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Journal of the National Cancer Institute

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https://www.readbyqxmd.com/read/28525914/cigarette-filter-ventilation-and-its-relationship-to-increasing-rates-of-lung-adenocarcinoma
#1
Min-Ae Song, Neal L Benowitz, Micah Berman, Theodore M Brasky, K Michael Cummings, Dorothy K Hatsukami, Catalin Marian, Richard O'Connor, Vaughan W Rees, Casper Woroszylo, Peter G Shields
The 2014 Surgeon General's Report on smoking and health concluded that changing cigarette designs have caused an increase in lung adenocarcinomas, implicating cigarette filter ventilation that lowers smoking machine tar yields. The Food and Drug Administration (FDA) now has the authority to regulate cigarette design if doing so would improve public health. To support a potential regulatory action, two weight-of-evidence reviews were applied for causally relating filter ventilation to lung adenocarcinoma. Published scientific literature (3284 citations) and internal tobacco company documents contributed to causation analysis evidence blocks and the identification of research gaps...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28525913/should-the-fda-ban-cigarette-filter-ventilation
#2
Jonathan M Samet, Lilit Aladadyan
No abstract text is available yet for this article.
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521333/drugging-the-cancers-addicted-to-dna-repair
#3
Jac A Nickoloff, Dennie Jones, Suk-Hee Lee, Elizabeth A Williamson, Robert Hromas
Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2). It now appears that a clinically significant fraction of cancers have acquired DNA repair defects. DNA repair pathways operate in related networks, and cancers arising from loss of one DNA repair component typically become addicted to other repair pathways to survive and proliferate. Drug inhibition of the rescue repair pathway prevents the repair-deficient cancer cell from replicating, causing apoptosis (termed synthetic lethality)...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28419299/pregnancy-and-labor-complications-in-female-survivors-of-childhood-cancer-the-british-childhood-cancer-survivor-study
#4
Raoul C Reulen, Chloe J Bright, David L Winter, Miranda M Fidler, Kwok Wong, Joyeeta Guha, Julie S Kelly, Clare Frobisher, Angela B Edgar, Roderick Skinner, W Hamish B Wallace, Mike M Hawkins
Background: Female survivors of childhood cancer treated with abdominal radiotherapy who manage to conceive are at risk of delivering premature and low-birthweight offspring, but little is known about whether abdominal radiotherapy may also be associated with additional complications during pregnancy and labor. We investigated the risk of developing pregnancy and labor complications among female survivors of childhood cancer in the British Childhood Cancer Survivor Study (BCCSS). Methods: Pregnancy and labor complications were identified by linking the BCCSS cohort (n = 17 980) to the Hospital Episode Statistics (HES) for England...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521366/post-traumatic-stress-as-the-primary-cause-for-cognitive-decline-not-the-whole-story-and-perhaps-no-story-at-all
#5
Sanne B Schagen, Jeffrey S Wefel
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521365/cognitive-dysfunction-in-cancer-patients-likely-not-all-due-to-chemotherapy
#6
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521364/chemotherapy-and-post-traumatic-stress-in-the-causation-of-cognitive-dysfunction-in-breast-cancer-patients
#7
Kerstin Hermelink, Markus Bühner, Philipp Sckopke, Franziska Neufeld, Judith Kaste, Varinka Voigt, Karin Münzel, Rachel Wuerstlein, Nina Ditsch, Karin Hellerhoff, Dorothea Rjosk-Dendorfer, Michael Braun, Franz Edler von Koch, Kristin Härtl, Stephan Hasmüller, Ingo Bauerfeind, Gerlinde Debus, Peter Herschbach, Sven Mahner, Nadia Harbeck
Background: Cancer-related cognitive dysfunction has mostly been attributed to chemotherapy; this explanation, however, fails to account for cognitive dysfunction observed in chemotherapy-naïve patients. In a controlled, longitudinal, multisite study, we tested the hypothesis that cognitive function in breast cancer patients is affected by cancer-related post-traumatic stress. Methods: Newly diagnosed breast cancer patients and healthy control subjects, age 65 or younger, underwent three assessments within one year, including paper-and-pencil and computerized neuropsychological tests, clinical diagnostics of post-traumatic stress disorder (PTSD), and self-reported cognitive function...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521363/a-cisplatin-derivative-tetra-pt-bpy-as-an-oncotherapeutic-agent-for-targeting-alt-cancer
#8
Xiao-Hui Zheng, Xin Nie, Yiming Fang, Zepeng Zhang, Yingnan Xiao, Zongwan Mao, Haiying Liu, Jian Ren, Feng Wang, Lixin Xia, Junjiu Huang, Yong Zhao
