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Journal of Neurology, Neurosurgery, and Psychiatry

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https://www.readbyqxmd.com/read/30636701/ultra-high-dose-methylcobalamin-in-amyotrophic-lateral-sclerosis-a-long-term-phase-ii-iii-randomised-controlled-study
#1
Ryuji Kaji, Takashi Imai, Yasuo Iwasaki, Koichi Okamoto, Masanori Nakagawa, Yasuo Ohashi, Takao Takase, Takahisa Hanada, Hiroki Shimizu, Kunio Tashiro, Shigeki Kuzuhara
OBJECTIVE: To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis (ALS). METHODS: 373 patients with ALS (El Escorial definite or probable; laboratory-supported probable; duration ≤36 months) were randomly assigned to placebo, 25 mg or 50 mg of methylcobalamin groups. The primary endpoints were the time interval to primary events (death or full ventilation support) and changes in the Revised ALS Functional Rating Scale (ALSFRS-R) score from baseline to week 182...
January 13, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30636700/hla-class-ii-allele-drb1-16-02-is-associated-with-anti-nmdar-encephalitis
#2
Yaqing Shu, Wei Qiu, Junfeng Zheng, Xiaobo Sun, Junping Yin, Xiaoli Yang, Xiaoyang Yue, Chen Chen, Zhihui Deng, Shasha Li, Yu Yang, Fuhua Peng, Zhengqi Lu, Xueqiang Hu, Frank Petersen, Xinhua Yu
BACKGROUND AND OBJECTIVE: Aetiology and pathogenesis of anti- N -methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the most common autoimmune encephalitis, is largely unknown. Since an association of the disease with the human leucocyte antigen (HLA) has not been shown so far, we here investigated whether anti-NMDAR encephalitis is associated with the HLA locus. METHODS: HLA loci of 61 patients with anti-NMDAR encephalitis and 571 healthy controls from the Chinese Han population were genotyped and analysed for this study...
January 13, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30636699/comparison-of-fingolimod-dimethyl-fumarate-and-teriflunomide-for-multiple-sclerosis
#3
Tomas Kalincik, Eva Kubala Havrdova, Dana Horakova, Guillermo Izquierdo, Alexandre Prat, Marc Girard, Pierre Duquette, Pierre Grammond, Marco Onofrj, Alessandra Lugaresi, Serkan Ozakbas, Ludwig Kappos, Jens Kuhle, Murat Terzi, Jeannette Lechner-Scott, Cavit Boz, Francois Grand'Maison, Julie Prevost, Patrizia Sola, Diana Ferraro, Franco Granella, Maria Trojano, Roberto Bergamaschi, Eugenio Pucci, Recai Turkoglu, Pamela A McCombe, Vincent Van Pesch, Bart Van Wijmeersch, Claudio Solaro, Cristina Ramo-Tello, Mark Slee, Raed Alroughani, Bassem Yamout, Vahid Shaygannejad, Daniele Spitaleri, José Luis Sánchez-Menoyo, Radek Ampapa, Suzanne Hodgkinson, Rana Karabudak, Ernest Butler, Steve Vucic, Vilija Jokubaitis, Tim Spelman, Helmut Butzkueven
OBJECTIVE: Oral immunotherapies have become a standard treatment in relapsing-remitting multiple sclerosis. Direct comparison of their effect on relapse and disability is needed. METHODS: We identified all patients with relapsing-remitting multiple sclerosis treated with teriflunomide, dimethyl fumarate or fingolimod, with minimum 3-month treatment persistence and disability follow-up in the global MSBase cohort study. Patients were matched using propensity scores...
January 13, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30630960/neurofilaments-and-tau-in-csf-in-an-infant-with-sma-type-1-treated-with-nusinersen
#4
Benedikt Winter, René Guenther, Albert Christian Ludolph, Andreas Hermann, Markus Otto, Claudia Diana Wurster
No abstract text is available yet for this article.
January 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30630959/food-allergies-and-multiple-sclerosis
#5
Mauricio Franco Farez
No abstract text is available yet for this article.
January 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30630958/another-brick-in-the-wall-further-evidence-supporting-the-role-of-haematopoietic-stem-cell-transplantation-in-treating-multiple-sclerosis
#6
Harold L Atkins
No abstract text is available yet for this article.
