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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/28219661/protective-effects-of-topical-vitamin-c-compound-mixtures-against-ozone-induced-damage-in-human-skin
#1
Giuseppe Valacchi, Alessandra Pecorelli, Giuseppe Belmonte, Erika Pambianchi, Franco Cervellati, Stephen Lynch, Yevgeniy Krol, Christian Oresajo
No abstract text is available yet for this article.
February 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28212813/pigmentation-traits-sun-exposure-and-risk-of-incident-vitiligo-in-women
#2
Rachel Dunlap, Shaowei Wu, Erin Wilmer, Eunyoung Cho, Wen-Qing Li, Newsha Lajevardi, Abrar Qureshi
Vitiligo is the most common cutaneous depigmentation disorder worldwide, yet little is known about specific risk factors for disease development. Utilizing data from the Nurses' Health Study (NHS), a prospective cohort study of 51,337 white women, we examined the associations between (1) pigmentary traits and (2) reactions to sun exposure and risk of incident vitiligo. NHS participants responded to a question about clinician-diagnosed vitiligo and year of diagnosis (2001 or before, 2002-2005, 2006-2009, 2010-2011, or 2012+)...
February 14, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28212812/s100b-is-a-potential-disease-activity-marker-in-non-segmental-vitiligo
#3
Reinhart Speeckaert, Sofie Voet, Esther Hoste, Nanja van Geel
Vitiligo is a chronic skin condition characterized by progressive depigmentation of the skin. S100B is a damage-associated molecular pattern (DAMP) protein expressed in melanocytes, which has been proposed as a marker of melanocyte cytotoxicity. While the use of S100B as a biomarker in melanoma is well established, its association with vitiligo activity has not yet been investigated. Here, we show that S100B serum levels were significantly increased in patients with active non-segmental vitiligo and strongly correlated with the affected body surface area...
February 14, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28202403/increased-risk-of-cutaneous-and-systemic-infections-in-atopic-dermatitis-a-cohort-study
#4
Sinéad M Langan, Katrina Abuabara, Sarah E Henrickson, Ole Hoffstad, David J Margolis
No abstract text is available yet for this article.
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28202402/low-maternal-prenatal-25-hydroxy-vitamin-d-blood-levels-are-associated-with-childhood-atopic-dermatitis
#5
Maria Blomberg, Sheryl L Rifas-Shiman, Carlos A Camargo, Diane R Gold, Maryam M Asgari, Jacob P Thyssen, Augusto A Litonjua, Matthew W Gillman, Emily Oken
No abstract text is available yet for this article.
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28202401/effect-of-body-site-and-surface-on-vitamin-d-and-25-hydroxyvitamin-d-production-after-a-single-narrowband-uvb-exposure
#6
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
No abstract text is available yet for this article.
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28202400/protective-role-of-mitochondrial-peroxiredoxin-iii-against-uvb-induced-apoptosis-of-epidermal-keratinocytes
#7
Jin Young Baek, Sujin Park, Jiyoung Park, Ji Yong Jang, Su Bin Wang, Sin Ri Kim, Hyun Ae Woo, Kyung Min Lim, Tong-Shin Chang
Ultraviolet B (UVB) light induces generation of reactive oxygen species (ROS), ultimately leading to skin cell damage. Mitochondria are a major source of ROS in UVB-irradiated skin cells, with increased levels of mitochondrial ROS having been implicated in keratinocyte apoptosis. Peroxiredoxin III (PrxIII) is the most abundant and potent H2O2-removing enzyme in the mitochondria of most cell types. Here, the protective role of PrxIII against UVB-induced apoptosis of epidermal keratinocytes was investigated. Mitochondrial H2O2 levels were differentiated from other types of ROS using mitochondria-specific fluorescent H2O2 indicators...
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28202399/the-epidemiology-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-the-uk
#8
Noel Frey, Janine Jossi, Michael Bodmer, Andreas Bircher, Susan S Jick, Christoph R Meier, Julia Spoendlin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening mucocutaneous diseases. SJS/TEN mostly manifest as a reaction to new drug use, but little is known about their incidence and epidemiology. We conducted a large observational study on the epidemiology of SJS/TEN using data from the UK-based Clinical Practice Research Datalink. Among 551 validated SJS/TEN cases, we calculated an incidence rate of 5.76 SJS/TEN cases/million person-years between 1995 and 2013, which was consistent throughout the study period, and was highest in patients aged 1-10 years and ≥80 years...
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28189536/optimizing-clinical-trials-for-atopic-dermatitis-in-children
#9
Elaine C Siegfried, Jennifer C Jaworski, Lawrence F Eichenfield, Adelaide A Hebert, Amy S Paller
No abstract text is available yet for this article.
