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Journal of Hepatology

Gennaro D'Amico, Ramon Bataller
No abstract text is available yet for this article.
October 11, 2018: Journal of Hepatology
Anna Carter, Simon Mark Brackley, Jiali Gao, Jake Peter Mann
BACKGROUND & AIMS: Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive condition that may present in a mild form (cholesteryl ester storage disease (CESD)), which mimics non-alcoholic fatty liver disease (NAFLD). It has been suggested that CESD may affect 1 in 40,000 and is under-diagnosed in NAFLD clinics. Therefore, we aimed to estimate the prevalence of LAL-D using analysis of genetic variation in LIPA. METHODS: MEDLINE and EMBASE were systematically searched for previously reported disease variants and prevalence estimates...
October 10, 2018: Journal of Hepatology
Alastair O'Brien, Patrick S Kamath, James Trotter
No abstract text is available yet for this article.
October 9, 2018: Journal of Hepatology
Katharina Brandl, Phillipp Hartmann, Lily J Jih, Donald P Pizzo, Bernd Schnabl
No abstract text is available yet for this article.
October 6, 2018: Journal of Hepatology
Eleonora De Martin, Jean-Marie Michot, Barbara Papouin, Stephane Champiat, Olivier Lambotte, Caroline Robert, Aurelien Marabelle, Catherine Guettier, Didier Samuel
No abstract text is available yet for this article.
October 5, 2018: Journal of Hepatology
Lianne R de Haan, Rowan F van Golen
No abstract text is available yet for this article.
October 4, 2018: Journal of Hepatology
Lucia Parlati, Anais Vallet-Pichard, Rui Batista, Alain Hernvann, Philippe Sogni, Stanislas Pol, Vincent Mallet
No abstract text is available yet for this article.
October 3, 2018: Journal of Hepatology
Saumya Jayakumar, Michael S Middleton, Eric J Lawitz, Parvez S Mantry, Stephen H Caldwell, Hays Arnold, Anna Mae Diehl, Reem Ghalib, Magdy Elkhashab, Manal F Abdelmalek, Kris V Kowdley, C Stephen Djedjos, Ren Xu, Ling Han, G Mani Subramanian, Robert P Myers, Zachary D Goodman, Nezam H Afdhal, Michael R Charlton, Claude B Sirlin, Rohit Loomba
BACKGROUND & AIMS: Noninvasive tools for monitoring treatment response and disease progression in nonalcoholic steatohepatitis (NASH) are needed. Our objective was to evaluate the utility of magnetic resonance (MR)-based hepatic imaging measures for the assessment of liver histology in patients with NASH. METHODS: We analyzed data from NASH patients with stage 2 or 3 fibrosis enrolled in a phase 2 study of selonsertib. Pre- and post-treatment assessments included centrally-read MR elastography (MRE)-estimated liver stiffness, MR imaging-estimated proton density fat fraction (MRI-PDFF), and liver biopsies evaluated according to the NASH Clinical Research Network (CRN) classification and the nonalcoholic fatty liver disease (NAFLD) Activity Score (NAS)...
October 3, 2018: Journal of Hepatology
Mindie H Nguyen, A Burak Ozbay, Iris Liou, Nicole Meyer, Stuart C Gordon, Geoffrey Dusheiko, Joseph K Lim
BACKGROUND/AIM: Chronic hepatitis B (CHB) affects over 2 million people in the United States (US), with little reported on healthcare utilization and cost. We aimed to quantify annual CHB utilization and costs by disease severity and payer type. METHODS: Using Commercial, Medicare, and Medicaid databases from 2004 to 2015 and ICD9 codes, we retrospectively identified CHB adults analyzing all-cause inpatient, outpatient, and pharmaceutical utilization and costs by disease severity...
October 1, 2018: Journal of Hepatology
Yan Chen, Hai-Ning Chen, Kui Wang, Lu Zhang, Zhao Huang, Jiayang Liu, Zhe Zhang, Maochao Luo, Yunlong Lei, Yong Peng, Zong-Guang Zhou, Yuquan Wei, Canhua Huang
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a common cancer worldwide and remains a major clinical challenge. Ketoconazole, a traditional antifungal agent, has attracted considerable attention as a therapeutic option for cancer treatment. However, the involved mechanism of action is still not clearly defined. We aimed to evaluate the effect of ketoconazole on HCC and investigate the underlying mechanisms. METHODS: We examined the antitumor effect of ketoconazole on HCC cells, cell line-derived xenografts, and patient-derived xenograft (PDX) model...
October 1, 2018: Journal of Hepatology
Harvinder Saggi, Dhiman Maitra, An Jiang, Rong Zhang, Pengcheng Wang, Pamela Cornuet, Sucha Singh, Joseph Locker, Xiaochao Ma, Harry Dailey, Marc Abrams, M Bishr Omary, Satdarshan P Monga, Kari Nejak-Bowen
BACKGROUND & AIMS: Porphyrias occur from anomalies of heme biosynthetic enzymes and can lead to cirrhosis and hepatocellular cancer. In mice, these diseases can be modeled by administration of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) containing diet, which causes accumulation of porphyrin intermediates, resulting in hepatobiliary injury. Wnt/β-catenin signaling has been shown to be a modulatable target in models of biliary injury; thus, we investigated its role in DDC-driven injury...
