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Journal of Neurology

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https://www.readbyqxmd.com/read/29164312/efficacy-and-safety-of-rotigotine-in-elderly-patients-with-parkinson-s-disease-in-comparison-with-the-non-elderly-a-post-hoc-analysis-of-randomized-double-blind-placebo-controlled-trials
#1
Masahiro Nomoto, Hirotaka Iwaki, Hiroyuki Kondo, Masaya Sakurai
Rotigotine-a non-ergot dopamine agonist-has two advantages; it can stimulate all dopamine receptors (D1-D5) like innate dopamine, and its transdermal administration provides continuous dopaminergic stimulation. The age of the patient impacts the effect and adverse events of anti-parkinsonian treatment. We conducted a post hoc analysis on three randomized, double-blind, placebo-controlled trials performed in Japan to clarify the difference of anti-parkinsonian treatment in elderly and non-elderly patients. Data from two combination therapy trials (with levodopa) in advanced stage Parkinson's disease patients and one monotherapy trial in early stage patients were pooled and grouped by age (non-elderly aged < 70, elderly aged 70 +)...
November 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29164311/macdonald-critchley-1900-1997
#2
Stefano Sandrone, Jan van Gijn
No abstract text is available yet for this article.
November 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29159467/the-use-of-multiparametric-quantitative-magnetic-resonance-imaging-for-evaluating-visually-assigned-lesion-groups-in-patients-with-multiple-sclerosis
#3
Christian Thaler, Tobias D Faizy, Jan Sedlacik, Maxim Bester, Jan-Patrick Stellmann, Christoph Heesen, Jens Fiehler, Susanne Siemonsen
In multiple sclerosis (MS), inflammatory lesions present a broad spectrum of histopathologic processes. For a better discrimination, lesions are visually defined into different lesion groups according to their appearance on conventional magnetic resonance imaging (MRI). The aim of this study was to investigate the properties of different MS lesion groups using multiparametric quantitative MRI. 35 patients diagnosed with relapsing-remitting MS received 3 Tesla MRI including magnetization-prepared 2 rapid acquisition gradient echo, diffusion tensor imaging and magnetization transfer imaging...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29159466/efficacy-and-safety-of-perampanel-in-parkinson-s-disease-a-systematic-review-with-meta-analysis
#4
REVIEW
Simona Lattanzi, Elisabetta Grillo, Francesco Brigo, Mauro Silvestrini
BACKGROUND: L-Dopa represents the mainstay of therapy of Parkinson's disease (PD), but its effectiveness is reduced with continued treatment and disease progression. Accordingly, there remains a need to explore novel treatment strategies to manage the signs and symptoms of the later disease stages. The aim of the study was to evaluate the efficacy and safety of adjunctive perampanel (PER) in patients with PD through a meta-analysis of existing trials. METHODS: Randomized, placebo-controlled, double- or single-blind, add-on studies of PER in patients with PD were identified through a systematic literature search...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29159465/changes-in-disability-in-people-with-multiple-sclerosis-a-10-year-prospective-study
#5
David Conradsson, Charlotte Ytterberg, Lena von Koch, Sverker Johansson
BACKGROUND: Little is known about the long-term course of disability in relation with disease severity in people with multiple sclerosis (PwMS). OBJECTIVE: To explore changes in a broad spectrum of disability over 10 years in relation with disease severity in PwMS. METHODS: We conducted a longitudinal study of 155 PwMS who attended the MS Centre at Karolinska University Hospital, Stockholm. Disease severity was determined by the use of the Expanded Disability Status Scale (EDSS) and classified as mild MS (EDSS score 0-3...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29159464/anti-mag-associated-cerebellar-ataxia-and-response-to-rituximab
#6
Panagiotis Zis, Dasappaiah Ganesh Rao, Nigel Hoggard, Ptolemaios Georgios Sarrigiannis, Marios Hadjivassiliou
BACKGROUND: Myelin-associated glycoprotein (MAG) is a glycoprotein specific to Schwann cells. Schwann cells produce myelin for nerve cells in the peripheral nervous system. MAG also plays a role in the central nervous system (CNS) by maintaining myelin integrity and inhibiting axonal regeneration from cerebellar neurons. There is a well-established link between distal demyelinating neuropathy and anti-MAG antibodies in patients with monoclonal gammopathy of unknown significance. We describe a series of five patients with anti-MAG antibodies with evidence of cerebellar rather than just sensory ataxia and our experience of treatment with rituximab...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29159463/a-nationwide-survey-of-the-influence-of-month-of-birth-on-the-risk-of-developing-multiple-sclerosis-in-sweden-and-iceland
#7
Olöf Eliasdottir, Anders Hildeman, Marco Longfils, O Nerman, J Lycke
Previous studies have shown that the risk of multiple sclerosis (MS) is associated with season of birth with a higher proportion of MS patients being born in spring. However, this relationship has recently been questioned and may be due to confounding factors. Our aim was to assess the influence from season or month of birth on the risk of developing MS in Sweden and Iceland. Information about month of birth, gender, and phenotype of MS for patients born 1940-1996 was retrieved from the Swedish MS registry (SMSR), and their place of birth was retrieved from the Swedish Total Population Registry (TPR)...