February 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28188776/aurora-a-overexpression-aurka-is-driven-by-foxm1-and-mapk-erk-activation-in-melanoma-cells-harbouring-braf-or-nras-mutations-impact-on-melanoma-prognosis-and-therapy
#10
Joan Anton Puig-Butille, Antònia Vinyals, Josep R Ferreres, Paula Aguilera, Eduard Cabré, Gemma Tell-Martí, Joaquim Marcoval, Francesca Mateo, Luís Palomero, Celia Badenas, Josep M Piulats, Josep Malvehy, Miquel A Pujana, Susana Puig, Àngels Fabra
The cell cycle-related genes AURORA A and Forkhead box M1 (FOXM1) are overexpressed in melanoma. We show here that AURKA overexpression is associated with poor prognosis in three independent cohorts of melanoma patients and correlates with the presence of genomic amplification of AURKA locus and BRAF(V600E) mutation. AURKA overexpression may also be driven to increased promoter activation through elements such as ETS and FOXM1 found within the 5' proximal promoter region. Activated MAPK-ERK signalling pathway mediates robust AURKA promoter activation, thereby knockdown of BRAF(V600E) and ERK inhibition results in reduced AURKA transcription and expression...
February 7, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28174051/simvastatin-protects-human-melanocytes-from-h2o2-induced-oxidative-stress-by-activating-nrf2
#11
Yuqian Chang, Shuli Li, Weinan Guo, Yuqi Yang, Weigang Zhang, Qian Zhang, Yuanmin He, Xiuli Yi, Tingting Cui, Yawen An, Pu Song, Zhe Jian, Ling Liu, Kai Li, Gang Wang, Tianwen Gao, Lin Wang, Chunying Li
The prevention of hydrogen peroxide (H2O2)-induced oxidative stress has been proved to be beneficial to vitiligo patients. Simvastatin possesses anti-oxidative capacity and has shown protective effect in various oxidative stress-related diseases. However, whether simvastatin can protect human melanocytes against oxidative stress has not been investigated. In the present study, we initially found that pre-treatment of 0.1 μM to 1.0 μM simvastatin led to increased cell viability and decreased cell apoptosis of melanocytes in response to H2O2...
February 4, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28163070/noninvasive-determination-of-melanoma-depth-using-a-handheld-photoacoustic-probe
#12
Yong Zhou, Shivani V Tripathi, Ilana Rosman, Jun Ma, Pengfei Hai, Gerald P Linette, M Laurin Council, Ryan C Fields, Lihong V Wang, Lynn A Cornelius
No abstract text is available yet for this article.
February 2, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28163069/adipose-derived-stem-cells-protect-skin-flaps-against-ischemia-reperfusion-injury-via-interleukin-6-expression
#13
Chi-Ming Pu, Chen-Wei Liu, Chan-Jung Liang, Yu-Hsiu Yen, Shun-Hua Chen, Ya-Fen Jiang-Shieh, Chung-Liang Chien, Ya-Chun Chen, Yuh-Lien Chen
Flap necrosis is the most frequent postoperative complication encountered in reconstructive surgery. We elucidated whether adipose-derived stem cells (ADSCs) and their derivatives might induce neovascularization and protect skin flaps during ischemia/reperfusion (I/R) injury. Flaps were subjected to 3 h of ischemia by ligating long thoracic vessels and then to blood reperfusion. Q-tracker-labeled ADSCs, conditioned media (ADSC-CM), or exosomes (ADSC-Exo) were injected into the flaps. These treatments led to significantly increase flap survival and capillary density compared to I/R on postoperative day 5...
February 2, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28163068/hyaluronic-acid-decreases-lipid-synthesis-in-sebaceous-glands
#14
Yu Ra Jung, Chul Hwang, Jeong-Min Ha, Dae-Kyoung Choi, Kyung-Cheol Sohn, Young Lee, Young-Joon Seo, Young-Ho Lee, Chang-Deok Kim, Jeung-Hoon Lee, Myung Im
Hyaluronic acid (HA) is the major glycosaminoglycan in the extracellular matrix and has been implicated in several functions in skin cells. However, evidence is lacking regarding the HA signaling in sebaceous glands, and its potential role needs to be clarified. We investigated the role of HA in lipid production in sebaceous glands in an experimental study of human sebocytes followed by a clinical study. We first examined the effects of HA on sebaceous glands in hamsters and intradermal injection of HA into hamster auricles decreased both the size of sebaceous glands and the level of lipid production...
February 2, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28163067/absence-of-the-integrin-%C3%AE-3-subunit-induces-an-activated-phenotype-in-human-keratinocytes
#15
Chiara Pazzagli, Yinghong He, Hauke Busch, Philipp Esser, Dimitra Kiritsi, Yannick Gache, Leena Bruckner-Tuderman, Melanie Boerries, Cristina Has
No abstract text is available yet for this article.
