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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/30452903/the-collagen-prolyl-hydroxylases-are-bifunctional-growth-regulators-in-melanoma
#1
Aithne Atkinson, Alexander Renziehausen, Hexiao Wang, Cristiana Lo Nigro, Laura Lattanzio, Marco Merlano, Bhavya Rao, Lynda Weir, Alan Evans, Rubeta Matin, Catherine Harwood, Peter Szlosarek, J Geoffrey Pickering, Colin Fleming, Van Ren Sim, Su Li, James T Vasta, Ronald T Raines, Mathieu Boniol, Alastair Thompson, Charlotte Proby, Tim Crook, Nelofer Syed
Appropriate post-translational processing of collagen requires prolyl hydroxylation, catalyzed by the prolyl 3- (C-P3H) and prolyl 4- (C-P4H) hydroxylases is essential for normal cell function. Here we have investigated the expression, transcriptional regulation and function of the C-P3H and C-P4H families in melanoma. We show that the CP3H family exemplified by Leprel1 and Leprel2 are subject to methylation-dependent transcriptional silencing in primary and metastatic melanoma consistent with a tumour suppressor function...
November 16, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30448384/epidermal-barrier-function-is-impaired-in-langerhans-cell-depleted-mice
#2
Hae-Jin Lee, Tae-Gyun Kim, Sung Hee Kim, Jae Yeon Park, Minseok Lee, Jae Won Lee, Seung Hun Lee, Min-Geol Lee
No abstract text is available yet for this article.
November 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30448383/transglutaminase-1-replacement-therapy-successfully-mitigates-the-arci-phenotype-in-full-thickness-skin-disease-equivalents
#3
Roswitha Plank, Guy Yealland, Enrico Miceli, Dulce Lima Cunha, Patrick Graff, Sari Thomforde, Robert Gruber, Verena Moosbrugger-Martinz, Katja Eckl, Marcelo Calderón, Hans Christian Hennies, Sarah Hedtrich
No abstract text is available yet for this article.
November 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30448211/realistic-exposure-study-assists-risk-assessments-of-zno-nanoparticle-sunscreens-and-allays-safety-concerns
#4
Paul F A Wright
The findings of a new study by Mohammed et al. show that after repeated hourly or daily topical applications typically used for sunscreens, zinc oxide nanoparticles do not penetrate into the viable epidermis or cause toxicity in human skin. This important study confirms that the known benefits of using zinc oxide nanoparticles in sunscreen clearly outweigh the perceived risks of using nanosunscreens.
November 14, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30447238/lpa-induces-keratinocyte-differentiation-and-promotes-skin-barrier-function-through-the-lpar1-lpar5-rho-rock-srf-axis
#5
Akiko Sumitomo, Ratklao Siriwach, Dean Thumkeo, Kentaro Ito, Ryota Nakagawa, Nobuo Tanaka, Kohei Tanabe, Akira Watanabe, Mari Kishibe, Akemi Ishida-Yamamoto, Tetsuya Honda, Kenji Kabashima, Junken Aoki, Shuh Narumiya
The skin barrier protects our body from water loss, allergens and pathogens. Profilaggrin (proFLG) is produced by differentiated keratinocytes and is processed into FLG monomers. These monomers crosslink keratin filaments and are also decomposed to natural moisturizing factors in the stratum corneum for skin hydration and barrier function. Deficits in FLG expression impair skin barrier function and underlie skin diseases such as dry skin and atopic dermatitis (AD). However, intrinsic factors that regulate FLG expression and their mechanism of action remain unknown...
November 14, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30447237/the-molecular-basis-of-chemical-chaperone-therapy-for-oculocutaneous-albinism-type-1a
#6
Ayako Teramae, Yui Kobayashi, Hiroyuki Kunimoto, Koichi Nakajima, Tamio Suzuki, Daisuke Tsuruta, Kazuyoshi Fukai
Oculocutaneous albinism (OCA) is an autosomal recessive disease characterized by the reduction or complete lack of melanin pigment in the skin, hair and eyes. No effective treatment for OCA is available at present. OCA type 1 (OCA1) is caused by mutations that disrupt the function of tyrosinase (TYR), the rate-limiting enzyme of melanin synthesis. Recently, it was shown that tyrosinase in some OCA1 mutants is retained within the endoplasmic reticulum (ER) and its catalytic activity is lost, a phenomenon known as ER-retention...
