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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/28088507/patient-reported-outcomes-and-opioid-use-in-outpatients-with-chronic-pain
#1
Lisa R Witkin, David Zylberger, Neel Mehta, Madeleine Hindenlang, Christopher Johnson, Jacob Kean, Susan D Horn, Charles E Inturrisi
: The Weill Cornell Medical College (WCMC) Pain Registry database contains patient characteristics, treatments, and outcomes for a prospective cohort of 1159 chronic pain patients who were seen at the WCMC Pain Medicine outpatient clinic from 7/08/2011 to 12/10/2014. Patients aged 45-64 comprised 43% followed by age >=65 at 37%. Fifty-eight percent were female. Average pain intensity (Brief Pain Inventory) was reported as mild by 22.3% of patients, moderate by 34.7%, and severe by 43...
January 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28088506/linguistic-indicators-of-pain-catastrophizing-in-patients-with-chronic-musculoskeletal-pain
#2
Doerte U Junghaenel, Stefan Schneider, Joan E Broderick
: The present study examined markers of pain catastrophizing in the word use of patients with chronic pain. Patients (n = 71) completed the Pain Catastrophizing Scale and wrote about their life with pain. Quantitative word count analysis examined whether the essays contained linguistic indicators of catastrophizing. Bivariate correlations showed that catastrophizing was associated with greater use of first person singular pronouns, such as "I" (r = .27, p≤ .05) and pronouns referencing other people (r = 28, p≤ ...
January 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28088505/gaps-in-the-public-s-knowledge-about-chronic-pain-representative-sample-of-hispanic-residents-from-five-states
#3
Barbara J Turner, Yuanyuan Liang, Natalia Rodriguez, Melissa A Valerio, Andrea Rochat, Jennifer S Potter, Paula Winkler
: Educating the general public about chronic pain and its care is a national health priority. We evaluated knowledge, attitudes, and beliefs (KAB) of a five-state, population-based sample of Hispanics aged 35-75 without chronic pain, representing over 8.8 million persons. A web-based survey assessed KAB using an adapted version of the Survey of Pain Attitudes-Brief and self-reported knowledge about chronic pain (nothing, a little, a lot). In unweighted analyses of participants (n=346), mean age was 52...
January 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28089711/regulation-of-expression-of-hyperalgesic-priming-by-estrogen-receptor-alpha-in-the-rat
#4
Luiz F Ferrari, Dionéia Araldi, Jon D Levine
: Hyperalgesic priming, a sexually dimorphic model of transition to chronic pain, is expressed as prolongation of prostaglandin E2 (PGE2)-induced hyperalgesia by the activation of an additional pathway including an autocrine mechanism at the plasma membrane. The autocrine mechanism involves the transport of cAMP to the extracellular space, and its conversion to AMP and adenosine, by ecto-5'phosphodiesterase and ecto-5'nucleotidase, respectively. The end product, adenosine, activates A1 receptors, producing delayed onset prolongation of PGE2 hyperalgesia...
January 9, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28069521/validity-of-simplified-versus-standard-self-report-measures-of-pain-intensity-in-preschool-aged-children-undergoing-venipuncture
#5
Anthony Emmott, Nicholas West, Guohai Zhou, Dustin Dunsmuir, Carolyne J Montgomery, Gillian R Lauder, Carl L von Baeyer
: There is inadequate age-specific data to support the use of current self-report pain scales in 3- and 4-year-old children. Most preschool-aged children also lack the necessary cognitive development to use standard scales. We aimed to evaluate the validity and feasibility of two novel simplified scales (Simplified Faces Pain Scale, S-FPS; Simplified Concrete Ordinal Scale, S-COS) for preschool-aged children. These simplified scales used a two-step self-report method: children were first asked whether they have pain (yes/no); only if yes, then pain intensity was self-reported using a 3-point scale with visual aids signifying mild/moderate/severe...
