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Journal of Neurology

Simonetta Galgani, Luca Prosperini, Shalom Haggiag, Carla Tortorella, Claudio Gasperini
No abstract text is available yet for this article.
July 17, 2018: Journal of Neurology
Marianna Amboni, Luigi Iuppariello, Alessandro Iavarone, Alfonso Fasano, Raffaele Palladino, Rosaria Rucco, Marina Picillo, Ilaria Lista, Pasquale Varriale, Carmine Vitale, Mario Cesarelli, Giuseppe Sorrentino, Paolo Barone
Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict subsequent cognitive impairment in Parkinson's disease (PD). We evaluated cognition and gait in 39 Parkinsonian patients at an initial assessment and after 3 years. Cognitive performance was evaluated with a neuropsychological battery designed to assess memory, executive/attention, and visuospatial domains...
July 16, 2018: Journal of Neurology
Omar Hussein, Khalid Sawalha, Mohammad Hamed, Ahmed Abd ElAzim, Lai Wei, Michel T Torbey, Archana Hinduja
BACKGROUND: The presence of the spot sign on computed tomography angiogram (CTA) is considered a sign of active bleeding, and studies have shown it can predict hematoma expansion in intraparenchymal hemorrhage (IPH). The spot sign in intraventricular hemorrhage (IVH) has not been explored yet. The purpose of this study is to estimate the prevalence of the intraventricular-spot sign, and its prediction of hematoma expansion and clinical outcomes. METHODS: We retrieved data of hemorrhagic stroke patients seen at our medical center from January 2013 to January 2018...
July 16, 2018: Journal of Neurology
Moisés León Ruiz, Miguel Á García-Soldevilla, Esteban García-Albea Ristol
No abstract text is available yet for this article.
July 13, 2018: Journal of Neurology
Marianthi Breza, Georgios Koutsis
Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a rare, X-linked hereditary lower motor neuron disease, characterized by progressive muscular weakness. An expanded trinucleotide repeat (CAG > 37) in the androgen receptor gene (AR), encoding glutamine, is the mutation responsible for Kennedy's disease. Toxicity of this mutant protein affects both motor neurons and muscles. In this review, we provide a comprehensive, clinically oriented overview of the current literature regarding Kennedy's disease, highlighting gaps in our knowledge that remain to be addressed in further research...
July 13, 2018: Journal of Neurology
Chloé Bost, Eve Chanson, Géraldine Picard, David Meyronet, Marie-Eve Mayeur, François Ducray, Veronique Rogemond, Dimitri Psimaras, Jean-Christophe Antoine, Jean-Yves Delattre, Virginie Desestret, Jerome Honnorat
OBJECTIVE: The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor. METHODS: Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors...
July 12, 2018: Journal of Neurology
Rani A Sarkis, Yazel Goksen, Yi Mu, Bernard Rosner, Jong Woo Lee
We aimed to investigate the terms used to refer to cognitive and fatigue related side effects and their prevalence in phase III add-on clinical trials of anti-epileptic drugs (AEDs). We extracted data from publicly available FDA documents as well as the published literature. Target drug doses were then calculated as drug loads and divided into three categories (low, average, high). The odds ratio of developing the side effects was calculated for each drug load, and the presence of a dose-response effect was also assessed...
July 12, 2018: Journal of Neurology
N Ahmad Aziz, Patrick Weydt
No abstract text is available yet for this article.
July 12, 2018: Journal of Neurology
Yolanda Aladro, Laudino López-Alvarez, Jorge Mario Sánchez-Reyes, Juan Antonio Hernández-Tamames, Helena Melero, Sandra Rubio-Fernández, Israel Thuissard, Marta Cerezo-García
BACKGROUND/OBJECTIVE: Two functional networks are proposed as neuronal support for the complex processes of memory: the anterior temporal and the medial posterior systems. We examined the atrophy of hippocampus (HC) and of those areas constituting the two functional memory systems in multiple sclerosis (MS) patients with low disability. METHODS: Episodic memory (EM) was assessed in 88 relapsing MS patients and in 40 healthy controls using Wechsler Memory Scale III (Spanish adaptation)...
July 11, 2018: Journal of Neurology
Maryse Feron, Annabelle Couillandre, Eya Mseddi, Nicolas Termoz, Malek Abidi, Eric Bardinet, Daniel Delgadillo, Timothée Lenglet, Giorgia Querin, Marie-Laure Welter, Nadine Le Forestier, François Salachas, Gaelle Bruneteau, Maria Del Mar Amador, Rabab Debs, Lucette Lacomblez, Vincent Meininger, Mélanie Pélégrini-Issac, Peter Bede, Pierre-François Pradat, Giovanni de Marco
INTRODUCTION: Extrapyramidal deficits are poorly characterised in amyotrophic lateral sclerosis (ALS) despite their contribution to functional disability, increased fall risk and their quality-of-life implications. Given the concomitant pyramidal and cerebellar degeneration in ALS, the clinical assessment of extrapyramidal features is particularly challenging. OBJECTIVE: The comprehensive characterisation of postural instability in ALS using standardised clinical assessments, gait analyses and computational neuroimaging tools in a prospective study design...
