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Journal of Neurology, Neurosurgery, and Psychiatry

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https://www.readbyqxmd.com/read/28739605/genetic-variation-in-the-gene-lrp2-increases-relapse-risk-in-multiple-sclerosis
#1
Yuan Zhou, Jennifer S Graves, Steve Simpson, Jac C Charlesworth, Ingrid van der Mei, Emmanuelle Waubant, Lisa F Barcellos, Anita Belman, Lauren Krupp, Robyn Lucas, Anne-Louise Ponsonby, Bruce V Taylor
BACKGROUND: Due to the lack of prospective studies with longitudinal data on relapse, past genetic studies have not attempted to identify genetic factors that predict relapse risk (the primary endpoint of many pivotal clinical trials testing the efficacy of multiple sclerosis (MS) disease-modifying drugs) at a genome-wide scale. METHODS: We conducted a genome-wide association analysis (GWAS) to identify genetic variants that predict MS relapse risk, using a three-stage approach...
July 24, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28724721/hypothalamic-atrophy-is-related-to-body-mass-index-and-age-at-onset-in-amyotrophic-lateral-sclerosis
#2
EDITORIAL
Rebekah Ahmed, I Sadaf Farooqi
No abstract text is available yet for this article.
July 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28724720/diagnosis-of-multiple-sclerosis-a-multicentre-study-to-compare-revised-mcdonald-2010-and-filippi-2010-criteria
#3
LETTER
Paolo Preziosa, Maria A Rocca, Sarlota Mesaros, Alessandro Meani, Xavier Montalban, Jelena Drulovic, Amgad Droby, Frauke Zipp, Massimiliano Calabrese, Jaume Sastre-Garriga, Irena Dujmovic-Basuroski, Alex Rovira, Massimo Filippi
No abstract text is available yet for this article.
July 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28724719/opioid-k-receptor-variant-is-associated-with-a-delayed-onset-of-dyskinesias-in-parkinson-s-disease
#4
LETTER
Roberto Cilia, Rosanna Asselta, Emanuele Cereda, Roberta Benfante, Giuseppina Barbella, Davide Vallauri, Laura Marabini, Diego Fornasari, Stefano Goldwurm, Gianni Pezzoli
No abstract text is available yet for this article.
July 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28716783/adverse-pregnancy-outcomes-in-women-exposed-to-gabapentin-and-pregabalin-data-from-a-population-based-study
#5
LETTER
Barbara Mostacci, Elisabetta Poluzzi, Roberto D'Alessandro, Guido Cocchi, Paolo Tinuper
No abstract text is available yet for this article.
July 17, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28716782/the-reticular-activating-system-in-the-wake-of-temporal-lobe-epilepsy-dazed-and-confused
#6
EDITORIAL
John D Rolston
No abstract text is available yet for this article.
July 17, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28710326/cortical-influences-drive-amyotrophic-lateral-sclerosis
#7
REVIEW
Andrew Eisen, Heiko Braak, Kelly Del Tredici, Roger Lemon, Albert C Ludolph, Matthew C Kiernan
The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates with progressive evolution of a direct corticomotoneuronal system that is unique to primates and markedly enhanced in humans. The failure of this system in ALS may translate into the split hand presentation, gait disturbance, split leg syndrome and bulbar symptomatology related to vocalisation and breathing, and possibly diffuse fasciculation, characteristic of ALS...
July 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28710325/lack-of-t1-hyperintensity-in-the-dentate-nucleus-after-15-administrations-of-a-macrocyclic-contrast-agent-in-multiple-sclerosis
#8
LETTER
Philipp Eisele, Kristina Szabo, Angelika Alonso, Melissa Ong, Michael Platten, Stefan O Schoenberg, Achim Gass
No abstract text is available yet for this article.
July 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28710324/brain-white-matter-fibre-tracts-a-review-of-functional-neuro-oncological-relevance
#9
REVIEW
Natalie L Voets, Andreas Bartsch, Puneet Plaha
State-of-the-art glioma treatment aims to maximise neuro-oncological benefit while minimising losses in quality of life. Optimising this balance remains hindered by our still limited understanding of information processing in the human brain. To help understand individual differences in functional outcomes following neuro-oncological treatment, we review mounting evidence demonstrating the fundamental role that white matter connections play in complex human behaviour. We focus on selected fibre tracts whose destruction is recognised to elicit predictable behavioural deficits and consider specific indications for non-invasive diffusion MRI tractography, the only existing method to map these fibre tracts in vivo, in the selection and planning of neuro-oncological treatments...
July 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28710323/organisation-of-services-and-clinical-practice-in-acute-cerebral-venous-sinus-thrombosis-a-uk-survey
#10
LETTER
Timothy Lavin, Mark Holland, Martin Punter
No abstract text is available yet for this article.
July 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28705900/subtypes-of-primary-angiitis-of-the-cns-identified-by-mri-patterns-reflect-the-size-of-affected-vessels
#11
Simon Schuster, Henrike Bachmann, Vivien Thom, Ann-Katrin Kaufmann-Buehler, Jakob Matschke, Susanne Siemonsen, Markus Glatzel, Jens Fiehler, Christian Gerloff, Tim Magnus, Götz Thomalla
OBJECTIVE: To describe patterns of diagnostic findings, and identify subgroups of primary angiitis of the central nervous system (PACNS). METHODS: We retrospectively analysed 31 patients with PACNS. Cases were selected by predetermined diagnostic criteria and stratified into biopsy-proven and imaging-based PACNS. We compared clinical characteristics, cerebrospinal fluid (CSF) findings and imaging results including high-resolution vessel wall MRI between groups. RESULTS: There were 31 cases of PACNS (mean age 45...
