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Journal of Hepatology

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https://www.readbyqxmd.com/read/28636900/re-global-trends-and-predictions-in-hepatocellular-carcinoma-mortality
#1
LETTER
Paola Bertuccio, Federica Turati, Greta Carioli, Teresa Rodriguez, Carlo La Vecchia, Matteo Malvezzi, Eva Negri
No abstract text is available yet for this article.
June 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28636899/author-s-reply-to-inappropriate-use-of-fib-4-index-for-cirrhosis-detection-in-hepatocellular-carcinoma-patients
#2
LETTER
Maneerat Chayanupatkul, Fasiha Kanwal
No abstract text is available yet for this article.
June 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28636898/author-s-reply-to-hepatocellular-carcinoma-hcc-in-the-absence-of-cirrhosis-in-patients-with-chronic-hepatitis-b-virus-infection
#3
LETTER
Maneerat Chayanupatkul, Fasiha Kanwal
No abstract text is available yet for this article.
June 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28636897/inappropriateuse-of-fib-4-index-for-cirrhosis-detection-in-hepatocellular-carcinoma-patients
#4
LETTER
Qing Pang, Hui-Chun Liu, Lei Zhou, Hao Jin
No abstract text is available yet for this article.
June 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28629790/current-therapeutic-approaches-for-hbv-infected-patients
#5
Upkar S Gill, Patrick T F Kennedy
No abstract text is available yet for this article.
June 16, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28627363/effect-of-interferon-based-and-free-therapy-on-early-occurrence-and-recurrence-of-hepatocellular-carcinoma-in-chronic-hepatitis-c
#6
Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina, Ayako Sato, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Toshihiko Nouchi, Hideki Sakai, Makoto Tomita, Mamoru Watanabe
BACKGROUND AND AIMS: Although treatment for hepatitis C virus has dramatically improved by the development of direct-acting antiviral agents (DAAs), whether interferon (IFN)-free therapy reduces hepatocarcinogenesis in an equivalent manner to IFN-based therapy remains controversial. The aims of this study were to evaluate the occurrence and recurrence of hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients treated with DAAs and to identify biomarkers of HCC development after antiviral treatment...
June 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28627362/how-to-predict-global-trends-in-hcc-mortality-if-neglect-more-than-half-the-world-s-cases
#7
LETTER
Li-Yang Sun, Han Zhang, Zhen-Li Li, Chao Li, Ming-Da Wang, Tian Yang
No abstract text is available yet for this article.
June 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28619439/origin-prevalence-and-response-to-therapy-of-hepatitis-c-virus-genotype-2k-1b-chimeras
#8
Simone Susser, Julia Dietz, Bernhard Schlevogt, Eli Zuckerman, Mira Barak, Valeria Piazzolla, Anita Howe, Holger Hinrichsen, Sandra Passmann, Rasha Daniel, Markus Cornberg, Alessandra Mangia, Stefan Zeuzem, Christoph Sarrazin
BACKGROUND & AIMS: Little is known about the epidemiology and frequency of recombinant HCV genotype 2/1 strains which may represent a challenge for direct antiviral therapy (DAA). METHODS: Consecutive samples from HCV genotype 2 infected patients from Germany, Italy and Israel according to commercial genotyping were re-genotyped by Sanger-based sequencing. Virologic, epidemiological, and phylogenetic analyses including other published chimeras were performed. RESULTS: Sequence analysis of 442 supposed HCV genotype 2 isolates revealed 61 (genotype 2k/1b (n=59), 2a/1b (n=1) or 2b/1a (n=1)) chimeras...
June 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28601675/non-selective-beta-blocking-of-aclf
#9
LETTER
T Reiberger, M Mandorfer
No abstract text is available yet for this article.
June 7, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28601674/the-relationship-between-age-and-fat-infiltration-in-liver-and-muscle
#10
LETTER
Giulia Dondi, Giulia Lancellotti, Marco Bertolotti, Chiara Mussi
No abstract text is available yet for this article.
