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Journal of Hepatology

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https://www.readbyqxmd.com/read/28219772/evidence-based-recommendations-on-the-management-of-extrahepatic-manifestations-of-chronic-hepatitis-c-virus-infection
#1
REVIEW
Manuel Ramos-Casals, Anna Linda Zignego, Clodoveo Ferri, Pilar Brito-Zerón, Soledad Retamozo, Milvia Casato, Peter Lamprecht, Alessandra Mangia, David Saadoun, Athanasios G Tzioufas, Zobair M Younossi, Patrice Cacoub
∗The current therapeutic armamentarium against HCV has been recently expanded with an explosion of new molecules (DAAs) with high virological efficacy ∗The objective of this international consensus is to provide therapeutic recommendations for HCV patients with extrahepatic manifestations (EHM). ∗The use of non-antiviral therapeutic approaches should be evaluated according to the type of EHM and severity of the clinical presentation ∗B cell depletion with rituximab is the established biologic approach to cryoglobulinaemic vasculitis (CV) employed to date...
February 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28219771/developing-a-new-algorithm-to-diagnose-advanced-liver-fibrosis-a-lift-or-a-nudge-in-the-right-direction
#2
EDITORIAL
Leon A Adams, Richard K Sterling
No abstract text is available yet for this article.
February 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28215599/reply-to-tools-and-tactics-for-improving-diagnosis-of-hepatic-encephalopathy
#3
LETTER
Sara Montagnese, Michele De Rui, Paolo Angeli, Piero Amodio
No abstract text is available yet for this article.
February 16, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28215598/tools-and-tactics-for-improving-diagnosis-of-hepatic-encephalopathy
#4
LETTER
Søren S Olesen, Clive D Jackson, Marsha Y Morgan
No abstract text is available yet for this article.
February 16, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28215597/ripk1-a-key-survival-factor-for-hepatocytes
#5
EDITORIAL
Camille Blériot, Marc Lecuit
No abstract text is available yet for this article.
February 16, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28213165/hbvcircle-a-novel-tool-to-investigate-hepatitis-b-virus-covalently-closed-circular-dna
#6
Zhipeng Yan, Jing Zeng, Youjun Yu, Kunlun Xiang, Hui Hu, Xue Zhou, Lili Gu, Li Wang, Jie Zhao, John A T Young, Lu Gao
BACKGROUND & AIMS: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) persists as a stable episome in infected hepatocytes and serves as a template for the transcription of all viral genes. Due to the narrow host range of HBV, the development of a robust mouse model that supports cccDNA-dependent viral replication is a key hurdle in the development of novel HBV therapeutics. This study aimed to develop a novel tool to investigate HBV cccDNA. METHODS: Through minicircle technology, HBVcircle, a recombinant cccDNA, was easily generated and extracted from a genetically engineered E...
February 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28213164/carvedilol-use-is-associated-with-improved-survival-in-patients-with-liver-cirrhosis-and-ascites
#7
Rohit Sinha, Khalida A Lockman, Nethmee Mallawaarachchi, Marcus Robertson, John N Plevris, Peter C Hayes
BACKGROUND AND AIMS: Carvedilol, a non-selective beta-blocker (NSBB) with additional anti-alpha 1 receptor activity, is a potent portal hypotensive agent. It has been used as prophylaxis against variceal bleed. However, its safety in decompensated liver cirrhosis with ascites is still disputed. In this study, we examined whether long-term use of carvedilol in the presence of ascites is a risk factor for mortality. METHODS: This was a single-centre retrospective analysis of 325 consecutive patients with liver cirrhosis and ascites presenting to our Liver Unit between 1(st) of January 2009 to 31(st) August 2012...
February 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28223101/non-invasive-evaluation-of-portal-hypertension-using-ultrasound-elastography
#8
REVIEW
Annalisa Berzigotti
Portal hypertension (PH) leads to serious complications such as bleeding from gastro-esophageal varices, ascites and porto-systemic encephalopathy in patients with chronic liver disease (CLD). Since the gold-standard methods for assessing PH and its complications (measurement of hepatic venous pressure gradient, HVPG; endoscopy), are invasive expensive and not available at all centers, non-invasive methods have been increasingly investigated in the last 20 years. The present review focuses on the role of ultrasound elastography, a novel group of non-invasive techniques able to measure stiffness in target organs, to identify the presence, severity and risk of complications of PH...
February 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28223100/focus-on-the-liver-host-virus-interactions-in-hbv
#9
EDITORIAL
Thomas Vanwolleghem, Andre Boonstra
No abstract text is available yet for this article.
