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Journal of Neurology

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https://www.readbyqxmd.com/read/28432430/changes-in-quick-phases-of-downbeat-nystagmus-during-visual-fixation
#1
LETTER
Olympia Kremmyda, Stanislav Bardins, Andreas Straube, Thomas Eggert
No abstract text is available yet for this article.
April 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28424901/driving-with-a-neurodegenerative-disorder-an-overview-of-the-current-literature
#2
REVIEW
Milou Jacobs, Ellen P Hart, Raymund A C Roos
Driving is important for employment, social activities, and for the feeling of independence. The decision to cease driving affects the quality of life and has been associated with reduced mobility, social isolation, and sadness. Patients with neurodegenerative disorders can experience difficulties while driving due to their cognitive, motor, and behavioral impairments. The aim of this review is to summarize the available literature on changes in driving competence and behavior in patients with neurodegenerative disorders, with a particular focus on Huntington's (HD), Parkinson's (PD), and Alzheimer's disease (AD)...
April 19, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28424900/seasonal-variation-in-multiple-sclerosis-relapse
#3
Katharine Harding, Kate Tilling, Claire MacIver, Mark Willis, Fady Joseph, Gillian Ingram, Claire Hirst, Mark Wardle, Trevor Pickersgill, Yoav Ben-Shlomo, Neil Robertson
Relapses are a characteristic clinical feature of multiple sclerosis (MS), but an appreciation of factors that cause them remains elusive. In this study, we have examined seasonal variation of relapse in a large population-based MS cohort and correlated observed patterns with age, sex, disease course, and climatic factors. Relapse data were recorded prospectively in 2076 patients between 2005 and 2014. 3902 events were recorded in 1158 patients (range 0-24). There was significant seasonal variation in relapse rates (p < 0...
April 19, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28424899/a-polysomnographic-study-in-parkinsonian-patients-treated-with-intestinal-levodopa-infusion
#4
Maurizio Zibetti, Alberto Romagnolo, Aristide Merola, Lorenzo Priano, Elisa Montanaro, Serena Angrisano, Antonella Tribolo, Alessandro Cicolin, Leonardo Lopiano
Sleep disorders are very common in advanced Parkinson's disease (PD) and have a significant negative impact on the quality of life of patients. Questionnaire-based studies suggest that sleep quality might improve following levodopa-carbidopa intestinal gel (LCIG) infusion. The objective of this study was to evaluate the impact of LCIG infusion and subsequent oral medication changes on polysomnography (PSG) and sleep symptoms in advanced PD patients. Eleven PD patients underwent PSG at baseline and after 3.8 ± 1...
April 19, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28417192/can-we-predict-benign-multiple-sclerosis-results-of-a-20-year-long-term-follow-up-study
#5
Arianna Sartori, Mohammad Abdoli, Mark S Freedman
Benign multiple sclerosis (MS) is a discussed clinical entity, with variable reported prevalence (6-64%) requiring at least 5-10 years of clinical observation. Moreover, many benign patients progress with time becoming no longer benign (NLB). The objective of this study is to compare benign MS patients (EDSS ≤3, 10 years from disease onset) who still fulfilled the definition at 20 years to those NLB. In our retrospective study based on Ottawa Hospital MS Clinic database, 175 benign patients fulfilled the inclusion criteria (clinically definite MS, EDSS ≤3 at 10 years, disease onset from 1983 to 1993, and clinical assessments performed at 10 ± 1 and 20 ± 1 years from onset)...
April 17, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28401297/familial-dysautonomia-a-disease-with-hidden-tears
#6
LETTER
Carlos E Mendoza-Santiesteban, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann
No abstract text is available yet for this article.
April 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28401296/associations-of-specific-psychiatric-disorders-with-isolated-focal-dystonia-and-monogenic-and-idiopathic-parkinson-s-disease
#7
Susanne Steinlechner, Johann Hagenah, Hans-Jürgen Rumpf, Christian Meyer, Ulrich John, Tobias Bäumer, Norbert Brüggemann, Meike Kasten, Alexander Münchau, Christine Klein, Rebekka Lencer
Comorbidity of psychiatric disorders in patients with movement disorders is common. Often, psychiatric symptoms manifest before the onset of the movement disorder, thus not representing a mere reaction to its burden. How the disease mechanisms of psychiatric and movement disorders are related is still poorly understood. The aim of the present study was to compare prevalence rates of specific psychiatric disorders between different movement disorders including isolated focal dystonia (IFD, N = 91), monogenic Parkinson's disease (PD, N = 41), idiopathic PD (N = 45), and a sample from a Northern Germany general population (TACOS Study; N = 4075)...