June 7, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28600138/beta-adrenergic-blockade-and-advanced-cirrhosis-does-it-really-improve-survival-in-patients-with-acute-on-chronic-liver-failure
#11
LETTER
Georgios N Kalambokis, Gerasimos Baltayannis, Dimitrios Christodoulou, Leonidas Christou
No abstract text is available yet for this article.
June 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28600137/alternative-splicing-of-hepatitis-b-virus-a-novel-virus-host-interaction-altering-liver-immunity
#12
Marion Duriez, Yassmina Mandouri, Bouchra Lekbaby, Hualin Wang, Aurélie Schnuriger, Francois Redelsperger, Chiara Guerrera, Marine Lefevre, Veronique Fauveau, James Ahodantin, Ivan Quetier, Cerina Chhuon, Samir Gourari, Alexandre Boissonas, Upkar Gill, Patrick Kennedy, Nabil Debzi, Delphine Sitterlin, Mala K Maini, Dina Kremsdorf, Patrick Soussan
BACKGROUND & AIMS: Hepatitis B virus (HBV) RNA can undergo alternative splicing but the relevance of this post-transcriptional regulation remains elusive. Here, the mechanism of HBV alternative splicing regulation and its impact on liver pathogenesis were investigated. METHODS: HBV RNA-interacting proteins were identified by RNA pull-down combined to mass spectrometry analysis. HBV splicing regulation was investigated in chemically and surgically induced liver damage in whole HBV genome transgenic mice and in hepatoma cells...
June 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28596111/high-fat-diet-disrupts-endoplasmic-reticulum-calcium-homeostasis-in-the-rat-liver
#13
Emily S Wires, Kathleen A Trychta, Susanne Bäck, Agnieszka Sulima, Kenner C Rice, Brandon K Harvey
BACKGROUND & AIMS: Disruption to endoplasmic reticulum (ER) calcium homeostasis has been implicated in obesity, however, the ability to longitudinally monitor ER calcium fluctuations has been challenging with prior methodologies. We recently described the development of a Gaussia luciferase (GLuc)- based reporter protein responsive to ER calcium depletion (GLuc-SERCaMP) and investigated the effect of a high fat diet on ER calcium homeostasis. METHODS: A GLuc-based reporter cell line was treated with palmitate, a free fatty acid (FFA)...
June 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28596110/crosstalk-between-type-ii-nkt-cells-and-t-cells-leads-to-spontaneous-chronic-inflammatory-liver-disease
#14
Xiufang Weng, Ying He, Lavanya Visvabharathy, Chia-Min Liao, Xiaosheng Tan, Arjun Balakumar, Chyung-Ru Wang
BACKGROUND & AIM: NKT cells are CD1d-restricted innate-like T cells that modulate innate and adaptive immune responses. Unlike the well-characterized invariant/type I NKT cells, type II NKT cells with a diverse TCR repertoire are poorly understood. This study defines the pathogenic role of type II NKT cells in the etiology of chronic liver inflammation. METHODS: Transgenic mice with the Lck promoter directing CD1d overexpression on T cells in Jα18 wild-type (Lck-CD1dTgJα18(+); type I NKT cell sufficient) and Jα18-deficient (Lck-CD1dTgJα18(o), type I NKT cell deficient) mice were analyzed for liver pathology and crosstalk between type II NKT cells and conventional T cells...
June 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28596109/cytotherapy-with-m1-polarized-macrophages-ameliorates-liver-fibrosis-by-modulating-immune-microenvironment-in-mice
#15
Peng-Fei Ma, Chun-Chen Gao, Jing Yi, Jun-Long Zhao, Shi-Qian Liang, Yang Zhao, Yu-Chen Ye, Jian Bai, Qi-Jun Zheng, Ke-Feng Dou, Hua Han, Hong-Yan Qin
BACKGROUND & AIMS: Macrophages play vital roles in chronic liver injury, and have been tested as a tool for cytotherapy of liver fibrosis. However, macrophages possess ontogenic and functional heterogeneities. Some subsets are pro-fibrotic, whereas others are anti-fibrotic. This study aimed at clarifying which macrophage subset is efficient in cytotherapy of liver fibrosis and the underlying mechanisms. METHODS: Liver fibrosis was induced in mice by carbon tetrachloride (CCl4) injection or bile duct ligation (BDL)...
