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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/29331523/negative-evidence-of-direct-differentiation-from-bone-marrow-cells-to-keratinocytes-in-normal-and-wounded-skin-using-keratin-5-specific-reporter-mice
#1
Gyohei Egawa, Kenji Kabashima
No abstract text is available yet for this article.
January 10, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29317265/wound-regeneration-deficit-in-rats-correlates-with-low-morphogenetic-potential-and-distinct-transcriptome-profile-of-epidermis
#2
Christian F Guerrero-Juarez, Aliaksandr A Astrowski, Rabi Murad, Christina T Dang, Vera O Shatrova, Aksana Astrowskaja, Chae Ho Lim, Raul Ramos, Xiaojie Wang, Yuchen Liu, Hye-Lim Lee, Kim T Pham, Tsai-Ching Hsi, Ji Won Oh, Daniel Crocker, Ali Mortazavi, Mayumi Ito, Maksim V Plikus
Large excisional wounds in mice prominently regenerate new hair follicles (HFs) and fat, yet humans are deficient for this regenerative behavior. Currently, wound-induced regeneration remains a clinically desirable, but only partially understood phenomenon. We show that large excisional wounds in rats, across seven strains fail to regenerate new HFs. We compared wound transcriptomes between mice and rats at the time of scab detachment, which coincides with the onset of HF regeneration in mice. In both species, wound dermis and epidermis share core dermal and epidermal transcriptional programs respectively, yet prominent inter-species differences exist...
January 6, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29317264/the-genetics-of-chronic-itch-gene-expression-in-the-skin-of-atopic-dermatitis-and-psoriasis-patients-with-severe-itch
#3
Leigh A Nattkemper, Hong Liang Tey, Rodrigo Valdes-Rodriguez, Helen Lee, Nicholas K Mollanazar, Christian Albornoz, Kristen M Sanders, Gil Yosipovitch
To identify itch-related mediators and receptors that are differentially expressed in pruritic skin, we used RNA sequencing to analyze the complete transcriptome in skin from paired itchy, lesional and non-itchy, non-lesional skin biopsies from 25 atopic dermatitis (AD) and 25 psoriasis patients and site-matched biopsies from 30 healthy controls. This analysis identified 18,000 differentially expressed genes common between itchy atopic and psoriatic skin compared to healthy skin. Of those, almost 2,000 genes were differentially expressed between itchy and non-itchy skin in atopic and psoriatic subjects...
January 6, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29317263/keratinocyte-specific-ablation-of-ripk4-allows-epidermal-cornification-but-impairs-skin-barrier-formation
#4
Corinne Urwyler-Rösselet, Giel Tanghe, Kirsten Leurs, Barbara Gilbert, Riet De Rycke, Michiel De Bruyne, Saskia Lippens, Sonja Bartunkova, Philippe De Groote, Carine Niessen, Marek Haftek, Peter Vandenabeele, Wim Declercq
In humans, RIPK4 mutations can lead to the autosomal recessive Bartsocas-Papas and popliteal pterygium syndromes, which are characterized by severe skin defects, pterygia as well as clefting. We show here that the epithelial fusions observed in RIPK4 full KO mice are E-cadherin dependent, as keratinocyte-specific deletion of E-cadherin in RIPK4 full KO mice rescued the tail-to-body fusion and fusion of oral epithelia. To elucidate RIPK4 function in epidermal differentiation and development we generated epidermis-specific RIPK4 knockout mice (RIPK4EKO)...
January 6, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29307594/expression-of-pi3k-signalling-associated-with-t-cells-in-psoriasis-is-inhibited-by-seletalisib-a-pi3k%C3%AE-inhibitor-and-is-required-for-functional-activity
#5
Nicole Yager, Ciara Haddadeen, Mark Powell, Andrew Payne, Rodger Allen, Eugene Healy
No abstract text is available yet for this article.
January 4, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29291383/genetic-profiles-of-squamous-cell-carcinomas-associated-with-recessive-dystrophic-epidermolysis-bullosa-unveil-notch-and-tp53-mutations-and-an-increased-myc-expression
#6
L Sans-DeSanNicolas, G Caratú, O Vidal-Cortés, S Sanchez-Redondo, B Ferrer, F Mancuso, E González-Sanchez, M Pérez-Alea, K McGrail, J Hernandez-Losa, D Bodet, A Vivancos, V Garcia-Patos, J A Recio
No abstract text is available yet for this article.
December 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29291382/t-cells-dominate-the-local-immune-response-induced-by-intralesional-il-2-in-combination-with-imiquimod-and-retinoid-for-in-transit-metastatic-melanoma
#7
Hiromi Ogawa, Guillaume Luxardi, Amanda Kirane, Rajan Kulkarni, Arta M Monjazeb, Michelle Y Cheng, Chelsea Ma, Emanual Maverakis
No abstract text is available yet for this article.
