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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/28927893/msx1-induced-neural-crest-like-reprogramming-promotes-melanoma-progression
#1
Markus V Heppt, Joshua X Wang, Denitsa M Hristova, Zhi Wei, Ling Li, Brianna Evans, Marilda Beqiri, Samir Zaman, Jie Zhang, Martin Irmler, Carola Berking, Robert Besch, Johannes Beckers, Frank J Rauscher, Rick A Sturm, David E Fisher, Meenhard Herlyn, Mizuho Fukunaga-Kalabis
Melanoma cells share many biological properties with neural crest stem cells. Here we show that the homeodomain transcription factor Msh homeobox 1 (MSX1), which is significantly correlated with melanoma disease progression, reprograms melanocytes and melanoma cells towards a neural crest precursor-like state. MSX1-reprogrammed normal human melanocytes express the neural crest marker p75 and become multipotent. MSX1 induces a phenotypic switch in melanoma, which is characterized by an oncogenic transition from an E-cadherin-high non-migratory state towards a ZEB1-high invasive state...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927892/cd100-plexin-b2-promotes-the-inflammation-in-psoriasis-by-activating-nf-%C3%AE%C2%BAb-and-inflammasome-in-keratinocytes
#2
Chen Zhang, Chunying Xiao, Erle Dang, Jiao Cao, Zhenlai Zhu, Meng Fu, Xu Yao, Yufeng Liu, Boquan Jin, Gang Wang, Wei Li
Plexin-B2 (PlxnB2) and its ligand, CD100 (Semaphorin 4D), are originally identified as axon-guidance molecules that function during neuronal development; however, studies also showed that CD100-Plexins participate in various immune responses. In the present study, we found that the expression of PlxnB2 on keratinocytes was specifically increased in lesional skin of psoriasis patients, but not atopic dermatitis. Levels of soluble CD100 (sCD100) and membrane CD100 (mCD100) were elevated in sera of psoriasis patients and on keratinocytes of psoriatic skin, respectively...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927891/vitiligo-skin-is-imprinted-with-resident-memory-cd8-t-cells-expressing-cxcr3
#3
Katia Boniface, Clément Jacquemin, Anne-Sophie Darrigade, Benoît Dessarthe, Christina Martins, Nesrine Boukhedouni, Charlotte Vernisse, Alexis Grasseau, Denis Thiolat, Jérôme Rambert, Fabienne Lucchese, Antoine Bertolotti, Khaled Ezzedine, Alain Taieb, Julien Seneschal
Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM). We sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared to psoriasis and control unaffected skin...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927890/reduction-of-inflammatory-and-cardiovascular-proteins-in-the-blood-of-psoriasis-patients-differential-responses-between-tofacitinib-and-etanercept-after-4-weeks-of-treatment
#4
Jaehwan Kim, Lewis Tomalin, Julie Lee, Lori J Fitz, Gabriel Berstein, Joel Correa-da Rosa, Sandra Garcet, Michelle A Lowes, Hernan Valdez, Robert Wolk, Mayte Suarez-Farinas, James G Krueger
Psoriasis patients have increased risk of myocardial infarction, and psoriasis is now recognized as an independent risk factor for coronary heart disease and cardiovascular mortality. To understand the effects of psoriasis medications on systemic inflammation associated with cardiovascular risks, we studied blood proteins related to inflammation and cardiovascular disease archived from a phase 3 clinical trial of tofacitinib and etanercept in adults with moderate-to-severe psoriasis. 157 blood proteins were quantified by a proximity extension assay from 266 patients at baseline and week 4...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927889/epidemiology-of-eczema-herpeticum-in-hospitalized-us-children-analysis-of-a-nationwide-cohort
