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Journal of Infectious Diseases

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https://www.readbyqxmd.com/read/28666374/genomic-epidemiology-of-a-major-mycobacterium-tuberculosis-outbreak-retrospective-cohort-study-in-a-low-incidence-setting-using-sparse-time-series-sampling
#1
Dorte Bek Folkvardsen, Anders Norman, Åse Bengård Andersen, Erik Michael Rasmussen, Lars Jelsbak, Troels Lillebaek
Since 1992, Denmark has documented the largest outbreak of tuberculosis in Scandinavia ascribed to a single genotype, termed 'C2/1112-15'. As of spring 2017, the International Reference Laboratory of Mycobacteriology in Copenhagen has collected and identified isolates from more than a thousand cases belonging to this outbreak via routine MIRU-VNTR typing. Here, we present a retrospective analysis of the C2/1112-15 dataset, based on whole-genome data from a sparse time-series consisting of five randomly selected isolates from each of the 23 years...
June 28, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28666370/assessment-of-hiv-screening-tests-for-pre-exposure-prophylaxis-programs
#2
Constance Delaugerre, Guillemette Antoni, Nadia Mahjoub, Gilles Pialoux, Eric Cua, Armelle Pasquet, Nolwenn Hall, Cécile Tremblay, Laurent Cotte, Catherine Capitant, Marie-Laure Chaix, Laurence Meyer, Jean-Michel Molina
Pre-exposure prophylaxis programs involve frequent HIV testing. We evaluated the sensitivity of HIV-diagnostic tests (two immunoassays antigen/antibody ARCHITECT and BIOPLEX and three rapid-tests VIKIA®-HIV1/2, AUTOTEST-VIH®, Determine® HIV1/2Ag/Ab Combo). Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, 2 were detected only with HIV-1-RNA. Sensitivity of ARCHITECT and BIOPLEX was 83% (95%CI: 76-99) and 82% (95%CI: 63-94), respectively. The sensitivity of the VIKIA, AUTOTEST and ALERE tests was 54% (95%CI: 34-72), 50% (95%CI: 31-69) and 78% (95%CI: 58-91), respectively...
June 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28658935/minimal-impact-by-antenatal-subpatent-p-falciparum-infections-on-delivery-outcomes-in-malawian-women-a-cohort-study
#3
Steve M Taylor, Mwayiwawo Madanitsa, Kyaw-Lay Thwai, Carole Khairallah, Linda Kalilani-Phiri, Anna M van Eijk, Victor Mwapasa, Feiko O Ter Kuile, Steven R Meshnick
Antenatal malaria screening with a rapid diagnostic test (RDT) and treatment only of RDT-positive women may potentially prevent low birthweight resulting from malaria. The consequences of subpatent antenatal infections below the detection limit of RDTs are incompletely understood. In Malawi, pregnant women of any gravidity were tested at each antenatal visit for P. falciparum using RDT and PCR and followed until delivery. Associations between antenatal infections and delivery outcomes were assessed with Poisson regression or ANOVA...
June 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28651350/targeting-an-essential-component-of-gram-positive-type-iv-secretion-systems-involved-in-gene-transfer-kills-2-birds-with-1-stone
#4
Guido Werner
No abstract text is available yet for this article.
June 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28645190/pcr-rflp-on-the-rdna-cannot-unequivocally-assign-ascaris-to-species-level-or-identify-hybrids
#5
Peter Nejsum, Martha Betson, Russell Stothard
No abstract text is available yet for this article.
June 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28645162/reply-to-nejsum-et-al
#6
Jeba R J Jesudoss Chelladurai, Matthew T Brewer
No abstract text is available yet for this article.