January 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30630957/early-weight-loss-in-amyotrophic-lateral-sclerosis-outcome-relevance-and-clinical-correlates-in-a-population-based-cohort
#7
Cristina Moglia, Andrea Calvo, Maurizio Grassano, Antonio Canosa, Umberto Manera, Fabrizio D'Ovidio, Alessandro Bombaci, Enrica Bersano, Letizia Mazzini, Gabriele Mora, Adriano Chiò
OBJECTIVES: To assess the role of body mass index (BMI) and of the rate of weight loss as prognostic factors in amyotrophic lateral sclerosis (ALS) and to explore the clinical correlates of weight loss in the early phases of the disease. METHODS: The study cohort included all ALS patients in Piemonte/Valle d'Aosta in the 2007-2011 period. Overall survival and the probability of death/tracheostomy at 18 months (logistic regression model) were calculated. RESULTS: Of the 712 patients, 620 (87...
January 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30630956/effects-of-onabotulinumtoxina-treatment-for-chronic-migraine-on-common-comorbidities-including-depression-and-anxiety
#8
Andrew M Blumenfeld, Stewart J Tepper, Lawrence D Robbins, Aubrey Manack Adams, Dawn C Buse, Amelia Orejudos, Stephen D Silberstein
OBJECTIVE: To assess the effects of onabotulinumtoxinA treatment for chronic migraine (CM) on comorbid symptoms of depression, anxiety, fatigue and poor sleep quality. METHODS: The Chronic Migraine OnabotulinuMtoxinA Prolonged Efficacy open-Label (COMPEL) study is a multicentre, open-label, prospective study assessing the long-term safety and efficacy of onabotulinumtoxinA 155 U over nine treatments (108 weeks) in adults with CM. The Patient Health Questionnaire (PHQ-9) and Generalised Anxiety Disorder (GAD-7) scales were used to assess the effects of onabotulinumtoxinA on comorbid symptoms of depression and anxiety, respectively...
January 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30630955/inflammatory-markers-in-alzheimer-s-disease-and-mild-cognitive-impairment-a-meta-analysis-and-systematic-review-of-170-studies
#9
Xue-Ning Shen, Li-Dong Niu, Yan-Jiang Wang, Xi-Peng Cao, Qiang Liu, Lan Tan, Can Zhang, Jin-Tai Yu
OBJECTIVE: Inflammation plays a crucial role in the pathogenesis of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Our study aimed to analyse previous inconsistent results of inflammatory markers in AD and MCI quantitatively. METHODS: Studies reporting concentrations of peripheral or cerebrospinal fluid (CSF) markers were included, and eligible data on AD, MCI and control were extracted. Pooled Hedges's g was adopted to illustrate comparisons, and various confounding factors were used to explore sources of heterogeneity...
January 10, 2019: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30598430/association-of-autonomic-symptoms-with-disease-progression-and-survival-in-progressive-supranuclear-palsy
#10
Marcos C B Oliveira, Helen Ling, Andrew J Lees, Janice L Holton, Eduardo De Pablo-Fernandez, Thomas T Warner
BACKGROUND: Development of autonomic failure is associated with more rapid disease course and shorter survival in patients with Parkinson's disease and multiple system atrophy. However, autonomic symptoms have not been specifically assessed as a prognostic factor in progressive supranuclear palsy (PSP). We evaluated whether development of autonomic symptoms is associated with disease progression and survival in PSP. METHODS: A retrospective review of clinical data from consecutive patients with autopsy-confirmed PSP from the Queen Square Brain Bank between January 2012 and November 2016 was performed...
December 31, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30567722/platelet-abnormalities-in-huntington-s-disease
#11
Hélèna L Denis, Jérôme Lamontagne-Proulx, Isabelle St-Amour, Sarah L Mason, Jesse W Rowley, Nathalie Cloutier, Marie-Ève Tremblay, Antony T Vincent, Peter V Gould, Sylvain Chouinard, Andrew S Weyrich, Matthew T Rondina, Roger A Barker, Eric Boilard, Francesca Cicchetti
Huntington's disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the production of an abnormal protein, mutant huntingtin (mHtt). This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage...
December 19, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30563943/food-allergies-are-associated-with-increased-disease-activity-in-multiple-sclerosis
#12
Rami Fakih, Camilo Diaz-Cruz, Alicia S Chua, Cindy Gonzalez, Brian C Healy, Neda Sattarnezhad, Bonnie I Glanz, Howard L Weiner, Tanuja Chitnis
OBJECTIVE: The association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity. METHODS: A subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies...