Background: In approximately 15% of human cancers, telomere length is maintained independently of telomerase by the homologous recombination (HR)-mediated alternative lengthening of telomeres (ALT) pathway. Whether the ALT pathway can be exploited for therapeutic treatment remains unknown. The purpose of this study is to develop oncotherapeutic agent to target ALT cancers. Methods: Surface plasmon resonance assay, antibody to G-quadruplex, and fluorescence in situ hybridization (FISH) were used to discover Tetra-Pt(bpy), a cisplatin derivative that specifically targets telomeric G-quadruplex...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521362/association-of-common-genetic-variants-with-contralateral-breast-cancer-risk-in-the-wecare-study
#9
Mark E Robson, Anne S Reiner, Jennifer D Brooks, Patrick J Concannon, Esther M John, Lene Mellemkjaer, Leslie Bernstein, Kathleen E Malone, Julia A Knight, Charles F Lynch, Meghan Woods, Xiaolin Liang, Robert W Haile, David J Duggan, Roy E Shore, Susan A Smith, Duncan C Thomas, Daniel O Stram, Jonine L Bernstein
Background: Women with unilateral breast cancer (UBC) are at risk of developing a subsequent contralateral breast cancer (CBC). Common variants are associated with breast cancer risk. Whether these influence CBC risk is unknown. Methods: Participants were breast cancer cases from the population-based Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study. Sixty-seven established breast cancer risk loci were genotyped directly or by imputation in 1459 case subjects with CBC and 2126 UBC control subjects...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28521361/hypofractionated-radiotherapy-for-patients-with-early-stage-glottic-cancer-patterns-of-care-and-survival
#10
Trevor J Bledsoe, Henry S Park, John M Stahl, Wendell G Yarbrough, Barbara A Burtness, Roy H Decker, Zain A Husain
Background: Radiotherapy alone is often used to treat early-stage glottic cancer (ESGC); however, the optimal radiation treatment schedule remains unknown. The National Comprehensive Cancer Network (NCCN) guidelines recommend both hypofractionated radiotherapy (HFX) and conventionally fractionated radiotherapy (CFX). We compared overall survival (OS) and treatment patterns among patients treated with HFX vs CFX for ESGC using a large national database. Methods: We identified patients diagnosed with stage I-II (cT1-2N0M0) glottic cancer from 2004 to 2013 within the National Cancer Data Base who were treated with either HFX (2...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28423401/response
#11
Shailender Bhatia, Barry E Storer, Paul Nghiem
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28423400/re-adjuvant-radiation-therapy-and-chemotherapy-in-merkel-cell-carcinoma-survival-analyses-of-6908-cases-from-the-national-cancer-data-base
#12
John A Vargo, Erica R Ghareeb, Goundappa K Balasubramani, Sushil Beriwal
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28423399/restarting-adjuvant-hormone-therapy-improves-breast-cancer-outcomes
#13
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28423398/treatment-restarting-after-discontinuation-of-adjuvant-hormone-therapy-in-breast-cancer-patients
#14
Wei He, Karin E Smedby, Fang Fang, Henrik Olsson, Sara Margolin, Per Hall, Kamila Czene
Background: Over half of breast cancer patients discontinue their adjuvant hormone therapy, permanently or temporarily. We aimed to identify predictors of treatment restarting after discontinuation of adjuvant hormone therapy and to test the hypothesis that treatment restarting is associated with better breast cancer outcomes. Methods: We conducted a population-based cohort study by linking data from the Stockholm-Gotland Breast Cancer Register, the Swedish Prescribed Drug Register, and a self-reported questionnaire...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376199/refining-risk-assessment-in-women-with-benign-breast-disease-an-ongoing-dilemma
#15
Stuart J Schnitt, Monica Morrow, Nadine M Tung
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376198/breast-cancer-risk-and-progressive-histology-in-serial-benign-biopsies
#16
Daniel W Visscher, Ryan D Frank, Jodi M Carter, Robert A Vierkant, Stacey J Winham, Ethan P Heinzen, Brendan T Broderick, Lori A Denison, Teresa M Allers, Joanne L Johnson, Marlene H Frost, Lynn C Hartmann, Amy C Degnim, Derek C Radisky
Background: More than 1 million women per year in the United States with benign breast biopsies are known to be at elevated risk for breast cancer (BC), with risk stratified on histologic categories of epithelial proliferation. Here we assessed women who had serial benign biopsies over time and how changes in the histologic classification affected BC risk. Methods: In the Mayo Clinic Benign Breast Disease Cohort of 13 466 women, 1414 women had multiple metachronous benign biopsies (10...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28423408/the-patient-knows-best-incorporating-patient-reported-outcomes-into-routine-clinical-care
#17
Ryan Nipp, Jennifer Temel
No abstract text is available yet for this article.
