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Journal of Investigative Dermatology

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https://www.readbyqxmd.com/read/28736236/patients-with-hidradenitis-suppurativa-have-a-high-psychiatric-disease-burden-a-finnish-nationwide-registry-study
#1
Laura Huilaja, Hannu Tiri, Jari Jokelainen, Markku Timonen, Kaisa Tasanen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles which is associated with various comorbidities. In order further to clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4381 patients with HS and 39554 psoriasis and 43248 melanocytic nevi patients as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. The incidence of HS was 2.7/100,000 persons/year. At least one psychiatric diagnosis was found in 24...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736235/hla-a-26-is-correlated-with-response-to-nivolumab-in-japanese-melanoma-patients
#2
Yoshihiro Ishida, Atsushi Otsuka, Hidenori Tanaka, Mitchell P Levesque, Reinhard Dummer, Kenji Kabashima
No abstract text is available yet for this article.
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736234/the-potential-of-muse-cells-for-regenerative-medicine-of-skin-procedures-to-reconstitute-skin-with-muse-cell-derived-keratinocytes-fibroblasts-and-melanocytes
#3
Takeshi Yamauchi, Kenshi Yamasaki, Kenichiro Tsuchiyama, Saaya Koike, Setsuya Aiba
No abstract text is available yet for this article.
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736233/continued-increase-in-melanoma-incidence-across-all-socioeconomic-status-groups-in-california-1998-2012
#4
Christina A Clarke, Meg McKinley, Susan Hurley, Robert W Haile, Sally L Glaser, Theresa H M Keegan, Susan M Swetter
Melanoma incidence has been increasing in light-skinned populations worldwide, but the reasons for the increase have been controversial. Our prior assessment in California non-Hispanic whites showed substantial increases in invasive melanoma incidence for tumors of all thicknesses in all neighborhoods categorized by socioeconomic status (SES) between 1988-1992 and 1998-2002. To understand whether these trends continued, we updated our assessment to include the diagnosis period 2008-2012 and more accurate pathologic stage at diagnosis...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736232/stage-specific-embryonic-antigen-4-ssea-4-as-a-distinguishing-marker-between-eccrine-and-apocrine-origin-of-ducts-of-sweat-glands
#5
Julia Borowczyk-Michalowska, Eliza Zimolag, Piotr Konieczny, Anna Chrapusta, Zbigniew Madeja, Justyna Drukala
No abstract text is available yet for this article.
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736231/serial-or-parallel-metastasis-of-cutaneous-melanoma-a-study-of-the-german-central-malignant-melanoma-registry
#6
Maximilian Gassenmaier, Thomas Kurt Eigentler, Ulrike Keim, Matthias Goebeler, Eckhard Fiedler, Gerold Schuler, Ulrike Leiter, Benjamin Weide, Eva-Maria Grischke, Peter Martus, Claus Garbe
For more than a century the Halstedian hypothesis of contiguous metastasis from the primary tumor through the lymphatics to distant sites shaped the lymph node surgery for melanoma. We challenge this dogma of serial metastatic dissemination. A single-center series of 2299 patients with cutaneous metastatic melanoma was investigated to analyze overall survival (OS) and distant metastasis-free survival (DMFS) of stage IV patients with or without primary lymphatic metastasis. Results were then compared with those of 2134 patients from three independent centers of the German Central Malignant Melanoma Registry...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736230/pro-inflammatory-chemokines-and-cytokines-dominate-the-blister-fluid-molecular-signature-in-epidermolysis-bullosa-patients-and-affect-leukocyte-and-stem-cell-migration
#7
Vitali Alexeev, Julio Cesar Salas-Alanis, Francis Palisson, Lila Mukhtarzada, Giulio Fortuna, Jouni Uitto, Andy South, Olga Igoucheva
Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic non-healing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, recruitment of therapeutic cells to blistering skin and to more advanced skin lesions remains a challenge. Here, we analyzed cytokines and chemokines in blister fluids (BF) of patients affected by dystrophic, junctional and simplex EB. Our analysis revealed high levels of CXCR1, CXCR2, CCR2 and CCR4 ligands, particularly dominant in dystrophic and junctional EB...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736229/survival-of-patients-with-cutaneous-squamous-cell-carcinoma-results-of-a-prospective-cohort-study
#8
Thomas K Eigentler, Ulrike Leiter, Hans-Martin Häfner, Claus Garbe, Martin Röcken, Helmut Breuninger
Cutaneous squamous cell carcinoma (cSCC) is an increasing health burden in Caucasian populations. We prospectively assessed risk factors for tumour-specific and overall survival in 1434 patients who underwent surgery for cSCC between Jan 24, 2005, and May 29, 2015. A total of 2149 invasive cSCCs were analysed. Univariate and multivariate survival analyses included tumour thickness, horizontal size, body site, histological differentiation, desmoplastic growth, history of multiple cSCC, and immunosuppression...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28733202/v%C3%AE-4-%C3%AE-%C3%AE-t-cells-provide-an-early-source-of-il-17a-and-accelerate-skin-graft-rejection
#9
Yashu Li, Zhenggen Huang, Rongshuai Yan, Meixi Liu, Yang Bai, Guangping Liang, Xiaorong Zhang, Xiaohong Hu, Jian Chen, Chibing Huang, Baoyi Liu, Gaoxing Luo, Jun Wu, Weifeng He
Activated γδ T cells have been shown to accelerate allograft rejection. However, the precise role of skin-resident γδT cells and their subsets - Vγ5 (epidermis), Vγ1 and Vγ4 (dermis) - in skin graft rejection have not been identified. Here, using a male to female skin transplantation model, we demonstrated that Vγ4 T cells, rather than Vγ1 or Vγ5 T cells, accelerated skin graft rejection and that IL-17A was essential for Vγ4 T cell-mediated skin graft rejection. Moreover, we found that Vγ4 T cells were required for early IL-17A production in the transplanted area, both in skin grafts and in the host epidermis around grafts...
July 18, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28711386/lipofuscin-generated-by-uva-turns-keratinocytes-photosensitive-to-visible-light
#10
Paulo Newton Tonolli, Orlando Chiarelli-Neto, Carolina Santacruz-Perez, Helena Couto Junqueira, Ii-Sei Watanabe, Felipe Gustavo Ravagnani, Waleska Kerllen Martins, Maurício S Baptista
No abstract text is available yet for this article.
July 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28684330/spindle-cell-variant-of-primary-cutaneous-follicle-center-b-cell-lymphomas-are-germinal-center-b-cell-lymphomas-by-gene-expression-profiling-using-formalin-fixed-paraffin-embedded-specimen
#11
Ilske Oschlies, Christian W Kohler, Monika Szczepanowski, Karoline Koch, Artur Gontarewicz, Dieter Metze, Uwe Hillen, Julia Richter, Rainer Spang, Wolfram Klapper
No abstract text is available yet for this article.
July 3, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28684329/house-dust-mite-increases-pro-th2-cytokines-il-25-and-il-33-via-the-activation-of-tlr1-6-signaling
#12
Yong Hyun Jang, Jin Kyeong Choi, Meiling Jin, Young-Ae Choi, Zae Young Ryoo, Hyun-Shik Lee, Pil-Hoon Park, Sun-Uk Kim, Taeg Kyu Kwon, Myoung Ho Jang, Sin-Hyeog Im, Sun Young Moon, Weon Ju Lee, Seok-Jong Lee, Do Won Kim, Sang-Hyun Kim
House dust mite (HDM) has been implicated in the etiology and exacerbation of atopic dermatitis (AD). Diverse factors contribute to HDM allergenicity through the activation of innate immunity. We investigated whether Dermatophagoides farinae extract (DFE) allergens mediate innate immune activation through specific Toll-like receptors (TLRs) in epidermal keratinocytes, DFE-induced murine AD model and human AD lesions. DFE activated the expression of TLR1, TLR6, interleukin (IL)-25, and IL-33 in human primary keratinocytes and HaCaT cells...