#5
Derek Y Hsu, Kanade Shinkai, Jonathan I Silverberg
Eczema herpeticum (EH) is characterized by viral infection of a preexisting inflammatory dermatosis and is associated with considerable morbidity. In this cross-sectional study, we sought to determine the incidence, risk factors, comorbidities, costs of care, length of stay, and mortality in hospitalized US children with EH. The Nationwide Inpatient Sample 2002-2012, containing a 20% sample of all US hospitalizations, was analyzed. We used a validated approach involving ICD-9-CM codes to identify patients primarily admitted for EH (n=4655 weighted)...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927887/epidermal-overexpression-of-xenobiotic-receptor-pxr-impairs-the-epidermal-barrier-and-triggers-th2-immune-response
#6
Andreas Elentner, Matthias Schmuth, Nikolaos Yannoutsos, Thomas O Eichmann, Robert Gruber, Franz Pw Radner, Martin Hermann, Barbara Del Frari, Sandrine Dubrac
The skin is in daily contact with environmental pollutants, but the long-term effects of such exposure remain under-investigated. Many of these toxins bind and activate the pregnane x receptor (PXR), a ligand-activated transcription factor that regulates genes central to xenobiotic metabolism. The objective of this work was to investigate the effect of constitutive activation of PXR in the basal layer of the skin to mimic repeated skin exposure to noxious molecules. We designed a transgenic mouse model which overexpresses the human PXR gene linked to the herpes simplex VP16 domain under the control of the keratin 14 promoter...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28923241/opposing-roles-of-epidermal-integrins-%C3%AE-3%C3%AE-1-and-%C3%AE-9%C3%AE-1-in-regulation-of-mtld-bmp-1-mediated-laminin-%C3%AE-2-processing-during-wound-healing
#7
Whitney M Longmate, Scott P Lyons, Lori DeFreest, Livingston Van De Water, C Michael DiPersio
Proteolytic processing of the laminin-γ2 chain is a hallmark of basement membrane maturation in the skin. Integrin α3β1, a major receptor for epidermal adhesion to laminin-332, is critical for proper basement membrane organization during skin development and wound healing. Previously, we identified a role for α3β1 in promoting the processing of laminin-γ2 in cultured keratinocytes in vitro and in wound epidermis in vivo. In the current study we identify the Bmp1 gene, which encodes variants of the mammalian tolloid/bone morphogenetic protein-1 metalloproteases, as a critical regulator of α3β1-dependent laminin-γ2 processing, thereby expanding the role of this integrin in controlling the secretion by the epidermis of factors that modulate the tissue microenvironment...
September 15, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927888/the-effect-of-water-hardness-on-surfactant-deposition-following-washing-and-subsequent-skin-irritation-in-atopic-dermatitis-patients-and-healthy-controls
#8
Simon G Danby, Kirsty Brown, Andrew M Wigley, John Chittock, Phyoe K Pyae, Carsten Flohr, Michael J Cork
Living in a hard water area is associated with an increased risk of atopic dermatitis (AD). Greater skin barrier impairment following exposure to surfactants in wash products combined with high calcium, and/or chlorine, levels in hard water is a compelling mechanism for this increase. The purpose of this study was to investigate this mechanism in individuals with and without a predisposition to skin barrier impairment. We recruited 80 subjects; healthy controls and AD patients with and without FLG mutations...