November 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143210/jean-alexandre-barr%C3%A3-1880-1967
#8
Michał K Owecki, Piotr Skalski, Anita Magowska
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143209/the-medial-vestibular-nuclei-a-vulnerable-target-in-thiamine-deficiency
#9
Jorge C Kattah, Cindy Guede, Bahareh Hassanzadeh
BACKGROUND: Bilateral medial vestibular nuclei (MVN) is a common target in thiamine depletion and results in acute vestibular failure. Involvement of the MVN was present in 27 out of 38 brainstem sections reported in the largest thiamine deficiency autopsy cohort with Wernicke's encephalopathy. METHOD: Serial clinical, imaging and vestibulo-ocular reflex gain measured with the video head impulse (vHIT) in one patient with acute thiamine deficiency. RESULTS: Low horizontal VOR gain correlated with an abnormal manual head impulse and with MRI evidence of MVN in an alcohol-dependent patient with low thiamine levels...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143208/a-new-measure-for-end-of-life-planning-preparation-and-preferences-in-huntington-disease-hdqlife-end-of-life-planning
#10
Noelle E Carlozzi, E A Hahn, S A Frank, J S Perlmutter, N D Downing, M K McCormack, S Barton, M A Nance, S G Schilling
BACKGROUND: Huntington disease is a fatal inherited neurodegenerative disease. Because the end result of Huntington disease is death due to Huntington disease-related causes, there is a need for better understanding and caring for individuals at their end of life. AIM: The purpose of this study was to develop a new measure to evaluate end of life planning. DESIGN: We conducted qualitative focus groups, solicited expert input, and completed a literature review to develop a 16-item measure to evaluate important aspects of end of life planning for Huntington disease...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143207/contribution-of-eeg-in-transient-neurological-deficits
#11
Pierre Lozeron, Nadine Carole Tcheumeni, Sahar Turki, Hélène Amiel, Elodie Meppiel, Sana Masmoudi, Caroline Roos, Isabelle Crassard, Patrick Plaisance, Houria Benbetka, Jean-Pierre Guichard, Emmanuel Houdart, Hélène Baudoin, Nathalie Kubis
Identification of stroke mimics and 'chameleons' among transient neurological deficits (TND) is critical. Diagnostic workup consists of a brain imaging study, for a vascular disease or a brain tumour and EEG, for epileptiform discharges. The precise role of EEG in this diagnostic workup has, however, never been clearly delineated. However, this could be crucial in cases of atypical or incomplete presentation with consequences on disease management and treatment. We analysed the EEG patterns on 95 consecutive patients referred for an EEG within 7 days of a TND with diagnostic uncertainty...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143206/characteristics-of-two-distinct-clinical-phenotypes-of-functional-psychogenic-dystonia-follow-up-study
#12
Igor N Petrović, Aleksandra Tomić, Marija Mitković Vončina, Danilo Pešić, Vladimir S Kostić
BACKGROUND: The fixed dystonia phenotype was originally established as a prototype of functional dystonia. Nevertheless, in recent reports different functional dystonia phenotypes have been recognized with dystonic movement comprising phasic instead of tonic contraction. OBJECTIVES: To examine clinical characteristic in all patients with dystonia who fulfilled the criteria for functional movement disorders irrespective of phenotype in an attempt to determine parameters of clinical presentations that might impact the disease progression pattern and outcome...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143205/ugo-cerletti-1877-1963
#13
Stefano Sandrone, Marco Cambiaghi
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29143204/eric-heinz-lenneberg-1921-1975
#14
Elia Zanin, Andrea Moro, Stefano Sandrone
No abstract text is available yet for this article.
