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Journal of Infectious Diseases

Faiza A Siddiqui, Mynthia Cabrera, Meilian Wang, Awtum Brashear, Karen Kemirembe, Zenglei Wang, Jun Miao, Thanat Chookajorn, Zhaoqing Yang, Yaming Cao, Gang Dong, Philip J Rosenthal, Liwang Cui
Falcipain-2a (FP2a; PF3D7_1115700) is a Plasmodium falciparum cysteine protease and hemoglobinase. Functional FP2a is required for potent activity of artemisinin, and in vitro selection for artemisinin resistance selected for an FP2a nonsense mutation. To investigate associations between FP2a polymorphisms and artemisinin resistance and to characterize the diversity of the enzyme in parasites from the China-Myanmar border, we sequenced the full-length FP2a gene in 140 P. falciparum isolates collected during 2004-2011...
April 12, 2018: Journal of Infectious Diseases
Janet Mans
No abstract text is available yet for this article.
April 12, 2018: Journal of Infectious Diseases
Carolien E van de Sandt, Kyung A Sagong, Mark R Pronk, Theo M Bestebroer, Monique I Spronken, Marion P G Koopmans, Ron A M Fouchier, Guus F Rimmelzwaan
Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During more than six years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated four other amino acid substitutions...
April 12, 2018: Journal of Infectious Diseases
Fadima C Haidara, Milagritos D Tapia, Samba O Sow, Moussa Doumbia, Flanon Coulibaly, Fatoumata Diallo, Awa Traoré, Mamoudou Kodio, Corey L Kelly, Meagan Fitzpatrick, Karen Kotloff, John C Victor, Kathleen Neuzil
Background: Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year of life in low resource countries. Methods: We conducted an open-label, individual-randomized trial in Bamako, Mali. We assigned 600 9- to 11-month old infants to measles (MV), yellow fever (YFV), and meningococcal A conjugate vaccines with or without pentavalent rotavirus vaccine (PRV). We assessed non-inferiority of seroconversion and seroresponse rates (<10% difference) to MV, YFV and MenAV...
April 12, 2018: Journal of Infectious Diseases
Firas S Midani, Ana A Weil, Fahima Chowdhury, Yasmin A Begum, Ashraful I Khan, Meti D Debela, Heather K Durand, Aspen T Reese, Sai N Nimmagadda, Justin D Silverman, Crystal N Ellis, Edward T Ryan, Stephen B Calderwood, Jason B Harris, Firdausi Qadri, Lawrence A David, Regina C LaRocque
Background: Cholera is a public health problem worldwide and the risk factors for infection are only partially understood. Methods: We prospectively studied household contacts of cholera patients to compare those who were infected with those who were not. We constructed predictive machine learning models of susceptibility using baseline gut microbiota data. We identified bacterial taxa associated with susceptibility to Vibrio cholerae infection and tested these taxa for interactions with V...
April 12, 2018: Journal of Infectious Diseases
Kelsie Cassell, Paul Gacek, Joshua L Warren, Peter A Raymond, Matthew Cartter, Daniel M Weinberger
No abstract text is available yet for this article.
April 11, 2018: Journal of Infectious Diseases
Jerry F Brown, John M Dye, Sam Tozay, Gertrude Jeh-Mulbah, David A Wohl, William A Fischer, Coleen K Cunningham, Kathleen Rowe, Peter Zacharias, James van Hasselt, David A Norwood, Nathan M Thielman, Samantha E Zak, David L Hoover
Background: Ebola virus (EBOV) neutralizing antibody in plasma may reduce viral load following administration of plasma to patients with Ebola virus disease (EVD), but measurement of these antibodies is complex. Methods: Anti-EBOV antibody was measured by two neutralization and two enzyme linked immunosorbent assays (ELISAs) in convalescent plasma (ECP) from 100 EVD survivor donors in Liberia. Viral load was assessed repetitively in patients with EVD participating in a clinical trial of enhanced standard of care plus ECP...
April 11, 2018: Journal of Infectious Diseases
Stefanea L Rucinski, Matthew P Murphy, Kami D Kies, Scott A Cunningham, Audrey N Schuetz, Robin Patel
No abstract text is available yet for this article.
