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LETTER
Paolo Amami, Sara Prioni, Marco Fusar Poli, Riccardo Pascuzzo, Elisa Bocchi, Nico Golfrè Andreasi, Grazia Devigili, Roberto Cilia, Sara Rinaldo, Vincenzo Levi, Francesco Ghielmetti, Marina Grisoli, Marco Gemma, Francesco DiMeco, Roberto Eleopra, Sylvie Piacentini
No abstract text is available yet for this article.
April 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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JOURNAL ARTICLE
Zixiao Yin, Tianshuo Yuan, Anchao Yang, Yichen Xu, Guanyu Zhu, Qi An, Ruoyu Ma, Yifei Gan, Lin Shi, Yutong Bai, Ning Zhang, Chunxue Wang, Yin Jiang, Fangang Meng, Wolf-Julian Neumann, Huiling Tan, Jian-Guo Zhang
BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the most common sleep problems and represents a key prodromal marker in Parkinson's disease (PD). It remains unclear whether and how basal ganglia nuclei, structures that are directly involved in the pathology of PD, are implicated in the occurrence of RBD. METHOD: Here, in parallel with whole-night video polysomnography, we recorded local field potentials from two major basal ganglia structures, the globus pallidus internus and subthalamic nucleus, in two cohorts of patients with PD who had varied severity of RBD...
April 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#3
JOURNAL ARTICLE
Hannah A Hagy, Maureen Lacy, Nataliya Turchmanovych-Hienkel, Jon E Grant, Daniel Biro, Peter C Warnke
BACKGROUND: MRI guided laser interstitial thermal therapy (M-LITT) capsulotomy has proven to be efficacious in decreasing refractory obsessive-compulsive disorder (OCD) related symptomatology yet capsulotomy either via radiosurgery or radiofrequency ablation has in some patients led to increased apathy following surgery. The current case series aims to investigate objective patient-reported change in apathy, disinhibition, depression, and executive dysfunction following anterior capsulotomy via M-LITT for OCD...
April 16, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#4
JOURNAL ARTICLE
Thomas D Parker, Chris Hardy, Sarah Keuss, William Coath, David M Cash, Kirsty Lu, Jennifer M Nicholas, Sarah-Naomi James, Carole Sudre, Sebastian Crutch, Doris-Eva Bamiou, Jason D Warren, Nick C Fox, Marcus Richards, Jonathan M Schott
BACKGROUND: Hearing loss has been proposed as a modifiable risk factor for dementia. However, the relationship between hearing, neurodegeneration, and cognitive change, and the extent to which pathological processes such as Alzheimer's disease and cerebrovascular disease influence these relationships, is unclear. METHODS: Data from 287 adults born in the same week of 1946 who underwent baseline pure tone audiometry (mean age=70.6 years) and two time point cognitive assessment/multimodal brain imaging (mean interval 2...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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JOURNAL ARTICLE
James B Badenoch, Alvar Paris, Benjamin Meir Jacobs, Alastair J Noyce, Charles R Marshall, Sheena Waters
BACKGROUND: Depression is reported as a risk factor, prodromal feature and late consequence of Parkinson's disease (PD). We aimed to evaluate the timing, neuroanatomy and prognostic implications of depression in PD. METHODS: We used data from 434 023 participants from UK Biobank with 14.1 years of follow-up. Multivariable regression models established associations of depression with incident PD and regional brain volumes. Cox proportional hazards models assessed prognostic associations of depression in PD with incident dementia and all-cause mortality...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#6
JOURNAL ARTICLE
Angeliki G Filippatou, Yana Said, Haiwen Chen, Eleni S Vasileiou, Gelareh Ahmadi, Elias S Sotirchos
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a demyelinating disorder of the central nervous system. We aimed to evaluate the diagnostic performance of recently proposed MOGAD diagnostic criteria in a real-world patient cohort at a tertiary referral centre. METHODS: We identified all patients who were evaluated at Johns Hopkins and were MOG-IgG seropositive by cell-based assay. We retrospectively applied the proposed MOGAD diagnostic criteria...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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JOURNAL ARTICLE
