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Journal of Pain: Official Journal of the American Pain Society

Jiang Wu, Mark Hocevar, Bihua Bie, Joseph F Foss, Mohamed Naguib
Paclitaxel induces microglial activation and production of proinflammatory mediators in the dorsal horn, which contribute to the development and maintenance of central sensitization and pain behavior. MDA7, 1-((3-benzyl-3-methyl-2,3-dihydro-1-benzofuran-6-yl)carbonyl) piperidine is a novel highly selective CB2 agonist. We tested the hypothesis that activation of CB2 receptor by MDA7 modulates microglial dysregulation, suppresses the overexpression of brain-derived neurotrophic factor (BDNF) in microglia in the dorsal horn, and attenuates the central sensitization and pain behavior induced by paclitaxel...
November 8, 2018: Journal of Pain: Official Journal of the American Pain Society
Victoria J Madden, Peter Kamerman, Valeria Bellan, Mark J Catley, Leslie N Russek, Danny Camfferman, G Lorimer Moseley
In experiments on pain, participants are frequently exposed to non-painful and painful stimuli, yet the conventional pain-rating scales lack a non-painful range and a clear point of transition from non-painful to painful events. The Sensation and Pain Rating Scale (SPARS) assesses the full stimulus intensity range, extending from no sensation (rating: -50) to worst pain imaginable (rating: +50), and it explicitly identifies pain threshold (rating: 0). Here, we tested the SPARS in two experiments using laser heat stimuli to establish its stimulus-response characteristics (Experiment 1, n = 19, 13 stimulus intensities applied 26 times each across a 1-4J range), and to compare it to 0-100 scales that assess non-painful (0: no sensation, 100: pain) and painful (0: no pain, 100: worst pain imaginable) events (Experiment 2, n = 7, 9 stimulus intensities applied 36 times each across a 1...
November 1, 2018: Journal of Pain: Official Journal of the American Pain Society
Jennifer Y F Lau, Eva Sprecher, Sara Haas, Stephen Lisk, David Pagliaccio, Louise Sharpe, Yair Bar-Haim, Daniel S Pine
Persistent pain in young people in the community is common but individuals vary in how much pain impacts daily life. Information-processing accounts of chronic pain partly attribute the fear and avoidance of pain, and associated interference to a set of involuntary biases, including the preferential allocation of attention resources towards potential threats. Far less research has focused on the role of voluntary goal-directed attention control processes, the ability to flexibly direct attention towards and away from threats, in explaining pain-associated interference...
October 29, 2018: Journal of Pain: Official Journal of the American Pain Society
Marc O Martel, Kristian Petersen, Marise Cornelius, Lars Arendt-Nielsen, Robert Edwards
It is generally assumed that individuals exhibiting high pain inhibition also tend to exhibit low pain facilitation, but little research has examined this association in individuals with pain. The aims of this cross-sectional study were 1) to examine the association between measures of conditioned pain modulation (CPM) and temporal summation (TS) in individuals with chronic pain and 2) to examine whether this association was moderated by demographic (age, sex), psychological (depression, catastrophizing), or medication-related (opioid use) variables...
October 29, 2018: Journal of Pain: Official Journal of the American Pain Society
Neal Slatkin, Naim Zaki, Steven Wang, John Louie, Panna Sanga, Kathleen M Kelly, John Thipphawong
This randomized, double-blind (DB), placebo-controlled, phase 2 study assessed the efficacy and safety of fulranumab as a pain therapy adjunctive to opioids in terminally-ill cancer patients. Ninety-eight patients were randomized (2:1) to receive one subcutaneous injection of fulranumab (9 mg) or placebo in the 4-week DB phase. Seventy-one (72%) patients entered the 48-week open-label extension phase and were administered 9 mg fulranumab every 4 weeks. The study failed to demonstrated efficacy at the end of the DB phase (primary endpoint, mean (SD) change in average cancer-related pain intensity was -0...
October 24, 2018: Journal of Pain: Official Journal of the American Pain Society
Nai-Jiang Liu, Emiliya M Storman, Alan R Gintzler
We previously showed that spinal mGluR1 signaling suppresses or facilitates (depending on stage of estrous cycle) analgesic responsiveness to intrathecal endomorphin 2 (EM2), a highly mu-opioid receptor (MOR)-selective endogenous opioid. Spinal EM2 antinociception is suppressed during diestrus by mGluR1 when it is activated by membrane estrogen receptor alpha (mERα), and facilitated during proestrus when mGluR1 is activated by glutamate. In the current study, we tested the hypothesis that in female rats subjected to spinal nerve ligation (SNL), inhibition of spinal estrogen synthesis or blockade of spinal mERα/mGluR1 would be anti-allodynic during diestrus, whereas during proestrus mGluR1 blockade would worsen the mechanical allodynia...
