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Journal of the National Cancer Institute

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https://www.readbyqxmd.com/read/28057711/higher-consumption-of-grilled-barbecued-and-smoked-meat-linked-to-increased-mortality-risk-among-breast-cancer-survivors
#1
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28052933/grilled-barbecued-and-smoked-meat-intake-and-survival-following-breast-cancer
#2
Humberto Parada, Susan E Steck, Patrick T Bradshaw, Lawrence S Engel, Kathleen Conway, Susan L Teitelbaum, Alfred I Neugut, Regina M Santella, Marilie D Gammon
BACKGROUND: Grilled, barbecued, and smoked meat intake, a prevalent dietary source of polycyclic aromatic hydrocarbon (PAH) carcinogens, may increase the risk of incident breast cancer. However, no studies have examined whether intake of this PAH source influences survival after breast cancer. METHODS: We interviewed a population-based cohort of 1508 women diagnosed with first primary invasive or in situ breast cancer in 1996 and 1997 at baseline and again approximately five years later to assess grilled/barbecued and smoked meat intake...
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040797/disease-subtype-independent-biomarkers-of-breast-cancer-chemoprevention-by-the-ayurvedic-medicine-phytochemical-withaferin-a
#3
Suman K Samanta, Anuradha Sehrawat, Su-Hyeong Kim, Eun-Ryeong Hahm, Yongli Shuai, Ruchi Roy, Subrata K Pore, Krishna B Singh, Susan M Christner, Jan H Beumer, Nancy E Davidson, Shivendra V Singh
BACKGROUND: A nontoxic chemopreventive intervention efficacious against different subtypes of breast cancer is still a clinically unmet need. The present study was undertaken to determine the efficacy of an Ayurvedic medicine phytochemical (Withaferin A, [WA]) for chemoprevention of breast cancer and to elucidate its mode of action. METHODS: Chemopreventive efficacy of WA (4 and 8 mg/kg body weight) was determined using a rat model of breast cancer induced by N-methyl-N-nitrosourea (MNU; n = 14 for control group, n = 15 for 4 mg/kg group, and n = 18 for 8 mg/kg group)...
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040796/role-of-rpl39-in-metaplastic-breast-cancer
#4
Bhuvanesh Dave, Daniel D Gonzalez, Zhi-Bin Liu, Xiaoxian Li, Helen Wong, Sergio Granados, Nadeer E Ezzedine, Douglas H Sieglaff, Joe E Ensor, Kathy D Miller, Milan Radovich, Agda KarinaEtrovic, Steven S Gross, Olivier Elemento, Gordon B Mills, Michael Z Gilcrease, Jenny C Chang
BACKGROUND: Metaplastic breast cancer is one of the most therapeutically challenging forms of breast cancer because of its highly heterogeneous and chemoresistant nature. We have previously demonstrated that ribosomal protein L39 (RPL39) and its gain-of-function mutation A14V have oncogenic activity in triple-negative breast cancer and this activity may be mediated through inducible nitric oxide synthase (iNOS). The function of RPL39 and A14V in other breast cancer subtypes is currently unknown...
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040795/weighing-risk-of-cardiovascular-mortality-against-potential-benefit-of-hormonal-therapy-in-intermediate-risk-prostate-cancer
#5
Nataniel H Lester-Coll, Skyler Johnson, William J Magnuson, Samuel Z Goldhaber, David J Sher, Anthony V D'Amico, James B Yu
BACKGROUND: The purpose of this study is to determine the optimal strategy for men with newly diagnosed intermediate-risk prostate cancer by age and cardiac risk. METHODS: A Markov model was calibrated to the EORTC 22991 trial, which randomly assigned men with intermediate-risk prostate cancer to radiation therapy (RT) with or without six months of hormonal therapy (HT). We compared quality-adjusted life-years (QALYs) in men age 50, 60, and 70 years by age decile and cardiac risk group...
June 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040695/kids-enter-the-match
#6
EDITORIAL
Gudrun Schleiermacher, Olivier Delattre
No abstract text is available yet for this article.
