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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/30012494/randomized-trial-of-a-low-literacy-chronic-pain-self-management-program-analysis-of-secondary-pain-and-psychological-outcome-measures
#1
Barbara J Turner, Yuanyuan Liang, Natalia Rodriguez, Raudel Bobadilla, Maureen J Simmonds, Zenong Yin
Based on input of rural, largely Hispanic persons with chronic pain, a low literacy, 6-month self-management program was developed drawing upon elements of existing pain toolkits. In a randomized trial, low-income, primarily Hispanic patients with chronic pain received the program in 6 one-on-one meetings with a trained health educator in clinic or in 8 group lectures by experts in the community. Intention-to-treat (ITT) analyses in linear mixed effects models were conducted for five secondary outcomes at 6-months including: Brief Pain Inventory (BPI) pain severity and interference, Patient Health Questionnaire-9 (PHQ-9), 12-Item Short Form Survey Mental Component Summary (SF-12 MCS) and Tampa Scale for Kinesiophobia-11 (TSK-11)...
July 13, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/30006271/effects-of-different-parameters-of-continuous-training-and-high-intensity-interval-training-in-the-chronic-phase-of-mouse-model-of-complex-regional-pain-syndrome-type-i
#2
Luiz Augusto Oliveira Belmonte, Thiago César Martins, Daiana Cristina Salm, Aline Armiliato Emer, Bruna Hoffman de Oliveira, Khiany Mathias, Mariana Pereira Goldim, Verônica Vargas Horewicz, Anna Paula Piovezan, Franciane Bobinski, Fabrícia Petronilho, Daniel Fernandes Martins
This study evaluated the effects of continuous and interval running on treadmill on mechanical hyperalgesia in an animal model of chronic post-ischemia pain (CPIP), as well as to analyze the mechanism of action of this effect. Different groups of male Swiss mice with CPIP, induced by 3 hours of paw ischemia followed by reperfusion (IR), ran on the treadmill in different protocols, the speed (10, 13, 16 or 19 m/min), duration (15, 30 or 60 minutes), weekly frequency (3 or 5 times), weekly increase in continuous and interval running speed, were tested...
July 10, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/30004021/the-effect-of-pain-on-major-cognitive-impairment-in-older-adults
#3
Guusje van der Leeuw, Emmeline Ayers, Suzanne G Leveille, Annette H Blankenstein, Henriette E van der Horst, Joe Verghese
Older adults frequently report pain; cross-sectional studies have shown that pain is associated with worse cognitive function. However, longitudinal studies are lacking. We prospectively studied 441 participants without dementia, including 285 with pain, aged 65 years and older, enrolled in the Central Control of Mobility in Aging Study, a prospective cohort study. We analyzed the longitudinal association between pain (Medical Outcomes Study pain severity scale) and major cognitive impairment (Repeatable Battery for the Assessment of Neuropsychological Status and the Trail Making Test Delta) using Cox regression analysis adjusted for age, gender, ethnicity and education...
July 9, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29981376/acupuncture-resolves-persistent-pain-and-neuroinflammation-in-a-mouse-model-of-chronic-overlapping-pain-conditions
#4
Seungtae Kim, Xin Zhang, Sandra C O'Buckley, Mary Cooter, Jongbae J Park, Andrea G Nackley
Patients with chronic overlapping pain conditions have decreased levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Consistent with clinical syndromes, we previously demonstrated that COMT inhibition in rodents produces persistent pain and heightened immune responses. Here, we sought to determine the efficacy of manual acupuncture in resolving persistent pain and neuroinflammation in the classic inbred C57BL/6 strain and the 'rapid healing' MRL/MpJ strain. Mice received subcutaneous osmotic minipumps to deliver the COMT inhibitor OR486 or vehicle for 13 days...