February 2, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28143781/phenformin-enhances-the-efficacy-of-erk-inhibition-in-nf1-mutant-melanoma
#16
Sebastian Trousil, Shuang Chen, Chan Mu, Fiona M Shaw, Zhan Yao, Yuping Ran, Tiwari Shakuntala, Taha Merghoub, Dieter Manstein, Neal Rosen, Lewis C Cantley, Jonathan H Zippin, Bin Zheng
Inactivation of the tumor suppressor neurofibromin 1 (NF1) presents a newly characterized melanoma subtype, for which currently no targeted therapies are clinically available. Pre-clinical studies suggest that ERK inhibitors are likely to provide benefit, albeit with limited efficacy as single agent; therefore, there is a need for rationally designed combination therapies. Here, we evaluate the combination of the ERK inhibitor SCH772984 and the biguanide phenformin. Combination of both compounds showed potent synergy in cell viability assays and cooperatively induced apoptosis...
January 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28143780/msi2-maintains-quiescent-state-of-hair-follicle-stem-cells-by-directly-repressing-the-hh-signaling-pathway
#17
Xianghui Ma, Yuhua Tian, Yongli Song, Jianyun Shi, Jiuzhi Xu, Kai Xiong, Jia Li, Wenjie Xu, Yiqiang Zhao, Jianwei Shuai, Lei Chen, Maksim V Plikus, Christopher Lengner, Fazheng Ren, Lixiang Xue, Zhengquan Yu
Hair follicles (HFs) undergo precisely regulated cycles of active regeneration consisting of (anagen), involution (catagen), and relative quiescence (telogen) phases. HF stem cells (HFSCs) play important roles in regenerative cycling. Elucidating mechanisms that governs HFSC behavior can help uncover the underlying principles of hair development, hair growth disorders and skin cancers. RNA-binding proteins of the Musashi (Msi) have been implicated in the biology of different stem cell types, yet they have not been studied in HFSCs...
January 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28132857/il-27-facilitates-skin-wound-healing-through-induction-of-epidermal-proliferation-and-host-defense
#18
Bin Yang, Jutamas Suwanpradid, Roberto Sanchez-Lagunes, Hae Woong Choi, Peter Hoang, Donghai Wang, Soman N Abraham, Amanda S MacLeod
Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the factors that trigger epithelial cell proliferation in this inflammatory process are incompletely understood. In this study, we demonstrate that IL-27 is rapidly and transiently produced by CD301b(+) cells in the skin following injury. The functional role of IL-27 and CD301b(+) cells is demonstrated by the finding that CD301b-depleted mice exhibit delayed wound closure in vivo which could be rescued by topical IL-27 treatment...
January 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28132856/nadph-oxidase-1-plays-a-key-role-in-keratinocyte-responses-to-ultraviolet-radiation-and-uvb-induced-skin-carcinogenesis
#19
Houssam Raad, Martin Serrano-Sanchez, Ghida Harfouche, Walid Mahfouf, Doriane Bortolotto, Vanessa Bergeron, Zeinab Kasraian, Lea Dousset, Mohsen Hosseini, Alain Taieb, Hamid Reza Rezvani
The NADPH oxidase (NOX) family enzymes are involved in several physiological functions. However, their roles in keratinocyte responses to ultraviolet (UV) radiation have not been clearly elucidated. This study demonstrates that, among other NOX family members, UVB irradiation results in a biphasic activation of NOX1 that plays a critical role in defining keratinocyte fate through the modulation of the DNA damage response (DDR) network. Indeed, suppression of both bursts of UVB-induced NOX1 activation by using a specific peptide inhibitor of NOX1 (InhNOX1) is associated with increased nucleotide excision repair (NER) efficiency and reduction of apoptosis, which is finally translated into decreased photocarcinogenesis...
January 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28132855/bone-marrow-derived-mesenchymal-stem-cells-expressing-thioredoxin-1-attenuate-bleomycin-induced-skin-fibrosis-and-oxidative-stress-in-scleroderma
#20
Miao Jiang, Yiwu Yu, Jingying Luo, Qingyun Gao, Lili Zhang, Qiangxiong Wang, Jingjun Zhao
Systemic sclerosis (SSc) is an autoimmune disorder that affects multiple organs. It is characterised by a thickening of the dermis and connective tissue caused by collagen accumulation, and vascular injuries that induce hypoxia. The present study investigated the therapeutic potential of bone marrow-derived mesenchymal stem cells (BMSCs) expressing thioredoxin 1 (Trx-1) in treating SSc-mediated skin disease following transplantation into a bleomycin-induced murine model. Mice with bleomycin-induced SSc were subcutaneously injected with BMSCs or Trx-1-overexpressing BMSCs and exposed to hypoxic conditions for 48 h...
January 26, 2017: Journal of Investigative Dermatology
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