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Journal of Hepatology

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https://www.readbyqxmd.com/read/29891100/treatment-of-chronic-hepatitis-c
#1
Xavier Forns, Christoph Sarrazin
No abstract text is available yet for this article.
June 8, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29890192/is-obesity-a-risk-factor-for-the-development-of-acute-on-chronic-liver-failure-in-patients-with-decompensated-cirrhosis
#2
LETTER
Jiong-Jie Yu, Ju-Dong Li, Xin-Fei Xu, Feng Shen, Tian Yang
No abstract text is available yet for this article.
June 8, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29886157/regulation-of-epithelial-injury-and-bile-duct-obstruction-by-nlrp3-and-il-1r1-in-experimental-biliary-atresia
#3
Li Yang, Tatsuki Mizuochi, Pranavkumar Shivakumar, Reena Mourya, Zhenhua Luo, Sridevi Gutta, Jorge A Bezerra
BACKGROUND & AIMS: Biliary atresia (BA) results from a neonatal inflammatory and fibrosing obstruction of bile ducts of unknown etiology. Although the innate immune system has been linked to virus-induced mechanism of disease, the role of the inflammasome-mediated epithelial injury remains largely undefined. Here, we hypothesized that disruption of the inflammasome suppresses the neonatal proinflammatory response and prevents experimental BA. METHODS: We determined the expression of key inflammasome-related genes in livers from infants at diagnosis of BA and in extrahepatic bile ducts (EHBDs) of neonatal mice after infection with rotavirus (RRV) immediately after birth...
June 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29886156/modeling-nafld-disease-burden-in-china-france-germany-italy-japan-spain-united-kingdom-and-united-states-for-the-period-2016-2030
#4
Chris Estes, Quentin M Anstee, Maria Teresa Arias-Loste, Heike Bantel, Stefeno Bellentani, Joan Caballeria, Massimo Colombo, Antonio Craxi, Javier Crespo, Christopher P Day, Andreas Geier, Loreta A Kondili, Jeffrey V Lazarus, Rohit Loomba, Michael P Manns, Giulio Marchesini, Francesco Negro, Salvatore Petta, Vlad Ratziu, Manuel Romero-Gomez, Arun Sanyal, Jörn M Schattenberg, Frank Tacke, Christian Trautwein, Lai Wei, Stefan Zeuzem, Homie Razavi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) with resulting nonalcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis and hepatocellular carcinoma (HCC) globally. This burden is expected to increase as epidemics of obesity, diabetes and metabolic syndrome continue to grow. The goal of this analysis was to use a Markov model to forecast NAFLD disease burden using currently available data. METHODS: A model was used to estimate NAFLD and NASH disease progression in 8 countries based on data for adult prevalence of obesity and type 2 diabetes mellitus (DM)...
June 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29886155/multi-organ-assessment-of-compensated-cirrhosis-patients-using-quantitative-magnetic-resonance-imaging
#5
Christopher R Bradley, Eleanor F Cox, Robert A Scott, Martin W James, Phillip Kaye, Guruprasad P Aithal, Susan T Francis, Indra Neil Guha
BACKGROUND AND AIMS: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs in a single scan has implications for determining the balance of benefit versus harm for therapies. Our aim was to establish the feasibility of Magnetic Resonance Imaging to assess changes in compensated cirrhosis (CC), and relate this to disease severity and future liver related outcomes (LROs)...
June 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29886154/sofosbuvir-velpatasvir-for-12-weeks-in-genotype-1-4-hcv-infected-liver-transplant-recipients
#6
Kosh Agarwal, Lluís Castells, Beat Müllhaupt, William M C Rosenberg, Brian McNabb, Sarah Arterburn, Gregory Camus, John McNally, Luisa M Stamm, Diana M Brainard, G Mani Subramanian, Zoe Mariño, Jean-François Dufour, Xavier Forns
BACKGROUND & AIMS: Sofosbuvir, an NS5B inhibitor, combined with velpatasvir, an NS5A inhibitor (SOF/VEL), produces high sustained virologic response rates 12 weeks after treatment (SVR12) in patients with genotype 1-6 HCV infection, and has no anticipated clinically relevant drug-drug interactions with immunosuppressants. This study evaluated the safety and efficacy of SOF/VEL in adults with recurrent chronic genotype 1-4 HCV infection after liver transplant. METHODS: Patients received SOF/VEL 400/100 mg daily for 12 weeks...
June 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29885414/family-occurrence-of-autoimmune-hepatitis-a-danish-nationwide-registry-based-cohort-study
#7
Lisbet Grønbæk, Hendrik Vilstrup, Lars Pedersen, Kaare Christensen, Peter Jepsen
BACKGROUND AND AIMS: It is widely believed that autoimmune hepatitis accumulates in families, but the degree of familial clustering has not been clarified. We conducted a population-based study on the family occurrence of autoimmune hepatitis. METHODS: Through Danish nationwide registries we identified 8,582 first-degree and 9,230 second-degree relatives of index patients diagnosed with autoimmune hepatitis in 1994-2015; and 64 co-twins of index patients diagnosed with autoimmune hepatitis in 1977-2011...
June 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29885413/efficacy-of-annexin-a3-blockade-in-sensitizing-hepatocellular-carcinoma-to-sorafenib-and-regorafenib
#8
Man Tong, Noélia Che, Lei Zhou, Steve T Luk, Phillis W Kau, Stella Chai, Elly S Ngan, Chung-Mau Lo, Kwan Man, Jin Ding, Terence K Lee, Stephanie Ma
BACKGROUND & AIMS: Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. Sorafenib is the only FDA approved first-line targeted drug for advanced HCC, but its effect on patients' survival gain is limited. Further, patients ultimately present disease progression. A better understanding of causes of sorafenib resistance, enhancing the efficacy of sorafenib and finding a reliable predictive biomarker are crucial to achieve efficient control of HCC...