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040694/risk-factors-that-increase-risk-of-estrogen-receptor-positive-and-negative-breast-cancer
#7
Karla Kerlikowske, Charlotte C Gard, Jeffrey A Tice, Elad Ziv, Steven R Cummings, Diana L Miglioretti
BACKGROUND: Risk factors may differentially influence development of estrogen receptor (ER)-positive vs -negative breast cancer. We examined associations with strong, prevalent risk factors by ER subtype. METHODS: Of 1 279 443 women age 35 to 74 years participating in the Breast Cancer Surveillance Consortium, 14 969 developed ER-positive and 3617 developed ER-negative invasive breast cancer. We calculated hazard ratios (HRs) using Cox regression and compared ER subtype hazard ratios at representative ages or by menopausal status using Wald tests...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040693/influence-of-statins-and-cholesterol-on-mortality-among-patients-with-pancreatic-cancer
#8
Brian Z Huang, Jonathan I Chang, Erica Li, Anny H Xiang, Bechien U Wu
BACKGROUND: Recent studies have suggested associations between statins and enhanced survival among patients with pancreatic ductal adenocarcinoma (PDAC). However, the relationship between statins, cholesterol, and survival remains unclear. METHODS: We conducted a retrospective cohort study on 2142 PDAC patients in a regional integrated healthcare system from 2006 to 2014. Electronic pharmacy records were used to abstract information on the type, length, and dosage of statin exposures starting in the year prior to diagnosis...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040692/prognostic-value-of-braf%C3%A2-and%C3%A2-kras%C3%A2-mutations-in-msi-and-mss-stage-iii-colon-cancer
#9
Julien Taieb, Karine Le Malicot, Qian Shi, Frédérique Penault Lorca, Olivier Bouché, Josep Tabernero, Enrico Mini, Richard M Goldberg, Gunnar Folprecht, Jean Luc Van Laethem, Daniel J Sargent, Steven R Alberts, Jean Francois Emile, Pierre Laurent Puig, Frank A Sinicrope
BACKGROUND: The prognostic value of BRAF and KRAS mutations within microsatellite-unstable (MSI) and microsatellite-stable (MSS) subgroups of resected colon carcinoma patients remains controversial. We examined this question in prospectively collected biospecimens from stage III colon cancer with separate analysis of MSI and MSS tumors from patients receiving adjuvant FOLFOX +/- cetuximab in two adjuvant therapy trials. METHODS: Three groups were defined: BRAF Mutant, KRAS Mutant, and double wild-type...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040691/ultraviolet-radiation-and-kaposi-sarcoma-incidence-in-a-nationwide-us-cohort-of-hiv-infected-men
#10
Elizabeth K Cahoon, Eric A Engels, D Michal Freedman, Mary Norval, Ruth M Pfeiffer
BACKGROUND: Although ultraviolet radiation (UVR) is established as both an inducer of herpes simplex virus reactivation and as the primary risk factor for many common skin cancers, its relationship with human herpes virus 8 (HHV8) infection or risk of Kaposi sarcoma (KS) is unknown. METHODS: Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for the association between ambient UVR, history of nonmelanoma skin cancer (NMSC; as a biomarker of personal cumulative UVR dose), and incidence of first primary KS in a nationwide US cohort of white and African American male veterans infected with HIV between 1986 and 1996 (prior to the widespread availability of treatment) using Cox regression...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040690/obesity-and-the-transformation-of-monoclonal-gammopathy-of-undetermined-significance-to-multiple-myeloma-a-population-based-cohort-study
#11
Su-Hsin Chang, Suhong Luo, Theodore S Thomas, Katiuscia K O'Brian, Graham A Colditz, Nils P Carlsson, Kenneth R Carson
BACKGROUND: Multiple myeloma (MM) is one of the most common hematologic malignancies in the United States and is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). This study investigates the role of obesity in the progression of MGUS to MM. METHODS: A retrospective identified cohort of patients in the US Veterans Health Administration database diagnosed with MGUS between October 1, 1999, and December 31, 2009, was followed through August 6, 2013...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040701/thinking-critically-about-classifying-adverse-events-incidence-of-pancreatitis-in-patients-treated-with-nivolumab-ipilimumab
#12
Claire F Friedman, Varina Clark, Andrew V Raikhel, Tim Barz, Alexander N Shoushtari, Parisa Momtaz, Margaret K Callahan, Jedd D Wolchok, Paul B Chapman, Matthew D Hellmann, Michael A Postow
The Common Terminology Criteria for Adverse Events (CTCAE) were developed to document the adverse effects of chemotherapy but are now also used to document immune-related adverse events (irAE). Characterization of irAE by the CTCAE has implications for determining dose-limiting toxicity (DLT) and, consequently, the recommended phase II dose (RP2D) of investigational agents. In the phase I trial of nivolumab + ipilimumab, an asymptomatic increase in lipase was the primary DLT that informed the RP2D. We performed a retrospective study of 119 patients with melanoma who were treated at Memorial Sloan Kettering Cancer Center with the combination of nivolumab + ipilimumab to investigate the relationship between asymptomatic grade 3 or higher increases in amylase and/or lipase and pancreatitis, a known irAE...
