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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/28344101/predictors-of-acute-post-surgical-pain-following-inguinal-hernioplasty
#1
Patrícia R Pinto, Artur Vieira, Diamantino Pereira, Armando Almeida
Acute post-surgical pain (APSP) is a common and anticipated problem after surgery with detrimental consequences if not appropriately managed. This study examined the independent and joint contribution of pre-surgical demographic, clinical and psychological variables as predictors of APSP intensity, evaluated through an 11-point numerical rating scale, after inguinal hernioplasty, one of the most performed surgeries worldwide. In a prospective observational cohort study, a consecutive sample of 135 men undergoing hernioplasty was assessed before (T1) and 48 hours after (T2) surgery...
March 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28344100/facilitated-pro-nociceptive-pain-mechanisms-in-radiating-back-pain-compared-with-localized-back-pain
#2
Henrik Bjarke Vaegter, Thorvaldur Skuli Palsson, Thomas Graven-Nielsen
Facilitated pain mechanisms and impaired pain inhibition are often found in chronic pain patients. This study compared clinical pain profiles, pain sensitivity, as well as pro-nociceptive and anti-nociceptive mechanisms in patients with localized low back pain (n=18), localized neck pain (n=17), low back and radiating leg pain (n=18), or neck and radiating arm pain (n=17). It was hypothesized that patients with radiating pain had facilitated pain mechanisms and impaired pain inhibition compared with localized pain patients...
March 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28342891/cost-utility-of-group-acceptance-and-commitment-therapy-for-fibromyalgia-versus-recommended-drugs-an-economic-analysis-alongside-a-6-month-randomised-controlled-trial-conducted-in-spain-effigact-study
#3
Juan V Luciano, Francesco D'Amico, Albert Feliu-Soler, Lance M McCracken, Jaume Aguado, María T Peñarrubia-María, Martin Knapp, Antoni Serrano-Blanco, Javier García-Campayo
The aim of this study was to analyse the cost-utility of a group-based form of Acceptance and Commitment Therapy (GACT) in patients with fibromyalgia (FM) compared to patients receiving recommended pharmacological treatment (RPT) or on a waiting list (WL). The data were derived from a previously published study, an RCT that focused on clinical outcomes. Health economic outcomes included health-related quality of life and healthcare use at baseline and at 6-month follow-up using the EuroQol (EQ-5D-3L) and the Client Service Receipt Inventory (CSRI), respectively...
March 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28323246/the-role-of-spinal-gabab-receptors-in-cancelr-induced-bone-pain-in-rats
#4
Ya-Qun Zhou, Shu-Ping Chen, Dai-Qiang Liu, Anne Manyande, Wen Zhang, Shao-Bing Yang, Bing-Rui Xiong, Qiao-Chu Fu, Zhen-Peng Song, Heike Rittner, Da-Wei Ye, Yu-Ke Tian
Cancer-induced bone pain (CIBP) remains a major challenge in advanced cancer patients due to our lack of understanding of its mechanisms. Previous studies have demonstrated the vital role of GABAB receptors (GABABRs) in regulating nociception and various neuropathic pain models have shown diminished activity of GABABRs. However, the role of spinal GABABRs in CIBP remains largely unknown. In this study, we investigated the specific cellular mechanisms of GABABRs in the development and maintenance of CIBP in rats...
March 18, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28300651/sleep-fragmentation-hypersensitizes-healthy-young-women-to-deep-and-superficial-experimental-pain
#5
Stella Iacovides, Kezia George, Peter Kamerman, Fiona C Baker
The effect of sleep deprivation on pain sensitivity has typically been studied using total and partial sleep deprivation protocols. These protocols do not mimic the fragmented pattern of sleep disruption usually observed in individuals with clinical pain conditions. Therefore, we conducted a controlled-experiment to investigate the effect of sleep fragmentation on pain perception (deep pain: forearm muscle ischaemia, and superficial pain: graded pin-pricks applied to the skin) in 11 healthy young women following two consecutive nights of sleep fragmentation, compared with a normal night of sleep...
