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Journal of Neurology, Neurosurgery, and Psychiatry

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https://www.readbyqxmd.com/read/29142146/inflammatory-natalizumab-associated-pml-baseline-characteristics-lesion-evolution-and-relation-with-pml-iris
#1
Mike P Wattjes, Martijn T Wijburg, Jeroen van Eijk, Stephan Frequin, Bernard M J Uitdehaag, Frederik Barkhof, Clemens Warnke, Joep Killestein
BACKGROUND AND OBJECTIVE: Natalizumab-associated progressive multifocal leukoencephalopathy (NTZ-PML) patients may show imaging signs suggestive of inflammation at diagnosis ('inflammatory PML'), reminiscent of PML-immune reconstitution inflammatory syndrome (PML-IRIS). We investigated the imaging characteristics of inflammatory NTZ-PML lesions and PML-IRIS to determine differentiating and overlapping features. METHODS: We scored the presence, localisation and pattern of imaging characteristics of inflammation on brain MRI scans of inflammatory NTZ-PML patients...
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142145/clinical-course-therapeutic-responses-and-outcomes-in-relapsing-mog-antibody-associated-demyelination
#2
Sudarshini Ramanathan, Shekeeb Mohammad, Esther Tantsis, Tina Kim Nguyen, Vera Merheb, Victor S C Fung, Owen Bruce White, Simon Broadley, Jeannette Lechner-Scott, Steve Vucic, Andrew P D Henderson, Michael Harry Barnett, Stephen W Reddel, Fabienne Brilot, Russell C Dale
OBJECTIVE: We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. METHODS: We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. RESULTS: The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children...
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142144/plasma-creatinine-a-potential-prognostic-biomarker-in-amyotrophic-lateral-sclerosis
#3
EDITORIAL
Steve Vucic
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142143/dha-supplementation-improves-cognitive-function-via-enhancing-a%C3%AE-mediated-autophagy-in-chinese-elderly-with-mild-cognitive-impairment-a-randomised-placebo-controlled-trial
#4
Yan-Ping Zhang, Yinyin Lou, Jing Hu, Rujuan Miao, Fei Ma
BACKGROUND: Higher docosahexaenoic acid (DHA) intake is inversely correlated with relative risk of Alzheimer's disease. The potential benefits of DHA supplementation in people with mild cognitive impairment (MCI) have not been fully examined. OBJECTIVE: Our study aimed to assess the effect of a 24-month DHA supplementation on cognitive function and amyloid beta (Aβ)-mediated autophagy in elderly subjects with MCI. METHODS: This was a randomised, double-blind, placebo-controlled trial in Tianjin, China...
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142142/purkinje-cell-cytoplasmic-antibody-type-i-anti-yo-predictive-of-gastrointestinal-adenocarcinomas-in-men
#5
LETTER
Jenny Linnoila, Yong Guo, Avi Gadoth, Aditya Raghunathan, Becky Parks, Andrew McKeon, Claudia F Lucchinetti, Vanda A Lennon, Sean J Pittock
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142141/pragmatic-approach-to-muscle-mri-biomarkers-in-motor-neuron-disease
#6
EDITORIAL
Neil G Simon
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142140/imaging-and-csf-analyses-effectively-distinguish-cjd-from-its-mimics
#7
Peter Rudge, Harpreet Hyare, Alison Green, John Collinge, Simon Mead
OBJECTIVE: To review clinical and investigation findings in patients referred to a specialist prion clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alternative final diagnosis. METHODS: Review the clinical findings and investigations in 214 patients enrolled into the UK National Prion Monitoring Cohort Study between October 2008 and November 2015 who had postmortem confirmed sCJD and compare these features with 50 patients referred over the same period who had an alternative final diagnosis (CJD mimics)...
