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Journal of the National Cancer Institute

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https://www.readbyqxmd.com/read/29771346/survivorship-care-plan-we-ve-got-the-tool-it-s-time-to-fix-the-process
#1
Larissa Nekhlyudov
No abstract text is available yet for this article.
May 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29771337/randomized-trial-of-the-impact-of-empowering-childhood-cancer-survivors-with-survivorship-care-plans
#2
Nina S Kadan-Lottick, Wilhelmenia L Ross, Hannah-Rose Mitchell, Jaime Rotatori, Cary P Gross, Xiaomei Ma
Background: A survivorship care plan (SCP), that is, individualized treatment summary and schedule of off-therapy surveillance, will be mandated by January 2019. It is unclear whether SCPs improve adherence to recommended follow-up care in the community. In this trial, we evaluated the impact of randomly assigning childhood cancer survivors to 1) SCPs to be taken to their primary care physician (PCP) to implement or 2) survivorship clinic (SC) on health care quality measures. Methods: Eligibility included cancer diagnosis younger than age 18 years (2000-2012), cancer free, one or more years off therapy, and no prior survivorship clinic attendance...
May 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29767749/association-of-brca2-k3326-with-small-cell-lung-cancer-and-squamous-cell-cancer-of-the-skin
#3
Thorunn Rafnar, Gudbjorg R Sigurjonsdottir, Simon N Stacey, Gisli Halldorsson, Patrick Sulem, Luba M Pardo, Hannes Helgason, Stefan T Sigurdsson, Thorkell Gudjonsson, Laufey Tryggvadottir, Gudridur H Olafsdottir, Jon G Jonasson, Kristin Alexiusdottir, Asgeir Sigurdsson, Julius Gudmundsson, Jona Saemundsdottir, Jon K Sigurdsson, Hrefna Johannsdottir, Andre Uitterlinden, Sita H Vermeulen, Tessel E Galesloot, Dawn C Allain, Martin Lacko, Bardur Sigurgeirsson, Kristin Thorisdottir, Oskar T Johannsson, Fridbjorn Sigurdsson, Gunnar B Ragnarsson, Helgi Isaksson, Hronn Hardardottir, Tomas Gudbjartsson, Daniel F Gudbjartsson, Gisli Masson, Lambertus A M L Kiemeney, Amanda Ewart Toland, Tamar Nijsten, Wilbert H M Peters, Jon H Olafsson, Steinn Jonsson, Unnur Thorsteinsdottir, Gudmar Thorleifsson, Kari Stefansson
Background: Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326* (rs11571833), confers risk of lung cancer and cancers of the upper-aero-digestive tract but only a modest risk of breast or ovarian cancer. The Icelandic population provides an opportunity for comprehensive characterization of the cancer risk profiles of K3326* and HBOC mutations because a single mutation, BRCA2 999del5, is responsible for almost all BRCA2-related HBOC in the population...
May 14, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29767746/mixing-mutation-location-with-carcinogen-exposure-a-recipe-for-tissue-specificity-in-brca2-associated-cancers
#4
Shailja Pathania, Judy E Garber
No abstract text is available yet for this article.
May 14, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29757403/the-ancestral-pace-of-variant-reclassification
#5
Sharon E Plon, Heidi L Rehm
No abstract text is available yet for this article.
May 10, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29757401/viral-therapy-gets-personal-a-potential-gene-signature-to-predict-susceptibility-to-measles-virus-oncolysis
#6
Peter A Forsyth, Daniel Abate-Daga
No abstract text is available yet for this article.
May 10, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29741696/long-term-cardiovascular-outcomes-among-endometrial-cancer-survivors-in-a-large-population-based-cohort-study
#7
Sean Soisson, Patricia A Ganz, David Gaffney, Kerry Rowe, John Snyder, Yuan Wan, Vikrant Deshmukh, Mike Newman, Alison Fraser, Ken Smith, Kimberly Herget, Heidi A Hanson, Yelena P Wu, Joseph Stanford, Ali Al-Sarray, Theresa L Werner, Veronica W Setiawan, Mia Hashibe
Background: Endometrial cancer is the second most common cancer among female cancer survivors in the United States. Cardiovascular disease is the leading cause of death among endometrial cancer survivors. Studies that examine long-term cardiovascular outcomes among endometrial cancer survivors are critical. Methods: Cohorts of 2648 endometrial cancer survivors diagnosed between 1997 and 2012 and 10 503 age-matched women from the general population were identified...
