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Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

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https://www.readbyqxmd.com/read/28082440/a-validation-study-of-automated-bone-scan-index-effect-on-reproducibility-due-to-the-procedural-variability-in-bone-scan-image-acquisition-a-common-mistake
#1
Siamak Sabour
No abstract text is available yet for this article.
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082439/dissociation-between-brown-adipose-tissue-18f-fdg-uptake-and-thermogenesis-in-uncoupling-protein-1-deficient-mice
#2
Mohammed K Hankir, Mathias Kranz, Susanne Keipert, Juliane Weiner, Sille G Andreasen, Matthias Kern, Marianne Patt, Nora Klöting, John T Heiker, Swen Hesse, Peter Brust, Martin Jastroch, Wiebke Fenske
: (18)F-FDG PET imaging is routinely used to investigate brown adipose tissue (BAT) thermogenesis which requires mitochondrial uncoupling protein 1 (UCP1). It remains uncertain whether BAT (18)F-FDG uptake reliably tracks UCP1-mediated heat production. METHODS: UCP1 knockout (UCP1 KO) and wild-type mice received the selective β3 adrenergic receptor agonist CL 316, 243 (1mg/kg) and underwent metabolic cage, infrared thermal imaging and (18)F-FDG PET/magnetic resonance imaging (MRI) experiments...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082438/the-impact-of-sstr-directed-pet-ct-on-the-management-of-patients-with-neuroendocrine-tumor-a-systematic-review-and-meta-analysis
#3
Martin Barrio, Johannes Czernin, Stefano Fanti, Valentina Ambrosini, Ina Binse, Lin Du, Matthias Eiber, Ken Herrmann, Wolfgang Peter Fendler
INTRODUCTION: Somatostatin receptor (SSTR) imaging is widely used for guiding the management of neuroendocrine tumor (NET) patients. (68)Ga-DOTATATE approval by the US Food and Drug Administration has triggered widespread clinical interest in SSTR Positron Emission Tomography/Computed Tomography (PET/CT) throughout the US. Here we performed a systematic review and meta-analysis to evaluate the impact of SSTR PET/CT on the management of patients with NETs. METHODS: A comprehensive literature search was performed using The National Center for Biotechnology Information PubMed online database applying the following keywords: "management" AND "PET" AND "neuroendocrine"...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082437/whole-body-18f-fdg-pet-ct-is-superior-to-ct-as-first-line-diagnostic-imaging-in-patients-referred-with-serious-non-specific-symptoms-or-signs-of-cancer-a-randomized-prospective-study-of-200-patients
#4
Anne-Mette Lebech, Anne Gaardsting, Annika Loft, Jesper Graff, Elena Markova, Anne Kiil Berthelsen, Jan Lysgaard Madsen, Morten Helms, Lars R Mathiesen, Kim P David, Gitte Kronborg, Andreas Kjaer
: A fast-track pathway has been established in Denmark to investigate patients with serious non-specific symptoms and signs of cancer (NSSC), which are not eligible to enter an organ-specific cancer program. The prevalence of cancer in this cohort is approximately 20%. The optimal screening strategy in patients with NSSC remains unknown. The aim was to investigate if (18)F-FDG-positron emission tomography/computed tomography (PET/CT) was superior to CT as initial imaging modality in patients with NSSC...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082436/resin-versus-glass-microspheres-for-yttrium-90-transarterial-radioembolization-comparing-survival-in-unresectable-hepatocellular-carcinoma-using-pretreatment-partition-model-dosimetry
#5
Axel VAN DER Gucht, Mario Jreige, Alban Denys, Paul Blanc-Durand, Ariane Boubaker, Anastasia Pomoni, Periklis Mitsakis, Marina Silva-Monteiro, Silvano Gnesin, Marie Nicod-Lalonde, Rafael Duran, John Prior, Niklaus Schaefer