September 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899689/enhanced-expression-of-genes-related-to-xenobiotic-metabolism-in-the-skin-of-patients-with-atopic-dermatitis-but-not-with-ichthyosis-vulgaris
#9
Stefan Blunder, Sulev Kõks, Gea Kõks, Ene Reimann, Hubert Hackl, Robert Gruber, Verena Moosbrugger-Martinz, Matthias Schmuth, Sandrine Dubrac
Previous transcriptome analyses underscored the importance of immunological and skin barrier abnormalities in atopic dermatitis (AD). We sought to identify novel pathogenic pathways involved in AD by comparing the transcriptomes of AD patients stratified for filaggrin (FLG) null mutations to those of both healthy donors and patients with ichthyosis vulgaris (IV). We applied RNA-sequencing to analyze the whole transcriptome of nonlesional skin. Six-hundred and seven genes (476 up-regulated and 131 down-regulated by greater than 2-fold) and one-hundred and ninety-three genes (172 up-regulated and 21 down-regulated by greater than 2-fold) were differentially expressed when all AD or IV patients were compared to healthy donors, respectively...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899688/keratins-regulate-the-adhesive-properties-of-desmosomal-cadherins-through-signaling
#10
Franziska Vielmuth, Marie-Therès Wanuske, Mariya Y Radeva, Matthias Hiermaier, Daniela Kugelmann, Elias Walter, Fanny Buechau, Thomas M Magin, Jens Waschke, Volker Spindler
Tightly controlled intercellular adhesion is crucial for integrity and function of the epidermis. The keratin filament cytoskeleton anchors desmosomes, supramolecular complexes required for strong intercellular adhesion. We here tested whether keratin filaments control cell adhesion by regulating the adhesive properties of desmosomal cadherins such as desmoglein (Dsg) 3. Atomic force microscopy (AFM) and FRAP experiments revealed reduced Dsg3 adhesive forces and membrane stability in murine keratinocytes lacking all keratin filaments...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899687/proteomic-profiling-of-sweat-exosome-suggests-its-involvement-in-skin-immunity
#11
Chang-Xian Wu, Zheng-Fei Liu
The healthy human skin sustains an effective immune defense mechanism, formed by a complex physical and chemical epidermal barrier that coordinates with different cellular components of the skin immune system. However, the mechanism how skin cells regulate local immune homeostasis in health and disease contexts is not well known. To investigate whether exosomes exist in sweat, sweat samples from healthy individuals were collected after aerobic exercise. Sweat exosome was isolated via differential ultracentrifugation, observed under transmission electron microscope, measured by dynamic light scattering and confirmed by immunoblot...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899686/the-anti-c1s-antibody-tnt003-prevents-complement-activation-in-the-skin-induced-by-bullous-pemphigoid-autoantibodies
#12
Anika Kasprick, Maike M Holtsche, Eileen L Rose, Sami Hussain, Enno Schmidt, Frank Petersen, Sandip Panicker, Ralf J Ludwig
No abstract text is available yet for this article.
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899685/the-tumor-promoting-role-of-trip4-in-melanoma-progression-and-its-involvement-in-response-to-braf-targeted-therapy
#13
Jiaojiao Hao, Hua Xu, Meihua Luo, Wendan Yu, Miao Chen, Yina Liao, Changlin Zhang, Xinrui Zhao, Wei Jiang, Shuai Hou, Xu Feng, Kun Zou, Yiming Chen, Wenlin Huang, Wei Guo, Lan Kang, Wuguo Deng
Thyroid Hormone Receptor Interactor 4 (TRIP4) was identified with anti-proliferative effect in melanoma cells based on siRNA library screening, however, its precise function in melanoma progression is completely unknown. Here, we explored the carcinogenic role of TRIP4 in melanoma. The high expression of TRIP4 was observed in human melanoma cells and tissues. Its knockdown suppressed melanoma progression in vitro and in vivo, including melanoma cell proliferation, migration and invasion inhibition, and apoptosis induction...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899684/glycoprotein-non-melanoma-clone-b-regulates-the-crosstalk-between-macrophages-and-mesenchymal-stem-cells-towards-wound-repair
#14
Bing Yu, Talib Alboslemy, Fayez Safadi, Min-Ho Kim
The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited to the site of injury, where they participate in the repair process. Despite considerable understanding on the role of each cell type in the process of wound repair, the nature of the dynamic interplay between these two cell types and how this interaction influences the process of wound repair are not well understood...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899683/a-missense-mutation-within-the-helix-termination-motif-of-krt25-causes-autosomal-dominant-woolly-hair-hypotrichosis
#15
Xia Yu, Fuyin Chen, Cheng Ni, Guolong Zhang, Luyao Zheng, Jia Zhang, Chengrang Li, Sandilands A, Zhirong Yao, Ming Li
No abstract text is available yet for this article.
