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Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

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https://www.readbyqxmd.com/read/28408533/brachytherapy-with-intratumoral-injections-of-radiometal-labeled-polymers-that-thermo-responsively-self-aggregate-in-tumor-tissues
#1
Kohei Sano, Yuko Kanada, Kengo Kanazaki, Ning Ding, Masahiro Ono, Hideo Saji
Brachytherapy is a type of radiotherapy wherein titanium capsules containing therapeutic radioisotopes are implanted within tumor tissues, enabling high-dose radio-irradiation to tumor tissues around the seeds. Although marked therapeutic effects have been demonstrated, brachytherapy needs complicated implantation technique under general anesthesia and the seeds could migrate to other organs. The aim of this study is to establish a novel brachytherapy using biocompatible, injectable thermo-responsive polymers (polyoxazoline; POZ) labeled with yttrium-90 ((90)Y), which can self-aggregate above a specific transition temperature, resulting in long-term intratumoral retention of radioactivity and therapeutic effect...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408532/-68-ga-thp-psma-a-pet-imaging-agent-for-prostate-cancer-offering-rapid-room-temperature-one-step-kit-based-radiolabeling
#2
Jennifer D Young, Vincenzo Abbate, Cinzia Imberti, Levente K Meszaros, Michelle T Ma, Samantha Y A Terry, Robert C Hider, Greg E Mullen, Philip J Blower
The clinical impact and accessibility of (68)Ga tracers for the prostate-specific membrane antigen (PSMA) and other targets would be greatly enhanced by the availability of a simple, one-step kit-based labeling process. Radiopharmacy staff are accustomed to such procedures in the daily preparation of (99m)Tc radiopharmaceuticals. Currently, chelating agents used in (68)Ga radiopharmaceuticals do not meet this ideal. AIM: To develop and evaluate preclinically a (68)Ga radiotracer for imaging PSMA expression that could be radiolabeled simply by addition of (68)Ga generator eluate to a cold kit...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408531/-68-ga-psma-11-pet-ct-interobserver-agreement-for-prostate-cancer-assessments-an-international-multicenter-prospective-study
#3
Wolfgang Peter Fendler, Jeremie Calais, Martin Allen-Auerbach, Christina Bluemel, Nina Eberhardt, Louise Emmett, Pawan Gupta, Markus Hartenbach, Thomas A Hope, Shozo Okamoto, Christian Helmut Pfob, Thorsten D Pöppel, Christoph Rischpler, Sarah Schwarzenböck, Vanessa Stebner, Marcus Unterrainer, Helle D Zacho, Tobias Maurer, Christian Gratzke, Alexander Crispin, Johannes Czernin, Ken Herrmann, Matthias Eiber
Background: The interobserver agreement for (68)Ga-PSMA-11 Positron Emission Tomography/Computed Tomography (PET/CT) study interpretations in patients with prostate cancer is unknown. Methods:(68)Ga-PSMA-11 PET/CT was performed in 50 patients with prostate cancer for biochemical recurrence (n = 25), primary diagnosis (n = 10), biochemical persistence after primary therapy (n = 5) or staging of known metastatic disease (n = 10). Images were reviewed by 16 observers who used a standardized approach for interpretation of local (T), nodal (N), bone (Mb), or visceral (Mc) involvement...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408530/alternative-means-of-estimating-131-i-maximum-permissible-activity-to-treat-thyroid-cancer
#4
Kenneth J Nichols, William Robeson, Miyuki Yoshida-Hay, Pat B Zanzonico, Fritzgerald C Leveque, Kuldeep K Bhargava, Gene G Tronco, Christopher J Palestro
To protect bone marrow from over-irradiation, maximum permissible activity (MPA) of iodine-131 ((131)I) to treat thyroid cancer is that which limits absorbed dose to blood (as a surrogate of marrow) to < 200 cGy. The conventional approach (Method-1) requires repeated gamma-camera whole-body measurements along with blood samples. We sought to determine whether reliable MPA values can be obtained by simplified procedures. Methods: Data acquired over multiple time points were examined retrospectively for 65 thyroid cancer patients, referred to determine (131)I uptake and MPA for initial treatment following thyroidectomy (N = 39), including 17 patients with compromised renal function and 22 patients with known (N = 16) or suspected (N = 6) metastases...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408529/targeted-alpha-therapy-of-mcrpc-with-225-actinium-psma-617-dosimetry-estimate-and-empirical-dose-finding
#5
Clemens Kratochwil, Frank Bruchertseifer, Hendrik Rathke, Marcus Bronzel, Christos Apostolidis, Wilko Weichert, Uwe Haberkorn, Frederick Lars Giesel, Alfred Morgenstern
To develop a treatment protocol for (225)Ac-PSMA-617 alpha-radiation therapy in advanced stage, metastatic castration-resistant prostate cancer patients with PSMA-positive tumor phenotype. Methods: A dosimetry estimate was calculated based on time-activity-curves derived from serially performed (177)Lu-PSMA-617 scans extrapolated to the physical half-life of (225)Ac, assuming instant decay of instable daughter nuclides. Salvage therapies empirically conducted with 50kBq/kg (n = 4), 100kBq/kg (n = 4), 150kBq/kg (n = 2), 200kBq/kg (n = 4) (225)Ac-PSMA-617 were evaluated retrospectively regarding toxicity and treatment response...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408528/cerenkov-radiation-induced-photoimmunotherapy-with-18-f-fdg
#6
Yuko Nakamura, Tadanobu Nagaya, Kazuhide Sato, Shuhei Okuyama, Fusa Ogata, Karen J Wong, Stephen Adler, Peter L Choyke, Hisataka Kobayashi
Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photo-absorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is ultraviolet and blue light which is produced by a charged particle travelling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408527/the-future-of-radioligand-therapy-alpha-beta-or-both
#7
Uwe A Haberkorn, Frederik Giesel, Alfred Morgenstern, Clemens Kratochwil
No abstract text is available yet for this article.
