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Journal of the National Cancer Institute

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https://www.readbyqxmd.com/read/30203099/claudin18-2-specific-chimeric-antigen-receptor-engineered-t-cells-for-the-treatment-of-gastric-cancer
#1
Hua Jiang, Zhimin Shi, Peng Wang, Cong Wang, Linlin Yang, Guoxiu Du, Honghong Zhang, Bizhi Shi, Jie Jia, Qixiang Li, Huamao Wang, Zonghai Li
Background: Claudin18.2 (CLDN18.2), a gastric-specific membrane protein, has been regarded as a potential therapeutic target for gastric cancer and other cancer types. The aim of our study was to elucidate whether chimeric antigen receptor T (CAR T) cells redirected to CLDN18.2 have the potential to be used in the treatment of this deadly disease. Methods: CLDN18.2-specific humanized antibodies were developed using hybridoma and humanization technology. CLDN18.2-specific CAR T cells were prepared by lentiviral vector transduction...
September 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30202928/omega-3-fatty-acids-and-prostate-cancer-g-protein-coupled-receptors-to-the-rescue
#2
Kathryn E Meier
No abstract text is available yet for this article.
September 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30202902/role-of-host-gpr120-in-mediating-dietary-omega-3-fatty-acid-inhibition-of-prostate-cancer
#3
Pei Liang, Susanne M Henning, Johnny Guan, Tristan Grogan, David Elashoff, Jerrold M Olefsky, Pinchas Cohen, William J Aronson
Background: GPR120, a G protein-coupled receptor for long-chain polyunsaturated fatty acids (FAs), mediates the anti-inflammatory effects of omega-3 (ω-3) FAs. We investigated whether host or tumor GPR120 plays a role in the anti-prostate cancer effects of ω-3 FAs. Methods: MycCap prostate cancer allografts were grown in immunocompetent wild-type (WT) and GPR120 knockout (KO) mice fed ω-3 (fish oil) or ω-6 (corn oil) diets. Immune cell infiltration was quantified by flow cytometry, and gene expression of immune cell markers in isolated tumor-associated macrophages (TAMs) was quantified by quantitative real-time polymerase chain reaction...
September 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30169727/erratum-to-p16-as-a-prognostic-biomarker-for-nonoropharyngeal-squamous-cell-cancers-avatar-or-mirage
#4
(no author information available yet)
No abstract text is available yet for this article.
August 30, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30165635/corrigendum-to-radiation-exposure-from-pediatric-ct-scans-and-subsequent-cancer-risk-in-the-netherlands-by-johanna-m-meulepas-et-al
#5
(no author information available yet)
No abstract text is available yet for this article.
August 27, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30137376/a-plasma-derived-protein-metabolite-multiplexed-panel-for-early-stage-pancreatic-cancer
#6
Johannes F Fahrmann, Leonidas E Bantis, Michela Capello, Ghislaine Scelo, Jennifer B Dennison, Nikul Patel, Eunice Murage, Jody Vykoukal, Deepali L Kundnani, Lenka Foretova, Eleonora Fabianova, Ivana Holcatova, Vladimir Janout, Ziding Feng, Michele Yip-Schneider, Jianjun Zhang, Randall Brand, Ayumu Taguchi, Anirban Maitra, Paul Brennan, C Max Schmidt, Samir Hanash
Background: We applied a training and testing approach to develop and validate a plasma metabolite panel for the detection of early-stage pancreatic ductal adenocarcinoma (PDAC) alone and in combination with a previously validated protein panel for early-stage PDAC. Methods: A comprehensive metabolomics platform was initially applied to plasmas collected from 20 PDAC cases and 80 controls. Candidate markers were filtered based on a second independent cohort that included nine invasive intraductal papillary mucinous neoplasm cases and 51 benign pancreatic cysts...