: The aim of this study was to compare survival of patients treated for unresectable hepatocellular carcinoma (uHCC) with Yttrium-90 ((90)Y) transarterial radioembolization (TARE) using pretreatment partition model dosimetry (PMD). METHODS: We performed a retrospective analysis of prospectively collected data on 77 consecutively treated (mean age 66.4 12.2 y) for uHCC (36 uni-nodular, 5 multi-nodular, 36 diffuse) with (90)Y TARE (41 resin, 36 glass) using pretreatment PMD...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082435/cumulated-activity-comparison-of-64cu-177lu-labeled-anti-egfr-antibody-in-esophageal-squamous-cell-carcinoma-model
#6
Eric Laffon, Matthieu Thumerel, Jacques Jougon, Roger Marthan
OBJECTIVE: This work aimed at estimating kinetic parameters, and hence cumulated activity (AC), of a diagnostic/therapeutic convergence radiopharmaceutical, namely (64)Cu-/(177)Lu-labeled antibody ((64)Cu-/(177)Lu-cetuximab), that acts as anti-epidermal growth factor receptor (EGFR). METHODS: In mice bearing esophageal squamous cell carcinoma (ESCC) tumor, to estimate uptake (K), release rate constant (kR), and hence cumulated activity, a kinetic model analysis was applied to recently published biodistribution data of immuno-PET imaging with (64)Cu-cetuximab and of micro-SPECT/CT imaging with (177)Lu-cetuximab, including blood and TE-8 tumor...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082434/89zr-bevacizumab-pet-potential-early-read-out-for-efficacy-of-everolimus-in-metastatic-renal-cell-carcinoma-patients
#7
Suzanne C van Es, Adrienne H Brouwers, Shekar V K Mahesh, Annemarie M Leliveld-Kors, Igle J de Jong, Marjolijn N Lub-de Hooge, Elisabeth G E de Vries, Jourik A Gietema, Sjoukje F Oosting
RATIONALE: Currently, biomarkers that predict efficacy of everolimus in metastatic renal cell carcinoma (mRCC) patients are lacking. Everolimus inhibits vascular endothelial growth factor A (VEGF-A) expression. We performed PET scans in mRCC patients with (89)Zr-bevacizumab, a VEGF-A-binding antibody tracer. Aims were to determine change in tumor tracer uptake after start of everolimus and to explore if (89)Zr-bevacizumab PET can identify patients with early disease progression. METHODS: (89)Zr-bevacizumab PET was done before and 2 and 6 weeks after start of everolimus 10 mg/day in mRCC patients...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082433/optimization-of-labeling-psmahbed-with-68ga-and-its-quality-control-systems
#8
Elisabeth Eppard, Tatjana Homann, Ana de la Fuente, Markus Essler, Frank Roesch
Radiolabeling of the prostate-specific membrane antigen (PSMA) inhibitor, Glu-NH-CO-NH-Lys (Ahx), using the (68)Ga chelator HBED-CC (PSMAHBED) allows imaging of lesions of prostate cancer due to the high expression of PSMA in prostate carcinoma cells as well as bone metastases and lymph nodes related to the disease. The aim of this work was the optimization of the labeling of (68)Ga-PSMAHBED using the efficient cation exchange (CEX) post-processing of (68)Ga as well as the development of a TLC-based quality control system...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28082432/quantification-of-lung-pet-images-challenges-and-opportunities
#9
Delphine L Chen, Joseph Cheriyan, Edwin Chilvers, Gourab Choudoury, Christopher Coello, Martin Connell, Marie Fisk, Ashley M Groves, Roger N Gunn, Beverley F Holman, Brian F Hutton, Sarah Lee, William MacNee, Divya Mohan, David Parr, Deepak Subramanian, Ruth Tal-Singer, Kris Thielemans, Edwin Jr van Beek, Laurence Vass, Jeremy W Wellen, Ian Wilkinson, Frederick J Wilson
Millions of people are affected by respiratory diseases, leading to a significant health burden globally. Due to the current insufficient knowledge of the underlying mechanisms that lead to the development and progression of respiratory diseases, treatment options remain limited. To overcome this limitation and understand the associated molecular changes, non-invasive imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography have been explored for biomarker development, with (18)F-fluorodeoxyglucose ((18)F-FDG) PET imaging being the most studied...
