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Journal of Neurology

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https://www.readbyqxmd.com/read/28785799/genetics-of-disease-severity-in-multiple-sclerosis-alzheimer-s-disease-and-huntington-s-disease-rejuvenating-genome-wide-association-studies
#1
James Hrastelj, Neil Robertson
No abstract text is available yet for this article.
August 7, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28785798/high-prevalence-of-neuronal-surface-autoantibodies-associated-with-cognitive-deficits-in-cancer-patients
#2
Carsten Finke, Frederik Bartels, Alva Lütt, Harald Prüss, Lutz Harms
The recent discovery of neuronal cell-surface antibodies profoundly expanded the clinical spectrum of paraneoplastic neurological syndromes. Many of these syndromes are associated with impaired cognitive function, a clinical symptom that is of increasing concern in cancer patients. However, the frequency of these antibodies in cancer patients and their relation to clinical syndromes is currently unknown. Here, we investigated the prevalence of neuronal cell-surface antibodies and associated paraneoplastic neurological syndromes in 323 patients with different cancer types and in 105 controls...
August 7, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28770375/severity-of-traumatic-brain-injury-correlates-with-long-term-cardiovascular-autonomic-dysfunction
#3
Max J Hilz, Ruihao Wang, Jörg Markus, Fabian Ammon, Katharina M Hösl, Steven R Flanagan, Klemens Winder, Julia Koehn
After traumatic brain injury (TBI), central autonomic dysfunction might contribute to long-term increased mortality rates. Central autonomic dysfunction might depend on initial trauma severity. This study was performed to evaluate differences in autonomic modulation at rest and upon standing between patients with a history of mild TBI (post-mild-TBI patients), moderate or severe TBI (post-moderate-severe-TBI patients), and healthy controls. In 20 post-mild-TBI patients (6-78 months after TBI), age-matched 20 post-moderate-severe-TBI patients (6-94 months after TBI) and 20 controls, we monitored respiration, RR intervals (RRI) and systolic blood pressure (BPsys) at supine rest and upon standing...
August 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28770374/mog-antibody-related-disorders-common-features-and-uncommon-presentations
#4
Álvaro Cobo-Calvo, Anne Ruiz, Hyacintha D'Indy, Anne-Lise Poulat, Maryline Carneiro, Nicolas Philippe, Françoise Durand-Dubief, Kumaran Deiva, Sandra Vukusic, Vincent Desportes, Romain Marignier
Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been reported in acute demyelinating encephalomyelitis (ADEM), optic neuritis (ON), and neuromyelitis optica spectrum disorders (NMOSD) in adults and pediatrics. We aimed to delineate the common features of MOG-Ab-related disorders in children and adults, and report uncommon presentations. Twenty-seven consecutive pediatric and adult patients testing positive for MOG-Ab, with a minimum follow-up of 6 months, were included. Comprehensive epidemiological, clinical, radiological, and laboratory data were retrospectively analyzed...
August 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28770373/early-predictive-factors-of-disability-in-cidp
#5
Emanuele Spina, Antonietta Topa, Rosa Iodice, Stefano Tozza, Lucia Ruggiero, Raffaele Dubbioso, Marcello Esposito, Dario Bruzzese, Lucio Santoro, Fiore Manganelli
The objective of this study was to identify early clinical, biochemical and electrophysiological prognostic factors of disability in CIDP. We evaluated a dataset from 60 CIDP patients that included sex, age of onset, type of onset, phenotype, disease duration, response to treatment, disability at the time of diagnosis assessed using the modified Rankin Scale (baseline mRS), cerebrospinal fluid protein levels and electrophysiological data. All patients had clinical assessment of disability through the mRS within the last 6 months (last mRS) before enrollment in the study...
August 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28770372/the-impact-of-anger-in-adherence-to-treatment-and-beliefs-about-disease-1%C3%A2-year-after-stroke
#6
A Catarina Santos, José M Ferro
Anger is a frequent neuropsychiatric symptom after stroke, which can disrupt treatment and recovery, in particular by affecting adherence behaviour to treatment and health care education. This study aimed to follow-up a cohort of stroke patients 12 months after their stroke to describe the presence of anger, compare levels and profile of acute and post-acute anger and analyse its impact on the adherence to treatment and beliefs about stroke. We followed (13.3 months mean follow-up) 91 stroke patients with a standardized protocol, using State-Trait Anger Expression Inventory-2 (STAXI-2) to assess the frequency and profile of anger and its components and one questionnaire to measure adherence to treatment and health education (meaning on the treatment) (Adh-T)...