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29134272/cxcl13-as-a-diagnostic-marker-of-neuroborreliosis-and-other-neuroinflammatory-disorders-in-an-unselected-group-of-patients
#15
Judith N Wagner, S Weis, C Kubasta, J Panholzer, T J von Oertzen
BACKGROUND: The C-X-C motif chemokine ligand 13 (CXCL13) and its receptor CXCR5 play an important role in the homing of B-lymphocytes. As a biomarker in the cerebrospinal fluid (CSF), CXCL13 has increasingly been used for the diagnosis of neuroborreliosis (NB). We evaluated the diagnostic and prognostic potential of CXCL13 for NB and other neuroinflammatory diseases in an unselected cohort, paying attention to those patients particularly who might benefit from newly emerging CXCL13-directed therapies...
November 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29134271/safety-of-pregnancy-after-cerebral-venous-thrombosis-systematic-review-update
#16
LETTER
Diana Aguiar de Sousa, Patrícia Canhão, José M Ferro
No abstract text is available yet for this article.
November 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29134270/waclaw-blaise-orlowsky-and-his-unacknowledged-discovery-in-neurology
#17
Slawomir Gonkowski, Krystyna Makowska
No abstract text is available yet for this article.
November 13, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29128930/prognostic-value-of-amyloid-pet-scan-in-normal-pressure-hydrocephalus
#18
Hyemin Jang, Seong Beom Park, Yeshin Kim, Ko Woon Kim, Jung Il Lee, Sung Tae Kim, Kyung Han Lee, Eun-Suk Kang, Yeong Sim Choe, Sang Won Seo, Hee Jin Kim, Yeo Jin Kim, Cindy W Yoon, Duk L Na
Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer's disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and negative (iNPH/FBB-) groups were compared with respect to clinical characteristics. We evaluated prognostic value of FBB PET scans by analyzing the response to the tap test using a linear mixed model...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29128929/freezing-of-gait-in-parkinson-s-disease-gray-and-white-matter-abnormalities
#19
Sara Pietracupa, Antonio Suppa, Neeraj Upadhyay, Costanza Giannì, Giovanni Grillea, Giorgio Leodori, Nicola Modugno, Francesca Di Biasio, Alessandro Zampogna, Claudio Colonnese, Alfredo Berardelli, Patrizia Pantano
Freezing of gait (FOG) is a disabling disorder that often affects Parkinson's disease (PD) patients in advanced stages of the disease. To study structural gray matter (GM) and white matter (WM) changes in PD patients with and without FOG, twenty-one PD patients with FOG (PD-FOG), 16 PD patients without FOG (PD-nFOG) and 19 healthy subjects (HS) underwent a standardized MRI protocol. For the gray matter evaluation, cortical volume (CV), cortical thickness (CTh), and surface area (SA) were analyzed using the FreeSurfer pipeline...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29128928/serum-neuron-specific-enolase-may-be-a-marker-to-predict-the-severity-and-outcome-of-cerebral-venous-thrombosis
#20
Yanyu Hu, Ran Meng, Xuxiang Zhang, Linlin Guo, Sijie Li, Yan Wu, Jiangang Duan, Yuchuan Ding, Xunming Ji
The objective is to explore the effective of baseline serum neuron specific enolase (NSE) on predicting the severity and outcome in patients with cerebral venous thrombosis (CVT). A total of 156 patients confirmed as CVT in Xuanwu Hospital were enrolled in this retrospective study from March 2011 through September 2016. The severity was evaluated with the National Institutes of Health Stroke Score (NIHSS), intracranial pressure (ICP), and CVT-related complications; the outcome was evaluated by modified Rankin Scale (mRS); the relationship between baseline serum NSE and mRS was analyzed with receiver operating characteristic curve (ROC), logistic regression analysis, and Kaplan-Meier curves...
November 11, 2017: Journal of Neurology
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