Katherine Phillips, Krishnarajah Nirantharakumar, Benjamin R Wakerley, Francesca L Crowe
BACKGROUND: Migraine is common in women of reproductive age. This study aimed to (1) describe the prevalence of migraine in pregnant women in the UK, (2) identify drugs commonly prescribed for migraine during pregnancy and (3) identify characteristics associated with being prescribed medication for migraine during pregnancy. METHODS: The Clinical Practice Research Datalink pregnancy register, a database of pregnancy episodes identified in anonymised primary care health records, was used...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#8
JOURNAL ARTICLE
Mie Reith Mahler, Melinda Magyari, Luigi Pontieri, Frederik Elberling, Rolf Pringler Holm, Arkadiusz Weglewski, Mai Bang Poulsen, Lars Kristian Storr, Plamen Anzhelov Bekyarov, Zsolt Illes, Matthias Kant, Tobias Sejbaek, Morten Leif Stilund, Peter V Rasmussen, Maria Brask, Inga Urbonaviciute, Finn Sellebjerg
BACKGROUND: Clinicians frequently rely on relapse counts, T2 MRI lesion load (T2L) and Expanded Disability Status Scale (EDSS) scores to guide treatment decisions for individuals diagnosed with multiple sclerosis (MS). This study evaluates how these factors, along with age and sex, influence prognosis during treatment with teriflunomide (TFL). METHODS: We conducted a nationwide cohort study using data from the Danish Multiple Sclerosis Registry.Eligible participants had relapsing-remitting MS or clinically isolated syndrome and initiated TFL as their first treatment between 2013 and 2019...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#9
JOURNAL ARTICLE
Cathérine Dekeyser, Matthias Hautekeete, Melissa Cambron, Vincent Van Pesch, Francesco Patti, Jens Kuhle, Samia Khoury, Jeanette Lechner Scott, Oliver Gerlach, Alessandra Lugaresi, Davide Maimone, Andrea Surcinelli, Pierre Grammond, Tomas Kalincik, Mario Habek, Barbara Willekens, Richard Macdonell, Patrice Lalive, Tunde Csepany, Helmut Butzkueven, Cavit Boz, Valentina Tomassini, Matteo Foschi, José Luis Sánchez-Menoyo, Ayse Altintas, Saloua Mrabet, Gerardo Iuliano, Maria Jose Sa, Raed Alroughani, Rana Karabudak, Eduardo Aguera-Morales, Orla Gray, Koen de Gans, Anneke van der Walt, Pamela A McCombe, Norma Deri, Justin Garber, Abdullah Al-Asmi, Olga Skibina, Pierre Duquette, Elisabetta Cartechini, Daniele Spitaleri, Riadh Gouider, Aysun Soysal, Liesbeth Van Hijfte, Mark Slee, Maria Pia Amato, Katherine Buzzard, Guy Laureys
BACKGROUND: It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course. METHODS: This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis...
April 3, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#10
LETTER
Ryul Kim, Seohee Choi, Nyeonju Kang, Kiwon Park, Heehyun Shin, Hanall Lee, Hyungwoo Lee, Jin-Sun Jun, Beomseok Jeon, Kyeongho Byun
No abstract text is available yet for this article.
March 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#11
JOURNAL ARTICLE
Niels J M Verstegen, Ruth R Hagen, Christine Kreher, Lisan H Kuijper, Jet van den Dijssel, Thomas Ashhurst, Laura Y L Kummer, Virginia Palomares Cabeza, Maurice Steenhuis, Mariël C Duurland, Rivka de Jongh, C Ellen van der Schoot, Veronique A L Konijn, Erik Mul, Katherine Kedzierska, Koos P J van Dam, Eileen W Stalman, Laura Boekel, Gertjan Wolbink, Sander W Tas, Joep Killestein, Theo Rispens, Luuk Wieske, Taco W Kuijpers, Filip Eftimov, Zoé L E van Kempen, S Marieke van Ham, Anja Ten Brinke, Carolien E van de Sandt
BACKGROUND: Messenger RNA (mRNA) vaccines provide robust protection against SARS-CoV-2 in healthy individuals. However, immunity after vaccination of patients with multiple sclerosis (MS) treated with ocrelizumab (OCR), a B cell-depleting anti-CD20 monoclonal antibody, is not yet fully understood. METHODS: In this study, deep immune profiling techniques were employed to investigate the immune response induced by SARS-CoV-2 mRNA vaccines in untreated patients with MS (n=21), OCR-treated patients with MS (n=57) and healthy individuals (n=30)...