August 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30099541/triple-negative-breast-cancer-risk-genes-identified-by-multigene-hereditary-cancer-panel-testing
#7
Hermela Shimelis, Holly LaDuca, Chunling Hu, Steven N Hart, Jie Na, Abigail Thomas, Margaret Akinhanmi, Raymond M Moore, Hiltrud Brauch, Angela Cox, Diana M Eccles, Amanda Ewart-Toland, Peter A Fasching, Florentia Fostira, Judy Garber, Andrew K Godwin, Irene Konstantopoulou, Heli Nevanlinna, Priyanka Sharma, Drakoulis Yannoukakos, Song Yao, Bing-Jian Feng, Brigette Tippin Davis, Jenna Lilyquist, Tina Pesaran, David E Goldgar, Eric C Polley, Jill S Dolinsky, Fergus J Couch
Background: Germline genetic testing with hereditary cancer gene panels can identify women at increased risk of breast cancer. However, those at increased risk of triple-negative (estrogen receptor-negative, progesterone receptor-negative, human epidermal growth factor receptor-negative) breast cancer (TNBC) cannot be identified because predisposition genes for TNBC, other than BRCA1, have not been established. The aim of this study was to define the cancer panel genes associated with increased risk of TNBC...
August 7, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30085269/overview-of-oncology-and-hematology-drug-approvals-at-us-food-and-drug-administration-between-2008-and-2016
#8
Jiaxi Zhou, Jonathon Vallejo, Paul Kluetz, Richard Pazdur, Tamy Kim, Patricia Keegan, Ann Farrell, Julia A Beaver, Rajeshwari Sridhara
Background: We previously conducted an overview of oncology products reviewed by the Office of Oncology Drug Products in the Center for Drug Evaluation and Research at the US Food and Drug Administration for marketing approval and the regulatory actions taken during July 2005 to December 2007. There is a need to understand if the changes in the laws, regulations, and the organization that occurred after 2007 had any impact on the regulatory drug approvals. We present a detailed overview of hematology and oncology products reviewed by Office of Oncology Drug Products and Office of Hematology and Oncology Drug Products...
August 4, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30085213/determinants-and-consequences-of-financial-hardship-among-adult-survivors-of-childhood-cancer-a-report-from-the-st-jude-lifetime-cohort-study
#9
I-Chan Huang, Nickhill Bhakta, Tara M Brinkman, James L Klosky, Kevin R Krull, DeoKumar Srivastava, Melissa M Hudson, Leslie L Robison
Background: Financial hardship among survivors of pediatric cancer has been understudied. We investigated determinants and consequences of financial hardship among adult survivors of childhood cancer. Methods: Financial hardship, determinants, and consequences were examined in 2811 long-term survivors (mean age at evaluation = 31.8 years, years postdiagnosis = 23.6) through the baseline survey and clinical evaluation. Financial hardship was measured by material, psychological, and coping/behavioral domains...
August 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30085202/the-long-shadow-of-childhood-cancer-lasting-risk-of-medical-financial-hardship
#10
Zhiyuan Zheng, K Robin Yabroff
No abstract text is available yet for this article.
August 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30053118/resource-utilization-and-costs-in-adolescents-treated-for-cancer-in-pediatric-vs-adult-institutions
#11
Paul C Nathan, Karen E Bremner, Ning Liu, Sumit Gupta, Mark L Greenberg, Mary L McBride, Murray D Krahn, Claire de Oliveira
Background: Adolescents with cancer can receive care in pediatric or adult institutions. Survival often differs by locus, but little is known about relative health care utilization and costs. We estimated these in a population-based cohort of adolescents. Methods: All Ontario adolescents (15.0-17.9 years) diagnosed with cancer between 1995 and 2010 were identified from provincial cancer registries. We compared health care resource utilization (hospitalizations, emergency department visits, same-day surgeries, outpatient chemotherapy, radiation, diagnostic/laboratory tests, physician services, home care) and costs (2012 Canadian dollars) during four discrete care phases-prediagnosis (60 days), initial (360 days), continuing (variable), and terminal (360 days)-between adolescents treated in pediatric vs adult institutions, for the whole cohort and within seven diagnostic categories...