April 11, 2018: Journal of Infectious Diseases
Coraline Chéneau, Flora Coulon, Vanessa Porkolab, Franck Fieschi, Stéphanie Laurant, Diane Razanajaona-Doll, Jean-Jacques Pin, Eva Maria Borst, Martin Messerle, Céline Bressollette-Bodin, Franck Halary
Human cytomegalovirus (HCMV) is a leading cause of virally-induced congenital disorders and morbidities in immunocompromised individuals, i.e. transplant, cancer or AIDS patients. HCMV infects virtually all cell types through the envelope glycoprotein complex gH/gL/gO with our without a contribution of the pentameric gH/gL/pUL128L. Together with gH/gL, the HCMV envelope glycoprotein B (gB) contributes to the viral fusion machinery. We previously showed that gB is a ligand for the C-type lectin Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin (DC-SIGN) contributing to HCMV attachment to and infection of DC-SIGN expressing cells...
April 10, 2018: Journal of Infectious Diseases
Yeming Wang, Qiang Guo, Zheng Yan, Daming Zhou, Wei Zhang, Shujun Zhou, Yu-Ping Li, Jing Yuan, Timothy M Uyeki, Xinghua Shen, Wenjuan Wu, Hui Zhao, Yun-Fu Wu, Jia Shang, Zhengguang He, Yi Yang, Hongsheng Zhao, Yongqing Hong, Zehua Zhang, Min Wu, Tiemin Wei, Xilong Deng, Yijun Deng, Li-Hua Cai, Weihua Lu, Hongmei Shu, Lin Zhang, Hong Luo, Y Ing Zhou, Heng Weng, Keyi Song, Li Yao, Mingguang Jiang, Boliang Zhao, Ruibin Chi, Boqi Guo, Lin Fu, Long Yu, Haiyan Min, Pu Chen, Shuifang Chen, Liang Hong, Wei Mao, Xiaoping Huang, Lijun Gu, Hui Li, Chen Wang, Bin Cao
Background: Data are limited on the impact of neuraminidase inhibitor (NAI) treatment on avian influenza A(H7N9) virus RNA shedding. Methods: In this multicenter, retrospective study, data were collected from adults hospitalized with A(H7N9) infection during 2013-2017 in China. We compared clinical features and A(H7N9) shedding among patients with different NAI doses and combination therapies and evaluated factors associated with A(H7N9) shedding, using Cox proportional hazards regression...
April 10, 2018: Journal of Infectious Diseases
Petra Zimmermann, Adam Finn, Nigel Curtis
The incidence of non-tuberculous mycobacterial (NTM) infections is increasing worldwide, particularly NTM lymphadenitis and skin infections (Buruli ulcer). This review summarises the evidence for the protective effectiveness of Bacillus Calmette-Guérin (BCG) vaccination against NTM disease. A systematic search using PRISMA guidelines was done for controlled studies investigating the protective effectiveness of BCG vaccination against NTM disease in immunocompetent individuals. This revealed ten studies, including almost 12 million participants...
April 7, 2018: Journal of Infectious Diseases
(no author information available yet)
No abstract text is available yet for this article.
April 7, 2018: Journal of Infectious Diseases
Mary R Reichler, James Bangura, Dana Bruden, Charles Keimbe, Nadia Duffy, Harold Thomas, Barbara Knust, Ishmail Farmar, Erin Nichols, Amara Jambai, Oliver Morgan, Thomas Hennessy
BACKGROUND: Knowing risk factors for household transmission of Ebola virus is important to guide preventive measures during Ebola outbreaks. METHODS: We enrolled all confirmed persons with Ebola who were the first case in a household from December 2014-April 2015 in Freetown, Sierra Leone, and their household contacts. Cases and contacts were interviewed, contacts followed prospectively through the 21-day incubation period, and secondary cases confirmed by laboratory testing...
April 6, 2018: Journal of Infectious Diseases
J Bradley, S Floyd, E Piwowar-Manning, O Laeyendecker, A Young, N Bell-Mandla, J Bwalya, P Bock, S Fidler, H Ayles, R J Hayes
Background: HIV and Herpes simplex virus type-2 (HSV2) are strongly associated, although mechanisms are not fully understood. An HIV prevention trial allowed re-examination of this association at individual and community levels. Methods: HPTN 071 (PopART) evaluates a combination prevention intervention in 21 urban communities in Zambia and South Africa. To measure impact on HIV incidence, a cohort of ~2,000 adults (18-44y) was selected randomly from each community...
