journal
MENU ▼
Read by QxMD icon Read
search

Journal of Neurotrauma

journal
https://www.readbyqxmd.com/read/28537530/titrating-the-dose-of-oxygen-after-severe-traumatic-brain-injury-in-the-era-of-precision-medicine
#1
Patrick M Kochanek, Hulya Bayir
n/a.
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28537493/the-relationship-between-cerebral-vasoreactivity-and-post-concussive-symptom-severity
#2
Tamadher Albalawi, Jason W Hamner, Matthew Lapointe, William Meehan, Can Ozan Tan
While pathophysiology underlying post-concussion symptom burden is unknown, data suggest that cerebrovascular dysfunction may be among the culprits. We sought to determine whether the degree of impairment in the ability of cerebrovasculature to buffer against changes in arterial gases (vasoreactivity) is associated with concussion symptoms. In 15 participants (19±5 years, 1 week to 1 year post-injury) diagnosed with concussion, we assessed vasoreactivity from the slope of the linear relationship of beat-by-beat middle cerebral artery blood flow velocity (transcranial Doppler ultrasound) to end-tidal CO<sub>2</sub> during progressive increases in end-tidal CO<sub>2</sub> (air rebreathing)...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28537464/multi-domain-assessment-of-autonomic-function-in-spinal-cord-injury-using-a-modified-autonomic-reflex-screen
#3
Michael James Berger, Kurt Kimpinski, Katharine Dianne Currie, Hirmand Nouraei, Mahsa Sadeghi, Andrei V Krassioukov
The purpose of this study was to characterize autonomic lesions in participants with spinal cord injury (SCI; n=10) using an autonomic reflex screen, incorporating sudomotor, cardiovagal and sympathetic adrenergic tests, as well as hemodynamic responses to head-up tilt (HUT). Hemodynamic responses were compared to healthy controls (n=20) and previously published normative cutoffs in order better identify autonomic impairments. Sympathetic skin responses (SSRs), heart rate response to deep breathing (HRDB) and heart rate and beat-to-beat blood pressure responses to Valsalva maneuver (VM) and HUT were measured...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28447870/does-specialized-inpatient-rehabilitation-affect-whether-or-not-people-with-traumatic-spinal-cord-injury-return-home
#4
Christiana L Cheng, Tova Plashkes, Tian Shen, Nader Fallah, Suzanne Humphreys, Colleen O'Connell, A Gary Linassi, Chester Ho, Christine Short, Karen Ethans, Rebecca Charbonneau, Jérôme Paquet, Vanessa K Noonan
Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, and to determine if such rehabilitation improved the likelihood of returning home. This cohort study utilized data from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) to identify patients with tSCI discharged from 1 of 18 participating acute specialized spine facilities between 2011 and 2015 to either 1 of 13 participating specialized rehabilitation facilities, or to another discharge destination...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28381134/head-impact-density-a-model-to-explain-the-elusive-concussion-threshold
#5
Steven P Broglio, Andrew Lapointe, Kathryn L O'Connor, Michael McCrea
Concussion is a heterogeneous injury occurring throughout a range of impact magnitudes. Consequently, research focusing on a single or set of variables at the time of injury to understand concussive biomechanics has been thwarted by low injury prediction sensitivity. The current study examined the role of Impact Density in estimating concussive injury risk. Head impact data were collected across seven high school football seasons with the Head Impact Telemetry System (HIT System). Over the study period, 29 concussions were included for data analysis...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28376700/frontal-traumatic-brain-injury-increases-impulsive-decision-making-in-rats-a-potential-role-for-the-inflammatory-cytokine-interleukin-12
#6
Cole Vonder Haar, Kris M Martens, Lara-Kirstie Riparip, Susanna Rosi, Cheryl L Wellington, Catharine A Winstanley