November 14, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30448212/support-for-the-safe-use-of-zinc-oxide-nanoparticle-sunscreens-lack-of-skin-penetration-or-cellular-toxicity-after-repeated-application-in-volunteers
#7
Yousuf H Mohammed, Amy Holmes, Isha N Haridass, Washington Y Sanchez, Hauke Studier, Jeffrey E Grice, Heather A E Benson, Michael S Roberts
Zinc oxide is a widely used broad-spectrum sunscreen, but concerns have been raised about the safety of its nanoparticle (NP) form. We studied the safety of repeated application of agglomerated zinc oxide (ZnO) NPs applied to human volunteers over 5 days by assessing the skin penetration of intact ZnO-NPs and zinc ions and measuring local skin toxicity. Multiphoton tomography with fluorescence lifetime imaging microscopy was used to directly visualize ZnO-NP skin penetration and viable epidermal metabolic changes in human volunteers...
November 13, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30423330/risk-of-second-primary-cancer-in-survivors-of-in-situ-melanoma
#8
M G Kimlin, D R Youlden, A M Brodie, T DiSipio, P Youl, V Nair-Shalliker, P D Baade
Invasive melanoma survivors have an increased risk of developing second primary cancers, however, similar risks associated with in situ melanoma haven't been established. We evaluated 43,829 first primary in situ melanoma survivors diagnosed from 1982-2012 in Queensland, Australia. Risk of second non-melanoma primary cancers was estimated from standardized incidence ratios with 95% confidence intervals. A total of 4,917 (11.3%) in situ melanoma survivors developed a second primary cancer. No net increased risk compared with the general population was found...
November 10, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30423329/resident-memory-and-recirculating-memory-t-cells-cooperate-to-maintain-disease-in-a-mouse-model-of-vitiligo
#9
Jillian M Richmond, James P Strassner, Mehdi Rashighi, Priti Agarwal, Madhuri Garg, Kingsley I Essien, Lila S Pell, John E Harris
Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model. We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IFNγ, CXCL9, and CXCL10...
November 10, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30423328/biological-effects-of-il-26-on-t-cell-mediated-skin-inflammation-including-psoriasis
#10
Takumi Itoh, Ryo Hatano, Eriko Komiya, Haruna Otsuka, Yuka Narita, Thomas M Aune, Nam H Dang, Shuji Matsuoka, Hisashi Naito, Mitsutoshi Tominaga, Kenji Takamori, Chikao Morimoto, Kei Ohnuma
Psoriasis is a chronic inflammatory skin disease mainly characterized by epidermal hyperplasia, scaling and erythema, with Th17 cells having a role in its pathogenesis. Although IL-26, known as a Th17 cytokine, is upregulated in psoriatic skin lesions, its precise role is unclear. We now investigate the role of IL-26 in the imiquimod (IMQ)-induced psoriasis-like murine model using human IL-26 transgenic (hIL-26Tg) mice. Erythema symptoms induced by daily applications of IMQ dramatically increased in hIL-26Tg mice as compared with controls...
