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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/29777954/parent-responses-to-child-pain-during-intensive-interdisciplinary-pain-treatment-and-1-year-follow-up-%C3%A2-%C3%A2-%C3%A2
#1
Melissa Pielech, Dustin P Wallace, Megan Fitzgerald, Cara M Hoffart
Targeting parents' responses to their child's pain during intensive interdisciplinary pain treatment (IIPT) could influence child functioning. This longitudinal, observational study investigated changes in these responses and concurrent relationships between parent responses and changes in levels of child functioning and pain. Parents of youth age 10-19 years (M=15, SD=1.98) participated in twice weekly, parent-only groups while their teens were enrolled in IIPT (mean length of treatment 3.93 weeks, SD=1.16)...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777953/ultrasound-guided-application-of-percutaneous-electrolysis-as-an-adjunct-to-exercise-and-manual-therapy-for-subacromial-pain-syndrome-a-randomized-clinical-trial
#2
Lorena de-Miguel-Valtierra, Jaime Salom-Moreno, César Fernández-de-Las-Peñas, Joshua A Cleland, José L Arias-Buría
This randomized clinical trial compared the effects of adding US-guided percutaneous electrolysis into a program consisting of manual therapy and exercise on pain, related-disability, function and pressure sensitivity in subacromial pain syndrome. Fifty patients with subacromial pain syndrome were randomized into manual therapy and exercise or percutaneous electrolysis group. All patients received the same manual therapy and exercise program, one session per week for 5 consecutive weeks. Patients assigned to the electrolysis group also received the application of percutaneous electrolysis at each session...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777952/the-opportunity-to-avoid-pain-may-paradoxically-increase-fear
#3
Christine M van Vliet, Ann Meulders, Linda M G Vancleef, Johan W S Vlaeyen
Fear-avoidance models propose that pain-related fear may spur avoidance behaviour leading to chronic pain disability. Pain-related fear elicits avoidance behaviour, which is typically aimed at reducing fear. We hypothesized that engaging in avoidance may (paradoxically) increase rather than decrease pain-related fear (i.e. bidirectionality hypothesis). In a between-subject design, participants (N=64) were randomly assigned to the avoidance group or the control group. Avoidance group participants were led to believe they could avoid full exposure to a painful heat stimulus by pressing the stop-button, while control group participants believed they were exposed to the full painful heat stimulus at all times...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777951/experimental-referred-pain-extends-towards-previously-injured-location-an-explorative-study
#4
Thorvaldur Skuli Palsson, Shellie A Boudreau, Hans Jørgen Krebs, Thomas Graven-Nielsen
Facilitated pain mechanisms have been demonstrated in musculoskeletal pain but it is unclear whether a recent painful injury leaves the pain system sensitized. Pain characteristics were assessed in individuals who recently recovered from ankle pain (recovered pain group; n=25) and sex-matched controls (n=25) in response to tonic-pressure pain and saline-induced pain applied at the shin muscle. Pain intensity and pain referral patterns were recorded bilaterally after the painful muscle stimulus. Pressure pain thresholds (PPTs) were measured at the lower legs and shoulder...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777950/acceptance-and-commitment-therapy-for-prevention-of-chronic-post-surgical-pain-and-opioid-use-in-at-risk-veterans-a-pilot-randomized-controlled-study
#5
Lilian Dindo, M Bridget Zimmerman, Katherine Hadlandsmyth, Barbara StMarie, Jennie Embree, James Marchman, Toni Tripp-Reimer, Barbara Rakel
High levels of pain, significant anxiety, and/or depressive symptoms prior to surgery put patients at elevated risk forchronic pain and prolonged opioid use following surgery. The purpose of this preliminary study was to assess the efficacy of a one-day Acceptance and Commitment Therapy (ACT) workshop in "at-risk" Veterans for the prevention of chronic pain and opioid use following orthopedic surgery. In a randomized controlled trial, 88 at-risk Veterans undergoing orthopedic surgery were assigned to Treatment as Usual (TAU; N =44) or TAU plus a 1-day ACT workshop (N = 44)...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29772271/pain-management-after-bone-reconstruction-surgery-using-an-analgesic-bone-cement-a-functional-non-invasive-in-vivo-study-using-gait-analysis
#6
Manon Dupleichs, Martial Masson, Olivier Gauthier, Maeva Dutilleul, Jean-Michel Bouler, Elise Verron, Pascal Janvier
Postoperative pain following bone reconstruction is a serious complication that could jeopardize the global success of a surgery. This pain must be controlled and minimized during the first 3-4 postoperative days to prevent it from becoming chronic. In this study, a critical-size bone defect was created at the femoral distal end of rats and filled by an injectable calcium phosphate cement (CPC) loaded or not with local anesthetics (bupivacaine or ropivacaine). A functional evaluation of the gait was performed using the CatWalk system to compare the postoperative pain relief enhanced by the different CPCs after such a bone filling surgery...
