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Journal of Infectious Diseases

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https://www.readbyqxmd.com/read/28645190/pcr-rflp-on-the-rdna-cannot-unequivocally-assign-ascaris-to-species-level-or-identify-hybrids
#1
Peter Nejsum, Martha Betson, Russell Stothard
No abstract text is available yet for this article.
June 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28645162/reply-to-nejsum-et-al
#2
Jeba R J Jesudoss Chelladurai, Matthew T Brewer
No abstract text is available yet for this article.
June 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633457/an-ha-stem-antibody-medi8852-prevents-and-controls-disease-and-limits-transmission-of-pandemic-influenza-viruses
#3
C I Paules, S Lakdawala, J M McAuliffe, M Paskel, L Vogel, N L Kallewaard, Q Zhu, K Subbarao
Background: MEDI8852 is a novel MAb which neutralizes both group I and group II influenza A viruses (IAV) in vitro. We evaluated whether MEDI8852 was effective for prophylaxis and therapy against representative group I (H5N1) and group II (H7N9) pandemic IAV in mice and ferrets and could be used to block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control MAb R347 and oseltamivir. Results: MEDI8852 was effective for prophylaxis and treatment of H7N9 and H5N1 infection in mice, with a clear dose-dependent response and treatment with MEDI8852 24, 48 or 72 h post-infection (hpi) was superior to oseltamivir for H5N1...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633455/fetal-metabolic-stress-disrupts-immune-homeostasis-and-induces-pro-inflammatory-responses-in-hiv-1-and-cart-exposed-infants
#4
Johannes C Schoeman, Gontse P Moutloatse, Amy C Harms, Rob J Vreeken, Henriette J Scherpbier, Liesbeth Van Leeuwen, Taco W Kuijpers, Carools J Reinecke, Ruud Berger, Thomas Hankemeier, Madeleine J Bunders
Increased morbidity and fetal growth restriction are reported in uninfected children born to HIV-1-infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress skewing the cell's immune response and restricting (cell) growth. Novel metabolomic techniques provided the opportunity to investigate the impact of fetal HIV-1 and combination ARV therapy (cART)-exposure on the infants' immune-metabolome. Peroxidized lipids, generated by reactive oxygen species, were increased in cART/HIV-1-exposed infants, indicating altered mitochondrial functioning...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633488/viral-diagnostics-only-half-the-battle
#5
Angela R Branche, Ann R Falsey
No abstract text is available yet for this article.
June 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633319/immunotherapy-targeting-adenosine-synthase-a-decreases-severity-of-staphylococcus-aureus-infection-in-mouse-model
#6
Bao-Zhong Zhang, JianPiao Cai, Bin Yu, Lifeng Xiong, Qiubin Lin, Xiao-Yan Yang, Chen Xu, SongYue Zheng, Richard Yi-Tsun Kao, Konghung Sze, Kwok-Yung Yuen, Jian-Dong Huang
Staphylococcus aureus (S. aureus) is a severe pathogen found in the community and in hospitals. Most notably, Methicillin-resistant S. aureus (MRSA) is resistant to almost all antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. Previous research showed that S. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. In this study, we investigated adenosine synthase A (AdsA), a S...
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633308/prior-season-vaccination-and-risk-of-influenza-during-the-2014-2015-season-in-the-u-s
#7
Jessie R Chung, Brendan Flannery, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson, Joshua G Petrie, Emily T Martin, Arnold S Monto, Huong Q McLean, Edward A Belongia, Manjusha Gaglani, Alicia M Fry
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633301/reply-to-chung-et-al
#8
Danuta M Skowronski, Catharine Chambers, Gaston De Serres
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633285/chronic-kidney-disease-in-the-aging-human-immunodeficiency-virus-infected-population
#9
Jeffrey B Kopp
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633282/editorial-host-attractiveness-and-malaria-transmission-to-mosquitoes
#10
Lauren Cator
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28605553/pyruvate-kinase-and-fc-gamma-receptor-gene-copy-numbers-associated-with-malaria-phenotypes
#11
Imad Faik, Hoang van Tong, Bertrand Lell, Christian G Meyer, Peter G Kremsner, Thirumalaisamy P Velavan
Genetic factors are associated with susceptibility to many infectious diseases and may be determinants of clinical progression. Gene copy number variation (CNV) has been shown to be associated with phenotypes of numerous diseases, including malaria. We quantified gene copy numbers of the pyruvate kinase, liver and red blood cells (PKLR) gene as well as of the Fcγ receptor 2A and Fcγ receptor 2C (FCGR2A, FCGR2C) and Fcγ receptor 3 (FCGR3) genes using real-time quantitative PCR (RT-qPCR) assays in Gabonese children with severe (n=184) or and mild (n=189) malaria and in healthy Gabonese and Caucasian individuals (n=76 each)...
