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Journal of Pain: Official Journal of the American Pain Society

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https://www.readbyqxmd.com/read/28428093/migraine-prevention-using-different-frequencies-of-transcutaneous-occipital-nerve-stimulation-a-randomized-controlled-trial
#1
Yinglu Liu, Zhao Dong, Rongfei Wang, Ran Ao, Xun Han, Wenjing Tang, Shengyuan Yu
OBJECTIVE: To evaluate the efficacy and tolerability of transcutaneous occipital nerve stimulation (tONS) in patients with migraine, and to explore whether different tONS frequencies influenced treatment effectiveness. METHODS: This was a randomized, controlled trial of tONS for prevention of migraine. Patients were randomized to one of five therapeutic groups prior to treatment for 1 month. Groups A-C received tONS at different frequencies (2 Hz, 100 Hz, and 2/100 Hz), group D underwent sham tONS intervention, and group E received topiramate orally...
April 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28428092/validation-of-the-pain-resilience-scale-in-a-chronic-pain-sample
#2
Brett Ankawi, P Maxwell Slepian, Lina K Himawan, Christopher R France
Psychosocial factors that protect against negative outcomes for individuals with chronic pain have received increased attention in recent years. Pain resilience, or the ability to maintain behavioral engagement and regulate emotions as well as cognitions despite prolonged or intense pain, is one such factor. A measure of pain-specific resilience, the Pain Resilience Scale, was previously identified as a better predictor of acute pain tolerance than general resilience. The present study sought to validate this measure in a chronic pain sample, while also furthering understanding of the role of pain resilience when compared to other protective factors...
April 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28428091/characterization-of-the-effects-of-l-4-chlorokynurenine-on-nociception-in-rodents
#3
Tony L Yaksh, Robert Schwarcz, H Ralph Snodgrass
Upon systemic administration in rats, the prodrug L-4-chlorokynurenine (4-Cl-KYN) (AV-101) is rapidly absorbed, actively transported across the blood-brain barrier, and converted in astrocytes to 7-chlorokynurenic acid (7-Cl-KYNA), a potent and specific antagonist of the GlyB co-agonist site of the NMDA receptor. We examined the effects of 4-Cl-KYN in several rat models of hyperalgesia and allodynia and determined the concentrations of 4-Cl-KYN and newly produced 7-Cl-KYNA in serum, brain and spinal cord. Adult male rats were given 4-Cl-KYN (56, 167, 500 mg/kg), the NMDA receptor antagonist MK-801 (0...
April 17, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28412229/characteristics-and-factors-associated-with-pain-in-older-homeless-individuals-results-from-the-hope-home-study
#4
John C Landefeld, Christine Miaskowski, Lina Tieu, Claudia Ponath, Christopher T Lee, David Guzman, Margot Kushel
Individuals experiencing homelessness in the United States are aging; little is known about chronic pain in this population. In a cross-sectional, population-based study, we interviewed 350 homeless individuals aged 50 and older to describe pain experienced by older persons experiencing homelessness and to assess factors associated with chronic moderate to severe pain, defined as pain lasting ≥3 months, with a past week average severity score of 5-10 (scale 0-10). The median age of participants was 58 years...
April 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28400293/the-dorsolateral-prefrontal-cortex-in-acute-and-chronic-pain
#5
David A Seminowicz, Massieh Moayedi
The dorsolateral prefrontal cortex (DLPFC) is a functionally and structurally heterogeneous region and a key node of several brain networks, implicated in cognitive, affective, and sensory processing. As such, the DLPFC is commonly activated in experimental pain studies, and shows abnormally increased function in chronic pain populations. Furthermore, several studies have shown that some chronic pains are associated with decreased left DLPFC gray matter and that successful interventions can reverse this structural abnormality...