March 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#12
JOURNAL ARTICLE
Raph Goldacre, Michael Trubshaw, Eva J A Morris, Kevin Talbot, Michael J Goldacre, Alexander Guy Thompson, Martin R Turner
BACKGROUND: Venous thromboembolism (VTE) can occur in amyotrophic lateral sclerosis (ALS) and pulmonary embolism causes death in a minority of cases. The benefits of preventing VTE must be weighed against the risks. An accurate estimate of the incidence of VTE in ALS is crucial to assessing this balance. METHODS: This retrospective record-linkage cohort study derived data from the Hospital Episode Statistics database, covering admissions to England's hospitals from 1 April 2003 to 31 December 2019 and included 21 163 patients with ALS and 17 425 337 controls...
March 28, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#13
JOURNAL ARTICLE
Tomas Kalincik, Sifat Sharmin, Izanne Roos, Jennifer Massey, Ian Sutton, Barbara Withers, Mark S Freedman, Harold Atkins, Eva Krasulova, Eva Kubala Havrdova, Marek Trneny, Tomas Kozak, Joachim Burman, Richard Macdonell, Øivind Torkildsen, Lars Bø, Anne Kristine Lehmann, Basil Sharrack, John Snowden
BACKGROUND: Natalizumab was not shown to modify disability in progressive multiple sclerosis (MS). This matched observational study compared the effectiveness of autologous haematopoietic stem cell transplantation (AHSCT) with natalizumab in progressive MS. METHODS: Patients with primary/secondary progressive MS from seven AHSCT MS centres and the MSBase registry, treated with AHSCT or natalizumab, were matched on a propensity score derived from sex, age, Expanded Disability Status Scale (EDSS), number of relapses 12/24 months before baseline, time from MS onset, the most effective prior therapy and country...
March 27, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#14
JOURNAL ARTICLE
John Vissing, Sari Atula, Mari Savolainen, Juha Mehtälä, Laila Mehkri, Tina Bech Olesen, Tero Ylisaukko-Oja, Ingrid Lindberg-Schager, Fredrik Berggren, Fredrik Piehl
BACKGROUND: Incidence and prevalence rates of myasthenia gravis (MG) vary considerably across studies, and mortality risk is rarely addressed. We examined the prevalence and incidence rates, mortality and factors associated with mortality with MG. METHOD: This was a registry linkage study based on nationwide health and administrative registries of Denmark, Finland and Sweden (populations of 5.9, 5.6 and 10.5 million, respectively). Patients with MG were identified based on International Classification of Diseases codes from inpatient and outpatient specialised care registries...
March 27, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#15
JOURNAL ARTICLE
Anna Joseph, Gaston Baslet, Mary A O'Neal, Ginger Polich, Irene Gonsalvez, Andrea N Christoforou, Barbara A Dworetzky, Primavera A Spagnolo
BACKGROUND: Functional neurological disorder (FND) is a common and disabling neuropsychiatric condition, which disproportionally affects women compared with men. While the etiopathogenesis of this disorder remains elusive, immune dysregulation is emerging as one potential mechanism. To begin to understand the role of immune dysfunctions in FND, we assessed the prevalence of several common autoimmune diseases (ADs) in a large cohort of patients with FND and examined the influence of psychiatric comorbidities and biological sex...
