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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/28344062/il-21-may-promote-granzyme-b-dependent-nk-plasmacytoid-dendritic-cell-functional-interaction-in-cutaneous-lupus-erythematosus
#1
Valentina Salvi, William Vermi, Andrea Cavani, Silvia Lonardi, Teresa Carbone, Fabio Facchetti, Daniela Bosisio, Silvano Sozzani
Autoimmune skin lesions are characterized by a complex cytokine milieu and by the accumulation of plasmacytoid dendritic cells (pDCs). Granzyme B (GrB) transcript is abundant in activated pDCs, though its mechanisms of regulation and biological role are largely unknown. Here we report that IL-21 was the only Th1/Th17 cytokine able to induce the expression and secretion of GrB by pDCs and that this action was counteracted by the autocrine production of type I interferons (IFNs). In lupus erythematosus (LE) skin lesions, the percentage of GrB(+) pDCs directly correlated with the IL-21/MxA ratio, indicating that the interplay between these two cytokines finely tune the levels of pDC-dependent GrB also in vivo...
March 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28344061/compartmentation-of-mitochondrial-and-oxidative-metabolism-in-growing-hair-follicles-a-ring-of-fire
#2
John J Lemasters, Venkat K Ramshesh, Gregory L Lovelace, John Lim, Graham D Wright, Duane Harland, Thomas L Dawson
Little is known about the energetics of growing hair follicles, particularly in the mitochondrially abundant bulb. Here, mitochondrial and oxidative metabolism was visualized by multiphoton and light sheet microscopy in cultured bovine hair follicles and plucked human hairs. Mitochondrial membrane potential (ΔΨ), cell viability, reactive oxygen species (ROS) and secretory granules were assessed with parameter-indicating fluorophores. In growing follicles, lower bulb epithelial cells had high viability, and mitochondria were polarized...
March 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28315658/transglutaminase-3-protects-against-photodamage
#3
Valentina Frezza, Alessandro Terrinoni, Consuelo Pitolli, Alessandro Mauriello, Gerry Melino, Eleonora Candi
No abstract text is available yet for this article.
March 15, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28300598/palladium-and-platinum-nanoparticles-activate-ahr-and-nrf2-in-human-keratinocytes-implications-in-vitiligo-therapy
#4
Gaku Tsuji, Akiko Hashimoto-Hachiya, Masaki Takemura, Takaaki Kanemaru, Masamitsu Ichihashi, Masutaka Furue
No abstract text is available yet for this article.
March 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28300597/gli2-is-a-regulator-of-%C3%AE-catenin-and-is-associated-with-loss-of-e-cadherin-cell-invasiveness-and-long-term-epidermal-regeneration
#5
Eleni Pantazi, Emilios Gemenetzidis, Muy-Teck Teh, Sreekanth Vootukuri Reddy, Gary Warnes, Chris Evagora, Giuseppe Trigiante, Michael P Philpott
Uncontrolled HH/GLI and WNT/β-catenin signaling are important events in the genesis of many cancers including skin cancer and are often implicated in tumour progression, invasion and metastasis. However, due to the complexity and context-dependency of both pathways, little is known about HH and WNT interactions in human carcinogenesis. In the current study we provide evidence of HH/GLI2-WNT/β-catenin signaling crosstalk in human keratinocytes. Over-expression of GLI2ΔN in human keratinocytes resulted in cytoplasmic accumulation and nuclear relocalization of β-catenin in vitro and in 3D-organotypic cultures, accompanied by upregulation of WNT genes...
March 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28288848/bcl11b-mediated-epigenetic-repression-is-a-crucial-target-for-histone-deacetylase-inhibitors-in-cutaneous-t-cell-lymphoma
#6
Wenjing Fu, Shengguo Yi, Lei Qiu, Jingru Sun, Ping Tu, Yang Wang
The treatment options for advanced cutaneous T-cell lymphoma (CTCL) are limited due to its unclear pathogenesis. HDAC inhibitors (HDACi) are recently developed therapeutics approved for refractory CTCL. However, the response rate is relatively low and unpredictable. Previously, we discovered that BCL11B, a key T-cell development regulator, was aberrantly overexpressed in mycosis fungoides (MF), the most common CTCL, as compared with benign inflammatory skin. In the current study, we identified positive correlation between BCL11B expression and the sensitivity to HDACi in CTCL lines...
March 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28288847/increased-frequency-and-vasculogenic-potential-of-endothelial-colony-forming-cells-in-patients-with-kaposi-s-sarcoma
#7
Francesca Calcaterra, Lucia Brambilla, Elena Colombo, Athanasia Tourlaki, Stefano Veraldi, Claudia Carenza, Domenico Mavilio, Silvia Della Bella
Kaposi's sarcoma (KS) is characterized by hyperproliferation of spindle cells that have an endothelial origin and assume their characteristic features upon infection with human herpesvirus-8 (HHV8), the causative agent for KS. The multifocal nature of KS suggests that spindle cells derive from circulating HHV8-infected precursors that yet lack identification. We investigated whether ECFCs obtained from KS patients may be putative precursors of spindle cells, by assessing whether their in vitro behavior may evoke the in vivo behavior of KS spindle cells...
