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Journal of Neurology, Neurosurgery, and Psychiatry

Patrick Oeckl, Patrick Weydt, Petra Steinacker, Sarah Anderl-Straub, Frida Nordin, Alexander E Volk, Janine Diehl-Schmid, Peter M Andersen, Johannes Kornhuber, Adrian Danek, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Martin Lauer, Kathrin Müller, Antje Knehr, Johannes Prudlo, Anja Schneider, Dietmar R Thal, Deniz Yilmazer-Hanke, Jochen H Weishaupt, Albert C Ludolph, Markus Otto
OBJECTIVE: To investigate the role of neuroinflammation in asymptomatic and symptomatic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers. METHODS: The neuroinflammatory markers chitotriosidase 1 (CHIT1), YKL-40 and glial fibrillary acidic protein (GFAP) were measured in cerebrospinal fluid (CSF) and blood samples from asymptomatic and symptomatic ALS/FTD mutation carriers, sporadic cases and controls by ELISA. RESULTS: CSF levels of CHIT1, YKL-40 and GFAP were unaffected in asymptomatic mutation carriers (n=16)...
September 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Min Xu, David L H Bennett, Luis Antonio Querol, Long-Jun Wu, Sarosh R Irani, James C Watson, Sean J Pittock, Christopher J Klein
The immune system has long been recognised important in pain regulation through inflammatory cytokine modulation of peripheral nociceptive fibres. Recently, cytokine interactions in brain and spinal cord glia as well as dorsal root ganglia satellite glia have been identified important- in pain modulation. The result of these interactions is central and peripheral sensitisation of nociceptive processing. Additionally, new insights and the term 'autoimmune pain' have emerged through discovery of specific IgGs targeting the extracellular domains of antigens at nodal and synaptic structures, causing pain directly without inflammation by enhancing neuronal excitability...
September 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Steve Vucic
No abstract text is available yet for this article.
September 17, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Georgios Koutsis, Marianthi Breza, Georgios Velonakis, John Tzartos, Dimitrios Kasselimis, Chrisoula Kartanou, Efstratios Karavasilis, Dimitrios Tzanetakos, Maria Anagnostouli, Elisavet Andreadou, Maria-Eleftheria Evangelopoulos, Constantinos Kilidireas, Constantin Potagas, Marios Panas, Georgia Karadima
OBJECTIVE: X linked Charcot-Marie-Tooth disease (CMTX) is a hereditary neuropathy caused by mutations in GJB1 coding for connexin-32, a gap junction protein expressed in Schwann cells, but also found in oligodendrocytes. Four patients with CMTX developing central nervous system (CNS) demyelination compatible with multiple sclerosis (MS) have been individually published. We presently sought to systematically investigate the relationship between CMTX and MS. METHODS: Over 20 years, 70 consecutive patients (36 men) with GJB1 mutations were identified at our Neurogenetics Unit, Athens, Greece, and assessed for clinical features suggestive of MS...
September 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Pamela A McCombe, Shyuan T Ngo, Christine Cong Guo, Amir Fazlollahi, Saskia Bollmann, Liting Wang, Xintao Hu, Markus Barth, Olivier Salvado, Mark Davis, Amelia Ceslis, Gail Robinson, Robert D Henderson, Frederik J Steyn
No abstract text is available yet for this article.
September 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Emma Clare Tallantyre, Paula C Major, Michael J Atherton, W Adam Davies, Fady Joseph, Valentina Tomassini, Trevor P Pickersgill, Katharine Elizabeth Harding, Mark Douglas Willis, Mia Winter, Neil P Robertson
OBJECTIVES: The prevalence and definition of benign multiple sclerosis (BMS) remain controversial. Most definitions are based on the Expanded Disability Status Scale (EDSS), not encompassing the wider impact of disease. The explanation for favourable outcomes remains unclear. We aim to provide a detailed characterisation of patients with low EDSS scores at long disease durations. METHODS: We screened a population-based registry containing 3062 people with MS to identify individuals with unlimited walking ability at disease durations >15 years...
