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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/28108301/pfkfb3-a-direct-target-of-p63-is-required-for-proliferation-and-inhibits-differentiation-in-epidermal-keratinocytes
#1
Robert B Hamanaka, Gökhan M Mutlu
p63 is a transcription factor essential for epidermal development and homeostasis. p63 is a member of the p53 family of transcription factors, which are increasingly understood to be regulators of cellular metabolism. How p63 regulates metabolism in epidermal keratinocytes is incompletely understood, and it is unknown whether glycolytic regulation is essential to maintain the balance between proliferation and differentiation within the epidermis. We found that p63 promotes glycolytic metabolism in epidermal keratinocytes...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28108300/transforming-growth-factor-beta-inducible-early-gene-1-tieg1-represses-smad7-mediated-activation-of-tgf-%C3%AE-1-smad-signaling-in-keloid-pathogenesis
#2
Zhi-Cheng Hu, Fen Shi, Peng Liu, Jian Zhang, Dong Guo, Xiao-Ling Cao, Chu-Fen Chen, Shanqiang Qu, Jia-Yuan Zhu, Bing Tang
Transforming growth factor β (TGF-β)/Smad signaling plays a key role in excessive fibrosis and keloid formations. Smad7 is a negative feedback regulator that prevents activation of TGF-β/Smad signaling. However, the regulatory mechanism for Smad7 in the keloid pathogenic process remains elusive. Here, we show that expression of TGF-β inducible early gene-1 (TIEG1) is markedly higher in keloid fibroblasts (KFs), while protein, mRNA, and promoter activity levels of Smad7 are decreased. When TIEG1 was knocked down with small interfering RNA (siRNA), both the promoter activity and protein expression of Smad7 were increased, while collagen production and the proliferation, migration, and invasion of KFs were decreased...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28108299/mouse-model-of-hydroquinone-hypersensitivity-via-innate-and-acquired-immunity-and-its-promotion-by-combined-reagents
#3
Kanan Bando, Yukinori Tanaka, Toshinobu Kuroishi, Keiichi Sasaki, Teruko Takano-Yamamoto, Shunji Sugawara, Yasuo Endo
We established a mouse model of contact hypersensitivity (CHS) to hydroquinone (HQ), a widespread chemical in our environment. HQ was painted onto flanks. Then, HQ was challenged by painting onto ear-pinnas on days 7 and 14. The CHS after the 2(nd) challenge was markedly greater than that after the 1(st) challenge. Both challenges increased thymic stromal lymphopoietin (TSLP) and Th2 cytokines in ear-pinnas, while IFN-γ (typical Th1 cytokine) was decreased, despite an increase in IL-18 (typical IFN-γ inducer)...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28108298/trichodysplasia-spinulosa-polyomavirus-infection-occurs-during-early-childhood-with-intra-familial-transmission-especially-from-mother-to-child
#4
Vincent Pedergnana, Claire Martel-Jantin, Jérôme Tj Nicol, Valérie Leblond, Patricia Tortevoye, Pierre Coursaget, Antoine Touzé, Laurent Abel, Antoine Gessain
To get new insights into the distribution and modes of acquisition of trichodysplasia spinulosa polyomavirus (TSPyV) infection, we performed a seroepidemiological study in two populations from Cameroon. Our results suggest that TSPyV infection occurs, through close contacts, during early childhood with intra-familial transmission, especially from mother to child.