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142139/multidisciplinary-clinic-for-functional-movement-disorders-fmd-1-year-experience-from-a-single-centre
#8
LETTER
Alexandra E Jacob, Courtney A Smith, Megan E Jablonski, Abbey R Roach, Kathy M Paper, Darryl L Kaelin, Diane Stretz-Thurmond, Kathrin LaFaver
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29142138/chitotriosidase-chit1-is-increased-in-microglia-and-macrophages-in-spinal-cord-of-amyotrophic-lateral-sclerosis-and-cerebrospinal-fluid-levels-correlate-with-disease-severity-and-progression
#9
Petra Steinacker, Federico Verde, Lubin Fang, Emily Feneberg, Patrick Oeckl, Sigrun Roeber, Sarah Anderl-Straub, Adrian Danek, Janine Diehl-Schmid, Klaus Fassbender, Klaus Fliessbach, Hans Foerstl, Armin Giese, Holger Jahn, Jan Kassubek, Johannes Kornhuber, G Bernhard Landwehrmeyer, Martin Lauer, Elmar Hans Pinkhardt, Johannes Prudlo, Angela Rosenbohm, Anja Schneider, Matthias L Schroeter, Hayrettin Tumani, Christine A F von Arnim, Jochen Weishaupt, Patrick Weydt, Albert C Ludolph, Deniz Yilmazer Hanke, Markus Otto
OBJECTIVES: Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect underlying disease mechanisms might help in diagnosis, staging and prediction of outcome. We aimed at determining the origin and differential diagnostic and prognostic potential of the putative marker of microglial activation chitotriosidase (CHIT1). METHODS: Altogether 316 patients were included, comprising patients with sporadic ALS, ALS mimics (disease controls (DCo)), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), Parkinson's disease (PD) and healthy controls (Con)...
November 15, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29122933/kinnier-wilson-s-puzzling-features-of-amyotrophic-lateral-sclerosis
#10
Martin R Turner, Andrew Eisen, Matthew C Kiernan, John Ravits, Michael Swash
No abstract text is available yet for this article.
November 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29101254/imaging-the-pathoanatomy-of-amyotrophic-lateral-sclerosis-in-vivo-targeting-a-propagation-based-biological-marker
#11
Jan Kassubek, Hans-Peter Müller, Kelly Del Tredici, Dorothée Lulé, Martin Gorges, Heiko Braak, Albert C Ludolph
OBJECTIVE: Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a dissemination in a regional sequence in four anatomically defined patterns. The aim of this retrospective study was to see whether longitudinal diffusion tensor imaging (DTI) data support the pathological findings. METHODS: The application of DTI analysis to fibre structures that are prone to be involved at each neuropathological pattern of ALS was performed in a monocentre sample of 67 patients with ALS and 31 controls that obtained at least one follow-up scan after a median of 6 months...
November 3, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29101253/superficial-white-matter-damage-in-anti-nmda-receptor-encephalitis
#12
Owen Robert Phillips, Shantanu H Joshi, Katherine L Narr, David W Shattuck, Manpreet Singh, Margherita Di Paola, Christoph J Ploner, Harald Prüss, Paul Friedemann, Carsten Finke
BACKGROUND: Clinical brain MRI is normal in the majority of patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. However, extensive deep white matter damage wasrecently identifiedin these patients using diffusion weighted imaging. Here, our aim was to study a particularly vulnerable brain compartment, the late myelinating superficial white matter. METHODS: Forty-six patients with anti-NMDAR encephalitis were included. Ten out of these were considered neurologically recovered (modified Rankin scale of zero), while 36 patients were non-recovered...
November 3, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29089398/establishing-diagnostic-criteria-for-perry-syndrome
#13
Takayasu Mishima, Shinsuke Fujioka, Hiroyuki Tomiyama, Ichiro Yabe, Ryoichi Kurisaki, Naoki Fujii, Ryuji Neshige, Owen A Ross, Matthew J Farrer, Dennis W Dickson, Zbigniew K Wszolek, Nobutaka Hattori, Yoshio Tsuboi
OBJECTIVE: To establish international diagnostic criteria for Perry syndrome, a disorder characterised by clinical signs of parkinsonism, depression/apathy, weight loss, respiratory symptoms, mutations in the DCTN1 gene and TAR DNA-binding protein 43 (TDP-43) pathology. METHODS: Data from the published literature and newly identified patients were gathered and analysed during and after the International Symposium on Perry syndrome in Tokyo to identify diagnostic criteria for Perry syndrome...
