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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/29157732/rnase-7-strongly-promotes-tlr9-mediated-dna-sensing-by-human-plasmacytoid-dendritic-cells
#1
V Kopfnagel, S Wagenknecht, J Harder, K Hofmann, M Kleine, A Buch, B Sodeik, T Werfel
Plasmacytoid dendritic cells (pDCs) were described to accumulate in the skin of patients with psoriasis and to be recruited into the dermis upon allergen challenge in atopic dermatitis. Importantly, activation of pDCs in the skin has been identified as important initiator of psoriasis development. RNase 7 is one of the major antimicrobial peptides (AMP) secreted by keratinocytes and is expressed in significantly higher amounts in lesional skin of patients with atopic dermatitis or psoriasis than in healthy individuals...
November 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29138057/hidradenitis-suppurativa-like-lesions-associated-with-pharmacologic-inhibition-of-gamma-secretase
#2
Geraldine O'Sullivan Coyne, Therese S Woodring, Chyi-Chia R Lee, Alice P Chen, Heidi H Kong
No abstract text is available yet for this article.
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29138056/skin-specific-cd301b-dermal-dendritic-cells-drive-il-17-mediated-psoriasis-like-immune-response-in-mice
#3
Tae-Gyun Kim, Sung Hee Kim, Jeyun Park, Wanho Choi, Moah Sohn, Hye Young Na, Minseok Lee, Jae Won Lee, Soo Min Kim, Do-Young Kim, Hyoung-Pyo Kim, Jae-Hoon Choi, Chae Gyu Park, Min-Geol Lee
Conventional dendritic cells (cDCs) are composed of heterogeneous subsets commonly arising from DC-committed progenitors. A population of CD301b-expressing DCs has recently been identified in non-lymphoid barrier tissues such as skin. However, whether CD301b(+) DCs in the skin represent ontogenetically unique subpopulation of migratory cDCs has not been fully addressed. Here, we demonstrated that CD301b(+) dermal DCs were distinct subpopulation of FLT3L-dependent CD11b(+) cDC2 lineage which required an additional GM-CSF cue for the adequate development...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29138055/merkel-cells-sense-cooling-with-trpm8-channels
#4
Valentine Bouvier, Yann Roudaut, Nancy Osorio, Jean-Marc Aimonetti, Edith Ribot-Ciscar, Virginie Penalba, Thierry Merrot, Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Laurent Misery, Patrick Delmas, Marcel Crest
In the skin, Merkel cells (MCs) connect with keratinocytes and Aβ nerve fibers to form a touch receptor which functions as a slow adapting mechanoreceptor (SA1 receptor). In human and mouse MCs, we observed an increased concentration of intracellular Ca(2+) ions in response to cold temperature and transient receptor potential melastatine 8 (TRPM8) ion channel agonists. A reduction in the response to cooling and TRPM8 agonists occurred following addition of TRPM8 antagonists, as well as in TRPM8 knockout mice...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-up-regulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#5
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishment the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29138053/recessive-mutation-in-fam83g-associated-with-palmoplantar-keratoderma-and-exuberant-scalp-hair
#6
Thiviyani Maruthappu, Lisa A McGinty, Diana C Blaydon, Benjamin Fell, Arto Määttä, Rebecca Duit, Tim Hawkins, Kristin M Braun, Michael A Simpson, Edel A O'Toole, David P Kelsell
No abstract text is available yet for this article.
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29138052/intra-and-interfamilial-phenotype-variability-associated-with-mutations-in-%C3%AE-secretase-subunit-encoding-psenen
#7
Jorge Frank, Damian J Ralser, Regina C Betz
No abstract text is available yet for this article.
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29129600/mabp1-targeting-interleukin-1alpha-for-moderate-to-severe-hidradenitis-suppurativa-not-eligible-for-adalimumab-a-randomized-study
#8
Theodora Kanni, Maria Argyropoulou, Themistoklis Spyridopoulos, Aikaterini Pistiki, Michael Stecher, Charles A Dinarello, John Simard, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Patients with moderate to severe hidradenitis suppurativa (HS) failing adalimumab therapy, or those ineligible to receive it, remain a population with an unmet need. METHODS: 20 patients not eligible for adalimumab were randomized to receive 12 weeks blind treatment with placebo or MABp1, a true human antibody targeting interleukin (IL)-1alpha. HS clinical response score at week 12 was the primary endpoint. RESULTS: The primary endpoint was met in 10% and 60% of placebo- and MABp1-treated patients respectively (odds ratio 13...
