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Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

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https://www.readbyqxmd.com/read/28302766/csf-clearance-in-alzheimer-disease-measured-with-dynamic-pet
#1
Mony J de Leon, Yi Li, Nobuyuki Okamura, Wai H Tsui, Les A Saint Louis, Lidia Glodzik, Ricardo S Osorio, Juan Fortea, Tracy Butler, Elizabeth Pirraglia, Silvia Fossati, Hee-Jin Kim, Roxana O Carare, Maiken Nedergaard, Helene Benveniste, Henry Rusinek
Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer's disease (AD) comes from primarily from rodent models. However, unlike rodents where predominant extra-cranial CSF egress is via olfactory nerves traversing the cribriform plate, human CSF clearance pathways are not well characterized. Using dynamic Positron Emission Tomography (PET) with (18)F-THK5117 a tracer for tau pathology, the ventricular CSF time activity was used as a biomarker for CSF clearance...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302765/letter-subjecting-radiologic-imaging-to-the-linear-no-threshold-hypothesis-a-non-sequitur
#2
Edward B Silberstein
No abstract text is available yet for this article.
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302764/-18-f-gp1-a-novel-fluorine-18-labeled-tracer-designed-for-pet-imaging-of-thrombi-with-high-detection-sensitivity-and-low-background
#3
Jessica Lohrke, Holger Siebeneicher, Markus Berger, Michael Reinhardt, Mathias Berndt, Andre Mueller, Marion Zerna, Norman Koglin, Felix Oden, Marcus Bauser, Matthias Friebe, Ludger M Dinkelborg, Joachim Huetter, Andrew W Stephens
Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks and pulmonary embolism are major causes of morbidity and mortality worldwide. GPIIb/IIIa is the key receptor involved in platelet aggregation and is a validated target for therapeutic approaches and diagnostic imaging. The aim of this study was to develop and characterize a specific small molecule tracer for positron emission tomography (PET) imaging that binds with high affinity to GPIIb/IIIa receptors and has suitable pharmacokinetic properties to overcome limitations of previous approaches...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302763/phase-2-study-of-99m-tc-trofolastat-spect-ct-to-identify-and-localize-prostate-cancer-in-intermediate-and-high-risk-patients-undergoing-radical-prostatectomy-and-extended-pelvic-lymph-node-dissection
#4
Karolien E Goffin, Steven Joniau, Peter Tenke, Kevin Slawin, Eric A Klein, Nancy Stambler, Thomas Strack, John Babich, Thomas Armor, Vivien Wong
Rationale:(99m)Tc-trofolastat ((99m)Tc-MIP-1404), a small-molecule inhibitor of prostate-specific membrane antigen (PSMA), shows high potential to detect prostate cancer (PCa) non-invasively using single-photon-emission-computed-tomography (SPECT). We therefore wanted to assess the performance of (99m)Tc-trofolastat SPECT/CT in a phase 2 multi-center, multi-reader prospective study in patients with intermediate- and high-grade PCa, prior to radical prostatectomy and extended pelvic lymph node dissection, with histopathology as gold standard...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302762/brain-fdg-pet-metabolic-abnormalities-in-macrophagic-myofasciitis-are-they-stable
#5
Paul Blanc-Durand, Axel Van Der Gucht, Mehdi Aoun Sebaiti, Mukedaisi Abulizi, Francois-Jérome Authier, Emmanuel Itti
We address this letter in addition to our recent published study (1). The aim is to add some insight to the evolution of the brain abnormalities that are observed with macrophagic myofasciitis (MMF). MMF is a chronic disease whom evolution is slow and symptoms first may occurs from months to year after a vaccination containing aluminium hydroxid adjuvants (2). Nevertheless, its evolution is not fully understood or known. MMF associated cognitive dysfunction (MACD) is based on a tripod combining dysexecutive syndrom, visual memory impairment and interhemispheric disconnection...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302761/performance-characteristics-of-the-whole-body-discovery-iq-pet-ct-system
#6
Gabriel Reynes-Llompart, Cristina Gámez-Cenzano, Inma Romero-Zayas, Laura Rodriguez-Bel, José Luís Vercher-Conejero, Josep M Martí-Climent