December 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29288652/co-activation-of-gr-and-ppar%C3%AE-in-murine-skin-prevents-worsening-of-atopic-march
#8
Julie Deckers, Nadia Bougarne, Viacheslav Mylka, Sofie Desmet, Astrid Luypaert, Michael Devos, Giel Tanghe, Justine Van Moorleghem, Manon Vanheerswynghels, Lode De Cauwer, Jonathan Thommis, Marnik Vuylsteke, Jan Tavernier, Bart Lambrecht, Hamida Hammad, Karolien De Bosscher
Children with atopic dermatitis (AD) show an increased risk to develop asthma later in life, a phenomenon referred to as 'atopic march', which emphasizes the need for secondary prevention therapies. This study aimed to investigate whether relief of skin inflammation by glucocorticoids and PPARγ-agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite (HDM) via the skin, followed by exposure to HDM in lungs...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29288651/unopposed-il-36-activity-promotes-clonal-cd4-t-cell-responses-with-il-17a-production-in-generalized-pustular-psoriasis
#9
Akiko Arakawa, Sigrid Vollmer, Petra Besgen, Adrian Galinski, Burkhard Summer, Yoshio Kawakami, Andreas Wollenberg, Klaus Dornmair, Michael Spannagl, Thomas Ruzicka, Peter Thomas, Jörg C Prinz
Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory aetiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signalling promotes antigen-driven and likely pathogenic T-helper 17 (Th17) responses in GPP. We observed that CD4+ T cells in blood and skin lesions of GPP patients were characterized by intense hyperproliferation, production of the GPP key mediator, IL-17A, and highly restricted T-cell receptor (TCR) repertoires with identical T-cell clones in blood and skin lesions indicating antigen-driven T-cell expansions...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29288650/cooling-relief-of-acute-and-chronic-itch-requires-trpm8-channels-and-neurons
#10
Radhika Palkar, Serra Ongun, Edward Catich, Natalie Li, Neil Borad, Angela Sarkisian, David D McKemy
Cooling or the application of mentholated liniments to the skin has been used to treat itch for centuries, yet remarkably little is known of how counter-stimuli such as these induce itch relief. Indeed, there is no clear consensus in the scientific literature as to whether or not cooling does in fact block the transduction of itch signals or if it is simply a placebo effect. This gap in our understanding led us to hypothesize that cooling is antipruritic and, like cooling analgesia, requires function of the cold-gated ion channel TRPM8, a receptor for menthol expressed on peripheral afferent nerve endings...
December 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29287763/topically-applied-nicotinamide-inhibits-human-hair-follicle-growth-ex-vivo
#11
Iain S Haslam, Jonathan A Hardman, Ralf Paus
No abstract text is available yet for this article.
December 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29287762/the-p38-mitogen-activated-protein-kinase-critically-regulates-human-keratinocyte-inflammasome-activation
#12
Gabriele Fenini, Serena Grossi, Samuel Gehrke, Hans-Dietmar Beer, Takashi R Satoh, Emmanuel Contassot, Lars E French
Inflammasomes are key intracellular signaling platforms involved in innate immune responses to microorganisms and danger signals. Extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members are activated by numerous environmental stresses. Recently, it has been reported that JNK is involved in inflammasome activation in myeloid immune cells. To date, the role of MAPK in inflammasome activity in keratinocytes has not been investigated...
December 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29277541/hpv16e7-induced-hyperplasia-promotes-cxcl9-10-expression-and-induces-cxcr3-t-cell-migration-to-skin
#13
Paula Kuo, Zewen K Tuong, Siok Min Teoh, Ian H Frazer, Stephen Mattarollo, Graham R Leggatt
Chemokines regulate tissue immunity by recruiting specific subsets of immune cells. Mice expressing the E7 protein of HPV16 as a transgene from a keratin 14 promoter (K14.E7) show increased epidermal and dermal lymphocytic infiltrates, epidermal hyperplasia and suppressed local immunity. Here, we show that CXCL9 and CXCL10 are overexpressed in non-haematopoietic cells in skin of K14.E7 mice when compared with non-transgenic animals, and recruit CXCR3+ lymphocytes to the hyperplastic skin. Overexpression of CXCL9 and CXCL10 is not observed in E7 transgenic mice with mutated Rb gene whose protein product cannot interact with E7 (K14...
December 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29277540/claudin-3-loss-causes-leakage-of-sweat-from-the-sweat-gland-to-contribute-to-the-pathogenesis-of-atopic-dermatitis
#14
Kosuke Yamaga, Hiroyuki Murota, Atsushi Tamura, Hirofumi Miyata, Masato Ohmi, Junichi Kikuta, Masaru Ishii, Sachiko Tsukita, Ichiro Katayama
The transfer of sweat to the skin surface without leakage is important for the homeostatic regulation of skin and is impaired in atopic dermatitis (AD). Although the precise composition of the leakage barrier remains obscure, there is a large contribution from claudins, the major components of tight junctions. In humans, claudin-1, -3, and -15 are expressed on sweat ducts, and claudin-3 and -10 are expressed on secretory coils. Although only two claudins are expressed in murine sweat glands, we found that the expression of claudin-3 is conserved...