November 10, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30423327/smad7-ameliorates-tgf%C3%AE-mediated-skin-inflammation-and-associated-wound-healing-defects-but-not-the-susceptibility-to-experimental-skin-carcinogenesis
#11
Fulun Li, Li Bian, Shunsuke Iriyama, Zhe Jian, Bin Fan, Jing Jing Luo, Dongyan D Wang, Christian D Young, Gangwen Han, Xiao-Jing Wang
We assessed roles of Smad7 in skin inflammation and wound healing using genetic and pharmacological approaches. In K5.TGFβ1/K5.Smad7 bigenic (double transgenic) mice, Smad7 transgene expression reversed TGFβ1 transgene-induced inflammation, fibrosis and subsequent epidermal hyperplasia, and molecularly abolished TGFβ and NF-κB activation. Next, we produced recombinant human Smad7 protein with a Tat-tag (Tat-Smad7) that rapidly enters cells. Subcutaneous injection of Tat-Smad7 attenuated infiltration of F4/80+ and CD11b+ leukocytes and αSMA+ fibroblasts prior to attenuating epidermal hyperplasia in K5...
November 10, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30414911/racial-ethnic-differences-in-incidence-and-persistence-of-childhood-atopic-dermatitis
#12
Yuhree Kim, Maria Blomberg, Sheryl L Rifas-Shiman, Carlos A Camargo, Diane R Gold, Jacob P Thyssen, Augusto A Litonjua, Emily Oken, Maryam M Asgari
Although previous studies have explored racial/ethnic differences in incident atopic dermatitis (AD) in childhood, few studies have examined risk factors associated with AD persistence. As such, we sought to examine differences in incidence and persistence of childhood AD by race/ethnicity accounting for socio-demographic characteristics and perinatal vitamin D levels. Using data from Project Viva, a prospective pre-birth cohort in eastern Massachusetts, we studied 1,437 mother-child pairs with known AD status to examine the associations of race/ethnicity with maternally-reported child AD...
November 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30414910/altered-notch-signaling-in-dowling-degos-disease-additional-mutations-in-poglut1-and-further-insights-into-disease-pathogenesis
#13
Damian J Ralser, Hideyuki Takeuchi, Günter Fritz, F Buket Basmanav, Maike Effern, Sugirthan Sivalingam, Laila El-Shabrawi-Caelen, Ece N Degirmentepe, Emek Kocatürk, Manuraj Singh, Nina Booken, Natalia M K Spierings, Viktor Schnabel, Andre Heineke, Jana Knuever, Sabrina Wolf, Maria Wehner, Michael Tronnier, Martin Leverkus, Iliana Tantcheva-Poór, Jörg Wenzel, Vinzenz Oji, Cristina Has, Michael Hölzel, Jorge Frank, Robert S Haltiwanger, Regina C Betz
No abstract text is available yet for this article.
November 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30414909/are-bacteria-infectious-pathogens-in-hidradenitis-suppurativa-hs-debate-at-the-symposium-for-hidradenitis-suppurativa-advances-meeting-november-2017
#14
Haley B Naik, Aude Nassif, Mayur S Ramesh, Gregory Schultz, Vincent Piguet, Afsaneh Alavi, Michelle A Lowes
In November 2017, a formal debate on the role of bacteria in the pathogenesis of hidradenitis suppurativa (HS) was held at the 2nd Symposium on Hidradenitis Suppurativa Advances (SHSA) in Detroit, MI. In this report, we present both sides of the argument as debated at the SHSA meeting, and then discuss the potential role of bacteria as classic infectious pathogens versus an alternative pathogenic role as activators of dysregulated commensal bacterial-host interactions. While there was consensus that bacteria play a role in pathogenesis, and thus are pathogenic, there was a compelling discussion about whether bacteria in HS incite an infectious disease as we classically understand it, or whether bacteria might play a different role in HS pathogenesis...
November 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30414908/a-preclinical-model-for-studying-herpes-simplex-virus-infection
#15
Pooja Tajpara, Michael Mildner, Ralf Schmidt, Martin Vierhapper, Johannes Matiasek, Theresia Popow-Kraupp, Christopher Schuster, Adelheid Elbe-Bürger
Herpes simplex virus (HSV) infections can cause considerable morbidity. Currently, nucleoside analogues such as acyclovir are widely used for treatment. However, HSV infections resistant to these drugs are a clinical problem among immunocompromised patients. To provide more efficient therapy and to counteract resistance, a different class of antiviral compounds has been developed. Pritelivir, a helicase primase inhibitor, represents a promising candidate for improved therapy. Here, we established a HSV-1 infection model on microneedle-pretreated human skin ex vivo...