July 4, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29969726/establishing-a-research-agenda-on-mobile-health-technologies-and-later-life-pain-using-an-evidence-based-consensus-workshop-approach
#5
Elaine Wethington, Christopher Eccleston, Geri Gay, Rachael Gooberman-Hill, Patricia Schofield, Elizabeth Bacon, Wen Dombrowski, Robert Jamison, Max Rothman, Lauren Meador, Cara Kenien, Karl Pillemer, Corinna Löckenhoff, M Carrington Reid
The rapid growth of mHealth devices holds substantial potential for improving care and care outcomes in all patient populations, including older adults with pain. However, existing research reflects a substantial gap in knowledge about how to design, evaluate, and disseminate devices to optimally address the many challenges associated with managing pain in older persons. Given these knowledge gaps, we sought to develop a set of practice-based research priorities to facilitate innovation in this field. We employed the Cornell Research-to-Practice Consensus Workshop Model, an evidence-based approach to generating research priorities...
June 30, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29966772/persistent-post-mastectomy-pain-current-status-and-future-directions
#6
REVIEW
Raymond C Tait, Kim Zoberi, McKenzie Ferguson, Kimberly Levenhagen, Rebecca A Luebbert, Kevin Rowland, Gretchen B Salsich, Christopher Herndon
Persistent Post-Mastectomy Pain (PPMP) is a common condition that can follow surgeries for breast cancer, the most common cancer for women. Because of the frequency of PPMP and its potential severity, it has received increasing research attention in recent years. This manuscript reviews the recent research literature. It begins with a brief history and data bearing on its prevalence. It then reviews medical, surgical, demographic, and psychosocial risk factors that have been identified, as well associal, psychological, and functional sequelae that have been linked to PPMP...
June 29, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29966771/psychological-factors-associated-with-ultra-marathon-runners-supra-normal-pain-tolerance-a-pilot-study
#7
Roebuck G S, Urquhart D M, Knox L, Fitzgerald P B, Cicuttini F M, Lee S, Fitzgibbon B M
Athletes appear to have higher pain tolerance than the normally active population. It is unknown whether psychological factors contribute to their supra-normal pain tolerance. The aim of this pilot study was to examine pain-related psychological processes in ultra-marathon runners ('ultra-runners') and to explore whether psychological factors mediate the elevated pain tolerance displayed by ultra-runners. Forty participants took part in the study: 20 ultra-runners and 20 age- and gender-matched controls. Participants underwent the cold pressor test (CPT) using water cooled to 0...
June 29, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29964216/nociceptive-and-cognitive-changes-in-a-murine-model-of-polytrauma
#8
Peyman Sahbaie, Maral Tajerian, Phillip Yang, Karen Amanda Irvine, Ting-Ting Huang, Jian Luo, Tony Wyss-Coray, J David Clark
POLYTRAUMA COMMONLY INVOLVES CONCUSSION (MILD TRAUMATIC BRAIN INJURY: mTBI) and peripheral trauma including limb fractures. Interactions between mTBI and peripheral injuries are poorly understood, both leading to chronic pain and neurobehavioral impairments. To elucidate these interactions, a murine polytrauma model was developed. mTBI alone resulted in similar increased mechanical allodynia in males and females. Female fracture and polytrauma groups displayed greater increases in hindpaw tactile hypersensitivity for weeks after injury than respective male groups...
June 28, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29949780/physical-and-psychosocial-factors-in-the-prevention-of-chronic-pain-in-older-age
#9
D Fancourt, A Steptoe
Chronic pain is recognised as a major challenge as people age. Yet, despite growing research on chronic pain management, there is little research into chronic pain prevention. So there is a clear need to identify multimodal activities that could be encouraged amongst older adults as part of a healthy lifestyle to reduce the incidence risk of chronic pain. Using data from the English Longitudinal Study of Ageing we tracked 2,631 adults aged 50+ who were free from chronic pain at baseline across a decade and explore whether physical or psychosocial factors reduced the risk of developing chronic pain...
June 24, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29920331/preoperative-neuropathic-pain-like-symptoms-and-central-pain-mechanisms-in-knee-osteoarthritis-predicts-poor-outcome-6-months-after-total-knee-replacement-surgery
#10
Thomas Kurien, Lars Arendt-Nielsen, Kristian K Petersen, Thomas Graven-Nielsen, Brigitte E Scammell
Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain symptoms and pain sensitisation. OA patients were pain phenotyped into two groups based on the PainDETECT questionnaire: High PainDETECT group (scores ≥19) indicating neuropathic pain-like symptoms, Low PainDETECT group (scores <19) indicating nociceptive or mixed pain...