July 13, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28684534/comparing-surgical-approaches-to-lumbar-disc-herniations
#12
EDITORIAL
Jean-Valery C Coumans
No abstract text is available yet for this article.
July 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28684533/is-mog-igg-another-biomarker-for-neuromyelitis-optica
#13
EDITORIAL
Ichiro Nakashima
No abstract text is available yet for this article.
July 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28684532/longitudinal-analysis-of-myelin-oligodendrocyte-glycoprotein-antibodies-in-cns-inflammatory-diseases
#14
Jae-Won Hyun, Mark R Woodhall, Su-Hyun Kim, In Hye Jeong, Byungsoo Kong, Gayoung Kim, Yeseul Kim, Min Su Park, Sarosh R Irani, Patrick Waters, Ho Jin Kim
BACKGROUND: We evaluated the seroprevalence of myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG) and associated clinical features of patients from a large adult-dominant unselected cohort with mainly relapsing central nervous system (CNS) inflammatory diseases. We also investigate the clinical relevance of MOG-IgG through a longitudinal analysis of serological status over a 2-year follow-up period. METHODS: Serum samples from 505 patients with CNS inflammatory diseases at the National Cancer Center were analysed using cell-based assays for MOG-IgG and aquaporin-4 immunoglobulin G (AQP4-IgG)...
July 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28668776/gnao1-related-movement-disorder-with-life-threatening-exacerbations-movement-phenomenology-and-response-to-dbs
#15
LETTER
Michaela Waak, Shekeeb S Mohammad, David Coman, Kate Sinclair, Lisa Copeland, Peter Silburn, Terry Coyne, Jim McGill, Mary O'Regan, Richard Selway, Joseph Symonds, Padraic Grattan-Smith, Jean-Pierre Lin, Russell C Dale, Stephen Malone
No abstract text is available yet for this article.
July 1, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28668775/towards-an-early-clinical-diagnosis-of-sporadic-cjd-vv2-ataxic-type
#16
Simone Baiardi, Anna Magherini, Sabina Capellari, Veronica Redaelli, Anna Ladogana, Marcello Rossi, Fabrizio Tagliavini, Maurizio Pocchiari, Giorgio Giaccone, Piero Parchi
INTRODUCTION: Sporadic Creutzfeldt-Jakob disease (sCJD) includes a broad spectrum of clinical-pathological subtypes, which complicates the clinical differential diagnosis with other rapidly progressive neurological syndromes. AIM: To provide a better characterisation of clinical features and results of diagnostic investigations, especially at an early disease stage, in patients with sCJDVV2, the second most common sCJD subtype. METHODS: We evaluated neurological symptoms/signs, and results of brain diffusion-weighted resonance imaging (DW-MRI), electroencephalographic recordings (EEG) and cerebrospinal fluid (CSF) biomarker studies in 120 patients with a definite (n=93) or probable (n=27) diagnosis of sCJDVV2...
July 1, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28659393/interaction-between-apoe-%C3%A9-4-and-hmgb1-is-associated-with-widespread-cortical-thinning-in-mild-cognitive-impairment
#17
LETTER
Heidi Foo, Kok Pin Ng, Jayne Tan, Lina Lim, Russell Jude Chander, Ting Ting Yong, Nagaendran Kandiah
No abstract text is available yet for this article.
June 28, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28642287/genetic-screening-in-sporadic-als-and-ftd
#18
EDITORIAL
Martin R Turner, Ammar Al-Chalabi, Adriano Chio, Orla Hardiman, Matthew C Kiernan, Jonathan D Rohrer, James Rowe, William Seeley, Kevin Talbot
The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least 10% of those diagnosed with ALS or FTD are known to carry an autosomal dominant genetic mutation. There is no consensus on what constitutes a positive family history, and ascertainment is unreliable for many reasons. However, symptomatic individuals often wish to understand as much as possible about the cause of their disease, and to share this knowledge with their family...
June 22, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28642286/brain-regions-important-for-recovery-after-severe-post-stroke-upper-limb-paresis
#19
Jane M Rondina, Chang-Hyun Park, Nick S Ward
Background The ability to predict outcome after stroke is clinically important for planning treatment and for stratification in restorative clinical trials. In relation to the upper limbs, the main predictor of outcome is initial severity, with patients who present with mild to moderate impairment regaining about 70% of their initial impairment by 3 months post-stroke. However, in those with severe presentations, this proportional recovery applies in only about half, with the other half experiencing poor recovery...
June 22, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28630377/effects-of-cognitive-reserve-depend-on-executive-and-semantic-demands-of-the-task
#20
R Ryan Darby, Michael Brickhouse, David A Wolk, Bradford C Dickerson
BACKGROUND: Cognitive reserve (CR) is one factor that helps to maintain cognitive function in patients with Alzheimer's disease (AD). Whether the effects of CR depend on the semantic/executive components of the task remains unknown. METHODS: 470 patients (138 with AD, 332 with mild cognitive impairment (MCI)) were selected from the Alzheimer's Disease Neuroimaging Initiative database. Linear regression models were used to determine the effects of CR (years of education) on cognitive performance after controlling for demographic factors and regional cortical atrophy...
June 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
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