journal
MENU ▼
Read by QxMD icon Read
search

Journal of Hepatology

journal
https://www.readbyqxmd.com/read/28438690/maturation-of-secreted-hcv-particles-by-incorporation-of-secreted-apoe-protects-from-antibodies-by-enhancing-infectivity
#1
Dorothea Bankwitz, Mandy Doepke, Kathrin Hueging, Romy Weller, Janina Bruening, Patrick Behrendt, Ji-Young Lee, Florian W R Vondran, Michael P Manns, Ralf Bartenschlager, Thomas Pietschmann
BACKGROUND & AIMS: Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from non-infected cells interacts with and modulates secreted HCV particles. METHODS: ApoE secreted from non-infected cells was incubated with HCV from primary human hepatocytes or Huh-7...
April 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28438689/non-coding-rna-in-hepatocellular-carcinoma-mechanisms-biomarkers-and-therapeutic-targets
#2
REVIEW
Marcel Klingenberg, Akiko Matsuda, Sven Diederichs, Tushar Patel
The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection of liver cancer as well as for the treatment of liver cancer.
April 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28438688/hepatitis-b-virus-reactivation-during-hepatitis-c-direct-acting-antiviral-therapy-in-patients-with-previous-hbv-infection
#3
LETTER
Naoki Kawagishi, Goki Suda, Masahiro Onozawa, Megumi Kimura, Osamu Maehara, Jyun Ito, Masato Nakai, Takuya Sho, Mitsuteru Natsuizka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
The frequency of HBV-reactivation in patients with previous HBV infection during DAA therapy has been not clarified. In present study, we found that 5.7% (5/87) of patients with previous HBV infection had experienced HBV-reactivation (n=1) or showed detectable HBV-DNA (n=4) during IFN-free DAA treatment. CLINICAL TRIAL NUMBER: UMIN000023366.
April 21, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28435043/carvedilol-and-survival-in-cirrhosis-with-ascites-a-cognitive-bias
#4
LETTER
Anderson Brito-Azevedo
No abstract text is available yet for this article.
April 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28435042/mesenchymal-stromal-cells-for-immunomodulatory-cell-therapy-in-liver-transplantation-one-step-at-a-time
#5
LETTER
Jordi Colmenero, Pau Sancho-Bru
No abstract text is available yet for this article.
April 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28435041/reply-to-the-letter-to-the-editor
#6
LETTER
Rohit Sinha, Khalida A Lockman, John N Plevris, Peter C Hayes
No abstract text is available yet for this article.
April 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28435040/response-to-the-letter-regarding-the-manuscript-survival-of-patients-with-hcv-cirrhosis-and-sustained-virologic-response-is-similar-to-the-general-population
#7
LETTER
Savino Bruno, Patrick Maisonneuve
No abstract text is available yet for this article.
April 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28435039/methodological-considerations-when-calculating-person-time-at-risk-for-patients-with-chronic-hepatitis-c-undergoing-antiviral-treatment
#8
LETTER
Sofie Hallager, Steen Ladelund, Nina Weis
No abstract text is available yet for this article.
April 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28427875/easl-2017-clinical-practice-guidelines-on-the-management-of-hepatitis-b-virus-infection
#9
Pietro Lampertico, Kosh Agarwal, Thomas Berg, Maria Buti, Harry L A Janssen, George Papatheodoridis, Fabien Zoulim, Frank Tacke
Hepatitis B virus (HBV) infection remains a global public health problem with changing epidemiology due to several factors including vaccination policies and migration. This Clinical Practice Guideline presents updated recommendations for the optimal management of HBV infection. Chronic HBV infection can be classified into five phases: (I) HBeAg-positive chronic infection, (II) HBeAg-positive chronic hepatitis, (III) HBeAg-negative chronic infection, (IV) HBeAg-negative chronic hepatitis and (V) HBsAg-negative phase...