June 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28605544/functional-analysis-reveals-geographical-variation-in-inhibitory-immune-responses-against-a-polymorphic-malaria-antigen
#12
Amy K Bei, Ambroise D Ahouidi, Jeffrey D Dvorin, Kazutoyo Miura, Ababacar Diouf, Daouda Ndiaye, Zul Premji, Mahamadou Diakite, Souleymane Mboup, Carole A Long, Manoj T Duraisingh
Background: PfRh2b is a P. falciparum invasion ligand that is a potential blood stage vaccine candidate antigen; however, a naturally occurring deletion within an immunogenic domain is present at high frequencies in Africa and has been associated with alternative invasion pathway usage. Standardized tools that provide antigenic specificity in in vitro assays are needed to functionally assess the neutralizing potential of humoral responses against malaria vaccine candidate antigens. Methods: Transgenic parasite lines were generated to express the PfRh2b deletion...
June 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28595330/contribution-of-progranulin-to-protective-lung-immunity-during-bacterial-pneumonia
#13
Shan Zou, Qin Luo, Zhixin Song, Liping Zhang, Yun Xia, Huajian Xu, Yu Xiang, Yibing Yin, Ju Cao
Background.: Progranulin (PGRN) is an important immunomodulatory factor in a variety of inflammatory diseases. However, its role in pulmonary immunity against bacterial infection remains unknown. Methods.: Pneumonia was induced in PGRN-deficient and normal wild-type mice using Pseudomonas aeruginosa or Staphylococcus aureus, and we assessed the effects of PGRN on survival, bacterial burden, cytokine and chemokine production, and pulmonary leukocyte recruitment after bacterial pneumonia...
June 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28591790/asian-g6pd-mahidol-reticulocytes-sustain-normal-plasmodium-vivax-development
#14
Germana Bancone, Benoit Malleret, Rossarin Suwanarusk, Nongnud Chowwiwat, Cindy S Chu, Rose McGready, Laurent Rénia, François Nosten, Bruce Russell
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approach to determine whether G6PD-MahidolG487A variant, a widespread cause of severe G6PD deficiency in Southeast Asia, provides a barrier against vivax malaria. Our results show that the immature reticulocytes (CD71+) targeted by P...
June 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28591778/sustained-immunogenicity-of-2-dose-human-papillomavirus-16-18-as04-adjuvanted-vaccine-schedules-in-girls-aged-9-14-years-a-randomized-trial
#15
Li-Min Huang, Thanyawee Puthanakit, Chiu Cheng-Hsun, Tang Ren-Bin, Tino Schwarz, Angelo Pellegrino, Susanna Esposito, Louise Frenette, Shelly McNeil, Paolo Durando, Paul Rheault, Carlo Giaquinto, Michael Horn, Karl Ulrich Petry, Klaus Peters, Toma Azhar, Peter Hillemanns, Stephanie De Simoni, Damien Friel, Suryakiran Pemmaraju, Marjan Hezareh, Florence Thomas, Dominique Descamps, Nicolas Folschweiller, Frank Struyf
Background.: We previously reported the noninferiority 1 month after the last dose of 2-dose human papillomavirus 16/18 AS04-adjuvanted (AS04-HPV-16/18) vaccine schedules at months 0 and 6 (2D_M0,6) and months 0 and 12 (2D_M0,12) in girls aged 9-14 years compared with a 3-dose schedule at months 0, 1, and 6 (3D_M0,1,6) in women aged 15-25 years. Here, we report the results at study end (month 36 [M36]). Methods.: Girls were randomized 1:1 and received 2 vaccine doses either 6 months (2D_M0,6) or 12 months apart (2D_M0,12); women received 3 doses at months 0, 1, and 6 (3D_M0,1,6)...