March 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28300650/painful-after-sensations-in-fibromyalgia-are-linked-to-catastrophizing-and-differences-in-brain-response-in-the-medial-temporal-lobe
#6
Kristin L Schreiber, Marco L Loggia, Jieun Kim, Christine M Cahalan, Vitaly Napadow, Robert R Edwards
Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain, hyperalgesia, and other disabling symptoms. While the brain response to experimental pain in FM patients has been the object of intense investigation, the biological underpinnings of painful after-sensations (PAS), and their relation to negative affect have received little attention. In this cross-sectional cohort study, subjects with FM (n=53) and healthy controls (n=17) were assessed for PAS by exposure to a sustained, moderately painful cuff stimulus to the leg, individually calibrated to a target pain intensity of 40/100...
March 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28279705/lower-placebo-responses-after-long-term-exposure-to-fibromyalgia-pain
#7
Eva Kosek, Annelie Rosen, Serena Carville, Ernest Choy, Richard H Gracely, Hanke Marcus, Frank Petzke, Martin Ingvar, Karin B Jensen
Knowledge about placebo mechanisms in patients with chronic pain is scarce. Fibromyalgia syndrome (FM) is associated with dysfunctions of central pain inhibition, and since placebo analgesia entails activation of endogenous pain inhibition, we hypothesized that long-term exposure to FM pain would negatively affect placebo responses. Here we examined the placebo-group (n=37, mean age 45 years) from a 12-week, randomized, double-blind, placebo-controlled trial investigating the effects of milnacipran or placebo...
March 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28279704/beliefs-about-pharmaceutical-medicines-and-natural-remedies-explain-individual-variation-in-placebo-analgesia
#8
Andrew Watkinson, Sarah C E Chapman, Rob Horne
This study examined whether placebo responses were predicted by a theoretical model of specific and general treatment beliefs. Using a randomised cross-over, experimental design (168 healthy individuals) we assessed whether responses to a cold pressor task were influenced by two placebo creams described as Pharmaceutical vs Natural origin. We assessed whether placebo responses were predicted by pre-treatment beliefs about the treatments (placebo) and by beliefs about the pain. The efficacy of both Pharmaceutical and Natural Placebos in reducing Pain Intensity was predicted by aspects of pain catastrophizing including Feelings of Helplessness (Pharmaceutical: B=0...
March 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28274698/effects-of-short-term-oxycodone-maintenance-on-experimental-pain-responses-in-physically-dependent-opioid-abusers
#9
Marion A Coe, Paul N Nuzzo, Michelle R Lofwall, Sharon L Walsh
A common clinical problem with opioid analgesics is the loss of analgesic efficacy after repeated dosing; when this occurs, it is not clear what principles should guide providing effective analgesia among opioid-dependent individuals. This within-subject inpatient study aimed to determine if physically dependent opioid abusers (n=11) experience changes in oxycodone-induced analgesia during two oxycodone maintenance (30mg p.o./q.i.d.) phases: Initial Stabilization (Days 1 - 3) and after 6 weeks of Chronic Dosing...
March 5, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28274697/pain-catastrophizing-and-negative-mood-states-following-spinal-cord-injury-transitioning-from-inpatient-rehabilitation-into-the-community
#10
Ashley Craig, Rebecca Guest, Yvonne Tran, Kathryn Nicholson Perry, James Middleton
Chronic pain is prevalent in people with spinal cord injury (SCI). This research investigated how chronic pain intensity and catastrophizing varies in adults with SCI during inpatient rehabilitation up to 12 months post-injury after transitioning into the community. Eighty-eight participants with SCI were assessed for pain intensity and catastrophizing, depressive mood states and cognitive performance. Participants were divided into sub-groups of clinically elevated depressive mood and anxiety versus those with normal mood state levels...