Traumatic brain injury (TBI) is associated with the development of numerous psychiatric diseases. Of particular concern for TBI patients is the impact of chronic impulsivity on daily functioning. Despite the scope of the human problem, little has been done to address impulsivity in animal models of brain injury. In the current study, we examined the effects of either a severe or a milder bilateral frontal controlled cortical impact injury on impulsivity using the Delay Discounting Task (DDT), in which preference for smaller-sooner over larger-later rewards is indicative of greater impulsive choice...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28351230/continuous-monitoring-and-visualization-of-optimum-spinal-cord-perfusion-pressure-in-patients-with-acute-cord-injury
#7
Suliang Chen, Peter Smielewski, Marek Czosnyka, Marios C Papadopoulos, Samira Saadoun
The optimum spinal cord perfusion pressure (SCPP) after traumatic spinal cord injury (TSCI) is unknown. Here, we describe techniques to compute and display the optimum SCPP in real time. We recruited adults within 72 h of severe TSCI (American Spinal Injuries Association [ASIA] grades A-C). A pressure probe and a microdialysis catheter were placed on the injured cord. SCPP was computed as mean arterial pressure (MAP) minus intraspinal pressure (ISP), spinal pressure reactivity index (sPRx) as the running ISP/MAP correlation coefficient, and continuous optimum SCPP (cSCPPopt) as the SCPP that minimizes sPRx in a moving 4-h window...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28335684/bone-marrow-derived-endothelial-progenitor-cell-treatment-in-a-model-of-lateral-fluid-percussion-injury-in-rats-evaluation-of-acute-and-subacute-outcome-measures
#8
Eugene Park, Katya Park, Elaine Liu, Rongcai Jiang, Jianning Zhang, Andrew J Baker
Traumatic brain injury (TBI) continues to be a serious health care issue while therapies to treat TBI remain elusive. Promising results from the use of endothelial progenitor cells (EPCs) in numerous disease states highlight the pleiotropic capacity of this cell type. We have previously demonstrated that EPC-conditioned media reduces axonal degeneration subsequent to in vitro oxygen-glucose deprivation insult and concurrently improves white matter and microvascular outcome in vivo after mid-line fluid percussion injury...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28520505/early-blockade-of-matrix-metalloproteinases-in-spinal-cord-injured-dogs-results-in-a-long-term-increase-in-bladder-compliance
#9
Jonathan Michael Levine, Noah D Cohen, Thomas Fandel, Gwendolyn Joan Levine, Joseph M Mankin, John F Griffin, Sharon C Kerwin, C Elizabeth Boudreau, Alpa Trivedi, Linda Noble-Haeusslein
Spinal cord injury (SCI) is often accompanied by reduced bladder compliance, which contributes to adverse conditions including urinary tract infections and vesicoureteral reflux. Reduced compliance is, in part, attributed to extensive remodeling of the bladder wall including the extracellular matrix (ECM). Here we tested the hypothesis that blockade of matrix metalloproteinases (MMPs), known for their ability to remodel the ECM, improves bladder compliance in dogs with SCI. We first evaluated dogs with naturally occurring SCIs resulting from intervertebral disc herniation (IVDH)...
May 18, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28462633/rural-and-urban-living-in-persons-with-spinal-cord-injury-and-comparing-environmental-barriers-their-health-and-quality-of-life-outcomes
#10
R Andrew Glennie, Juliet Batke, Nader Fallah, Christiana L Cheng, Carly S Rivers, Vanessa K Noonan, Marcel F Dvorak, Charles G Fisher, Brian K Kwon, John T Street
There is worldwide geographic variation in the epidemiology of traumatic spinal cord injury (tSCI). The aim of this study was to determine whether environmental barriers, health status, and quality-of-life outcomes differ between patients with tSCI living in rural or urban settings, and whether patients move from rural to urban settings after tSCI. A cohort review of the Rick Hansen SCI Registry (RHSCIR) was undertaken from 2004 to 2012 for one province in Canada. Rural/urban setting was determined using postal codes...
