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Journal of Neurology

Annette Baumgartner, Sebastian Rauer, Tilman Hottenrott, Frank Leypoldt, Friederike Ufer, Harald Hegen, Harald Prüss, Jan Lewerenz, Florian Deisenhammer, Oliver Stich
BACKGROUND: Since the detection of autoantibodies against neuronal surface antigens, autoimmune encephalitis (AE) has been more frequently diagnosed, especially in patients with symptoms typical of limbic encephalitis, such as seizures, short-term memory deficits, or psychosis. However, the clinical spectrum of AE may be much wider, making correct clinical diagnosis difficult. METHODS: We retrospectively analysed symptoms and admission diagnoses at first clinical presentation in 50 AE patients...
November 12, 2018: Journal of Neurology
Sun-Uk Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim
No abstract text is available yet for this article.
November 12, 2018: Journal of Neurology
Wenchao Cheng, Yuhan Wang, Yajun Lian, Jing Zhang, Yake Zheng, Yiying Hu, Yuan Chen, Shouyi Wu, Zhi Huang, Yinping Shi
BACKGROUND: Cervicocerebral artery dissection (CAD) is a major cause of ischemic stroke in young adults. There are many existing studies on determinants for CAD; however, they are still not totally defined. We conduct the study to further investigate the determinants for CAD based on ischemic stroke patients. METHODS: 81 ischemic stroke patients with CAD were enrolled in the CAD stroke group and 84 ischemic stroke patients without CAD were enrolled in the non-CAD stroke group...
November 12, 2018: Journal of Neurology
María Soledad Sáez, Juan Ignacio Rojas, María Victoria Lorenzón, Francisco Sánchez, Liliana Patrucco, Jimena Míguez, Carolina Azcona, Patricia Sorroche, Edgardo Cristiano
BACKGROUND: The objective was to evaluate the precision of kappa and lambda free light chains (KFLC and LFLC) in CSF for the diagnosis of multiple sclerosis (MS) and prognosis of clinically isolated syndrome (CIS). METHODS: CSF and serum samples from CIS, MS and other neurological non-MS disease were collected between 2015 and 2017. FLC concentrations were measured using immunoassay Freelite™. Results were correlated with the patients' diagnoses and ROC curve analysis was used to determine accuracy...
November 1, 2018: Journal of Neurology
Maria Stefania De Simone, Roberta Perri, Lucia Fadda, Carlo Caltagirone, Giovanni Augusto Carlesimo
The research of reliable procedures for predicting cognitive decline or stability in persons with amnestic mild cognitive impairment (a-MCI) is a major goal for the early identification of subjects in the prodromal stages of dementia. The aim of this study was to evaluate whether different memory performances on two procedures commonly used for the neuropsychological assessment of episodic memory (i.e., free recall and recognition) might be a key in predicting a-MCI patients' subsequent progression to Alzheimer's disease (AD)...
November 1, 2018: Journal of Neurology
Rodolfo Tonin, Serena Catarzi, Anna Caciotti, Elena Procopio, Carla Marini, Renzo Guerrini, Amelia Morrone
BACKGROUND: Patients with Gaucher Disease (GD) exhibit three phenotypes, including type 1 (non-neuronopathic), type 2 (acute neuronopathic), and type 3 (subacute neuronopathic). AIM: Identifying which GBA changes represent benign polymorphisms and which may result in disease-causing mutations is essential for diagnosis and genotype/phenotype correlations but is often challenging. RESULTS: Here, we describe a patient with type 3 GD, presenting with drug-resistant epilepsy, who bears a set of GBA polymorphic variants including the novel c...
October 31, 2018: Journal of Neurology
James A Robertson, Emma C Tallantyre
No abstract text is available yet for this article.