June 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28554875/cd39-limits-p2x7-receptor-inflammatory-signaling-and-attenuates-sepsis-induced-liver-injury
#16
Luiz Eduardo Baggio Savio, Paola de Andrade Mello, Vanessa R Figliuolo, Thiago F de Avelar Almeida, Patrícia T Santana, Suellen D S Oliveira, Claudia L M Silva, Linda Feldbrügge, Eva Csizmadia, Richard D Minshall, Maria Serena Longhi, Yan Wu, Simon C Robson, Robson Coutinho-Silva
BACKGROUND & AIMS: The severity of sepsis can be linked to excessive inflammatory responses resulting in hepatic injury with progressive cholestasis. Monocyte/macrophages have been linked to the pathogenesis of cholestasis, cellular injury, and liver failure. P2X7 receptor activation by extracellular ATP (eATP) exacerbates inflammation by augmenting cytokine production; while CD39 scavenges eATP to generate adenosine, thereby limiting P2X7 activation and resulting in A2A receptor stimulation...
May 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28554874/free-cholesterol-accumulation-in-liver-sinusoidal-endothelial-cells-exacerbates-acetaminophen-hepatotoxicity-via-tlr9-signaling
#17
Toshiaki Teratani, Kengo Tomita, Takahiro Suzuki, Hirotaka Furuhashi, Rie Irie, Shigeaki Hida, Yoshikiyo Okada, Chie Kurihara, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Hidetsugu Saito, Toshifumi Hibi, Soichiro Miura, Ryota Hokari, Takanori Kanai
BACKGROUND & AIMS: Although obesity is a risk factor for acute liver failure, the pathogenic mechanisms are not yet fully understood. High cholesterol (HC) intake, which often underlies obesity, is suggested to play a role in the mechanism. We aimed to elucidate the effect of HC diet on acetaminophen-induced acute liver injury, the most frequent cause of acute liver failure in the USA. METHODS: C57BL/6 Toll-like receptor 9 (TLR9) knockout (Tlr9(-/-)) mice and their Tlr9(+/+) littermates were fed an HC diet for 4 weeks and then treated with acetaminophen...
May 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28619256/pre-natal-and-post-natal-environment-monitoring-to-prevent-non-alcoholic-fatty-liver-disease-development
#18
EDITORIAL
Anna Alisi, Pietro Vajro
No abstract text is available yet for this article.
May 24, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28549917/dendritic-cell-derived-exosomes-elicit-tumor-regression-in-autochthonous-hepatocellular-carcinoma-mouse-models
#19
Zhen Lu, Bingfeng Zuo, Renwei Jing, Xianjun Gao, Quan Rao, Zhili Liu, Han Qi, Hongxing Guo, HaiFang Yin
BACKGROUND & AIMS: Dendritic cell (DC)-derived exosomes (DEXs) form a new class of vaccines for cancer immunotherapy. However their potency in hepatocellular carcinoma (HCC), a life-threatening malignancy with limited treatment options in the clinic and responds poorly to immunotherapy, remains to be investigated. METHODS: Exosomes derived from α-fetoprotein (AFP) - expressing DCs (DEXAFP) were investigated in three different HCC mouse models systemically and tumor growth and microenvironment were monitored...
May 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28619255/infant-nutrition-and-maternal-obesity-influence-the-risk-of-non-alcoholic-fatty-liver-disease-in-adolescents
#20
Oyekoya T Ayonrinde, Wendy H Oddy, Leon A Adams, Trevor A Mori, Lawrence J Beilin, Nicholas de Klerk, John K Olynyk
BACKGROUND & AIMS: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate knowledge regarding the associations between infant nutrition and subsequent NAFLD. We examined the association of maternal factors and infant nutrition, with the subsequent diagnosis of NAFLD in adolescents. METHODS: Adolescents aged 17years in the Western Australian Pregnancy (Raine) Cohort study had fatty liver assessment using liver ultrasound...
May 22, 2017: Journal of Hepatology
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