June 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29883596/karnofsky-performance-status-before-and-after-liver-transplantation-predicts-graft-and-patient-survival
#9
Paul J Thuluvath, Avesh J Thuluvath, Yulia Savva
BACKGROUND AND AIMS: The Karnofsky Performance Status (KPS) has been used for almost 70 years for clinical assessment of patients. Our objective was to determine whether KPS is an independent predictor of post-liver transplant (LT) survival after adjusting for known confounders. METHOD: Adult patients listed with UNOS from 2006 to 2016 were grouped patients into low (10-40%, n=15,103), intermediate (50-70%, n=22,183) and high (80-100%, n=13,131) KPS based on KPS scores at the time of LT after excluding those on ventilators or life support...
June 5, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29879455/hipsc-hepatocyte-model-demonstrates-the-role-of-unfolded-protein-response-and-inflammatory-networks-in-%C3%AE-1-antitrypsin-deficiency
#10
Charis-Patricia Segeritz, Sheikh Tamir Rashid, Miguel Cardoso de Brito, Maria Serra Paola, Adriana Ordonez, Carola Maria Morell, Joseph E Kaserman, Pedro Madrigal, Nicholas Hannan, Laurent Gatto, Lu Tan, Andrew A Wilson, Kathryn Lilley, Stefan J Marciniak, Bibekbrata Gooptu, David A Lomas, Ludovic Vallier
BACKGROUND AND AIMS: α1 -antitrypsin deficiency (A1ATD) is an autosomal recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant (Gly342Lys) retain polymerised protein in the endoplasmic reticulum (ER) of their hepatocytes, predisposing them to liver disease. The concomitant lack of circulating A1AT also causes lung emphysema. Greater insight into the mechanisms that link protein misfolding to liver injury will facilitate the design of novel therapies...
June 4, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29870764/feeding-the-hedgehog-a-new-meaning-for-jnk-signalling-in-liver-regeneration
#11
EDITORIAL
Salvatore Papa, Concetta Bubici
No abstract text is available yet for this article.
June 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29870763/reply-to-the-relationship-of-hyperdynamic-circulation-and-cardiodynamic-states-in-cirrhosis
#12
LETTER
Laura Turco, Guadalupe Garcia-Tsao, Rosario Rossi, Erica Villa, Filippo Schepis
No abstract text is available yet for this article.
June 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29870762/protective-effects-of-heme-oxygenase-1-during-ischemia-r-epefrfsuion-injury-hepatocytes-or-non-parenchymal-cells
#13
LETTER
Kojiro Nakamura, Min Zhang, Shoichi Kageyama, Bibo Ke, Jesus A Araujo, Jerzy W Kupiec-Weglinski
No abstract text is available yet for this article.
June 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29870761/reply-to-influence-of-ablation-technique-on-treatment-failure-for-perivascular-hepatocellular-carcinoma
#14
LETTER
Sunyoung Lee, Tae Wook Kang
No abstract text is available yet for this article.
June 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29870760/from-the-editor-s-desk-august-2018
#15
Richard Moreau, Ramon Bataller, Thomas Berg, Sophie Lotersztajn, Jessica Zucman-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
June 2, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29859853/author-response-is-obesity-a-risk-factor-for-the-development-of-acute-on-chronic-liver-failure-in-patients-with-decompensated-cirrhosis
#16
LETTER
Vinay Sundaram, David S Goldberg, Rajiv Jalan
No abstract text is available yet for this article.
May 31, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29858042/towards-a-definite-mouse-model-of-nafld
#17
EDITORIAL
Rui E Castro, Anna Mae Diehl
No abstract text is available yet for this article.
May 29, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29843905/real-world-data-on-antiviral-treatments-for-hepatitis-c-virus-infections-can-we-define-intention-to-treat-or-per-protocol-analyses
#18
LETTER
Rohit P Ojha, Ewout W Steyerberg
No abstract text is available yet for this article.
May 26, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29807763/influence-of-ablation-technique-on-treatment-failure-for-perivascular-hepatocellular-carcinoma
#19
LETTER
Kayvan Mohkam, Agnès Rode, Jean-Yves Mabrut
No abstract text is available yet for this article.
May 25, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29803899/intestinal-hif-1%C3%AE-deletion-exacerbates-alcoholic-liver-disease-through-inducing-intestinal-dysbiosis-and-barrier-dysfunction
#20
Tuo Shao, Cuiqing Zhao, Fengyuan Li, Zelin Gu, Limimg Liu, Lihua Zhang, Yuhua Wang, Liqing He, Yunhuan Liu, Qi Liu, Yiping Chen, Hridgandh Donde, Rui Wang, Venkatakrishna R Jala, Shirish Barve, Shao-Yu Chen, Xiang Zhang, Yongping Chen, Craig J McClain, Wenke Feng
OBJECTIVES: Alcoholic liver disease (ALD) is characterized by gut dysbiosis and increased gut permeability. Hypoxia Induced Factor 1α (HIF-1α) has been implicated in transcriptional regulation of intestinal barrier integrity and inflammation. We aimed to test the hypothesis that HIF-1α plays a critical role in gut microbiota homeostasis and the maintenance of intestinal barrier integrity in a mouse model of ALD. METHODS: Wide type (WT) and intestinal epithelial-specific HIF-1α knockout mice (IEhif-1α-/- ) were pair-fed modified Lieber-DeCarli liquid diet containing 5% (w/v) alcohol or isocaloric maltose dextrin for 24 days...
May 24, 2018: Journal of Hepatology
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