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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/29325884/experimental-low-back-pain-decreased-trunk-muscle-activity-in-currently-asymptomatic-recurrent-low-back-pain-patients-during-step-tasks
#1
Lars Henrik Larsen, Rogerio Pessoto Hirata, Thomas Graven-Nielsen
Low back pain (LBP) patients demonstrate reorganized trunk muscle activity but if similar changes are manifest in recurrent LBP patients (R-LBP) during asymptomatic periods remains unknown. In 26 healthy and 27 currently asymptomatic R-LBP participants electromyographic activity (EMG) was recorded from trunk and gluteal muscles during series of stepping up and down on a step bench before and during experimentally intramuscular induced unilateral and bilateral LBP. Pain intensity was assessed by numeric rating scale (NRS) scores...
January 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29325883/a-functional-neuroimaging-study-of-expectancy-effects-on-pain-response-in-patients-with-knee-osteoarthritis
#2
Randy L Gollub, Irving Kirsch, Nasim Maleki, Ajay D Wasan, Robert R Edwards, Yiheng Tu, Ted J Kaptchuk, Jian Kong
Placebo treatments and healing rituals share much in common, such as the effects of expectancy, and have been used since the beginning of human history to treat pain. Previous mechanistic neuroimaging studies investigating the effects of expectancy on placebo analgesia have used young, healthy volunteers. Using functional magnetic resonance imaging (fMRI), we aimed to investigate the neural mechanisms by which expectancy evokes analgesia in older adults living with a chronic pain disorder and determine whether there are interactions with active treatment...
January 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29309891/daily-anxiety-and-depressive-symptoms-in-couples-coping-with-vulvodynia-associations-with-women-s-pain-women-s-sexual-function-and-both-partners-sexual-distress
#3
Myriam Pâquet, Natalie O Rosen, Marc Steben, Marie-Hélène Mayrand, Marie Santerre-Baillargeon, Sophie Bergeron
Vulvodynia is a idiopathic vulvovaginal pain condition that interferes with the sexual and mental health of affected couples. Research has underscored that psychological factors, such as anxiety and depression, are associated with its development and maintenance and related sexual impairment. However, the daily role of anxiety and depressive symptoms in the pain and sexuality outcomes of couples coping with vulvodynia is not well understood. Using a dyadic daily experience method, 127 women (Mage = 26.21, SD = 6...
January 5, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29307749/inflammatory-and-neuropathic-pain-from-bench-to-bedside-what-went-wrong
#4
REVIEW
Robert P Yezierski, Per Hansson
In recent years, the disappointing history of translation in the field of pain research has undergone significant scrutiny. The escalation of knowledge and understanding related to presumed pain in neuropathic and inflammatory animal models contrasted with the unsatisfactory record of "bench-to-bedside" translation has raised many questions about the validity and clinical relevance of preclinical models and methods of behavioral assessment. Although many opinions have been expressed one of the overriding concerns and greatest barriers to the widening gap between preclinical research and the development of new interventions has been the underappreciated distinction between pain and nociception...
January 4, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29307748/number-and-type-of-post-traumatic-stress-disorder-ptsd-symptom-domains-are-associated-with-patient-reported-outcomes-in-patients-with-chronic-pain
#5
Dale J Langford, Brian R Theodore, Danica Balsiger, Christine Tran, Ardith Z Doorenbos, David J Tauben, Mark D Sullivan
Post-Traumatic Stress Disorder (PTSD) commonly accompanies complex chronic pain, yet PTSD is often overlooked in chronic pain management. Using the 4-item Primary Care (PC)-PTSD screening tool, we evaluated the relationship between the number and type of PC-PTSD symptoms endorsed and a set of patient-reported outcomes, including: pain intensity and interference; function; mood; quality of life; and substance abuse risk in a consecutive sample of patients with chronic pain (n=4,402). Patients completed PainTracker™, a web-based patient-reported outcome tool that provides a multidimensional evaluation of chronic pain, as part of their intake evaluation at a specialty pain clinic in a community setting...
