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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/29155166/do-correlates-of-pain-related-stoicism-and-cautiousness-differ-in-younger-and-older-people-with-advanced-cancer
#1
Kenneth Mah, Kim T Tran, Lynn R Gauthier, Gary Rodin, Camilla Zimmermann, David Warr, S Lawrence Librach, Malcolm Moore, Frances A Shepherd, Lucia Gagliese
Age differences are not evident in pain-related stoicism and cautiousness in people with cancer pain. Little is known about the factors associated with these pain-related attitudes or age-related patterns in these associations. The present cross-sectional study investigated the biopsychosocial correlates of the attitudes in younger and older patients with advanced cancer. Pain-related stoicism (fortitude, concealment, superiority) and cautiousness (self-doubt, reluctance) were assessed using the Pain Attitudes Questionnaire-Revised (PAQ-R)...
November 16, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29155209/altered-primary-motor-cortex-structure-organisation-and-function-in-chronic-pain-a-systematic-review-and-meta-analysis
#2
REVIEW
Wei-Ju Chang, Neil E O'Connell, Paula R Beckenkamp, Ghufran Alhassani, Matthew B Liston, Siobhan M Schabrun
Chronic pain can be associated with movement abnormalities. The primary motor cortex (M1) has an essential role in the formulation and execution of movement. A number of changes in M1 function have been reported in studies of people with chronic pain. This review systematically evaluated the evidence for altered M1 structure, organisation and function in people with chronic pain of neuropathic and non-neuropathic origin. Database searches were conducted and a modified STROBE checklist was used to assess the methodological quality of included studies...
November 15, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29155208/inflammatory-renin-angiotensin-system-disruption-attenuates-sensory-hyperinnervation-and-mechanical-hypersensitivity-in-a-rat-model-of-provoked-vestibulodynia
#3
Anuradha Chakrabarty, Zhaohui Liao, Ying Mu, Peter G Smith
Vestibulodynia is characterized by peri-vaginal mechanical hypersensitivity, hyperinnervation, and abundant inflammatory cells expressing renin-angiotensin system proteins. We developed a tractable rat model of vestibulodynia to further assess the contributions of the renin-angiotensin system. Complete Freund's adjuvant (CFA) injected into the posterior vestibule induced marked vestibular hypersensitivity throughout a 7-day test period. Numbers of axons immunoreactive for PGP9.5, calcitonin gene-related peptide, and GFRα2 were increased...
November 15, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29154919/patient-reported-outcomes-and-opioid-use-by-outpatient-cancer-patients
#4
N Moryl, V Dave, P Glare, A Bokhari, V T Malhotra, A Gulati, J Hung, V Puttanniah, Y Griffo, R Tickoo, A Wiesenthal, S D Horn, C E Inturrisi
The Memorial Sloan-Kettering Pain Registry contains patient characteristics, treatments, and outcomes for a prospective cohort of 1534 chronic pain cancer patients who were seen at outpatient pain service clinics. Average pain intensity (Brief Pain Inventory) was reported as mild by 24.6% of patients, moderate by 41.5%, and severe by 33.9%. The patient's report of average percent pain relief and health state (EQ-5D) was inversely related to average pain intensity category, while measures of pain interference, number of worst pain locations, and physical and psychological distress were directly related to pain intensity category...
November 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29154918/attentional-modulation-of-somatosensory-processing-during-the-anticipation-of-movements-accompanying-pain-an-event-related-potential-study
#5
A Clauwaert, D M Torta, L Danneels, S Van Damme
Attending to pain-relevant information is crucial to protect us from physical harm. Behavioral studies have already suggested that during anticipation of pain somatosensory input at the body location under threat is prioritized. However, research using daily life cues for pain, especially movements, is lacking. Furthermore, no studies have looked at cortical processing associated with somatosensory processing during threatened movements. The current study aims to investigate whether movements accompanying pain automatically steer attention towards somatosensory input at the threatened location, affecting somatosensory evoked potentials...