Purpose: The aim of this study was to assess the physical performance of a new PET/CT system Discovery IQ 5 Rings (General Electric, Milwaukee, WI). Methods: Performance measurements were obtained using the NEMA NU2-2012 methodology. Image quality was extended by accounting for different acquisition parameters (lesion-to-background ratios of 8:1, 4:1 and 2:1 and acquisition times) as well as different reconstruction algorithms (VPHD, VPHD-S and Q.Clear). Tomographic reconstruction was also assessed using a Jaszczak phantom...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302760/-11-c-pbr28-or-18-f-pbr111-detect-white-matter-inflammatory-heterogeneity-in-multiple-sclerosis
#7
Gourab Datta, Alessandro Colasanti, Nicola Kalk, David R Owen, Gregory Scott, Eugenii Ilan A Rabiner, Roger Gunn, Anne Lingford-Hughes, Omar Malik, Olga Ciccarelli, Richard Nicholas, Lei Nie, Marco Battaglini, Nicola De Stefano, Paul Matthews
Objective: To assess microglial activation in lesions and in normal appearing white matter of multiple sclerosis (MS) patients using positron emission tomography (PET). Methods: 34 MS patients (7 with secondary progressive MS (SPMS), 27 with relapsing remitting MS (RRMS)) and 30 healthy volunteers, genetically stratified for translocator protein (TSPO), binding status underwent PET scanning with TSPO radioligands ((11)C-PBR28 or (18)F-PBR111). Regional TSPO availability was measured as a distribution volume ratio (DVR) relative to the caudate (a pseudo-reference region)...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302759/preclinical-evaluation-of-11-c-sarcosine-as-a-substrate-of-proton-coupled-amino-acid-transporters-and-first-human-application-in-prostate-cancer
#8
Morand Piert, Xia Shao, David M Raffel, Mathew S Davenport, Jeffrey Montgomery, Lakshmi Kunju, Brian G Hockley, Javed Siddiqui, Peter J H Scott, Arul Chinnaiyan, Thekkelnaycke Rajandiran
Sarcosine is a known substrate of proton-coupled amino acid transporters (PAT), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness and progression. Methods: Carbon-11 radiolabeled sarcosine ((11)C-sarcosine) was tested as a new positron emission tomography (PET) imaging probe in comparison with (11)C-choline in two prostate cancer tumor xenograft models (DU-145 and PC-3)...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302758/atlas-of-spect-ct
#9
E Edmund Kim
No abstract text is available yet for this article.
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28302757/alteration-of-monoamine-receptor-activity-and-glucose-metabolism-in-paediatric-patients-with-anticonvulsant-induced-cognitive-impairment
#10
Yuankai Zhu, Jianhua Feng, Jianfeng Ji, Haifeng Hou, Lin Chen, Shuang Wu, Qing Liu, Qiong Yao, Peizhen Du, Kai Zhang, Qing Chen, Zexin Chen, Hong Zhang, Mei Tian
A landmark study from the Institute of Medicine (IOM) reported that the assessment of cognitive difficulties in children with epilepsy is timely and imperative. Anticonvulsant-induced cognitive impairment could influence the quality of life more than seizure itself in patients. Although monoaminergic system is involved in the regulation of cognitive process, its role in anticonvulsant-induced cognitive impairment remains unclear. Methods: To explore in vivo monoamine receptor binding activity in patients with anticonvulsant-induced cognitive impairment, each patient had PET imaging with both monoamine receptor binding agent, (11)C-N-methylspiperone ((11)C-NMSP), and glucose metabolic agent, (18)F-fluorodeoxyglucose ((18)F-FDG)...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28280223/progressive-disgregation-of-brain-networking-from-normal-aging-to-alzheimer-s-disease-independent-component-analysis-on-fdg-pet-data
#11
Marco Me Pagani, Alessandro Giuliani, Johanna Öberg, Fabrizio De Carli, Silvia Morbelli, Nicola Girtler, Francesca Bongioanni, Dario Arnaldi, Jennifer Accardo, Matteo Bauckneht, Andrea Chincarini, Gianmario Sambuceti, Cathrine Jonsson, Flavio Nobili
Brain connectivity has been assessed in several neurodegenerative disorders investigating the mutual correlations between pre-determined regions or nodes. The selective breakdown of brain networks during the progression from the normal aging (NA) to Alzheimer's Disease (AD) has also been observed. We implemented Independent Component Analysis (ICA) on 18F-FDG-PET data in five groups of subjects with cognitive state ranging from NA to AD dementia, including mild cognitive impairment patients not converting (ncMCI) and converting (MCI) to mild AD dementia, in order to disclose the spatial distribution of the independent components (ICs) in each cognitive state, and their accuracy in discriminating the groups...