April 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040700/hodgkin-lymphoma-current-status-and-clinical-trial-recommendations
#13
REVIEW
Catherine S Diefenbach, Joseph M Connors, Jonathan W Friedberg, John P Leonard, Brad S Kahl, Richard F Little, Lawrence Baizer, Andrew M Evens, Richard T Hoppe, Kara M Kelly, Daniel O Persky, Anas Younes, Lale Kostakaglu, Nancy L Bartlett
The National Clinical Trials Network lymphoid malignancies Clinical Trials Planning Meeting (CTPM) occurred in November of 2014. The scope of the CTPM was to prioritize across the lymphoid tumors clinically significant questions and to foster strategies leading to biologically informed and potentially practice changing clinical trials. This review from the Hodgkin lymphoma (HL) subcommittee of the CTPM discusses the ongoing clinical challenges in HL, outlines the current standard of care for HL patients from early to advanced stage, and surveys the current science with respect to biomarkers and the landscape of ongoing clinical trials...
April 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27986802/sequential-validation-of-blood-based-protein-biomarker-candidates-for-early-stage-pancreatic-cancer
#14
Michela Capello, Leonidas E Bantis, Ghislaine Scelo, Yang Zhao, Peng Li, Dilsher S Dhillon, Nikul J Patel, Deepali L Kundnani, Hong Wang, James L Abbruzzese, Anirban Maitra, Margaret A Tempero, Randall Brand, Lenka Brennan, Eleonora Feng, Ivana Taguchi, Vladimir Janout, Matthew A Firpo, Sean J Mulvihill, Matthew H Katz, Samir M Hanash
BACKGROUND: CA19-9, which is currently in clinical use as a pancreatic ductal adenocarcinoma (PDAC) biomarker, has limited performance in detecting early-stage disease. We and others have identified protein biomarker candidates that have the potential to complement CA19-9. We have carried out sequential validations starting with 17 protein biomarker candidates to determine which markers and marker combination would improve detection of early-stage disease compared with CA19-9 alone. METHODS: Candidate biomarkers were subjected to enzyme-linked immunosorbent assay based sequential validation using independent multiple sample cohorts consisting of PDAC cases (n = 187), benign pancreatic disease (n = 93), and healthy controls (n = 169)...
April 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27927756/surrogate-end-points-for-overall-survival-in-loco-regionally-advanced-nasopharyngeal-carcinoma-an-individual-patient-data-meta-analysis
#15
Federico Rotolo, Jean-Pierre Pignon, Jean Bourhis, Sophie Marguet, Julie Leclercq, Wai Tong Ng, Jun Ma, Anthony T C Chan, Pei-Yu Huang, Guopei Zhu, Daniel T T Chua, Yong Chen, Hai-Qiang Mai, Dora L W Kwong, Yoke Lim Soong, James Moon, Yuk Tung, Kwan-Hwa Chi, George Fountzilas, Li Zhang, Edwin Pun Hui, Anne W M Lee, Pierre Blanchard, Stefan Michiels
BACKGROUND: Our objective was to evaluate progression-free survival (PFS) and distant metastasis-free survival (DMFS) as surrogate end points for overall survival (OS) in randomized trials of chemotherapy in loco-regionally advanced nasopharyngeal carcinomas (NPCs). METHODS: Individual patient data were obtained from 19 trials of the updated Meta-Analysis of Chemotherapy in Nasopharyngeal Carcinoma (MAC-NPC) plus one additional trial (total = 5144 patients). Surrogacy was evaluated at the individual level using a rank correlation coefficient ρ and at the trial level using a correlation coefficient R(2) between treatment effects on the surrogate end point and OS...
