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Journal of Hepatology

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https://www.readbyqxmd.com/read/28716745/gut-derived-endotoxin-stimulates-factor-viii-secretion-from-endothelial-cells-implications-for-hypercoagulability-in-cirrhosis
#1
Carnevale Roberto, Raparelli Valeria, Nocella Cristina, Bartimoccia Simona, Novo Marta, Severino Anna, De Falco Elena, Cammisotto Vittoria, Pasquale Chiara, Crescioli Clara, Sili Scavalli Antonio, Riggio Oliviero, Basili Stefania, Violi Francesco
BACKGROUND & AIMS: Patients with cirrhosis display enhanced blood levels of factor VIII, which may result in harmful activation of the clotting system; however, the underlying mechanism is unknown. METHODS: We performed a cross-sectional study in cirrhotic patients (n=61) and matched controls (n=61) comparing blood levels of factor VIII, von Willebrand factor (vWf), lipopolysaccharide (LPS) and positivity for Escherichia Coli DNA. Furthermore, we performed an in-vitro study to investigate if LPS, in a range of concentration similar to that found in the peripheral circulation of cirrhotic patients, was able to elicit factor VIII secretion from human umbilical vein endothelial cells (HUVEC)...
July 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28716744/a-heterozygous-mutation-in-got1-is-associated-with-familial-macro-aspartate-aminotransferase
#2
Maria Kulecka, Aldona Wierzbicka, Agnieszka Paziewska, Michal Mikula, Andrzej Habior, Wojciech Janczyk, Michalina Dabrowska, Jakub Karczmarski, Michal Lazniewski, Krzysztof Ginalski, Anna Czlonkowska, Piotr Socha, Jerzy Ostrowski
BACKGROUND & AIMS: Macro-aspartate aminotransferase (macro-AST) manifests as persistent elevation of AST levels, due to association of the protein with immunoglobulins in the circulation macro-AST is a rare, benign condition without a previously confirmed genetic basis. METHODS: Whole exome sequencing (WES)-based screening was performed on 32 participants with suspected familial macro-AST, while variants validation was performed on an extended cohort of 90 probands and 1644 healthy controls using Taqman genotyping...
July 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28712691/biliary-bile-acids-in-hepatobiliary-injury-what-is-the-link
#3
REVIEW
Peter Fickert, Martin Wagner
The main trigger for liver injury in acquired cholestatic liver disease remains unclear. However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in deciphering the pathomechanisms of inborn cholestatic liver diseases, decoding mechanisms of BA-induced cell death, and generating modern BA-derived drugs has improved the understanding of the regulation of BA synthesis and transport. Now is the appropriate time to reassess current knowledge about the specific role of BAs in hepatobiliary injury...
July 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28712690/gallstone-disease-optimal-timing-of-treatment
#4
Philipp-Robert Scherber, Frank Lammert, Matthias Glanemann
No abstract text is available yet for this article.
July 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28690178/fructrose-uric-acid-and-zonal-differences-in-nash
#5
LETTER
J P Mann, M J Armstrong
No abstract text is available yet for this article.
July 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28690177/author-s-reply-fructose-uric-acid-and-zonal-differences-in-nash
#6
LETTER
V Nobili, A Mosca, E Scorletti, C D Byrne
No abstract text is available yet for this article.
July 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28690176/evaluation-of-the-current-guidelines-for-resection-of-hepatocellular-carcinoma-using-the-appraisal-of-guidelines-research-and-evaluation-ii-instrument
#7
Pascal Gavriilidis, Keith J Roberts, Alan Askari, Robert P Sutcliffe, Teh-la Huo, Po-Hong Liu, Ernest Hidalgo, Philippe Compagnon, Chetana Lim, Daniel Azoulay
BACKGROUND & AIMS: Numerous guidelines for the management of HCC have been developed. The AGREE II is the only validated instrument to assess the methodological quality of guidelines. We aim to appraise the methodological quality of existing guidelines for the resection of hepatocellular carcinoma (HCC) using the Appraisal of Guidelines for Research & Evaluation (AGREE II) instrument. METHODS: Cochrane, Medline, Google scholar and Embase were searched using both PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria and free text...
