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Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

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https://www.readbyqxmd.com/read/30413661/f-18-fdg-pet-ct-for-monitoring-of-ipilimumab-therapy-in-patients-with-metastatic-melanoma
#1
Kimiteru Ito, Rebecca Teng, Heiko Schöder, John L Humm, Ai Ni, Laure Michaud, Reiko Nakajima, Rikiya Yamashita, Jedd D Wolchok, Wolfgang A Weber
Immune checkpoint inhibitors (ICIs) are now commonly used to treat patients with metastatic malignant melanoma. While concerns have been raised that the inflammatory response induced by ICIs may limit the ability of 18 F-FDG PET/CT to assess tumor response, systematic analyses on the use of 18 F-FDG PET/CT in this setting are mostly lacking. Thus, we set out to evaluate the association between tumor response on 18 F-FDG PET/CT and prognosis in patients with metastatic malignant melanoma treated with ipilimumab...
November 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30413660/a-single-dose-of-225-ac-rps-074-induces-a-complete-tumor-response-in-a-lncap-xenograft-model
#2
James M Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Nikki A Thiele, David Schlyer, Justin J Wilson, Stephen G DiMagno, John W Babich
Promising biochemical responses to 225 Ac-PSMA-617, even in patients that are refractory to beta-particle radiation, illustrate the potential of targeted alpha therapy (TAT) for the treatment of metastatic castrate-resistant prostate cancer. However, side effects such as xerostomia are severe and irreversible. In order to fully harness the potential of TAT, it is necessary to increase the therapeutic index of the targeted radioligands. One emerging strategy is to Increase clearance half-life through enhanced binding to serum albumin...
November 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30413659/nuclear-medicine-board-review-questions-and-answers-for-self-assessment-4th-edition
#3
Mark Youssef, Robert Matthews
No abstract text is available yet for this article.
November 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30413658/metabolic-subtyping-of-pheochromocytoma-and-paraganglioma-by-18-f-fdg-pharmacokinetics-using-dynamic-pet-ct-scanning
#4
Anouk van Berkel, Dennis Vriens, Eric Visser, Marcel Janssen, Martin Gotthardt, Ad Hermus, Lioe-Fee de Geus-Oei, Henri Timmers
Background: Static single timeframe 18 F-FDG PET/CT is useful for the localization and functional characterization of pheochromocytoma and paraganglioma (PPGL). 18 F-FDG-uptake varies between PPGLs with different genotypes and highest standardized uptake values (SUVs) are observed in case of succinate dehydrogenase (SDH) mutations, possibly related to enhanced aerobic glycolysis in tumor cells. The exact determinants of 18 F-FDG accumulation in PPGL are unknown. We performed dynamic PET/CT scanning to assess in vivo 18 F-FDG pharmacokinetics to investigate whether it has added value over static PET to distinguish different genotypes...
November 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30413657/immuno-pet-of-innate-immune-markers-cd11b-and-il-1%C3%AE-detect-inflammation-in-murine-colitis
#5
Nicole Dmochowska, William Tieu, Marianne Keller, Hannah Wardill, Chris Mavrangelos, Melissa Campaniello, Prab Takhar, Patrick A Hughes
Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. The diagnosis and monitoring of IBD is reliant on endoscopy which is invasive and does not provide information regarding specific mediators. Symptom flare in IBD is associated with increased activation of innate immune pathways. Immuno-PET approaches have previously demonstrated the ability to detect colitis, however direct comparison of antibodies targeted to innate immune mediators and cells have not been evaluated...
November 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30413656/role-of-18-f-fdg-pet-ct-in-cardiac-sarcoid-detection-and-therapy-monitoring-addition-to-the-expert-consensus
#6
Yang Lu, Nadera Sweiss
No abstract text is available yet for this article.