January 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28062599/in-vivo-evaluation-of-11c-preladenant-for-pet-imaging-of-adenosine-a2a-receptors-in-the-conscious-monkey
#10
Xiaoyun Zhou, Ronald Boellaard, Kiichi Ishiwata, Muneyuki Sakata, Rudi A Dierckx, Johan de Jong, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Erik F de Vries, Philip H Elsinga
: [(11)C]Preladenant was developed as a novel PET ligand for the adenosine A2A receptors (A2ARs). The present study aims to evaluate the suitability of [(11)C]preladenant-PET for the quantification of striatal A2ARs and the assessment of A2AR occupancy in the conscious monkey brain. METHODS: [(11)C]Preladenant was i.v. injected into conscious monkeys (n = 4, 18 PET scans) and a 91-min dynamic scan was started. Arterial blood samples in combination with metabolite analysis were obtained during the scan to provide the input function for kinetic modelling...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28062598/fact-sheet-about-interim-and-end-of-treatment-18f-fdg-pet-ct-in-lymphoma
#11
Hugo J A Adams, Thomas Christian Kwee
No abstract text is available yet for this article.
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28062597/the-effect-of-susceptibility-artifacts-related-to-metal-implants-on-adjacent-lesion-assessment-in-simultaneous-tof-pet-mr
#12
Hanna Svirydenka, Gaspar Delso, Felipe DE Galiza Barbosa, Martin W Huellner, Helen Davison, Stefano Fanti, Patrick Veit-Haibach, Edwin Ter Voert
OBJECTIVE: Metal implants could affect the attenuation correction (AC) in positron emission tomography (PET)/magnetic resonance (MR) imaging. The purpose of this study is to evaluate the effect of susceptibility artifacts related to metal implants on adjacent metabolically active lesions in clinical simultaneous PET/MR scanning for both time-of-flight (TOF) and non-TOF reconstructed PET images. METHODS: We included 27 patients without implants, but with confirmed 2-deoxy-2-(18)F-fluoro-D-glucose ((18)F-FDG) avid lesions adjacent to common implant locations...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#13
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28062595/the-clinical-impact-of-additional-late-pet-ct-imaging-with-68ga-psma-11-hbed-cc-in-the-diagnosis-of-prostate-cancer
#14
Ali Afshar-Oromieh, Lars Peter Sattler, Walter Mier, Boris Hadaschik, Jürgen Debus, Tim Holland-Letz, Klaus Kopka, Uwe Haberkorn
PURPOSE: While Positron Emission Tomography/Computed Tomography (PET/CT) with (68)Ga-PSMA-11 in the diagnosis of prostate cancer (PCa) is routinely performed at 1h post injection (p.i.), later scans may be beneficial since most lesions present with higher uptake and contrast. This evaluation aimed to investigate the clinical impact of additional late (68)Ga-PSMA-11-PET/CT. METHODS: Between 2011 and 2016, 112 patients with PCa who received early (at 1h p.i.) and late (at 3h p...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27980051/4-11c-methoxy-n-2-diethylaminoethyl-benzamide-a-novel-probe-to-selectively-target-melanoma
#15
Pradeep K Garg, Rachid Nazih, Yanjun Wu, Ravi A Singh, Sudha Garg
: We report the synthesis and preclinical evaluation of (11)C-labeled novel probe to target melanoma using Positron Emission Tomography (PET). METHODS: The target compound 4-(11)-Cmethoxy N-(2-diethylaminoethyl) benzamide (4-(11)C-MBZA) was prepared via the (11)C-methylation of 4-hydroxy N-(2-diethylaminoethyl) benzamide (4-HBZA). The in vitro binding was performed using B16F1 (Melanoma cells), MCF-10A (breast epithelial cells) and MDA-MB 231 (breast cancer cells)...
December 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27980050/in-vivo-pet-imaging-of-the-cancer-integrin-%C3%AE-v%C3%AE-6-using-gallium-68-labelled-cyclic-rgd-nonapeptides
#16
Johannes Notni, Dominik Reich, Oleg V Maltsev, Tobias G Kapp, Katja Steiger, Frauke Hoffmann, Irene Esposito, Wilko Weichert, Horst Kessler, Hans-Jürgen Wester
: Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to malignant epithelial cells in carcinomas of a broad variety of lineages, while it is virtually absent in normal adult tissues. Thus, it is a highly attractive target for tumor imaging and therapy. Furthermore, αvβ6 integrin plays an important role for the epithelial-mesenchymal interaction and the development of fibrosis. METHODS: On the basis of the Gallium-68 chelators TRAP (triazacyclononane-triphosphinate) and NODAGA, we synthesized mono- di- and trimeric conjugates of the αvβ6 integrinselective peptide cyclo(FRGDLAFp(NMe)K) via click chemistry (CuAAC)...