September 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Cecilia Marelli, Ettore Salsano, Letterio S Politi, Pierre Labauge
In adulthood, spinal cord MRI abnormalities such as T2-weighted hyperintensities and atrophy are commonly associated with a large variety of causes (inflammation, infections, neoplasms, vascular and spondylotic diseases). Occasionally, they can be due to rare metabolic or genetic diseases, in which the spinal cord involvement can be a prominent or even predominant feature, or a secondary one. This review focuses on these rare diseases and associated spinal cord abnormalities, which can provide important but over-ridden clues for the diagnosis...
August 27, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Oliver Jonathan Ziff, Gargi Banerjee, Gareth Ambler, David J Werring
OBJECTIVE: Whether statins increase the risk of intracerebral haemorrhage (ICH) in patients with a previous stroke remains uncertain. This study addresses the evidence of statin therapy on ICH and other clinical outcomes in patients with previous ischaemic stroke (IS) or ICH. METHODS: A systematic literature review and meta-analysis was performed in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to assess observational and randomised studies comparing statin therapy with control (placebo or no treatment) in patients with a previous ICH or IS...
August 27, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Rebekah Ahmed
No abstract text is available yet for this article.
August 20, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Martijn T Wijburg, Clemens Warnke, Frederik Barkhof, Bernard M J Uitdehaag, Joep Killestein, Mike P Wattjes
OBJECTIVE: To test the current progressive multifocal leukoencephalopathy (PML) diagnostic criteria by applying them to patients previously diagnosed with natalizumab (NTZ)-associated PML in a real-world clinical setting. METHODS: Patients from the Dutch-Belgian NTZ-PML cohort (n=28) were reviewed at the time of first diagnostic work-up and during follow-up, using the PML diagnostic criteria as proposed in a consensus statement from the American Academy of Neurology...
August 12, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Piergiorgio d'Orio, Michele Rizzi, Valeria Mariani, Veronica Pelliccia, Giorgio Lo Russo, Francesco Cardinale, Michele Nichelatti, Lino Nobili, Massimo Cossu
OBJECT: To compare the occurrence of surgery-related complications in patients with childhood-onset focal epilepsy operated on in the paediatric or in the adult age. To investigate risk factors for surgery-related complications in the whole cohort, with special attention to age at surgery and severe morbidity. METHODS: A cohort of 1282 patients operated on for childhood-onset focal epilepsy was retrospectively analysed. Occurrence of surgery-related complications, including a severely complicated course (SCC: surgical complication requiring reoperation and/or permanent neurological deficit and/or death), was compared between patients operated on in the paediatric age (<16 year-old; 452 cases) and, respectively, in adulthood (≥16 year-old; 830 cases)...
August 12, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Giulio Rognini, Francesco Maria Petrini, Stanisa Raspopovic, Giacomo Valle, Giuseppe Granata, Ivo Strauss, Marco Solcà, Javier Bello-Ruiz, Bruno Herbelin, Robin Mange, Edoardo D'Anna, Riccardo Di Iorio, Giovanni Di Pino, David Andreu, David Guiraud, Thomas Stieglitz, Paolo Maria Rossini, Andrea Serino, Silvestro Micera, Olaf Blanke
No abstract text is available yet for this article.