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408526/gallium-68-or-fluorine-18-for-prostate-cancer-imaging
#8
Claudia Kesch, Clemens Kratochwil, Walter Mier, Klaus Kopka, Frederik L Giesel
The introduction of prostate specific membrane antigen (PSMA)-positron emission tomography (PET) using (68)Ga revolutionized prostate cancer imaging. Outperforming standard imaging, it allows complete staging of the local tumor and possible lymph nodes, visceral or bone metastases with high accuracy in only one examination (1,2). Sensitivities of 66% and specificities of 99% were observed for primary lymph node staging. Moreover, it has become an excellent staging tool for recurrent prostate cancer even at early stage and low PSA levels...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385796/harnessing-preclinical-molecular-imaging-to-inform-advances-in-personalized-cancer-medicine
#9
Peter Clark, Victoria A Ebiana, Laura Gosa, Timothy F Cloughesy, David A Nathanson
Comprehensive molecular analysis of individual tumors provides great potential for personalized cancer therapy. However, the presence of a specific genetic alteration is often insufficient to predict therapeutic efficacy. Drugs with distinct mechanisms of action can affect the biology of tumors in specific and unique ways. Therefore, assays that can measure drug-induced perturbations to defined functional tumor properties can be highly complementary to genomic analysis. Positron emission tomography (PET) provides the capacity to non-invasively measure the dynamics of various tumor biological processes in vivo...
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385795/-18-f-tetrafluoroborate-18-f-tfb-a-pet-probe-for-imaging-sodium-iodide-symporter-expression-whole-body-biodistribution-safety-and-radiation-dosimetry-in-thyroid-cancer-patients
#10
Jim O' Doherty, Maite Jauregui-Osoro, Teresa Brothwood, Teresa Szyszko, Paul Marsden, Michael O' Doherty, Gary Cook, Philip Blower, Val Lewington
Rationale: We report the safety, biodistribution and internal radiation dosimetry, in humans with thyroid cancer, of (18)F-tetrafluoroborate ((18)F-TFB), a novel PET radioligand for imaging the human sodium/iodide symporter (hNIS). Methods: Serial whole-body PET scans of 5 subjects with recently diagnosed with thyroid cancer were acquired prior to surgery for up to 4 hours after injection of 184 ± 15 MBq of (18)F-TFB. Activity was determined in whole blood, plasma and urine. Mean organ absorbed doses and effective doses were calculated via quantitative image analysis and using OLINDA/EXM software...
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385794/mri-and-pet-noninvasive-tools-to-probe-diffuse-intrinsic-pontine-glioma-biology
#11
Elizabeth Gerstner
No abstract text is available yet for this article.
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385793/reply-fact-sheet-about-interim-and-end-of-treatment-18-f-fdg-pet-ct-in-lymphoma
#12
Lale Kostakoglu
No abstract text is available yet for this article.
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385792/fixed-100-mci-i-131-activity-for-metastatic-thyroid-cancer-therapy-ignores-science-and-history
#13
Walter Jentzen, Alan E Nahum, Andreas Bockisch, Ina Binse, Mark Tulchinsky
No abstract text is available yet for this article.
