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Journal of Hepatology

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https://www.readbyqxmd.com/read/28807831/note-of-caution-contaminations-of-hepatocellular-cell-lines
#1
EDITORIAL
Sandra Rebouissou, Jessica Zucman-Rossi, Richard Moreau, Zhixin Qiu, Lijian Hui
No abstract text is available yet for this article.
August 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28803954/performance-status-in-patients-with-hcc-new-kid-on-the-block
#2
LETTER
Teh-Ia Huo, Chia-Yang Hsu, Po-Hong Liu
No abstract text is available yet for this article.
August 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28803953/fibrosis-stage-but-not-nash-predicts-mortality-and-time-to-development-of-severe-liver-disease-in-biopsy-proven-nafld
#3
Hannes Hagström, Patrik Nasr, Mattias Ekstedt, Ulf Hammar, Per Stål, Rolf Hultcrantz, Stergios Kechagias
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is highly common in the general population, but identifying patients with increased risk for mortality and liver-specific morbidity remains a challenge. Non-alcoholic steatohepatitis (NASH) is thought to enhance this risk; therefore, resolution of NASH is a major endpoint in current pharmacologic studies. METHODS: We conducted a retrospective cohort study of 646 biopsy-proven NAFLD patients. Each case was matched for age, sex and municipality to ten controls...
August 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28803952/performance-status-in-patients-with-hcc-new-kid-on-the-block-or-reunion-with-an-old-friend
#4
LETTER
Marcus-Alexander Wörns, Peter Robert Galle
No abstract text is available yet for this article.
August 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28803951/monocytes-inhibit-hepatitis-c-virus-induced-trail-expression-on-cd56-bright-nk-cells
#5
Dalila Mele, Stefania Mantovani, Barbara Oliviero, Giulia Grossi, Andrea Lombardi, Mario U Mondelli, Stefania Varchetta
BACKGROUND AND AIMS: Natural killer (NK) cells play an important role in the pathogenesis of HCV infection. We have previously shown that culture-derived HCV (HCVcc) enhance tumor necrosis-factor-related apoptosis-inducing ligand (TRAIL) expression on healthy but not on HCV-infected patient-derived NK cells, which was likely dependent on accessory cells. Here we sought mechanistic insights involved in altered TRAIL upregulation in this setting. METHODS: Peripheral blood mononuclear cells (PBMC) from controls and HCV-infected patients were exposed to HCVcc...
August 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28803950/interferon-free-therapy-of-hepatitis-c-during-wait-list-and-post-transplant-risk-of-hepatocellular-carcinoma-recurrence
#6
LETTER
Maria Francesca Donato, Federica Invernizzi, Giorgio Rossi, Massimo Iavarone
No abstract text is available yet for this article.
August 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28802877/declining-mortality-in-critically-ill-patients-with-cirrhosis-in-australia-and-new-zealand-between-2000-and-2015
#7
Avik Majumdar, Michael Bailey, William M Kemp, Rinaldo Bellomo, Stuart K Roberts, David Pilcher
BACKGROUND AND AIMS: Few studies have described the outcomes of patients with cirrhosis receiving intensive care unit (ICU) admission at a population level. We aimed to describe trends in the mortality of such patients in Australia and New Zealand (ANZ), and to investigate the relationship with associated organ failures. METHODS: We studied patients admitted to 172 ICUs on a non-elective basis, with and without cirrhosis between January 1(st) 2000 and December 31(st) 2015 as recorded by the ANZ Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database...
August 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28802876/hepatocellular-carcinoma-risk-following-direct-acting-antiviral-hcv-therapy-a-systematic-review-meta-analyses-and-meta-regression
#8
Reem Waziry, Behzad Hajarizadeh, Jason Grebely, Janaki Amin, Matthew Law, Mark Danta, Jacob George, Gregory J Dore
BACKGROUND: Risk of hepatocellular carcinoma (HCC) occurrence or recurrence following direct-acting antiviral (DAA) HCV therapy remains unclear. The aims of this study were: 1) In patients with HCV-related cirrhosis, to compare the rate of HCC occurrence following DAA versus interferon (IFN)-based cure, and; 2) In patients who received curative HCC treatment, to compare rate of HCC recurrence following DAA versus IFN-based cure. METHODS: A search was conducted for reports published between January 2000 and February 2017...
August 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28802875/primary-sclerosing-cholangitis-a-comprehensive-review
#9
REVIEW
Tom H Karlsen, Trine Folseraas, Douglas Thorburn, Mette Vesterhus
Primary sclerosing cholangitis (PSC) is a rare disorder characterized by multi-focal bile duct strictures and progressive liver disease. Inflammatory bowel disease (IBD) is usually present and there is a high risk of cholangiocarcinoma and colorectal cancer. With no effective medical therapy, most patients ultimately require liver transplantation, after which disease recurrence may occur. With limited therapeutic options and lack of proven surveillance strategies, patients experience significant unmet needs...