May 14, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29758357/pharmacopuncture-with-scolopendra-subspinipes-suppresses-mechanical-allodynia-in-oxaliplatin-induced-neuropathic-mice-and-potentiates-clonidine-induced-anti-allodynia-without-hypotension-or-motor-impairment
#7
Seo-Yeon Yoon, Jeong-Yun Lee, Dae-Hyun Roh, Seog Bae Oh
Chemotherapy-induced neuropathic pain is a common dose-limiting side effect of anticancer drugs but lacks an effective treatment strategy. Scolopendra subspinipes (SS) has been used in traditional medicine to treat chronic neuronal diseases. Moreover, pharmacopuncture with SS (SSP) produces potent analgesia in humans and experimental animals. In this study, we examined the effect of SSP into the ST36 acupoint on oxaliplatin-induced mechanical allodynia in mice. Acupoint treatment with SSP (0.5%/20 μL) significantly reduced mechanical allodynia produced by a single oxaliplatin injection (10 mg/kg, i...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29758356/the-influence-of-placebo-analgesia-manipulations-on-pain-report-the-nociceptive-flexion-reflex-and-autonomic-responses-to-pain
#8
Jamie L Rhudy, Yvette M Güereca, Bethany L Kuhn, Shreela Palit, Magne Arve Flaten
Expectations for pain relief and experience/conditioning are psychological factors that contribute to placebo analgesia, yet few studies have studied the physiological mechanisms underlying their effects. This study randomized 133 participants to 4 groups: an expectation only (E-only) group, a conditioning only (C-only) group, an expectation plus conditioning (E+C) group, and a natural history (NH) control group. Painful electric stimulations were delivered before and after an inert cream was applied to the site of stimulation...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29758355/alcohol-and-opioid-use-in-chronic-pain-a-cross-sectional-examination-of-differences-in-functioning-based-on-misuse-status
#9
Kevin E Vowles, Katie Witkiewitz, Melissa Pielech, Karlyn A Edwards, Mindy L McEntee, Robert W Bailey, Lena Bolling, Mark D Sullivan
Opioid misuse is regularly associated with disrupted functioning in those with chronic pain. Less work has examined whether alcohol misuse may also interfere with functioning. This study examined frequency of opioid and alcohol misuse in 131 individuals (61.1% female) prescribed opioids for the treatment of chronic pain. Participants completed an anonymous survey online, consisting of measures of pain, functioning, and opioid and alcohol misuse. Cut-scores were used to categorize individuals according to substance misuse status; individuals were categorized as follows: 35...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29751110/electroencephalographic-predictors-of-neuropathic-pain-in-subacute-spinal-cord-injury
#10
Aleksandra Vuckovic, Mohammed Jajrees, Mariel Purcell, Helen Berry, Matthew Fraser
It is widely believed that cortical changes are a consequence of long standing neuropathic pain (NP). In this paper we demonstrate that NP in people with subacute spinal cord injury (SCI) has characteristic electroencephalographic (EEG) markers which precede the onset of pain. EEG was recorded in a relaxed state and during motor imagination tasks in 10 able bodied participants and 31 subacute SCI participants (11 with NP, 10 without NP and 10 who developed pain within 6 months of EEG recording). All 20 SCI participants initially without NP were tested for mechanically induced allodynia but only one person, who later developed pain, reported an unpleasant sensation...