May 8, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29718396/potential-benefit-of-intra-operative-administration-of-ketorolac-on-breast-cancer-recurrence-according-to-the-patient-s-body-mass-index
#8
Christine Desmedt, Romano Demicheli, Marco Fornili, Imane Bachir, Mariana Duca, Giulia Viglietti, Martine Berlière, Martine Piccart, Christos Sotiriou, Maurice Sosnowski, Patrice Forget, Elia Biganzoli
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently used in some countries as analgesics in primary cancer surgery. Retrospective studies suggest that NSAIDs could reduce breast cancer recurrences. Because NSAIDs also act on biological mechanisms present in patients with increased adiposity, we aimed at assessing whether the intra-operative administration of ketorolac or diclofenac would be associated with a reduction of recurrence in patients with elevated body mass index (BMI)...
April 30, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29718287/harnessing-the-perioperative-period-to-improve-long-term-cancer-outcomes
#9
Shamgar Ben-Eliyahu, Talia Golan
No abstract text is available yet for this article.
April 30, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29718448/perspectives-on-ovarian-cancer-from-seer-today-and-tomorrow
#10
Daniel W Cramer, Kevin M Elias
No abstract text is available yet for this article.
April 28, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29718314/simulation-modeling-of-cancer-clinical-trials-application-to-omitting-radiotherapy-in-low-risk-breast-cancer
#11
Jinani Jayasekera, Yisheng Li, Clyde B Schechter, Reshma Jagsi, Juhee Song, Julia White, George Luta, Judith-Anne W Chapman, Eric J Feuer, Richard C Zellars, Natasha Stout, Thomas B Julian, Timothy Whelan, Xuelin Huang, E Shelley Hwang, Judith O Hopkins, Joseph A Sparano, Stewart J Anderson, Anthony W Fyles, Robert Gray, Willi Sauerbrei, Jeanne Mandelblatt, Donald A Berry
Background: We used two models to simulate a proposed noninferiority trial of radiotherapy (RT) omission in low-risk invasive breast cancer to illustrate how modeling could be used to predict the trial's outcomes, inform trial design, and contribute to practice debates. Methods: The proposed trial was a prospective randomized trial of no-RT vs RT in women age 40 to 74 years undergoing lumpectomy and endocrine therapy for hormone receptor-positive, human epidermal growth factor receptor 2-negative, stage I breast cancer with an Oncotype DX score of 18 or lower...
April 28, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29718305/invasive-epithelial-ovarian-cancer-survival-by-histotype-and-disease-stage
#12
Lauren C Peres, Kara L Cushing-Haugen, Martin Köbel, Holly R Harris, Andrew Berchuck, Mary Anne Rossing, Joellen M Schildkraut, Jennifer A Doherty
Background: The understanding of ovarian cancer pathogenesis has recently shifted to recognize distinct changes in how ovarian cancer histotypes are defined. Using the 2014 World Health Organization (WHO) diagnostic guidelines, we classified ovarian cancer histotypes in Surveillance, Epidemiology, and End Results (SEER) cancer registry data and examined survival patterns by histotype and disease stage. Methods: We extracted data on 28 118 incident epithelial ovarian cancer cases diagnosed in 2004-2014 from SEER and defined histotype using the 2014 WHO guidelines (high-grade serous, low-grade serous, endometrioid, clear cell, mucinous, carcinosarcoma, and malignant Brenner tumors)...
April 28, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29718453/molecular-landscape-of-erbb2-erbb3-mutated-colorectal-cancer
#13
Jonathan M Loree, Ann M Bailey, Amber M Johnson, Yao Yu, Wenhui Wu, Christopher A Bristow, Jennifer S Davis, Kenna R Shaw, Russell Broaddus, Kimberly C Banks, Richard B Lanman, Funda Meric-Bernstam, Michael J Overman, Scott Kopetz, Kanwal Raghav
Background: Despite growing therapeutic relevance of ERBB2 amplifications in colorectal cancer (CRC), little is known about ERBB2/ERBB3 mutations. We aimed to characterize these subsets of CRC. Methods: We performed a retrospective analysis of 419 CRC patients from MD Anderson (MDACC) and 619 patients from the Nurses' Health Study (NHS)/Health Professionals Follow-Up Study (HPFS) with tissue sequencing, clinicopathologic, mutational, and consensus molecular subtype (CMS) profiles of ERBB2/ERBB3 mutant patients...
April 27, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29688493/re-smoking-sex-and-non-small-cell-lung-cancer-steroid-hormone-receptors-in-tumor-tissue-s0424
#14
Hermann Nabi, Louise Provencher, Caroline Diorio
No abstract text is available yet for this article.
April 20, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29688488/response-to-h-nabi-et-al
#15
Ting-Yuan David Cheng, Amy K Darke, Mary W Redman, Karen Kelly, Regina M Santella, Kathy S Albain, Christine B Ambrosone
No abstract text is available yet for this article.