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28423407/randomized-trial-comparing-a-web-mediated-follow-up-with-routine-surveillance-in-lung-cancer-patients
#18
RANDOMIZED CONTROLLED TRIAL
Fabrice Denis, Claire Lethrosne, Nicolas Pourel, Olivier Molinier, Yoann Pointreau, Julien Domont, Hugues Bourgeois, Hélène Senellart, Pierre Trémolières, Thibaut Lizée, Jaafar Bennouna, Thierry Urban, Claude El Khouri, Alexandre Charron, Anne-Lise Septans, Magali Balavoine, Sébastien Landry, Philippe Solal-Céligny, Christophe Letellier
Background: The use of web-based monitoring for lung cancer patients is growing in interest because of promising recent results suggesting improvement in cancer and resource utilization outcomes. It remains an open question whether the overall survival (OS) in these patients could be improved by using a web-mediated follow-up rather than classical scheduled follow-up and imaging. Methods: Advanced-stage lung cancer patients without evidence of disease progression after or during initial treatment were randomly assigned in a multicenter phase III trial to compare a web-mediated follow-up algorithm (experimental arm), based on weekly self-scored patient symptoms, with routine follow-up with CT scans scheduled every three to six months according to the disease stage (control arm)...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376154/annual-report-to-the-nation-on-the-status-of-cancer-1975-2014-featuring-survival
#19
Ahmedin Jemal, Elizabeth M Ward, Christopher J Johnson, Kathleen A Cronin, Jiemin Ma, Blythe Ryerson, Angela Mariotto, Andrew J Lake, Reda Wilson, Recinda L Sherman, Robert N Anderson, S Jane Henley, Betsy A Kohler, Lynne Penberthy, Eric J Feuer, Hannah K Weir
Background: The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States. This Annual Report highlights survival rates. Data were from the CDC- and NCI-funded population-based cancer registry programs and compiled by NAACCR. Trends in age-standardized incidence and death rates for all cancers combined and for the leading cancer types by sex were estimated by joinpoint analysis and expressed as annual percent change...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376153/evidence-for-a-mesothelial-origin-of-body-cavity-effusion-lymphomas
#20
David Sanchez-Martin, Thomas S Uldrick, Hyeongil Kwak, Hidetaka Ohnuki, Mark N Polizzotto, Christina M Annunziata, Mark Raffeld, Kathleen M Wyvill, Karen Aleman, Victoria Wang, Vickie A Marshall, Denise Whitby, Robert Yarchoan, Giovanna Tosato
Background: Primary effusion lymphoma (PEL) is a Kaposi's sarcoma herpes virus (KSHV)-induced lymphoma that typically arises in body cavities of HIV-infected patients. PEL cells are often co-infected with Epstein-Barr virus (EBV). "PEL-like" lymphoma is a KSHV-unrelated lymphoma that arises in body cavities of HIV-negative patients. "PEL-like" lymphoma is sometimes EBV positive. The derivation of PEL/"PEL-like" cells is unclear. Methods: Mesothelial cells were cultured from body cavity effusions of 23 patients...
September 1, 2017: Journal of the National Cancer Institute
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