April 6, 2018: Journal of Infectious Diseases
Sinan Sari, Buket Dalgic, Atis Muehlenbachs, Marlene DeLeon-Carnes, Cynthia S Goldsmith, Ozgur Ekinci, Dhanpat Jain, M Kelly Keating, Silvia Vilarinho
Human protothecosis is a rare microalgae infection, and its dissemination typically occurs in immunocompromised individuals, but no specific immune defect has been reported. Here, we describe an 8-year-old daughter of a consanguineous union with abdominal pain and bloody diarrhea for 3 months who was found to have pancolitis with numerous microalgae identified as Prototheca zopfii. In the absence of a known immunodeficiency, exome sequencing was performed and uncovered a novel recessive frameshift mutation in CARD9 (p...
April 6, 2018: Journal of Infectious Diseases
Barbara Aparecida Chaves, Alessandra Silva Orfano, Paula Monalisa Nogueira, Nilton Barnabe Rodrigues, Thais Bonifácio Campolina, Rafael Nacif-Pimenta, Ana Clara Araújo Machado Pires, Ademir Bentes Vieira Júnior, Andréia da Costa Paz, Evelyn Beatriz da Costa Vaz, Maria das Graças Vale Barbosa Guerra, Breno Melo Silva, Fabrício Freire de Melo, Douglas Eric Norris, Marcus Vinícius Guimarães de Lacerda, Paulo Filemon Paolucci Pimenta, Nágila Francinete Costa Secundino
Background: Several tropical cities are permissive to Aedes aegypti and DENV endemicity, and have allowed for invasion and circulation of ZIKV in the same areas. People living in endemic regions have been simultaneously infected with two or more arboviruses. Methods: Ae. aegypti mosquitoes from Manaus, capital city of the Amazonas State, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results: Ae...
April 6, 2018: Journal of Infectious Diseases
Ann C Miller, Viktoria Livchits, Faiz Ahmad Khan, Sidney Atwood, Sergei Kornienko, Yulia Kononenko, Irina Vasilyeva, Salmaan Keshavjee
Background: We report the association of the FAST (Find cases Actively, Separate safely and Treat effectively) strategy with reduction of hospital-based acquisition of MDR-TB in Russian Federation. Methods: We used pre- and post-intervention cohorts in two Russian hospitals to determine whether the FAST strategy was associated with reduced odds of converting from known baseline isoniazid and rifampin (H/R) susceptibility to MDR within 12 months. Results: Sixty-three (8...
April 5, 2018: Journal of Infectious Diseases
Ekta Lachmandas, Ana B Rios-Miguel, Valerie A C M Koeken, Eva van der Pasch, Vinod Kumar, Vicky Matzaraki, Yang Li, Marije Oosting, Leo A B Joosten, Richard A Notebaart, Mahdad Noursadeghi, Mihai G Netea, Reinout van Crevel, Gabriele Pollara
Cellular metabolism can influence host immune responses to Mycobacterium tuberculosis (Mtb). Using a systems biology approach, differential expression of 292 metabolic genes involved in glycolysis, glutathione, pyrimidine and inositol phosphate pathways was evident at the site of a human tuberculin skin test challenge in patients with active tuberculosis infection. For 28 metabolic genes, we identified single nucleotide polymorphisms (SNPs) that were trans-acting for in vitro cytokine responses to Mtb stimulation, including glutathione and pyrimidine metabolism genes that alter production of Th1 and Th17 cytokines...
April 3, 2018: Journal of Infectious Diseases
Magelda Montoya, Matthew Collins, Wanwisa Dejnirattisai, Leah C Katzelnick, Henry Puerta-Guardo, Ramesh Jadi, Samuel Schildhauer, Piyada Supasa, Sirijitt Vasanawathana, Prida Malasit, Juthathip Mongkolsapaya, Aruna D de Silva, Hasitha Tissera, Angel Balmaseda, Gavin Screaton, Aravinda M de Silva, Eva Harris
Background: The four dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies and plasma from DENV-immune donors can neutralize or enhance ZIKV in vitro and in small animal models, and vice versa, the extent, duration, and significance of cross-reactivity remains unknown, particularly in flavivirus-endemic regions. Methods: We studied neutralizing antibodies to ZIKV and DENV1-4 in longitudinal serologic specimens through 3 years post-infection from people in Latin America and Asia with laboratory-confirmed DENV infections...
April 2, 2018: Journal of Infectious Diseases
Kathryn B Anderson, Timothy P Endy, Stephen J Thomas
No abstract text is available yet for this article.
April 2, 2018: Journal of Infectious Diseases
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