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Journal of Neurology

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https://www.readbyqxmd.com/read/28921040/euro-esli-a-european-audit-of-real-world-use-of-eslicarbazepine-acetate-as-a-treatment-for-partial-onset-seizures
#1
Vicente Villanueva, Martin Holtkamp, Norman Delanty, Juan Rodriguez-Uranga, Rob McMurray, Patricia Santagueda
The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assessed after 3, 6, and 12 months of ESL treatment, and at the final visit. Safety and tolerability were assessed throughout ESL treatment by evaluating adverse events (AEs) and ESL discontinuation due to AEs...
September 18, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28921038/efficacy-and-safety-of-tacrolimus-for-myasthenia-gravis-a-systematic-review-and-meta-analysis
#2
REVIEW
Liang Wang, Suxian Zhang, Jianying Xi, Wenhui Li, Lei Zhou, Jun Lu, Jiahong Lu, Tiansong Zhang, Chongbo Zhao
To evaluate the efficacy and safety of tacrolimus in patients with myasthenia gravis (MG), a systematic review and meta-analysis was performed. We searched PubMed and Embase for randomized controlled trials and clinical controlled trials in English language. Demographic and clinical characteristics of the MG patients were extracted. Differences in the current glucocorticoids (GC) dose in each included study were the primary outcome measure. The adverse events reported in each included study were used as safety evaluation...
September 18, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28914354/comorbidity-of-dementia-with-amyotrophic-lateral-sclerosis-als-insights-from-a-large-multicenter-italian-cohort
#3
Francesca Trojsi, Mattia Siciliano, Cinzia Femiano, Gabriella Santangelo, Christian Lunetta, Andrea Calvo, Cristina Moglia, Kalliopi Marinou, Nicola Ticozzi, Gianluca Drago Ferrante, Carlo Scialò, Gianni Sorarù, Amelia Conte, Yuri M Falzone, Rosanna Tortelli, Massimo Russo, Valeria Ada Sansone, Adriano Chiò, Gabriele Mora, Barbara Poletti, Paolo Volanti, Claudia Caponnetto, Giorgia Querin, Mario Sabatelli, Nilo Riva, Giancarlo Logroscino, Sonia Messina, Antonio Fasano, Maria Rosaria Monsurrò, Gioacchino Tedeschi, Jessica Mandrioli
To assess the association, at diagnosis, between amyotrophic lateral sclerosis (ALS) and dementia in a large cohort of well-characterized Italian patients. We investigated the phenotypic profile of 1638 incident patients with definite, probable or laboratory-supported probable ALS, diagnosed from January 2009 to December 2013 in 13 Italian Referral Centers, located in 10 Italian Regions, and classified in two independent subsamples accounting for presence or not of dementia. The collected ALS features, including survival and other follow-up data, were compared between the two subgroups using a one-way analysis of variance and Chi-square test, as appropriate, logistic regression models and Kaplan-Meier survival analysis...
September 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28914353/optic-neuritis-in-patients-with-anti-mog-antibodies-spectrum-disorder-mri-and-clinical-features-from-a-large-multicentric-cohort-in-france
#4
LETTER
Damien Biotti, Fabrice Bonneville, Emilie Tournaire, Xavier Ayrignac, Clarisse Carra Dallière, Laurence Mahieu, Catherine Vignal, Cecile Dulau, Bruno Brochet, Aurélie Ruet, Jean-Christophe Ouallet, Olivier Gout, Françoise Heran, Nicolas Menjot de Champfleur, Thomas Tourdias, Marc Deneve, Pierre Labauge, Romain Deschamps
No abstract text is available yet for this article.
September 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28900724/hypothalamic-dysfunction-is-related-to-sleep-impairment-and-csf-biomarkers-in-alzheimer-s-disease
#5
Claudio Liguori, Agostino Chiaravalloti, Marzia Nuccetelli, Francesca Izzi, Giuseppe Sancesario, Andrea Cimini, Sergio Bernardini, Orazio Schillaci, Nicola Biagio Mercuri, Placidi Fabio
Hypothalamus is a key brain region regulating several essential homeostatic functions, including the sleep-wake cycle. Alzheimer's disease (AD) pathology affects nuclei controlling sleep-wake rhythm sited in this brain area. Since only post-mortem studies documented the relationship between hypothalamic atrophy and sleep-wake cycle impairment, we investigated in AD patients the possible hypothalamic in vivo alteration using 2-deoxy-2-(18F) fluoro-D-glucose ([18F]FDG) positron emission tomography ([18F]FDG PET), and its correlations with sleep impairment and cerebrospinal-fluid (CSF) AD biomarkers (tau proteins and β-amyloid42)...
