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Journal of Neurology, Neurosurgery, and Psychiatry

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https://www.readbyqxmd.com/read/28214798/intensive-blood-pressure-lowering-in-patients-with-acute-intracerebral-haemorrhage-clinical-outcomes-and-haemorrhage-expansion-systematic-review-and-meta-analysis-of-randomised-trials
#1
Gregoire Boulouis, Andrea Morotti, Joshua N Goldstein, Andreas Charidimou
INTRODUCTION: It is unclear whether intensive lowering of blood pressure (BP) at the acute phase of intracerebral haemorrhage (ICH) is beneficial. We performed a meta-analysis of randomised controlled trials (RCTs) to assess whether intensive BP lowering in patients with acute ICH is safe and effective in improving clinical outcomes. METHODS: We searched PubMed, EMBASE and the Cochrane databases for relevant RCTs and calculated pooled OR for 3-month mortality (safety outcome) and 3-month death or dependency (modified Rankin Scale (mRs) ≥3;efficacy outcome), in patients with acute ICH randomised to either intensive BP-lowering or standard BP-lowering treatment protocols...
February 18, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28214797/peduncolopontine-nucleus-stimulation-in-progressive-supranuclear-palsy-a-randomised-trial
#2
LETTER
Emma Scelzo, Andres M Lozano, Clement Hamani, Yu-Yan Poon, Amaal Aldakheel, Cindy Zadikoff, Anthony E Lang, Elena Moro
No abstract text is available yet for this article.
February 18, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28209652/progressive-spinal-cord-atrophy-in-manifest-and-premanifest-huntington-s-disease
#3
LETTER
Weike Wilhelms, Barbara Bellenberg, Odo Köster, Florian Weiler, Rainer Hoffmann, Ralf Gold, Carsten Saft, Carsten Lukas
No abstract text is available yet for this article.
February 16, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28209651/bilateral-frontal-cortex-encephalitis-and-paraparesis-in-a-patient-with-anti-mog-antibodies
#4
LETTER
Juichi Fujimori, Yoshiki Takai, Ichiro Nakashima, Douglas Kazutoshi Sato, Toshiyuki Takahashi, Kimihiko Kaneko, Shuhei Nishiyama, Mika Watanabe, Hiroaki Tanji, Michiko Kobayashi, Tatsuro Misu, Masashi Aoki, Kazuo Fujihara
No abstract text is available yet for this article.
February 16, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28209650/als-genetic-epidemiology-how-simplex-is-the-genetic-epidemiology-of-als
#5
EDITORIAL
Jan H Veldink
No abstract text is available yet for this article.
February 16, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28188196/diagnostic-challenges-in-hereditary-transthyretin-amyloidosis-with-polyneuropathy-avoiding-misdiagnosis-of-a-treatable-hereditary-neuropathy
#6
LETTER
Andrea Cortese, Elisa Vegezzi, Alessandro Lozza, Enrico Alfonsi, Alessandra Montini, Arrigo Moglia, Giampaolo Merlini, Laura Obici
No abstract text is available yet for this article.
February 10, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28115470/intracellular-and-non-neuronal-targets-of-voltage-gated-potassium-channel-complex-antibodies
#7
Bethan Lang, Mateusz Makuch, Teresa Moloney, Inga Dettmann, Swantje Mindorf, Christian Probst, Winfried Stoecker, Camilla Buckley, Charles R Newton, M Isabel Leite, Paul Maddison, Lars Komorowski, Jane Adcock, Angela Vincent, Patrick Waters, Sarosh R Irani
OBJECTIVES: Autoantibodies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with limbic encephalitis, faciobrachial dystonic seizures, Morvan's syndrome and neuromyotonia. However, in routine testing, VGKC complex antibodies without LGI1 or CASPR2 reactivities (double-negative) are more common than LGI1 or CASPR2 specificities. Therefore, the target(s) and clinical associations of double-negative antibodies need to be determined...
January 23, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28108522/association-of-motor-milestones-smn2-copy-and-outcome-in-spinal-muscular-atrophy-types-0-4
#8
LETTER
Renske I Wadman, Marloes Stam, Marleen Gijzen, Henny H Lemmink, Irina N Snoeck, Camiel A Wijngaarde, Kees P J Braun, Marja A G C Schoenmakers, Leonard H van den Berg, Dennis Dooijes, W-Ludo van der Pol
No abstract text is available yet for this article.
January 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28108521/nodopathy-chronic-inflammatory-demyelinating-polyneuropathy-with-anti-neurofascin-155-antibodies
#9
EDITORIAL
Satoshi Kuwabara, Sonoko Misawa, Masahiro Mori
No abstract text is available yet for this article.
January 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28104748/movement-retraining-for-the-dysfunctional-brain
#10
EDITORIAL
Jon Stone, Alan Carson
No abstract text is available yet for this article.
January 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28100721/meta-analysis-of-timing-of-endovascular-aneurysm-treatment-in-subarachnoid-haemorrhage-inconsistent-results-of-early-treatment-within-1-day
#11
Sapna Rawal, Paula Alcaide-Leon, R Loch Macdonald, Gabriel J E Rinkel, J Charles Victor, Timo Krings, Moira K Kapral, Andreas Laupacis
BACKGROUND AND PURPOSE: To systematically review and meta-analyse the data on impact of timing of endovascular treatment in aneurysmal subarachnoid haemorrhage (SAH) to determine if earlier treatment is associated with improved clinical outcomes and reduced case fatality. METHODS: We searched MEDLINE, Cochrane database, EMBASE and Web of Science to identify studies for inclusion. The measures of effect utilised were unadjusted/adjusted ORs. Effect estimates were combined using random effects models for each outcome (poor outcome, case fatality); heterogeneity was assessed using the I(2) index...