October 31, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29089397/imaging-muscle-as-a-potential-biomarker-of-denervation-in-motor-neuron-disease
#14
Thomas M Jenkins, James J P Alix, Charlotte David, Eilish Pearson, D Ganesh Rao, Nigel Hoggard, Eoghan O'Brien, Kathleen Baster, Michael Bradburn, Julia Bigley, Christopher J McDermott, Iain D Wilkinson, Pamela J Shaw
OBJECTIVE: To assess clinical, electrophysiological and whole-body muscle MRI measurements of progression in patients with motor neuron disease (MND), as tools for future clinical trials, and to probe pathophysiological mechanisms in vivo. METHODS: A prospective, longitudinal, observational, clinicoelectrophysiological and radiological cohort study was performed. Twenty-nine patients with MND and 22 age-matched and gender-matched healthy controls were assessed with clinical measures, electrophysiological motor unit number index (MUNIX) and T2-weighted whole-body muscle MRI, at first clinical presentation and 4 months later...
October 31, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29089396/pathogenesis-of-dystonia-is-it-of-cerebellar-or-basal-ganglia-origin
#15
REVIEW
Ryuji Kaji, Kailash Bhatia, Ann M Graybiel
Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch as the basis. Dystonia was originally classified as a basal ganglia disease. It is now regarded as a 'network' disorder including the cerebellum, but the exact pathogenesis being unknown. Rare autopsy studies have found pathology both in the striatum and the cerebellum, and functional disorganisation was reported in the somatosensory cortex in patients...
October 31, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29084870/curative-and-palliative-mri-guided-laser-ablation-for-drug-resistant-epilepsy
#16
REVIEW
Mesha-Gay Brown, Cornelia Drees, Lidia M Nagae, John A Thompson, Steven Ojemann, Aviva Abosch
Epilepsy is a common neurological disorder occurring in 3% of the US adult population. It is characterised by seizures resulting from aberrant hypersynchronous neural activity. Approximately one-third of newly diagnosed epilepsy cases fail to become seizure-free in response to antiseizure drugs. Optimal seizure control, in cases of drug-resistant epilepsy, often requires neurosurgical intervention targeting seizure foci, such as the temporal lobe. Advances in minimally invasive ablative surgical approaches have led to the development of MRI-guided laser interstitial thermal therapy (LITT)...
October 30, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29084869/early-intravenous-immunoglobulin-treatment-in-paraneoplastic-neurological-syndromes-with-onconeural-antibodies
#17
LETTER
Giulia Berzero, Evgenia Karantoni, Caroline Dehais, François Ducray, Laure Thomas, Géraldine Picard, Véronique Rogemond, Gaëlle Candelier, Jean-Philippe Camdessanché, Jean-Christophe Antoine, Jérôme De Seze, Amélie Liou-Schischmanoff, Jérôme Honnorat, Jean-Yves Delattre, Dimitri Psimaras
No abstract text is available yet for this article.
October 30, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29084868/monitoring-disease-progression-with-plasma-creatinine-in-amyotrophic-lateral-sclerosis-clinical-trials
#18
Ruben P A van Eijk, Marinus J C Eijkemans, Toby A Ferguson, Stavros Nikolakopoulos, Jan H Veldink, Leonard H van den Berg
OBJECTIVES: Plasma creatinine is a predictor of survival in amyotrophic lateral sclerosis (ALS). It remains, however, to be established whether it can monitor disease progression and serve as surrogate endpoint in clinical trials. METHODS: We used clinical trial data from three cohorts of clinical trial participants in the LITRA, EMPOWER and PROACT studies. Longitudinal associations between functional decline, muscle strength and survival with plasma creatinine were assessed...
October 30, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29079677/can-we-predict-development-of-impulsive-compulsive-behaviours-in-parkinson-s-disease
#19
Lucia Ricciardi, Christian Lambert, Rosa De Micco, Francesca Morgante, Mark Edwards
OBJECTIVE: To determine clinical and structural imaging predictors of impulsive-compulsive behaviour (ICB) in de novo Parkinson's disease (PD). METHODS: From a cohort of 1116 subjects from the Parkinson's Progression Marker Initiative database, we created a subcohort of 42 de novo PD without ICB at baseline with available 3T MRI and who developed ICB during follow-up. PD-ICB were matched for age, gender and disease duration to 42 patients with PD without ICB over follow-up (PD-no-ICB) and 42 healthy controls (HCs)...
October 27, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29070648/external-ventricular-drain-related-infections-dilemmas-of-definitions-generalisability-and-associations-versus-causations
#20
EDITORIAL
Issam A Awad
No abstract text is available yet for this article.
October 25, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
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