April 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28397002/the-uk-myotonic-dystrophy-patient-registry-facilitating-and-accelerating-clinical-research
#8
Libby Wood, Isabell Cordts, Antonio Atalaia, Chiara Marini-Bettolo, Paul Maddison, Margaret Phillips, Mark Roberts, Mark Rogers, Simon Hammans, Volker Straub, Richard Petty, Richard Orrell, Darren G Monckton, Nikoletta Nikolenko, Aura Cecilia Jimenez-Moreno, Rachel Thompson, David Hilton-Jones, Chris Turner, Hanns Lochmüller
Myotonic dystrophy type 1 (DM1) is the most frequent muscular dystrophy worldwide with complex, multi-systemic, and progressively worsening symptoms. There is currently no treatment for this inherited disorder and research can be challenging due to the rarity and variability of the disease. The UK Myotonic Dystrophy Patient Registry is a patient self-enrolling online database collecting clinical and genetic information. For this cross-sectional "snapshot" analysis, 556 patients with a confirmed diagnosis of DM1 registered between May 2012 and July 2016 were included...
April 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28397001/gait-ataxia-in-humans-vestibular-and-cerebellar-control-of-dynamic-stability
#9
Roman Schniepp, Ken Möhwald, Max Wuehr
During human locomotion, vestibular feedback control is fundamental for maintaining dynamic stability and adapting the gait pattern to external circumstances. Within the supraspinal locomotor network, the cerebellum represents the key site for the integration of vestibular feedback information. The cerebellum is further important for the fine-tuning and coordination of limb movements during walking. The aim of this review article is to highlight the shared structural and functional sensorimotor principles in vestibular and cerebellar locomotion control...
April 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28391373/noisy-galvanic-vestibular-stimulation-an-emerging-treatment-option-for-bilateral-vestibulopathy
#10
Max Wuehr, Julian Decker, Roman Schniepp
Patients with bilateral vestibulopathy (BVP) suffer from persistent imbalance during standing and walking as well as an impaired gaze stabilization during head movements. Disabilities associated with BVP severely compromise patients' daily activities and are often linked to an increased risk of falls. Currently, the only established treatment option in BVP is physical therapy. However, treatment effects of physical therapy in BVP are most often limited and many patients do not adequately recover performance...
April 8, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28389742/aortic-hemodynamics-and-white-matter-hyperintensities-in-normotensive-postmenopausal-women
#11
Jill N Barnes, Ronée E Harvey, Samantha M Zuk, Emily S Lundt, Timothy G Lesnick, Jeffrey L Gunter, Matthew L Senjem, Lynne T Shuster, Virginia M Miller, Clifford R Jack, Michael J Joyner, Kejal Kantarci
Hypertension is associated with development of white matter hyperintensities (WMH) in the brain, which are risk factors for mild cognitive impairment. Hormonal shifts at menopause alter vascular function putting women at risk for both hypertension and WMH. Elevations in aortic hemodynamics precede the appearance of clinically defined hypertension but the relationship of aortic hemodynamics to development of WMH in women is not known. Therefore, this study aimed to characterize aortic hemodynamics in relationship to WMH in postmenopausal women...
April 7, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28389741/capturing-saccades-in-multiple-sclerosis-with-a-digitized-test-of-rapid-number-naming
#12
Clotilde Hainline, John-Ross Rizzo, Todd E Hudson, Weiwei Dai, Joel Birkemeier, Jenelle Raynowska, Rachel C Nolan, Lisena Hasanaj, Ivan Selesnick, Teresa C Frohman, Elliot M Frohman, Steven L Galetta, Laura J Balcer, Janet C Rucker
The King-Devick (K-D) test of rapid number naming is a visual performance measure that captures saccadic eye movements. Patients with multiple sclerosis (MS) have slowed K-D test times associated with neurologic disability and reduced quality of life. We assessed eye movements during the K-D test to identify characteristics associated with slowed times. Participants performed a computerized K-D test with video-oculography. The 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) and its 10-Item Neuro-Ophthalmic Supplement measured vision-specific quality of life (VSQOL)...
April 7, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28389740/michael-kremer-1907-1988
#13
J R Silver
No abstract text is available yet for this article.
April 7, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28382420/cerebellar-theta-burst-stimulation-does-not-improve-freezing-of-gait-in-patients-with-parkinson-s-disease
#14
Arno M Janssen, Moniek A M Munneke, Jorik Nonnekes, Thomas van der Kraan, Alice Nieuwboer, Ivan Toni, Anke H Snijders, Bastiaan R Bloem, Dick F Stegeman
Freezing of gait (FOG) in Parkinson's disease (PD) likely results from dysfunction within a complex neural gait circuitry involving multiple brain regions. Herein, cerebellar activity is increased in patients compared to healthy subjects. This cerebellar involvement has been proposed to be compensatory. We hypothesized that patients with FOG would have a reduced ability to recruit the cerebellum to compensate for dysfunction in other brain areas. In this study cerebellar activity was modified unilaterally by either excitatory or inhibitory theta burst stimulation (TBS), applied during two separate sessions...