March 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#16
JOURNAL ARTICLE
Dror Shir, Nick Corriveau-Lecavalier, Camilo Bermudez Noguera, Leland Barnard, Nha Trang Thu Pham, Hugo Botha, Joseph R Duffy, Heather M Clark, Rene L Utianski, David S Knopman, Ronald C Petersen, Bradley F Boeve, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, Dennis W Dickson, Gregory S Day, Walter K Kremers, Neill R Graff-Radford, David T Jones, Mary M Machulda, Julie A Fields, Jennifer L Whitwell, Keith A Josephs, Jonathan Graff-Radford
BACKGROUND: Primary progressive aphasia (PPA) defines a group of neurodegenerative disorders characterised by language decline. Three PPA variants correlate with distinct underlying pathologies: semantic variant PPA (svPPA) with transactive response DNA-binding protein of 43 kD (TDP-43) proteinopathy, agrammatic variant PPA (agPPA) with tau deposition and logopenic variant PPA (lvPPA) with Alzheimer's disease (AD). Our objectives were to differentiate PPA variants using clinical and neuroimaging features, assess progression and evaluate structural MRI and a novel 18-F fluorodeoxyglucose positron emission tomography (FDG-PET) image decomposition machine learning algorithm for neuropathology prediction...
March 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#17
JOURNAL ARTICLE
Jie Ma, Jia-Jia Wu, Xiang-Xin Xing, Xin Xue, Yun-Ting Xiang, Xiao-Min Zhen, Jian-Hua Li, Juan-Juan Lu, Jun-Peng Zhang, Mou-Xiong Zheng, Xu-Yun Hua, Jian-Guang Xu
BACKGROUND: This study aimed to investigate the efficacy of circuits-based paired associative stimulation (PAS) in adults with amnestic mild cognitive impairment (aMCI). METHODS: We conducted a parallel-group, randomised, controlled clinical trial. Initially, a cohort of healthy subjects was recruited to establish the cortical-hippocampal circuits by tracking white matter fibre connections using diffusion tensor imaging. Subsequently, patients diagnosed with aMCI, matched for age and education, were randomly allocated in a 1:1 ratio to undergo a 2-week intervention, either circuit-based PAS or sham PAS...
March 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#18
JOURNAL ARTICLE
Yi Chao Foong, Daniel Merlo, Melissa Gresle, Katherine Buzzard, Michael Zhong, Wei Zhen Yeh, Vilija Jokubaitis, Mastura Monif, Olga Skibina, Serkan Ozakbas, Francesco Patti, Pierre Grammond, Maria Pia Amato, Tomas Kalincik, Dana Horakova, Eva Kubala Havrdova, Bianca Weinstock-Guttman, Jeanette Lechner Scott, Cavit Boz, Maria Jose Sa, Helmut Butzkueven, Anneke van der Walt, Chao Zhu
BACKGROUND: Ongoing controversy exists regarding optimal management of disease modifying therapy (DMT) in older people with multiple sclerosis (pwMS). There is concern that the lower relapse rate, combined with a higher risk of DMT-related infections and side effects, may alter the risk-benefit balance in older pwMS. Given the lack of pwMS above age 60 in randomised controlled trials, the comparative efficacy of high-efficacy DMTs such as ocrelizumab has not been shown in older pwMS. We aimed to evaluate the comparative effectiveness of ocrelizumab, a high-efficacy DMT, versus interferon/glatiramer acetate (IFN/GA) in pwMS over the age of 60...
March 7, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#19
JOURNAL ARTICLE
Tiphaine Saulnier, Margherita Fabbri, Mélanie Le Goff, Catherine Helmer, Anne Pavy-Le Traon, Wassilios G Meissner, Olivier Rascol, Cecile Proust-Lima, Alexandra Foubert-Samier
BACKGROUND: Health-related quality of life (Hr-QoL) scales provide crucial information on neurodegenerative disease progression, help improve patient care and constitute a meaningful endpoint for therapeutic research. However, Hr-QoL progression is usually poorly documented, as for multiple system atrophy (MSA), a rare and rapidly progressing alpha-synucleinopathy. This work aimed to describe Hr-QoL progression during the natural course of MSA, explore disparities between patients and identify informative items using a four-step statistical strategy...
March 7, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#20
LETTER
Raquel Sainz-Amo, Jessenia Morillo-González, Jorge Gómez-Corral, Cristina Moreno, Araceli Alonso Cánovas, Juan Carlos Martinez Castrillo, Mark J Edwards, Daniel Hernández-Huerta, Isabel Pareés
No abstract text is available yet for this article.
March 7, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
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