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Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

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https://www.readbyqxmd.com/read/30237214/synthesis-and-preclinical-characterization-of-the-psma-targeted-hybrid-tracer-psma-i-f-for-nuclear-and-fluorescence-imaging-of-prostate-cancer
#1
Margret Schottelius, Alexander Wurzer, Katharina Wissmiller, Roswitha Beck, Maximilian Koch, Dimitrios Gkorpas, Johannes Notni, Tessa Buckle, Matthias N van Oosterom, Katja Steiger, Vasilis Ntziachristos, Markus Schwaiger, Fijs W B van Leeuwen, Hans-Jürgen Wester
The PSMA-targeted radiotracers 68 Ga/177 Lu-PSMA-I&T and 99m Tc-PSMA-I&S are currently successfully employed for clinical PET imaging, radionuclide therapy and radioguided surgery of metastatic prostate cancer. To additionally exploit the high sensitivity and spatial resolution of fluorescence imaging for improved surgical guidance, a first PSMA-I&T-based hybrid tracer, PSMA-I&F (DOTAGA-k(Sulfo-Cy5)-y-nal-k-Sub-KuE), has been developed and evaluated. The in vitro PSMA-targeting efficiency of PSMA-I&F, the reference PSMA-I&T and their corresponding natGa-/68 Ga- and natLu/177 Lu-counterparts was determined in LNCaP cells via competitive binding assays (IC50), dual-tracer radioligand- and fluorescence internalization studies...
September 20, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30237213/production-of-15-o-for-medical-applications-via-the-16-o-%C3%AE-n-15-o-reaction
#2
Stacy L Queern, Ryan Cardman, Christopher S Loveless, Matthew R Shepherd, Suzanne E Lapi
Oxygen-15 (t1/2 = 122 s) is a useful radionuclide for Positron Emission Tomography (PET) applications. Current production of 15 O typically makes use of the 14 N(d,n)15 O, 15 N(p,n)15 O or 16 O(p,pn)15 O reactions using an accelerator. A novel approach for the production of 15 O is via the 16 O(γ,n)15 O reaction using an electron linear accelerator (eLINAC). Photonuclear reactions using an eLINAC may allow for feasible and economical production of 15 O compared to the current methods. Methods : In this work, experiments using a repurposed Clinac were conducted using oxygen-containing alumina as a target material to study the production rate of 15 O...
September 20, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30237212/evaluation-of-111-in-dota-5d3-a-surrogate-spect-imaging-agent-for-radioimmunotherapy-of-prostate-specific-membrane-antigen
#3
Sangeeta Ray Banerejee, Vivek Kumar, Ala Lisok, Donika Plyku, Zora Nováková, Bryan Wharram, Mary Brummet, Cyril Barinka, Robert F Hobbs, Martin G Pomper
BACKGROUND: 5D3 is a new high-affinity murine monoclonal antibody specific for prostate-specific membrane antigen (PSMA). PSMA is a target for the imaging and therapy of prostate cancer. 111 In-Labeled antibodies have been used as surrogates for 177 Lu/90 Y-labeled therapeutics. We characterized 111 In-DOTA-5D3 by SPECT-CT imaging, tissue biodistribution studies and dosimetry. METHODS: Radiolabeling, stability, cell uptake, and internalization of 111 In-DOTA-5D3 were performed by established techniques. Biodistribution and SPECT imaging were done in male non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice bearing human PSMA(+) PC3 PIP and PSMA(-) PC3 flu prostate cancer xenografts on the upper right and left flanks, respectively at 2, 24, 48, 72 and 192 h post-injection...
September 20, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30237211/-18-f-fdg-pet-ct-for-systemic-staging-of-newly-diagnosed-breast-cancer-in-men
#4
Gary A Ulaner, Jessica Juarez, Christopher Riedl, Deborah Goldman
18 F-FDG PET/CT has demonstrated substantial value in systemic staging of newly diagnosed breast cancer in women. However, it is not known whether breast cancer in male patients benefit similarly. This study assesses 18 F-FDG PET/CT systemic staging in patients with newly diagnosed male breast cancer and determines detection rates for unsuspected distant metastases stratified by pre-PET/CT stage. Methods: In this Institutional Review Board-approved retrospective study, our Healthcare Information System was screened for stage I-III male patients with breast cancer who underwent 18 F-FDG PET/CT prior to systemic or radiation therapy from 2004 to 2017...