April 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28427765/easl-clinical-practice-guidelines-the-diagnosis-and-management-of-patients-with-primary-biliary-cholangitis
#10
Gideon M Hirschfield, Ulrich Beuers, Christophe Corpechot, Pietro Invernizzi, David Jones, Marco Marzioni, Christoph Schramm
Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is usually based on the presence of serum liver tests indicative of a cholestatic hepatitis in association with circulating antimitochondrial antibodies. Patient presentation and course can be diverse and risk stratification is important to ensure all patients receive a personalised approach to their care. The goals of treatment and management are the prevention of end-stage liver disease, and the amelioration of associated symptoms...
April 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28427764/role-of-endoscopy-in-primary-sclerosing-cholangitis-european-society-of-gastrointestinal-endoscopy-esge-and-european-association-for-the-study-of-the-liver-easl-clinical-guideline
#11
(no author information available yet)
This guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE) and of the European Association for the Study of the Liver (EASL) on primary sclerosing cholangitis. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was adopted to define the strength of recommendations and the quality of evidence. Main recommendations.
April 13, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412296/impact-of-higher-order-heme-degradation-products-on-hepatic-function-and-hemodynamics
#12
Raphael A Seidel, Thierry Claudel, Franziska A Schleser, Navin K Ojha, Matthias Westerhausen, Sandor Nietzsche, Christoph Sponholz, Frans Cuperus, Sina M Coldewey, Stefan H Heinemann, Georg Pohnert, Michael Trauner, Michael Bauer
BACKGROUND& AIMS: While, traditionally, biliverdin and bilirubin are considered end products of heme catabolism, there is evidence for further degradation to diverse bioactive products. As such, Z-BOX A and Z-BOX B arise upon oxidation with unknown implications for hepatocellular function and integrity. We studied the impact of Z-BOX A and B on hepatic functions and explored their alterations in health and cholestatic conditions. METHODS: Functional implications and mechanisms were investigated in rats, hepatocytic HepG2 and HepaRG cells, human immortalized hepatocytes, and isolated perfused livers...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412295/evidence-for-a-role-of-genetics-in-alcoholic-hepatitis-data-from-the-stopah-randomized-controlled-trial
#13
EDITORIAL
Alexandre Louvet, Markus Peck-Radosavljevic
No abstract text is available yet for this article.
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412294/visualization-of-hepatitis-e-virus-rna-and-proteins-in-the-human-liver
#14
Daniela Lenggenhager, Jérôme Gouttenoire, Mohsen Malehmir, Marion Bawohl, Hanna Honcharova-Biletska, Susanne Kreutzer, David Semela, Jörg Neuweiler, Sandra Hürlimann, Patrick Aepli, Montserrat Fraga, Roland Sahli, Luigi Terracciano, Laura Rubbia-Brandt, Beat Müllhaupt, Christine Sempoux, Darius Moradpour, Achim Weber
BACKGROUND: / Aims: Although hepatitis E constitutes a substantial disease burden worldwide, surprisingly little is known about the localization of hepatitis E virus (HEV) in the human liver. We therefore aimed to visualize HEV RNA and proteins in situ. METHODS: A panel of 12 different antibodies against HEV open reading frame (ORF) 1-3 proteins was evaluated for immunohistochemistry (IHC) and two probes for in situ hybridization (ISH) in formalin-fixed, paraffin-embedded (FFPE) Huh-7 cells transfected with HEV ORF1-3 expression vectors...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412293/glecaprevir-and-pibrentasvir-yield-high-response-rates-in-patients-with-hcv-genotype-1-6-without-cirrhosis
#15