January 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28065813/aapt-diagnostic-criteria-for-chronic-sickle-cell-disease-pain
#6
REVIEW
Carlton Dampier, Tonya M Palermo, Deepika S Darbari, Kathryn Hassell, Wally Smith, William Zempsky
: Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high healthcare costs. While episodic acute pain is the hallmark of this disorder, there is an increasing awareness that chronic pain is part of the pain experience of many older adolescents and adults. A common set of criteria for classifying chronic pain associated with SCD would enhance SCD pain research efforts in epidemiology, pain mechanisms, and clinical trials of pain management interventions, and ultimately improve clinical assessment and management...
January 5, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28063959/activity-pattern-profiles-relationship-with-affect-daily-functioning-impairment-and-variables-related-to-life-goals
#7
Rosa Esteve, Alicia E López-Martínez, Madelon L Peters, Elena R Serrano-Ibáñez, Gema T Ruíz-Párraga, Henar González-Gómez, Carmen Ramírez-Maestre
: The aim of this cross-sectional study was to identify subgroups of patients based on their activity patterns and to investigate their relationship with life goals, optimism, affect, and functioning. The sample comprised 276 patients with chronic musculoskeletal pain. Hierarchical cluster analysis was performed on the activity pattern variables and the resulting clusters were compared using 1-way ANOVA. The 4-cluster was the optimal solution. The four clusters comprised: a) Avoiders: patients with high levels of avoidance and low levels of persistence, who use pacing to reduce pain; b) Doers: patients with high levels of persistence and low levels of pacing and avoidance; c) Extreme Cyclers: patients with high levels of avoidance and persistence and low levels of pacing; and d) Medium Cyclers: patients with moderately high levels of avoidance and persistence and high levels of pacing...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28063958/prevention-of-chronic-post-thoracotomy-pain-in-rats-by-intrathecal-resolvin-d1-and-d2-effectiveness-of-perioperative-and-delayed-drug-delivery
#8
Jeffery Chi-Fei Wang, Gary R Strichartz
: Thoracotomy results in a high frequency of chronic post-operative pain. Resolvins are endogenous molecules, synthesized and released by activated immune cells, effective against inflammatory and neuropathic pain. Different resolvins have differential actions on selective neuronal and glial receptors and enzymes. This paper examines the ability of intrathecal Resolvin D1 (RvD1) and Resolvin D2 (RvD2) to reduce chronic post-thoracotomy pain in rats. Thoracotomy, involving intercostal incision and rib retraction, resulted in a decrease in the mechanical force threshold to induce nocifensive behavior, an enlargement of the pain-sensitive area, and an increase in the fraction of rats showing nocifensive behavior, all for at least 5 weeks...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28063957/initial-development-and-validation-of-a-patient-reported-symptom-survey-for-small-fiber-polyneuropathy
#9
Roi Treister, Mette Lodahl, Magdalena Lang, Shelley S Tworoger, Shlomo Sawilowsky, Anne Louise Oaklander
: Small-fiber polyneuropathy SFPN affects unmyelinated and thinly myelinated peripheral axons. Several questionnaires have been developed to assess polyneuropathy from diabeties or chemotherapy, but none for SFPN from other or unknown causes. A comprehensive survey could help clinicians diagnose and assess treatment responses, define prevalence natural history and cures, and identify research subjects. Thus, we developed the one-page Small-fiber Symptom Survey (SSS), using input from patients and 21 medical/scientific experts...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28062311/trpa1-and-trpv1-antagonists-do-not-inhibit-human-acidosis-induced-pain
#10
Matthias G Schwarz, Barbara Namer, Peter W Reeh, Michael J M Fischer
: Acidosis occurs in a variety of pathophysiological and painful conditions where it is thought to excite or contribute to excitation of nociceptive neurons. Despite potential clinical relevance the principal receptor for sensing acidosis is unclear, but several receptors have been proposed. We investigated the contribution of the acid sensing ion channels, TRPV1 and TRPA1 to peripheral pain signaling. We first established a human pain model using intra-epidermal injection of TRPA1 agonist carvacrol...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28062310/experiencing-pain-in-the-presence-of-others-a-structured-experimental-investigation-of-older-adults