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899682/caveolin-1-controls-hyperresponsiveness-to-mechanical-stimuli-and-fibrogenesis-associated-runx2-activation-in-keloid-fibroblasts
#16
Chao-Kai Hsu, Hsi-Hui Lin, Hans I-Chen Harn, Rei Ogawa, Yang-Kao Wang, Yen-Ting Ho, Wan-Rung Chen, Yi-Chao Lee, Julia Yu-Yun Lee, Shyh-Jou Shieh, Chao-Min Cheng, John A McGrath, Ming-Jer Tang
Keloids are pathological scars characterized by excessive extracellular matrix production that are prone to form in body sites with increased skin tension. Caveolin-1 (CAV1), the principal coat protein of caveolae, has been associated with the regulation of cell mechanics, including cell softening and loss of stiffness sensing ability in NIH3T3 fibroblasts. Although CAV1 is present in low amounts in keloid fibroblasts (KFs), the causal association between CAV1 downregulation and its aberrant responses to mechanical stimuli remain unclear...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899681/comparative-degradomics-of-porcine-and-human-wound-exudates-unravels-biomarker-candidates-for-assessment-of-wound-healing-progression-in-trauma-patients
#17
Fabio Sabino, Fabian E Egli, Simonas Savickas, Jörg Holstein, Daniela Kaspar, Mika Rollmann, Jayachandran N Kizhakkedathu, Tim Pohlemann, Hans Smola, Ulrich Auf dem Keller
Impaired cutaneous wound healing is a major complication in elderly people and patients suffering from diabetes with raising rates in industrialized countries. Heterogeneity of clinical manifestations hampers effective molecular diagnostics and decisions for appropriate therapeutic regimens. Using a customized positional quantitative proteomics workflow, we have established a time-resolved proteome and N-terminome resource from wound exudates in a clinically relevant pig wound model that we exploited as robust template to interpret a heterogeneous dataset from patients undergoing the same wound treatment...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28887108/new-approach-for-the-derivation-of-melanocytes-from-induced-pluripotent-stem-ips-cells
#18
Tamihiro Kawakami, Tatsuro Okano, Sora Takeuchi, Kayoko Osumi, Yoshinao Soma, Munenari Itoh, Tomohisa Hirobe, Kowichi Jimbow
Induced pluripotent stem (iPS) cells have the ability to differentiate into multiple cell types in the body and have an unlimited growth potential. However, iPS cell-derived melanocytes produced by existing protocols have significant limitations in developing novel strategies for regenerative medicine and cell therapies of pigmentation disorders in humans, because they involve culture in media containing fetal bovine serum (FBS) and non-physiologic agents. In this study, we established a new in vitro approach to generate iPS cell-derived human melanocytes which have higher proliferation rates and increased melanin production compared to melanocytes prepared by previously reported approaches...
September 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28887107/efficacy-of-systemic-treatments-of-psoriasis-on-pruritus-a-systemic-literature-review-and-meta-analysis
#19
Chloé Théréné, Emilie Brenaut, Thomas Barnetche, Laurent Misery
In the course of the last 30 years, several studies have clearly documented that pruritus is a very frequent symptom of psoriasis and its impact on the patients' quality of life. The variety of available systemic treatments for psoriasis is increasing rapidly. Our objective was to assess their efficacy on pruritus based on a systematic literature review. A systematic literature search was performed using PubMed and Trip Database (from January 1990 to September 2016) to find published clinical trials for the treatments of psoriasis, then a meta-analysis was performed...
September 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28870694/embryonic-fate-mapping-uncovers-the-critical-role-of-micrornas-in-the-development-of-epidermal-%C3%AE-%C3%AE-t-cells
#20
Yi Yao, Queping Liu, Carly Martin, Congcong Yin, Zheng Dong, Qing-Sheng Mi, Li Zhou
No abstract text is available yet for this article.
September 1, 2017: Journal of Investigative Dermatology
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