June 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633457/an-ha-stem-antibody-medi8852-prevents-and-controls-disease-and-limits-transmission-of-pandemic-influenza-viruses
#7
C I Paules, S Lakdawala, J M McAuliffe, M Paskel, L Vogel, N L Kallewaard, Q Zhu, K Subbarao
Background: MEDI8852 is a novel MAb which neutralizes both group I and group II influenza A viruses (IAV) in vitro. We evaluated whether MEDI8852 was effective for prophylaxis and therapy against representative group I (H5N1) and group II (H7N9) pandemic IAV in mice and ferrets and could be used to block transmission of influenza H1N1pdm09 in ferrets, compared to an irrelevant control MAb R347 and oseltamivir. Results: MEDI8852 was effective for prophylaxis and treatment of H7N9 and H5N1 infection in mice, with a clear dose-dependent response and treatment with MEDI8852 24, 48 or 72 h post-infection (hpi) was superior to oseltamivir for H5N1...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633455/fetal-metabolic-stress-disrupts-immune-homeostasis-and-induces-pro-inflammatory-responses-in-hiv-1-and-cart-exposed-infants
#8
Johannes C Schoeman, Gontse P Moutloatse, Amy C Harms, Rob J Vreeken, Henriette J Scherpbier, Liesbeth Van Leeuwen, Taco W Kuijpers, Carools J Reinecke, Ruud Berger, Thomas Hankemeier, Madeleine J Bunders
Increased morbidity and fetal growth restriction are reported in uninfected children born to HIV-1-infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress skewing the cell's immune response and restricting (cell) growth. Novel metabolomic techniques provided the opportunity to investigate the impact of fetal HIV-1 and combination ARV therapy (cART)-exposure on the infants' immune-metabolome. Peroxidized lipids, generated by reactive oxygen species, were increased in cART/HIV-1-exposed infants, indicating altered mitochondrial functioning...
June 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633488/viral-diagnostics-only-half-the-battle
#9
Angela R Branche, Ann R Falsey
No abstract text is available yet for this article.
June 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633319/immunotherapy-targeting-adenosine-synthase-a-decreases-severity-of-staphylococcus-aureus-infection-in-mouse-model
#10
Bao-Zhong Zhang, JianPiao Cai, Bin Yu, Lifeng Xiong, Qiubin Lin, Xiao-Yan Yang, Chen Xu, SongYue Zheng, Richard Yi-Tsun Kao, Konghung Sze, Kwok-Yung Yuen, Jian-Dong Huang
Staphylococcus aureus (S. aureus) is a severe pathogen found in the community and in hospitals. Most notably, Methicillin-resistant S. aureus (MRSA) is resistant to almost all antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. Previous research showed that S. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. In this study, we investigated adenosine synthase A (AdsA), a S...
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633308/prior-season-vaccination-and-risk-of-influenza-during-the-2014-2015-season-in-the-u-s
#11
Jessie R Chung, Brendan Flannery, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson, Joshua G Petrie, Emily T Martin, Arnold S Monto, Huong Q McLean, Edward A Belongia, Manjusha Gaglani, Alicia M Fry
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633301/reply-to-chung-et-al
#12
Danuta M Skowronski, Catharine Chambers, Gaston De Serres
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633285/chronic-kidney-disease-in-the-aging-human-immunodeficiency-virus-infected-population
#13
Jeffrey B Kopp
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28633282/editorial-host-attractiveness-and-malaria-transmission-to-mosquitoes
#14
Lauren Cator
No abstract text is available yet for this article.
June 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28605553/pyruvate-kinase-and-fc-gamma-receptor-gene-copy-numbers-associated-with-malaria-phenotypes
#15
Imad Faik, Hoang van Tong, Bertrand Lell, Christian G Meyer, Peter G Kremsner, Thirumalaisamy P Velavan
Genetic factors are associated with susceptibility to many infectious diseases and may be determinants of clinical progression. Gene copy number variation (CNV) has been shown to be associated with phenotypes of numerous diseases, including malaria. We quantified gene copy numbers of the pyruvate kinase, liver and red blood cells (PKLR) gene as well as of the Fcγ receptor 2A and Fcγ receptor 2C (FCGR2A, FCGR2C) and Fcγ receptor 3 (FCGR3) genes using real-time quantitative PCR (RT-qPCR) assays in Gabonese children with severe (n=184) or and mild (n=189) malaria and in healthy Gabonese and Caucasian individuals (n=76 each)...
June 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28605544/functional-analysis-reveals-geographical-variation-in-inhibitory-immune-responses-against-a-polymorphic-malaria-antigen
#16
Amy K Bei, Ambroise D Ahouidi, Jeffrey D Dvorin, Kazutoyo Miura, Ababacar Diouf, Daouda Ndiaye, Zul Premji, Mahamadou Diakite, Souleymane Mboup, Carole A Long, Manoj T Duraisingh
Background: PfRh2b is a P. falciparum invasion ligand that is a potential blood stage vaccine candidate antigen; however, a naturally occurring deletion within an immunogenic domain is present at high frequencies in Africa and has been associated with alternative invasion pathway usage. Standardized tools that provide antigenic specificity in in vitro assays are needed to functionally assess the neutralizing potential of humoral responses against malaria vaccine candidate antigens. Methods: Transgenic parasite lines were generated to express the PfRh2b deletion...