October 23, 2018: Journal of Pain: Official Journal of the American Pain Society
Tong Wang, Lian Lian Yang, Zhou Yang, Xi Ting Huang
Self-distancing has been shown to alleviate emotional pain and also to have potential efficacy for treating chronic pain and imagined acute pain, relative to self-immersing. This study examined the efficacy of self-distancing in relieving acute physical pain caused by a cold pressor task (CPT) in healthy adults. Sixty-five undergraduates were pseudo-randomly assigned to one of three groups: a) a self-distancing group instructed to "take a step back" to simulate their current painful experience as an observer; b) a self-immersed group in which simulating their current painful experience from the egocentric perspective; or c) a control group in which participants cope with pains in their spontaneous ways...
October 16, 2018: Journal of Pain: Official Journal of the American Pain Society
Mélanie Racine, Mark P Jensen, Manfred Harth, Patricia Morley-Forster, Warren R Nielson
This study's aim was to assess the efficacy of two forms of activity pacing in patients with fibromyalgia syndrome (FMS). Treatment-related changes in activity management patterns were also examined. Patients with FMS (N = 178) were randomly assigned to an operant learning (OL; delayed [N = 36] or immediate [N = 54] groups) or an energy conservation (EC; delayed [N = 35] or immediate [N = 53] groups) treatment condition. Of these, 32 OL and 37 EC patients completed treatment. Forty-three patients were allocated to the delayed treatment condition (Control group)...
October 13, 2018: Journal of Pain: Official Journal of the American Pain Society
He Gu, Daisuke Sugiyama, Sinyoung Kang, Timothy J Brennan
Translational correlates to pain with activities after deep tissue injury have been rarely studied. We hypothesized that deep tissue incision causes greater activation of nociception-transmitting neurons evoked by muscle contraction. In vivo neuronal activity was recorded in 203 dorsal horn neurons (DHNs) from 97 rats after sham, skin-only, or skin + deep muscle incision. We evaluated DHN responses to static, isometric muscle contractions induced by direct electrical stimulation of the muscle. The effect of pancuronium on DHN response to contractions was also examined...
October 6, 2018: Journal of Pain: Official Journal of the American Pain Society
Sanneke Don, Maarten Venema, Margot De Kooning, Bart van Buchem, Jo Nijs, Lennard Voogt
Chronic low back pain (CLBP) has major public health implications and underlying mechanisms are still unclear. Sensorimotor incongruence (SMI) - an ongoing mismatch between top down motor output and predicted sensory feedback - may play a role in the course of chronic non-specific low back pain. The hypothesis of this study was that the induction of SMI causes sensory disturbances and/or pain in people with CLBP and healthy volunteers. A sample of 66 people (33 people with CLBP and 33 healthy volunteers) participated in a visual feedback experiment involving real time images of the own lower back - either during movement or in a static position - provided via a live video feed...
October 5, 2018: Journal of Pain: Official Journal of the American Pain Society
Eveliina Glogan, Christine van Vliet, Rani Roelandt, Ann Meulders
In chronic pain, pain-related fear seems to overgeneralize to safe stimuli, thus contributing to excessive fear and avoidance behavior. Evidence shows that pain-related fear can be acquired and generalized based on conceptual knowledge. Using a fear conditioning paradigm, we investigated whether this concept-based pain-related fear could also be extinguished. During acquisition, exemplars of one action category (conditioned stimuli; CSs) were followed by pain (CS+; e.g. opening boxes), whereas exemplars of another action category were not (CS-; e...
October 5, 2018: Journal of Pain: Official Journal of the American Pain Society
Vanessa E Miller, Charles Poole, Yvonne Golightly, Deborah Barrett, Ding-Geng Chen, Richard Ohrbach, Joel D Greenspan, Roger B Fillingim, Gary D Slade
High-impact (disabling) pain diminishes quality of life and increases health care costs. The purpose of this study was to identify variables that distinguish between high and low-impact pain among individuals with painful temporomandibular disorder (TMD). Community-dwelling adults (n=846) with chronic TMD completed standardized questionnaires assessing the following: 1) sociodemographic, 2) psychological distress, 3) clinical pain, and 4) experimental pain. We used high-impact pain, classified using the Graded Chronic Pain Scale, as the dependent variable in logistic regression modeling to evaluate contributions of variables from each domain...
October 4, 2018: Journal of Pain: Official Journal of the American Pain Society
Sara Kindt, Maarten Vansteenkiste, Katrijn Brenning, Liesbet Goubert
To understand when and why the provision of help by a partner of an individual with chronic pain (ICP) yields benefits, it is critical, according to self-determination theory, to consider the extent to which partners' helping responses are supportive of the basic psychological needs of the ICP, as well as the motivations underlying these helping responses. The present study (N = 141 couples), spanning 3 measurement moments over 6 months, investigated temporal associations between partners' helping motivation, ICPs' psychological needs, and ICPs' functioning across time (ie, well-being, psychological distress, and disability)...
