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Journal of Investigative Dermatology

Majid Zeidi, Hee Joo Kim, Victoria P Werth
Although antimalarials are the primary treatment for cutaneous lupus erythematosus (CLE), not all patients are equally responsive. We investigated whether different inflammatory cell population and cytokine profiles in lesional CLE skin could affect the antimalarial responsiveness, and if hydroxychloroquine (HCQ) and quinacrine (QC) differentially suppress inflammatory cytokines. CLE patients were grouped according to their response to antimalarials (HCQ vs HCQ+QC). On immunohistochemistry, only the myeloid dendritic cell population was significantly increased in the HCQ+QC group compared to HCQ group...
September 15, 2018: Journal of Investigative Dermatology
Michael G Kemp, Smita Krishnamurthy, Michael N Kent, David L Schumacher, Priyanka Sharma, Katherine J D A Excoffon, Jeffrey B Travers
UVB wavelengths of light induce the formation of photoproducts in genomic DNA that are potentially mutagenic and detrimental to epidermal cell function. Interestingly, the mineralocorticoid and androgen receptor antagonist spironolactone (SP) was recently identified as an inhibitor of UV photoproduct removal in human cancer cells in vitro via its ability to promote the rapid proteolytic degradation of the DNA repair protein XPB (xeroderma pigmentosum group B). Using normal human keratinocytes in vitro and skin explants ex vivo, we find that SP rapidly depleted XPB protein in both systems and abrogated two major responses to UVB-induced DNA damage, including the removal of UV photoproducts from genomic DNA and the activation of the ATR/ATM DNA damage kinase signaling...
September 15, 2018: Journal of Investigative Dermatology
Kyong-Oh Shin, Kun Pyo Kim, Yunhi Cho, Min-Kyung Kang, Young-Hee Kang, Yong-Moon Lee, Hiroko Ikushiro, Mami Yokota, Takato Yano, Sung Jay Choe, Eung Ho Choi, Chae Jin Lim, Keedon Park, Walter M Holleran, Kyungho Park, Yoshikazu Uchida
The innate immune element, cathelicidin antimicrobial peptide (CAMP), is vital in the formation of the antimicrobial barrier in skin. CAMP production is increased during epidermal differentiation and enriched in the stratum corneum. We recently identified an endoplasmic reticulum (ER) stress-mediated sphingosine-1-phosphate (S1P)- dependent mechanism of CAMP synthesis. Interestingly, in this study, we found that S1P synthesized by an isoform of sphingosine kinase (SPHK), SPHK1, serves as a signal for CAMP synthesis; and conversely, another isoform SPHK2 likely has a suppressor role or no role in CAMP production...
September 15, 2018: Journal of Investigative Dermatology
Heinen Marie-Pierre, Cambier Ludivine, Antoine Nadine, Gabriel Annick, Gillet Laurent, Bureau Fabrice, Mignon Bernard
Dermatophytoses are among the most common fungal infections worldwide but little is known about the immune response in them. By comparing Trichophyton benhamiae acute superficial dermatophytosis in WT and Rag2-/- mice, we showed that TCR-mediated immunity is critical for fungal clearance and clinical recovery. In WT mice, CD4+ T-cells isolated from the skin-draining lymph nodes exhibit both Th1 and Th17 differentiation during infection, with regard to produced cytokines or mRNA levels of transcription factors...
September 15, 2018: Journal of Investigative Dermatology
Sai Yee Chuah, Amalina Binte Ebrahim Attia, Chris Jun Hui Ho, Xiuting Li, Joyce Siong-See Lee, Melissa Wee Ping Tan, Angeline Anning Yong, Aaron Wei Min Tan, Daniel Razansky, Malini Olivo, Steven Tien Guan Thng
No abstract text is available yet for this article.
September 15, 2018: Journal of Investigative Dermatology
Ji-Ae Kim, Rak-Kyun Seong, Sang Wook Son, Ok Sarah Shin
Zika virus (ZIKV) has emerged as a global pathogen causing significant public health concern. ZIKV infections in humans principally occur via mosquito bites. Thus, host skin cells are permissive to ZIKV infection and are the first line of defense against the virus. Here, we examined the role and mechanisms of antiviral skin immunity against ZIKV infection. ZIKV infection (African lineage MR766) in human dermal fibroblasts (HDFs), human epidermal keratinocytes (HEKn), and HaCaT keratinocytes resulted in distinct expression changes in retinoic acid-inducible gene (RIG-I)-like receptors (RLR), such as RIG-I and melanoma differentiation-associated gene 5 (MDA5)...