March 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28288846/pleiotropic-fty720-is-a-specific-and-potent-therapy-for-hypertrophic-scars
#8
Fen Shi, Xiaoling Cao, Zhicheng Hu, Da Ma, Dong Guo, Jian Zhang, Changlin Zhang, Peng Liu, Shanqiang Qu, Jiayuan Zhu, Wuguo Deng, Bing Tang
Hypertrophic scars (HS) is a fibrotic skin condition characterized by aberrant fibroblast phenotypes and excessive deposition of extracellular matrix components. 2-Amino-2-[2-(4-octylphenyl)]-1, 3-propanediol hydrochloride (FTY720), an immunomodulator approved for treating multiple sclerosis, is reported to attenuate fibrosis in multiple disease models. Here we found that FTY720 could significantly attenuate the proliferation and fibrosis in HS fibroblasts (HSFs) as well as in animal HS model. Upon treating HSFs or normal dermal fibroblasts (NFs) with FTY720 at different concentrations for different time periods, we found that FTY720 presented a pleiotropic effect specifically on HSFs, but not NFs, including reducing cell viability, arresting cell cycle progression at G0/G1 phase, promoting apoptosis, inhibiting migration and contraction, and suppressing the expressions of α-smooth muscle actin (α-SMA), collagen I, and collagen III...
March 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28286062/mirnas-are-required-for-post-induction-stage-sweat-gland-development
#9
Chang-Yi Cui, Yulan Piao, Dean P Campbell, Ryuga Ishii, Marc Michel, Alexei Sharov, David Schlessinger
No abstract text is available yet for this article.
March 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28286061/tnf-alpha-antagonist-and-vascular-inflammation-in-patients-with-psoriasis-vulgaris-a-randomized-placebo-controlled-study
#10
Robert Bissonnette, François Harel, James G Krueger, Marie-Claude Guertin, Malorie Chabot-Blanchet, Juana Gonzalez, Catherine Maari, Isabelle Delorme, Charles W Lynde, Jean-Claude Tardif
BACKGROUND: Vascular inflammation is increased in patients with psoriasis. PURPOSE: This randomized, double-blind, multicenter study evaluated the effects of the tumor necrosis factor alpha (TNF-α) antagonist adalimumab on vascular inflammation in patients with psoriasis. METHOD: 107 patients were randomized (1:1) to receive adalimumab for 52 weeks OR placebo for 16 weeks followed by adalimumab for 52 weeks. Vascular inflammation was assessed with positron emission tomography-computed tomography...
March 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28274739/dual-role-of-act1-in-keratinocyte-differentiation-and-host-defense-traf3ip2-silencing-alters-keratinocyte-differentiation-while-inhibiting-il-17-responses
#11
Sylviane Lambert, William R Swindell, Lam C Tsoi, Stefan W Stoll, James T Elder
TRAF3IP2 is a candidate psoriasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 receptor to downstream signaling pathways. We investigated the role of Act1 in keratinocyte responses to IL-17 using a tetracycline inducible shRNA targeting TRAF3IP2. Tet exposure for seven days effectively silenced TRAF3IP2 mRNA and Act1 protein, resulting in 761 genes with significant changes in expression (495 down, 266 up, >1.5-fold, p<0.05). Gene Ontology analysis revealed that genes affected by TRAF3IP2 silencing are involved in epidermal differentiation, with early differentiation genes (KRT1, KRT10, DSC1, DSG1) being downregulated and late differentiation genes (SPRR2, SPRR3, LCE3) being upregulated...
March 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259688/hair-growth-cycle-is-arrested-in-scd1-deficiency-by-impaired-wnt3a-palmitoleoylation-and-retrieved-by-artificial-lipid-barrier
#12
Wilhelm Stoffel, Inga Schmidt-Soltau, Britta Jenke, Erika Binczek, Ina Hammels
Stearoyl-CoA desaturase 1 (SCD1) is the dominant member of the SCD-isozyme family, regarded as a major regulator of lipid and energy metabolism in liver and adipose tissue. SCD1-deficiency impairs the desaturation of de novo-synthesized palmitoyl- and stearoyl-CoA to palmitoleoyl- and oleoyl- CoA. Scd1-/- mice develop metabolic waste syndrome and skin lesions: epidermal barrier disruption, alopecia and degeneration of sebaceous glands. The unifying molecular link between the two divergent traits remains incompletely understood...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259687/inpatient-financial-burden-of-atopic-dermatitis-in-the-united-states
#13
Shanthi Narla, Derek Y Hsu, Jacob P Thyssen, Jonathan I Silverberg
Little is known about the inpatient burden of atopic dermatitis (AD). We sought to determine some risk factors and financial-burden of hospitalizations for AD in the US. Data were analyzed from the 2002-2012 National Inpatient Sample, including of a 20% representative sample of all hospitalizations in the US. Hospitalization rates for AD or eczema (AD-E) were highest in the northeast during the winter and south during the summer. Geometric mean cost of care [95% CI] was lower for a primary diagnosis of AD-E vs...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259686/skin-treatment-with-detergent-promotes-protease-allergen-dependent-epicutaneous-sensitization-in-a-manner-different-from-tape-stripping-in-mice
#14
Hirono Ochi, Toshiro Takai, Sakiko Shimura, Natsuko Maruyama, Izumi Nishioka, Seiji Kamijo, Hideo Iida, Susumu Nakae, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda
No abstract text is available yet for this article.
