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Journal of Hepatology

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https://www.readbyqxmd.com/read/28336466/global-trends-and-predictions-in-hepatocellular-carcinoma-mortality
#1
Paola Bertuccio, Federica Turati, Greta Carioli, Teresa Rodriguez, Carlo La Vecchia, Matteo Malvezzi, Eva Negri
BACKGROUND: Hepatocellular carcinoma (HCC) has been one of the few cancers showing upward trends over recent decades in most countries, and is the third cause of cancer death worldwide. PATIENTS AND METHODS: We updated global trends in HCC mortality to 2014, and predicted trends in rates in the EU, USA and Japan to 2020, using data from the World Health Organization database. RESULTS: In EU men, mortality rates were stable in the last decade around 3...
March 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323126/elita-consensus-statements-on-use-of-daas-in-liver-transplant-candidates-and-recipients
#2
REVIEW
Luca S Belli, Christophe Duvoux, Thomas Berg, Mario Strazzabosco, Stefano Fagiuoli, Saye Khoo, Georges Philippe Pageaux, Isabelle Colle, Massimo Puoti, Audrey Coilly, Didier Samuel, Marina Berenguer
The advent of safe and highly effective direct acting antivirals (DAA) had huge implications for the HCV transplant field and changed our management of both, patients on the waiting list and those with HCV graft reinfection after Liver Transplantation (LT). When treating HCV infection before LT, HCV reinfection of the graft may be prevented in nearly all patients. In addition some candidates show a remarkable clinical improvement and are possibly delisted. Alternatively, HCV infection can be treated post LT either soon after the transplant, taking advantage of the removal of the infected native liver, or at the time of disease recurrence as done in the past...
March 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323125/minocycline-hepatotoxicity-clinical-characterization-and-identification-of-hla-b%C3%A2-35-02-as-a-risk-factor
#3
Thomas Jacob Urban, Paola Nicoletti, Naga Chalasani, Jose Serrano, Andrew Stolz, Ann Daly, Guruprasad Aithal, John Dillon, Victor Navarro, Joseph Odin, Huiman Barnhart, David Ostrov, Nanye Long, Elizabeth Theresa Cirulli, Paul Brent Watkins, Robert John Fontana
BACKGROUND & AIMS: Minocycline hepatotoxicity can present with prominent autoimmune features in previously healthy individuals. The aim of this study was to identify genetic determinants of minocycline DILI in a well-phenotyped cohort of patients. METHODS: Caucasian patients with minocycline DILI underwent genome-wide genotyping and were compared to unexposed population controls. Human leukocyte antigen (HLA) binding of minocycline was assessed using AutoDock Vina...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323123/circumventing-intratumoral-heterogeneity-to-identify-potential-therapeutic-targets-in-hepatocellular-carcinoma
#4
Ao Huang, Xin Zhao, Xin-Rong Yang, Fu-Qiang Li, Xin-Lan Zhou, Kui Wu, Xin Zhang, Qi-Man Sun, Ya Cao, Hong-Mei Zhu, Xiang-Dong Wang, Huan-Ming Yang, Jian Wang, Zhao-You Tang, Yong Hou, Jia Fan, Jian Zhou
BACKGROUND AND AIMS: Intratumoral heterogeneity (ITH) challenges identifying mutations with target therapy potential whereas circulating cell-free DNAs (cfDNAs) in blood could possibly reflect the entire mutation spectrum in certain tumors. We investigated how to minimize the limit of ITH for profiling hepatocellular carcinoma (HCC). METHODS: Thirty-two multi-regional tumor samples from five patients were subjected to whole exome sequencing (WES) and targeted deep sequencing (TDS); matched preoperative cfDNAs were sequenced accordingly...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323122/exome-analysis-of-the-evolutionary-path-of-hepatocellular-adenoma-carcinoma-transition-vascular-invasion-and-brain-dissemination
#5
Sílvia Vilarinho, Zeynep Erson-Omay, Kisha Mitchell-Richards, Charles Cha, Carol Nelson-Williams, Akdes Serin Harmancı, Katsuhito Yasuno, Murat Günel, Tamar H Taddei