May 18, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28514188/the-invisibility-of-mild-traumatic-brain-injury-impaired-cognitive-performance-as-a-silent-symptom
#11
Leore R Heim, Miaad Badar, Shahaf Edut, Lital Rachmany, Renana Baratz, Ran Lin, Aviya Elpaz, Doaa Qubty, Lior Bikovski, Vardit Rubovitch, Shaul Schreiber, Chaim G Pick
The present study was designed to tackle two notorious features of mild Traumatic Brain Injury (mTBI) - heterogeneity and invisibility - by characterizing the full scope of mTBI symptoms. Mice were exposed to brain injuries of different intensities utilizing a weight-drop model (10, 30, 50, and 70g), and subsequently subjected to a comprehensive battery of behavioral tests at different time points, and immunohistochemical examination of cortical slices. While the physiological, neurological, emotional, and motor function of mTBI mice, i...
May 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28437224/structure-process-and-culture-of-intensive-care-units-treating-patients-with-severe-traumatic-brain-injury-survey-of-centers-participating-in-the-american-college-of-surgeons-trauma-quality-improvement-program
#12
Aziz S Alali, Victoria A McCredie, Todd G Mainprize, David Gomez, Avery B Nathens
Outcome after severe traumatic brain injury (TBI) differs substantially between hospitals. Explaining this variation begins with understanding the differences in structures and processes of care, particularly at intensive care units (ICUs) where acute TBI care takes place. We invited trauma medical directors (TMDs) from 187 centers participating in the American College of Surgeons Trauma Quality Improvement Program (ACS TQIP) to complete a survey. The survey domains included ICU model, type, availability of specialized units, staff, training programs, standard protocols and order sets, approach to withdrawal of life support, and perceived level of neurosurgeons' engagement in the ICU management of TBI...
May 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28335664/cognitive-behavioral-intervention-compared-to-telephone-counseling-early-after-mild-traumatic-brain-injury-a-randomized-trial
#13
Myrthe E Scheenen, Annemarie C Visser-Keizer, Myrthe E de Koning, Harm J van der Horn, Peter van de Sande, Marlies van Kessel, Joukje van der Naalt, Jacoba M Spikman
Many patients do not return to work (RTW) after mild traumatic brain injury (mTBI) because of persistent complaints that are often resistant to therapy in the chronic phase. Recent studies suggest that psychological interventions should be implemented early post-injury to prevent patients from developing chronic complaints. This study is a randomized, controlled trial that examines the effectiveness of a newly developed cognitive behavioral therapy (CBT) intervention (CBTi) compared to telephonic counseling (TC) in at-risk mTBI patients (patients with high reports of early complaints)...
May 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28330412/early-asymmetric-cardio-cerebral-causality-and-outcome-after-severe-traumatic-brain-injury
#14
Lei Gao, Peter Smielewski, Marek Czosnyka, Ari Ercole
The brain and heart are two vital systems in health and disease, increasingly recognized as a complex, interdependent network with constant information flow in both directions. After severe traumatic brain injury (TBI), the causal, directed interactions between the brain, heart, and autonomic nervous system have not been well established. Novel methods are needed to probe unmeasured, potentially prognostic information in complex biological networks that are not revealed by traditional means. In this study, we examined potential bidirectional causality between intracranial pressure (ICP), mean arterial pressure (MAP), and heart rate (HR) and its relationship to mortality in a 24-h period early post-TBI...
May 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28493787/impact-of-therapy-on-recovery-during-rehabilitation-in-patients-with-traumatic-spinal-cord-injury
#15
Catherine Truchon, Nader Fallah, Argelio Santos, Joëlle Vachon, Vanessa K Noonan, Christiana L Cheng
Evidence-based planning of rehabilitation interventions is important to improving cost efficiency while maintaining patient and system outcomes. This paper aims to explore the relationship between rehabilitation therapy, functional outcome, bed utilization, and care costs after traumatic spinal cord injury (tSCI). A retrospective review of 262 persons with tSCI admitted to an inpatient rehabilitation facility from 2005-2011 was conducted. Treatment variables and outcome measures included length of stay (LOS), days to rehabilitation (onset), hours and intensity of therapy, and Functional Independence Measure (FIM)...
