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JOURNAL ARTICLE
Jing Jing, Zhe Zhang, Lei Su, Chenyang Gao, Ai Guo, Xinyao Liu, Huabing Wang, Xinghu Zhang, Yaou Liu, Giancarlo Comi, Emmanuelle Waubant, Fu-Dong Shi, De-Cai Tian
BACKGROUND: Although trigeminal nerve involvement is a characteristic of multiple sclerosis (MS), its prevalence across studies varies greatly due to MRI resolution and cohort selection bias. The mechanism behind the site specificity of trigeminal nerve injury is still unclear. We aim to determine the prevalence of trigeminal nerve involvement in patients with MS in a consecutive 7T brain MRI cohort. METHODS: This observational cohort originates from an ongoing China National Registry of Neuro-Inflammatory Diseases...
March 7, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#22
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 5, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#23
JOURNAL ARTICLE
Federico De Santis, Michele Romoli, Matteo Foschi, Francesco Domenico Sciancalepore, Lucio D'Anna, Lorenzo Barba, Samir Abu-Rumeileh, Simona Sacco, Raffaele Ornello
BACKGROUND: Leisure-time physical activity (LTPA) protects against vascular diseases. Whether and to what extent different levels of LTPA, including lower ones, benefit stroke prevention is still unclear. METHODS: We searched prospective cohort studies, indexed on PubMed and Scopus, published in English up to 22 April 2023, that investigated, in a general healthy population, the relationship between different predefined LTPA levels, compared with inactivity, and the risk of any type of stroke...
March 5, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#24
JOURNAL ARTICLE
Natalia Hernandez Poblete, Florian Gay, Francesco Salvo, Jean-Arthur Micoulaud-Franchi, Thomas Bienvenu, Julien Coelho, Jerome Aupy
BACKGROUND: How epilepsy surgery influences the bidirectional relationship of epilepsy and depression remains poorly defined. METHOD: For a better understanding of this question, we conducted a systematic review and meta-analysis of risk ratio on depression prevalence before and after epilepsy surgery, using Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Three databases were comprehensively screened for all studies assessing depression before and after resective surgery in adult epileptic patients until 8 October 2022...
March 5, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#25
JOURNAL ARTICLE
Vittorio Velucci, Sarah Idrissi, Roberta Pellicciari, Marcello Esposito, Assunta Trinchillo, Daniele Belvisi, Giovanni Fabbrini, Gina Ferrazzano, Carmen Terranova, Paolo Girlanda, Giovanni Majorana, Vincenzo Rizzo, Francesco Bono, Giovanni Idone, Vincenzo Laterza, Laura Avanzino, Francesca Di Biasio, Roberta Marchese, Anna Castagna, Marina Ramella, Christian Lettieri, Sara Rinaldo, Maria Concetta Altavista, Luigi Polidori, Laura Bertolasi, Maria Chiara Tozzi, Roberto Erro, Paolo Barone, Pierangelo Barbero, Roberto Ceravolo, Marcello Mario Mascia, Tommaso Ercoli, Antonella Muroni, Carlo Alberto Artusi, Maurizio Zibetti, Cesa Lorella Maria Scaglione, Anna Rita Bentivoglio, Maria Sofia Cotelli, Luca Magistrelli, Giovanni Cossu, Alberto Albanese, Giovanna Maddalena Squintani, Tommaso Schirinzi, Angelo Fabio Gigante, Luca Maderna, Roberto Eleopra, Antonio Pisani, Daniela Cassano, Marcello Romano, Marina Rizzo, Alfredo Berardelli, Giovanni Defazio
BACKGROUND: Several earlier studies showed a female predominance in idiopathic adult-onset dystonia (IAOD) affecting the craniocervical area and a male preponderance in limb dystonia. However, sex-related differences may result from bias inherent to study design. Moreover, information is lacking on whether sex-related differences exist in expressing other dystonia-associated features and dystonia spread. OBJECTIVE: To provide accurate information on the relationship between sex differences, motor phenomenology, dystonia-associated features and the natural history of IAOD...