June 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28586473/exome-sequencing-identifies-two-variants-of-the-alkylglycerol-monooxygenase-gene-agmo-as-a-cause-of-relapses-in-visceral-leishmaniasis-in-children-in-sudan
#16
Sandrine Marquet, Bruno Bucheton, Camille Reymond, Laurent Argiro, Sayda Hassan El-Safi, Musa Mohamed Kheir, Jean-Pierre Desvignes, Christophe Béroud, Adil Mergani, Awad Hammad, Alain J Dessein
Background.: Visceral leishmaniasis (Kala-azar, KA) is the most severe form of leishmaniasis, characterized by fever, weight loss, hepatosplenomegaly and lymphadenopathy. During an outbreak of KA in Babar El Fugara (Sudan), 5.7% of cured patients displayed relapses, with familial clustering in half of the cases. Methods.: We performed whole-exome sequencing on 10 relapsing individuals and 11 controls from five nuclear families. Results.: Rare homozygous and compound-heterozygous nonsense (c...
June 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28586466/health-and-economic-impact-of-a-tender-based-gender-neutral-hpv16-18-vaccination-program-in-the-netherlands
#17
Venetia Qendri, Johannes A Bogaards, Johannes Berkhof
Background: Uptake among girls in the Dutch immunization program has plateaued around 60%. Vaccinating boys may be an appealing complementary strategy for the prevention of HPV-related diseases, especially since tender negotiations and reduced dosing schemes have driven down the cost of vaccination. Methods: We expanded a previously published Bayesian synthesis framework to account for all vaccine type-related cancers and herd immunity effects from vaccinating girls and boys...
June 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28586426/sensitive-detection-of-zika-virus-antigen-in-patients-whole-blood-as-an-alternative-diagnostic-approach
#18
Fok-Moon Lum, Cui Lin, Olga Y Susova, Teck-Hui Teo, Siew-Wai Fong, Tze-Minn Mak, Linda Kay Lee, Chia-Yin Chong, David C B Lye, Raymond T P Lin, Andres Merits, Yee-Sin Leo, Lisa F P Ng
Background.: Epidemics caused by the re-emergence of Zika virus (ZIKAV) warrant the need to develop new diagnostic measures to complement currently used detection methods. In this study, we explored the detection of ZIKAV antigen in a defined leucocyte subset from patient's whole blood. Methods.: Whole blood samples were obtained at the acute and early convalescent phase from ZIKAV-infected patients during the Singapore outbreak in Aug-Sep 2016. Presence of ZIKAV antigen was determined by flow cytometry staining for intracellular ZIKAV NS3 with a ZIKAV-specific polyclonal antibody...
June 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28549147/prevalence-and-concordance-of-cutaneous-beta-human-papillomavirus-infection-at-mucosal-and-cutaneous-sites
#19
Shalaka S Hampras, Dana E Rollison, Anna R Giuliano, Sandrine McKay-Chopin, Lucia Minoni, Karen Sereday, Tarik Gheit, Massimo Tommasino
Background: Cutaneous beta human papillomavirus (HPV) infection across cutaneous and mucosal tissues within individuals has not been examined. Methods: A sub-cohort of men (n=87) participating in the 'HPV infection in men' (HIM) study provided eyebrow hairs, forearm skin swabs, genital skin swabs, oral rinse samples and anal swabs. Beta HPV DNA in the five tissues was detected using a multiplex assay and site-specific beta HPV prevalence was examined. Results: Any beta HPV was most prevalent in genital skin (81...
May 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28549145/six-month-safety-data-of-recombinant-vesicular-stomatitis-virus-zaire-ebola-virus-envelope-glycoprotein-vaccine-in-a-phase-3-double-blind-placebo-controlled-randomized-study-in-healthy-adults
#20
Scott A Halperin, Jose R Arribas, Richard Rupp, Charles P Andrews, Laurence Chu, Rituparna Das, Jakub K Simon, Matthew T Onorato, Kenneth Liu, Jason Martin, Frans A Helmond
Background.: This study (NCT02503202) evaluated the safety of recombinant vesicular stomatitis virus-Zaire Ebola virus envelope glycoprotein vaccine (rVSVΔG-ZEBOV-GP). Methods.: Overall, 1197 subjects were randomized 2:2:2:2:1; 1194 were vaccinated with 1 dose of 1 of 3 lots of rVSVΔG- ZEBOV-GP (2 × 107 plaque-forming units [pfu], n = 797; combined-lots group), a single high-dose lot of rVSVΔG-ZEBOV-GP (1 × 108 pfu, n = 264; high-dose group), or placebo (n = 133)...
May 26, 2017: Journal of Infectious Diseases
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