April 8, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28396046/minocycline-prevents-muscular-pain-hypersensitivity-and-cutaneous-allodynia-produced-by-repeated-intramuscular-injections-of-hypertonic-saline-in-healthy-human-participants
#6
Mohamad Samir Samour, Saad Saulat Nagi, Peter John Shortland, David Anthony Mahns
Minocycline, a glial suppressor, prevents behavioural hypersensitivities in animal models of peripheral nerve injury. However clinical trials of minocycline in human studies have produced mixed results. This study addressed two questions: can repeated injections of hypertonic saline (HS) in humans induce persistent hypersensitivity? Can pre-treatment with minocycline, a tetracycline antibiotic with microglial inhibitory effects, prevent the onset of hypersensitivity? Twenty seven healthy participants took part in this double-blind, placebo-controlled study, consisting of six test sessions across 2 weeks...
April 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28385510/classical-conditioning-differences-associated-with-chronic-pain-a-systematic-review
#7
REVIEW
Daniel S Harvie, G Lorimer Moseley, Susan L Hillier, Ann Meulders
Prominent clinical models of chronic pain propose a fundamental role of classical conditioning in the development of pain-related disability. If classical conditioning is key to this process, then people with chronic pain may show a different response to pain-related conditioned stimuli (CS) than healthy controls. We set out to determine whether this is the case by undertaking a comprehensive and systematic review of the literature. To identify studies comparing classical conditioning between people with chronic pain and healthy controls, the databases MEDLINE, PsychINFO, PsychARTICLES, Scopus, CINAHL, were searched using key words and MESH headings consistent with 'classical conditioning' AND 'pain'...
April 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28365372/endogenous-opioid-function-and-responses-to-morphine-the-moderating-effects-of-anger-expressiveness
#8
John W Burns, Stephen Bruehl, Christopher R France, Erik Schuster, Daria Orlowska, Melissa Chont, Rajnish K Gupta, Asokumar Buvanendran
Long-term use of opioid analgesics may be ineffective or associated with significant negative side effects for some people. At present, there is no sound method of identifying optimal opioid candidates. Individuals with chronic low back pain (n=89) and healthy controls (n=102) underwent ischemic pain induction under placebo, opioid blockade (naloxone), and morphine in counterbalanced order. They completed the Spielberger Anger-out subscale. Endogenous opioid function x anger-out x pain status (chronic pain; healthy control) interactions were tested for morphine responses to ischemic threshold, tolerance and pain intensity (McGill Sensory and Affective subscales) and side effects...
March 29, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28363861/prevalence-and-predictors-of-chronic-postsurgical-pain-in-children-a-systematic-review-and-meta-analysis
#9
REVIEW
Jennifer A Rabbitts, Emma Fisher, Brittany N Rosenbloom, Tonya M Palermo
Emerging research suggests that pain may persist longer-term for many children after major surgery, with significant impact on their health outcomes. This systematic review identified the prevalence of chronic postsurgical pain (CPSP) in children after surgery, and determined presurgical biomedical and psychosocial risk factors associated with CPSP prevalence or severity. Prospective studies assessing CPSP 3-12 months after surgery in children 6-18 years of age published in English in MEDLINE, EMBASE, PsycINFO, and Cochrane Database of Systematic Reviews since 1996 were eligible for inclusion...
March 28, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28347798/predictors-of-prescription-opioid-use-4-months-after-traumatic-musculoskeletal-injury-and-corrective-surgery-a-prospective-study
#10
Brittany N Rosenbloom, Colin J L McCartney, Sonya Canzian, Hans J Kreder, Joel Katz
The aim of the present study was to examine the incidence and predictors of persistent prescription opioid use 4-months after traumatic injury. Adults who sustained a traumatic musculoskeletal injury were recruited to participate in this observational prospective, longitudinal study within 14 days of injury (T1) and followed for 4-months (T2). Measures included questionnaires on pain, opioid consumption, pain disability, anxiety, depression, and posttraumatic stress symptoms as well as a chart review for injury related information...