March 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254874/qualification-of-nci-designated-cancer-centers-for-quantitative-pet-ct-imaging-in-clinical-trials
#12
Joshua S Scheuermann, Janet S Reddin, Adam Opanowski, Paul E Kinahan, Barry A Siegel, Lalitha K Shankar, Joel S Karp
The National Cancer Institute (NCI) developed the Centers for Quantitative Imaging Excellence (CQIE) initiative in 2010 to pre-qualify imaging facilities at all of the NCI-designated Comprehensive and Clinical Cancer Centers for oncology trials using advanced imaging techniques, including positron emission tomography (PET). This paper reviews the CQIE PET/CT (Computed Tomography) scanner qualification process and results in detail. Methods: Over a period of approximately 5 years, sites were requested to submit a variety of phantom, including uniform and ACR (American College of Radiology) phantoms, PET/CT images, as well as examples of clinical images...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254873/inter-and-intra-observer-agreement-of-fdg-pet-ct-image-interpretation-in-patients-referred-for-assessment-of-cardiac-sarcoidosis
#13
Hiroshi Ohira, Brian Mc Ardle, Robert A deKemp, Pablo B Nery, Daniel Juneau, Jennifer M Renaud, Ran Klein, Owen Clarkin, Karen MacDonald, Eugene Leung, Girish Nair, Rob S B Beanlands, David Birnie
Recent studies have reported the usefulness of (18)F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in aiding with the diagnosis and management of patients with cardiac sarcoidosis (CS). However, the image interpretation of FDG-PET for CS is sometimes challenging. We sought to investigate the inter- and intra-observer agreement and explore factors which lead to important discrepancies between readers. METHODS: We studied consecutive patients with no significant coronary artery disease who were referred for assessment of CS...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254872/pet-mri-for-oncological-brain-imaging-a-comparison-of-standard-mr-based-attenuation-corrections-with-a-novel-model-based-approach-for-the-siemens-mmr-pet-mr-system
#14
Ivo Rausch, Lucas Rischka, Claes N Ladefoged, Julia Furtner, Matthias Fenchel, Andreas Hahn, Rupert Lanzenberger, Marius E Mayerhoefer, Tatjana Traub-Weidinger, Thomas Beyer
To compare attenuation correction (AC) approaches for positron emission tomography/magnetic resonance imaging (PET/MRI) in clinical neuro-oncology. Methods: Forty-nine PET/MRI brain scans were included: brain tumor studies using (18)F-FET (n = 31) and 68-Ga-DOTANOC (n = 7) and studies of healthy subjects using (18)F-FDG (n = 11). For each subject, MR-based AC maps (MR-AC) were acquired using the standard DIXON- (DIXON) and UTE-based (UTE) approaches. A third MR-AC was calculated using a model-based, post-processing approach to account for bone attenuation values (BD, non-commercial prototype software by Siemens Healthcare)...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254871/linear-no-threshold-hypothesis-at-the-hospital-when-radioprotection-becomes-a-nosocomial-hazard
#15
Paolo Zanotti-Fregonara, Elif Hindie
No abstract text is available yet for this article.