January 18, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28073817/paranodal-dissection-in-chronic-inflammatory-demyelinating-polyneuropathy-with-antineurofascin-155-and-anticontactin-1-antibodies
#12
Haruki Koike, Masato Kadoya, Ken-Ichi Kaida, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Daisuke Kato, Hidenori Ogata, Ryo Yamasaki, Noriyuki Matsukawa, Jun-Ichi Kira, Masahisa Katsuno, Gen Sobue
OBJECTIVE: To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularly focusing on the fine structures of the paranodes. METHODS: We assessed sural nerve biopsy specimens obtained from 9 patients with CIDP with antineurofascin-155 antibodies and 1 patient with anticontactin-1 antibodies. 13 patients with CIDP without these antibodies were also examined to compare pathological findings...
January 10, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28069879/treating-clinically-isolated-syndrome-the-long-game
#13
EDITORIAL
Jeremy Chataway
No abstract text is available yet for this article.
January 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28057713/genetic-epidemiology-of-amyotrophic-lateral-sclerosis-a-systematic-review-and-meta-analysis
#14
Zhang-Yu Zou, Zhi-Rui Zhou, Chun-Hui Che, Chang-Yun Liu, Rao-Li He, Hua-Pin Huang
BACKGROUND: Genetic studies have shown that C9orf72, SOD1, TARDBP and FUS are the most common mutated genes in amyotrophic lateral sclerosis (ALS). Here, we performed a meta-analysis to determine the mutation frequencies of these major ALS-related genes in patients with ALS. METHODS: We performed an extensive literature research to identify all original articles reporting frequencies of C9orf72, SOD1, TARDBP and FUS mutations in ALS. The mutation frequency and effect size of each study were combined...
January 5, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28039320/modulation-of-cortical-excitability-to-normalise-brain-function-and-improve-cognition-in-multiple-sclerosis
#15
EDITORIAL
Maria A Rocca, Massimo Filippi
No abstract text is available yet for this article.
December 30, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28039319/new-ideas-on-the-als-functional-rating-scale
#16
EDITORIAL
Michael Swash
No abstract text is available yet for this article.
December 30, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28039318/a-quantitative-meta-analysis-of-olfactory-dysfunction-in-mild-cognitive-impairment
#17
David R Roalf, Madelyn J Moberg, Bruce I Turetsky, Laura Brennan, Sushila Kabadi, David A Wolk, Paul J Moberg
BACKGROUND: The connection between Alzheimer's disease (AD) and olfactory deficits is well documented and further, alterations in olfactory functioning may signal declines in functions associated with dementia. The aim of the present comprehensive meta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI). METHODS: Articles were identified through computerised literature search from inception to 30 June 2016 using PubMed, MEDLINE and PsychInfo databases...
December 30, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28039317/subcutaneous-interferon-%C3%AE-1a-in-the-treatment-of-clinically-isolated-syndromes-3-year-and-5-year-results-of-the-phase-iii-dosing-frequency-blind-multicentre-reflexion-study
#18
Giancarlo Comi, Nicola De Stefano, Mark S Freedman, Frederik Barkhof, Bernard M J Uitdehaag, Marlieke de Vos, Kurt Marhardt, Liang Chen, Delphine Issard, Ludwig Kappos
OBJECTIVE: Early treatment following a first clinical demyelinating event (FCDE) delays further disease activity in patients with multiple sclerosis (MS). This study determined the effects of early versus delayed treatment (DT) with subcutaneous interferon (sc IFN) β-1a 44 μg in patients with an FCDE up to 60 months postrandomisation. METHODS: Patients who completed the 24-month double-blind REFLEX (REbif FLEXible dosing in early MS) study entered an extension (REFLEXION, REbif FLEXible dosing in early MS extensION): patients initially randomised to sc IFN β-1a and not reaching clinically definite MS (clinically definite MS, CDMS (second attack or sustained Expanded Disability Status Scale (EDSS) score increase)) continued original treatment (three times weekly (tiw) or once weekly (qw)); placebo patients switched to tiw (DT); patients with CDMS switched to tiw...
December 30, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28039316/newer-epilepsy-surgeries
#19
EDITORIAL
Michael Samuel, Richard Selway
No abstract text is available yet for this article.
December 30, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28003344/differentiating-lower-motor-neuron-syndromes
#20
REVIEW
Nidhi Garg, Susanna B Park, Steve Vucic, Con Yiannikas, Judy Spies, James Howells, William Huynh, José M Matamala, Arun V Krishnan, John D Pollard, David R Cornblath, Mary M Reilly, Matthew C Kiernan
Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve up to the level of the anterior horn cell. A variety of hereditary causes are recognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of familial motor neuron disease. Recent genetic advances have resulted in the identification of a variety of disease-causing mutations. Immune-mediated disorders, including multifocal motor neuropathy and variants of chronic inflammatory demyelinating polyneuropathy, account for a proportion of LMN presentations and are important to recognise, as effective treatments are available...
December 21, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
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