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Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

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https://www.readbyqxmd.com/read/30002112/-68-ga-psma-is-a-novel-pet-ct-tracer-for-imaging-of-hepatocellular-carcinoma-a-prospective-pilot-study
#1
Mikhail Kesler, Charles Levine, Dov Hershkovitz, Eyal Mishani, Yoram Menachem, Hedva Lerman, Yaniv Zohar, Oren Shibolet, Einat Even-Sapir
Background: 68 Ga-Prostate Specific Membrane Antigen (68 Ga-PSMA), a positron emission tomography (PET) tracer that was recently introduce for imaging of prostate cancer, may accumulate in other solid tumors including Hepatocellular Carcinoma (HCC). The aim of the study was to assess the potential role of 68 Ga-PSMA PET-Computed Tomography (CT) for imaging of HCC. Material and Methods: A prospective pilot study in seven patients with HCC with 41 liver lesions: 37 suspected malignant lesions (tumor lesions) and 4 regenerative nodules...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30002111/assessment-of-physiological-intracranial-calcification-in-healthy-adults-using-18-f-naf-pet-ct
#2
Abdullah Al-Zaghal, Siavash Mehdizadeh Seraj, Thomas J Werner, Oke Gerke, Poul F Høilund-Carlsen, Abass Alavi
The aim of this research study was to determine the role of 18 F-Sodium fluoride (NaF) PET/CT imaging in the assessment of physiologic molecular calcification in the intra-cranial structures. We also examined the association of NaF accumulation with age as well as Hounsfield unit (HU) in certain anatomical sites that are known to calcify with normal aging. Methods: A total of 78 healthy subjects from the Cardiovascular Molecular Calcification Assessed by 18 F-NaF PET/CT (CAMONA) clinical trial (38 females and 40 males) were included in this retrospective study...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30002110/-standing-by-for-bystander-effects-dual-isotope-imaging-of-antibody-drug-conjugate-and-payload-distribution
#3
Cornelius Cilliers, Greg M Thurber
No abstract text is available yet for this article.
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30002109/the-relevance-of-dosimetry-in-precision-medicine
#4
Michael Lassmann, Uta Eberlein
The aim of this review is to provide an overview of the most recent technological developments in state-of-the-art equipment and tools used for dosimetry in radionuclide therapies. This includes, but is not restricted to calibration methods of imaging systems. In addition, a summary of new developments that consider the influence of small-scale dosimetry and of biological effects on radionuclide therapies is given. Finally, the present-day limitations of patient-specific dosimetry such as bone-marrow dosimetry or dosimetry of alpha emitters are discussed...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30002108/outcome-after-psma-pet-ct-based-salvage-radiotherapy-in-patients-with-biochemical-recurrence-after-radical-prostatectomy-a-bi-institutional-retrospective-analysis
#5
Nina-Sophie Schmidt-Hegemann, Christian Stief, Tak-Hyun Kim, Chukwuka Eze, Simon Kirste, Iosif Strouthos, Minglun Li, Wolfgang Schultze-Seemann, Harun Ilhan, Wolfgang Peter Fendler, Peter Bartenstein, Anca-Ligia Grosu, Ute Ganswindt, Claus Belka, Philipp T Meyer, Constantinos Zamboglou
Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) detects prostate cancer recurrence at low PSA levels. Radiotherapy with dose escalation to the former prostate bed has been associated with improved biochemical recurrence-free survival (BRFS). Thus, we hypothesized that PSMA PET/CT-guided salvage radiotherapy leads to improved BRFS. Methods: A total of 204 consecutive patients were referred for salvage radiotherapy following radical prostatectomy. PSMA PET/CT scans were performed and patients with PSA persistence (109 patients) or evidence of distant metastases (5 patients) were excluded from this analysis...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30002107/targeting-of-the-cholecystokinin-2-receptor-with-the-minigastrin-analog-177-lu-dota-pp-f11n-does-the-use-of-protease-inhibitors-further-improve-in-vivo-distribution
#6
Alexander Walter Sauter, Rosalba Mansi, Ulrich Hassiepen, Lionel Muller, Tania Panigada, Stefan Wiehr, Anna-Maria Wild, Susanne Geistlich, Martin Béhé, Christof Rottenburger, Damian Wild, Melpomeni Fani