March 5, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28267630/psychometric-evaluation-of-the-pain-attitudes-questionnaire-revised-for-people-with-advanced-cancer
#11
Kenneth Mah, Kim T Tran, Lynn R Gauthier, Gary Rodin, Camilla Zimmermann, David Warr, S Lawrence Librach, Malcolm Moore, Frances A Shepherd, Lucia Gagliese
Pain-related stoicism and cautiousness are theorized to be more prevalent in older than younger patients and to lead to greater pain underreporting and consequently inadequate pain management in older patients. The Pain Attitudes Questionnaire-Revised (PAQ-R), which measures five pain-related stoicism (fortitude, concealment, superiority) and cautiousness (self-doubt, reluctance) factors in chronic pain, can help test this hypothesis in advanced cancer but requires validation. We conducted a psychometric evaluation of the PAQ-R in 155 younger (< 60 years) and 114 older (≥ 60 years) patients with advanced cancer...
March 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28254585/the-potential-role-of-sensory-testing-skin-biopsy-and-functional-brain-imaging-as-biomarkers-in-chronic-pain-clinical-trials-immpact-considerations
#12
REVIEW
Shannon M Smith, Robert H Dworkin, Dennis C Turk, Ralf Baron, Michael Polydefkis, Irene Tracey, David Borsook, Robert R Edwards, Richard E Harris, Tor D Wager, Lars Arendt-Nielsen, Laurie B Burke, Daniel B Carr, Amy Chappell, John T Farrar, Roy Freeman, Ian Gilron, Veeraindar Goli, Juergen Haeussler, Troels Jensen, Nathaniel P Katz, Jeffrey Kent, Ernest A Kopecky, David A Lee, William Maixner, John D Markman, Justin C McArthur, Michael P McDermott, Lav Parvathenani, Srinivasa N Raja, Bob A Rappaport, Andrew S C Rice, Michael C Rowbotham, Jeffrey K Tobias, Ajay D Wasan, James Witter
Valid and reliable biomarkers can play an important role in clinical trials as indicators of biological or pathogenic processes or as a signal of treatment response. Currently, there are no biomarkers for pain qualified by the US Food and Drug Administration or the European Medicines Agency for use in clinical trials. This article summarizes an Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) meeting in which 3 potential biomarkers were discussed for use in the development of analgesic treatments: (1) sensory testing, (2), skin punch biopsy, and (3) brain imaging...
February 27, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28238950/an-improved-rodent-model-of-trigeminal-neuropathic-pain-by-unilateral-chronic-constriction-injury-of-distal-infraorbital-nerve-dion-cci
#13
Weihua Ding, Zerong You, Shiqian Shen, Jinsheng Yang, Grewo Lim, Jason T Doheny, Lucy Chen, Shengmei Zhu, Jianren Mao
The number of studies on trigeminal nerve injury using animal models remains limited. A rodent model of trigeminal neuropathic pain was first developed in the 1994, in which chronic constriction injury is induced by ligation of the infraorbital nerve (IoN-CCI). This animal model has served as a major tool to study trigeminal neuropathic pain. Unfortunately, the surgical procedure in this model is complicated and far more difficult than ligation of peripheral nerves (e.g. sciatic nerve). The aim of this study was to improve on the current surgical procedure of IoN ligation to induce trigeminal neuropathic pain in rats...
February 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28232147/long-term-pain-and-recovery-after-major-pediatric-surgery-a-qualitative-study-with-teens-parents-and-perioperative-care-providers
#14
Jennifer A Rabbitts, Rachel V Aaron, Emma Fisher, Emily A Lang, Caroline Bridgwater, Gabrielle Ghafari Tai, Tonya M Palermo
Research developing targeted treatment focused on coping with children's long-term pain after surgery is needed due to the high prevalence of chronic pain after surgery. This qualitative study aimed to 1) understand the child's and family's experiences of pain over the course of their surgical experience, and 2) gather stakeholder input regarding potential barriers and facilitators of perioperative intervention delivery. Fifteen children ages 10-18 years who underwent recent major surgery, their primary caregivers, and 17 perioperative healthcare providers were interviewed...