Hepatocellular adenoma (HCA) is a rare benign liver tumor, predominantly seen in young women. Its major complications are malignant transformation, spontaneous hemorrhage, and rupture. We describe a case of a young female with no underlying liver disease who presented with acute abdominal pain and was found to have a 17 cm heterogeneous mass in the left lobe of the liver. She underwent left hepatectomy and pathology revealed a 14 cm moderately differentiated hepatocellular carcinoma (HCC) arising in a shell of a HCA...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323121/the-treatment-of-intermediate-stage-tumour-beyond-tace-from-surgery-to-systemic-therapy
#6
REVIEW
Peter R Galle, Francesco Tovoli, Friedrich Foerster, Marcus A Wörns, Alessandro Cucchetti, Luigi Bolondi
Intermediate stage hepatocellular carcinoma (HCC) comprises the largest subgroup of patients with this disease and is characterized by substantial heterogeneity. Functional liver impairment, total tumour burden and other prognostic factors such as high alpha-fetoprotein serum level, presence of micro-vascular invasion, and poorly differentiated tumours relevantly contribute to outcome. The usage of the standard therapeutic approach, transarterial chemoembolization - TACE, for all intermediate stage HCC patients is probably an over-simplification and may therefore not be appropriate for all patients...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323120/how-to-eliminate-hcv-infection-by-antiviral-treatment
#7
EDITORIAL
Natasha K Martin, Peter Vickerman, Matthew Hickman
No abstract text is available yet for this article.
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28323124/cd44-is-a-key-player-in-non-alcoholic-steatohepatitis
#8
Stéphanie Patouraux, Déborah Rousseau, Stéphanie Bonnafous, Cynthia Lebeaupin, Carmelo Luci, Clémence M Canivet, Anne-Sophie Schneck, Adeline Bertola, Marie-Christine Saint-Paul, Antonio Iannelli, Jean Gugenheim, Rodolphe Anty, Albert Tran, Béatrice Bailly-Maitre, Philippe Gual
BACKGROUND: CD44 is expressed on many immune cells that contribute to inflammation. It has been shown, mainly through animal data, that CD44 regulates adipose tissue inflammation in obesity and hepatic leukocyte recruitment in a lithogenic context. However, its role in hepatic inflammation in a mouse model of steatohepatitis and its relevance in humans have not yet been investigated. METHODS: The role of CD44 was evaluated in CD44-/- mice and after injections of an αCD44 antibody in Wild-type mice challenged with a methionine- and choline-deficient diet (MCDD)...
March 16, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28315712/serum-hbsag-kinetics-in-clinical-prediction
#9
LETTER
Wen-Juei Jeng, Yun-Fan Liaw
No abstract text is available yet for this article.
March 15, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28315711/how-good-is-hepatitis-b-surface-antigen-kinetics-informing-strategy-to-stop-antiviral-therapy
#10
LETTER
Maurizia Brunetto, Markus Cornberg, Henry Lik Yuen Chan
No abstract text is available yet for this article.
March 15, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28315710/mrecist-for-systemic-therapies-more-evidence-is-required-before-recommendations-could-be-made
#11
LETTER
Julien Edeline, Daniel Palmer, Jean-Frédéric Blanc, Boris Campillo-Gimenez, Philippe Merle, Tim Meyer
No abstract text is available yet for this article.
March 15, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28315709/reply-to-mrecist-for-systemic-therapies-more-evidence-is-required-before-recommendations-could-be-made
#12
LETTER
Robert Montal, Riccardo Lencioni, Josep M Llovet
No abstract text is available yet for this article.
March 15, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28302383/erratum-to-corrigendum-to-signal-transducer-and-activator-of-transcription-3-is-a-major-kinase-independent-target-of-sorafenib-in-hepatocellular-carcinoma
#13
Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Hsiang-Po Huang, Jui-Wen Huang, Pei-Jer Chen, Kuen-Feng Chen
No abstract text is available yet for this article.