March 1, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#26
REVIEW
Peter Walter Barry, Kate Kelley, Toni Tan, Ilora Finlay
In 2021, the National Institute for Health and Care Excellence produced an evidence-based guideline on the diagnosis and management of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a disabling long-term condition of unknown cause. The guideline provides clear support for people living with ME/CFS, their families and carers, and for clinicians. A recent opinion piece published in the journal suggested that there were anomalies in the processing and interpretation of the evidence when developing the guideline and proposed eight areas where these anomalies were thought to have occurred...
February 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#27
REVIEW
Martin Langeskov-Christensen, Erika Franzén, Lars Grøndahl Hvid, Ulrik Dalgas
Parkinson's disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while pharmacological symptomatic treatments have limited effects in certain domains and cause side effects. Identification of interventions that prevent, slow, halt or mitigate the disease is therefore pivotal. Exercise is safe and represents a cornerstone in PD rehabilitation, but exercise may have even more fundamental benefits that could change clinical practice...
February 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#28
JOURNAL ARTICLE
Young Gi Min, Yeji Moon, Young Nam Kwon, Byung Joo Lee, Kyung-Ah Park, Jae Yong Han, Jinu Han, Haeng-Jin Lee, Seol-Hee Baek, Byung-Jo Kim, Jun-Soon Kim, Kyung Seok Park, Nam-Hee Kim, Martha Kim, Tai-Seung Nam, Seong-Il Oh, Jae Ho Jung, Jung-Joon Sung, Myoung-Jin Jang, Seong-Joon Kim, Sung-Min Kim
BACKGROUND: Optic neuritis (ON) prognosis is influenced by various factors including attack severity, underlying aetiologies, treatments and consequences of previous episodes. This study, conducted on a large cohort of first ON episodes, aimed to identify unique prognostic factors for each ON subtype, while excluding any potential influence from pre-existing sequelae. METHODS: Patients experiencing their first ON episodes, with complete aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibody testing, and clinical data for applying multiple sclerosis (MS) diagnostic criteria, were enrolled...
February 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#29
JOURNAL ARTICLE
Ryo Otani, Kazumoto Shibuya, Yo-Ichi Suzuki, Tomoki Suichi, Marie Morooka, Yuya Aotsuka, Moeko Ogushi, Satoshi Kuwabara
BACKGROUND: Increased 'cortical' and 'peripheral' excitability are reportedly associated with shorter survival in amyotrophic lateral sclerosis (ALS) patients, suggesting that hyperexcitability contributes to motor neuron death. However, whether upper or lower motor function has a greater impact on survival is unclear. We aimed to investigate the component that strongly impacts the prognosis of ALS. METHODS: A total of 103 consecutive patients with ALS who underwent cortical (threshold tracking transcranial magnetic stimulation (TMS)) and motor nerve excitability tests were included...
February 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#30
JOURNAL ARTICLE
Simon Witzel, Veronika Micca, Hans P Müller, André Huss, Franziska Bachhuber, Johannes Dorst, Dorothée E Lulé, Hayrettin Tumani, Jan Kassubek, Albert C Ludolph
BACKGROUND: Validation of the 2020 consensus criteria for primary lateral sclerosis (PLS) is essential for their use in clinical practice and future trials. METHODS: In a large cohort of patients diagnosed with PLS by expert opinion prior to the new criteria with detailed clinical baseline evaluation (n=107) and longitudinal follow-up (n=63), we applied the new diagnostic criteria and analysed the clinical phenotype, electromyography (EMG), diagnostic accuracy and prognosis, adding neurofilaments and MRI as potential biomarkers...
February 22, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#31
JOURNAL ARTICLE
Moritz Steinruecke, Isabel Mason, Mairi Keen, Laura McWhirter, Alan J Carson, Jon Stone, Ingrid Hoeritzauer
BACKGROUND: Functional neurological disorder (FND) is characterised by neurological symptoms, such as seizures and abnormal movements. Despite its significance to patients, the clinical features of chronic pain in people with FND, and of FND in people with chronic pain, have not been comprehensively studied. METHODS: We systematically reviewed PubMed, Embase and PsycINFO for studies of chronic pain in adults with FND and FND in patients with chronic pain. We described the proportions of patients reporting pain, pain rating and timing, pain-related diagnoses and responsiveness to treatment...