April 20, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29684152/association-between-proportion-of-nuclei-with-high-chromatin-entropy-and-prognosis-in-gynecological-cancers
#16
Birgitte Nielsen, Andreas Kleppe, Tarjei Sveinsgjerd Hveem, Manohar Pradhan, Rolf Anders Syvertsen, John Arne Nesheim, Gunnar Balle Kristensen, Jone Trovik, David James Kerr, Fritz Albregtsen, Håvard Emil Danielsen
Background: Nuclear texture analysis measuring differences in chromatin structure has provided prognostic biomarkers in several cancers. There is a need for improved cell-by-cell chromatin analysis to detect nuclei with highly disorganized chromatin. The purpose of this study was to develop a method for detecting nuclei with high chromatin entropy and to evaluate the association between the presence of such deviating nuclei and prognosis. Methods: A new texture-based biomarker that characterizes each cancer based on the proportion of high-chromatin entropy nuclei (<25% vs ≥25%) was developed on a discovery set of 175 uterine sarcomas...
April 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29684151/a-new-framework-for-patient-engagement-in-cancer-clinical-trials-cooperative-group-studies
#17
Patricia A Deverka, Rick Bangs, Karma Kreizenbeck, Deborah M Delaney, Dawn L Hershman, Charles D Blanke, Scott D Ramsey
For the past two decades, the National Cancer Institute (NCI) has supported the involvement of patient advocates in both internal advisory activities and funded research projects to provide a patient perspective. Implementation of the inclusion of patient advocates has varied considerably, with inconsistent involvement of patient advocates in key phases of research such as concept development. Despite this, there is agreement that patient advocates have improved the patient focus of many cancer research studies...
April 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29659933/circulating-tumor-cells-in-breast-cancer-patients-treated-by-neoadjuvant-chemotherapy-a-meta-analysis
#18
François-Clément Bidard, Stefan Michiels, Sabine Riethdorf, Volkmar Mueller, Laura J Esserman, Anthony Lucci, Bjørn Naume, Jun Horiguchi, Rafael Gisbert-Criado, Stefan Sleijfer, Masakazu Toi, Jose A Garcia-Saenz, Andreas Hartkopf, Daniele Generali, Françoise Rothé, Jeffrey Smerage, Laura Muinelo-Romay, Justin Stebbing, Patrice Viens, Mark Jesus M Magbanua, Carolyn S Hall, Olav Engebraaten, Daisuke Takata, José Vidal-Martínez, Wendy Onstenk, Noriyoshi Fujisawa, Eduardo Diaz-Rubio, Florin-Andrei Taran, Maria Rosa Cappelletti, Michail Ignatiadis, Charlotte Proudhon, Denise M Wolf, Jessica B Bauldry, Elin Borgen, Rin Nagaoka, Vicente Carañana, Jaco Kraan, Marisa Maestro, Sara Yvonne Brucker, Karsten Weber, Fabien Reyal, Dominic Amara, Mandar G Karhade, Randi R Mathiesen, Hideaki Tokiniwa, Antonio Llombart-Cussac, Alessandra Meddis, Paul Blanche, Koenraad d'Hollander, Klaus Pantel
Background: We conducted a meta-analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker. Methods: We collected individual patient data from 21 studies in which CTC detection by CellSearch was performed in early breast cancer patients treated with NCT. The primary end point was overall survival, analyzed according to CTC detection, using Cox regression models stratified by study...
April 12, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29659941/circulating-tumor-cells-in-patients-receiving-neoadjuvant-chemotherapy-refining-the-paradigm-of-prognosis-and-treatment-individualization
#19
Eleftherios P Mamounas
No abstract text is available yet for this article.
April 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29659930/automated-cervical-screening-and-triage-based-on-hpv-testing-and-computer-interpreted-cytology
#20
Kai Yu, Noorie Hyun, Barbara Fetterman, Thomas Lorey, Tina R Raine-Bennett, Han Zhang, Robin E Stamps, Nancy E Poitras, William Wheeler, Brian Befano, Julia C Gage, Philip E Castle, Nicolas Wentzensen, Mark Schiffman
Background: State-of-the-art cervical cancer prevention includes human papillomavirus (HPV) vaccination among adolescents and screening/treatment of cervical precancer (CIN3/AIS and, less strictly, CIN2) among adults. HPV testing provides sensitive detection of precancer but, to reduce overtreatment, secondary "triage" is needed to predict women at highest risk. Those with the highest-risk HPV types or abnormal cytology are commonly referred to colposcopy; however, expert cytology services are critically lacking in many regions...
April 11, 2018: Journal of the National Cancer Institute
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