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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/29777657/mcv-mir-m1-targets-the-host-cell-immune-response-resulting-in-the-attenuation-of-neutrophil-chemotaxis
#1
P Akhbari, D Tobin, K Poterlowicz, W Roberts, J R Boyne
Virus-encoded miRNAs are emerging as key regulators of persistent infection and host-cell immune evasion. Merkel cell polyomavirus (MCPyV), the predominant aetiological agent of Merkel cell carcinoma (MCC), encodes a single miRNA, MCV-miR-M1, which targets the oncogenic MCPyV large T antigen (LT). MCV-miR-M1 has previously been shown to play an important role in establishment of long-term infection, however, the underlying mechanism is not fully understood. A key unanswered question is whether, in addition to auto-regulating LT, MCV-miR-M1 also targets cellular transcripts to orchestrate an environment conducive for persistent infection...
May 16, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29775633/braf-v600e-mutations-in-nevi-and-melanocytic-tumors-of-uncertain-malignant-potential-meltumps
#2
Ruth Seitz-Alghrouz, Jose Villacorta Hidalgo, Claudia Kayser, Clemens Kreutz, Kristin Technau-Hafsi, Carlos Diaz, Andreas von Deimling, Jens Timmer, Martin Werner, Miroslav Malkovsky, Paul Fisch
No abstract text is available yet for this article.
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#3
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29758285/filaggrin-2-deficiency-results-in-abnormal-cell-cell-adhesion-in-the-cornified-cell-layers-and-causes-peeling-skin-syndrome-type-a
#4
Janan Mohamad, Ofer Sarig, Lisa M Godsel, Alon Peled, Natalia Malchin, Ron Bochner, Dan Vodo, Tom Rabinowitz, Mor Pavlovsky, Shahar Taiber, Maya Fried, Marina Eskin-Schwartz, Siwar Assi, Noam Shomron, Jouni Uitto, Jennifer L Koetsier, Reuven Bergman, Kathleen J Green, Eli Sprecher
Peeling skin syndromes form a large and heterogeneous group of inherited disorders characterized by superficial detachment of the epidermal cornified cell layers, often associated with inflammatory features. Here we report on a consanguineous family featuring non-inflammatory peeling of the skin exacerbated by exposure to heat and mechanical stress. Whole exome sequencing revealed a homozygous nonsense mutation in FLG2, encoding filaggrin 2, which co-segregated with the disease phenotype in the family. The mutation was found to result in decreased FLG2 RNA levels as well almost total absence of filaggrin 2 in the patient epidermis...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29758284/intradermal-injection-of-bone-marrow-msc-corrects-recessive-dystrophic-epidermolysis-bullosa-in-a-xenograft-model
#5
Clarisse Ganier, Matthias Titeux, Sonia Gaucher, Juliette Peltzer, Marc Le Lorc'h, Jean-Jacques Lataillade, Akemi Ishida-Yamamoto, Alain Hovnanian
No abstract text is available yet for this article.
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29758283/tgf-%C3%AE-fibronectin-and-integrin-%C3%AE-5%C3%AE-1-promote-invasion-in-basal-cell-carcinoma
#6
François Kuonen, Isabelle Surbeck, Kavita Y Sarin, Monique Dontenwill, Curzio Ruegg, Michel Gilliet, Anthony E Oro, Olivier Gaide
Basal cell carcinoma (BCC) is the most frequent human cancer and is becoming an important health problem in an ageing population. Based on their clinical and histological characteristics, thick BCC are typically divided into low-risk nodular and high-risk infiltrative subtypes, although the underlying mechanisms are poorly understood. We have identified molecular mechanisms that explain the aggressiveness of high-risk infiltrative BCC, with a potential direct clinical impact. In this study, we first show that fibroblasts, TGFβ and fibronectin are found preferentially in infiltrative human BCC...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29758282/stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-multicenter-retrospective-study-of-377-adult-patients-from-the-united-states
#7
Robert G Micheletti, Zelma Chiesa-Fuxench, Megan H Noe, Sasha Stephen, Maria Aleshin, Ashwin Agarwal, Jennifer Boggs, Adela R Cardones, Jennifer K Chen, Jonathan Cotliar, Mark Dp Davis, Arturo Dominguez, Lindy P Fox, Shayna Gordon, Ronald Hamrick, Baran Ho, Lauren C Hughey, Larry M Jones, Benjamin H Kaffenberger, Kimball Kindley, Daniela Kroshinsky, Bernice Y Kwong, Daniel D Miller, Arash Mostaghimi, Amy Musiek, Alex G Ortega-Loayza, Raj Patel, Alba Posligua, Monica Rani, Sandeep Saluja, Victoria R Sharon, Kanade Shinkai, Jessica St John, Nicole Strickland, Erika M Summers, Natalie Sun, Karolyn A Wanat, David A Wetter, Scott Worswick, Caroline Yang, David J Margolis, Joel M Gelfand, Misha Rosenbach
Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69.0% from 2010 onward. The most frequent cause of SJS/TEN was medication reaction (89.7%), most often trimethoprim / sulfamethoxazole (27...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29758281/purinergic-molecules-in-the-epidermis
#8
Youichi Ogawa, Manao Kinoshita, Nao Mizumura, Shiho Miyazaki, Rui Aoki, Akira Momosawa, Shinji Shimada, Taiho Kambe, Tatsuyoshi Kawamura
No abstract text is available yet for this article.