September 20, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30237210/a-proof-of-concept-study-to-inhibit-abcg2-and-abcb1-mediated-efflux-transport-at-the-human-blood-brain-barrier
#5
Martin Bauer, Rudolf Karch, Beatrix Wulkersdorfer, Cecile Philippe, Lukas Nics, Eva-Maria Klebermass, Maria Weber, Stefan Poschner, Helmuth Haslacher, Walter Jäger, Nicolas Tournier, Wolfgang Wadsak, Marcus Hacker, Markus Zeitlinger, Oliver Langer
ABCB1 and ABCG2 are two efflux transporters at the blood-brain barrier (BBB) which effectively restrict brain distribution of dual ABCB1/ABCG2 substrate drugs, such as tyrosine kinase inhibitors. Pharmacological inhibition of ABCB1/ABCG2 may improve the efficacy of dual substrate drugs for treatment of brain tumors, but no marketed ABCB1/ABCG2 inhibitors are currently available. In the present study, we examined the potential of supratherapeutic-dose oral erlotinib to inhibit ABCB1/ABCG2 activity at the human BBB...
September 20, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30213849/affibody-based-pet-imaging-to-guide-egfr-targeted-cancer-therapy-in-head-and-neck-squamous-cell-cancer-models
#6
Thomas A Burley, Chiara Da Pieve, Carlos D Martins, Daniela M Ciobota, Louis Allott, Wim J G Oyen, Kevin J Harrington, Graham Smith, Gabriela Kramer-Marek
In head and neck squamous cell carcinoma (HNSCC), the human epidermal growth factor receptor 1 (EGFR) is the dominant signaling molecule among all members of the family. So far, cetuximab is the only approved anti-EGFR mAb used for the treatment of HNSCC, but despite the benefits of adding it to standard treatment regimens, attempts to define a predictive biomarker to stratify patients for cetuximab treatment have been unsuccessful. We hypothesized that imaging with EGFR-specific radioligands may facilitate non-invasive measurement of EGFR expression across the entire tumor burden and also allow for dynamic monitoring of cetuximab-mediated changes in receptor expression...
September 13, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30213848/three-hour-delayed-imaging-improves-assessment-of-coronary-18-f-sodium-fluoride-pet
#7
Jacek Kwiecinski, Daniel S Berman, Sang-Eun Lee, Damini Dey, Sebastien Cadet, Martin L Lassen, Guido Germano, Maurits A Jansen, Marc R Dweck, David E Newby, Hyuk-Jae Chang, Mijin Yun, Piotr Slomka
Coronary 18 F-sodium fluoride (18 F-NaF) PET imaging identifies ruptured plaques in patients with recent myocardial infarction and localizes to atherosclerotic lesions with active calcification. Most studies to date performed the PET acquisition 1-hour (1h) post-injection. Although qualitative and semi-quantitative analysis is feasible with 1h images, often residual blood pool activity makes it difficult to discriminate plaques with 18 F-NaF uptake from noise. We aimed to assess whether delayed 3-hour (3h) post-injection PET scan improves image quality and uptake measurements...
September 13, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30213847/optimizing-longitudinal-%C3%AE-amyloid-pet-measurement-the-challenges-of-intensity-normalization
#8
Susan Marie Landau
No abstract text is available yet for this article.