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259685/endogenous-glucocorticoid-deficiency-in-psoriasis-promotes-inflammation-and-abnormal-differentiation
#15
Mrinal K Sarkar, Nihal Kaplan, Lam C Tsoi, Xianying Xing, Yun Liang, William R Swindell, Paul Hoover, Maya Aravind, Gleb Baida, Matthew Clark, John J Voorhees, Rajan P Nair, James T Elder, Irina Budinova, Spiro Getsios, Johann E Gudjonsson
The factors involved in maintaining a localized inflammatory state in psoriatic skin remain poorly understood. Here, we demonstrate through metabolomic and transcriptomic profiling marked suppression of glucocorticoid biosynthesis in the epidermis of psoriatic skin leading to localized deficiency of cortisol. Utilizing a 3D human epidermis model, we demonstrate that glucocorticoid biosynthesis is suppressed by pro-inflammatory cytokines and that glucocorticoid deficiency promotes inflammatory responses in keratinocytes...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259684/ablation-of-ctip2-bcl11b-in-adult-epidermis-enhances-tpa-uv-induced-proliferation-and-increases-susceptibility-to-dmba-tpa-induced-epidermal-carcinogenesis
#16
Shreya Bhattacharya, Shan Li, Heather Wheeler, Rong Wang, Christiane V Lohr, Mark Leid, Gitali Ganguli-Indra, Arup K Indra
No abstract text is available yet for this article.
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259683/inhibition-of-sebum-production-with-the-acetyl-coenzyme-a-carboxylase-inhibitor-olumacostat-glasaretil
#17
David W Hunt, Geoffrey C Winters, Roger W Brownsey, Jerzy E Kulpa, Kathryn L Gilliland, Diane M Thiboutot, Hans E Hofland
Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC), the enzyme which controls the first, rate limiting step in fatty acid biosynthesis. Inhibition of ACC activity in the sebaceous glands is designed to substantially impact sebum production since over 80% of human sebum components contain fatty acids. OG inhibits de novo lipid synthesis in primary and transformed human sebocytes. TrueMass® Sebum Panel analyses revealed a reduction in saturated and monounsaturated fatty acyl chains across lipid species, including di- and triacylglycerols, phospholipids, cholesteryl esters, and wax esters in OG treated sebocytes...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259682/cross-cultural-validation-of-the-quality-of-life-in-hand-eczema-questionnaire-qolheq
#18
Robert F Ofenloch, Jart A F Oosterhaven, Päivikki Susitaival, Åke Svensson, Elke Weisshaar, Keiko Minamoto, Meltem Onder, Marie-Louise A Schuttelaar, Emel Bulbul Baskan, Thomas L Diepgen, Christian Apfelbacher
The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is the only instrument assessing disease-specific Health-Related Quality of Life (HRQOL) in hand eczema patients. It is available in eight language versions. In this study we assessed if the items of different language versions of the QOLHEQ yield comparable values across countries. An international multi-center study was conducted with participating centers in Finland, Germany, Japan, the Netherlands, Sweden and Turkey. Methods of item response theory (IRT) were applied to each subscale to assess differential item functioning (DIF) for items between countries...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259681/stem-cell-laden-hyaluronic-acid-based-spongy-like-hydrogels-for-an-integrated-healing-of-diabetic-wounds-pathophysiologies
#19
Lucília Pereira da Silva, Tírcia Carlos Santos, Daniel Barreira Rodrigues, Rogério Pedro Pirraco, Mariana Teixeira Cerqueira, Rui Luís Reis, Vitor Manuel Correlo, Alexandra Pinto Marques
The correlation between the pathophysiologies of diabetic foot ulcerations is yet to be established and improved treatments are still required. We propose a strategy that directs inflammation, neo-vascularization and neo-innervation of diabetic wounds. Aiming to potentiate a relevant secretome for nerve regeneration, stem cells were pre-cultured in hyaluronic acid-based spongy-like hydrogels under neurogenic/standard media prior transplantation into diabetic mice full-thickness wounds. Acellular spongy-like hydrogels and empty wounds were used as controls...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259680/slc1a3-creer-as-a-targeting-tool-for-the-k6-epithelial-stem-cell-niche-and-its-precursors-during-mouse-hair-follicle-cycle
#20
Aiko Sada, Prachi Jain, Sherry Wang, Eva Leung, Tudorita Tumbar
No abstract text is available yet for this article.
March 1, 2017: Journal of Investigative Dermatology
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