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Journal of Neurology

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https://www.readbyqxmd.com/read/28091723/changes-in-the-severity-and-subtype-of-guillain-barr%C3%A3-syndrome-admitted-to-a-specialist-neuromedical-icu-over-a-25%C3%A2-year-period
#1
C J Taylor, N P Hirsch, D M Kullmann, Robin S Howard
We report a retrospective review of 110 patients with acute Guillain-Barré syndrome (GBS) admitted to a specialised intensive care unit (ICU) in a tertiary referral centre over a 25 year period, the start of which coincided with the widespread introduction of plasma exchange (PE) and intravenous immunoglobulin (IVIG). The results were analysed by comparing 52 patients admitted in the first decade (1991-2000; Group 1) with 58 patients admitted between 2001-2014 (Group 2). Patients in both groups were comparable with respect to age and sex, and had a similar incidence and range of ICU complications...
January 16, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28083647/phenytoin-80%C3%A2-years-young-from-epilepsy-to-breast-cancer-a-remarkable-molecule-with-multiple-modes-of-action
#2
REVIEW
Jan M Keppel Hesselink, David J Kopsky
In 1908 phenytoin (5,5-diphenylhydantoin) was first synthesized as a barbiturate derivative in Germany by professor Heinrich Biltz (1865-1943) and subsequently resynthesized by an American chemist of the pharmaceutical company Parke-Davis in 1923 in Detroit. Screening phenytoin did not reveal comparable sedative side effects as barbiturates and, thus, Parke-Davis discarded this compound as a useful drug. In 1936, phenytoin's anticonvulsive properties were identified via a new animal model for convulsive disorders, developed by Putnam and Merritt, who also evaluated its clinical value in a number of patients in the period 1937-1940...
January 12, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28074268/cognitive-deficits-in-patients-with-a-chronic-vestibular-failure
#3
Pauline Popp, Melanie Wulff, Kathrin Finke, Maxine Rühl, Thomas Brandt, Marianne Dieterich
Behavioral studies in rodents and humans have demonstrated deficits of spatial memory and orientation in bilateral vestibular failure (BVF). Our aim was to explore the functional consequences of chronic vestibular failure on different cognitive domains including spatial as well as non-spatial cognitive abilities. Sixteen patients with a unilateral vestibular failure (UVF), 18 patients with a BVF, and 17 healthy controls (HC) participated in the study. To assess the cognitive domains of short-term memory, executive function, processing speed and visuospatial abilities the following tests were used: Theory of Visual Attention (TVA), TAP Alertness and Visual Scanning, the Stroop Color-Word, and the Corsi Block Tapping Test...
January 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28074267/reduced-serum-myostatin-concentrations-associated-with-genetic-muscle-disease-progression
#4
Peter M Burch, Oksana Pogoryelova, Joe Palandra, Richard Goldstein, Donald Bennett, Lori Fitz, Michela Guglieri, Chiara Marini Bettolo, Volker Straub, Teresinha Evangelista, Hendrik Neubert, Hanns Lochmüller, Carl Morris
Myostatin is a highly conserved protein secreted primarily from skeletal muscle that can potently suppress muscle growth. This ability to regulate skeletal muscle mass has sparked intense interest in the development of anti-myostatin therapies for a wide array of muscle disorders including sarcopenia, cachexia and genetic neuromuscular diseases. While a number of studies have examined the circulating myostatin concentrations in healthy and sarcopenic populations, very little data are available from inherited muscle disease patients...
January 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28070640/erratum-to-thrombectomy-for-ischemic-stroke-meta-analyses-of-recurrent-strokes-vasospasms-and-subarachnoid-hemorrhages
#5
Robert Emprechtinger, Brigitte Piso, Peter A Ringleb
No abstract text is available yet for this article.
January 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28062970/good-prognosis-of-postpartum-lower-limb-sensorimotor-deficit-a-combined-clinical-electrophysiological-and-radiological-follow-up
#6
A Richard, G Vellieux, S Abbou, J L Benifla, P Lozeron, N Kubis
Postpartum lower limb motor and/or sensory deficit is an uncommon obstetrical complication. We aimed to identify its incidence, etiology, and precipitating factors, as well as the neurological prognosis by retrospectively analyzing the successive neurological evaluations, electrophysiological, and MRI data from all the consecutive patients with postpartum motor and/or sensory deficits of the lower limbs referred from the Lariboisière Obstetrical Department to the Lariboisière Neurophysiology Department, from January 2012 to June 2016, as well as data concerning labor and morphological characteristics of mother and baby...
