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Journal of Hepatology

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https://www.readbyqxmd.com/read/29031662/percutaneous-treatment-of-hepatocellular-carcinoma-state-of-the-art-and-innovations
#1
REVIEW
Jean-Charles Nault, Olivier Sutter, Pierre Nahon, Nathalie Ganne-Carrié, Olivier Séror
Percutaneous treatment of hepatocellular carcinoma (HCC) encompasses a vast range of techniques, including monopolar radiofrequency ablation (RFA), multibipolar RFA, microwave ablation, cryoablation and irreversible electroporation. RFA is considered to be one of the main curative treatments for HCC of less than 5 cm developing on cirrhosis, together with surgical resection and liver transplantation. However, controversies exist concerning the respective roles of ablation and liver resection for HCC of less than 3 to 5 cm on cirrhosis...
October 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29031907/about-cytokeratin-19-and-the-drivers-of-liver-regeneration
#2
EDITORIAL
Norman Junge, Amar Deep Sharma, Michael Ott
No abstract text is available yet for this article.
October 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29024699/-direct-antiviral-agents-and-risk-of-hcc-waiting-for-godot
#3
LETTER
Calogero Cammà, Gioacchino Leandro
No abstract text is available yet for this article.
October 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29024698/pediatric-clif-sofa-score-is-the-best-predictor-of-28-day-mortality-in-children-with-decompensated-chronic-liver-disease
#4
Rishi Bolia, Anshu Srivastava, Surender Kumar Yachha, Ujjal Poddar
BACKGROUND AND AIMS: Early identification of children with decompensated chronic liver disease (DCLD) at risk of short-term mortality helps improve outcome. We evaluated the predictors of outcome and role of Child Pugh [CP], Pediatric End- stage Liver Disease [PELD] and pediatric chronic liver failure sequential organ failure assessment [pCLIF-SOFA] score in prognosticating 28 days mortality in DCLD children. METHODS: DCLD children were prospectively evaluated with a clinico-laboratory proforma and followed till 28 days to determine outcome...
October 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29024697/reply-to-direct-antiviral-agents-and-risk-of-hcc-waiting-for-godot
#5
LETTER
Reem Waziry, Janaki Amin, Matthew Law, Gregory J Dore
No abstract text is available yet for this article.
October 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28993185/predicting-long-term-response-after-stopping-nucleos-t-ide-analogue-treatment-in-hbeag-negative-chronic-hepatitis-b
#6
LETTER
Thomas Berg, Jörg Petersen
No abstract text is available yet for this article.
October 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28993184/pitfalls-in-the-non-invasive-assessment-of-liver-fibrosis-with-elift-fm-vcte-algorithm
#7
LETTER
Xiao-Chen Wang, Xiao-Yu Zhang, Xin Zhang, Zhao-Xin Yuan, Xiu-Hui Li, Jin-Cheng Wang, Beicheng Sun, Xiao-Jie Lu
No abstract text is available yet for this article.
October 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28993183/nucleos-t-ide-analogue-interruption-alternative-approach-to-intrahepatic-set-point-for-spontaneous-control-of-hbv-replication
#8
LETTER
Yiqi Yu, Jing Wang, Guojun Li, Chuan Shen, Shaolong Chen, Jun Huang, Xinyu Wang, Caiyan Zhao, Yuxian Huang, Bin Wang, Xuanyi Wang, Jiming Zhang, Chao Qiu, Wenhong Zhang
No abstract text is available yet for this article.
October 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28989095/risk-factors-and-prevention-of-hepatocellular-carcinoma-in-the-era-of-precision-medicine
#9
REVIEW
Naoto Fujiwara, Scott L Friedman, Nicolas Goossens, Yujin Hoshida
Chronic fibrotic liver disease caused by viral or metabolic etiologies is a high-risk condition for developing hepatocellular carcinoma (HCC). Even after complete HCC tumor resection or ablation, the carcinogenic tissue microenvironment in the remnant liver can give rise to recurrent de novo HCC tumors, which progress into incurable, advanced-stage disease in the majority of patients. Thus, early detection and prevention of HCC development is, in principle, the most impactful strategy to improve patient prognosis...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28989094/impact-of-time-to-surgery-in-the-outcome-of-patients-with-liver-resection-for-bclc-0-a-stage-hepatocellular-carcinoma
#10
Chetana Lim, Prashant Bhangui, Chady Salloum, Concepción Gómez Gavara, Eylon Lahat, Alain Luciani, Philippe Compagnon, Julien Calderaro, Cyrille Feray, Daniel Azoulay
BACKGROUND & AIMS: The Barcelona Clinic Liver Cancer (BCLC) guidelines recommend resection for very early and early single hepatocellular carcinoma (HCC) patients. It is not known whether a delay in resection from the time of diagnosis (the time-to-surgery (TTS), i.e., the elapsed time from diagnosis to surgery) affects outcomes. We aim to evaluate the impact of TTS on the recurrence and survival outcomes. METHODS: All patients resected for BCLC stage 0-A single HCC from 2006 to 2016 were studied to evaluate the impact of TTS on recurrence rate, recurrence-free survival (RFS), transplantability following recurrence, and intention-to-treat overall survival (ITT-OS)...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28989093/durability-of-hepatitis-b-surface-antigen-seroclearance-in-untreated-and-nucleos-t-ide-analogue-treated-patients
#11
Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Yee-Kit Tse, Grace Chung-Yan Lui, Kelvin Long-Yan Lam, Henry Lik-Yuen Chan
BACKGROUND AND AIMS: It is uncertain if nucleos(t)ide analogues (NA)-induced hepatitis B surface antigen (HBsAg) seroclearance is durable. We investigated the impact of hepatitis B surface antibody (anti-HBs) and duration of consolidation antiviral therapy on the durability of HBsAg seroclearance. METHODS: A territory-widecohort study was conducted using data from the Hospital Authority, Hong Kong. We identified all subjects with positive HBsAg between January 1, 2000 and August 31, 2016...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28989092/advanced-liver-fibrosis-but-not-steatosis-is-independently-associated-with-albuminuria-in-chinese-patients-with-type-2-diabetes
#12
Ming-Wai Yeung, Grace Lai-Hung Wong, Kai Chow Choi, Andrea On-Yan Luk, Raymond Kwok, Sally She-Ting Shu, Anthony Wing-Hung Chan, Eric Siu Him Lau, Ronald Ching Wan Ma, Henry Lik-Yuen Chan, Juliana Chung-Ngor Chan, Vincent Wai-Sun Wong, Alice Pik-Shan Kong
BACKGROUND & AIMS: Increasing evidence suggests that non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for chronic kidney disease (CKD). Given the high prevalence of NAFLD among patients with diabetes who are also at risk for CKD, we aimed to investigate the association between NAFLD and albuminuria, a marker commonly found in diabetic nephropathy. METHODS: This study included a cohort of Chinese patients with type 2 diabetes from the Hong Kong Diabetes Registry recruited between March 2013 and May 2014...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28987520/retreatment-with-direct-acting-antivirals-of-genotypes-1-3-4-hepatitis-c-patients-who-failed-an-anti-ns5a-regimen-in-real-world
#13
LETTER
Philippe Halfon, Caroline Scholtès, Jacques Izopet, Sylvie Larrat, Pascale Trimoulet, Fabien Zoulim, Laurent Alric, Sophie Métivier, Vincent Leroy, Denis Ouzan, Victor de Lédinghen, Sofiane Mohamed, Guillaume Pénaranda, Hacène Khiri, Marie-Ange Thélu, Anne Plauzolles, Laurent Chiche, Marc Bourlière, Florence Abravanel
INTRODUCTION: The aim was to study retreatment according to baseline nonstructural protein 5A (NS5A) resistance-associated substitutions (RASs) after the failure of first-line DAA-based treatment. PATIENTS AND METHODS: From January 2014 to March 2016, 2995 HCV-infected patients were treated with NS5A inhibitors in six French liver referral centers; 80 (2.7%) patients relapsed. This "real-world" study included 24 of those 80 patients who had failed to achieve sustained virological response (SVR) on previous NS5A-based therapy...
October 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28987519/herbal-tea-consumption-and-the-liver-all-is-not-what-it-seems
#14
LETTER
Cyriac Abby Philips, Philip Augustine
No abstract text is available yet for this article.
October 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28987518/application-of-the-new-elift-test-for-the-non-invasive-diagnosis-of-advanced-liver-fibrosis-in-people-with-type-2-diabetes
#15
LETTER
Petit Jean Michel, Bouillet Benjamin, Loffroy Romaric, Rouland Alexias, Hillon Patrick, Verges Bruno
No abstract text is available yet for this article.
October 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28987517/screening-of-advanced-liver-fibrosis-one-step-at-a-time
#16
LETTER
Jérôme Boursier, Victor de Ledinghen, Vincent Leroy, Paul Calès
No abstract text is available yet for this article.
October 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28986102/reply-to-herbal-tea-consumption-and-the-liver-all-is-not-what-is-seems
#17
LETTER
Louise J M Alferink, Jessica C Kiefte-de Jong, Sarwa Darwish Murad
No abstract text is available yet for this article.
October 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28966126/controversies-in-clinical-trials-for-alcoholic-hepatitis
#18
Sarah R Lieber, John P Rice, Michael R Lucey, Ramon Bataller
Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease, contributing to significant morbidity and mortality. Yet, the only available therapies that improve survival are corticosteroids and liver transplantation with no new drugs successfully developed for decades. This article describes briefly the current state of affairs in AH therapy and examines the practical and ethical challenges to conducting controlled trials in patients with severe AH. While prednisolone is considered to be standard of care in severe AH, this recommendation remains controversial given the marginal benefits and questionable longterm safety of steroids...
September 28, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28966125/back-to-byzance-querelles-byzantines-over-nash-and-fibrosis
#19
EDITORIAL
Vlad Ratziu
No abstract text is available yet for this article.
September 28, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28964525/corrigendum-to-microrna-profiles-in-graft-preservation-solution-are-predictive-of-ischemic-type-biliary-lesions-after-liver-transplantation-j-hepatol-2013-59-1231-1238
#20
Cornelia J Verhoeven, Jasmijn W Selten, Henk P Roest, Waqar R R Farid, Petra E de Ruiter, Bettina E Hansen, Jeroen de Jonge, Jaap Kwekkeboom, Herold J Metselaar, Hugo W Tilanus, Geert Kazemier, Jan N M IJzermans, Luc J W van der Laan
No abstract text is available yet for this article.
September 27, 2017: Journal of Hepatology
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