October 4, 2018: Journal of Pain: Official Journal of the American Pain Society
Tonya M Palermo, Margaret Slack, Chuan Zhou, Rachel Aaron, Emma Fisher, Sade Rodriguez
Chronic pain during childhood is prevalent and costly but access to interdisciplinary pain care is limited. Studies investigating adults waiting for pain clinic evaluation found that symptoms and quality of life deteriorate over the waiting period, but little is known about the experience of adolescents. Therefore, we aimed to determine waitlist times and longitudinal trends of pain, physical, mental and social health over a 12-week period. Ninety-seven adolescents, ages 10-18 years (M age= 14.7 years; 82% female) waiting for evaluation at an interdisciplinary pediatric pain clinic completed assessments at enrollment, four, eight, and 12-week follow-up...
October 3, 2018: Journal of Pain: Official Journal of the American Pain Society
Renata Hadzic, Louise Sharpe, Bradley Wood, Carolyn MacCann
Despite widespread use as a chronic pain management strategy, pacing has been linked with higher levels of pain and disability. A recent meta-analysis found a positive correlation between existing measures of pacing and avoidance, which may partially account for these poorer outcomes. A measure was developed to differentiate pacing from avoidance by emphasizing non-pain-contingent pacing behaviours and non-avoidance of pain. A sample of 283 adults with chronic pain completed the Non-Avoidant Pacing Scale (NAPS) and existing measures of pacing, avoidance, pain, and physical and psychological functioning...
September 29, 2018: Journal of Pain: Official Journal of the American Pain Society
Robert N Jamison, Xinling Xu, Limeng Wan, Robert R Edwards, Edgar L Ross
This study compared persons with chronic pain who consistently reported that their pain was worsening with those who reported that their pain was improving or remaining the same per daily assessment data from a smartphone pain app. All participants completed baseline measures and were asked to record their progress every day by answering whether their overall condition had improved, remained the same, or gotten worse (perceived change) on a visual analogue scale. One hundred forty-four individuals with chronic pain who successfully entered daily assessments were included...
September 29, 2018: Journal of Pain: Official Journal of the American Pain Society
Els Mehuys, Geert Crombez, Koen Paemeleire, Els Adriaens, Thierry Van Hees, Sophie Demarche, Thierry Christiaens, Luc Van Bortel, Inge Van Tongelen, Jean-Paul Remon, Koen Boussery
Pain is a common reason for self-medication with over-the-counter (OTC) analgesics. However, this self-treating population has remained largely uncharacterized. This cross-sectional observational study investigated individuals who self-medicate their pain with OTC analgesics to elucidate their pain characteristics and medication use. In addition, presence of and risk factors for concerns about pain medication were examined. The clinical profile of the participants (n = 1,889) was worse than expected with long-standing pain complaints (median pain duration of 9 years), pain located at multiple body sites (median of 4, and 13% with ≥10 painful body areas), about one-third suffering from daily pain and about 40% experiencing substantial pain-related disability...
September 28, 2018: Journal of Pain: Official Journal of the American Pain Society
Sangtae Ahn, Julianna H Prim, Morgan L Alexander, Karen L McCulloch, Flavio Fröhlich
Chronic pain is associated with maladaptive reorganization of the central nervous system. Recent studies have suggested that disorganization of large-scale electrical brain activity patterns, such as neuronal network oscillations in the thalamocortical system, plays a key role in the pathophysiology of chronic pain. Yet, little is known about whether and how such network pathologies can be targeted with noninvasive brain stimulation as a nonpharmacological treatment option. We hypothesized that alpha oscillations, a prominent thalamocortical activity pattern in the human brain, are impaired in chronic pain and can be modulated with transcranial alternating current stimulation (tACS)...
September 27, 2018: Journal of Pain: Official Journal of the American Pain Society
Juliane Sachau, Henrike Bruckmueller, Janne Gierthmühlen, Walter Magerl, Meike Kaehler, Sierk Haenisch, Andreas Binder, Amke Caliebe, Christoph Maier, Rolf-Detlef Treede, Thomas Tölle, Ingolf Cascorbi, Ralf Baron
Pain sensitivity is characterized by interindividual variability, determined by factors including genetic variation of nociceptive receptors and pathways. The sigma-1 receptor (SIGMAR1) is involved in pain modulation especially under pre-sensitized conditions. However, the contribution of SIGMAR1 genetic variants to pain generation and sensitivity is unknown yet. This study aimed to identify effects of 5 SIGMAR1 variants on the somatosensory phenotype of neuropathic pain patients (n = 228) characterized by standardized quantitative sensory testing...
September 25, 2018: Journal of Pain: Official Journal of the American Pain Society
Peter C Poortvliet, Kylie J Tucker, Simon Finnigan, Dion Scott, Paul W Hodges
Differences in neural drive could explain variation in adaptation to acute pain between postural and voluntary motor actions. We investigated whether cortical contributions, quantified by corticomuscular coherence, are affected differently by acute experimental pain in more posturally focused position-control tasks and voluntary focused force-control tasks. Seventeen participants performed position- and force-control contractions with matched loads (10% maximum voluntary contraction) before and during pain (injection of hypertonic saline into the infrapatellar fat pad of the knee)...
September 25, 2018: Journal of Pain: Official Journal of the American Pain Society
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