July 19, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30053066/does-treatment-setting-matter-evaluating-resource-utilization-for-adolescents-treated-in-pediatric-vs-adult-cancer-institutions
#12
Helen M Parsons, Lori Muffly, Elysia M Alvarez, Theresa H M Keegan
No abstract text is available yet for this article.
July 19, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30032196/long-term-pooled-safety-analysis-of-palbociclib-in-combination-with-endocrine-therapy-for-hr-her2-advanced-breast-cancer
#13
Véronique Diéras, Hope S Rugo, Patrick Schnell, Karen Gelmon, Massimo Cristofanilli, Sherene Loi, Marco Colleoni, Dongrui R Lu, Ave Mori, Eric Gauthier, Cynthia Huang Bartlett, Dennis J Slamon, Nicholas C Turner, Richard S Finn
Background: Palbociclib administered with endocrine therapy was tolerable when the overall incidence of toxicities was assessed separately for three PALOMA studies. This study analyzed pooled, longer-term PALOMA safety data longitudinally. Methods: Data were pooled from three randomized phase II and III studies (ClinicalTrials.gov: NCT00721409, NCT01740427, NCT01942135) of hormone receptor-positive/human epidermal growth factor receptor 2‒negative advanced breast cancer patients...
July 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30020493/radiation-exposure-from-pediatric-ct-scans-and-subsequent-cancer-risk-in-the-netherlands
#14
Johanna M Meulepas, Cécile M Ronckers, Anne M J B Smets, Rutger A J Nievelstein, Patrycja Gradowska, Choonsik Lee, Andreas Jahnen, Marcel van Straten, Marie-Claire Y de Wit, Bernard Zonnenberg, Willemijn M Klein, Johannes H Merks, Otto Visser, Flora E van Leeuwen, Michael Hauptmann
Background: Computed tomography (CT), a strong diagnostic tool, delivers higher radiation doses than most imaging modalities. As CT use has increased rapidly, radiation protection is important, particularly among children. We evaluate leukemia and brain tumor risk following exposure to low-dose ionizing radiation from CT scans in childhood. Methods: For a nationwide retrospective cohort of 168 394 children who received one or more CT scans in a Dutch hospital between 1979 and 2012 who were younger than age 18 years, we obtained cancer incidence, vital status, and confounder information by record linkage with external registries...
July 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30016506/corrigendum-to-cost-and-complications-of-local-therapies-for-early-stage-breast-cancer
#15
(no author information available yet)
No abstract text is available yet for this article.
July 16, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30016454/circulating-27-hydroxycholesterol-and-breast-cancer-risk-results-from-the-epic-heidelberg-cohort
#16
Da-Lin Lu, Charlotte Le Cornet, Disorn Sookthai, Theron S Johnson, Rudolf Kaaks, Renée T Fortner
Background: 27-hydroxycholesterol (27HC) was the first identified endogenous selective estrogen receptor modulator (SERM); 27HC promoted growth and metastasis in experimental models of estrogen receptor-positive mammary cancer. There are no data on prediagnosis circulating 27HC and breast cancer risk in women. Methods: We conducted a nested case-control study in the well-characterized Heidelberg, Germany, cohort of the European Investigation into Cancer and Nutrition (EPIC) including 530 incident invasive breast cancer cases, each matched to up to two control participants (n = 1036)...
July 16, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29986068/corrigendum-to-novel-role-of-fbxw7-circular-rna-in-repressing-glioma-tumorigenesis
#17
(no author information available yet)
No abstract text is available yet for this article.
July 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29986049/response-to-h-chen-y-liu-p-li-and-d-zhu
#18
Yibing Yang, Xinya Gao, Maolei Zhang, Nu Zhang
No abstract text is available yet for this article.
July 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29986033/re-novel-role-of-fbxw7-circular-rna-in-repressing-glioma-tumorigenesis
#19
He Chen, Ying Liu, Peiling Li, Daling Zhu
No abstract text is available yet for this article.
July 6, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29982609/corrigendum
#20
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Journal of the National Cancer Institute
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