May 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28490277/il-33-promotes-recruitment-of-microglia-macrophages-in-response-to-traumatic-brain-injury
#16
Grzegorz Wicher, Ulrika Wallenquist, Ying Lei, Mattias Enoksson, Xiaofei Li, Barbara Fuchs, Sami Abu Hamdeh, Niklas Marklund, Lars Hillered, Gunnar Nilsson, Karin Forsberg-Nilsson
Traumatic brain injury (TBI) is a devastating condition, often leading to life-long consequences for the patients. Even though modern neurointensive care has improved functional and cognitive outcomes, efficient pharmacological therapies are still lacking. Targeting peripherally derived, or resident inflammatory cells that are rapid responders to brain injury is promising, but complex, since the contribution of inflammation to exacerbation versus improved recovery varies with time after injury. The injury-induced inflammatory response is triggered by release of alarmins, and in the present study we asked if Interleukin-33 (IL-33), an injury-associated nuclear alarmin, is involved in TBI...
May 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28490228/concussion-mechanisms-and-activities-in-youth-high-school-and-college-football
#17
Robert C Lynall, Kody R Campbell, Erin B Wasserman, Thomas P Dompier, Zack Kerr
Our purpose was to determine concussion mechanism and activity differences between 3 cohorts of football players; youth, high school, and college. Participants in this prospective cohort study included youth (ages 5-14, 118 teams, 310 team-seasons), high school (96 teams, 184 team-seasons), and college (34 teams, 71 team-seasons) football players. Athletic trainers collected athlete-exposure (AE) and concussion data during the 2012-2014 seasons. Injury mechanism referred to the object that made contact with the concussed player, resulting in the concussion...
May 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28490224/prevalence-of-abnormal-magnetic-resonance-imaging-findings-in-children-with-persistent-symptoms-after-pediatric-sports-related-concussion
#18
Robert H Bonow, Seth D Friedman, Francisco A Perez, Richard G Ellenbogen, Samuel R Browd, Christine L MacDonald, Monica S Vavilala, Frederick P Rivara
A subset of patients experience persistent symptoms after pediatric concussion, and magnetic resonance imaging (MRI) is commonly used to evaluate for pathology. The utility of this practice is unclear. We conducted a retrospective cohort study to describe the MRI findings in children with concussion. A registry of all patients seen at our institution from January 2010 through March 2016 with pediatric sports-related concussion was cross-referenced with a database of radiographic studies. Radiology reports were reviewed for abnormal findings...
May 10, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28486883/monitoring-of-optimal-cerebral-perfusion-pressure-in-traumatic-brain-injured-patients-using-a-multi-window-weighting-algorithm
#19
Xiuyun Liu, Natasha M Maurits, Marcel J H Aries, Marek Czosnyka, Ari Ercole, Joseph Donnelly, Danilo Cardim, Dong-Joo Kim, Celeste Dias, Manuel Cabeleira, Peter Smieleweski
Methods to identify an autoregulation guided 'optimal' cerebral perfusion pressure (CPPopt) for traumatic brain injury patients (TBI) have been reported through several studies. An important drawback of existing methodology is that CPPopt can be calculated only in approximately 50-60% of the monitoring time. In this study, we hypothesized that the CPPopt yield and the continuity can be improved significantly through application of a multi-window and weighting calculation algorithm, without adversely affecting preservation of its prognostic value...
May 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28486051/characterization-of-differences-in-functional-connectivity-associated-with-close-range-blast-exposure
#20
Meghan Robinson, Dustin Clark, William Milberg, Regina McGlinchey, David Salat
Despite the prevalence of blast injuries in recent overseas conflicts, our knowledge of their impact on neural health is lacking. We have recently published work demonstrating differences in functional magnetic resonance imaging (fMRI) connectivity that were specific to close-range blast exposure (CBE), as opposed to other prevalent military-related factors. Here, we replicate this finding in an independent sample of 135 Veterans, again finding that CBE, regardless of concussion, is predictive of persistent changes in brain physiology...
May 9, 2017: Journal of Neurotrauma
journal
journal
20162
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"