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29758280/multi-kinase-inhibitor-with-anti-p38%C3%AE-activity-in-cutaneous-t-cell-lymphoma
#9
Xu Hannah Zhang, Sangkil Nam, Jun Wu, Chih-Hong Chen, Xuxiang Liu, Hongzhi Li, Timothy McKeithan, Qiang Gong, Wing C Chan, Hongwei Holly Yin, Yate-Ching Yuan, Raju Pillai, Christiane Querfeld, David Horne, Yuan Chen, Steven T Rosen
Current cutaneous T cell lymphoma (CTCL) therapies are marked by an abbreviated response, subsequent drug resistance, and poor prognosis for patients with advanced disease. An understanding of molecular regulators involved in CTCL is needed to develop effective targeted therapies. One candidate regulator is p38γ, a mitogen-activated protein kinase crucial for malignant T cell activity and growth. p38γ gene expression is selectively increased in CTCL patient samples as well as cell lines, but not in healthy T cells...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29753707/reduced-microbial-diversity-is-a-feature-of-recessive-dystrophic-epidermolysis-bullosa-involved-skin-and-wounds
#10
Ignacia Fuentes, Christina Guttmann-Gruber, Angeline Su Ling Tay, Josefina Piñón Hofbauer, Simon L I J Denil, Julia Reichelt, Francis Palisson, John E A Common, Andrew P South
No abstract text is available yet for this article.
May 10, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29753032/enhancement-of-cutaneous-wound-healing-by-dsg2-augmentation-of-upar-secretion
#11
Felicia Cooper, Andrew M Overmiller, Anthony Loder, Donna M Brennan-Crispi, Kathleen P McGuinn, Molly R Marous, Theresa A Freeman, Natalia A Riobo-Del Galdo, Linda D Siracusa, James K Wahl, Mỹ G Mahoney
In addition to playing a role in adhesion, desmoglein 2 (Dsg2) is an important regulator of growth and survival signaling pathways, cell proliferation, migration and invasion, and oncogenesis. While low-level Dsg2 expression is observed in basal keratinocytes and is downregulated in non-healing venous ulcers, overexpression has been observed in both melanomas and non-melanoma malignancies. Here, we show that transgenic mice overexpressing Dsg2 in basal keratinocytes primed the activation of mitogenic pathways, but did not induce dramatic epidermal changes or susceptibility to chemical-induced tumor development...
May 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29753031/antiseptic-agents-elicit-short-term-personalized-and-body-site-specific-shifts-in-resident-skin-bacterial-communities
#12
Adam J SanMiguel, Jacquelyn S Meisel, Joseph Horwinski, Qi Zheng, Charles W Bradley, Elizabeth A Grice
Despite critical functions in cutaneous health and disease, it is unclear how resident skin microbial communities are altered by topical antimicrobial interventions commonly used in personal and clinical settings. Here we show that acute exposure to antiseptic treatments elicits rapid but short-term depletion of microbial community diversity and membership. Thirteen subjects were enrolled in a longitudinal treatment study to analyze the effects of topical treatments (ethanol, povidone-iodine, chlorhexidine, water) on the skin microbiome at two skin sites of disparate microenvironment: forearm and back...
May 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29753030/elastase-digestion-of-fibronectin-releases-an-epiviosamine-peptide-with-fibroblast-growth-and-survival-activity
#13
Kevin Lin, Fubao Lin, Richard A Clark
No abstract text is available yet for this article.
May 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29753029/inherited-genetic-variants-associated-with-melanoma-braf-nras-subtypes
#14
Nancy E Thomas, Sharon N Edmiston, Irene Orlow, Peter A Kanetsky, Li Luo, David C Gibbs, Eloise A Parrish, Honglin Hao, Klaus J Busam, Bruce K Armstrong, Anne Kricker, Anne E Cust, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, David W Ollila, Colin B Begg, Marianne Berwick, Kathleen Conway
BRAF and NRAS mutations arise early in melanoma development but their associations with low-penetrance melanoma susceptibility loci remain unknown. In the Genes, Environment and Melanoma (GEM) Study, 1223 European-origin participants had their incident invasive primary melanomas screened for BRAF/NRAS mutations and germline DNA genotyped for 47 single-nucleotide polymorphisms (SNPs) identified as low-penetrant melanoma risk variants. We used multinomial logistic regression to simultaneously examine each SNP's relationship to BRAF V600E, BRAF V600K, BRAF other, and NRAS+ relative to BRAF-/NRAS- melanoma adjusted for study features...