December 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27980049/whole-body-fdg-pet-and-fdg-pet-ct-in-patients-with-suspected-paraneoplastic-syndrome-a-systematic-review-and-meta-analysis-of-diagnostic-accuracy
#17
Sara Sheikhbahaei, Charles Marcus, Roberto S Fragomeni, Steven P Rowe, Mehrbod S Javadi, Lilja B Solnes
: The purpose of this study was to assess the diagnostic performance of whole body (18)F-FDG-PET or (18)F-FDG-PET/CT for detection of underlying malignancy in patients with clinically suspected neurological and non-neurological paraneoplastic syndromes. METHODS: A systematic search was performed in PubMed (Medline), Embase, Scopus (last updated November 2016) to identify relevant published studies reporting the performance of (18)F-FDG-PET or (18)F-FDG-PET/CT in patients with suspected paraneoplastic syndrome...
December 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27980048/influence-of-animal-heating-on-pet-imaging-quantification-and-kinetics-results-on-the-biodistribution-of-18f-tetrafluoroborate-and-18f-fdg-in-mice
#18
Christian Goetz, Matthias Podein, Friederike Braun, Wolfgang A Weber, Philippe Choquet, André Constantinesco, Michael Mix
: Varying environmental conditions under anesthesia may lead to unstable homeostatic conditions in rodents and thus alter kinetics. This study evaluated the impact of varying heating conditions on PET imaging quantification. METHODS: Two groups of six adult female balb-c nude mice with subcutaneously implanted tumors underwent microPET imaging after injection of (18)F-tetrafluoroborate and (18)F-fluordeoxyglucose respectively. Dynamic scans were acquired under optimal and sub-optimal heating conditions...
December 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27980047/practical-immunopet-radiotracer-design-considerations-for-human-immune-checkpoint-imaging
#19
Aaron Thomas Mayer, Arutselvan Natarajan, Sydney Gordon, Roy Maute, Melissa McCracken, Aaron Ring, Irving Weissman, Sam Sanjiv Gambhir
Immune checkpoint blockade has emerged as a promising cancer treatment paradigm. Unfortunately, there are still a large number of patients and malignancies that do not respond to therapy. A major barrier to validating biomarkers for the prediction and monitoring of responders to clinical checkpoint blockade has been the lack of imaging tools to accurately assess dynamic immune checkpoint expression. Here we sought to optimize noninvasive ImmunoPET (positron emission tomography) imaging of human PD-L1 expression, in a pre-clinical model, using a small high affinity engineered protein scaffold (HAC-PD1)...
December 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27980046/pet-quantification-of-the-norepinephrine-transporter-in-human-brain-with-s-s-18f-fmener-d2
#20
Sho Moriguchi, Yasuyuki Kimura, Masanori Ichise, Ryosuke Arakawa, Harumasa Takano, Chie Seki, Yoko Ikoma, Keisuke Takahata, Tomohisa Nagashima, Makiko Yamada, Masaru Mimura, Tetsuya Suhara
: Norepinephrine transporter (NET) in the brain plays important roles in human cognition and the pathophysiology of psychiatric disorders. Two radioligands, (S,S)-(11)C-MRB and (S,S)-(18)F-FMeNER-D2, have been used for imaging NETs in the thalamus and midbrain (including locus coeruleus) using positron emission topography (PET) in humans. However, NET density in the equally important cerebral cortex has not been well quantified because of unfavorable kinetics with (S,S)-(11)C-MRB and defluorination with (S,S)-(18)F-FMeNER-D2, which can complicate NET quantification in the cerebral cortex adjacent to the skull containing defluorinated (18)F radioactivity...
December 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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