Patients with metastatic medullary thyroid cancer (MTC) have limited systemic treatment options. The use of radiolabeled gastrin analogs targeting the cholecystokinin-2 receptor (CCK2R) is an attractive approach. However, their therapeutic efficacy is presumably decreased by their enzymatic degradation in vivo. We aimed to investigate whether the chemically stabilized analog 177 Lu-DOTA-PP-F11N (177 Lu-DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2) performs better than reference analogs with varying in vivo stability, namely 177 Lu-DOTA-MG11 (177 Lu-DOTA-DGlu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) and 177 Lu-DOTA-PP-F11 (177 Lu-DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2), and if the use of protease inhibitors further improves CCKR2-targeting...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29980581/-18-f-hx4-hypoxia-pet-holds-promise-as-a-prognostic-and-predictive-imaging-biomarker-in-a-lung-cancer-xenograft-model-treated-with-metformin-and-radiotherapy
#7
Sven De Bruycker, Christel Vangestel, Tim Van den Wyngaert, Patrick Pauwels, Leonie Wyffels, Steven Staelens, Sigrid Stroobants
Metformin may improve tumor oxygenation and thus radiotherapy response, but imaging biomarkers for selection of suitable patients are still under investigation. First, we assessed the effect of acute metformin administration on non-small cell lung cancer (NSCLC) xenograft tumor hypoxia using positron emission tomography (PET) imaging with the hypoxia tracer 18 F-flortanidazole (18 F-HX4). Second, we verified the effect of a single dose of metformin prior to radiotherapy on long-term treatment outcome. Third, we examined the potential of baseline 18 F-HX4 as a prognostic and/or predictive biomarker for treatment response...
July 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29976698/characterization-of-noise-and-resolution-for-quantitative-177-lu-spect-ct-with-xspect-quant
#8
Johannes Tran-Gia, Michael Lassmann
Quantitative SPECT/CT imaging forms the basis for internal dosimetry in molecular radiotherapies. While the conversion from counts to activity is typically performed based on conversion factors individually measured by each site, a recently introduced commercially available reconstruction (xSPECT Quant) offers a standardized and traceable calibration of SPECT/CT systems. The aim of this work was to assess the characteristics of xSPECT Quant in combination with 177 Lu as one of the most important radionuclides used in molecular radiotherapies and to compare it to a widely used ordered subset expectation maximization reconstruction (Flash3D)...
July 5, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29976697/-68-ga-psma-11-pet-ct-in-primary-and-recurrent-prostate-carcinoma-implications-for-radiotherapeutic-management-in-121-patients
#9
Stefan A Koerber, Leon Will, Clemens Kratochwil, Matthias F Haefner, Henrik Rathke, Christophe Kremer, Jonas Merkle, Klaus Herfarth, Klaus Kopka, Peter L Choyke, Tim Holland-Letz, Uwe Haberkorn, Juergen Debus, Frederik L Giesel
The present study analyzed the impact of Gallium-68 (68 Ga)-labeled prostate-specific membrane antigen-HBED-CC (68 Ga-PSMA-11) positron-emission tomography (PET)/computed tomography (CT) on radiotherapeutic management in a large cohort of men with primary or recurrent disease. Methods: This study investigated 121 men with carcinoma of the prostate who underwent 68 Ga-PSMA-11 PET/CT as well as conventional imaging. 50 patients were treatment naive, 11 had persistent prostate-specific antigen (PSA) soon after surgery and 60 presented with recurrent PSA following definitive therapy...
July 5, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29976696/insights-into-trace-metal-metabolism-in-health-and-disease-from-pet-pet-metallomics
#10
Joanna Julia Bartnicka, Philip Blower
Essential trace metals such as copper, zinc, iron and manganese play multiple critical functions in cellular and physiological processes including catalytic, regulatory and signalling roles. Metal homeostasis is crucial for human health, and its role in the pathogenesis of diseases such as dementia, cancer and inherited metabolic abnormalities is emerging. Intracellular pathways implicated in the function of essential metals have been extensively studied but the whole-body fluxes and the mechanisms of transport between different compartments remain poorly understood...