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28108297/the-leukotriene-b4-and-its-receptor-blt1-act-as-critical-drivers-of-neutrophil-recruitment-in-murine-bullous-pemphigoid-like-epidermolysis-bullosa-acquisita
#5
Tanya Sezin, Matthias Krajewski, Adam Wutkowski, Sadegh Mousavi, Lenche Chakievska, Katja Bieber, Ralf J Ludwig, Markus Dahlke, Dirk Rades, Franziska S Schulze, Enno Schmidt, Kathrin Kalies, Yask Gupta, Paul Schilf, Saleh M Ibrahim, Peter König, Dominik Schwudke, Detlef Zillikens, Christian D Sadik
Recruitment of neutrophils and eosinophils into the skin is a hallmark of pemphigoid diseases. The molecular cues regulating granulocyte recruitment into the skin as well as the individual contribution of neutrophils and eosinophils to pemphigoid diseases are, however, poorly understood. The lipid mediator leukotriene B4 (LTB4) is a potent granulocyte chemoattractant and abundant in the skin blister fluid of bullous pemphigoid (BP) patients, but its pathogenic significance is unknown. Using mouse models of (BP)-like epidermolysis bullosa acquisita (EBA) and of BP, we show that LTB4 and its receptor BLT1 act as critical drivers of neutrophil entry into the skin upon antibody deposition at the dermal-epidermal junction...
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28108296/are-idiopathic-stevens-johnson-syndrome-toxic-epidermal-necrolysis-related-to-drugs-in-food-example-of-phenylbutazone
#6
Cynthia Haddad, Olivier Chosidow, Laurence Valeyrie-Allanore, Bijan Ghaleh, Tiphaine Legrand, Maja Mockenhaupt, Caroline Barau, Nihel Khoudour, Peggy Sekula, Pierre Wolkenstein, Anne Hulin
No abstract text is available yet for this article.
January 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28104378/immune-checkpoint-molecule-vista-regulates-t-cell-mediated-skin-inflammatory-responses
#7
Tatsukuni Ohno, Yuta Kondo, Chenyang Zhang, Siwen Kang, Miyuki Azuma
No abstract text is available yet for this article.
January 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28089682/prevalence-and-risk-of-inflammatory-bowel-disease-in-patients-with-hidradenitis-suppurativa
#8
Alexander Egeberg, Gregor B E Jemec, Alexa B Kimball, Hervé Bachelez, Gunnar H Gislason, Jacob P Thyssen, Lotus Mallbris
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease (IBD) has been associated with increased prevalence of HS, but data on the concurrence of IBD in patients with HS is limited. We therefore investigated the prevalence and risk of IBD in patients with HS compared with the general population. The study linked all Danish individuals ≥18 years in nationwide registers. Adjusted odds ratios (OR) and adjusted hazard ratios (HRs) were estimated by logistic regression and Cox regression, respectively...
January 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28089201/recent-advances-in-melanoma-and-melanocyte-biology
#9
REVIEW
Hensin Tsao, Mizuho Fukunaga-Kalabis, Meenhard Herlyn
No abstract text is available yet for this article.
January 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28087452/congenital-anonychia-and-uncombable-hair-syndrome-co-inheritance-of-homozygous-mutations-in-rspo4-and-padi3
#10
Chao-Kai Hsu, Maria Teresa Romano, Arti Nanda, Ellie Rashidghamat, John Y W Lee, Hsin-Yu Huang, Chankiat Songsantiphap, Julia Yu-Yun Lee, Hejab Al-Ajmi, Regina C Betz, Michael A Simpson, John A McGrath, Christos Tziotzios
No abstract text is available yet for this article.
January 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28082186/the-abnormal-architecture-of-healed-diabetic-ulcers-is-the-result-of-fak-degradation-by-calpain-1
#11
Wei Liu, Kun Ma, Sun Hyung Kwon, Ravi Garg, Yoda R Patta, Toshihiro Fujiwara, Geoffrey C Gurtner
Delayed wound healing is a major complication of diabetes occurring in about 15% of chronic diabetic patients. It not only significantly affects patients' quality of life but also poses a major economic burden to the healthcare system. Most efforts have been focused on accelerating wound re-epithelialization and closure. However, even after healing the quality of healed tissue in diabetics is abnormal and recurrence is common (50-75%). Thus, understanding how diabetes alters the ultimate mechanical properties of healed wounds will be important to develop more effective approaches for this condition...