November 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389825/principal-component-analysis-of-brain-metabolism-predicts-development-of-alzheimer-s-dementia
#7
Ganna Blazhenets, Yilong Ma, Arnd Sörensen, Gerta Rücker, Florian Schiller, David Eidelberg, Lars Frings, Philipp T Meyer
The predictive value of 18 F-fluorodeoxyglucose (FDG) PET for conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) is currently under debate. We used a principal component analysis (PCA) to identify a metabolic AD conversion-related pattern (ADCRP) and investigated the prognostic value of the resulting pattern expression score (PES). Methods: FDG PET scans of 544 MCI patients obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were analyzed. We implemented voxel-based PCA and standard SPM (as reference) analyses to disclose cerebral metabolic patterns associated with conversion from MCI to AD...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389824/variability-and-repeatability-of-quantitative-uptake-metrics-in-18-f-fdg-pet-ct-imaging-of-non-small-cell-lung-cancer-impact-of-segmentation-method-uptake-interval-and-reconstruction-protocol
#8
Mingzan Zhuang, David Vállez García, Gerbrand Maria Kramer, Virginie Frings, E F Smit, Rudi A Dierckx, Otto S Hoekstra, Ronald Boellaard
OBJECTIVES: There is increased interest in various new quantitative uptake metrics beyond standardized uptake value (SUV) in oncology PET/CT studies. The purpose of this study is to investigate the variability and test-retest repeatability (TRT) of metabolically active tumor volume (MATV) measurements and several other new quantitative metrics in non-small cell lung cancer (NSCLC) using [18 F]FDG PET/CT with different segmentation methods, user interactions, uptake intervals, and reconstruction protocols. METHODS: Ten advanced NSCLC patients received two whole-body [18 F]FDG PET/CT scans at both 60 and 90 min post-injection...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389823/discovery-of-18-f-psma-7-a-novel-pet-probe-for-the-detection-of-small-psma-positive-lesions
#9
Boris D Zlatopolskiy, Heike Endepols, Philipp Krapf, Mehrab Guliyev, Elizaveta A Urusova, Raphael Richarz, Melanie Hohberg, Markus Dietlein, Alexander E Drzezga, Bernd Neumaier
Prostate specific membrane antigen (PSMA) expressed by the vast majority of prostate cancers (PCa) is a promising target for PCa imaging. The application of PSMA specific 18 F-labeled PET probes like 18 F-DCFPyL and 18 F-PSMA-1007 considerably improved the accuracy of PCa tumor detection. However, there remains a need for further improvements regarding sensitivity and specificity. The aim of this study was the development of highly selective and specific PSMA probes with enhanced imaging properties, in comparison with 18 F-DCFPyL, 18 F-PSMA-1007 and 68 Ga-PSMA-11...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389822/pet-imaging-of-parp-expression-using-18-f-olaparib
#10
Thomas Wilson, Mary-Ann Xavier, James Knight, Stefan Verhoog, Julia Baguña Torres, Michael Mosley, Samantha Hopkins, Sheena Wallington, Danny Allen, Veerle Kersemans, Rebekka Hueting, Sean Smart, Veronique Gouverneur, Bart Cornelissen
PARP inhibitors are increasingly being studied as cancer drugs, as single agents or as a part of combination therapies. Imaging of PARP using a radiolabeled inhibitor has been proposed for patient selection, outcome prediction, dose optimization, genotoxic therapy evaluation, and target engagement imaging of novel PARP-targeting agents. Here, via the copper-mediated 18 F-radiofluorination of aryl boronic esters, we accessed, for the first time, the 18 F-radiolabeled isotopologue of the Food and Drug Administration-approved PARP inhibitor olaparib...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389821/hexokinase-2-expression-in-met-positive-fdg-negative-multiple-myeloma
#11
Stefan Kircher, Antje Stolzenburg, Klaus Martin Kortuem, Malte Kircher, Matteo Da Via, Samuel Samnick, Andreas Buck, Hermann Einsele, Andreas Rosenwald, Constantin Lapa
