correlations showed that catastrophizing was associated with greater use of first person singular pronouns, such as "I" (r = .27, p≤ .05) and pronouns referencing other people (r = 28, p≤ ...
January 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28088505/gaps-in-the-public-s-knowledge-about-chronic-pain-representative-sample-of-hispanic-residents-from-five-states
#14
Barbara J Turner, Yuanyuan Liang, Natalia Rodriguez, Melissa A Valerio, Andrea Rochat, Jennifer S Potter, Paula Winkler
: Educating the general public about chronic pain and its care is a national health priority. We evaluated knowledge, attitudes, and beliefs (KAB) of a five-state, population-based sample of Hispanics aged 35-75 without chronic pain, representing over 8.8 million persons. A web-based survey assessed KAB using an adapted version of the Survey of Pain Attitudes-Brief and self-reported knowledge about chronic pain (nothing, a little, a lot). In unweighted analyses of participants (n=346), mean age was 52...
January 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28089711/regulation-of-expression-of-hyperalgesic-priming-by-estrogen-receptor-alpha-in-the-rat
#15
Luiz F Ferrari, Dionéia Araldi, Jon D Levine
: Hyperalgesic priming, a sexually dimorphic model of transition to chronic pain, is expressed as prolongation of prostaglandin E2 (PGE2)-induced hyperalgesia by the activation of an additional pathway including an autocrine mechanism at the plasma membrane. The autocrine mechanism involves the transport of cAMP to the extracellular space, and its conversion to AMP and adenosine, by ecto-5'phosphodiesterase and ecto-5'nucleotidase, respectively. The end product, adenosine, activates A1 receptors, producing delayed onset prolongation of PGE2 hyperalgesia...
January 9, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28069521/validity-of-simplified-versus-standard-self-report-measures-of-pain-intensity-in-preschool-aged-children-undergoing-venipuncture
#16
Anthony Emmott, Nicholas West, Guohai Zhou, Dustin Dunsmuir, Carolyne J Montgomery, Gillian R Lauder, Carl L von Baeyer
: There is inadequate age-specific data to support the use of current self-report pain scales in 3- and 4-year-old children. Most preschool-aged children also lack the necessary cognitive development to use standard scales. We aimed to evaluate the validity and feasibility of two novel simplified scales (Simplified Faces Pain Scale, S-FPS; Simplified Concrete Ordinal Scale, S-COS) for preschool-aged children. These simplified scales used a two-step self-report method: children were first asked whether they have pain (yes/no); only if yes, then pain intensity was self-reported using a 3-point scale with visual aids signifying mild/moderate/severe...
January 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28065813/aapt-diagnostic-criteria-for-chronic-sickle-cell-disease-pain
#17
REVIEW
Carlton Dampier, Tonya M Palermo, Deepika S Darbari, Kathryn Hassell, Wally Smith, William Zempsky
: Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high healthcare costs. While episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain experience of many older adolescents and adults. A common set of criteria for classifying chronic pain associated with SCD would enhance SCD pain research efforts in epidemiology, pain mechanisms, and clinical trials of pain management interventions, and ultimately improve clinical assessment and management...
January 5, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28063959/activity-pattern-profiles-relationship-with-affect-daily-functioning-impairment-and-variables-related-to-life-goals
#18
Rosa Esteve, Alicia E López-Martínez, Madelon L Peters, Elena R Serrano-Ibáñez, Gema T Ruíz-Párraga, Henar González-Gómez, Carmen Ramírez-Maestre
: The aim of this cross-sectional study was to identify subgroups of patients on the basis of their activity patterns and to investigate their relationship with life goals, optimism, affect, and functioning. The sample was comprised of 276 patients with chronic musculoskeletal pain. Hierarchical cluster analysis was performed on the activity pattern variables and the resulting clusters were compared using 1-way analysis of variance. The 4-cluster was the optimal solution. The 4 clusters comprised: 1) avoiders: patients with high levels of avoidance and low levels of persistence, who use pacing to reduce pain, 2) doers: patients with high levels of persistence and low levels of pacing and avoidance, 3) extreme cyclers: patients with high levels of avoidance and persistence and low levels of pacing, and 4) medium cyclers: patients with moderately high levels of avoidance and persistence and high levels of pacing...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28063958/prevention-of-chronic-post-thoracotomy-pain-in-rats-by-intrathecal-resolvin-d1-and-d2-effectiveness-of-perioperative-and-delayed-drug-delivery
#19
Jeffery Chi-Fei Wang, Gary R Strichartz
: Thoracotomy results in a high frequency of chronic post-operative pain. Resolvins are endogenous molecules, synthesized and released by activated immune cells, effective against inflammatory and neuropathic pain. Different resolvins have differential actions on selective neuronal and glial receptors and enzymes. This paper examines the ability of intrathecal Resolvin D1 (RvD1) and Resolvin D2 (RvD2) to reduce chronic post-thoracotomy pain in rats. Thoracotomy, involving intercostal incision and rib retraction, resulted in a decrease in the mechanical force threshold to induce nocifensive behavior, an enlargement of the pain-sensitive area, and an increase in the fraction of rats showing nocifensive behavior, all for at least 5 weeks...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28063957/initial-development-and-validation-of-a-patient-reported-symptom-survey-for-small-fiber-polyneuropathy
#20
Roi Treister, Mette Lodahl, Magdalena Lang, Shelley S Tworoger, Shlomo Sawilowsky, Anne Louise Oaklander
: Small-fiber polyneuropathy (SFPN) affects unmyelinated and thinly myelinated peripheral axons. Several questionnaires have been developed to assess polyneuropathy from diabetes or chemotherapy, but none for SFPN from other or unknown causes. A comprehensive survey could help clinicians diagnose and assess treatment responses, define prevalence natural history and cures, and identify research subjects. Thus, we developed the 1-page Small-Fiber Symptom Survey, using input from patients and 21 medical/scientific experts...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
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