June 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29890298/exploring-the-role-of-negative-cognitions-in-the-relationship-between-ethnicity-sleep-and-pain-in-women-with-temporomandibular-joint-disorder
#11
Sheera F Lerman, Claudia M Campbell, Luis F Buenaver, Mary Medak, Jane Phillips, Michelle Polley, Michael T Smith, Jennifer A Haythornthwaite
Negative cognitions are central to the perpetuation of chronic pain and sleep disturbances. Patients with temporomandibular joint disorder (TMJD), a chronic pain condition characterized by pain and limitation in the jaw area, have a high comorbidity of sleep disturbances that possibly exacerbate their condition. Ethnic group differences are documented in pain, sleep and coping, yet the mechanisms driving these differences are still unclear, especially in clinical pain populations. 156 women (79% white, 21% African American (AA)) diagnosed with TMJD were recruited as part of a randomized controlled trial evaluating the effectiveness of interventions targeting sleep and pain catastrophizing on pain in TMJD...
June 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29890297/nociception-pain-consciousness-and-society-a-plea-for-constrained-use-of-pain-related-terminologies
#12
A Vania Apkarian
This focus article addresses the issue of the proper use of terminology in pain research. A review and some revisions on the definitions of pain and nociception, in relation to consciousness is presented. From a behavioral viewpoint, it is argued that pain is a conscious assessment of the failure of the organism to protect the body from injury (actual or potential); while continuously-ongoing sub/pre-conscious nociceptive processes protect the body from injuries. Thus, pain perception/behavior requires a subjective ability to evaluate the environment and form coordinated responses...
June 8, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29885369/the-relationship-of-endocannabinoidome-lipid-mediators-with-pain-and-psychological-stress-in-women-with-fibromyalgia-a-case-control-study
#13
Niclas Stensson, Nazdar Ghafouri, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Björn Gerdle, Bijar Ghafouri
Characterized by chronic widespread pain, generalized hyperalgesia, and psychological stress fibromyalgia (FM) is difficult to diagnose and lacks effective treatments. The endocannabinoids - arachidonoylethanolamide (AEA), 2-arachidonoylglycerol (2-AG), and the related oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and stearoylethanolamide (SEA) - are endogenous lipid mediators with analgesic and anti-inflammatory characteristics, in company with psychological modulating properties (e.g., stress and anxiety), and are included in a new emerging "ome", the endocannabinoidome...
June 6, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29758355/alcohol-and-opioid-use-in-chronic-pain-a-cross-sectional-examination-of-differences-in-functioning-based-on-misuse-status
#14
Kevin E Vowles, Katie Witkiewitz, Melissa Pielech, Karlyn A Edwards, Mindy L McEntee, Robert W Bailey, Lena Bolling, Mark D Sullivan
Opioid misuse is regularly associated with disrupted functioning in those with chronic pain. Less work has examined whether alcohol misuse may also interfere with functioning. This study examined frequency of opioid and alcohol misuse in 131 individuals (61.1% female) prescribed opioids for the treatment of chronic pain. Participants completed an anonymous survey online, consisting of measures of pain, functioning, and opioid and alcohol misuse. Cut scores were used to categorize individuals according to substance misuse status...
June 4, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29864506/spouse-criticism-hostility-toward-partners-with-chronic-pain-the-role-of-spouse-attributions-for-patient-control-over-pain-behaviors
#15
John W Burns, James Gerhart, Kristina M Post, David A Smith, Laura S Porter, Asokumar Buvanendran, Anne Marie Fras, Francis J Keefe
Spouse attributions regarding displays of pain behaviors by their partners with chronic pain may account for subsequent increases in spouse critical/hostile responses toward their partners. People with chronic low back pain (n = 105) and their pain-free spouses (n = 105) completed electronic diary measures five times per day for 14 consecutive days. Key items assessed spouse observations of patient pain behavior, attributions regarding these behaviors, and spouse critical/hostile responses toward patients...