August 2, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28762086/regional-microstructural-damage-and-patterns-of-eye-movement-impairment-a-dti-and-video-oculography-study-in-neurodegenerative-parkinsonian-syndromes
#7
Martin Gorges, Melanie N Maier, Johannes Rosskopf, Olga Vintonyak, Elmar H Pinkhardt, Albert C Ludolph, Hans-Peter Müller, Jan Kassubek
Characteristic alterations of eye movement control are a common feature of neurodegenerative parkinsonism, including Parkinson's disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA). Regional microstructural alterations as assessed by diffusion tensor imaging (DTI) have been reported in PD, PSP, and MSA. Therefore, we investigated the specific association between eye movement disturbances and microstructural impairment in these diseases. Video-oculographic recordings of smooth pursuit and visually guided reactive saccades as well as fractional anisotropy (FA) maps computed from whole-brain DTI data were analyzed for 36 PD, 30 PSP, 18 MSA patients, and 23 matched healthy control subjects...
July 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28756606/a-novel-imaging-technique-for-better-detecting-new-lesions-in-multiple-sclerosis
#8
Paul Eichinger, Hanni Wiestler, Haike Zhang, Viola Biberacher, Jan S Kirschke, Claus Zimmer, Mark Mühlau, Benedikt Wiestler
We developed a tool that performs longitudinal subtraction of 3D double inversion recovery (DIR) images in follow-up magnetic resonance (MR) examinations of patients with multiple sclerosis. As DIR sequences show a high lesion-to-parenchyma contrast, we hypothesized that such a tool might lead to increased sensitivity for new lesions as well as to speeding up the routine clinical work-up of follow-up MR imaging in multiple sclerosis by directly visualizing new lesions. DIR subtraction images of serial MR examinations were calculated in 106 patients with multiple sclerosis...
July 29, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28756605/magnetic-resonance-imaging-of-leg-muscles-in-patients-with-myotonic-dystrophies
#9
Stojan Peric, Ruzica Maksimovic, Bojan Banko, Milica Durdic, Bogdan Bjelica, Ivo Bozovic, Yunus Balcik, Jovan Pesovic, Dusanka Savic-Pavicevic, Vidosava Rakocevic-Stojanovic
Magnetic resonance imaging (MRI) of muscles has recently become a significant diagnostic procedure in neuromuscular disorders. There is a lack of muscle MRI studies in patients with myotonic dystrophy type 1 (DM1), especially type 2 (DM2). To analyze fatty infiltration of leg muscles, using 3.0 T MRI in patients with genetically confirmed DM1 and DM2 with different disease durations. The study comprised 21 DM1 and 10 DM2 adult patients. Muscle MRI was performed in axial plane of the lower limbs using T1-weighted (T1w) sequence...
July 29, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28756604/henri-meige-1866-1940
#10
Michał K Owecki, Halina Bogusz, Anita Magowska
No abstract text is available yet for this article.
July 29, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28755307/switch-to-semont-maneuver-is-no-better-than-repetition-of-epley-maneuver-in-treating-refractory-bppv
#11
Sun-Young Oh, Ji-Soo Kim, Kwang-Dong Choi, Ji-Yun Park, S-H Jeong, Seung-Han Lee, Hak-Seung Lee, Tae-Ho Yang, H-J Kim
The objectives of this study is to compare the efficacy between repetition of Epley maneuver and switch to alternate Semont maneuver in treating posterior canal benign paroxysmal positional vertigo (PC-BPPV) that does not respond to the initial Epley maneuver. In the nationwide, seven dizziness clinics of Korea, 506 consecutive patients (303 women, age range 22-87, mean age ± SD = 64 ± 12, median = 61) with idiopathic PC-BPPV were initially treated with a single Epley maneuver. Of those, 144 (28.5%) patients, who did not respond to the therapy, were randomized to the repetition of Epley maneuver (n = 70) or switch to Semont maneuver (n = 74)...
July 28, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28752238/exome-sequencing-reveals-a-novel-homozygous-mutation-in-acp33-gene-in-the-first-italian-family-with-spg21
#12
LETTER
Marina Scarlato, Andrea Citterio, Alessandra Barbieri, Claudia Godi, Elena Panzeri, Maria Teresa Bassi
No abstract text is available yet for this article.
July 27, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28744762/mortality-after-primary-intracerebral-hemorrhage-in-relation-to-post-stroke-seizures
#13
Danny Claessens, Kim Bekelaar, Floris H B M Schreuder, Bianca T A de Greef, Mariëlle C G Vlooswijk, Julie Staals, Robert J van Oostenbrugge, Rob P W Rouhl
Seizures after intracerebral hemorrhage are repeatedly seen. Whether the development of seizures after intracerebral hemorrhage affects survival in the long term is unknown. This study aims to determine the relation between seizures (i.e., with and without anti-epileptic therapy) and long-term mortality risk in a large patient population with intracerebral hemorrhage. We retrospectively included patients with a non-traumatic ICH in all three hospitals in the South Limburg region in the Netherlands between January 1st 2004 and December 31st 2009, and we assessed all-cause mortality until March 14th 2016...