January 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28082185/uva1-induced-skin-darkening-is-associated-with-molecular-changes-even-in-highly-pigmented-skin-individuals
#12
Claire Marionnet, Stéphanie Nouveau, Virginie Hourblin, Kumar Pillai, Megan Manco, Philippe Bastien, Christian Tran, Caroline Tricaud, Olivier de Lacharrière, Françoise Bernerd
No abstract text is available yet for this article.
January 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28063651/recent-highlights-in-psoriasis-research
#13
REVIEW
Samuel T Hwang, Tamar Nijsten, James T Elder
This article highlights recent advances in the immunology, epidemiology, and genetics/genomics of psoriasis from 2015 through 2016. Advances sometimes generate more questions, and this article makes an attempt to point out where controversies might exist in the literature. Many of the articles mentioned were published in the Journal of Investigative Dermatology, but many articles from the broader scientific literature are also cited, to provide context and to add further validity for some of these key findings...
January 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28063650/performing-skin-microbiome-research-a-method-to-the-madness
#14
REVIEW
Heidi H Kong, Björn Andersson, Thomas Clavel, John E Common, Scott A Jackson, Nathan D Olson, Julia A Segre, Claudia Traidl-Hoffmann
Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis. The need for common language, effective study design, and validated methods is critical for high-quality standardized research. Features, unique to skin, pose particular challenges when conducting microbiome research. This review discusses microbiome research standards and highlights important factors to consider, including clinical study design, skin sampling, sample processing, DNA sequencing, control inclusion, and data analysis...
January 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28027893/correction-of-recessive-dystrophic-epidermolysis-bullosa-by-transposon-mediated-integration-of-col7a1-in-transplantable-patient-derived-primary-keratinocytes
#15
Maria Carmela Latella, Fabienne Cocchiarella, Laura De Rosa, Giandomenico Turchiano, Manuel A F V Gonçalves, Fernando Larcher, Michele De Luca, Alessandra Recchia
Recessive dystrophic epidermolysis bullosa (RDEB) is caused by defects in type-VII collagen (C7), a protein encoded by the COL7A1 gene and essential for anchoring fibril formation at the dermal-epidermal junction. Gene therapy of RDEB is based on transplantation of autologous epidermal grafts generated from gene-corrected keratinocytes sustaining C7 deposition at the dermal-epidermal junction. Transfer of the COL7A1 gene is complicated by its very large size and repetitive sequence. We report a gene delivery approach based on the Sleeping beauty transposon, which allows integration of a full-length COL7A1 cDNA and secretion of C7 at physiological levels in RDEB keratinocytes without rearrangements or detrimental effects on their clonogenic potential...