December 18, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30554138/risk-of-intracerebral-haemorrhage-in-chinese-patients-with-atrial-fibrillation-on-warfarin-with-cerebral-microbleeds-the-ipaac-warfarin-study
#13
Yannie Soo, Jill M Abrigo, Kam Tat Leung, Suk Fung Tsang, Hing Lung Ip, Sze Ho Ma, Karen Ma, Wing Chi Fong, Siu Hung Li, Richard Li, Ping Wing Ng, Kwok Kui Wong, Wenyan Liu, Bonnie Y K Lam, Ka Sing Lawrence Wong, Vincent Mok, Winnie Chiu Wing Chu, Thomas W Leung
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs), which predict future intracerebral haemorrhage (ICH), may guide anticoagulant decisions for atrial fibrillation (AF). We aimed to evaluate the risk of warfarin-associated ICH in Chinese patients with AF with CMBs. METHODS: In this prospective, observational, multicentre study, we recruited Chinese patients with AF who were on or intended to start anticoagulation with warfarin from six hospitals in Hong Kong. CMBs were evaluated with 3T MRI brain at baseline...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30554137/disruption-of-periaqueductal-grey-default-mode-network-functional-connectivity-predicts-persistent-post-traumatic-headache-in-mild-traumatic-brain-injury
#14
Xuan Niu, Lijun Bai, Yingxiang Sun, Shan Wang, Jieli Cao, Chuanzhu Sun, Zhuonan Wang, Hui Xu, Shuoqiu Gan, Geng Fan, Wenmin Huang, Chenghui Gu, Bo Yin, Guanghui Bai, Xiaoling Xu, Ming Zhang
OBJECTIVE: Post-traumatic headache (PTH) is one of the most frequent and persistent physical symptoms following mild traumatic brain injury (mTBI) and develop in more than 50% of this population. This study aimed to investigate the periaqueductal grey (PAG)-seeded functional connectivity (FC) in patients with mTBI with acute post-traumatic headache (APTH) and further examine whether the FC can be used as a neural biomarker to identify patients developing chronic pain 3 months postinjury...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30554136/yield-of-peripheral-sodium-channels-gene-screening-in-pure-small-fibre-neuropathy
#15
Ivo Eijkenboom, Maurice Sopacua, Janneke G J Hoeijmakers, Bianca T A de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J M Smeets, Stephen G Waxman, Giuseppe Lauria, Ingemar S J Merkies, Catharina G Faber, Monique M Gerrits
BACKGROUND: Neuropathic pain is common in peripheral neuropathy. Recent genetic studies have linked pathogenic voltage-gated sodium channel (VGSC) variants to human pain disorders. Our aims are to determine the frequency of SCN9A , SCN10A and SCN11A variants in patients with pure small fibre neuropathy (SFN), analyse their clinical features and provide a rationale for genetic screening. METHODS: Between September 2009 and January 2017, 1139 patients diagnosed with pure SFN at our reference centre were screened for SCN9A , SCN10A and SCN11A variants...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30554135/smart-cpt-for-veterans-with-comorbid-post-traumatic-stress-disorder-and-history-of-traumatic-brain-injury-a-randomised-controlled-trial
#16
Amy J Jak, Sarah Jurick, Laura D Crocker, Mark Sanderson-Cimino, Robin Aupperle, Carie S Rodgers, Kelsey R Thomas, Briana Boyd, Sonya B Norman, Ariel J Lang, Amber V Keller, Dawn M Schiehser, Elizabeth W Twamley
OBJECTIVE: To better concurrently address emotional and neuropsychological symptoms common in veterans with comorbid post-traumatic stress disorder (PTSD) and history of traumatic brain injury (TBI), we integrated components of compensatory cognitive training from the Cognitive Symptom Management and Rehabilitation Therapy (CogSMART) programme into cognitive processing therapy (CPT) for PTSD to create a hybrid treatment, SMART-CPT (CogSMART+CPT). This study compared the efficacy of standard CPT with SMART-CPT for treatment of veterans with comorbid PTSD and history of TBI reporting cognitive symptoms...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30554134/functional-cognitive-and-physical-outcomes-3-years-after-minor-lacunar-or-cortical-ischaemic-stroke
#17
Caroline A McHutchison, Vera Cvoro, Stephen Makin, Francesca M Chappell, Kirsten Shuler, Joanna M Wardlaw
OBJECTIVE: Many studies examining stroke outcomes focus on more severe strokes or have short follow-up periods, so the long-term outcomes post-minor ischaemic stroke are unclear. METHODS: We recruited participants from inpatient and outpatient services with a lacunar or minor cortical ischaemic stroke (National Institutes of Health Stroke Scale score <8) and assessed current and premorbid cognitive functioning (Addenbrooke's Cognitive Examination-Revised (ACE-R), National Adult Reading Test (NART)), physical functioning (Timed Get Up and Go (TUG), 9-Hole Peg Test (9HPT)), dependency (modified Rankin Scale (mRS)), depression (Beck's Depression Inventory) in-person and remotely (Stroke Impact Scale)...