#11
Natasha L Gallant, Thomas Hadjistavropoulos
: The role of various forms of social support (including the mere presence of another person) in pain has been studied in children and younger adults, but parallel studies involving older persons have not been conducted. In this investigation, older adults (N =100) took part in a series of experimental pain tasks in each of the following conditions: alone, in the presence of a stranger, and in the presence of a family member. Indices of pain (threshold, tolerance, intensity, unpleasantness, facial expressions) and facial expressions of emotion were analyzed...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28062309/a-local-inflammatory-renin-angiotensin-system-drives-sensory-axon-sprouting-in-provoked-vestibulodynia
#12
Zhaohui Liao, Anuradha Chakrabarty, Ying Mu, Aritra Bhattacherjee, Martha Goestch, Catherine M Leclair, Peter G Smith
: Vestibulodynia is a form of provoked vulvodynia characterized by profound tenderness, hyperinnervation, and frequently inflammation within well-defined areas of the human vestibule. Prior experiments in animal models show that inflammatory hypersensitivity and hyperinnervation occur in concert with establishment of a local renin-angiotensin system (RAS). Moreover, mechanical hypersensitivity and sensory axon sprouting are prevented by blocking effects of angiotensin II on AT2 receptors...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28062308/spinal-reorganization-after-bone-fracture-in-mice
#13
Silke Hirsch, Alaa Ibrahim, Laura Krämer, Fabiola Escolano-Lozano, Tanja Schlereth, Frank Birklein
: Bone fracture with subsequent immobilization of the injured limb can cause Complex Regional Pain Syndrome (CRPS) in humans. Mechanisms of CRPS are still not completely understood but bone fracture with casting in mice leads to a similar posttraumatic inflammation as seen in humans and might therefore be an analogue to human CRPS. Here we report behavioral and spinal electrophysiological changes in mice that developed swelling of the paw, warming of the skin and pain in the injured limb after bone fracture...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28039101/increasing-optimism-protects-against-pain-induced-impairments-in-task-shifting-performance
#14
Jantine J L M Boselie, Linda M G Vancleef, Madelon L Peters
: Persistent pain can lead to difficulties in executive task performance. Three core executive functions that are often postulated are inhibition, updating and shifting. Optimism, the tendency to expect that good things happen in the future, has been shown to protect against pain-induced performance deterioration in the executive function updating. This study tested whether this protective effect of a temporary optimistic state by means of a writing and visualization exercise extended to the executive function shifting...
December 27, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28034828/evidenced-based-guidelines-on-the-treatment-of-fibromyalgia-patients-are-they-consistent-and-if-not-why-not-have-effective-psychological-treatments-been-overlooked
#15
Kati Thieme, Marc Mathys, Dennis C Turk
: We compared the recommendations and methodology of several recent evidence-based guidelines for the management of patients with fibromyalgia (FM) published by professional organizations: 1. American Pain Society (APS) (2005) 2. Association of the Scientific Medical Societies in Germany (AWMF) (2012) 3. Canadian Pain Society (CPS, 2013), - Also used in United Kingdom and 4. European League Against Rheumatism (EULAR) (2016) Each guideline used systematic reviews and meta-analyses as highest level of evidence, APS, CPS, and AWMF also included individual randomized clinical trials (RCT)...
December 26, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28007591/the-effectiveness-of-treatments-for-patients-with-medication-overuse-headache-a-systematic-review-and-meta-analysis
#16
REVIEW
Maaike J de Goffau, Andre R E Klaver, Marjolein G Willemsen, Patrick J E Bindels, Arianne P Verhagen
Worldwide, about 1-2% of the adult population suffers from chronic headache due to overuse of pain medication. Guidelines recommend acute withdrawal of medication, but the optimal treatment remains unknown. We aim to evaluate the benefit of treatments for patients with medication overuse headache (MOH). We performed an extensive literature search until November 2015, selecting randomized controlled trials that evaluated interventions for adults with MOH. Two authors assessed the eligible trials and extracted data...