February 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28192190/%C3%AE-7-integrin-and-madcam-1-play-opposing-roles-during-the-development-of-non-alcoholic-steatohepatitis
#10
Hannah K Drescher, Angela Schippers, Thomas Clahsen, Hacer Sahin, Heidi Noels, Mathias Hornef, Norbert Wagner, Christian Trautwein, Konrad L Streetz, Daniela C Kroy
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease in western countries. It is unclear how infiltrating leukocytes affect NASH-development. Hence our study aims to investigate the role of the homing/receptor-pair mucosal addressin cell adhesion molecule-1 (MAdCAM-1)/β7-Integrin for immune cell recruitment and disease progression in a steatohepatitis model. METHODS: Constitutive β7-Integrin deficient (β7(-/-)) and MAdCAM-1 deficient (MAdCAM-1(-/-)) mice were fed high-fat-diet (HFD) for 26 weeks or methionine-choline-deficient-diet (MCD) for 4 weeks...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28192189/mir-425-regulates-inflammatory-cytokine-production-in-cd4-t-cells-via-n-ras-upregulation-in-primary-biliary-cholangitis
#11
Ryo Nakagawa, Ryosuke Muroyama, Chisato Saeki, Kaku Goto, Yoshimi Kaise, Kazuhiko Koike, Masanori Nakano, Yasuo Matsubara, Keiko Takano, Sayaka Ito, Masayuki Saruta, Naoya Kato, Mikio Zeniya
BACKGROUND & AIM: Primary biliary cholangitis (PBC) is an autoimmune liver disease of unknown pathogenesis. Consequently, therapeutic targets for PBC have yet to be identified. Because CD4(+) T cells play a pivotal role in immunological dysfunction observed in PBC, we analysed microRNA (miRNA) and mRNA expression in CD4(+) T cells to investigate PBC pathogenesis and identify novel therapeutic targets. METHODS: We performed integral miRNA and mRNA analysis of 14 PBC patients and 10 healthy controls using microarray and quantitative real time polymerase chain reaction (qRT-PCR) with gene set enrichment analysis...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28192188/hepatitis-c-virus-induced-nk-cell-activation-causes-metzincin-mediated-cd16-cleavage-and-impaired-antibody-dependent-cytotoxicity
#12
Barbara Oliviero, Stefania Mantovani, Stefania Varchetta, Dalila Mele, Giulia Grossi, Serena Ludovisi, Elisa Nuti, Armando Rossello, Mario U Mondelli
BACKGROUND & AIMS: The Fc receptor family for IgG type III (FcγRIII, CD16) is an activating receptor on natural killer (NK) cells and an essential mediator of antibody-dependent cellular cytotoxicity (ADCC). There is only limited information on its role during chronic hepatitis C virus (HCV) infection. We studied CD16 expression in relation to NK cell functional activity in HCV-infected patients and sought mechanistic insights into virus-induced modulation. METHODS: NK cell CD16 expression and activation status were evaluated ex vivo by flow cytometry in HCV-infected patients and healthy controls (HC) as well as in vitro after co-culture with HCV-infected Huh 7...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28192187/hepatic-atrophy-following-preoperative-chemotherapy-predicts-hepatic-insufficiency-after-resection-of-colorectal-liver-metastases
#13
Suguru Yamashita, Junichi Shindoh, Takashi Mizuno, Yun Shin Chun, Claudius Conrad, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: For patients with colorectal liver metastases (CLM) undergoing major hepatectomy, extensive preoperative chemotherapy has been associated with increased morbidity and mortality. The impact of extensive chemotherapy on total liver volume (TLV) change is unclear. METHODS: Clinicopathological features of patients with CLM who underwent preoperative chemotherapy and curative resection were reviewed (2008-2015). TLV change (degree of atrophy) was defined as the percentage difference of TLV (estimated by manual volumetry)/standardized liver volume (SLV) ratio: ([Pre-chemotherapy TLV] - [Post-chemotherapy TLV]) × 100 ÷ SLV (%)...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28192186/elevated-expression-of-erbin-destabilizes-er%C3%AE-protein-and-promotes-tumorigenesis-in-hepatocellular-carcinoma
#14
Hua Wu, Su Yao, Shen Zhang, Jing-Ru Wang, Peng-Da Guo, Xiu-Ming Li, Wen-Juan Gan, Lin Mei, Tian-Ming Gao, Jian-Ming Li
BACKGROUND & AIMS: Aberrant estrogen receptor-α (ERα) expression and signaling are implicated in the development of hepatocellular carcinoma (HCC), but its regulation in HCC remains enigmatic. Herein, we aimed to identify a new mechanism by which ERα signaling is regulated in HCC, which may lead to a potential new strategy for HCC therapy. METHODS: Expression levels of' Erbin and ERα in human HCC samples were evaluated by immunohistochemistry. In vitro and in vivo experiments were used to assess the effect of Erbin and ERα signaling on HCC cells growth...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28192185/hepatic-decompensation-is-the-major-driver-of-death-in-hcv-infected-cirrhotic-patients-with-successfully-treated-early-hepatocellular-carcinoma
#15