September 12, 2018: Journal of Investigative Dermatology
Qiu-Wen Tan, Shen-Li Tang, Yi Zhang, Ji-Qiao Yang, Zhu-Le Wang, Hui-Qi Xie, Qing Lv
As an important component of the skin, intradermal adipocytes are closely associated with skin homeostasis and wound healing. Although studies have focused on the role of fibroblasts, keratinocytes, and inflammatory cells in wound healing, the role of adipocytes has not been fully investigated. Here, we verified whether the induction of adipocyte regeneration in a wound bed can effectively promote wound healing, finding that the hydrogel from acellular porcine adipose tissue (HAPA) in combination with adipose-derived stem cells (ADSCs)can induce in situ adipogenesis in the wound microenvironment...
September 6, 2018: Journal of Investigative Dermatology
Philipp Kröll, Kristin Knoke, Julia Steiger, Mario Fabri
No abstract text is available yet for this article.
September 4, 2018: Journal of Investigative Dermatology
Sebastian Yu, Xuesong Wu, Yan Zhou, Dan Han, Leif S Anderson, Scott I Simon, Samuel T Hwang, Yasutomo Imai
No abstract text is available yet for this article.
September 4, 2018: Journal of Investigative Dermatology
Ana Korosec, Sophie Frech, Bernhard Gesslbauer, Martin Vierhapper, Christine Radtke, Peter Petzelbauer, Beate M Lichtenberger
Human skin dermis is comprised of the superficial papillary dermis and the reticular dermis in the lower layers, which can easily be distinguished histologically. In vitro analyses of fibroblasts from explant cultures from superficial and lower dermal layers suggest that human skin comprises at least two fibroblast lineages with distinct morphology, expression profiles and functions. However, while for mouse skin cell surface markers have been identified allowing the isolation of pure populations of one lineage or the other via fluorescence-activated cell sorting (FACS), this has not been achieved for human skin fibroblasts...
September 1, 2018: Journal of Investigative Dermatology
Joachim W Fluhr, Gaëlle Bellemère, Chiara Ferrari, Clarence De Belilovsky, Gaëtan Boyer, Nadège Lachmann, Colin P McGuckin, Nico Forraz, Razvigor Darlenski, Bernard Chadoutaud, Philippe Msika, Caroline Baudouin, Giovanni Pellacani
No abstract text is available yet for this article.
September 1, 2018: Journal of Investigative Dermatology
Jingyao Liang, Pingjiao Chen, Changxing Li, Dongmei Li, Jianqin Wang, Rujun Xue, Sanquan Zhang, Jianbo Ruan, Xibao Zhang
The roles of interleukin-22 (IL-22) in the pathomechanisms of psoriasis have been well demonstrated. Gap junctional intercellular communication (GJIC) is widely known for its involvement in multiple biological and pathological processes such as growth-related events, cell differentiation, and inflammation. Here, we show that IL-22 significantly decreased GJIC and downregulated Cx43 expression in HaCaT cells. Cx43 overexpression markedly inhibited the proliferation of and increased GJIC in HaCaT cells, while the silencing of Cx43 exerted the opposite effects...
August 29, 2018: Journal of Investigative Dermatology
Emmanuel Contassot
Acne vulgaris is treated with antibiotics and retinoids, but side effects are numerous. Novel safe and efficient therapies are still needed. Wang et al. demonstrate that the secreted virulence factor Christie-Atkins-Munch-Peterson factor 2 from Propionibacterium acnes, a bacterium involved in acne pathogenesis, promotes inflammatory responses. This proinflammatory property could be inhibited by antibodies to Christie-Atkins-Munch-Peterson factor 2, suggesting Christie-Atkins-Munch-Peterson factor 2 as a candidate target in acne vaccination...