December 19, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27993559/causal-mediation-in-the-development-of-painful-temporomandibular-disorder
#17
Anne E Sanders, Aderonke A Akinkugbe, Roger B Fillingim, Richard Ohrbach, Joel D Greenspan, William Maixner, Eric Bair, Gary D Slade
: We explored causal mediation of sleep quality and perceived stress in development of painful temporomandibular disorder (TMD). Sleep quality and perceived stress were assessed at baseline and quarterly intervals thereafter in 2,737 initially-TMD-free adults in the OPPERA prospective cohort study. During follow-up, incident TMD cases were classified using Research Diagnostic Criteria. Mediation analysis was conducted using a weighted Cox proportional hazards regression model that estimated hazard ratios and 95% confidence limits (HR, 95% CL) of first-onset TMD...
December 16, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27993558/higher-prescription-opioid-dose-is-associated-with-worse-patient-reported-pain-outcomes-and-more-health-care-utilization
#18
Benjamin J Morasco, Bobbi Jo Yarborough, Ning X Smith, Steven K Dobscha, Richard A Deyo, Nancy A Perrin, Carla A Green
: Some prior research has examined pain-related variables based on prescription opioid dose, but data from studies involving patient-reported outcomes have been limited. This study examined the relationships between prescription opioid dose and self-reported pain intensity, function, quality of life, and mental health. Participants were recruited from two large integrated health systems, Kaiser Permanente Northwest (n=331) and VA Portland Health Care System (n=186). To be included, participants had to have musculoskeletal pain diagnoses and be receiving stable doses of long-term opioid therapy (LTOT)...
December 16, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27986591/spinal-d-serine-increases-pkc-dependent-glun1-phosphorylation-contributing-to-the-sigma-1-receptor-induced-development-of-mechanical-allodynia-in-a-mouse-model-of-neuropathic-pain
#19
Sheu-Ran Choi, Ji-Young Moon, Dae-Hyun Roh, Seo-Yeon Yoon, Soon-Gu Kwon, Hoon-Seong Choi, Suk-Yun Kang, Ho-Jae Han, Alvin J Beitz, Jang-Hern Lee
: We have recently demonstrated that spinal sigma-1 receptor (Sig-1R) activation facilitates nociception via an increase in phosphorylation of the NMDA receptor GluN1 subunit (pGluN1). The present study was designed to examine whether the Sig-1R-induced facilitative effect on NMDA-induced nociception is mediated by D-serine, and whether D-serine modulates spinal pGluN1 expression and the development of neuropathic pain following chronic constriction injury (CCI) of the sciatic nerve. Intrathecal administration of the D-serine degrading enzyme, DAAO attenuated the facilitation of NMDA-induced nociception induced by the Sig-1R agonist, PRE084...
December 13, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27965045/a-trial-based-economic-evaluation-comparing-spinal-cord-stimulation-with-best-medical-treatment-in-painful-diabetic-peripheral-neuropathy
#20
Rachel Slangen, Catharina G Faber, Nicolaas C Schaper, Elbert A Joosten, Robert T van Dongen, Alfons G Kessels, Maarten van Kleef, Carmen D Dirksen
: The objective was to perform an economic evaluation comparing spinal cord stimulation in combination with best medical treatment (SCS) with best medical treatment (BMT) in painful diabetic peripheral neuropathy (PDPN) patients. Alongside a prospective two-center randomized controlled trial, involving 36 PDPN patients with severe lower limb pain, not responding to conventional therapy, an economic evaluation was performed. Incremental cost-effectiveness ratios (ICERs) were based on 1) societal costs and quality-adjusted life years (QALYs) and 2) direct healthcare costs and the number of successfully treated patients, respectively, both with a time horizon of 12 months...
December 10, 2016: Journal of Pain: Official Journal of the American Pain Society
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