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Journal of Pain: Official Journal of the American Pain Society

Barry L Whitsel, Charles J Vierck, Robert S Waters, Mark Tommerdahl, Oleg V Favorov
Traditionally, cytoarchitectonic area 3a of primary somatosensory cortex (SI) has been regarded as a proprioreceptive relay to motor cortex. However, neuronal spike train recordings and optical intrinsic signal imaging, obtained from nonhuman sensorimotor cortex, show that neuronal activity in some of cortical columns in area 3a can be readily triggered by C-nociceptor afferent drive. These findings indicate that area 3a is a critical link in cerebral cortical encoding of 2nd /slow pain. Also, area 3a contributes to abnormal pain processing in the presence of activity-dependent reversal of GABAA receptor-mediated inhibition...
September 15, 2018: Journal of Pain: Official Journal of the American Pain Society
Audrey P Wang, Annie A Butler, John D Valentine, Caroline D Rae, James McAuley, Simon C Gandevia, G Lorimer Moseley
Complex regional pain syndrome (CRPS) is associated with deficits in sensorimotor control. Here we used a novel finger illusion to investigate whether CRPS is associated with reduced weighting of bimanual hand representations. The illusion normally induces a compelling feeling that the hands are close together when in fact they are 12cm apart. People with CRPS and age, gender and dominant hand-matched controls tested the illusion in the midline then on either side of the midline. The illusion had two variants; the passive pincer-grip position, without contact ('No Grasp'), and with contact ('Grasp'), of the artificial finger...
September 13, 2018: Journal of Pain: Official Journal of the American Pain Society
Marina R Connolly, Jenna Y Chaudari, Ximeng Yang, Nam Ward, Rachel A Kitt, Rachel S Herrmann, Elliot J Krane, Alyssa A LeBel, Shannon M Smith, Gary A Walco, Steven J Weisman, Dennis C Turk, Robert H Dworkin, Jennifer S Gewandter
Fewer randomized clinical trials (RCTs) are conducted for chronic or recurrent pain in pediatric populations compared with adult populations; thus data to support treatment efficacy in children are limited. This article evaluates design features and reporting practices of RCTs for chronic and recurrent pain that are likely unique to, or particularly important in a pediatric population in order to promote improvements in the evidence base for pediatric pain treatments. Areas covered include outcome measure selection and reporting and reporting of adverse events (AEs) and challenges to recruitment and retention...
September 13, 2018: Journal of Pain: Official Journal of the American Pain Society
Caroline E Hinkle, Raimi L Quiton
Optimism is associated with lower pain sensitivity, positive adjustment to chronic pain, and greater reduction of pain thresholds in a conditioned pain modulation (CPM) paradigm. We hypothesized that participants with higher levels of optimism would experience greater inhibition of suprathreshold pain during CPM. Seventy-seven healthy adults completed a test of optimism, the Life Orientation Test-Revised (LOT-R), as well as measures of depression, pain catastrophizing, and neuroticism. Participants also underwent psychophysical tests of heat pain tolerance, heat pain threshold, and CPM...
September 13, 2018: Journal of Pain: Official Journal of the American Pain Society
Michael Von Korff, Kathleen Saunders, Sascha Dublin, Rod L Walker, Manu Thakral, Karen J Sherman, Evette J Ludman, Ryan N Hansen, Michael Parchman, Susan M Shortreed
We assessed effects of opioid dose and risk reduction initiatives on opioid overdose rates among chronic opioid therapy (COT) patients. Using an interrupted time series design, we compared trends in overdose rates. We compared COT patients in settings that implemented a COT dose reduction initiative and then a COT risk stratification/monitoring initiative to similar COT patients from control settings. From 2006-14, 31,142 COT patients (22,673 intervention, 8,469 control) experienced 311 fatal or non-fatal opioid overdoses...
September 3, 2018: Journal of Pain: Official Journal of the American Pain Society
Zina Trost, John Sturgeon, Adam Guck, Maisa Ziadni, Liza Nowlin, Burel Goodin, Whitney Scott
Injustice perception has emerged as a risk factor for problematic musculoskeletal pain outcomes. Despite the prevalence and impact of chronic low back pain (CLBP) no study has addressed injustice appraisals specifically among individuals with CLBP. In addition, despite racial/ethnic disparities in pain, existing injustice research has relied almost exclusively on White/Caucasian participant samples. The current study examined associations between perceived injustice and pain, disability, and depression in a diverse community sample of individuals with CLBP (N=137) - 51(37...
September 1, 2018: Journal of Pain: Official Journal of the American Pain Society
Pradeep Suri, Kelly Stolzmann, Rhonda Williams, Terri K Pogoda
Traumatic brain injury (TBI) may be a predisposing factor to pain syndromes other than headache. We conducted a longitudinal cohort study among Veterans evaluated for TBI in the Department of Veterans Affairs (VA). Among 36,880 Veterans at baseline, 55% reported back pain. TBI history was classified by trained clinicians according to VA-Department of Defense criteria. 14,223 Veterans without back pain were followed for up to 6 years for new (incident) episodes of VA care for back pain. We estimated adjusted odds ratios (aORs), adjusted hazard ratios (aHRs) and 95% confidence intervals (CI), accounting for covariates...