August 12, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Laura Fuglsang Bech, Christoffer Polcwiartek, Kristian Kragholm, Mikkel Porsborg Andersen, Christopher Rohde, Christian Torp-Pedersen, Jimmi Nielsen, Søren Hagstrøm
OBJECTIVES: In utero exposure to antiepileptic drugs has previously been associated with adverse outcome among offspring, but evidence on longer term milestone development remains limited. We investigated the association between in utero exposure to antiepileptic drugs and learning disabilities in the first year of compulsory education among offspring and assessed which antiepileptic drugs carried the highest risk. METHODS: This population-based case-cohort study used Danish nationwide register data from 2005 to 2008...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Hideyuki Sawada, Tomoko Oeda, Masayuki Kohsaka, Atsushi Umemura, Satoshi Tomita, Kwiyoung Park, Kouichi Mizoguchi, Hidenori Matsuo, Kazuko Hasegawa, Harutoshi Fujimura, Hiroshi Sugiyama, Michikazu Nakamura, Seishi Kikuchi, Kenji Yamamoto, Toshiaki Fukuda, Suminobu Ito, Masashi Goto, Kosuke Kiyohara, Takashi Kawamura
OBJECTIVES: Brain acetylcholine is decreased even in patients with cognitively preserved Parkinson's disease (PD). We investigated whether early and long-term use of donepezil prevents psychosis in non-demented PD patients. METHODS: A double-blinded, placebo-controlled trial was conducted. A total of 145 non-demented PD patients were randomly assigned to receive 5 mg/day donepezil (n=72) or placebo (n=73) for 96 weeks. Medications for PD were not restricted, but antipsychotic drugs were not permitted throughout the study...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Fabrizio D'Ovidio, James P K Rooney, Anne E Visser, Umberto Manera, Ettore Beghi, Giancarlo Logroscino, Roel C H Vermeulen, Jan Herman Veldink, Leonard H van den Berg, Orla Hardiman, Adriano Chiò
OBJECTIVES: Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case-control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS. METHODS: Euro-MOTOR is a case-control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Nirosen Vijiaratnam, Andrew John Lees, Huw R Morris
No abstract text is available yet for this article.
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Bálint S de Vries, Laura M M Rustemeijer, Leonhard A Bakker, Carin D Schröder, Jan H Veldink, Leonard H van den Berg, Tanja C W Nijboer, Michael A van Es
OBJECTIVES: Cognitive and behavioural changes within the spectrum of frontotemporal dementia (FTD) are observed frequently in patients with amyotrophic lateral sclerosis (ALS). Whether these changes also occur in other forms of motor neuron disease (MND) is not well studied. We therefore systemically screened a large cohort of patients with primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) for cognitive and behavioural changes, and subsequently compared our findings with a cohort of patients with ALS...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Katherine C Hughes, Xiang Gao, Jessica M Baker, Christopher Stephen, Iris Y Kim, Linda Valeri, Michael A Schwarzschild, Alberto Ascherio
BACKGROUND: Several non-motor features may individually contribute to identify prodromal Parkinson's disease (PD), but little is known on how they interact. METHODS: We conducted a case-control study nested within the Health Professionals Follow-up Study in a large cohort of men age 40-75 at recruitment in 1986. Cases (n=120) had confirmed PD, were <85 in January 2012, returned a 2012 questionnaire with questions on probable rapid eye movement sleep behaviour disorder (RBD) and constipation sent to all cohort participants and completed in 2014 the Brief Smell Identification Test and a questionnaire assessing parkinsonism and other non-motor PD features (including depressive symptoms, excessive daytime sleepiness, impaired colour vision and body pain)...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Jie Zhang, Liang Tian, Li Zhang, Ruidong Cheng, Ruili Wei, Fangping He, Juebao Li, Benyan Luo, Xiangming Ye
OBJECTIVE: To investigate relationships between cognitive domains and white matter changes in different regions in patients with cognitive deficits after traumatic brain injury (TBI). METHODS: Databases including PubMed, Embase, Web of Science and CENTRAL were searched for studies published before 5 August 2017. Correlation coefficients between cognition and white matter integrity, measured by diffusion metrics, including fractional anisotropy (FA), were pooled from 49 studies including 1405 patients...
August 2, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Audun Osland Vik-Mo, János Bencze, Clive Ballard, Tibor Hortobágyi, Dag Aarsland
No abstract text is available yet for this article.
July 27, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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