May 9, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29751003/special-at-rich-binding1-protein-satb1-in-malignant-t-cells
#15
Simon Fredholm, Andreas Willerslev-Olsen, Özcan Met, Linda Kubat, Maria Gluud, Sarah L Mathiasen, Christina Friese, Edda Blümel, David L Petersen, Tengpeng Hu, Claudia Nastasi, Lise M Lindahl, Terkild B Buus, Thorbjørn Krejsgaard, Mariusz A Wasik, Katharina L Kopp, Sergei B Koralov, Jenny L Persson, Charlotte M Bonefeld, Carsten Geisler, Anders Woetmann, Lars Iversen, Jurgen C Becker, Niels Odum
Deficient expression of Suppressor Special AT-rich Binding-1 (SATB1) hampers thymocyte development and results in inept T cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequent variant of cutaneous T cell lymphoma (CTCL). Here we report on a disease-stage-associated decrease of SATB1 expression and an inverse expression of STAT5 and SATB1 in situ. Importantly, STAT5 inhibited SATB1 expression through induction of miR-155. Decreased SATB1 expression triggered enhanced expression of IL-5 and IL-9 (but not IL-6 and IL-32) whereas increased SATB1 expression had the opposite effect indicating that the mir-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells...
May 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29751002/adam17-deficient-mice-model-the-transcriptional-signature-of-human-atopic-dermatitis
#16
Therese Woodring, Tetsuro Kobayashi, Doyoung Kim, Keisuke Nagao
No abstract text is available yet for this article.
May 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29751001/ixekizumab-pharmacokinetics-anti-drug-antibodies-and-efficacy-through-60-weeks-of-treatment-of-moderate-to-severe-plaque-psoriasis
#17
Kristian Reich, Kimberley Jackson, Susan Ball, Sandra Garces, Lisa Kerr, Laiyi Chua, Talia M Muram, Andrew Blauvelt
Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A, is efficacious for moderate-to-severe plaque psoriasis. We examined relationships between serum ixekizumab concentrations, treatment-emergent anti-drug antibodies (TE-ADA), and efficacy during 60 weeks of treatment in a randomized, controlled, phase 3 study. Steady-state ixekizumab serum trough concentrations were rapidly achieved and associated with high clinical responses at week 12 with a starting dose of 160 mg followed by 80 mg every 2 weeks...
May 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29733814/physician-skin-checks-before-the-diagnosis-of-melanoma-correlate-with-tumor-characteristics
#18
Catherine M Olsen, Nirmala Pandeya, Bridie S Thompson, Jean Claude Dusingize, Adele C Green, Rachel E Neale, David C Whiteman
No abstract text is available yet for this article.
May 4, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29730335/the-stenosis-of-cerebral-arteries-and-impaired-brain-glucose-uptake-by-long-lasting-inflammatory-cytokine-release-from-dermatitis-but-rescued-by-anti-il-1-therapy
#19
Shinya Kato, Yoshiaki Matsushima, Kento Mizutani, Fumihiro Kawakita, Masashi Fujimoto, Karin Okada, Makoto Kondo, Koji Habe, Hidenori Suzuki, Hitoshi Mizutani, Keiichi Yamanaka
No abstract text is available yet for this article.
May 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29730334/fractional-sunburn-threshold-uvr-doses-generate-equivalent-vitamin-d-and-dna-damage-in-skin-types-i-vi-but-with-epidermal-dna-damage-gradient-correlated-to-skin-darkness
#20
Barbara B Shih, Mark D Farrar, Marcus S Cooke, Joanne Osman, Abigail K Langton, Richard Kift, Ann R Webb, Jacqueline L Berry, Rachel E B Watson, Andy Vail, Frank R de Gruijl, Lesley E Rhodes
Public health guidance recommends limiting sun-exposure to sub-sunburn levels, but it's unknown whether these can gain vitamin D (for musculoskeletal health) whilst avoiding epidermal DNA damage (initiates skin cancer). Well-characterised healthy humans of all skin types (I-VI; lightest to darkest skin) were exposed to a low dose-series of solar simulated UVR of 20-80% their individual sunburn threshold dose (minimal erythemal dose, MED). Significant UVR dose-responses were seen for serum 25(OH)D and whole epidermal CPD, with as little as 0...
May 3, 2018: Journal of Investigative Dermatology
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