August 30, 2018: Journal of Pain: Official Journal of the American Pain Society
Keith G Wilson, Dyana Castillo, John Kowal, An Gie Yong, Lachlan A McWilliams
Limitations in physical function and participation are important domains of assessment in chronic pain. In 1995, the International Association for the Study of Pain distributed a self-report measure of functional limitations. Although the questionnaire has been used in research studies, it has never been subjected to a thorough investigation of its measurement properties. In this study, 941 patients with chronic pain completed the 16-item Limitations in Daily Activities Scale (LIDAS) at two pre-treatment and one post-treatment assessment points...
August 30, 2018: Journal of Pain: Official Journal of the American Pain Society
Barbara J Turner, Yuanyuan Liang, Natalia Rodriguez, Raudel Bobadilla, Maureen J Simmonds, Zenong Yin
Based on input of rural, largely Hispanic persons with chronic pain, a low-literacy, 6-month self-management program was developed, drawing on elements of existing pain toolkits. In a randomized trial, low-income, primarily Hispanic patients with chronic pain received the program in 6 sessions of 1-on-1 meetings with a trained health educator in clinic or in 8 group lectures by experts in the community. Intention-to-treat analyses in linear mixed-effects models were conducted for 5 secondary outcomes at 6 months, including Brief Pain Inventory pain severity and interference, Patient Health Questionnaire-9, 12-Item Short-Form Survey Mental Component Summary, and Tampa Scale for Kinesiophobia-11...
August 24, 2018: Journal of Pain: Official Journal of the American Pain Society
Gustavo Plaza-Manzano, Marta Ríos-León, Patricia Martín-Casas, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas, Ricardo Ortega-Santiago
Our aim was to investigate the differences in pressure sensitivity over musculoskeletal and nerve symptomatic and distant areas between individuals with plantar heel pain and healthy subjects and to determine the relationship between sensitivity to pressure pain, foot pain, and fascia thickness. Thirty-five patients with unilateral chronic plantar heel pain and 35 matched healthy controls participated. Pressure pain thresholds (PPTs) were assessed bilaterally over several nerve trunks (median, radial, ulnar, common peroneal, tibial, and sural nerve trunks) and musculoskeletal structures (calcaneus, medial gastrocnemius, tibialis anterior, and second metacarpal) by an assessor blinded to the subject's condition...
August 16, 2018: Journal of Pain: Official Journal of the American Pain Society
Chema Strik, Barend van den Beukel, Dagmar van Rijckevorsel, Martijn W J Stommel, Richard P G Ten Broek, Harry van Goor
The incidence of chronic postoperative abdominal pain (CPAP) after abdominal surgery is substantial and decreases overall quality of life. One in three patients report to have pain-related interference with mood, sleep and enjoyment of life and 12% visit the emergency department for pain related symptoms. Previous studies lack data on preoperative health and pain status, or are limited by small patient samples. The aim of this study is to assess risk factors for CPAP and gastrointestinal complaints six months after surgery...
August 11, 2018: Journal of Pain: Official Journal of the American Pain Society
Maria Hedman-Lagerlöf, Erik Hedman-Lagerlöf, Brjánn Ljótsson, Rikard K Wicksell, Ida Flink, Erik Andersson
Fibromyalgia (FM) is a prevalent and debilitating chronic pain disorder, associated with a substantial economic burden. Although there are several studies investigating the effectiveness of psychological treatments such as cognitive behavior therapy for FM, studies on cost-effectiveness are scarce. The aim of the present study was to investigate the cost-effectiveness of Internet-delivered exposure therapy (iExp) for FM. We used health economic data from a recently conducted randomized controlled trial, where 140 participants were randomized to either iExp or a waitlist control condition (WLC)...
August 11, 2018: Journal of Pain: Official Journal of the American Pain Society
Wen-Qiang Cui, Wen-Shan Sun, Fei Xu, Xue-Ming Hu, Wei Yang, Yang Zhou, Li-Xia Du, Wen-Wen Zhang, Qi-Liang Mao-Ying, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang
Acupoint catgut embedding (ACE) is a widely used traditional Chinese medicine method to manage various diseases, including chronic inflammatory pain. We sought to assess the possible analgesic effects of ACE in comparison to electroacupuncture (EA) and to study the analgesic mechanisms of ACE in a rat model of inflammatory pain induced by injection of complete Freund's adjuvant (CFA) into the hind paw of rats. The von Frey, radiant heat, and gait analysis tests were performed to evaluate the analgesic effects of ACE and EA, and western blot and immunohistochemistry assays were carried out to determine the molecular mechanisms of ACE...