Paul Y Kwo, Fred Poordad, Armen Asatryan, Stanley Wang, David L Wyles, Tarek Hassanein, Franco Felizarta, Mark S Sulkowski, Edward Gane, Benedict Maliakkal, J Scott Overcash, Stuart C Gordon, Andrew J Muir, Humberto Aguilar, Kosh Agarwal, Gregory J Dore, Chih-Wei Lin, Ran Liu, Sandra S Lovell, Teresa I Ng, Jens Kort, Federico J Mensa
BACKGROUND: and Aims Hepatitis C virus (HCV) therapy that is highly efficacious, pangenotypic, with a high barrier to resistance and short treatment duration is desirable. The efficacy and safety of 8- and 12-week treatments with glecaprevir (ABT-493; NS3/4A protease inhibitor) and pibrentasvir (ABT-530; NS5A inhibitor) was evaluated in non-cirrhotic patients with chronic HCV genotype 1-6 infection. METHODS: SURVEYOR-I and SURVEYOR-II were phase 2, open-label, multicenter, dose-ranging trials including patients with chronic HCV genotype 1-6 infection who were either previously untreated or treated with pegylated interferon plus ribavirin...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412292/hla-bw4-80-t-and-multiple-hla-bw4-copies-combined-with-kir3dl1-associate-with-spontaneous-clearance-of-hcv-infection-in-people-who-inject-drugs
#16
Christine Thöns, Tina Senff, Theresa J Hydes, Angela R Manser, Falko M Heinemann, Andreas Heinold, Martin Heilmann, Arthur Y Kim, Markus Uhrberg, Norbert Scherbaum, Georg M Lauer, Salim I Khakoo, Jörg Timm
BACKGROUND AND AIMS: NK cell function is regulated by inhibitory and activating receptors including killer-cell immunoglobulin-like receptors (KIRs). Here, we analyzed the impact of different KIR/KIR-ligand genotypes on the outcome of HCV infection in people who inject drugs (PWID). KIR/KIR-ligand genotypes associated with spontaneous clearance of HCV infection were identified in a cohort of PWID from Germany (n=266) and further validated in a second anti-HCV positive cohort of PWID recruited in North America (n=342)...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412291/high-prices-or-missing-screening-strategy-why-do-daa-treatment-numbers-in-germany-decline
#17
LETTER
Ruth Zimmermann, Christian Kollan, Patrick Ingiliz, Stefan Mauss, Daniel Schmidt, Viviane Bremer
No abstract text is available yet for this article.
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28412290/lack-of-decline-in-hepatitis-c-virus-incidence-among-hiv-positive-men-who-have-sex-with-men-during-1990-2014
#18
Daniela Katinka Van Santen, Jannie Johanna Van Der Helm, Julia Del Amo, Laurence Meyer, Antonella D'arminio Monforte, Matt Price, Charles Antoine Béguelin, Robert Zangerle, Mette Sannes, Kholoud Porter, Ronald Bertus Geskus, Maria Prins
BACKGROUND AND AIMS: Hepatitis C virus (HCV) incidence among HIV-positive men who have sex with men (MSM) has increased since 2000, though regional differences have been documented in recent years. We aimed to 1) estimate trends in HCV incidence among HIV-positive MSM, 2) assess the association between incidence and geographical region, age and HIV-related measurements and, 3) assess temporal changes in time from HIV seroconversion to HCV infection. METHODS: We used data from MSM with well-estimated dates of HIV seroconversion from the CASCADE Collaboration (1990-2014)...
April 12, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28411042/negotiating-better-discounts-for-daa-therapy-is-critical-to-achieve-hcv-elimination-by-2030
#19
LETTER
Gregory J Dore, Jason Grebely
No abstract text is available yet for this article.
April 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28411041/in-hiv-hcv-co-infected-patients-t-regulatory-and-myeloid-derived-suppressor-cells-persist-after-successful-treatment-with-directly-acting-antivirals
#20
LETTER
Nicola Tumino, Rita Casetti, Gabriele Fabbri, Eleonora Cimini, Antonella Romanelli, Federica Turchi, Olindo Forini, Veronica Bordoni, Andrea Antinori, Adriana Ammassari, Alessandra Sacchi, Chiara Agrati
No abstract text is available yet for this article.
April 11, 2017: Journal of Hepatology
journal
journal
20153
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"