January 6, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28054131/global-and-regional-annual-brain-volume-loss-rates-in-physiological-aging
#7
Sven Schippling, Ann-Christin Ostwaldt, Per Suppa, Lothar Spies, Praveena Manogaran, Carola Gocke, Hans-Jürgen Huppertz, Roland Opfer
The objective is to estimate average global and regional percentage brain volume loss per year (BVL/year) of the physiologically ageing brain. Two independent, cross-sectional single scanner cohorts of healthy subjects were included. The first cohort (n = 248) was acquired at the Medical Prevention Center (MPCH) in Hamburg, Germany. The second cohort (n = 316) was taken from the Open Access Series of Imaging Studies (OASIS). Brain parenchyma (BP), grey matter (GM), white matter (WM), corpus callosum (CC), and thalamus volumes were calculated...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28054130/posterior-reversible-encephalopathy-syndrome
#8
REVIEW
Marlene Fischer, Erich Schmutzhard
The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness, confusion, seizures, and focal neurological deficits. In a majority of patients the clinical presentation includes elevated arterial blood pressure up to hypertensive emergencies. Neuroimaging, in particular magnetic resonance imaging, frequently shows a distinctive parieto-occipital pattern with a symmetric distribution of changes reflecting vasogenic edema...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28054129/the-relevance-of-gender-in-parkinson-s-disease-a-review
#9
REVIEW
Marina Picillo, Alessandra Nicoletti, Vincenza Fetoni, Barbara Garavaglia, Paolo Barone, Maria Teresa Pellecchia
Since the official and systematic inclusion of sex and gender in biomedical research, gender differences have been acknowledged as important determinants of both the susceptibility to develop neurodegenerative diseases in general population and the clinical and therapeutic management of neurodegenerative patients. In this review, we gathered the available evidence on gender differences in Parkinson's disease (PD) regarding clinical phenotype (including motor and non-motor symptoms), biomarkers, genetics and therapeutic management (including pharmacological and surgical treatment)...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28054128/folinic-acid-therapy-in-cerebral-folate-deficiency-marked-improvement-in-an-adult-patient
#10
LETTER
Ivan Karin, Ingo Borggraefe, Claudia B Catarino, Christoph Kuhm, Konstanze Hoertnagel, Saskia Biskup, Thomas Opladen, Nenad Blau, Florian Heinen, Thomas Klopstock
No abstract text is available yet for this article.
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28054127/rinsing-after-spinning-plasmapheresis-in-ebv-related-post-infectious-cerebellitis
#11
LETTER
Mauro Monforte, Giuseppe Reale, Carlo Masullo, Paolo Maria Rossini, Giorgio Tasca
No abstract text is available yet for this article.
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28054126/longitudinal-multi-modal-neuroimaging-in-opsoclonus-myoclonus-syndrome
#12
Sun-Young Oh, Rainer Boegle, Peter Zu Eulenburg, Matthias Ertl, Ji-Soo Kim, Marianne Dieterich
To investigate structural, metabolic, and functional connectivity changes in visual and oculomotor structures in a patient with paraneoplastic opsoclonus-myoclonus syndrome, serial resting-state functional and structural MRI, and FDG-PET data were collected during the acute stage and later on when the opsoclonus had resolved. In the acute stage, an FDG-PET scan demonstrated a substantially increased metabolism in structures around the deep cerebellar nuclei [e.g., fastigial nucleus (FN)] and a relatively reduced metabolism in the bilateral occipital lobes which normalized over 12 months...
January 4, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28050656/the-recommendations-of-a-consensus-panel-for-the-screening-diagnosis-and-treatment-of-neurogenic-orthostatic-hypotension-and-associated-supine-hypertension
#13
REVIEW
Christopher H Gibbons, Peter Schmidt, Italo Biaggioni, Camille Frazier-Mills, Roy Freeman, Stuart Isaacson, Beverly Karabin, Louis Kuritzky, Mark Lew, Phillip Low, Ali Mehdirad, Satish R Raj, Steven Vernino, Horacio Kaufmann
Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson's disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management. To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards 'best practices' when treating patients with nOH and associated supine hypertension...