October 1, 2018: Journal of Hepatology
Pamela S Belperio, Troy A Shahoumian, Timothy P Loomis, Larry A Mole, Lisa I Backus
BACKGROUND & AIM: Understanding the real-world effectiveness of all-oral hepatitis C virus (HCV) regimens informs treatment decisions. We evaluated the effectiveness of daclatasvir+sofosbuvir±ribavirin (DCV+SOF±RBV) and velpatasvir/sofosbuvir (VEL/SOF)±RBV in genotype 2 and genotype 3 patients treated in routine practice. METHODS: Observational, intent-to-treat cohort of genotype 2 and genotype 3 patients initiating DCV+SOF±RBV or VEL/SOF±RBV at any Department of Veterans Affairs facility...
September 25, 2018: Journal of Hepatology
Sumeet K Asrani, Harshad Devarbhavi, John Eaton, Patrick S Kamath
Liver disease accounts for approximately 2 million deaths per year worldwide, one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost and account for 1.6% and 2.1% of worldwide burden...
September 25, 2018: Journal of Hepatology
Arianna Mazzotti, Maria Turchese Caletti, Lucia Brodosi, Silvia Di Domizio, Maria Luisa Forchielli, Salvatore Petta, Elisabetta Bugianesi, Giampaolo Bianchi, Giulio Marchesini
BACKGROUND & AIMS: Interventions aimed at lifestyle changes are pivotal for the treatment of non-alcoholic fatty liver disease (NAFLD), and web-based programs might help remove barriers in both patients and therapists. METHODS: In the period 2010-15, 716 consecutive NAFLD cases (mean age, 52; type 2 diabetes, 33%) were treated in our Department with structured programs. The usual protocol included motivational interviewing and a group-based intervention (GBI), chaired by physicians, dietitians and psychologists (five weekly meetings, n = 438)...
September 22, 2018: Journal of Hepatology
Yves Deugnier, Jeff Morcet, Fabrice Lainé, Houda Hamdi-Roze, Anne-Sophie Bollard, Dominique Guyader, Romain Moirand, Edouard Bardou-Jacquet
BACKGROUND: Genetic hemochromatosis is mainly related to the homozygous genotype for the HFE p.Cys282Tyr (C282Y) mutation leading to hepcidin deficiency. Its low penetrance suggests the involvement of cofactors modulating its expression AIM: To describe the evolution of disease presentation and of non-genetic factors liable to impact hepcidin production in the long term. PATIENTS & METHODS: Clinical symptoms, markers of iron load, and risk factors according to the year of diagnosis were recorded over 30 years in a cohort of C282Y homozygotes ≥ 18 years...
September 20, 2018: Journal of Hepatology
Joseph T S Low, Gudrun Rohde, Katherine Pittordou, Bridget Candy, Sarah Davis, Aileen Marshall, Paddy Stone
BACKGROUND: People with cirrhosis have unmet needs, which could benefit from a palliative care approach. Developing effective services needs to be evidence based from those with personal experience. This review aims to explore; patient and family perspectives of perceived needs including communication; health professionals' perspectives on delivery of care and improving palliative care between specialities. METHODS: A literature search conducted in Medline, Embase and CINAHL using key words reporting on the perspectives of patients with liver cirrhosis (18 years and over), family members or health professionals on the provision of care in liver cirrhosis...
September 19, 2018: Journal of Hepatology
Regina Hwang, Peter Liou, Tomoaki Kato
No abstract text is available yet for this article.
September 19, 2018: Journal of Hepatology
Javier Fernández, Faouzi Saliba
No abstract text is available yet for this article.
September 18, 2018: Journal of Hepatology
Yohan Kim, Kyojin Kang, Seung Bum Lee, Daekwan Seo, Sangtae Yoon, Heung Mo Yang, Sung Joo Kim, Kiseok Jang, Yun Kyung Jung, Kyeong Geun Lee, Valentina M Factor, Jaemin Jeong, Dongho Choi
BACKGROUND & AIMS: Currently, much effort is directed towards the development of new cell sources for clinical therapy using cell fate conversion approaches by small molecules. Direct lineage reprogramming to a progenitor state has been reported in terminally differentiated rodent hepatocytes, yet remains a challenge in human hepatocytes. METHODS: Human hepatocytes were isolated from healthy and diseased donor livers and reprogrammed into progenitor cells by two small molecules, A83-01 and CHIR99021 (AC), in the presence of EGF and HGF...
September 18, 2018: Journal of Hepatology
Anthony W H Chan, Jianhong Zhong, Sarah Berhane, Hidenori Toyoda, Alessandro Cucchetti, KeQing Shi, Toshifumi Tada, Charing C N Chong, Bang-De Xiang, Le-Qun Li, Paul B S Lai, Vincenzo Mazzaferro, Marta García-Fiñana, Masatoshi Kudo, Takashi Kumada, Sasan Roayaie, Philip J Johnson
BACKGROUND & AIMS: Resection is the most widely used potentially curative treatment for patients with early hepatocellular carcinoma (HCC). However, recurrence within 2 years occurs in 30-50% of patients, being the major cause of mortality. Herein, we describe 2 models, both based on widely available clinical data, which permit risk of early recurrence to be assessed before and after resection. METHODS: A total of 3,903 patients undergoing surgical resection with curative intent were recruited from 6 different centres...
September 18, 2018: Journal of Hepatology
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