November 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29129599/itk-and-rlk-inhibitor-prn694-improves-skin-disease-in-two-mouse-models-of-psoriasis
#9
Jessica M Fuhriman, Mårten C G Winge, Helena Haberstock-Debic, Jens Oliver Funk, J Michael Bradshaw, M Peter Marinkovich
The chronic and highly prevalent skin disorder psoriasis vulgaris is characterized by a hyperproliferative epidermis and aberrant immune activity. Many studies have highlighted the role of differentiated T lymphocytes in psoriasis progression. Several biologics are currently available that target pro-inflammatory cytokines produced by T-lymphocytes, but the need for improved therapies persists. The small molecule PRN694 covalently binds ITK and RLK, two TEC kinases activated downstream of T lymphocyte activation, both of which are upregulated in psoriatic skin...
November 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29128259/role-of-dysregulated-cytokine-signaling-and-bacterial-triggers-in-the-pathogenesis-of-cutaneous-t-cell-lymphoma
#10
Melania H Fanok, Amy Sun, Laura K Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, Charalampos Lazaris, Adriana Heguy, Mary E Laird, Mark S Sundrud, Cynthia Liu, Jeff Kutok, Rodrigo S Lacruz, Jo-Ann Latkowski, Iannis Aifantis, Niels Ødum, Kenneth B Hymes, Swati Goel, Sergei B Koralov
Cutaneous T cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The molecular and cellular etiology of this malignancy remains enigmatic and what role antigenic stimulation plays in the initiation and/or progression of the disease remains to be elucidated. Deep sequencing of the tumor genome revealed a highly heterogeneous landscape of genetic perturbations and transcriptome analysis of transformed T cells further highlighted the heterogeneity of this disease...
November 8, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29122575/identification-of-functional-patterns-of-androgenetic-alopecia-using-transcriptome-profiling-in-distinct-locations-of-hair-follicles
#11
Yong Miao, Qian Qu, Wei Jiang, Xiao-Min Liu, Pan-Li Shi, Zhe-Xiang Fan, Li-Juan Du, Gao-Feng Wang, Xiao-Nan Liu, Zhen-He Guo, Yang Liu, Fang Liu, Ya-Rui Liu, Zhi-Qi Hu
No abstract text is available yet for this article.
November 6, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29103820/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#12
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
November 3, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29104160/genome-wide-screen-for-micrornas-reveals-a-role-for-mir-203-in-melanoma-metastasis
#13
Warangkana Lohcharoenkal, Kunal Das Mahapatra, Lorenzo Pasquali, Caitrin Crudden, Lara Kular, Yeliz Z Akkaya Ulum, Lingyun Zhang, Ning Xu Landén, Leonard Girnita, Maja Jagodic, Mona Ståhle, Enikö Sonkoly, Andor Pivarcsi
Melanoma is one of the deadliest human cancers with no effective cure. MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression post-transcriptionally. Here, we compared the miRNome of primary and metastatic melanomas in TCGA dataset and found lower miR-203 abundance in metastatic melanoma. Lower level of miR-203 is associated with poor overall survival in metastatic disease. We found that the methylation levels of several CpGs in the MIR203 promoter negatively correlated with miR-203 expression and that treatment with the demethylating agent 5-azaC induced miR-203 expression, which is associated with demethylation of promoter CpGs, in melanoma cell lines...
November 2, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29111235/genomic-stability-in-syndromic-basal-cell-carcinoma
#14
Audris Chiang, Prajakta D Jaju, Prag Batra, Melika Rezaee, Ervin H Epstein, Jean Y Tang, Kavita Y Sarin
Basal cell cancers (BCCs) are characterized by up-regulation of Hedgehog pathway through loss of Patched1 or activation of Smoothened, and smoothened-inhibitors such as vismodegib are effective therapies for advanced BCCs. Although most BCCs are sporadic, rare individuals with Basal Cell Nevus Syndrome (BCNS) harbor germline defects in Patched1 and develop up to hundreds of tumors that are histopathologically indistinguishable from sporadic BCCs. Interestingly, BCNS-BCCs are more responsive to Smoothened-inhibitors than sporadic BCCs, with minimal development of resistance...