January 4, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29274393/the-social-regulation-of-pain-autonomic-and-neurophysiological-changes-associated-with-perceived-threat
#6
Xianwei Che, Robin Cash, Paul Fitzgerald, Bernadette M Fitzgibbon
The analgesic effect of social support is proposed as a function of social support modulating perceived threat of painful stimuli. In the current study, we directly examined the social-buffering effect in the context of the threat of pain. Eighteen healthy participants were subjected to the threat of pain while they held the hand of a close other, a stranger, or not at all. Neural and autonomic responses were recorded using electroencephalogram (EEG) and heart rate respectively. Close other hand-holding reduced pain perception...
December 20, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29269281/autonomic-arousal-as-a-mechanism-of-the-persistence-of-nocebo-hyperalgesia
#7
Ben Colagiuri, Veronica F Quinn
Placebo and nocebo mechanisms can lead to clinically significant modulation of pain. Whilst learning is considered to be the broad mechanism underlying both placebo analgesia and nocebo hyperalgesia, critical differences have emerged in their specific mechanisms. One of the most interesting of these is that while placebo analgesia seems to be relatively short-lived, nocebo hyperalgesia appears more resistant to extinction, often persisting indefinitely. The current study examined why nocebo hyperalgesia persists longer than placebo analgesia...
December 18, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29253551/pain-and-fatigue-variability-patterns-distinguish-subgroups-of-fibromyalgia-patients
#8
Emily J Bartley, Michael E Robinson, Roland Staud
The current study examined between- and within-subject variability in pain-related symptoms as predictors of pain and fatigue, and identified patient subgroups based upon symptom variability characteristics. Two hundred and fifty-six fibromyalgia (FM) patients completed daily diaries up to a period of 154 days and reported on symptoms of pain intensity, pain unpleasantness, fatigue, anxiety, and depressed mood. Measures of health status, quality of life, and somatic symptoms were obtained at baseline, and hierarchical linear modeling and cluster analyses were employed...
December 15, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29248511/daily-fluctuations-of-progesterone-and-testosterone-are-associated-with-fibromyalgia-pain-severity
#9
Meredith Schertzinger, Kate Wesson-Sides, Luke Parkitny, Jarred Younger
The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives. Cortisol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum. A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity...
December 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29248510/feeling-the-pressure-to-be-perfect-impact-on-pain-related-distress-and-dysfunction-in-youth-with-chronic-pain
#10
Edin T Randall, Kelly R Smith, Corey A Kronman, Caitlin Conroy, Allison M Smith, Laura E Simons
Despite clinical observation of perfectionistic tendencies among youth with chronic pain and their parents as well as established relationships between perfectionism and functional somatic symptoms in adults and youth, no research in the pediatric pain literature has examined perfectionism. This study explored the role of various types of youth and parent perfectionism on youth and parent pain-related distress and behavior and youth pain-related dysfunction. At admission, 239 parent-child pairs from outpatient and day-treatment rehabilitation settings completed several questionnaires assessing perfectionism, pain-related distress, and pain-related dysfunction...
December 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29247851/the-involvement-of-the-endocannabinoid-system-in-the-peripheral-antinociceptive-action-of-ketamine
#11
Renata C M Ferreira, Marina G M Castor, Fabiana Piscitelli, Vincenzo Di Marzo, Igor D G Duarte, Thiago R L Romero
Ketamine has been widely used as an analgesic and produces dissociative anesthetic effects. The antinociceptive effects of ketamine have been studied, but the involvement of endocannabinoids in these effects has not yet been investigated. In this study, we evaluated the involvement of the endocannabinoid system in the peripheral antinociceptive effects induced by ketamine. All drugs were administered via the intraplantar route. To induce hyperalgesia, rat paws were injected with prostaglandin E2 (PGE2, 2 µg/paw)...