June 1, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29803671/cortical-somatosensory-excitability-is-modulated-in-response-to-several-days-of-muscle-soreness
#16
Enrico DE Martino, Laura Petrini, Siobhan Schabrun, Thomas Graven-Nielsen
Changes in excitability of the sensorimotor cortex have been demonstrated in clinical musculoskeletal pain although the timing is unknown. Eccentric exercise provokes delayed onset muscle soreness providing a model to study the temporal profile of sensorimotor cortical plasticity during progressively developing muscle soreness. Twelve healthy subjects performed eccentric exercise of the wrist extensors. Likert pain scores, pressure pain thresholds (PPTs) at the extensor carpi radialis (ECR) muscle, somatosensory evoked potentials from electrical stimulation of the radial nerve, maximal wrist extension force, and ECR motor evoked potentials (MEPs) to transcranial magnetic stimulation were recorded before (Baseline), 2-h (2-h Post), 2-days (Day2), and 6-days (Day6) after exercise...
May 24, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29803670/intrinsic-activity-of-c57bl-6-substrains-associates-with-high-fat-diet-induced-mechanical-sensitivity-in-mice
#17
Michael A Cooper, Bryn O'Meara, Megan M Jack, Dan Elliot, Bradley Lamb, Zair W Khan, Blaise W Menta, Janelle M Ryals, Michelle K Winter, Douglas E Wright
Pain is significantly impacted by the rising epidemic of obesity and metabolic syndrome. Our understanding of how these features impact pain is only beginning to be developed. Here, we investigated how small genetic differences among C57BL/6 mice from two different commercial vendors leads to important differences in the development of high-fat diet-induced mechanical sensitivity. Two sub strains of C57BL/6 mice from Jackson laboratories (C57BL/6J and C57BL/6NIH), as well as C57BL/6 from Charles Rivers (C57BL/6CR) were placed on high-fat diets and analyzed for changes in metabolic features influenced by high-fat diet and obesity, as well as measures of pain related behaviors...
May 24, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29803669/the-use-of-adjunct-psychosocial-interventions-can-decrease-postoperative-pain-and-improve-the-quality-of-clinical-care-in-orthopedic-surgery-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#18
REVIEW
Csenge Szeverenyi, Zoltan Kekecs, Alisa Johnson, Gary Elkins, Zoltan Csernatony, Katalin Varga
The present study aims to assess the effectiveness of psychosocial techniques to decrease postoperative pain and improve perioperative clinical care in orthopedic surgery. A systematic review and meta-analysis was performed to evaluate the effects of psychosocial methods among adults undergoing orthopedic surgeries. The systematic review included both randomized and non-randomized trials, but only randomized controlled clinical trials (RCTs) were included in the meta-analysis. Key outcomes were postoperative pain, analgesic requirement, perioperative anxiety, quality of life, and recovery...
May 24, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777951/experimental-referred-pain-extends-toward-previously-injured-location-an-explorative-study
#19
Thorvaldur Skuli Palsson, Shellie A Boudreau, Hans Jørgen Krebs, Thomas Graven-Nielsen
Facilitated pain mechanisms have been demonstrated in musculoskeletal pain, but it is unclear whether a recent painful injury leaves the pain system sensitized. Pain characteristics were assessed in individuals who recently recovered from ankle pain (recovered pain group; n = 25) and sex-matched control subjects (n = 25) in response to tonic pressure pain and saline-induced pain applied at the shin muscle. Pain intensity and pain referral patterns were recorded bilaterally after the painful muscle stimulus...
May 17, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777954/parent-responses-to-child-pain-during-intensive-interdisciplinary-pain-treatment-and-1-year-follow-up-%C3%A2-%C3%A2-%C3%A2
#20
Melissa Pielech, Dustin P Wallace, Megan Fitzgerald, Cara M Hoffart
Targeting parents' responses to their child's pain during intensive interdisciplinary pain treatment (IIPT) could influence child functioning. This longitudinal, observational study investigated changes in these responses and concurrent relationships between parent responses and changes in levels of child functioning and pain. Parents of youth age 10-19 years (M=15, SD=1.98) participated in twice weekly, parent-only groups while their teens were enrolled in IIPT (mean length of treatment 3.93 weeks, SD=1.16)...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
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