March 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28284917/assessment-of-treatment-efficacy-in-hepatocellular-carcinoma-response-rate-delay-in-progression-or-none-of-them
#14
EDITORIAL
Jordi Bruix, Maria Reig, Bruno Sangro
No abstract text is available yet for this article.
March 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28284916/infusion-of-mesenchymal-stromal-cells-after-deceased-liver-transplantation-a-phase-i-ii-open-label-clinical-study
#15
Olivier Detry, Morgan Vandermeulen, Marie-Hélène Delbouille, Joan Somja, Noella Bletard, Alexandra Briquet, Chantal Lechanteur, Olivier Giet, Etienne Baudoux, Muriel Hannon, Frederic Baron, Yves Beguin
BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the feasibility, safety and tolerability of a single infusion of MSCs in liver transplant recipients. METHODS: Ten liver transplant recipients under standard immunosuppression received 1.5-3x10(6)/kg third-party unrelated MSCs on post-operative day 3±2, and were prospectively compared to a control group of 10 liver transplant recipients...
March 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28284915/reversibility-of-chemotherapy-related-liver-injury
#16
Luca Vigano, Giovanni De Rosa, Christian Toso, Axel Andres, Alessandro Ferrero, Arnaud Roth, Elisa Sperti, Pietro Majno, Laura Rubbia-Brandt
BACKGROUND: Chemotherapy-related liver injury (CALI) increase the risk of liver resection and may prejudice further surgery and chemotherapy. CALI's reversibility is thus relevant; however, no data concerning this are available. We therefore retrospectively analyzed the reversibility of CALI in patients undergoing liver resection for colorectal metastases. METHODS: All resections of colorectal liver metastases after oxaliplatin and/or irinotecan-based chemotherapy were included...
March 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28284450/erratum-to-prognosis-of-patients-with-chronic-hepatitis-b-in-france-2008-2013-a-nationwide-observational-and-hospital-based-study
#17
Vincent Mallet, Kamal Hamed, Michaël Schwarzinger
No abstract text is available yet for this article.
March 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28283248/corrigendum-to-second-generation-direct-acting-antivirals-do-we-expect-major-improvements
#18
Jordan J Feld, Graham R Foster
No abstract text is available yet for this article.
March 7, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28267623/thymic-nf-%C3%AE%C2%BAb-inducing-kinase-nik-regulates-cd4-t-cell-elicited-liver-injury-and-fibrosis-in-mice
#19
Hong Shen, Liang Sheng, Yi Xiong, Yeung-Hyen Kim, Lin Jiang, Zheng Chen, Yong Liu, Kalyani Pyaram, Cheong-Hee Chang, Liangyou Rui
BACKGROUND & AIMS: The liver is an immunologically-privileged organ. Breakdown of liver immune privilege has been reported in chronic liver disease; however, the role of adaptive immunity in liver injury is poorly defined. NIK is known to regulate immune tissue development, but its role in maintaining liver homeostasis remains unknown. This study aimed to assess the role of NIK, particularly thymic NIK, in regulating liver adaptive immunity. METHODS: NIK was deleted systemically or conditionally using the cre/loxp system...
March 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28267622/effectiveness-of-hepatitis-c-antiviral-treatment-in-a-usa-cohort-of-veteran-patients-with-hepatocellular-carcinoma
#20
Lauren A Beste, Pamela K Green, Kristin Berry, Matthew J Kogut, Stephen K Allison, George N Ioannou
BACKGROUND & AIMS: Hepatitis C virus (HCV) treatment for patients with hepatocellular carcinoma (HCC) was uncommon before direct acting antiviral (DAA) medications. Real-world effectiveness of DAAs for HCV in patients with HCC is unclear. We describe rates of sustained virologic response (SVR) with DAA regimens by HCV genotype in patients with history of HCC. METHODS: We identified patients who initiated antiviral treatment between January 1, 2014 and June 30, 2015 in the national Veterans Affairs health care system...
March 3, 2017: Journal of Hepatology
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