June 9, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28595330/contribution-of-progranulin-to-protective-lung-immunity-during-bacterial-pneumonia
#17
Shan Zou, Qin Luo, Zhixin Song, Liping Zhang, Yun Xia, Huajian Xu, Yu Xiang, Yibing Yin, Ju Cao
Background.: Progranulin (PGRN) is an important immunomodulatory factor in a variety of inflammatory diseases. However, its role in pulmonary immunity against bacterial infection remains unknown. Methods.: Pneumonia was induced in PGRN-deficient and normal wild-type mice using Pseudomonas aeruginosa or Staphylococcus aureus, and we assessed the effects of PGRN on survival, bacterial burden, cytokine and chemokine production, and pulmonary leukocyte recruitment after bacterial pneumonia...
June 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28591790/asian-g6pd-mahidol-reticulocytes-sustain-normal-plasmodium-vivax-development
#18
Germana Bancone, Benoit Malleret, Rossarin Suwanarusk, Nongnud Chowwiwat, Cindy S Chu, Rose McGready, Laurent Rénia, François Nosten, Bruce Russell
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder in humans and appears to be protective against falciparum severe malaria. Controversially, it is also thought that Plasmodium vivax has driven the recent selection of G6PD alleles. We use an experimental approach to determine whether G6PD-MahidolG487A variant, a widespread cause of severe G6PD deficiency in Southeast Asia, provides a barrier against vivax malaria. Our results show that the immature reticulocytes (CD71+) targeted by P...
June 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28591778/sustained-immunogenicity-of-2-dose-human-papillomavirus-16-18-as04-adjuvanted-vaccine-schedules-in-girls-aged-9-14-years-a-randomized-trial
#19
Li-Min Huang, Thanyawee Puthanakit, Chiu Cheng-Hsun, Tang Ren-Bin, Tino Schwarz, Angelo Pellegrino, Susanna Esposito, Louise Frenette, Shelly McNeil, Paolo Durando, Paul Rheault, Carlo Giaquinto, Michael Horn, Karl Ulrich Petry, Klaus Peters, Toma Azhar, Peter Hillemanns, Stephanie De Simoni, Damien Friel, Suryakiran Pemmaraju, Marjan Hezareh, Florence Thomas, Dominique Descamps, Nicolas Folschweiller, Frank Struyf
Background.: We previously reported the noninferiority 1 month after the last dose of 2-dose human papillomavirus 16/18 AS04-adjuvanted (AS04-HPV-16/18) vaccine schedules at months 0 and 6 (2D_M0,6) and months 0 and 12 (2D_M0,12) in girls aged 9-14 years compared with a 3-dose schedule at months 0, 1, and 6 (3D_M0,1,6) in women aged 15-25 years. Here, we report the results at study end (month 36 [M36]). Methods.: Girls were randomized 1:1 and received 2 vaccine doses either 6 months (2D_M0,6) or 12 months apart (2D_M0,12); women received 3 doses at months 0, 1, and 6 (3D_M0,1,6)...
June 7, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28586473/exome-sequencing-identifies-two-variants-of-the-alkylglycerol-monooxygenase-gene-agmo-as-a-cause-of-relapses-in-visceral-leishmaniasis-in-children-in-sudan
#20
Sandrine Marquet, Bruno Bucheton, Camille Reymond, Laurent Argiro, Sayda Hassan El-Safi, Musa Mohamed Kheir, Jean-Pierre Desvignes, Christophe Béroud, Adil Mergani, Awad Hammad, Alain J Dessein
Background.: Visceral leishmaniasis (Kala-azar, KA) is the most severe form of leishmaniasis, characterized by fever, weight loss, hepatosplenomegaly and lymphadenopathy. During an outbreak of KA in Babar El Fugara (Sudan), 5.7% of cured patients displayed relapses, with familial clustering in half of the cases. Methods.: We performed whole-exome sequencing on 10 relapsing individuals and 11 controls from five nuclear families. Results.: Rare homozygous and compound-heterozygous nonsense (c...
June 6, 2017: Journal of Infectious Diseases
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