November 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29122652/how-can-we-best-reduce-pain-catastrophizing-in-adults-with-chronic-non-cancer-pain-a-systematic-review-and-meta-analysis
#6
REVIEW
Robert Schütze, Clare Rees, Anne Smith, Helen Slater, Jared M Campbell, Peter O'Sullivan
Pain catastrophizing (PC), defined as an exaggerated negative cognitive-affective orientation toward pain, is one of the strongest psychological predictors of pain outcomes. While regularly included as a process variable in clinical trials, there have been no comprehensive reviews of how it can be modified. Using a registered protocol (PROSPERO 2016 CRD42016042761), we searched MEDLINE, PsychINFO, EMBASE, CINAHL, and CENTRAL up to November 2016 for all randomized controlled trials measuring PC in adults with chronic non-cancer pain...
November 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29102693/children-with-chronic-pain-response-trajectories-following-intensive-pain-rehabilitation-treatment
#7
Laura E Simons, Christine B Sieberg, Caitlin Conroy, Edin T Randall, Julie Shulman, David Borsook, Charles Berde, Navil F Sethna, Deirdre E Logan
Intensive pain rehabilitation programs for children with chronic pain are effective for many patients. However, characteristics associated with treatment response have not been well documented. Here we report trajectories of pain and functional impairment in patients with chronic pain up to one year after intensive pain rehabilitation and examine baseline factors associated with treatment response. Patients (n=253) with chronic pain and functional disability were assessed at 5 time points (admission, discharge, 1-month, 4-month, and 12-month follow-up)...
November 1, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29081370/unravelling-the-relationship-between-parent-and-child-ptsd-and-pediatric-chronic-pain-the-mediating-role-of-pain-catastrophizing
#8
Alexandra Neville, Sabine Soltani, Maria Pavlova, Melanie Noel
Clinically elevated rates of posttraumatic stress disorder (PTSD) symptoms are found among many youth with chronic pain and their parents and are linked to worse child pain outcomes. Conceptual models of mutual maintenance in pediatric PTSD and chronic pain posit that child and parent pain catastrophizing are key mechanisms underlying this co-occurrence. The current study was the first to examine child and parent pain catastrophizing as potential mediators in the child PTSD-child pain and parent PTSD-child pain relationships among a cohort of youth with chronic pain...
October 25, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29079542/aapt-diagnostic-criteria-for-chronic-abdominal-pelvic-and-urogenital-pain-irritable-bowel-syndrome
#9
QiQi Zhou, Ursula Wesselmann, Lynn Walker, Linda Lee, Lonnie Zeltzer, G Nicholas Verne
In conjuction with the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the US Food and Drug Administration and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative strove to develop the characteristics of a diagnostic system useful for clinical and research purposes across disciplines and types of chronic pain conditions. Following the establishment of these characteristics, a working group of clinicians and clinical and basic scientists with expertise in abdominal, pelvic, and urogenital pain began generating core diagnostic criteria and defining the related extraintestinal somatic pain and other symptoms experienced by patients...
October 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29079541/withdrawn-sex-specific-effects-of-gender-identification-on-pain-study-recruitment
#10
L Mattos Feijó, G Z Tarman, C Fontaine, R Harrison, T Johnstone, T V Salomons
No abstract text is available yet for this article.
October 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29079540/il-18-contributes-to-bone-cancer-pain-by-regulating-glia-cells-and-neuron-interaction
#11
Su Liu, Yue-Peng Liu, You Lv, Jun-Li Yao, Dong-Mei Yue, Mao-Yin Zhang, Dun-Yi Qi, Gong-Jian Liu
BACKGROUND: Glia cells hyperactivity has been proposed to be responsible for chronic pain, however, the mechanisms remain unclear. IL-18, released from glial cells, has been reported to be involved in neuropathic pain. Here, we investigated the role of IL-18 in bone cancer pain. METHODS: Bone cancer pain was mimicked by injecting Walker-256 mammary gland carcinoma cells into the intramedullary space of the tibia in rats. Expression and location of IL-18 and IL-18 receptor were tested...