May 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29733993/attentional-and-interpretational-biases-towards-pain-related-stimuli-in-children-and-adolescents-a-systematic-review-of-the-evidence
#11
REVIEW
M Brookes, L Sharpe, K Kozlowska
This review investigated whether youth exhibit attention or interpretation biases towards pain-related information, and whether such biases are more pronounced in youth with chronic pain. Three databases were searched to identify papers that assessed attention or interpretation biases using an accepted experimental paradigm. Ten studies were identified, eight examining attentional biases and two examining interpretation biases. As in the adult literature, there was no evidence of attentional biases towards pain in youth without chronic pain...
May 4, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29729431/effects-of-cannabinoid-type-2-receptor-agonist-am1241-on-morphine-induced-antinociception-acute-and-chronic-tolerance-and-dependence-in-mice
#12
Mingyue Zhang, Linlin Dong, Huichao Zou, Junnan Li, Quanyi Li, Guonian Wang, Hulun Li
Morphine is a potent opioid analgesic used to alleviate moderate or severe pain but the development of drug tolerance and dependence limits its use in pain management. Previous studies showed that cannabinoid type 2 (CB2 ) receptor ligands may modulate opioid effects. However, there is no report of the effect of CB2 receptor agonist on acute morphine tolerance and physical dependence. We therefore investigated the effect of a CB2 receptor agonist (AM1241) on morphine-induced morphine tolerance and physical dependence in mice...
May 2, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29723560/associations-between-catecholaminergic-and-serotonergic-genes-and-persistent-breast-pain-phenotypes-following-breast-cancer-surgery
#13
Mitchell R Knisely, Yvette P Conley, Kord M Kober, Betty Smoot, Steven M Paul, Jon D Levine, Christine Miaskowski
Genetic variations in the catecholaminergic and serotonergic pathways may contribute to the development and severity of persistent breast pain. However, investigations of these associations are limited. The purpose of this study was to evaluate for associations between breast pain phenotypes and single nucleotide polymorphisms (SNPs) among 15 genes involved in catecholaminergic and serotonergic neurotransmission. Women rated the presence and intensity of breast pain monthly for six months following breast cancer surgery...
April 30, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29715520/-i-was-a-little-surprised-qualitative-insights-from-patients-enrolled-in-a-12-month-trial-comparing-opioids-to-non-opioid-medications-for-chronic-musculoskeletal-pain
#14
Marianne S Matthias, Melvin T Donaldson, Agnes C Jensen, Erin E Krebs
Chronic musculoskeletal pain is a major public health problem. Although opioid prescribing for chronic pain has increased dramatically since the 1990s, this practice has come under scrutiny because of increases in opioid-related harms and lack of evidence for long-term effectiveness. The Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) trial was a pragmatic 12-month randomized trial comparing benefits and harms of opioid versus non-opioid medications for chronic musculoskeletal pain. The current qualitative study was designed to better understand trial results by exploring patients' experiences, including perceptions of medications, experiences with the intervention, and whether expectations were met...
April 28, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29715519/oxidative-stress-contributes-to-fracture-cast-induced-inflammation-and-pain-in-a-rat-model-of-complex-regional-pain-syndrome
#15
Tian-Zhi Guo, Tzuping Wei, Ting-Ting Huang, Wade S Kingery, John David Clark
Clinical evidence suggests vitamin C (Vit C) may protect against the development of complex regional pain syndrome (CRPS) after fracture and/or surgery. Tibia fracture followed by 4 weeks cast immobilization (fracture/cast) in rats results in nociceptive, vascular, and bone changes resembling clinical CRPS. In the present study, fracture/cast rats were treated with the oxidative stress inhibitors Vit C, N-acetyl cysteine (NAC) or 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL) to examine their effects on CRPS-related nociceptive and vascular changes...