July 3, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28668474/dermal-blimp1-acts-downstream-of-epidermal-tgf%C3%AE-and-wnt-%C3%AE-catenin-to-regulate-hair-follicle-formation-and-growth
#13
Stephanie B Telerman, Emanuel Rognoni, Inês Sequeira, Angela Oliveira Pisco, Beate M Lichtenberger, Oliver Culley, Priyalakshmi Viswanathan, Ryan R Driskell, Fiona M Watt
Blimp1 is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. While in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblast is unclear. Here we show that Blimp1 is dynamically regulated in dermal papilla (DP) cells during hair follicle (HF) morphogenesis and the postnatal hair cycle, preceding dermal Wnt/β-catenin activation. Blimp1 ablation in E12.5 mouse dermal fibroblasts delayed HF morphogenesis and growth and prevented new HF formation following wounding...
June 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28655516/characterization-of-autoantigen-presentation-by-hla-c-06-02-in-psoriasis
#14
Pengcheng Wei, Yi Yang, Zhaoxin Liu, Zuoqin Luo, Wenya Tu, Junyan Han, Yunhua Deng, Lei Yin
No abstract text is available yet for this article.
June 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652111/cannabinoid-reduces-inflammatory-cytokines-tumor-necrosis-factor-alpha-and-type-i-interferons-in-dermatomyositis-in-vitro
#15
Elizabeth S Robinson, Paul Alves, Muhammad M Bashir, Majid Zeidi, Rui Feng, Victoria P Werth
No abstract text is available yet for this article.
June 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652110/authors-response-to-using-fdg-pet-ct-to-detect-vascular-inflammation-in-patients-with-psoriasis-where-to-look-and-for-what
#16
Robert Bissonnette
No abstract text is available yet for this article.
June 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652109/using-fdg-pet-ct-to-detect-vascular-inflammation-in-patients-with-psoriasis-where-to-look-and-for-what
#17
Kasper Fjellhaugen Hjuler, Lars Christian Gormsen, Lars Iversen
No abstract text is available yet for this article.
June 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652108/hidradenitis-suppurativa-is-characterised-by-dysregulation-of-the-th17-treg-cell-axis-which-is-corrected-by-anti-tnf-therapy
#18
Barry Moran, Cheryl M Sweeney, Rosalind Hughes, Anna Malara, Shivashini Kirthi, Anne-Marie Tobin, Brian Kirby, Jean M Fletcher
Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating disease of hair follicles with 1-4% prevalence and high morbidity. There is a dearth of information on the pathogenesis and immune dysregulation underlying HS therefore we carried out a detailed analysis of skin infiltrating T cells. Cells isolated from skin biopsies and blood from HS patients and healthy controls were analysed by 16-parameter flow cytometry to provide detailed profiles of CD4 T cell subsets. We observed substantial infiltration of inflammatory T cells with a striking Th17-skewed cytokine profile in HS skin, these cells expressed the Th17 lineage marker CD161 and IL-17, as well as other pro-inflammatory cytokines GM-CSF, IL-22, IFN-γ, and TNF...
June 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652107/plasma-ppi-deficiency-is-the-major-but-not-the-exclusive-cause-of-ectopic-mineralization-in-an-abcc6-mouse-model-of-pxe
#19
Jingyi Zhao, Joshua Kingman, John P Sundberg, Jouni Uitto, Qiaoli Li
Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused in most cases by inactivating mutations in the ABCC6 gene. It was recently discovered that absence of ABCC6-mediated ATP release from the liver and consequently reduced plasma PPi levels underlie PXE. This study examined whether reduced levels of circulating PPi, an anti-mineralization factor, is the sole mechanism of PXE. The Abcc6(-/-) and Enpp1(asj) mice were crossed with transgenic mice expressing human ENPP1, an ectonucleotidase which generates PPi from ATP...
June 23, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28648952/extracellular-vesicles-as-biomarkers-and%C3%A2-therapeutics-in-dermatology-a%C3%A2-focus%C3%A2-on-exosomes
#20
REVIEW
Jeffrey D McBride, Luis Rodriguez-Menocal, Evangelos V Badiavas
Extracellular vesicles (exosomes, microvesicles, and apoptotic bodies) are ubiquitous in human tissues, circulation, and body fluids. Of these vesicles, exosomes are of growing interest among investigators across multiple fields, including dermatology. The characteristics of exosomes, their associated cargo (nucleic acids, proteins, and lipids), and downstream functions are vastly different, depending on the cell origin. Here, we review concepts in extracellular vesicle biology, with a focus on exosomes, highlighting recent studies in the field of dermatology...
June 22, 2017: Journal of Investigative Dermatology
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