July 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28690175/serum-metabolic-signatures-in-patients-with-overt-hepatic-encephalopathy
#8
LETTER
Sven Stengel, Andreas Stallmach, Klaus Richter, Andreas Landrock, Jochen Hampe, Tony Bruns
No abstract text is available yet for this article.
July 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28690174/clinical-outcomes-of-donation-after-circulatory-death-liver-transplantation-in-primary-sclerosing-cholangitis
#9
Palak J Trivedi, Irene Scalera, Emma Slaney, Richard W Laing, Bridget Gunson, Gideon M Hirschfield, Andrea Schlegel, James Ferguson, Paolo Muiesan
BACKGROUND AND AIM: Primary sclerosing cholangitis (PSC) is a progressive fibro-inflammatory cholangiopathy for which liver transplantation is the only life-extending intervention. These patients may benefit from accepting liver donation after circulatory death (DCD), however their subsequent outcome is unknown. METHODS: Clinical outcomes were prospectively evaluated in PSC patients undergoing transplantation from 2006 to 2016 stratified by donor type (DCD, n=35 vs...
July 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28688802/metabolic-signature-for-severe-cirrhosis-with-inflammation-or-hepatic-encephalopathy-do-we-really-face-two-different-entities
#10
LETTER
Nicolas Weiss, Benoit Colsch, François Fenaille, Christophe Junot, Dominique Thabut
No abstract text is available yet for this article.
July 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28687477/prognostic-factors-and-predictors-of-sorafenib-benefit-in-patients-with-hepatocellular-carcinoma-analysis-of-two-phase-3-studies
#11
Jordi Bruix, Ann-Lii Cheng, Gerold Meinhardt, Keiko Nakajima, Yoriko De Sanctis, Josep Llovet
BACKGROUND AND AIMS: Sorafenib, an oral multikinase inhibitor, significantly prolonged overall survival (OS) versus placebo in patients with unresectable hepatocellular carcinoma (HCC) in two phase 3 studies, SHARP (Sorafenib HCC Assessment Randomized Protocol) and Asia-Pacific (AP). To assess prognostic factors for HCC and predictive factors of sorafenib benefit, we conducted a pooled exploratory analysis from these placebo-controlled phase 3 studies. METHODS: To identify potential prognostic factors for OS, univariate and multivariate (MV) analyses were performed for baseline variables by Cox proportional hazards model...
July 4, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28684104/acid-base-disorders-in-liver-disease
#12
REVIEW
Scheiner Bernhard, Lindner Gregor, Reiberger Thomas, Schneeweiss Bruno, Trauner Michael, Zauner Christian, Funk Georg-Christian
Next to the kidneys and lungs, the liver has been recognized as an important regulator of acid-base homeostasis. While respiratory alkalosis is the most common acid-base disorder in chronic liver disease, various complex metabolic acid-base disorders may occur with liver dysfunction. Although the standard variables of acid-base equilibrium, such as pH and overall base excess, often fail to unmask the underlying cause of acid-base disorders, the physical-chemical acid-base model allows a more in-depth pathophysiological understanding and clinical judgement of acid-base disorders in patients with liver diseases...
July 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28684103/late-hepatitis-b-and-c-diagnosis-in-relation-to-disease-decompensation-and-hepatocellular-carcinoma-development
#13
Hasina Samji, Amanda Yu, Margot Kuo, Maryam Alavi, Ryan Woods, Maria Alvarez, Gregory J Dore, Mark Tyndall, Mel Krajden, Naveed Z Janjua
BACKGROUND AND AIMS: We measured the timing of HBV and HCV diagnoses relative to detection of decompensated cirrhosis (DC) and hepatocellular carcinoma (HCC) as an indicator of late hepatitis diagnosis. METHODS: HBV and HCV diagnoses were defined relative to the diagnosis of DC or HCC such that HBV/HCV diagnoses within two years prior, at the time of or after HCC or DC diagnosis were considered late. We performed multivariable logistic regression to assess factors associated with late HBV/HCV diagnoses among those with DC or HCC...