March 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28347797/twin-peaks-no-evidence-of-bimodal-distribution-of-outcomes-in-clinical-trials-of-non-surgical-interventions-for-spinal-pain-an-exploratory-analysis
#11
Neil E O'Connell, Steven J Kamper, Matthew L Stevens, Qiang Li
OBJECTIVE: The presence of bimodal outcome distributions has been used as a justification for conducting responder analyses, in addition to, or in place of analyses of mean difference, in clinical trials and systematic reviews of interventions for pain. The aim of this study was to investigate the distribution of participants' pain outcomes for evidence of bimodal distribution. STUDY DESIGN AND SETTING: We sourced data on participant outcomes from a convenience sample of 10 trials of non-surgical interventions (exercise, manual therapy, medication) for spinal pain...
March 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28347796/systematic-review-of-self-report-measures-of-pain-intensity-in-3-and-4-year-olds-bridging-a-period-of-rapid-cognitive-development
#12
REVIEW
Carl L von Baeyer, Tiina Jaaniste, Henry L T Vo, Georgie Brunsdon, Amy Hsuan-Chih Lao, G David Champion
Claims are made for the validity of some self-report pain scales for 3- and 4-year-old children, but little is known about their ability to use such tools. This systematic review identified self-report pain intensity measures used with 3- and/or 4- year-old participants (3-4yo) and considered their reliability and validity within this age span. The search protocol identified research articles that included 3-4yo, reported use of any pain scale, and included self-reported pain intensity ratings. A total of 1,590 articles were screened and 617 articles met inclusion criteria...
March 24, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28344101/predictors-of-acute-post-surgical-pain-following-inguinal-hernioplasty
#13
Patrícia R Pinto, Artur Vieira, Diamantino Pereira, Armando Almeida
Acute post-surgical pain (APSP) is a common and anticipated problem after surgery with detrimental consequences if not appropriately managed. This study examined the independent and joint contribution of pre-surgical demographic, clinical and psychological variables as predictors of APSP intensity, evaluated through an 11-point numerical rating scale, after inguinal hernioplasty, one of the most performed surgeries worldwide. In a prospective observational cohort study, a consecutive sample of 135 men undergoing hernioplasty was assessed before (T1) and 48 hours after (T2) surgery...
March 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28344100/facilitated-pro-nociceptive-pain-mechanisms-in-radiating-back-pain-compared-with-localized-back-pain
#14
Henrik Bjarke Vaegter, Thorvaldur Skuli Palsson, Thomas Graven-Nielsen
Facilitated pain mechanisms and impaired pain inhibition are often found in chronic pain patients. This study compared clinical pain profiles, pain sensitivity, as well as pro-nociceptive and anti-nociceptive mechanisms in patients with localized low back pain (n=18), localized neck pain (n=17), low back and radiating leg pain (n=18), or neck and radiating arm pain (n=17). It was hypothesized that patients with radiating pain had facilitated pain mechanisms and impaired pain inhibition compared with localized pain patients...
March 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28342891/cost-utility-of-group-acceptance-and-commitment-therapy-for-fibromyalgia-versus-recommended-drugs-an-economic-analysis-alongside-a-6-month-randomised-controlled-trial-conducted-in-spain-effigact-study
#15
Juan V Luciano, Francesco D'Amico, Albert Feliu-Soler, Lance M McCracken, Jaume Aguado, María T Peñarrubia-María, Martin Knapp, Antoni Serrano-Blanco, Javier García-Campayo
The aim of this study was to analyse the cost-utility of a group-based form of Acceptance and Commitment Therapy (GACT) in patients with fibromyalgia (FM) compared to patients receiving recommended pharmacological treatment (RPT) or on a waiting list (WL). The data were derived from a previously published study, an RCT that focused on clinical outcomes. Health economic outcomes included health-related quality of life and healthcare use at baseline and at 6-month follow-up using the EuroQol (EQ-5D-3L) and the Client Service Receipt Inventory (CSRI), respectively...