October 31, 2018: Journal of Neurology
Alberto Romagnolo, Maurizio Zibetti, Aristide Merola, Daniela Canova, Marianna Sarchioto, Elisa Montanaro, Carlo Alberto Artusi, Fabrizio Vallelonga, Simona Maule, Leonardo Lopiano
BACKGROUND: Falls represent one of the main complications of Parkinson's disease (PD), significantly lowering quality of life. Cardiovascular autonomic neuropathy (cAN) is one of the key contributing factors to PD-associated falls. However, a direct quantification of its impact on the risk of falling in PD is still lacking. In this 12-month prospective study, we sought to evaluate the association between cAN and falls. METHODS: Fifty consecutive patients were evaluated with a standardized battery of autonomic testing, Unified Parkinson's Disease Rating Scale, push and release (P&R) test, timed up and go test, freezing of gait (FOG) questionnaire, Montreal cognitive assessment (MoCA)...
October 31, 2018: Journal of Neurology
Emma C Argaet, Allison S Young, Andrew P Bradshaw, Miriam S Welgampola
No abstract text is available yet for this article.
October 30, 2018: Journal of Neurology
Andrzej Grzybowski, Marta Pugaczewska, Aleksandra Pięta, Igor Stolarek
No abstract text is available yet for this article.
October 30, 2018: Journal of Neurology
Ee Wei Lim, Dag Aarsland, Dominic Ffytche, Raquel Natalia Taddei, Daniel J van Wamelen, Yi-Min Wan, Eng King Tan, Kallol Ray Chaudhuri
Parkinson's disease (PD) is the second commonest neurodegenerative disorder in the world with a rising prevalence. The pathophysiology is multifactorial but aggregation of misfolded α-synuclein is considered to be a key underpinning mechanism. Amyloid-β (Aβ) and tau deposition are also comorbid associations and especially Aβ deposition is associated with cognitive decline in PD. Some existing evidence suggests that low cerebrospinal fluid (CSF) Aβ42 is predictive of future cognitive impairment in PD. Recent studies also show that CSF Aβ is associated with the postural instability and gait difficulties (PIGD) or the newly proposed cholinergic subtype of PD, a possible risk factor for cognitive decline in PD...
October 30, 2018: Journal of Neurology
Mathias Barra, Angela S Labberton, Kashif W Faiz, Jonas C Lindstrøm, Ole Morten Rønning, Joe Viana, Fredrik A Dahl, Kim Rand
INTRODUCTION: While there is a general agreement that stroke incidence among the elderly is declining in the developed world, there is a concern that it may be increasing among the young. The present study investigates this issue for the Norwegian population for the years 2010-2015. Cerebrovascular accidents (CVAs) for patients younger than 55 years were identified through the Norwegian Patient Registry and the Norwegian Cause-of-death Registry. METHODS: Negative binomial regression modelling was used to estimate temporal trends in the CVA incidence rates for the young, aged 15-54, with 10-year sub-intervals, and for children below the age of 18...
October 30, 2018: Journal of Neurology
Gisa Ellrichmann, Jan Bolz, Maren Peschke, Alexander Duscha, Kerstin Hellwig, De-Hyung Lee, Ralf A Linker, Ralf Gold, Aiden Haghikia
BACKGROUND: With ocrelizumab another drug is available for the treatment of multiple sclerosis (MS). Little is known on the long-term use of ocrelizumab on immune cell subsets, and no surrogate markers are available. Rituximab (RTX) has been in off-label use for the treatment of MS, neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) for > 10 years. OBJECTIVE: We evaluated the long-term depletion and repopulation rate of peripheral CD19+ B-cells as a potential surrogate for the clinical outcome, and whether it may serve for dosage and time-to-infusion decision making...
October 30, 2018: Journal of Neurology
Gerd Fabian Volk, Anika Steinerstauch, Annegret Lorenz, Luise Modersohn, Oliver Mothes, Joachim Denzler, Carsten M Klingner, Farsin Hamzei, Orlando Guntinas-Lichius
Although central facial paresis (CFP) is a major symptom of stroke, there is a lack of studies on the motor and non-motor disabilities in stroke patients. A prospective cohort study was performed at admission for inpatient rehabilitation and discharge of post-stroke phase of 112 patients (44% female, median age: 64 years, median Barthel index: 70) with CFP. Motor function was evaluated using House-Brackmann grading, Sunnybrook grading and Stennert Index. Automated action unit (AU) analysis was performed to analyze mimic function in detail...