September 13, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30213846/evaluation-of-a-novel-pet-radioligand-to-image-o-glcnacase-in-brain-and-periphery-of-rhesus-monkey-and-knock-out-mouse
#9
Soumen Paul, Mohammad B Haskali, Jeih-San Liow, Sami S Zoghbi, Vanessa N Barth, Marcy Comly Kolodrubetz, Michelle R Bond, Cheryl L Morse, Robert L Gladding, Michael P Frankland, Nancy Kant, Lawrence Slieker, Sergey Shcherbinin, Hugh N Nuthall, Paolo Zanotti-Fregonara, John A Hanover, Cynthia Jesudason, Victor W Pike, Robert B Innis
Accumulation of hyper-phosphorylated tau, a microtubule-associated protein, plays an important role in the progression of Alzheimer's disease (AD). Animal studies suggest that one strategy for treating AD and related tauopathies may be inhibition of O-GlcNAcase (OGA), which may subsequently decrease pathological tau phosphorylation Here, we report the pharmacokinetics of a novel positron emission tomography (PET) radioligand, 18 F-LSN3316612, which binds with high affinity and selectivity to OGA. Methods: PET imaging was performed in rhesus monkeys at baseline and after administration of either thiamet G, a potent OGA inhibitor, or nonradioactive LSN3316612...
September 13, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30213845/response-to-nuclear-medicine-procedures-do-not-pose-cancer-risks-in-women-unappreciated-or-otherwise
#10
Anat Biegon, Dinko Franceschi, Mark Schweitzer
No abstract text is available yet for this article.
September 13, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30190306/current-treatment-strategies-in-metastasized-differentiated-thyroid-cancer
#11
Michael Kreissl, Marcel Janssen, James Nagarajah
On successful completion of this activity one should be able to (1) judge the prognosis of patients harboring metastasized differentiated thyroid cancer (2) identify suitable treatment regimens taking into account the characteristics of the tumor and the patient's general condition, (3) know the basics of radioiodine treatment, TKI treatment and redifferentiation treatment for metastasized DTC.
September 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30190305/amyloid-load-a-more-sensitive-biomarker-for-amyloid-imaging
#12
Alex Whittington, Roger N Gunn
Amyloid-β (Aβ) plays a key role in the pathogenesis of Alzheimer's disease (AD) and it can be imaged in vivo using [18 F]-AV45 positron emission tomography (PET). The mean cortical standardised uptake value ratio (SUVr) is a commonly used outcome measure for quantifying the global Aβ burden however the sensitivity is sub-optimal which can lead to low power in clinical trials. We introduce amyloid load, AβL as a novel biomarker to quantify the global Aβ burden along with an automated algorithm for its calculation (IQA )...
September 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30190304/interobserver-agreement-for-the-standardized-reporting-system-psma-rads-1-0-on-18-f-dcfpyl-pet-ct-imaging
#13
Rudolf A Werner, Ralph A Bundschuh, Lena Bundschuh, Mehrbod S Javadi, Jeffrey P Leal, Takahiro Higuchi, Kenneth J Pienta, Andreas K Buck, Martin G Pomper, Michael A Gorin, Constantin Lapa, Steven P Rowe
Objectives: Recently, the standardized reporting and data system for prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging studies, termed PSMA-RADS version 1.0, was introduced. We aimed to determine the interobserver agreement for applying PSMA-RADS to imaging interpretation of 18 F-DCFPyL PET examinations in a prospective setting mimicking the typical clinical work-flow at a prostate cancer referral center. Methods: Four readers (two experienced readers (ER, > 3 years of PSMA-targeted PET interpretation experience) and two inexperienced readers (IR, < 1 year of experience)), who had all read the initial publication on PSMA-RADS 1...
September 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30190303/follow-up-of-lesions-with-equivocal-radiotracer-uptake-on-psma-targeted-pet-in-patients-with-prostate-cancer-predictive-values-of-the-psma-rads-3a-and-psma-rads-3b-categories
#14
Yafu Yin, Rudolf A Werner, Takahiro Higuchi, Constantin Lapa, Kenneth J Pienta, Martin G Pomper, Michael A Gorin, Steven P Rowe
Purpose: Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging has become commonly utilized in patients with prostate cancer (PCa). The PSMA reporting and data system version 1.0 (PSMA-RADS version 1.0) categorizes lesions on the basis of the likelihood of PCa involvement, with PSMA-RADS-3A (soft tissue) and PSMA-RADS-3B (bone) lesions being indeterminate for the presence of disease. We retrospectively reviewed the imaging follow-up of such lesions to determine the rate at which they underwent changes suggestive of underlying PCa...