July 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28676324/norursodeoxycholic-acid-in-patients-with-primary-sclerosing-cholangitis-a-new-urso-saga-in-the-horizon
#14
EDITORIAL
Olivier Chazouillères
No abstract text is available yet for this article.
July 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28673770/alterations-of-the-nuclear-transport-system-in-hepatocellular-carcinoma-new-basis-for-therapeutic-strategies
#15
REVIEW
Martin Beck, Peter Schirmacher, Stephan Singer
Hepatocellular carcinoma (HCC) is among the most prevalent human malignancies world-wide with rising incidence in industrialized countries, few therapeutic options and poor prognosis. To expand and improve therapeutic strategies identification of drug targets ideally involved in several liver cancer relevant pathways appears mandatory. Virtually all signal transduction cascades cross the nuclear envelope and thereby require components of the nuclear transport system (NTS) including nuclear transport receptors (e...
June 30, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28669753/response-to-the-cochrane-systematic-review-on-daa-based-treatment-of-chronic-hepatitis-c
#16
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28668580/elevated-levels-of-circulating-osteopontin-are-associated-with-a-poor-survival-after-resection-of-cholangiocarcinoma
#17
Sven H Loosen, Christoph Roderburg, Katja L Kauertz, Inês Pombeiro, Catherine Leyh, Fabian Benz, Mihael Vucur, Thomas Longerich, Alexander Koch, Till Braunschweig, Tom F Ulmer, Christoph Heidenhain, Frank Tacke, Marcel Binnebösel, Maximilian Schmeding, Christian Trautwein, Ulf P Neumann, Tom Luedde
BACKGROUND& AIMS: Cholangiocarcinoma (CCA) represents a primary hepatic malignancy with a global rise in incidence and high mortality. Surgical treatment has remained the only potentially curative treatment option, but it is still unclear which patients benefit most from extended liver surgery, highlighting the need for new preoperative stratification strategies. Osteopontin is a secreted extracellular glyco-phosphoprotein that has been associated with inflammation, metabolic disorders and cancer...
June 28, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28662847/calreticulin-mutations-and-their-importance-in-budd-chiari-syndrome
#18
LETTER
Jain Abhinav, Tibdewal Pratik, Shukla Akash
No abstract text is available yet for this article.
June 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28662846/response-to-letter-calreticulin-mutations-and-their-importance-in-budd-chiari-syndrome
#19
LETTER
Johanne Poisson, Fanny Turon, Christophe Marzac, Dominique-Charles Valla, Juan-Carlos Garcia-Pagan, Pierre-Emmanuel Rautou
No abstract text is available yet for this article.
June 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28652084/impact-of-age-and-gender-on-risk-of-hepatocellular-carcinoma-after-hepatitis-b-surface-antigen-seroclearance
#20
Terry Cheuk-Fung Yip, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Yee-Kit Tse, Kelvin Long-Yan Lam, Grace Lai-Hung Wong
BACKGROUND AND AIMS: Previous studies suggested spontaneous seroclearance of hepatitis B surface antigen (HBsAg) after 50 years old was still associated with an increased risk of hepatocellular carcinoma (HCC). This study aimed to evaluate the risk of HCC after HBsAg seroclearance and the impact of gender on HCC. METHODS: All chronic hepatitis B patients under medical care in Hospital Authority, Hong Kong who have cleared HBsAg from January 2000 to August 2016 were identified...
June 23, 2017: Journal of Hepatology
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