April 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040699/recommendations-for-clinical-trial-development-in-follicular-lymphoma
#16
REVIEW
Kami Maddocks, Paul M Barr, Bruce D Cheson, Richard F Little, Lawrence Baizer, Brad S Kahl, John P Leonard, Nathan Fowler, Leo I Gordon, Brian K Link, Jonathan W Friedberg, Stephen M Ansell
Follicular lymphoma (FL) is the second most common lymphoid malignancy, representing 20% to 25% of all cases of non-Hodgkin's lymphoma (NHL), and the most common of the indolent NHLs. FL is considered incurable in the majority of patients with the current standard therapeutic approaches, although outcomes have improved in the last few decades with our current therapies, with a median overall survival that now exceeds 18 years. While the majority of patients with FL have improved outcomes with our current therapeutic approaches, there are patients with high-risk disease features that have inferior outcomes to these therapies...
March 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28034896/role-of-cps1-in-cell-growth-metabolism-and-prognosis-in-lkb1-inactivated-lung-adenocarcinoma
#17
Müge Çeliktaş, Ichidai Tanaka, Satyendra Chandra Tripathi, Johannes F Fahrmann, Clemente Aguilar-Bonavides, Pamela Villalobos, Oliver Delgado, Dilsher Dhillon, Jennifer B Dennison, Edwin J Ostrin, Hong Wang, Carmen Behrens, Kim-Anh Do, Adi F Gazdar, Samir M Hanash, Ayumu Taguchi
BACKGROUND: Liver kinase B1 (LKB1) is a tumor suppressor in lung adenocarcinoma (LADC). We investigated the proteomic profiles of 45 LADC cell lines with and without LKB1 inactivation. Carbamoyl phosphate synthetase 1 (CPS1), the first rate-limiting mitochondrial enzyme in the urea cycle, was distinctively overexpressed in LKB1-inactivated LADC cell lines. We therefore assessed the role of CPS1 and its clinical relevance in LKB1-inactivated LADC. METHODS: Mass spectrometric profiling of proteome and metabolome and function of CPS1 were analyzed in LADC cell lines...
March 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27986878/nonsteroidal-anti-inflammatory-drugs-and-endometrial-carcinoma-mortality-and-recurrence
#18
Theodore M Brasky, Ashley S Felix, David E Cohn, D Scott McMeekin, David G Mutch, William T Creasman, Premal H Thaker, Joan L Walker, Richard G Moore, Shashikant B Lele, Saketh R Guntupalli, Levi S Downs, Christa I Nagel, John F Boggess, Michael L Pearl, Olga B Ioffe, Kay J Park, Shamshad Ali, Louise A Brinton
BACKGROUND: Recent data suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reductions in endometrial cancer risk, yet very few have examined whether their use is related to prognosis among endometrial cancer patients. METHODS: Study subjects comprised 4374 participants of the NRG Oncology/Gynecology Oncology Group 210 Study with endometrial carcinoma who completed a presurgical questionnaire that assessed history of regular prediagnostic NSAID use and endometrial cancer risk factors...
March 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27795227/vitamin-b6-and-cancer-risk-a-field-synopsis-and-meta-analysis
#19
REVIEW
Simone Mocellin, Marta Briarava, Pierluigi Pilati
BACKGROUND: Vitamin B6 is involved in many biochemical reactions and might play a role in carcinogenesis. We summarized the evidence linking vitamin B6 to cancer risk. METHODS: We conducted a systematic review of both observational and intervention studies investigating the relationship between vitamin B6 intake or blood levels of its bioactive form pyridoxal-5'-phosphate (PLP) and the risk of any type of cancer. Random-effects meta-analysis was used to calculate pooled relative risks (RRs) and their 95% confidence intervals (CIs) across studies for high vs low categories of vitamin intake or PLP levels...
March 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27794035/linguistic-strategies-for-improving-informed-consent-in-clinical-trials-among-low-health-literacy-patients
#20
Janice L Krieger, Jordan M Neil, Yulia A Strekalova, Melanie A Sarge
BACKGROUND: Improving informed consent to participate in randomized clinical trials (RCTs) is a key challenge in cancer communication. The current study examines strategies for enhancing randomization comprehension among patients with diverse levels of health literacy and identifies cognitive and affective predictors of intentions to participate in cancer RCTs. METHODS: Using a post-test-only experimental design, cancer patients (n = 500) were randomly assigned to receive one of three message conditions for explaining randomization (ie, plain language condition, gambling metaphor, benign metaphor) or a control message...
March 2017: Journal of the National Cancer Institute
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