September 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30166358/prognostic-value-of-sur-in-patients-with-trimodality-treatment-of-locally-advanced-esophageal-carcinoma
#15
Rebecca Bütof, Frank Hofheinz, Klaus Zöphel, Julia Schmollack, Christina Jentsch, Sebastian Zschaeck, Jörg Kotzerke, Jörg van den Hoff, Michael Baumann
The prognosis of patients with esophageal carcinoma remains dismal despite ongoing efforts to improve treatment options. For locally advanced tumors, several randomized trials have shown the benefit of neoadjuvant chemoradiation followed by surgery compared to surgery alone. The aim of this exploratory study was to evaluate the prognostic value of different baseline positron emission tomography (PET) parameters and their potentially additional prognostic impact at the end of neoadjuvant radiochemotherapy. Furthermore, the standard uptake ratio (SUR) as a new parameter for quantification of tumor metabolism was compared to the conventional PET parameters metabolic active volume (MTV), total lesion glycolysis (TLG), and standardized uptake value (SUV) taking into account known basic parameters...
August 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30166357/dixon-vibe-deep-learning-divide-pseudo-ct-synthesis-for-pelvis-pet-mr-attenuation-correction
#16
Angel Torrado-Carvajal, Javier Vera-Olmos, David Izquierdo-Garcia, Onofrio Antonio Catalano, Manuel Antonio Morales, Justin Margolin, Andrea Soricelli, Marco Salvatore, Norberto Malpica, Ciprian Catana
Whole-body attenuation correction (AC) is still challenging in combined PET/MR scanners. We describe Dixon-VIBE Deep Learning (DIVIDE), a deep learning network architecture that allows synthesizing pelvis pseudo-CT maps based only on the standard Dixon volumetric interpolated breath-hold examination (Dixon-VIBE) images currently acquired for AC in commercial Siemens scanners. Methods: We propose a network that performs a mapping between the four 2D Dixon MRI images (water, fat, in- and out-of-phase) and their corresponding 2D CT image...
August 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30166356/reply-semi-quantification-limitations-fmtvdm%C3%A2-%C3%A2-demonstrates-quantified-tumor-response-to-treatment-with-both-regional-blood-flow-and-metabolic-changes
#17
Olivier Humbert, Francois Brunotte, Alexandre Cochet
No abstract text is available yet for this article.
August 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30166355/synthesis-of-patient-specific-transmission-image-for-pet-attenuation-correction-for-pet-mr-imaging-of-the-brain-using-a-convolutional-neural-network
#18
Karl D Spuhler, John Gardus, Yi Gao, Christine DeLorenzo, Ramin Parsey, Chuan Huang
Attenuation correction is a notable challenge associated with simultaneous PET/MRI, particularly in neuroimaging, where sharp boundaries between air and bone volumes exist. This leads to concerns regarding the visual and, more specifically, quantitative accuracy of PET reconstructions for data obtained with PET/MRI. Recently developed techniques can synthesize attenuation maps using only MRI data and are likely adequate for clinical use, however, little work has been conducted to assess their suitability for the dynamic PET studies frequently employed in research to derive physiological information such as binding potential of neuroreceptors in a region...
August 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30166354/nuclear-medicine-procedures-do-not-pose-cancer-risks-in-women-unappreciated-or-otherwise
#19
Jeffry A Siegel, Bennett S Greenspan, Edward B Silberstein, Bill Sacks, Carol S Marcus, Michael G Stabin
No abstract text is available yet for this article.
August 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30166353/the-relationship-between-tumour-glucose-metabolism-and-host-systemic-inflammatory-responses-in-patients-with-cancer-a-systematic-review
#20
Ross D Dolan, Naomi G McLees, Ahmer Irfan, Stephen T McSorley, Paul G Horgan, David Colville, Donald C McMillan
Introduction: One of the most important and long recognised characteristics of tumour cells is their dysregulated cellular energetics with anaerobic driven glucose uptake. In patients with cancer the prognostic value of the systemic inflammatory response has been well established and the recent combination of PET and CT scanning combines the assessment of tumour physiological activity with detailed anatomical localisation. The aim of this study was to carry out a systematic review of the assessment of the relationship between both the tumour and host inflammatory responses using PETCT...
August 30, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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