October 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29054493/association-of-prescription-drug-monitoring-program-use-with-opioid-prescribing-and-health-outcomes-a-comparison-of-program-users-and-non-users
#12
Richard A Deyo, Sara E Hallvik, Christi Hildebran, Miguel Marino, Rachel Springer, Jessica M Irvine, Nicole O'Kane, Joshua Van Otterloo, Dagan A Wright, Gillian Leichtling, Lisa M Millet, Jody Carson, Wayne Wakeland, Dennis McCarty
Prescription drug monitoring programs (PDMPs) are a response to the prescription opioid epidemic, but their impacts on prescribing and health outcomes remain unclear, with conflicting reports. We sought to determine if prescriber use of Oregon's prescription drug monitoring program (PDMP) led to fewer high-risk opioid prescriptions or overdose events. We conducted a retrospective cohort study from October, 2011 through October, 2014, using statewide PDMP data, hospitalization registry, and vital records. Early PDMP registrants (n=927) were matched with clinicians who never registered during the study period, using baseline prescribing metrics in a propensity score...
October 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29054492/a-cost-analysis-of-an-interdisciplinary-pediatric-chronic-pain-clinic
#13
Nicole E Mahrer, Jeffrey I Gold, Michael Luu, Patricia Herman
Chronic pain is characterized by high rates of functional impairment, healthcare utilization, and associated costs. Research supports the use of comprehensive, interdisciplinary treatment approaches. However, many hospitals hesitate to offer this full range of services, especially to Medi-Cal/Medicaid patients whose services are reimbursed at low rates. This cost analysis examines the impact on hospital and insurance costs of patients' enrollment in an interdisciplinary pediatric pain clinic, which includes medication management, psychotherapy, biofeedback, acupuncture, and massage...
October 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29038061/structural-and-functional-brain-changes-at-early-and-late-stages-of-complex-regional-pain-syndrome
#14
Mahsa Shokouhi, Collin Clarke, Patricia Morley-Forster, Dwight E Moulin, Karen Davis, Keith St Lawrence
Brain plasticity is demonstrated in complex regional pain syndrome (CRPS), although it is unclear how it modulates at different stages of CRPS. The observation that symptoms can progress over time suggests that the pattern of brain changes might also evolve. We measured structural and functional changes as well as sensorimotor integration at early and late stages (ES and LS) of CRPS. Twelve ES patients, sixteen LS patients, and sixteen age- and sex-matched controls were recruited. Gray matter (GM) volume was estimated using voxel-based morphometry...
October 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29038060/comparing-pain-and-depressive-symptoms-of-chronic-opioid-therapy-patients-receiving-dose-reduction-and-risk-mitigation-initiatives-to-usual-care
#15
Manu Thakral, Rod L Walker, Kathleen Saunders, Susan M Shortreed, Michael Parchman, Ryan N Hansen, Evette Ludman, Karen J Sherman, Sascha Dublin, Michael Von Korff
Dose reduction and risk mitigation initiatives have been recommended to reduce opioid-related risks among patients receiving chronic opioid therapy (COT), but questions remain over whether these initiatives worsen pain control and quality of life. In 2014-15, we interviewed 1588 adult COT patients within a healthcare system in Washington State and compared those who received dose reduction and risk mitigation initiatives in primary care clinics (intervention) to patients in comparable healthcare settings without initiatives (control)...