March 22, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28323246/the-role-of-spinal-gabab-receptors-in-cancelr-induced-bone-pain-in-rats
#16
Ya-Qun Zhou, Shu-Ping Chen, Dai-Qiang Liu, Anne Manyande, Wen Zhang, Shao-Bing Yang, Bing-Rui Xiong, Qiao-Chu Fu, Zhen-Peng Song, Heike Rittner, Da-Wei Ye, Yu-Ke Tian
Cancer-induced bone pain (CIBP) remains a major challenge in advanced cancer patients due to our lack of understanding of its mechanisms. Previous studies have demonstrated the vital role of GABAB receptors (GABABRs) in regulating nociception and various neuropathic pain models have shown diminished activity of GABABRs. However, the role of spinal GABABRs in CIBP remains largely unknown. In this study, we investigated the specific cellular mechanisms of GABABRs in the development and maintenance of CIBP in rats...
March 18, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28300651/sleep-fragmentation-hypersensitizes-healthy-young-women-to-deep-and-superficial-experimental-pain
#17
Stella Iacovides, Kezia George, Peter Kamerman, Fiona C Baker
The effect of sleep deprivation on pain sensitivity has typically been studied using total and partial sleep deprivation protocols. These protocols do not mimic the fragmented pattern of sleep disruption usually observed in individuals with clinical pain conditions. Therefore, we conducted a controlled experiment to investigate the effect of sleep fragmentation on pain perception (deep pain: forearm muscle ischemia, and superficial pain: graded pin pricks applied to the skin) in 11 healthy young women after 2 consecutive nights of sleep fragmentation, compared with a normal night of sleep...
March 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28300650/painful-after-sensations-in-fibromyalgia-are-linked-to-catastrophizing-and-differences-in-brain-response-in-the-medial-temporal-lobe
#18
Kristin L Schreiber, Marco L Loggia, Jieun Kim, Christine M Cahalan, Vitaly Napadow, Robert R Edwards
Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain, hyperalgesia, and other disabling symptoms. While the brain response to experimental pain in FM patients has been the object of intense investigation, the biological underpinnings of painful after-sensations (PAS), and their relation to negative affect have received little attention. In this cross-sectional cohort study, subjects with FM (n=53) and healthy controls (n=17) were assessed for PAS by exposure to a sustained, moderately painful cuff stimulus to the leg, individually calibrated to a target pain intensity of 40/100...
March 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28279705/lower-placebo-responses-after-long-term-exposure-to-fibromyalgia-pain
#19
Eva Kosek, Annelie Rosen, Serena Carville, Ernest Choy, Richard H Gracely, Hanke Marcus, Frank Petzke, Martin Ingvar, Karin B Jensen
Knowledge about placebo mechanisms in patients with chronic pain is scarce. Fibromyalgia syndrome (FM) is associated with dysfunctions of central pain inhibition, and since placebo analgesia entails activation of endogenous pain inhibition, we hypothesized that long-term exposure to FM pain would negatively affect placebo responses. Here we examined the placebo-group (n=37, mean age 45 years) from a 12-week, randomized, double-blind, placebo-controlled trial investigating the effects of milnacipran or placebo...
March 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28279704/beliefs-about-pharmaceutical-medicines-and-natural-remedies-explain-individual-variation-in-placebo-analgesia
#20
Andrew Watkinson, Sarah C E Chapman, Rob Horne
This study examined whether placebo responses were predicted by a theoretical model of specific and general treatment beliefs. Using a randomised cross-over, experimental design (168 healthy individuals) we assessed whether responses to a cold pressor task were influenced by two placebo creams described as Pharmaceutical vs Natural origin. We assessed whether placebo responses were predicted by pre-treatment beliefs about the treatments (placebo) and by beliefs about the pain. The efficacy of both Pharmaceutical and Natural Placebos in reducing Pain Intensity was predicted by aspects of pain catastrophizing including Feelings of Helplessness (Pharmaceutical: B=0...
March 6, 2017: Journal of Pain: Official Journal of the American Pain Society
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