September 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28894952/characterization-of-brain-tumours-with-spin-spin-relaxation-pilot-case-study-reveals-unique-t-2-distribution-profiles-of-glioblastoma-oligodendroglioma-and-meningioma
#6
Cornelia Laule, Thorarin A Bjarnason, Irene M Vavasour, Anthony L Traboulsee, G R Wayne Moore, David K B Li, Alex L MacKay
Prolonged spin-spin relaxation times in tumour tissue have been observed since some of the earliest nuclear magnetic resonance investigations of the brain. Over the last three decades, numerous studies have sought to characterize tumour morphology and malignancy using quantitative assessment of T 2 relaxation times, although attempts to categorize and differentiate tumours have had limited success. However, previous work must be interpreted with caution as relaxation data were typically acquired using a variety of multiple echo sequences with a range of echoes and T 2 decay curves and were frequently fit with monoexponential analysis...
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28894947/thalamic-transitory-ischemic-attacks-presenting-as-jacksonian-sensory-march
#7
Victoria Schubert, Stephan Lauxmann, Benjamin Bender, Holger Lerche
Spreading somatosensory symptoms appearing as Jacksonian sensory march are usually considered to be due to an epileptic seizure. We report on three cases in which these symptoms were caused by thalamic ischemia. Two patients presented with stereotypically recurring hemiparesthesias lasting 2-5 min that gradually spread from the face to the arm and leg on one side. A first cerebral magnetic resonance imaging including DWI was negative in both cases, whereas new thalamic infarctions appeared on repeated imaging when clinical symptoms remained...
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28894929/recalling-feature-bindings-differentiates-alzheimer-s-disease-from-frontotemporal-dementia
#8
Mario Amore Cecchini, Mônica Sanches Yassuda, Valéria Santoro Bahia, Leonardo Cruz de Souza, Henrique Cerqueira Guimarães, Paulo Caramelli, Maria Teresa Carthery-Goulart, Flávia Patrocínio, Maria Paula Foss, Vitor Tumas, Thaís Bento Lima-Silva, Sônia Maria Dozzi Brucki, Ricardo Nitrini, Sergio Della Sala, Mario A Parra
It has been challenging to identify clinical cognitive markers that can differentiate patients with Alzheimer's disease (AD) from those with behavioral variant frontotemporal dementia (bvFTD). The short-term memory binding (STMB) test assesses the ability to integrate colors and shapes into unified representations and to hold them temporarily during online performance. The objective of this study is to investigate whether free recall deficits during short-term memory binding (STMB) test can differentiate patients with AD from those with bvFTD and controls...
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28894926/brainstem-stroke-preceded-by-transient-isolated-vertigo-attacks
#9
LETTER
G M Halmagyi
No abstract text is available yet for this article.
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28894919/-timed-up-and-go-and-brain-atrophy-a-preliminary-mri-study-to-assess-functional-mobility-performance-in-multiple-sclerosis
#10
Lorena Lorefice, G Coghe, G Fenu, M Porta, G Pilloni, J Frau, F Corona, V Sechi, M A Barracciu, M G Marrosu, M Pau, E Cocco
Motor and cognitive disabilities are related to brain atrophy in multiple sclerosis (MS). 'Timed up and go' (TUG) has been recently tested in MS as functional mobility test, as it is able to evaluate ambulation/coordination-related tasks, as well as cognitive function related to mobility. The objective of this study is to evaluate the relationship between brain volumes and TUG performances. Inclusion criteria were a diagnosis of MS and the ability to walk at least 20 m. TUG was performed using a wearable inertial sensor...
September 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28887620/bilateral-parotid-gland-hemorrhage-after-intravenous-thrombolysis-for-stroke-treatment
#11
LETTER
Ana Catarina Fonseca, Ana Catarina Franco, Joana Tavares
No abstract text is available yet for this article.
September 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28879451/prognostic-factors-and-disease-course-in-aquaporin-4-antibody-positive-chinese-patients-with-acute-optic-neuritis
#12
Hao Kang, Tingjun Chen, Hongyang Li, Quangang Xu, Shanshan Cao, Shihui Wei
The objective is to assess the frequency of AQP4-Ab in Chinese patients with optic neuritis (ON) and to investigate the prognostic implications of AQP4-Ab seropositivity in such patients. The presence of aquaporin-4 (AQP4) antibodies in human AQP4-transfected cells was determined by indirect immunofluorescence, and the diagnostic and prognostic relevance of AQP4 antibodies in 215 Chinese patients with optic neuritis was evaluated. The patients were enrolled from the Chinese People's Liberation Army General Hospital (PLAGH) and followed up to 1-228 months...