October 26, 2018: Journal of Neurology
Hayley C Gorton, Roger T Webb, W Owen Pickrell, Matthew J Carr, Darren M Ashcroft
OBJECTIVE: To estimate the risk of self-harm in people with epilepsy and identify factors which influence this risk. METHODS: We identified people with incident epilepsy in the Clinical Practice Research Datalink, linked to hospitalization and mortality data, in England (01/01/1998-03/31/2014). In Phase 1, we estimated risk of self-harm among people with epilepsy, versus those without, in a matched cohort study using a stratified Cox proportional hazards model. In Phase 2, we delineated a nested case-control study from the incident epilepsy cohort...
October 24, 2018: Journal of Neurology
Christian Lunetta, Andrea Lizio, Lucio Tremolizzo, Massimiliano Ruscica, Chiara Macchi, Nilo Riva, Patrick Weydt, Ettore Corradi, Paolo Magni, Valeria Sansone
INTRODUCTION: The progression of amyotrophic lateral sclerosis (ALS) leads to a decline of the nutritional status that represents an independent prognostic factor for survival. Recent studies recognize the muscle tissue as an endocrine organ able to release several molecules, called myokines. Among them, irisin seems to be involved in the regulation of metabolism, body weight and development and function of the nervous system. OBJECTIVES: (1) To evaluate irisin serum levels in patients with ALS, with comparison to healthy subjects; (2) to assess the possible association of circulating irisin levels of ALS patients with the metabolic status, clinical and biochemical features...
October 22, 2018: Journal of Neurology
Barbara Casolla, François Caparros, Charlotte Cordonnier, Stéphanie Bombois, Hilde Hénon, Régis Bordet, Francesco Orzi, Didier Leys
BACKGROUND: Cognitive impairment is frequent after stroke, and several studies have suggested that biological and imaging characteristics present before stroke are associated with the development of post-stroke cognitive impairment. OBJECTIVE: The aim of our study was to systematically review biological and imaging predictors of cognitive impairment after stroke. METHOD: Studies were identified from bibliographic databases and reference lists, and were included if conducted in patients with acute stroke, with at least 30 patients, and a follow-up of at least 3 months...
October 22, 2018: Journal of Neurology
Jae-Hwan Choi, Eun Hye Oh, Min-Gyu Park, Seung Kug Baik, Han-Jin Cho, Seo Young Choi, Tae-Hong Lee, Ji Soo Kim, Kwang-Dong Choi
The aim of this study was to determine the frequency, clinical and radiological features, and efficacy of clinical evaluation and perfusion-weighted imaging (PWI) for the prediction of final stroke in patients with DWI/MRI-negative posterior circulation stroke (PCS) presenting acute dizziness/vertigo. From our comprehensive prospective stroke registry of acute ischemic stroke during a 7-year period, we identified 1846 consecutive patients with PCS, 850 of whom presented with acute dizziness/vertigo. Of these 850 patients, initial DWI-MRI was negative in 35 (4...
October 19, 2018: Journal of Neurology
Seunghee Na, Eek-Sung Lee, Jong Dae Lee, Ki-Bum Sung, Tae-Kyeong Lee
No abstract text is available yet for this article.
October 19, 2018: Journal of Neurology
Stefan Braune, Sarah Grimm, Philip van Hövell, Ulrich Freudensprung, Fabio Pellegrini, Robert Hyde, Arnfin Bergmann
BACKGROUND: Comparative effectiveness (CE) research allows real-world treatment comparisons using outcome measurements important to physicians/patients. This German NeuroTransData registry-based analysis compared delayed-release dimethyl fumarate (DMF) effectiveness with interferons (IFN), glatiramer acetate (GA), teriflunomide (TERI), or fingolimod (FTY) in patients with relapsing-remitting multiple sclerosis (RRMS) using propensity score matching (PSM). METHODS: Data from registry patients aged ≥ 18 years with RRMS, ≥ 1 relapse, and Expanded Disability Status Scale (EDSS) assessment(s) after index therapy initiation underwent 1:1 PSM to match DMF with comparator populations baseline characteristics...
October 16, 2018: Journal of Neurology
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