August 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28800877/reply-to-interferon-free-therapy-of-hepatitis-c-during-wait-list-and-post-transplant-risk-of-hepatocellular-carcinoma-recurrence
#10
LETTER
Ju Dong Yang, Michael D Leise
No abstract text is available yet for this article.
August 8, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28797582/is-room-temperature-susceptometry-really-an-accurate-method-to-assess-hepatocellular-iron-a-response
#11
LETTER
Mueller Sebastian, Mueller Johannes
No abstract text is available yet for this article.
August 7, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28789883/response-to-thalheimer-et-al-jhepat-d-17-00938r3
#12
LETTER
Mattias Mandorfer, Thomas Reiberger
No abstract text is available yet for this article.
August 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28789882/no-effect-of-resistance-associated-substitutions-in-patients-with-rare-hcv-subtypes-following-treatment-with-sofosbuvir-containing-regimens
#13
LETTER
Stefan Zeuzem, Hadas Dvory-Sobol, Diana M Brainard
No abstract text is available yet for this article.
August 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28789881/is-room-temperature-susceptometer-really-an-accurate-method-to-assess-hepatocellular-iron
#14
A Paisant, F Lainé, Y Gandon, E Bardou-Jacquet
No abstract text is available yet for this article.
August 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28789880/response-to-daa-therapy-in-the-nhs-england-early-access-programme-for-rare-hcv-subtypes-from-low-and-middle-income-countries
#15
LETTER
Ana da Silva Filipe, Vattipally Sreenu, Joseph Hughes, Elihu Aranday-Cortes, William L Irving, Graham R Foster, Kosh Agarwal, William Rosenberg, Douglas Macdonald, Paul Richardson, Mark A Aldersley, Martin Wiselka, Andrew Ustianowski, John McLauchlan, Emma C Thomson
No abstract text is available yet for this article.
August 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28789879/non-selective-beta-blockers-in-cirrhosis
#16
LETTER
Ulrich Thalheimer, Valerio Giannelli, Sergio Maimone
No abstract text is available yet for this article.
August 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28760329/micro-elimination-a-path-to-global-elimination-of-hepatitis-c
#17
EDITORIAL
Jeffrey V Lazarus, Stefan Wiktor, Massimo Colombo, Mark Thursz
No abstract text is available yet for this article.
July 28, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28596109/cytotherapy-with-m1-polarized-macrophages-ameliorates-liver-fibrosis-by-modulating-immune-microenvironment-in-mice
#18
Peng-Fei Ma, Chun-Chen Gao, Jing Yi, Jun-Long Zhao, Shi-Qian Liang, Yang Zhao, Yu-Chen Ye, Jian Bai, Qi-Jun Zheng, Ke-Feng Dou, Hua Han, Hong-Yan Qin
BACKGROUND & AIMS: Macrophages play vital roles in chronic liver injury, and have been tested as a tool for cytotherapy in liver fibrosis. However, macrophages possess ontogenic and functional heterogeneities. Some subsets are pro-fibrotic, whereas others are anti-fibrotic. This study aimed to clarify which macrophage subset is efficient for cytotherapy in liver fibrosis and to elucidate the underlying mechanisms. METHODS: Liver fibrosis was induced in mice by carbon tetrachloride injection or bile duct ligation...
July 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28778687/hepatitis-b-cure-from-discovery-to-regulatory-approval
#19
REVIEW
Anna S Lok, Fabien Zoulim, Geoffrey Dusheiko, Marc G Ghany
The majority of persons currently treated for chronic hepatitis B require long-term or lifelong therapy. New inhibitors of hepatitis B virus entry, replication, assembly, or secretion and immune modulatory therapies are in development. The introduction of these novel compounds for chronic hepatitis B necessitates a standardised appraisal of the efficacy and safety of these treatments and definitions of new or additional endpoints to inform clinical trials. To move the field forward and to expedite the pathway from discovery to regulatory approval, a workshop with key stakeholders was held in September 2016 to develop a consensus on treatment endpoints to guide the design of clinical trials aimed at hepatitis B cure...
July 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28739112/reactivation-of-hepatitis-b-virus-from-an-isolated-anti-hbc-positive-patient-after-eradication-of-hepatitis-c-virus-with-direct-acting-antiviral-agents
#20
LETTER
Tsuyoshi Suda, Tetsuro Shimakami, Takayoshi Shirasaki, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
No abstract text is available yet for this article.
July 21, 2017: Journal of Hepatology
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