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#32
JOURNAL ARTICLE
Valeria Pozzilli, Shalom Haggiag, Massimiliano Di Filippo, Fioravante Capone, Vincenzo Di Lazzaro, Carla Tortorella, Claudio Gasperini, Luca Prosperini
BACKGROUND: Seizures are reported to be more prevalent in individuals with multiple sclerosis (MS) compared with the general population. Existing data predominantly originate from population-based studies, which introduce variability in methodologies and are vulnerable to selection and reporting biases. METHODS: This meta-analysis aims to assess the incidence of seizures in patients participating in randomised clinical trials and to identify potential contributing factors...
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#33
EDITORIAL
John P Ioannidis
No abstract text is available yet for this article.
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#34
JOURNAL ARTICLE
Thiago Junqueira Ribeiro Rezende, Isaac Adanyaguh, Orlando G P Barsottini, Benjamin Bender, Fernando Cendes, Leo Coutinho, Andreas Deistung, Imis Dogan, Alexandra Durr, Juan Fernandez-Ruiz, Sophia L Göricke, Marina Grisoli, Carlos R Hernandez-Castillo, Christophe Lenglet, Caterina Mariotti, Alberto R M Martinez, Breno K Massuyama, Fanny Mochel, Lorenzo Nanetti, Anna Nigri, Sergio E Ono, Gülin Öz, José Luiz Pedroso, Kathrin Reetz, Matthis Synofzik, Helio Teive, Sophia I Thomopoulos, Paul M Thompson, Dagmar Timmann, Bart P C van de Warrenburg, Judith van Gaalen, Marcondes C França, Ian H Harding
BACKGROUND: Spinal cord damage is a feature of many spinocerebellar ataxias (SCAs), but well-powered in vivo studies are lacking and links with disease severity and progression remain unclear. Here we characterise cervical spinal cord morphometric abnormalities in SCA1, SCA2, SCA3 and SCA6 using a large multisite MRI dataset. METHODS: Upper spinal cord (vertebrae C1-C4) cross-sectional area (CSA) and eccentricity (flattening) were assessed using MRI data from nine sites within the ENIGMA-Ataxia consortium, including 364 people with ataxic SCA, 56 individuals with preataxic SCA and 394 nonataxic controls...
February 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#35
JOURNAL ARTICLE
Elba Pascual-Goñi, Roger Collet, Clara Tejada-Illa, Lorena Martín-Aguilar, Marta Caballero-Ávila, Cinta Lleixà, Silvana Novelli, Jordi López-Pardo, Albert Esquirol Sanfeliu, Anais Mariscal, Yolanda Álvaro Gargallo, Eugenia Martínez-Hernández, Dolores Cocho, Luis Querol
BACKGROUND: Intravenous immunoglobulin (IVIG) and rituximab are considered the first-line and second-line treatments for Chronic Ataxic Neuropathy and Ophthalmoplegia with IgM-paraprotein, cold Agglutinins, and anti-Disialosyl antibodies (CANOMAD), with an overall clinical response around 50%. New anti-CD38 daratumumab, targeting long-lived plasma cells, has been reported as a promising therapy for treatment-refractory antibody-mediated disorders. We report the first case of a severe refractory CANOMAD, successfully treated with daratumumab...
February 10, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#36
JOURNAL ARTICLE
Helena Sandoval-Insausti, Mario H Flores-Torres, Kjetil Bjornevik, Marianna Cortese, Albert Y Hung, Michael Schwarzschild, Tian-Shin Yeh, Alberto Ascherio
BACKGROUND: Flavonoids have been proposed to reduce the risk of Parkinson's disease (PD). However, results from epidemiological studies have been inconclusive. OBJECTIVE: To prospectively examine the association between the intake of flavonoids and their subclasses and the risk of PD and how pesticides may confound or modify that association. METHODS: The study population comprised 80 701 women (1984-2016) and 48 782 men (1986-2016) from two large US cohorts...