December 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29241836/opposite-effects-of-stress-on-pain-modulation-depend-on-the-magnitude-of-individual-stress-response
#12
Nirit Geva, Ruth Defrin
The effect of acute stress on pain threshold and intolerance threshold are reported as producing either hypoalgesia or hyperalgesia. Yet, the contribution of individual stress reactivity in this respect has not been established. The aim was to test two pain modulation paradigms under acute stress manipulation, here for the first time, in order to study whether stress differentially affects pain modulation, and whether the effect is related to individual stress response. Participants were 31 healthy subjects...
December 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29241835/the-impact-of-a-statewide-mandatory-prescription-drug-monitoring-program-on-opioid-prescribing-by-emergency-medicine-providers-across-15-hospitals-in-a-single-health-system
#13
Brian Suffoletto, Michael Lynch, Charissa B Pacella, Donald M Yealy, Clifton W Callaway
Prescription drug monitoring programs (PDMP) enable registered prescribers to obtain real-time information on patients' prescription history of controlled medications. We sought to describe the impact of a state-mandated PDMP on opioid prescribing by Emergency Medicine providers. We retrospectively analyzed electronic medical records of 122,732 adult patients discharged with an opioid prescription from 15 Emergency Departments in a single health system in Pennsylvania from July 2015 to March, 2017. We used an interrupted time-series design to evaluate the percentage of patients discharged each month with an opioid prescription before and after state law mandated PDMP use on August 25th, 2016...
December 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29241834/efficacy-and-safety-of-oral-and-transdermal-opioid-analgesics-for-musculoskeletal-pain-in-older-adults-a-systematic-review-of-randomized-placebo-controlled-trials
#14
REVIEW
Rodrigo Z Megale, Leticia A Deveza, Fiona M Blyth, Vasi Naganathan, Paulo H Ferreira, Andrew J McLachlan, Manuela L Ferreira
This systematic review with meta-analysis was performed to evaluate the efficacy and safety of using opioid analgesics in older adults with musculoskeletal pain. We searched Cochrane Library, MEDLINE, EMBASE, Web of Science, AMED, CINAHL and LILACS for randomized controlled trial with mean population age of 60 years or older, comparing the efficacy and safety of opioid analgesics with placebo for musculoskeletal pain conditions. Reviewers extracted data, assessed risk of bias and evaluated the quality of evidence using the GRADE approach...
December 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29229431/altered-neurocognitive-processing-of-tactile-stimuli-in-patients-with-complex-regional-pain-syndrome-crps
#15
Anoop Kuttikat, Valdas Noreika, Srivas Chennu, Nicholas Shenker, Tristan Bekinschtein, Christopher A Brown
Chronic pain in CRPS has been linked to tactile misperceptions and deficits in somatotopic representation of the affected limb. Here, we identify altered cognitive processing of tactile stimuli in CRPS patients that we propose marks heterogeneity in tactile decision-making mechanisms. In a case-control design, we compared middle and late-latency somatosensory-evoked potentials (SEPs) in response to pseudo-randomised mechanical stimulation of the digits of both hands (including CRPS-affected and non-affected sides) between 13 CRPS patients and 13 matched healthy controls...
December 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29229430/self-guided-online-cognitive-behavioral-strategies-for-chemotherapy-induced-peripheral-neuropathy-a-multicenter-pilot-randomized-wait-list-controlled-trial
#16
Robert Knoerl, Ellen M L Smith, Debra L Barton, David A Williams, Janean E Holden, John C Krauss, Beth LaVasseur
The purpose of this pilot, parallel, randomized-controlled trial was to examine the efficacy of a self-guided online cognitive and behaviorally-based pain management intervention (PROSPECT) to reduce "worst" pain for individuals with chronic painful chemotherapy-induced peripheral neuropathy (CIPN). Secondary outcomes included "average" pain, non-painful CIPN symptom severity, impression of change, and pain interference. Sixty patients with chronic painful CIPN were recruited from five outpatient academic and community cancer centers...