August 26, 2018: Journal of Investigative Dermatology
Keith M Giles, Brooke E Rosenbaum, Marlies Berger, Allison Izsak, Yang Li, Irineu Illa Bochaca, Eleazar Vega-Saenz de Miera, Jinhua Wang, Farbod Darvishian, Hua Zhong, Iman Osman
The extent of PTEN loss that confers clinical and biological impact in melanoma is unclear. We evaluated the clinical and biologic relevance of PTEN dosage in melanoma, and tested the postulate that partial PTEN loss is due to epigenetic mechanisms. PTEN expression was assessed by immunohistochemistry in a stage III melanoma cohort (n=190) with prospective follow up. 21/190 (11%) of tumors had strong PTEN expression, 51/190 (27%) had intermediate PTEN, 44/190 (23%) had weak PTEN, and 74/190 (39%) had absent PTEN...
August 24, 2018: Journal of Investigative Dermatology
Cristina Solé, Sandra Domingo, Berta Ferrer, Teresa Moliné, Josep Ordi-Ros, Josefina Cortés-Hernández
Cutaneous lupus erythematosus (CLE) is a common and disfiguring manifestation in systemic lupus erythematosus (SLE). Subacute-cutaneous lupus erythematosus (SCLE) and discoid lupus erythematosus (DLE) are the most prevalent forms. Despite sharing histological similarities, clinically they differ in their course and prognosis, suggesting different pathogenesis. Here, we show that DLE-affected skin has a specific microRNA expression profile when compared with SCLE. Among the DLE-specific microRNAs, we identified one keratinocyte-derived microRNA, miR-31, and one leukocyte-derived microRNA, miR-485-3p...
August 18, 2018: Journal of Investigative Dermatology
Martijn G H Sanders, Luba M Pardo, Rebecca S Ginger, Jessica C Kiefte-de Jong, Tamar Nijsten
Current treatments for seborrheic dermatitis only provide a temporary relief. Therefore, identifying modifiable lifestyle factors may help to reduce disease burden. The objective of this study was to determine whether specific dietary patterns or total antioxidant capacity are associated with seborrheic dermatitis. Participants of the Rotterdam Study with a skin examination and a food-frequency questionnaire were included. Total antioxidant capacity was assessed on the basis of ferric reducing antioxidant potential of each food item...
August 18, 2018: Journal of Investigative Dermatology
Alexander Egeberg, Jacob P Thyssen, Johan Burisch, Jean-Frederic Colombel
In psoriasis patients, incidence rates (IRs) of Crohn's disease (CD) and ulcerative colitis (UC) have been increased in epidemiological studies and certain clinical trials, yet the association remains poorly understood. We studied a 20-year nationwide cohort of 235,038 Danish adults with psoriasis and a 1:1 matched reference group. Less than 1% of psoriasis patients developed CD or UC during follow-up. IRs of CD were highest for younger women with psoriasis and patients with concurrent psoriatic arthritis (PsA), whereas men with psoriasis had particularly high IRs of UC compared with their non-psoriasis peers...
August 18, 2018: Journal of Investigative Dermatology
Qiaoli Li, Jianhe Huang, Anthony B Pinkerton, Jose Luis Millan, B D van Zelst, Michael A Levine, John P Sundberg, Jouni Uitto
Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused by mutations in the ABCC6 gene encoding a putative efflux transporter ABCC6. It was recently demonstrated that the absence of ABCC6-mediated ATP release from the liver, and consequently reduced PPi levels, underlie the pathogenesis of PXE. Given that tissue-nonspecific alkaline phosphatase (TNAP), encoded by ALPL, is the enzyme responsible for degrading PPi, we hypothesized that reducing TNAP levels either by genetic or pharmacological means would lead to amelioration of the ectopic mineralization phenotype in the Abcc6-/- mouse model of PXE...
August 18, 2018: Journal of Investigative Dermatology
Nina Wilkinson, Teresa Tsakok, Nick Dand, Karien Bloem, Michael Duckworth, David Baudry, Angela Pushpa-Rajah, Christopher Em Griffiths, Nick Reynolds, Jonathan Barker, Richard B Warren, A David Burden, Theo Rispens, Deborah Stocken, Catherine Smith
Biologics have transformed management of inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by circulating drug levels has been proposed. We aimed to determine the real-world clinical utility of therapeutic drug monitoring in psoriasis. Within a multicenter (n=60) prospective observational cohort, 544 psoriasis patients were included who were on adalimumab monotherapy, with at least one serum sample and PASI (Psoriasis Area and Severity Index) score available within the first year...
August 18, 2018: Journal of Investigative Dermatology
Efrat Avigad Laron, Emil Aamar, David Enshell-Seijffers
No abstract text is available yet for this article.
August 15, 2018: Journal of Investigative Dermatology
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