July 5, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29976695/-11-c-dpa-713-versus-18-f-ge-180-a-preclinical-comparison-of-tspo-pet-tracers-to-visualize-acute-and-chronic-neuroinflammation-in-a-mouse-model-of-ischemic-stroke
#11
Aisling Chaney, Haley C Cropper, Emily M Johnson, Kendra J Lechtenberg, Todd C Peterson, Marc Y Stevens, Marion S Buckwalter, Michelle L James
Neuroinflammation plays a key role in neuronal injury following ischemic stroke. Positron emission tomography (PET) imaging of translocator protein 18 kDa (TSPO) permits longitudinal, non-invasive visualization of neuroinflammation in both pre-clinical and clinical settings. Many TSPO tracers have been developed, however it is unclear which tracer is the most sensitive and accurate for monitoring the in vivo spatiotemporal dynamics of neuroinflammation across applications. Hence, there is a need for head-to-head comparisons of promising TSPO-PET tracers across different disease states...
July 5, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959218/vt-substrate-characteristics-insights-from-multi-modality-structural-and-functional-imaging-of-the-vt-substrate-using-cmr-scar-123-i-mibg-spect-innervation-and-bipolar-voltage
#12
Hasan Imanli, Kiddy L Ume, Jean Jeudy, Tamunoinemi Bob-Manuel, Mark F Smith, Wengen Chen, Mohammed Abdulghani, Yousra Ghzally, Jagat Bandhu Mahat, Refael Itah, Alejandro Restrepo, Vincent Y See, Stephen Shorofsky, Vasken Dilsizian, Timm Dickfeld
Background - Post-Ischemic adaptation results in characteristic myocardial structural and functional changes of the VT(Ventricular Tachycardia) substrate. Objective - Compare myocardial structural/functional adaptation (late gadolinium-enhancement(LGE)/abnormal innervation) with detailed VT mapping data to identify regional heterogeneities of post-ischemic changes. Methods - Fifteen patients with ischemic cardiomyopathy and drug-refractory VT underwent LGE-Cardiac magnetic resonance imaging(CMR), 123 I-mIBG-SPECT and high-resolution bipolar voltage mapping to assess fibrosis(>3SD), abnormal innervation(<50% tracer uptake) and low-voltage areas(<1...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959217/the-additional-value-of-pet-in-the-assessment-of-cerebral-small-vessel-disease
#13
Wolf-Dieter Heiss
The diagnosis of cerebral small vessel disease (SVD) is difficult because there is no consensus on clinical criteria and therefore, imaging is important for diagnosis. Most patients undergo brain imaging by computed tomography (CT), which is able to detect ischemic strokes, hemorrhages and brain atrophy and may also indicate white matter changes. Magnetic resonance imaging (MRI) remains the key neuroimaging modality and is preferred to CT in vascular cognitive impairment (VCI) because it has higher sensitivity and specificity for detecting pathological changes...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959216/targeting-micrometastases-the-effect-of-heterogeneous-radionuclide-distribution-on-tumor-control-probability
#14
Nadia Falzone, Boon Quan Lee, Sarah Able, Javian Malcolm, Samantha Terry, Yasir Alayed, Katherine Anne Vallis
The spatial distribution of radiopharmaceuticals that emit short-range high linear-energy-transfer electrons greatly affects the absorbed dose and their biological effectiveness. The purpose of this study was to investigate the effect of heterogeneous radionuclide distribution on tumor control probability (TCP) in a micrometastases model. Methods: Cancer cell lines; MDA-MB-468, SQ20B and 231-H2N were grown as spheroids to represent micrometastases. The intracellular distribution of a representative radiopeptide (111 In-labelled epidermal growth factor, EGF) and radioimmunotherapeutic (111 In-labelled Trastuzumab) was determined in cell internalization experiments...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959215/evaluation-of-two-potent-and-selective-pet-radioligands-to-image-cox-1-and-cox-2-in-rhesus-monkeys
#15
Min-Jeong Kim, Stal S Shrestha, Michelle Cortes, Prachi Singh, Cheryl Morse, Jeih-San Liow, Robert L Gladding, Chad Brouwer, Katharine Henry, Evan Gallagher, George L Tye, Sami S Zoghbi, Masahiro Fujita, Victor W Pike, Robert B Innis