April 28, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29705347/prevalence-and-correlates-of-low-pain-interference-among-patients-with-high-pain-intensity-who-are-prescribed-long-term-opioid-therapy
#16
Melissa H Adams, Steven K Dobscha, Ning X Smith, Bobbi Jo Yarborough, Richard A Deyo, Benjamin J Morasco
The pain experience may vary greatly among individuals reporting equally high levels of pain. We sought to examine demographic and clinical characteristics associated with pain interference in patients with high pain intensity. Among patients with chronic musculoskeletal pain who were prescribed long-term opioid therapy (LTOT), who were recruited from two healthcare systems, we identified a subset who reported high pain intensity (n=189). All individuals completed self-report assessments of clinical and demographic factors...
April 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29702257/verbal-instruction-can-induce-extinction-of-fear-of-movement-related-pain
#17
Yoshiki Maeda, Shigeyuki Kan, Yuji Fujino, Masahiko Shibata
The fear avoidance model of chronic musculoskeletal pain highlights the importance of pain-related fear in chronification of pain. Although several interventions have been developed based on this model, the following issues remain unresolved: first, whether movement conditioned to pain can evoke fear responses particularly sympathetic activation; second, whether verbal instructions can attenuate conditioned fear of movement-related pain as with direct experience. To investigate these issues, we induced proprioceptive conditioning (learning the relationship between proprioceptive sensations and an aversive event) and extinction learning in healthy volunteers, and we compared psychophysiological and subjective indices of fear between an Instructed and a Normal extinction group...
April 24, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29684510/the-rodent-tibia-fracture-model-a-critical-review-and-comparison-with-the-complex-regional-pain-syndrome-literature
#18
REVIEW
Frank Birklein, Alaa Ibrahim, Tanja Schlereth, Wade S Kingery
Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified as the primary source of cutaneous cytokines and NGF...
April 20, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29678564/prescription-medication-use-among-community-based-us-adults-with-chronic-low-back-pain-a-cross-sectional-population-based-study
#19
Anna Shmagel, Linh Ngo, Kristine Ensrud, Robert Foley
Many classes of medications have been evaluated in chronic low back pain (cLBP), however their utilization in the community remains unclear. We examine patterns of prescription medication use among Americans with cLBP in a nationally representative, community-based sample. The Back Pain Survey was administered to a representative sample of US adults aged 20-69 (N = 5103) during the 2009-2010 cycle of the National Health and Nutrition Examination Survey (NHANES). cLBP was defined as self-reported pain in the area between the lower posterior margin of the ribcage and the horizontal gluteal fold on most days for at least 3 months (N = 700)...
April 17, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29678563/pilot-randomized-trial-of-integrated-cognitive-behavioral-therapy-and-neuromuscular-training-for-juvenile-fibromyalgia-the-fit-teens-program
#20
Susmita Kashikar-Zuck, William R Black, Megan Pfeiffer, James Peugh, Sara E Williams, Tracy V Ting, Staci Thomas, Katie Kitchen, Gregory D Myer
Cognitive-behavioral therapy (CBT) improves coping and daily functioning in adolescents with juvenile fibromyalgia (JFM), but is less effective in reducing pain. This pilot trial evaluated the efficacy of a novel intervention (Fibromyalgia Integrative Training for Teens; FIT Teens) which integrates CBT with specialized neuromuscular exercise training to enhance the impact of treatment on reducing pain and disability. Forty adolescents with JFM (12-18 years) were randomized to CBT-only or FIT Teens. Treatment was conducted in group-based sessions over 8 weeks with assessments at baseline, post-treatment, and 3-month follow-up (primary endpoint)...
April 17, 2018: Journal of Pain: Official Journal of the American Pain Society
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