Positron emission tomography (PET) with 18 F-fluorodeoxyglucose (18 F-FDG) is the standard modality in nuclear medicine for imaging multiple myeloma (MM). However, viable MM as detected by magnetic resonance imaging or PET with other metabolic tracers including 11 C-methionine (11 C-MET) may be missed by this technique, e.g. due to low hexokinase-2 expression of tumor cells. The aim of this study was to further investigate potential reasons for PET "false-negativity". Methods: A cohort of 15 mainly pre-treated, relapsed/refractory patients with biopsy-proven, serologically active MM who underwent both 18 F-FDG- and 11 C-MET-PET/CT was retrospectively analysed...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389820/optimized-feature-extraction-for-radiomics-analysis-of-18-f-fdg-pet-imaging
#12
Laszlo Papp, Ivo Rausch, Marko Grahovac, Marcus Hacker, Thomas Beyer
Radiomics analysis of 18 F-FDG-PET/CT images promises for an improved in-vivo disease characterization. To date, several studies reported significant variations in textural features due to differences in patient preparation, imaging protocols, lesion delineation and feature extraction. Our objective was to study variations of features prior to a radiomics analysis of 18 F-FDG-PET data and to identify those feature extraction and imaging protocol parameters that minimize radiomic feature variations across PET imaging systems...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389819/preserving-preclinical-pet-quality-during-intratherapeutic-imaging-in-radionuclide-therapy-with-rose-metal-shielding-reducing-photon-flux
#13
Emma Matilda Mellhammar, Magnus Dahlbom, Susan Evans-Axelsson, Sven-Erik Strand
Performing Positron Emission Tomography (PET) imaging intratherapeutically during ongoing radionuclide therapy, can be a promising method to follow tumor response in vivo. However, the high therapeutic activity can interfere with the PET camera performance and degrade both image quality and quantitative capabilities. As a solution, low energy photon emissions from the therapeutic radionuclide can be highly attenuated, still allowing sufficient detection of annihilation photons in coincidence. Methods: Hollow Rose metal cylinders with 2-4 mm walls were used to shield a 22 Na point source and a uniform phantom filled with 18 F as they were imaged on a pre-clinical PET camera with increasing activities of 177 Lu...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389818/assessment-of-myocardial-czt-spect-recording-in-a-forward-leaning-biker-like-position
#14
Mathieu Perrin, Véronique Roch, Marine Claudin, Antoine Verger, Henri Boutley, Gilles Karcher, Cédric Baumann, Nicolas Veran, Pierre-Yves Marie, Laetitia Imbert
Purpose: This prospective randomized study aimed at assessing myocardial perfusion imaging recorded with the high-sensitivity "D.SPECT" cadmium-zinc-telluride (CZT) camera in a forward-leaning "biker-like" position, which may potentially lower diaphragmatic attenuation as well as reduce breathing-related cardiac motions, in manner comparable to the prone position proposed with other SPECT cameras. Methods: Patients referred to a stress-rest 99m Tc-Sestamibi protocol and positioned in the "biker" position, with the chest leaning forward on the D...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389817/biodistribution-tumor-detection-and-radiation-dosimetry-of-f-18-5-fluoro-2-deoxycytidine-18-f-fdcyd-with-tetrahydrouridine-in-solid-tumors
#15
Colin R Young, Stephen Adler, Janet F Eary, M Liza Lindenberg, Paula M Jacobs, Jerry Collins, Shivaani Kummar, Karen A Kurdziel, Peter L Choyke, Esther Mena
In pre-clinical studies, 5-fluoro-2'-deoxycytidine (FdCyd), an inhibitor of DNA methyltransferase and DNA hypermethylation, has shown treatment efficacy against multiple malignancies by suppressing epigenetic hypermethylation in tumor cells. Several clinical trials are undergoing using FdCyd and while some patients may respond to this drug, in the majority of patients it is ineffective. Thus, by establishing a non-invasive imaging modality to evaluate the distribution of the drug may provide insight into the variable responses...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389816/dosimetry-estimate-and-initial-clinical-experience-with-90-y-psma-617
#16
Hendrik Rathke, Paul Flechsig, Walter Mier, Marcus Bronzel, Eleni Mavriopoulou, Manuel Roehrich, Markus Hohenfellner, Frederik L Giesel, Uwe L Haberkorn, Clemens Kratochwil