December 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30538138/prospective-phase-ii-clinical-trial-of-autologous-haematopoietic-stem-cell-transplant-for-treatment-refractory-multiple-sclerosis
#18
John J Moore, Jennifer C Massey, Carole D Ford, Melissa L Khoo, John J Zaunders, Kevin Hendrawan, Yael Barnett, Michael H Barnett, Kain A Kyle, Robert Zivadinov, Kris C Ma, Sam T Milliken, Ian J Sutton, David D F Ma
BACKGROUND: Autologous haematopoietic stem cell transplantation (AHSCT) has been explored as a therapeutic intervention in multiple sclerosis (MS) over the last two decades; however, prospective clinical trials of the most common myeloablative conditioning regimen, BEAM, are limited. Furthermore, patient selection, optimal chemotherapeutic regimen and immunological changes associated with disease response require ongoing exploration. We present the outcomes, safety and immune reconstitution (IR) of patients with active, treatment refractory MS...
December 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30538137/sexuality-and-intimacy-in-als-systematic-literature-review-and-future-perspectives
#19
Barbara Poletti, Laura Carelli, Federica Solca, Rita Pezzati, Andrea Faini, Nicola Ticozzi, Hiroshi Mitsumoto, Vincenzo Silani
Several features of amyotrophic lateral sclerosis (ALS) impact on sexuality and intimate relationship; however, the issue has received poor attention so far. We performed a systematic literature review in order to provide an up-to-date account of sexuality in ALS. References were identified by searches of PubMed, Web of Science, Scopus and PsycINFO (1970-2017, English literature). The following were the key terms: 'sexual' OR 'sexuality' OR 'intimacy' OR 'marital' AND 'ALS' OR 'Amyotrophic Lateral Sclerosis' OR 'Motor Neuron Disease' OR 'MND'...
December 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30530568/muscle-mri-in-a-large-cohort-of-patients-with-oculopharyngeal-muscular-dystrophy
#20
Alicia Alonso-Jimenez, Rosemarie H M J M Kroon, Aida Alejaldre-Monforte, Claudia Nuñez-Peralta, Corinne G C Horlings, Baziel G M van Engelen, Montse Olivé, Laura González, Enric Verges-Gil, Carmen Paradas, Celedonio Márquez, Matteo Garibaldi, Pía Gallano, Maria José Rodriguez, Lidia Gonzalez-Quereda, Cristina Dominguez Gonzalez, John Vissing, Freja Fornander, Anne-Sofie Vibæk Eisum, Tania García-Sobrino, Julio Pardo, Roberto García-Figueiras, Nuria Muelas, Juan Jesús Vilchez, Solange Kapetanovic, Giorgio Tasca, Mauro Monforte, Enzo Ricci, María Teresa Gomez, Jorge Alfredo Bevilacqua, Jorge Diaz-Jara, Ivonne Ingrid Zamorano, Robert Yves Carlier, Pascal Laforet, Ana Pelayo-Negro, Alba Ramos-Fransi, Amaia Martínez, Chiara Marini-Bettolo, Volker Straub, Gerardo Gutiérrez, María Asunción Martín, Germán Morís, Roberto Fernández-Torrón, Adolfo Lopez De Munaín, Elena Cortes-Vicente, Luis Querol, Ricardo Rojas-García, Isabel Illa, Jordi Diaz-Manera
BACKGROUND AND OBJECTIVE: Oculopharyngeal muscular dystrophy (OPMD) is a genetic disorder caused by an abnormal expansion of GCN triplets within the PABPN1 gene. Previous descriptions have focused on lower limb muscles in small cohorts of patients with OPMD, but larger imaging studies have not been performed. Previous imaging studies have been too small to be able to correlate imaging findings to genetic and clinical data. METHODS: We present cross-sectional, T1-weighted muscle MRI and CT-scan data from 168 patients with genetically confirmed OPMD...
December 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
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