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385791/reader-training-for-the-re-staging-of-biochemically-recurrent-prostate-cancer-using-fluciclovine-18-f-pet-ct
#14
Matthew P Miller, Lale Kostakoglu, Daniel Pryma, Jian Qin Yu, Albert Chau, Eric Perlman, Bonnie Clarke, Donald Rosen, Penelope Ward
Fluciclovine ((18)F) is a novel positron emission tomography (PET)/computerised tomography (CT) tracer. This blinded image evaluation (BIE) sought to demonstrate that, after limited training, readers naïve to fluciclovine ((18)F), could interpret fluciclovine ((18)F) images from subjects with biochemical recurrent (BCR) prostate cancer with acceptable diagnostic performance and reproducibility. The primary objectives were to establish individual readers' diagnostic performance and the overall interpretation (2/3 reader concordance) compared to standard of truth (SOT) data (histopathology and/or clinical follow-up) and to evaluate inter-reader reproducibility...
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28385790/reply-a-validation-study-of-automated-bone-scan-index-effect-on-reproducibility-due-to-the-procedural-variability-in-bone-scan-image-acquisition-a-common-mistake
#15
Aseem Undvall Anand, David Minarik
No abstract text is available yet for this article.
April 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28360212/correlation-of-18-f-fdg-pet-and-mr-apparent-diffusion-coefficient-adc-histogram-metrics-with-survival-in-diffuse-intrinsic-pontine-glioma-a-report-from-the-pediatric-brain-tumor-consortium
#16
Katherine Zukotynski, Sridhar Vajapeyam, Frederic H Fahey, Mehmet Kocak, Douglas Brown, Kelsey Ricci, Arzu Onar-Thomas, Maryam Fouladi, Tina Young Poussaint
Rationale: To describe baseline (18)F-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) voxel characteristics in pediatric diffuse intrinsic pontine glioma (DIPG) and to correlate these metrics with baseline magnetic resonance (MR) apparent diffusion coefficient (ADC) histogram metrics, progression-free survival (PFS) and overall survival (OS). Methods: Baseline brain FDG-PET and MR scans were obtained in 33 children from Pediatric Brain Tumor Consortium (PBTC) clinical DIPG trials. FDG-PET, post-gadolinium (PG) and ADC images were registered to baseline fluid attenuation inversion recovery (FLAIR) images...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28360211/quantitation-of-cancer-treatment-response-by-fdg-pet-ct-multi-center-assessment-of-measurement-variability
#17
Joo Hyun O, Heather A Jacene, Brandon Luber, Hao Wang, Jeff Leal, Minh-Huy Huynh, Richard L Wahl
To assess the inter-observer variability of quantitative F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters used in assessments of treatment response across multiple sites and readers. Methods: Paired pre- and post-treatment FDG PET/CT images of 30 oncologic patients were distributed to 22 readers across 15 United States and international sites. One reader was aware of the full medical history (readreference), while the 21 other readers were unaware. The readers selected the single "hottest tumor" from each study, and made standard uptake value (SUV) measurements from this target lesion and the liver...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28360210/learning-from-failure-hypoxia-is-an-evil-foe
#18
Rodney J Hicks
No abstract text is available yet for this article.
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28360209/preclinical-evaluation-of-rym1-a-novel-mmp-targeted-tracer-for-imaging-aneurysm
#19
Jakub Toczek, Yunpeng Ye, Kiran Gona, Hye-Yeong Kim, Jinah Han, Mahmoud Razavian, Reza Golestani, Jiasheng Zhang, Terence Wu, Jae-Joon Jung, Mehran Sadeghi
Matrix metalloproteinases (MMPs) play a key role in abdominal aortic aneurysm (AAA) development. Accordingly, MMP-targeted imaging provides important information regarding vessel wall biology in the course of aneurysm development. Given the small size of the vessel wall and its proximity with blood, molecular imaging of aneurysm optimally requires highly sensitive tracers with rapid blood clearance. To this end, we developed a novel hydrosoluble zwitterionic MMP inhibitor, RYM, based on which a pan-MMP tracer, RYM1, was designed...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28360208/prediction-of-response-to-immune-checkpoint-inhibitor-therapy-using-early-time-point-fdg-pet-ct-imaging-in-patients-with-advanced-melanoma
#20
Steve Y Cho, Evan J Lipson, Hyung-Jun Im, Steven P Rowe, Esther Mena, Amanda Blackford, Alin Chirindel, Drew M Pardoll, Suzanne L Topalian, Richard L Wahl
To evaluate (18)F-fluorodeoxyglucose-positron emission tomography/CT (FDG-PET/CT) scanning as an early predictor of response to immune checkpoint inhibitors (ICI) in patients with advanced melanoma. Methods: Twenty patients with advanced melanoma receiving ICI prospectively underwent FDG PET/CT at three scan intervals: prior to treatment initiation (SCAN-1), at days 21-28 (SCAN-2), and at 4 months (SCAN-3). This study was approved by the institutional review board, and informed consent was received from all patients who were enrolled between April 2012 and December 2013...
March 30, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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