This study assessed whether the newly developed PET radioligands 11 C-PS13 and 11 C-MC1 could image constitutive levels of cyclooxygenase-1 (COX-1) and COX-2, respectively, in rhesus monkeys. Methods: After intravenous injection of either radioligand, 24 whole-body PET scans were performed. To measure enzyme-specific uptake, scans of the two radioligands were also performed after administration of a non-radioactive drug preferential for either COX-1 or COX-2. Concurrent venous samples were obtained to measure parent radioligand concentrations...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959214/glycoprotein-iib-iiia-receptor-imaging-with-18-f-gp1-positron-emission-tomography-for-acute-venous-thromboembolism-an-open-label-non-randomized-first-in-human-phase-1-study
#16
Chanwoo Kim, Jae Seung Lee, Youngjin Han, Sun Young Chae, Soyoung Jin, Changhwan Sung, Hye Joo Son, Seung Jun Oh, Sang Ju Lee, Jungsu S Oh, Yong-Pil Cho, Tae-Won Kwon, Deok Hee Lee, Seongsoo Jang, Bohyun Kim, Norman Koglin, Mathias Berndt, Andrew W Stephens, Dae Hyuk Moon
18 F-GP1 is a derivative of elarofiban with a high affinity to activated platelet glycoprotein IIb/IIIa (GPIIb/IIIa) and favorable in vivo characteristics for thrombus imaging in preclinical models. We aimed to explore the detection rate of thromboembolic foci with 18 F-GP1 positron emission tomography/computed tomography (PET/CT) in patients with acute venous thromboembolism (VTE), and to evaluate the safety, biodistribution, pharmacokinetics, and metabolism of 18 F-GP1. Methods: We studied patients who had signs or symptoms of acute deep vein thrombosis (DVT) of the leg or acute pulmonary embolism (PE) within 14 days prior to 18 F-GP1 PET/CT, and had thromboembolic foci confirmed by conventional imaging ( n = 10 for DVT and n = 10 for PE)...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959213/combination-treatment-of-vla-4-targeted-radionuclide-therapy-and-immunotherapy-in-a-mouse-model-of-melanoma
#17
Jaeyeon Choi, Wissam Beaino, Ronald Fecek, Kellsye Fabian, Charles M Laymon, Brenda Kurland, Walter Storkus, Carolyn J Anderson
Very late antigen-4 (VLA-4; also known as integrin α4β1) is expressed at high levels in aggressive and metastatic melanoma tumors and may provide an ideal target for imaging and targeted radiotherapy. 177 Lu-DOTA-PEG4-LLP2A (177 Lu-LLP2A) shows high affinity for VLA-4 and had high uptake in B16F10 mouse melanoma tumors in vivo. Here, we report efficacy studies of 177 Lu-LLP2A, alone and combined with immune checkpoint inhibitors (ICI) in B16F10 tumor-bearing mice. Methods: B16F10 tumor cells (1 x 106) were implanted subcutaneously in C57BL/6 mice...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959212/metabolic-active-tumor-volume-and-total-lesion-glycolysis-by-18-f-fdg-pet-ct-validated-as-prognostic-imaging-biomarkers-in-chemorefractory-metastatic-colorectal-cancer
#18
Erwin Woff, Alain Hendlisz, Lieveke Ameye, Camilo Garcia, Tarek Kamoun, Thomas Guiot, Marianne Paesmans, Patrick Flamen
This study aimed to validate the prognostic value of baseline whole-body metabolic active tumor volume (WB-MATV) and total lesion glycolysis (WB-TLG) measured with [18 F]fluorodeoxyglucose positron emission tomography-computed tomography (18 F-FDG PET/CT) in a large cohort of chemorefractory metastatic colorectal cancer (mCRC) patients treated with multikinase inhibitors (MKI). The secondary objective of this study was to compare WB-MATV and WB-TLG respective prognostic values to commonly used clinical prognostic factors...
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29959211/radiopharmaceutical-therapy-in-the-new-millenium
#19
Chaitanya R Divgi
No abstract text is available yet for this article.
June 29, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29934408/controversies-in-the-use-of-radioiodine-in-thyroid-cancer-we-need-more-and-better-data
#20
Daniel A Pryma
No abstract text is available yet for this article.
June 22, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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