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28879446/parkinsonian-symptoms-in-normal-pressure-hydrocephalus-a-population-based-study
#13
Karin Molde, Lars Söderström, Katarina Laurell
It may be challenging to differentiate normal pressure hydrocephalus (NPH) from neurodegenerative disorders such as Parkinson's disease. In this population-based study, we wanted to describe the frequency of parkinsonian symptoms among individuals with and without NPH, and whether the motor examination part of the Unified Parkinson's Disease Rating Scale (UPDRS-m) score differs between these groups. Furthermore, we wanted to find out whether there was a relationship between UPDRS-m score, NPH symptoms, and radiological signs of NPH...
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28879438/do-cognition-and-other-non-motor-symptoms-decline-similarly-among-patients-with-parkinson-s-disease-motor-subtypes-findings-from-a-5-year-prospective-study
#14
L Arie, Talia Herman, S Shema-Shiratzky, N Giladi, J M Hausdorff
Among patients with Parkinson's disease (PD), a wide range of motor and non-motor symptoms (NMS) are evident. PD is often divided into tremor dominant (TD) and postural instability gait difficulty (PIGD) motor subtypes. We evaluated the effect of disease duration and aimed to characterize whether there are differences in the deterioration of cognitive function and other NMS between the PIGD and TD subtypes. Sixty-three subjects were re-evaluated at the follow-up visit about 5 years after baseline examination...
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28879426/cerebral-amyloid-angiopathy-subtypes-treatment-and-role-in-cognitive-impairment
#15
D McLauchlan, G A Malik, N P Robertson
No abstract text is available yet for this article.
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28879412/the-sequence-of-disease-modifying-therapies-in-relapsing-multiple-sclerosis-safety-and-immunologic-considerations
#16
REVIEW
Gabriel Pardo, David E Jones
The treatment landscape for relapsing forms of multiple sclerosis (RMS) has expanded considerably over the last 10 years with the approval of multiple new disease-modifying therapies (DMTs), and others in late-stage clinical development. All DMTs for RMS are believed to reduce central nervous system immune-mediated inflammatory processes, which translate into demonstrable improvement in clinical and radiologic outcomes. However, some DMTs are associated with long-lasting effects on the immune system and/or serious adverse events, both of which may complicate the use of subsequent therapies...
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28879396/vestibulo-ocular-reflex-deficits-with-medial-longitudinal-fasciculus-lesions
#17
Swee T Aw, Luke Chen, Michael J Todd, Michael H Barnett, G Michael Halmagyi
The medial longitudinal fasciculus (MLF) is the final common pathway for all conjugate adducting horizontal eye movements, as well as for the vertical-torsional vestibulo-ocular reflex (VOR). MLF lesion causes adduction paresis of ipsilesional (adducting) eye with dissociated nystagmus of contralesional (abducting) eye-the well-known clinical syndrome of internuclear ophthalmoplegia (INO). We measured the VOR stimulation and also any catch-up saccades, from individual semicircular canal (SCC) evoked by the head impulse test (HIT), using head and binocular 3-dimensional scleral search coils in 27 multiple sclerosis (MS) patients, 8 with unilateral, 19 with bilateral INO...
September 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28856477/editorial-supplement-dizzynet-2017
#18
EDITORIAL
Andreas Zwergal, Hans Straka, Thomas Brandt, Michael Strupp
No abstract text is available yet for this article.
August 30, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28856460/late-onset-pompe-disease-a-genetic-radiological-correlation-on-cerebral-vascular-anomalies
#19
A Pichiecchio, S Sacco, P De Filippi, E Caverzasi, S Ravaglia, S Bastianello, C Danesino
Pompe disease is an autosomal recessive disorder in which deficiency of the lysosomal enzyme acid alpha-glucosidase results in the accumulation of glycogen mostly in muscle tissues. Several reports suggest a higher incidence of intracranial vascular abnormalities (IVAs) in this condition, as well as brain microbleeds and cerebral vasculopathy. The aim of our study was to evaluate through neuroimaging studies the incidence of these anomalies in our cohort of late-onset Pompe disease (LOPD) patients asymptomatic for cerebrovascular disease, looking for correlations with clinical and genetic data...
August 30, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28856425/a-specific-pattern-of-gray-matter-atrophy-in-alzheimer-s-disease-with-depression
#20
Efstratios Karavasilis, Theodore P Parthimos, John D Papatriantafyllou, Sokratis G Papageorgiou, George Kapsas, Andrew C Papanicolaou, Ioannis Seimenis
Considering the high incidence of depressive symptoms in Alzheimer's disease (AD), we conducted a large-sample study to investigate the pattern of gray matter (GM) abnormalities that differentiates depressive from non-depressive AD patients. We included 201 AD patients who underwent MRI assessment and categorized them into depressive and non-depressive subgroups based on the Geriatric Depression Scale (GDS; cut-off score: ≤9). We performed whole-brain voxel-based morphometry analysis in 173 patients after MRI quality control and used between-group comparisons and regression analysis models to analyze the volumetric data controlling for nuisance variables...
August 30, 2017: Journal of Neurology
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