October 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29111234/exacerbation-and-prolongation-of-psoriasiform-inflammation-in-diabetic-obese-mice-a-synergistic-role-of-cxcl5-and-er-stress
#15
Noriko Shimoura, Hiroshi Nagai, Susumu Fujiwara, Haruki Jimbo, Chikako Nishigori
Accumulating evidence suggests that psoriasis is frequently accompanied by metabolic disorders such as obesity and diabetes. However, the mechanisms underlying the association between increased psoriasis severity and concomitant metabolic syndrome have not been fully clarified. Herein, we show that imiquimod-induced psoriasiform inflammation was exacerbated and prolonged in diabetic obese mice compared to that in control mice, accompanied by remarkably increased lesional expressions of Cxcl5 and Il-1b. Notably, a large number of CXCL5(+) Ly6G(+) cells infiltrated the dermis and subcutaneous fat tissue of the diabetic obese mice...
October 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29104161/risk-of-incident-liver-disease-in-patients-with-psoriasis-psoriatic-arthritis-and-rheumatoid-arthritis-a-population-based-study
#16
Alexis Ogdie, Sungat K Grewal, Megan H Noe, Daniel Shin, Junko Takeshita, Zelma C Chiesa Fuxench, Rotonya M Carr, Joel M Gelfand
Relatively little is known about the risk for incident liver disease in psoriasis (PsO), psoriatic arthritis (PsA), and rheumatoid arthritis (RA). We performed a cohort study among patients with PsO, PsA, or RA and matched controls in The Health Improvement Network from 1994-2014. Outcomes of interest were any liver disease, non-alcoholic fatty liver disease (NAFLD), and cirrhosis (any etiology). Among patients with psoriasis (N=197,130), PsA (N=12,308), RA (N=54,251), and matched controls (N=1,279,754), the adjusted hazard ratios for any liver disease were elevated among patients with PsO (without systemic therapy HR 1...
October 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29106932/evaluating-stz-induced-impaired-wound-healing-in-rats
#17
David M Ansell, Charlotte Marsh, Liam Walker, Matthew J Hardman, Kirsty Holden
No abstract text is available yet for this article.
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29106931/interplay-between-keratinocytes-and-myeloid-cells-drives-dengue-virus-spread-in-human-skin
#18
Parichat Duangkhae, Geza Erdos, Kate D Ryman, Simon C Watkins, Louis D Falo, Ernesto T A Marques, Simon M Barratt-Boyes
The skin is the site of dengue virus (DENV) transmission following the bite of an infected mosquito, but the contribution of individual cell types within skin to infection is unknown. We studied the dynamics of DENV infection in human skin explants using quantitative in situ imaging. DENV replicated primarily in the epidermis and induced a transient interferon-α response. DENV infected a wide range of cells, including Langerhans cells, macrophages, dermal dendritic cells (DC), mast cells, fibroblasts and lymphatic endothelium, but keratinocytes were the earliest targets of infection and made up 60% of infected cells over time...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29106930/topical-inhibition-of-the-electron-transport-chain-can-stimulate-the-hair-cycle
#19
M Miranda, H Christofk, D L Jones, W E Lowry
While many signaling pathways have been implicated in control of activation of adult hair follicle stem cells and the hair cycle, less is known about cell intrinsic mechanisms of stem cell control. We previously identified lactate production as a key cell intrinsic regulator of hair follicle stem cell activity, suggesting that cellular metabolism is important in stem cell activation. Others have used transgenic methods to suggest that transgenic blockade of the Electron Transport Chain (ETC) leads to degeneration of the hair follicle...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29106929/gentamicin-induced-readthrough-and-nonsense-mediated-mrna-decay-of-serpinb7-nonsense-mutant-transcripts
#20
Yuka Ohguchi, Toshifumi Nomura, Shotaro Suzuki, Masae Takeda, Toshinari Miyauchi, Osamu Mizuno, Satoru Shinkuma, Yasuyuki Fujita, Osamu Nemoto, Kota Ono, W H Irwin McLean, Hiroshi Shimizu
Nagashima-type palmoplantar keratosis (NPPK) is an autosomal recessive skin disorder with a high, unmet medical need that is caused by mutations in SERPINB7. Almost all NPPK patients carry the founder nonsense mutation c.796C>T (p.Arg266Ter) in the last exon of SERPINB7. Here we sought to determine whether topical "nonsense-suppression (readthrough)" therapy using gentamicin is applicable to NPPK. First, we demonstrated that gentamicin enhanced readthrough activity in cells transfected with SERPINB7 cDNA carrying the mutation and promoted full-length SERPINB7 protein synthesis in NPPK keratinocytes...
October 26, 2017: Journal of Investigative Dermatology
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