February 20, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28219667/mild-social-stress-in-mice-produces-opioid-mediated-analgesia-in-visceral-but-not-somatic-pain-states
#15
M H Pitcher, R Gonzalez-Cano, K Vincent, M Lehmann, E J Cobos, T J Coderre, J M Baeyens, F Cervero
Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in visceral versus somatic pain states, we studied the effects of a mild social stressor in either acute visceral or somatic pain states in mice. We show that the presence of an unfamiliar conspecific (stranger) in an adjacent cubicle of a standard transparent observation box produced elevated plasma corticosterone levels compared to mice tested alone, suggesting that the mere presence of a stranger is stressful...
February 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28196739/preschool-needle-pain-responding-establishing-normal
#16
Jordana A Waxman, Miranda G DiLorenzo, Rebecca R Pillai Riddell, David B Flora, Saul Greenberg, Hartley Garfield
The current study sets forth to provide both descriptive data for preschool vaccination pain responding and examine longitudinal relationships over early childhood. Growth mixture modeling (GMM) was first used to describe stable subgroups of preschoolers based on their pain response patterns over 2-minutes post-needle. Secondly, a parallel-process growth curve model was used to assess the stability of acute pain responding from 12-months of age to preschool age. Specifically, we examined whether preschool pain-related distress or regulation could be predicted from 12-month acute pain responding...
February 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28188907/safety-pharmacokinetic-and-pharmacodynamic-study-in-healthy-subjects-of-oral-neo6860-a-modality-selective-trpv1-antagonist
#17
William Brown, Richard L Leff, Andrew Griffin, Stuart Hossack, Roxane Aubray, Philippe Walker, Dan A Chiche
Most previous TRPV1 antagonist programs have been put on hold, mainly due on-target adverse events: hyperthermia and impaired noxious heat sensation. NEO6860 is a TRPV1 antagonist, blocking capsaicin activation of the target, with little or no effect against pH or heat activation. The hypothesis is that this pharmacological profile will translate into analgesia without undesired effects on the body temperature or heat-pain threshold. This phase I, double blind, placebo controlled, ascending dose study, included 64 subjects...
February 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28185925/modest-amounts-of-voluntary-exercise-reduce-pain-and-stress-related-outcomes-in-a-rat-model-of-persistent-hind-limb-inflammation
#18
Mark H Pitcher, Farid Tarum, Imran Z Rauf, Lucie A Low, Catherine Bushnell
Aerobic exercise improves outcomes in a variety of chronic health conditions, yet the support for exercise-induced effects on chronic pain in humans is mixed. Although many rodent studies have examined the effects of exercise on persistent hypersensitivity, the most used forced exercise paradigms that are known to be highly stressful. Because stress can also produce analgesic effects, we studied how voluntary exercise, known to reduce stress in healthy subjects, alters hypersensitivity, stress, and swelling in a rat model of persistent hind paw inflammation...
February 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28163234/what-s-in-a-name-the-case-of-emotional-disclosure-of-pain-related-distress
#19
Annmarie Cano, Liesbet Goubert
Pain behavior plays a key role in many theoretical models of pain, with many of these models conceptualizing pain behaviors as potentially detrimental to patient functioning. We propose that a certain class of behaviors-talking to others about one's pain-related distress (ie, emotional disclosures of pain-related distress)-can be distinguished from other behaviors traditionally conceptualized as pain behaviors. Emotional disclosures of pain-related distress include verbally disclosing one's anger, sadness, or worry about the pain and its effects to another person...
February 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161474/the-impact-of-parental-modeling-on-child-pain-responses-the-role-of-parent-and-child-sex
#20
Katelynn E Boerner, Christine T Chambers, Patrick J McGrath, Vincent LoLordo, Rudolf Uher
Social modeling is a process by which pain behaviours are learned, and research has found parents act as models for their children's behaviour. Despite social learning theory predicting that same-sex models have greater impact, no experimental investigation to date has examined the role of sex of the model or observer in social learning of pediatric pain. The present study recruited 168 parent-child dyads (equal father-son, father-daughter, mother-son, and mother-daughter dyads) where children were generally healthy 6- to 8-year-olds...
February 1, 2017: Journal of Pain: Official Journal of the American Pain Society
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