December 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29277539/skin-wound-healing-is-accelerated-by-a-lipid-mixture-representing-major-lipid-components-of-chamaecyparis-obtusa-plant-extract
#15
Byung Eui Kim, Elena Goleva, Clifton F Hall, Sang Hyun Park, Un Ha Lee, Anne M Brauweiler, Joanne E Streib, Brittany N Richers, Gwuicheol Kim, Donald Y M Leung
In chronic non-healing wounds, the healing process is disrupted and wounds are often infected with bacteria. About 85% of lower extremity amputations in diabetes are attributed to deep infection of foot ulcers. Therefore, infection control is critical for wound care. In this study, we analyzed lipid composition of Chamaecyparis (C) obtusa extract, and describe the wound healing properties of its combination of ten major lipid components. A 10 lipid mixture upregulated HBD-3 and LL-37 through the olfactory receptor 2AT4, and induced phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases in primary human keratinocytes...
December 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29277538/sexual-dimorphism-in-response-to-a-nrf2-inducer-in-a-model-for-pachyonychia-congenita
#16
Michelle L Kerns, Jill M C Hakim, Abigail Zieman, Rosemary G Lu, Pierre A Coulombe
Sex is an influential factor regarding pathophysiology and therapeutic response in human disease. Pachyonychia congenita (PC) is caused by mutations in keratin genes and typified by dystrophic lesions affecting nails, glands, oral mucosa, and palmar-plantar epidermis. Painful palmar-plantar keratoderma (PPK) severely impair mobility in PC. Mice genetically null for keratin 16 (Krt16), one of the genes mutated in PC, develop PC-like PPK. In male Krt16-/- mice, oxidative stress associated with impaired glutathione synthesis and NRF2-dependent gene expression precedes PPK onset, which can be prevented by topical sulforaphane (SF)-mediated activation of NRF2 (Kerns et al...
December 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29277537/transcriptomic-analysis-of-two-cdsn-deficient-mice-reveals-gene-signatures-biologically-relevant-for-peeling-skin-disease
#17
Sarra Zaafouri, Mélanie Pichery, Anne Huchenq, Frederic Valentin, Vinzenz Oji, Juliette Mazereeuw-Hautier, Guy Serre, Nathalie Jonca
No abstract text is available yet for this article.
December 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29273315/staphylococcus-aureus-triggers-induction-of-mir-15b-5p-to-diminish-dna-repair-and-de-regulate-inflammatory-response-in-diabetic-foot-ulcers
#18
Horacio A Ramirez, Irena Pastar, Ivan Jozic, Olivera Stojadinovic, Rivka C Stone, Nkemcho Ojeh, Joel Gil, Stephen C Davis, Robert S Kirsner, Marjana Tomic-Canic
Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial presence, including its frequent colonizer Staphylococcus aureus, contribute to inhibition of healing. MicroRNAs (miRs) play a role in healing and host response to bacterial pathogens. However, the mechanisms by which miR response to cutaneous S. aureus contributes to DFU pathophysiology are unknown. Herein we show S. aureus inhibits wound closure and induces miR-15b-5p in acute human and porcine wound models, and in chronic DFUs...
December 19, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29273314/antibiotic-drug-use-and-the-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-population-based-case-control-study
#19
Noel Frey, Andreas Bircher, Michael Bodmer, Susan S Jick, Christoph R Meier, Julia Spoendlin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous adverse drug reactions. Sulphonamide antibiotics are commonly accepted as one of the primary causes of SJS/TEN. This notion is based on results from two hospital-based case-control studies that identified the combined antibiotic cotrimoxazole (sulfamethoxazole and trimethoprim) as the cause of several SJS/TEN cases. Associations were also reported for penicillins, quinolones, cephalosporins, macrolides, tetracyclines, and metronidazole...
December 19, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29258894/the-conundrum-of-allogeneic-bone-marrow-transplantation-for-epidermolysis-bullosa
#20
Jouni Uitto
Epidermolysis bullosa (EB) is a heterogeneous group of heritable blistering disorders with considerable morbidity and mortality. Currently, there is no effective treatment or cure for EB, but bone marrow transplantation (BMT) has been suggested to improve the clinical presentation and quality of life in some patients with the recessive dystrophic subtype of EB. In this issue, Hünefeld et al. (pp.000) address the issue whether BMT could be applied to patients with EB simplex with intra-epidermal blistering...
December 16, 2017: Journal of Investigative Dermatology
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