Due to different physical properties, the beta-emitters 177 Lu and 90 Y offer specific radiation-biological advantages in dedicated clinical situations, respectively. Our objective was to introduce 90 Y-PSMA-617 to clinical application, providing additional avenues for personalized medicine. Here we present our dosimetry-estimate for 90 Y-PSMA-617, report initial clinical experiences and discuss the advantages and drawbacks of varying the beta-emitter in prostate-specific membrane antigen (PSMA) targeting radioligand therapy (RLT)...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389815/an-international-survey-on-clinical-reporting-of-dual-modality-pet-ct-imaging-examinations-a-starting-point-for-cross-specialty-engagement
#17
Lutz S Freudenberg, Rodney J Hicks, Thomas Beyer
Introduction: Combined PET/CT imaging has become an integral part of patient management, particularly in oncology. Following the imaging examination, a report of the findings is created by the expert readers and sent to the referrers as a basis for subsequent management decision-making for their patients. In view of the known wide variation in operational models of PET/CT imaging, we initiated a survey of PET/CT users regarding their approaches towards PET/CT reporting. Materials and Methods: An electronic survey was composed with a set of 28 questions regarding the demographics and professional background of the survey responders, as well as questions regarding the structure and quality of PET/CT reports, including the type of reported information, the use of reporting standards and the mix of reporting and presenting experts...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30389814/assessment-of-ileocolonic-inflammation-in-crohn-s-disease-which-surrogate-marker-is-better-maria-clermont-or-pet-mr-index-initial-results-of-a-feasibility-trial
#18
Yan Li, Jost Langhorst, Anna Katharina Koch, Aydin Demircioglu, Felix Nensa, Julian Kirchner, Karsten Beiderwellen, Onofrio Catalano, Michael Forsting, Ken Herrmann, Lale Umutlu
Rationale: To define an [18 F]-FDG PET/MR enterography index as a hybrid surrogate marker for active ileocolonic inflammation in Crohn's disease (CD) and assess its diagnostic performance in comparison to validated MR indices (MaRIA, Clermont score). Methods: 52 CD patients with recurrent symptoms underwent ileocolonoscopy and [18 F]-FDG PET/MR enterography. 303 ileocolonic segments were analyzed for assessment of inflammation utilizing the MaRIA and Clermont score as well as the newly defined PET-MR index...
November 2, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30361382/performance-evaluation-of-the-philips-vereos-pet-ct-system-according-to-the-nema-nu2-2012-standard
#19
Ivo Rausch, Agustin Ruiz, Itziar Valverde-Pascual, Jacobo Cal-Gonzalez, Thomas Beyer, Ignasi Carrio
Aim: The aim of this study is to evaluate the physical performance of the Philips Vereos whole-body PET/CT system according to the NEMA NU2-2012 standard and to compare it to other state-of-the-art PET/CT systems. Methods: Spatial resolution, sensitivity, count-rate performance, count rate accuracy and image quality were assessed. Specifically, spatial resolution was measured using an 18 F point-source. System sensitivity was calculated from acquisitions of an 18 F line-source inside Al-tubes with varying thickness...
October 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30361381/test-retest-reproducibility-of-fdg-pet-ct-uptake-in-cancer-patients-within-a-qualified-and-calibrated-local-network
#20
Brenda F Kurland, Lanell M Peterson, Andrew T Shields, Jean H Lee, Darrin W Byrd, Alena Novakova-Jiresova, Mark Muzi, Jennifer M Specht, David A Mankoff, Hannah M Linden, Paul E Kinahan
Calibration and reproducibility of quantitative 18 F-fluorodeoxyglucose (FDG) PET measures are essential for adopting integral FDG-PET/CT biomarkers and response measures in multicenter clinical trials. We implemented a multicenter qualification process using NIST-traceable reference sources for scanners and dose calibrators, and similar patient and imaging protocols. We then assessed standardized uptake value (SUV) in patient test-retest studies. Methods: Five FDG-PET/CT scanners from 4 institutions (2 in a NCI-designated Comprehensive Cancer Center, 3 in a community-based network) were qualified for study use...
October 25, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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