February 6, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#37
JOURNAL ARTICLE
Adrià Macias-Gómez, Joan Jiménez-Balado, Isabel Fernández-Pérez, Antoni Suárez-Pérez, Marta Vallverdú-Prats, Leopoldo Guimaraens, Elio Vivas, Jesus Saldaña, Eva Giralt-Steinhauer, Daniel Guisado-Alonso, Gloria Villalba, Maria-Pilar Gracia, Manel Esteller, Ana Rodriguez-Campello, Jordi Jiménez-Conde, Angel Ois, Elisa Cuadrado-Godia
BACKGROUND: We aimed to investigate the association between DNA-methylation biological age (B-age) calculated as age acceleration (ageAcc) and key aneurysmal subarachnoid haemorrhage (aSAH) complications such as vasospasm, delayed cerebral ischaemia (DCI), poor outcome, and mortality. METHODS: We conducted a prospective study involving 277 patients with aSAH. B-age was determined in whole blood samples using five epigenetic clocks: Hannum's, Horvath's, Levine's and both versions of Zhang's clocks...
February 1, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#38
JOURNAL ARTICLE
Christoph Linnemann, Carlo Wilke, David Mengel, Henrik Zetterberg, Carolin Heller, Jens Kuhle, Arabella Bouzigues, Lucy L Russell, Phoebe H Foster, Eve Ferry-Bolder, John Cornelis Van Swieten, Lize C Jiskoot, Harro Seelaar, Fermin Moreno, Barbara Borroni, Raquel Sánchez-Valle, Daniela Galimberti, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James Benedict Rowe, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Chris R Butler, Alexander Gerhard, Simon Ducharme, Isabelle L E Ber, Pietro Tiraboschi, Isabel Santana, Florence Pasquier, Johannes Levin, Markus Otto, Sandro Sorbi, Jonathan Daniel Rohrer, Matthis Synofzik
BACKGROUND: Blood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to facilitate the use of NfL in gFTD multicentre trials by testing its (1) reliability across labs; (2) reliability to stratify gFTD disease stages; (3) comparability between blood matrices and (4) stability across recruiting sites. METHODS: Comparative analysis of blood NfL levels in a large gFTD cohort (GENFI) for (1)-(4), with n=344 samples (n=148 presymptomatic, n=11 converter, n=46 symptomatic subjects, with mutations in C9orf72 , GRN or MAPT ; and n=139 within-family controls), each measured in three different international labs by Simoa HD-1 analyzer...
February 1, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#39
REVIEW
Vijay Patel, Paul Edison
A growing body of evidence suggests that cardiometabolic risk factors play a significant role in Alzheimer's disease (AD). Diabetes, obesity and hypertension are highly prevalent and can accelerate neurodegeneration and perpetuate the burden of AD. Insulin resistance and enzymes including insulin degrading enzymes are implicated in AD where breakdown of insulin is prioritised over amyloid-β. Leptin resistance and inflammation demonstrated by higher plasma and central nervous system levels of interleukin-6 (IL-6), IL-1β and tumour necrosis factor-α, are mechanisms connecting obesity and diabetes with AD...
January 30, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#40
JOURNAL ARTICLE
Ganesha Liyanage, Benjamin P Trewin, Joseph A Lopez, Jane Andersen, Fiona Tea, Vera Merheb, Kristy Nguyen, Fiona X Z Lee, Marzena J Fabis-Pedrini, Alicia Zou, Ali Buckland, Anthony Fok, Michael H Barnett, Stephen W Reddel, Romain Marignier, Aseel El Hajj, Mastura Monif, Anneke van der Walt, Jeannette Lechner-Scott, Allan G Kermode, Tomas Kalincik, Simon A Broadley, Russell C Dale, Sudarshini Ramanathan, Fabienne Brilot
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) IgG seropositivity is a prerequisite for MOG antibody-associated disease (MOGAD) diagnosis. While a significant proportion of patients experience a relapsing disease, there is currently no biomarker predictive of disease course. We aim to determine whether MOG-IgG epitopes can predict a relapsing course in MOGAD patients. METHODS: MOG-IgG-seropositive confirmed adult MOGAD patients were included (n=202). Serum MOG-IgG and epitope binding were determined by validated flow cytometry live cell-based assays...
January 30, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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