Giuseppe Cabibbo, Salvatore Petta, Marco Barbara, Simona Attardo, Laura Bucci, Fabio Farinati, Edoardo G Giannini, Giulia Negrini, Francesca Ciccarese, Gian Lodovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Rodolfo Sacco, Roberto Virdone, Fabio Andrea Marra Mega, Filomena Morisco, Luisa Benvegnù, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco Giuseppe Foschi, Andrea Olivani, Alberto Masotto, Gerardo Nardone, Antonio Colecchia, Marcello Persico, Antonio Craxì, Franco Trevisani, Calogero Cammà
BACKGROUND & AIMS: A major problem in assessing the long-term outcome of HCV-infected cirrhotic patients with successfully treated Barcelona Clinic Liver Cancer (BCLC) A hepatocellular carcinoma (HCC) arises from the lack of models accounting for early changes during follow-up. AIM: of study is to estimate the impact on 5-year overall survival (OS) of early (occurring within 12 months after complete radiological response) time-dependents events (HCC recurrence or hepatic decompensation) in a large cohort of successfully treated HCC patients with HCV cirrhosis...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28189756/actomyosin-contractility-drives-bile-regurgitation-as-an-early-response-during-obstructive-cholestasis
#16
Kapish Gupta, Qiushi Li, Jun Jun Fan, Eliza Li Shan Fong, Ziwei Song, Shupei Mo, Haoyu Tang, Inn Chuan Ng, Chan Way Ng, Pornteera Pawijit, Shuangmu Zhuo, Chen-Yuan Dong, Boon Chuan Low, Aileen Wee, Yock Young Dan, Pakorn Kanchanawong, Peter So, Virgile Viasnoff, Hanry Yu
BACKGROUND & AIMS: A wide range of liver diseases manifest as biliary obstruction, or cholestasis. However, the sequence of molecular events triggered as part of the early hepatocellular homeostatic response in obstructive cholestasis is poorly elucidated. Bile canaliculi are dynamic luminal structures that undergo actomyosin-mediated periodic contractions to propel secreted bile. Additionally, pericanalicular actin is known to accumulate during obstructive cholestasis. Therefore, we hypothesize that the pericanalicular actin cortex undergoes significant remodeling as a regulatory response to obstructive cholestasis...
February 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28189755/mice-species-specific-control-of-hepatocarcinogenesis-and-metabolism-by-fgf19-fgf15
#17
Mei Zhou, Jian Luo, Michael Chen, Hong Yang, R Marc Learned, Alex M DePaoli, Hui Tian, Lei Ling
BACKGROUND & AIMS: Bile acid nuclear receptor farnesoid X receptor (FXR) is a key molecular mediator of many metabolic processes, including the regulation of bile acid, lipid and glucose homeostasis. A significant component of FXR-mediated events essential to its biological activity is attributed to induction of the enteric endocrine hormone FGF19 or its rodent ortholog, FGF15. In this report, we compare the properties of human FGF19 and murine FGF15 in the regulation of hepatocarcinogenesis and metabolism in various mouse models of disease...
February 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28189754/generic-ledipasvir-sofosbuvir-for-patients-with-chronic-hepatitis-c-a-real-life-observational-study
#18
Qing-Lei Zeng, Guang-Hua Xu, Ji-Yuan Zhang, Wei Li, Da-Wei Zhang, Zhi-Qin Li, Hong-Xia Liang, Chun-Xia Li, Zu-Jiang Yu
BACKGROUND & AIMS: Few patients from developing countries can afford brand name direct-acting antiviral agents for treatment of hepatitis C virus (HCV) infection, and controversy regarding the bioequivalence of generics exists. This study aimed to observe the safety and efficacy of 8 or 12 weeks of generic ledipasvir-sofosbuvir with or without ribavirin for Chinese genotype 1b HCV-infected patients. METHODS: In this open-labelled observational study, 63 cirrhotic (group 1) and 65 non-cirrhotic (group 2) patients were administered generic ledipasvir-sofosbuvir plus 1,000-1,200 mg of ribavirin daily for 12 and 8 weeks, respectively; and 64 non-cirrhotic patients (group 3) received ledipasvir-sofosbuvir for 8 weeks...
February 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28189753/detecting-liver-fat-from-viscoelasticity-how-good-is-cap-in-clinical-practice-the-need-for-universal-cut-offs
#19
EDITORIAL
Manuel Romero-Gómez, Helena Cortez-Pinto
No abstract text is available yet for this article.
February 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28189752/real-world-treatment-for-chronic-hepatitis-c-infection-in-germany-analyses-from-drug-prescription-data-2010-2015
#20
Ruth Zimmermann, Christian Kollan, Patrick Ingiliz, Stefan Mauss, Daniel Schmidt, Viviane Bremer
BACKGROUND: Direct-acting Hepatitis C antivirals (DAAs) have strongly improved treatment options since 2014, but it is unclear if treatment numbers increased. We aimed to estimate the number of treatment regimens/month from 2010-2015, the number of patients treated and cured with DAAs since 2014 and associated costs. METHODS: Drug-prescription data of HCV-antivirals for patients with statutory health-insurance in Germany (∼85% of population) were evaluated from 01/2010-12/2015...
February 8, 2017: Journal of Hepatology
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