August 10, 2018: Journal of Pain: Official Journal of the American Pain Society
Clémentine Brun, Nicolas Giorgi, Anne-Marie Pinard, Martin Gagné, Candida S McCabe, Catherine Mercier
Chronic pain is often accompanied by patient reported distorted body perception and an altered kinesthesia (referring to the senses of limb position and limb movement), but the association between these deficits is unknown. OBJECTIVES: 1- to assess body perception, and the senses of limb position and limb movement in Complex Regional Pain Syndrome (CRPS); 2- to test whether these variables are related to each other and to pain intensity. Thirteen upper limb CRPS (mean pain intensity: 4...
August 9, 2018: Journal of Pain: Official Journal of the American Pain Society
Alessandro Chiarotto, Lara J Maxwell, Raymond W Ostelo, Maarten Boers, Peter Tugwell, Caroline B Terwee
Visual Analogue Scale (VAS), Numeric Rating Scale (NRS), and Pain Severity subscale of the Brief Pain Inventory (BPI-PS)] are the most frequently used instruments to measure pain intensity in low back pain (LBP). However, their measurement properties in this population have not been systematically reviewed. The goal of this study was to provide such systematic evidence synthesis. Six electronic sources (MEDLINE, EMBASE, CINAHL, PsycINFO, SportDiscus, Google Scholar) were searched (July 2017). Studies assessing any measurement property in patients with non-specific LBP were included...
August 9, 2018: Journal of Pain: Official Journal of the American Pain Society
Blake F Dear, Milena Gandy, Eyal Karin, Rhiannon Fogliati, Vincent J Fogliati, Lauren G Staples, Bethany M Wootton, Louise Sharpe, Nickolai Titov
Little is known about the long-term outcomes of emerging Internet-delivered pain management programs. The current study reports the 12- and 24-month follow-up data from a randomized controlled trial (n = 490) of an Internet-delivered pain management program, the Pain Course. The initial results of the trial to the 3-month follow-up have been reported elsewhere. There were significant improvements in disability, depression, anxiety, and pain levels across 3 treatment groups receiving different levels of clinician support compared with a treatment as the usual control...
August 9, 2018: Journal of Pain: Official Journal of the American Pain Society
Cornelius B Groenewald, Emily F Law, Emma Fisher, Sarah E Beals-Erickson, Tonya M Palermo
Prescription opioid misuse is a serious public health concern, yet antecedent factors are poorly described. Using data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) (n = 14,784), we examined the longitudinal relationship between history of adolescent chronic pain and odds of misusing prescription opioids in adulthood. The primary predictor variable was chronic pain status during adolescence. The primary outcome variables were prescription opioid misuse during early adulthood and adulthood...
August 8, 2018: Journal of Pain: Official Journal of the American Pain Society
John D Breckenridge, Karen A Ginn, Sarah B Wallwork, James H McAuley
The left/right judgement task (LRJT) is the most commonly used method of assessing motor imagery performance. Abnormally long response times are thought to reflect delayed processing of body/spatial representations and poor accuracy is thought to reflect disrupted cortical proprioceptive representations or body schema. Slower and less accurate responses on the LRJT have been reported in a variety of chronic musculoskeletal pain conditions. To date no systematic review of the literature has been conducted to assess if altered motor imagery performance as measured by the LRJT is characteristic of all chronic musculoskeletal pain conditions...
August 8, 2018: Journal of Pain: Official Journal of the American Pain Society
Mark H Pitcher, Michael Von Korff, M Catherine Bushnell, Linda Porter
The multidimensional nature of chronic pain is not reflected by definitions based solely on pain duration, resulting in high prevalence estimates limiting effective policy development. The newly proposed concept of high-impact chronic pain (HICP) incorporates both disability and pain duration to identify a more severely impacted portion of the chronic pain population yet remains uncharacterized at the population level. As such, we used the 2011 National Health Interview Survey (N = 15,670) to 1) assess the likelihood of disability in the overall chronic pain population, 2) estimate the prevalence of HICP, and 3) characterize the disability, health status, and health care use profile of this population in the United States...
August 7, 2018: Journal of Pain: Official Journal of the American Pain Society
Eva Widerström-Noga, Kim D Anderson, Salomé Perez, Alberto Martinez-Arizala, Jessica M Cambridge
The present study was part of a larger mixed-methods study concerning facilitators and barriers to living with chronic pain after spinal cord injury. The agreement with themes obtained in qualitative interviews were quantified in a large online survey and overarching themes were defined by factor analysis. The present study aimed to define subgroups based on cluster analysis of the overarching themes' factor scores and to compare the subgroups on pain-related variables. Three subgroups-high pain impact, moderate pain impact, and low pain impact-emerged...
July 27, 2018: Journal of Pain: Official Journal of the American Pain Society
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