January 3, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28039523/high-sensitivity-cardiac-troponin-i-and-nt-probnp-as-predictors-of-incident-dementia-and-alzheimer-s-disease-the-finrisk-study
#14
Juho Tynkkynen, Jussi A Hernesniemi, Tiina Laatikainen, Aki S Havulinna, Perttu Salo, Stefan Blankenberg, Tanja Zeller, Veikko Salomaa
Cardiac troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP) are known to associate with incident dementia. The purpose of our study was to examine whether high-sensitivity cardiac troponin I (hs-TnI) and NT-proBNP are associated with incident dementia and Alzheimer's disease (AD) independently of each other. Our study was a part of the national population-based health examination survey, FINRISK 1997, with a total sample of 7114 subjects, including 407 incident dementia cases and 319 AD cases during the follow-up time of 18 years...
December 30, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28039522/focal-task-specific-dystonia-a-review-and-update
#15
Christine M Stahl, Steven J Frucht
In this review, we summarize recent advances in understanding the etiology, risk factors and pathophysiology of focal task specific dystonia (FTSD), movement disorders characterized by abnormal motor activation during the performance of specific, repetitive actions. We focus on two common FTSD, musician's dystonia and writer's cramp. FTSD may pose a threat to the patient's livelihood, and improved therapeutic treatments are needed.
December 30, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28039521/echs1-deficiency-associated-paroxysmal-exercise-induced-dyskinesias-case-presentation-and-initial-benefit-of-intervention
#16
Abhimanyu Mahajan, Jules Constantinou, Christos Sidiropoulos
Paroxysmal exercise-induced dyskinesias (PED) are paroxysmal dyskinesias which manifest as dystonic movements brought on by sustained exercise. ECHS1 deficiency-induced EID was recently described by Olgiati et al. Our patient is an 8-year-old boy, who presented with intermittent episodes of stiffness and contractions affecting the legs which were always brought on by vigorous exertion. They began with curling of the toes and flexion, followed by stiffening of gait. These episodes were asymmetric, uncomfortable and often began in the left leg, often spreading to the right leg...
December 30, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28039520/natalizumab-associated-progressive-multifocal-leukoencephalopathy-successful-treatment-without-plasma-exchange-and-its-associated-risks
#17
LETTER
Eimer Maloney, Anna Molloy, Mariam Al Hussona, Luke O'Donnell, Ronan Killeen, Christopher McGuigan
No abstract text is available yet for this article.
December 30, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28028626/migraine-causes-retinal-and-choroidal-structural-changes-evaluation-with-ocular-coherence-tomography
#18
Ester Reggio, Clara G Chisari, Giulia Ferrigno, Francesco Patti, Giulia Donzuso, Giorgia Sciacca, Teresio Avitabile, Salvatore Faro, Mario Zappia
Few studies have evaluated whether the retina is involved in migraine through the evaluation of retinal nerve fiber layer (RNFL) examined with ocular coherence tomography (OCT) with conflicting results. Aim of this case-control study is to evaluate the retina and the choroid in migraine. Patients having migraine with aura (MwA) or without aura (MoA) and chronic migraine (CM) were evaluated. Age- and sex-matched normal subjects were selected as healthy controls (HC). Patients and HC were examined with OCT. RNFL, ganglion cell layer (GCL), foveal thickness (FT), choroidal thickness (CT) and total macular volume (TMV) were calculated for right eyes (RE) and left eyes (LE)...
December 27, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28028625/an-unsuspected-cause-of-hypnic-like-headache
#19
LETTER
Mariana Fonseca, Pedro Teotónio, Ana Catarina Fonseca
No abstract text is available yet for this article.
December 27, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28028624/intravenous-thrombolysis-of-stroke-in-early-pregnancy-a-case-report-and-review-of-the-literature
#20
LETTER
Alice Reining-Festa, Daniela Földy, Margarethe Coulibaly-Wimmer, Lisbeth Eischer, Maria Heger, Elisabeth Fertl
No abstract text is available yet for this article.
December 27, 2016: Journal of Neurology
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