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254870/interim-pet-in-hodgkin-lymphoma-is-it-so-useless
#16
Michel A Meignan, Anne-Segolene Cottereau, Benedicte Deau, Salim Kanoun, Alina Berriolo Riedinger, Olivier Casasnovas
No abstract text is available yet for this article.
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254869/phase-ii-study-of-a-radiotherapy-total-dose-increase-in-hypoxic-lesions-identified-by-f-miso-pet-ct-in-patients-with-non-small-cell-lung-carcinoma-rtep5-study
#17
Pierre Vera, Sébastien Thureau, Philippe Chaumet-Riffaud, Romain Modzelewski, Pierre Bohn, Maximilien Vermandel, Sébastien Hapdey, Amandine Pallardy, Marc-André Mahé, Marie Lacombe, Pierre Boisselier, Sophie Guillemard, Pierre Olivier, Véronique Beckendorf, Naji Salem, Nathalie Charrier, Enrique Chajon, Anne Devillers, Nicolas Aide, Serge Danhier, Fabrice Denis, Jean-Pierre Muratet, Etienne Martin, Alina Berriolo-Riedinger, Helène Kolesnikov-Gauthier, Eric Dansin, Carole Massabeau, Fredéric Courbon, Marie-Pierre Farcy-Jacquet, Pierre-Olivier Kotzki, Claire Houzard, Francoise Mornex, Laurent Vervueren, Amaury Paumier, Philippe Fernandez, Mathieu Salaun, Bernard Dubray
A multicenter phase II study investigated a selective radiotherapy (RT) dose increase to tumor areas with significant F-miso uptake in patients with non-small cell lung carcinoma (NSCLC). Methods: Eligible patients had locally advanced NSCLC, no contra-indication to concomitant chemo-radiotherapy (CCRT). The F-miso uptake on PET/CT was assessed by experts. If there was no uptake, 66 Gy was delivered. In F-miso-positive patients, the contours of the hypoxic area were transferred to the radiation oncologist. It was necessary for the radiotherapy dose to be as high as possible while fulfilling dose-limiting constraints for the spinal cord and lungs...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254868/resting-state-networks-as-simultaneously-measured-with-fmri-and-pet
#18
Alexandre Savio, Sarah Fünger, Masoud Tahmasian, Srinivas Rachakonda, Andrei Manoliu, Christian Sorg, Timo Grimmer, Vince Calhoun, Alexander Drzezga, Valentin Riedl, Igor Yakushev
Functional magnetic resonance imaging (fMRI) studies reported disruption of resting-state networks (RSNs) in a number of neuropsychiatric disorders. Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) captures neuronal activity that is in steady state at a longer time span and is less dependent of neuro-vascular coupling. Here, we aimed to identify RSNs in FDG-PET data and compare their spatial pattern with those obtained from simultaneously acquired resting state fMRI data in 22 middle-aged healthy subjects...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254867/randomized-trial-on-pet-ct-imaging-requires-adequate-follow-up
#19
Stefan Sauerland
No abstract text is available yet for this article.
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254866/proof-of-therapeutic-efficacy-of-a-novel-177-lu-labeled-neurotensin-receptor-1-antagonist-in-a-colon-carcinoma-xenograft-model
#20
Jörg Schulz, Martin Rohracker, Marvin Stiebler, Jürgen Goldschmidt, Franziska Stöber, Mercedes Noriega, Anette Pethe, Mathias Lukas, Frank Osterkamp, Ulrich Reineke, Aileen Höhne, Christiane Smerling, Holger Amthauer
Purpose: Increased expression of neurotensin receptor 1 (NTR1) has been shown in a large number of tumor entities like pancreatic or colon carcinoma. Hence, this receptor is a promising target for diagnostic imaging and radioligand therapy (RLT). Based on favorable biodistribution data of the NTR1-targeting agent (111)In-3BP 227, we investigated the therapeutic effect of its (177)Lu-labeled analog on the tumor growth of NTR1-positive HT29 colon carcinoma xenografts. Methods: 3BP 227 was labeled with (177)Lu...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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