December 24, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28017833/protein-palmitoylation-by-zdhhc13-protects-skin-against-microbial-driven-dermatitis
#16
Li-Ying Chen, Hsin-Fang Yang-Yen, Chun-Chou Tsai, Christina Li-Ping Thio, Hsiao-Li Chuang, Liang-Tung Yang, Li-Fen Shen, I-Wen Song, Kai-Ming Liu, Yen-Te Huang, Fu-Tong Liu, Ya-Jen Chang, Yuan-Tsong Chen, Jeffrey J Y Yen
Atopic dermatitis (AD) is a complex chronic inflammatory skin disorder that results from intimate interactions between genetic predisposition, host environment, skin barrier defects, and immunological factors. However, a clear genetic roadmap leading to AD remains to be fully explored. From a genome-wide mutagenesis screen, deficiency of ZDHHC13, a palmitoylacyl transferase, has previously been associated with skin and multi-tissue inflammatory phenotypes. Here, we report that ZDHHC13 is required for skin barrier integrity and that deficiency of ZDHHC13 renders mice susceptible to environmental bacteria, resulting in persistent skin inflammation and an AD-like disease...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28017832/autosomal-recessive-keratoderma-ichthyosis-deafness-arkid-syndrome-is-caused-by-vps33b-mutations-affecting-rab-protein-interaction-and-collagen-modification
#17
Robert Gruber, Clare Rogerson, Christian Windpassinger, Blerida Banushi, Anna Straatman-Iwanowska, Joanna Hanley, Federico Forneris, Robert Strohal, Peter Ulz, Debra Crumrine, Gopinathan K Menon, Stefan Blunder, Matthias Schmuth, Thomas Müller, Holly Smith, Kevin Mills, Peter Kroisel, Andreas R Janecke, Paul Gissen
Here we report three patients with severe palmoplantar keratoderma associated with ichthyosis and sensorineural deafness. Bi-allelic mutations were found in VPS33B, encoding VPS33B, a Sec1/Munc18 family protein which interacts with Rab11a and Rab25 proteins and is involved in trafficking of the collagen modifying enzyme LH3. Two patients were homozygous for the missense variant p.Gly131Glu, whilst one patient was compound heterozygous for p.Gly131Glu and the splice site mutation c.240-1G>C, previously reported in patients with Arthrogryposis Renal dysfunction and Cholestasis syndrome...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28017831/stress-signals-mediated-by-membranous-glucocorticoid-receptor-activate-plc-pkc-gsk-3%C3%AE-%C3%AE-catenin-pathway-to-inhibit-wound-closure
#18
Ivan Jozic, Sasa Vukelic, Olivera Stojadinovic, Liang Liang, Horacio A Ramirez, Irena Pastar, Marjana Tomic Canic
Glucocorticoids (GCs), key mediators of stress signals, are also potent wound healing inhibitors. To understand how stress signals inhibit wound healing, we investigated the role of membranous glucocorticoid receptor (mbGR) by using cell-impermeable BSA-conjugated Dexamethasone. We found that mbGR inhibits keratinocyte migration and wound closure by activating a Wnt-like PLC/PKC signaling cascade. Rapid activation of mbGR/PLC/PKC further leads to activation of known biomarkers of non-healing found in patients, β-catenin and c-myc...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28017830/dermal-fibroblasts-promote-alternative-macrophage-activation-improving-impaired-wound-healing
#19
Rubén A Ferrer, Anja Saalbach, Mike Grünwedel, Nadine Lohmann, Inka Forstreuter, Susann Saupe, Elke Wandel, Jan C Simon, Sandra Franz
Tight control of inflammation is required for tissue repair such as wound healing and depends on alternative polarization of macrophages as check-point for inflammatory resolution. Its perturbations lead to impaired regeneration and administration of cells/cell factors capable of reversing inflammation and rescuing alternative polarization could be promising for treating inflammatory diseases. We show that human dermal fibroblasts (dFb) are ideal candidates for such a task by demonstrating a new function of these cells, which is modulating macrophage-polarization...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28012718/skin-resident-effector-memory-cd8-cd28-t-cells-exhibit-a-pro-fibrotic-phenotype-in-patients-with-systemic-sclerosis
#20
Gang Li, Adriana T Larregina, Robyn T Domsic, Donna B Stolz, Thomas A Medsger, Robert Lafyatis, Patrizia Fuschiotti
Loss of CD28 expression by CD8+ T cells occurs with age and during chronic inflammatory conditions. CD8+CD28- T cells are a heterogeneous cell subpopulation whose function ranges from immunosuppressive to effector. Here we analyzed the role of CD8+CD28- T cells in the pathogenesis of systemic sclerosis (SSc), a connective tissue disorder characterized by autoimmunity, vasculopathy and extensive cutaneous and visceral fibrosis. We show that the frequency of CD8+CD28- T cells is increased in the blood and affected skin of SSc patients, independent of patient age, and correlates with the extent of skin fibrosis...
December 21, 2016: Journal of Investigative Dermatology
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