November 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30414907/tweak-fn14-interaction-confers-aggressive-properties-to-cutaneous-squamous-cell-carcinoma
#16
Guanglei Hu, Lili Liang, Yale Liu, Jing Liu, Xuanfeng Tan, Meifeng Xu, Lingling Peng, Siyue Zhai, Qingyan Li, Zhaowei Chu, Weihui Zeng, Yumin Xia
Recent studies showed that tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) signaling participates in the progression of internal malignancies. However, its role in the biological properties of cutaneous squamous cell carcinoma (SCC) remains unclear. This study was designed to explore the effect of TWEAK/Fn14 activation on cutaneous SCC as well as the relevant mechanism. The expression of TWEAK and Fn14 was determined in tissue samples of patients with cutaneous SCC...
November 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30404022/lentigines-formation-in-caucasian-women-interaction-between-particulate-matter-and-solar-ultraviolet-radiation
#17
Anke Hüls, Dorothee Sugiri, Kateryna Fuks, Jean Krutmann, Tamara Schikowski
No abstract text is available yet for this article.
November 4, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30404021/aging-in-skin-of-color-disruption-to-elastic-fiber-organization-is-detrimental-to-skin-s-biomechanical-function
#18
A K Langton, S Alessi, M Hann, A L Chien, S Kang, C E M Griffiths, R E B Watson
Skin aging is a complex process involving the additive effects of time-dependent intrinsic aging and changes elicited via skin's interaction with the environment. Maintaining optimal skin function is essential for healthy aging across global populations; yet most research focuses on lightly-pigmented skin (Fitzpatrick phototypes I-III), with little emphasis on skin of color (Fitzpatrick phototypes V-VI). Here, we explore the biomechanical and histologic consequences of aging in black African-American volunteers...
November 4, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30404020/the-calcium-sensing-receptor-regulates-epidermal-intracellular-ca-2-signaling-and-re-epithelialization-after-wounding
#19
Chia-Ling Tu, Anna Celli, Theodora Mauro, Wenhan Chang
Extracellular Ca2+ (Ca2+ o ) is a crucial regulator of epidermal homeostasis and its receptor, the Ca2+ -sensing receptor (CaSR), conveys the Ca2+ o signals to promote keratinocyte adhesion, differentiation, and survival via activation of intracellular Ca2+ (Ca2+ i ) and E-cadherin-mediated signaling. Here, we took genetic loss-of-function approaches to delineate the functions of CaSR in wound re-epithelialization. Cutaneous injury triggered a robust CaSR expression and a surge of Ca2+ i in epidermis. CaSR and E-cadherin were co-expressed at the cell-cell membrane between migratory keratinocytes in the nascent epithelial tongues...
November 4, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/30404019/the-regulation-of-skin-fibrosis-in-systemic-sclerosis-by-extracellular-atp-via-p2y-2-purinergic-receptor
#20
Liyanage Manosika Buddhini Perera, Akiko Sekiguchi, Akihiko Uchiyama, Akihito Uehara, Chisako Fujiwara, Sahori Yamazaki, Yoko Yokoyama, Sachiko Ogino, Ryoko Torii, Mari Hosoi, Osamu Ishikawa, Sei-Ichiro Motegi
Tissue injury/hypoxia and oxidative stress induced-extracellular ATP can act as a damage-associated molecular pattern molecules (DAMPs), which initiates inflammatory response. Objective was to elucidate the role of extracellular ATP in skin fibrosis in systemic sclerosis (SSc). We identified that hypoxia enhanced ATP release, and extracellular ATP enhanced IL-6 production more significantly in SSc fibroblasts than in normal fibroblasts. There were no significant differences of P2X and P2Y receptors expressions between normal and SSc fibroblasts...
November 4, 2018: Journal of Investigative Dermatology
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