July 11, 2018: Journal of Neurology
Eldbjørg Hustad, Anne Heidi Skogholt, Kristian Hveem, Jan O Aasly
Diagnostic accuracy is crucial not only for prognostic and therapeutic reasons, but also for epidemiologic studies. We aimed to study the accuracy of the clinical diagnosis of Parkinson disease (PD) for participants in The Nord-Trøndelag Health Study (HUNT), a health survey, containing data from approximately 126,000 individuals and biological material from 80,000 individuals. We included 980 participants from the HUNT study diagnosed with PD or secondary parkinsonism/related parkinsonian disorders. The participants had been diagnosed in conjunction with admission to hospitals in Trøndelag or through out-patient examination...
July 10, 2018: Journal of Neurology
M D Willis, N P Robertson
No abstract text is available yet for this article.
July 10, 2018: Journal of Neurology
Rodica Di Lorenzo, Karin Mente, Jianbo Li, Luay Shayya, Alexander Rae-Grant, Yuebing Li, Adham Jammoul
As testing for neuronal antibodies become more readily available, the spectrum of conditions potentially associated with these autoantibodies has been widening. Voltage-gated calcium channel antibodies (VGCC-Ab) are no exception to this trend. The significance of an elevated VGCC-Ab titer beyond its original clinicopathological correlate, Lambert-Eaton myasthenic syndrome (LEMS) remains undetermined. We sought to determine the diagnostic significance of an elevated serum VGCC-Ab titer in a large single-center cohort of 100 patients...
July 9, 2018: Journal of Neurology
Karmele Olaciregui Dague, R Surges, J Litmathe, L Villa, J Brokmann, J B Schulz, M Dafotakis, O Matz
AIM: The differentiation between epileptic and non-epileptic episodes can be challenging. Our aim was to compare lactate, anion gap (AG), bicarbonate and the Denver Seizure Score (DSS) as point-of-care test (POCT) markers for episodes of transient alterations of consciousness. METHODS: The blood serum parameters were drawn at arrival in the emergency department (ED) within 2 h of the episode. After calculating AG and DSS values, the four parameters were compared retrospectively between patients with generalized tonic-clonic seizures (GTCS) (n = 165) and patients with other disorders of consciousness [syncopes (n = 43), and psychogenic non-epileptic seizures (n = 15)]...
July 9, 2018: Journal of Neurology
Libin Xiao, Lizhen Pan, Bing Li, Yanwen Zhou, Yougui Pan, Xiaolong Zhang, Yong Hu, Dirk Dressler, Lingjing Jin
Botulinum toxin (BT) is the treatment of choice for hemifacial spasm (HFS). When BT is injected into the affected side, patients may experience increased facial asymmetry. We wanted to evaluate in a prospective, randomised, placebo-controlled study whether bilateral BT injections may reduce this facial asymmetry. For this, we treated 19 HFS patients with unilateral and 24 with bilateral BT therapy using CBTX-A (Lanzhou Biological Products Institute, Lanzhou, China). BT doses on the affected side were standard doses, on the non-affected side they were one-third of those...
July 9, 2018: Journal of Neurology
Michael Strupp, Thomas Brandt, Doreen Huppert, Eva Grill
No abstract text is available yet for this article.
July 7, 2018: Journal of Neurology
José Berciano, Nuria Terán-Villagrá
No abstract text is available yet for this article.
July 6, 2018: Journal of Neurology
Silvia Picazio, Viviana Ponzo, Carlo Caltagirone, Livia Brusa, Giacomo Koch
INTRODUCTION: Chronic dopamine replacement therapies in Parkinson's disease can induce side effects, such as levodopa-induced dyskinesias and impulse control disorders. A dysfunction of inhibitory brain networks has been related to both disorders; however, there is no clear behavioral evidence supporting this hypothesis. We aimed to determine whether PD patients with levodopa-induced dyskinesias show features of increased impulsivity in parallel with altered motor inhibition. METHODS: Two matched samples of Parkinson's disease patients with (n = 14) or without (n = 14) levodopa-induced dyskinesias and a control group (n = 10) participated in the study...
July 6, 2018: Journal of Neurology
Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Takashi Tsuboi, Mizuki Ito, Naoki Atsuta, Hisayoshi Niwa, Toshiaki Taoka, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue
OBJECTIVE: We examined the anatomical involvement related to cognitive impairment in patients with multiple system atrophy (MSA). METHODS: We examined 30 patients with probable MSA and 15 healthy controls. All MSA patients were assessed by the Unified MSA-Rating scale and Addenbrooke's Cognitive Examination-Revised (ACE-R). We classified 15 MSA patients with ACE-R scores > 88 as having normal cognition (MSA-NC) and 15 with scores ≤ 88 as having cognitive impairment (MSA-CI)...
July 5, 2018: Journal of Neurology
Ulf Kallweit, Claudio L A Bassetti, Michael Oberholzer, Rolf Fronczek, Mathieu Béguin, Matthias Strub, Gert Jan Lammers
BACKGROUND: There are increasing data suggesting the involvement of the immune system in narcolepsy. The co-occurrence of narcolepsy with other autoimmune disorders (including multiple sclerosis, MS) is rare. PATIENTS AND METHODS: International multicenter sleep center survey and literature review on narcolepsy with (NC) and without (NwC) cataplexy. RESULTS: A total of 26 patients (pts), 6 in the survey and 20 in the literature were found...
July 4, 2018: Journal of Neurology
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