December 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29224919/assessment-of-tapentadol-api-abuse-liability-with-the-researched-abuse-diversion-and-addiction-related-surveillance-radars-system
#17
Suzanne K Vosburg, S Geoffrey Severtson, Richard C Dart, Theodore J Cicero, Steven P Kurtz, Mark W Parrino, Jody L Green
Tapentadol, a Schedule II opioid with a combination of µ-opioid activity and norepinephrine reuptake inhibition, is used for the management of moderate to severe acute and chronic pain. Its dual-mechanism of action is thought to reduce opioid-related side effects that can complicate pain management. Since approval, tapentadol has been tracked across multiple outcomes suggesting abuse liability, and a pattern of relatively low, although not absent, abuse liability has been found. This retrospective cohort study further details the abuse liability of tapentadol as an Active Pharmaceutical Ingredient (API) when both immediate-release and extended-release formulations were on the market together (4Q2011 to 2Q2016)...
December 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29198933/dimensionality-and-reliability-of-the-central-sensitization-inventory-csi-in-a-pooled-multi-country-sample
#18
Antonio I Cuesta-Vargas, Randy Neblett, Alessandro Chiarotto, Jeroen Kregel, Jo Nijs, C P van Wilgen, Laurent Pitance, Aleksandar Knezevic, Robert J Gatchel, Tom G Mayer, Carlotta Viti, Cristina Roldan-Jiménez, Marco Testa, Wolnei Caumo, Milica Jeremic-Knezevic, Juan V Luciano
Central Sensitization (CS) involves the amplification of neural signaling within the central nervous system, which evokes pain hypersensitivity. The Central Sensitization Inventory (CSI) assesses 25 overlapping health-related symptom dimensions that have been found to be associated with CS-related disorders. Previous studies have found satisfactory test-retest reliability and internal consistency, but factor analyses have exhibited conflicting results in different language versions. The purpose of this cross-sectional study was to thoroughly examine the dimensionality and reliability of the CSI, with pooled data from 1,987 individuals, collected in several countries...
November 30, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29198932/acupuncture-for-chronic-pain-update-of-an-individual-patient-data-meta-analysis
#19
REVIEW
Andrew J Vickers, Emily A Vertosick, George Lewith, Hugh MacPherson, Nadine E Foster, Karen J Sherman, Dominik Irnich, Claudia M Witt, Klaus Linde
Despite wide use in clinical practice, acupuncture remains a controversial treatment for chronic pain. Our objective was to update an individual patient data meta-analysis to determine the effect size of acupuncture for four chronic pain conditions.We searched MEDLINE and the Cochrane Central Registry of Controlled Trials randomized trials published up until December 31, 2015. We included randomized trials of acupuncture needling versus either sham acupuncture or no acupuncture control for non-specific musculoskeletal pain, osteoarthritis, chronic headache, or shoulder pain...
November 30, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29191774/endogenous-pain-modulation-induced-by-extrinsic-and-intrinsic-psychological-threat-in-healthy-individuals
#20
William Gibson, Penny Moss, Tak Ho Cheng, Alexandre Garnier, Anthony Wright, Benedict M Wand
Many factors interact to influence threat perception and the subsequent experience of pain. This study investigated the impact of observing pain (extrinsic threat) and intrinsic threat of pain to oneself on pressure pain threshold (PPT). Forty socially-connected pairs of healthy volunteers were threat-primed and randomly allocated to experimental or control roles. An experimental pain modulation paradigm was applied, with non-nociceptive threat cues used as conditioning stimuli. In sub-study 1, the extrinsic threat to the experimental participant was observation of the control partner in pain...
November 27, 2017: Journal of Pain: Official Journal of the American Pain Society
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