July 25, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28730571/early-trigeminal-nerve-involvement-in-listeria-monocytogenes-rhombencephalitis-case-series-and-systematic-review
#14
William K Karlsson, Zitta Barrella Harboe, Casper Roed, Jeppe B Monrad, Mette Lindelof, Vibeke Andrée Larsen, Daniel Kondziella
Listeria monocytogenes is associated with rhombencephalitis. However, the exact mechanisms of brainstem invasion remains poorly understood. Here, we demonstrate clinical and radiological data suggesting that Listeria may invade the brainstem via the trigeminal nerve. Three females (41, 64 and 70 years) with culture proven L. monocytogenes bacteremia and rhombencephalitis were investigated in the period of 2014-16. T2-weighted and contrast-enhanced T1-weighted MRI revealed a cerebellopontine abscess in all three patients, including the involvement of the trigeminal nerve root...
July 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28730570/structural-connectivity-differences-in-essential-tremor-with-and-without-resting-tremor
#15
Maria Eugenia Caligiuri, Gennarina Arabia, Gaetano Barbagallo, Angela Lupo, Maurizio Morelli, Rita Nisticò, Fabiana Novellino, Andrea Quattrone, Maria Salsone, Basilio Vescio, Andrea Cherubini, Aldo Quattrone
In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello-thalamo-basal ganglia-cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and twenty-five age- and sex-matched healthy controls were included in the study. All participants underwent whole-brain 3D T1-weighted and diffusion-weighted MRI, and DAT-SPECT. Probabilistic tractography was performed on diffusion data in network mode, reconstructing connections between the different structures of the cerebello-thalamo-basal ganglia-cortical loop...
July 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28711999/erratum-to-progressive-multifocal-leukoencephalopathy-in-patients-treated-with-fumaric-acid-esters-a-review-of-19-cases
#16
Robbert-Jan Gieselbach, Annemarie H Muller-Hansma, Martijn T Wijburg, Marjolein S de Bruin-Weller, Bob W van Oosten, Dennis J Nieuwkamp, Frank E Coenjaerts, Mike P Wattjes, Jean-Luc Murk
No abstract text is available yet for this article.
July 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28695360/erratum-to-lambert-eaton-myasthenic-syndrome-lems-a-rare-autoimmune-presynaptic-disorder-often-associated-with-cancer
#17
Benedikt Schoser, Bruno Eymard, Joe Datt, Renato Mantegazza
No abstract text is available yet for this article.
July 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28669118/quantifying-fat-replacement-of-muscle-by-quantitative-mri-in-muscular-dystrophy
#18
REVIEW
Jedrzej Burakiewicz, Christopher D J Sinclair, Dirk Fischer, Glenn A Walter, Hermien E Kan, Kieren G Hollingsworth
The muscular dystrophies are rare orphan diseases, characterized by progressive muscle weakness: the most common and well known is Duchenne muscular dystrophy which affects young boys and progresses quickly during childhood. However, over 70 distinct variants have been identified to date, with different rates of progression, implications for morbidity, mortality, and quality of life. There are presently no curative therapies for these diseases, but a range of potential therapies are presently reaching the stage of multi-centre, multi-national first-in-man clinical trials...
July 1, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28608304/lambert-eaton-myasthenic-syndrome-lems-a-rare-autoimmune-presynaptic-disorder-often-associated-with-cancer
#19
REVIEW
Benedikt Schoser, Bruno Eymard, Joe Datt, Renato Mantegazza
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular junction disorder that is related to the loss of functional P/Q-type voltage-gated calcium channels (VGCCs) on presynaptic nerve terminals. Up to 60% of cases occur as a paraneoplastic disorder (SCLC-LEMS), most commonly in association with small cell lung cancer. The remaining cases have an idiopathic non-tumor etiology but are associated with underlying autoimmune disease (NT-LEMS). Patients with LEMS invariably experience progressive proximal muscle weakness, often accompanied by general fatigue and autonomic symptoms...
June 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28567539/retinal-ganglion-cell-analysis-in-multiple-sclerosis-and-optic-neuritis-a-systematic-review-and-meta-analysis
#20
REVIEW
Josefine Britze, Gorm Pihl-Jensen, Jette Lautrup Frederiksen
The aim of this study was to summarise existing findings regarding optical coherence tomography (OCT) measurements of ganglion cell layer (GCL) alterations in optic neuritis (ON) and multiple sclerosis (MS). Peer-reviewed studies published prior to April 2016 were searched using PubMed, EMBASE, Web of Science and Scopus. Studies were included if they measured GCL thickness using OCT in patients with either ON, MS or clinically isolated syndrome. For the meta-analysis, we compared GCL thickness in MS patients with and without prior ON, to healthy controls...
May 31, 2017: Journal of Neurology
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