October 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29031785/prior-mental-disorders-and-subsequent-onset-of-chronic-back-or-neck-pain-findings-from-19-countries
#16
Maria Carmen Viana, Carmen C W Lim, Flavia Garcia Pereira, Sergio Aguilar-Gaxiola, Jordi Alonso, Ronny Bruffaerts, Peter de Jonge, Jose Miguel Caldas-de-Almeida, Siobhan O'Neill, Dan J Stein, Ali Al-Hamzawi, Corina Benjet, Graça Cardoso, Silvia Florescu, Giovanni de Girolamo, Josep Maria Haro, Chiyi Hu, Viviane Kovess-Masfety, Daphna Levinson, Marina Piazza, José Posada-Villa, Daniel Rabczenko, Ronald C Kessler, Kate M Scott
Associations between depression/anxiety and pain are well established, but its directionality is not clear. We examined the associations between temporally prior mental disorders and subsequent self-reported chronic back/neck pain onset, and investigated the variation in the strength of associations by timing of events during the life course, and by gender. Data were from population-based household surveys conducted in 19 countries (n=52,095). Lifetime prevalence and age-of-onset of 16 DSM-IV mental disorders, and the occurrence and age-of-onset of back/neck pain were assessed using the Composite International Diagnostic Interview...
October 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29030323/gender-and-the-association-between-long-term-prescription-opioid-use-and-new-onset-depression
#17
Joanne Salas, Jeffrey F Scherrer, Brian K Ahmedani, Laurel A Copeland, Kathleen K Bucholz, Mark D Sullivan, Thomas Burroughs, F David Schneider, Patrick J Lustman
Women have a higher prevalence of chronic non-cancer pain conditions and report more severe pain, yet, it is not known if the association between long term opioid analgesic use (OAU) and risk of a new depression episode (NDE) differs by gender. We analyzed patient data from the Veterans Health Administration (VHA; 2000 to 2012; n=70,997) and a large private-sector health care organization (2003 to 2012; n=22,981) to determine whether long-term OAU and risk of NDE differed by gender. Patients were free of depression and OAU for two years prior to baseline...
October 10, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29030322/pain-affects-visual-orientation-an-eye-tracking-study
#18
K Schmidt, M Gamer, K Forkmann, U Bingel
Due to its unique evolutionary relevance, it is understood that pain automatically attracts attention. So far, such attentional bias has mainly been shown for pain-related stimuli whereas little is known about shifts in attentional focus following actual painful stimulation. This study investigated attentional shifts by assessing eye movements into the direction of painful stimulation. Healthy participants were presented either a blank screen or a picture showing a natural scene while painful electrical stimuli were applied to the left or right hand...
October 10, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28993265/the-concept-of-contexts-in-pain-generalization-of-contextual-pain-related-fear-within-a-de-novo-category-of-unique-contexts
#19
Ann Meulders, Marc Patrick Bennett
The experience of unpredictable pain fluctuations can trigger anticipatory pain-related fear. When discrete predictors for pain are lacking, fear typically accrues to the broader environmental context: a phenomenon referred to as contextual pain-related fear. We examined whether conceptual similarity between discrete contexts facilitates pain-related fear generalization; this mechanism is known as category-level fear generalization. Using a voluntary joystick movement paradigm, pain-free participants performed movements in two contexts (within-subjects design); context was manipulated by varying background color screens...
October 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28962895/sleep-mediates-the-association-between-ptsd-symptoms-and-chronic-pain-in-youth
#20
Melanie Noel, Jillian Vinall, Lianne Tomfohr-Madsen, Amy Lewandowski Holley, Anna C Wilson, Tonya M Palermo
Symptoms of post-traumatic stress disorder (PTSS) and chronic pain have been shown to co-occur at high rates in adolescents and this co-occurrence is linked to worse pain and quality of life. Sleep disturbance has been posited as a mechanism underlying this co-occurrence in conceptual models of mutual maintenance. This study examined the mediating role of sleep in the relationship between PTSS and pain in youth (aged 10-17 years) with chronic pain. Ninety-seven participants completed measures of PTSS, pain (intensity and interference), anxiety symptoms, and sleep quality, in addition to demographics...
September 26, 2017: Journal of Pain: Official Journal of the American Pain Society
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