April 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28382419/a-multicenter-study-on-the-diagnostic-significance-of-a-single-cerebrospinal-fluid-igg-band
#15
Diana Ferraro, Diego Franciotta, Roberta Bedin, Claudio Solaro, Eleonora Cocco, Mario Santangelo, Paolo Immovilli, Alberto Gajofatto, Massimiliano Calabrese, Massimiliano Di Filippo, Riccardo Orlandi, Anna Maria Simone, Francesca Vitetta, Elisabetta Capello, Debora Giunti, Alessandra Murialdo, Jessica Frau, Sara Mariotto, Antongiulio Gallina, Claudio Gasperini, Patrizia Sola
The analysis of paired cerebrospinal fluid (CSF) and serum samples with isolectric focusing (IEF) can yield different patterns which can be of aid in the differential diagnosis of central nervous system (CNS) disorders. Rarely, a single CSF-restricted IgG band, which is not included within these patterns, can be detected in association with inflammatory disorders, multiple sclerosis (MS) above all. However, the diagnostic meaning of this abnormality is still uncertain. The main aim of our multicenter study was to establish the frequency and disease associations of single CSF IgG bands...
April 5, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364298/prevalence-of-parkinson-symptoms-in-patients-with-different-peripheral-vestibular-disorders
#16
LETTER
Sandra Becker-Bense, Constanze Wittmann, Erik van Wensen, Roeland B van Leeuwen, Bastiaan Bloem, Marianne Dieterich
No abstract text is available yet for this article.
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364297/varicella-zoster-virus-encephalitis-in-a-patient-with-a-solid-carcinoma-a-case-report
#17
LETTER
E M Rodenburg, F H Vermeij, M J van den Bent, J M Zuetenhorst
No abstract text is available yet for this article.
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364296/juvenile-onset-myasthenia-gravis-autoantibody-status-clinical-characteristics-and-genetic-polymorphisms
#18
Yu Hong, Geir Olve Skeie, Paraskevi Zisimopoulou, Katerina Karagiorgou, Socrates J Tzartos, Xiang Gao, Yao-Xian Yue, Fredrik Romi, Xu Zhang, Hai-Feng Li, Nils Erik Gilhus
Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against proteins at the neuromuscular junction. Juvenile-onset MG (JMG) has been reported to have special characteristics. It is still unclear whether there are any pathogenic and genetic differences between juvenile and adult MG. In this study, we evaluated the clinical characteristics, autoantibody status (antibodies against AChR, MuSK, LRP4, titin and RyR) and genetic susceptibility (CHRNA1, CTLA4 and AIRE) in 114 Chinese JMG patients, and compared with 207 young adult MG patients (onset age 18-40 years)...
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364295/objective-assessment-of-visual-pursuit-in-patients-with-disorders-of-consciousness-an-exploratory-study
#19
Sarah Wannez, Thomas Hoyoux, Thomas Langohr, Olivier Bodart, Charlotte Martial, Jérôme Wertz, Camille Chatelle, Jacques G Verly, Steven Laureys
Visual pursuit is a key marker of residual consciousness in patients with disorders of consciousness (DOC). Currently, its assessment relies on subjective clinical decisions. In this study, we explore the variability of such clinical assessments, and present an easy-to-use device composed of cameras and video processing algorithms that could help the clinician to improve the detection of visual pursuit in a clinical context. Visual pursuit was assessed by an experienced research neuropsychologist on 31 patients with DOC and on 23 healthy subjects, while the device was used to simultaneously record videos of both one eye and the mirror...
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364294/intermediate-charcot-marie-tooth-disease-an-electrophysiological-reappraisal-and-systematic-review
#20
REVIEW
José Berciano, Antonio García, Elena Gallardo, Kristien Peeters, Ana L Pelayo-Negro, Silvia Álvarez-Paradelo, José Gazulla, Miriam Martínez-Tames, Jon Infante, Albena Jordanova
Charcot-Marie-Tooth disease (CMT) is the most frequent form of inherited neuropathy with great variety of phenotypes, inheritance patterns, and causative genes. According to median motor nerve conduction velocity (MNCV), CMT is divided into demyelinating (CMT1) with MNCV below 38 m/s, axonal (CMT2) with MNCV above 38 m/s, and intermediate CMT with MNCV between 25 and 45 m/s. In each category, transmission may be autosomal dominant, autosomal recessive, or X-linked. The nosology of intermediate CMT is controversial because of concerns about electrophysiological delimitation...
March 31, 2017: Journal of Neurology
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