journal
MENU ▼
Read by QxMD icon Read
search

Journal of Hepatology

journal
https://www.readbyqxmd.com/read/28088582/ripk1-protects-hepatocytes-from-kupffer-cells-mediated-tnf-induced-apoptosis-in-mouse-models-of-pamp-induced-hepatitis
#1
Aveline Filliol, Claire Piquet-Pellorce, Céline Raguénès-Nicol, Sarah Dion, Muhammad Farooq, Catherine Lucas-Clerc, Peter Vandenabeele, Mathieu J M Bertrand, Jacques Le Seyec, Michel Samson
BACKGROUND & AIMS: The severity of liver diseases is exacerbated by the death of hepatocytes, which can be induced by the sensing of Pathogen Associated Molecular Patterns (PAMPs) derived from the gut microbiota. The molecular mechanisms regulating these cell death pathways are poorly documented. In this study, we investigated the role of the Receptor Interacting Protein Kinase 1 (RIPK1), a protein known to regulate cell fate decisions, in the death of hepatocytes using two in vivo models of PAMP-induced hepatitis...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28088581/a-stepwise-algorithm-using-a-at-a-glance-first-line-test-for-the-non-invasive-diagnosis-of-advanced-liver-fibrosis-and-cirrhosis
#2
Jérôme Boursier, Victor de Ledinghen, Vincent Leroy, Rodolphe Anty, Sven Francque, Dominique Salmon, Adrien Lannes, Sandrine Bertrais, Frederic Oberti, Isabelle Fouchard-Hubert, Paul Calès
BACKGROUND & AIMS: Chronic liver diseases (CLD) are highly frequent and thus mainly managed by non-hepatologists. Because they lack access to the best non-invasive tests of liver fibrosis, these physicians cannot accurately determine the disease severity and the need for referral to a hepatologist. We aimed to implement an algorithm, comprising a new first-line test usable by all physicians, for the detection of advanced liver fibrosis in all CLD patients. METHODS: Diagnostic study: 3,754 CLD patients with liver biopsy were 2:1 randomized into derivation and validation sets...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28088580/grand-round-anticoagulation-in-chronic-liver-disease
#3
REVIEW
Ameet Dhar, Benjamin H Mullish, Mark R Thursz
In this Grand Round, we first present a case of a man with decompensated liver disease who subsequently developed a fatal pulmonary embolism, having not been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. We go on to discuss the burden of thrombotic disease in those with chronic liver disease, before a more detailed discussion regarding the current evidence, safety data, and clinical dilemmas regarding the use of anticoagulation in patients with chronic liver disease, as well as discussing potential future directions within this field...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28088579/the-microrna-449-family-inhibits-tgf-%C3%AE-mediated-liver-cancer-cell-migration-by-targeting-sox4
#4
Maria Sandbothe, Reena Buurman, Nicole Reich, Luisa Greiwe, Beate Vajen, Engin Gürlevik, Vera Schäffer, Marlies Eilers, Florian Kühnel, Alejandro Vaquero, Thomas Longerich, Stephanie Roessler, Peter Schirmacher, Michael P Manns, Thomas Illig, Brigitte Schlegelberger, Britta Skawran
BACKGROUND & AIMS: Modulation of microRNA expression is considered for treatment of hepatocellular carcinoma (HCC). Therefore, we characterized the epigenetically regulated microRNA-449 family (miR-449a, miR-449b, miR-449c) with regards to its functional effects and target genes in HCC. METHODS: After transfection of miR-449a, miR-449b, and/or miR-449c, tumor-relevant functional effects were analyzed using in vitro assays and a xenograft mouse model. Binding specificities, target genes, and regulated pathways of each microRNA were identified by microarray analyses...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28082149/histone-deacetylase-inhibitor-for-the-treatment-of-hepatocellular-carcinoma-chemoimmunotherapeutic-perspective-and-prospects
#5
LETTER
Kaku Goto, Naoya Kato
No abstract text is available yet for this article.
January 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28082148/vps33b-is-crucial-for-structural-and-functional-hepatocyte-polarity
#6
Joanna Hanley, Dipok Kumar Dhar, Francesca Mazzacuva, Rebeca Fiadeiro, Jemima J Burden, Anne-Marie Lyne, Holly Smith, Anna Straatman-Iwanowska, Blerida Banushi, Alex Virasami, Kevin Mills, Frédéric P Lemaigre, A S Knisely, Steven Howe, Neil Sebire, Simon Waddington, Coen C Paulusma, Peter Clayton, Paul Gissen
BACKGROUND: In the normal liver, hepatocytes form a uniquely polarised cell layer that enables movement of solutes from sinusoidal blood to canalicular bile. Whilst several cholestatic liver diseases with defects of hepatocyte polarity have been identified, the molecular mechanisms of pathogenesis are not well defined. One example is arthrogryposis, renal dysfunction and cholestasis syndrome, which in most patients is caused by VPS33B mutations. VPS33B is a protein involved in membrane trafficking that interacts with RAB11A at recycling endosomes...
January 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28082147/hepatitis-c-true-late-relapse-beyond-48-weeks-of-sustained-virologic-response-after-direct-acting-antiviral-therapy
#7
LETTER
Thomas Klag, Julia Dietz, Christoph R Werner, Julia M Schwarz, Ulrich M Lauer, Robert Beck, Nisar P Malek, Christoph Sarrazin, Christoph P Berg
No abstract text is available yet for this article.
January 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28082146/reply-to-histone-deacetylase-inhibitor-for-the-treatment-of-hepatocellular-carcinoma-chemoimmunotherapeutic-perspective-and-prospects
#8
LETTER
Michael Bitzer, Helmut R Salih
No abstract text is available yet for this article.
January 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28069352/corrigendum-to-signal-transducer-and-activator-of-transcription-3-is-a-major-kinase-independent-target-of-sorafenib-in-hepatocellular-carcinoma
#9
Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Hsiang-Po Huang, Jui-Wen Huang, Pei-Jer Chen, Kuen-Feng Chen
No abstract text is available yet for this article.
January 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28063617/corrigendum-to-lipocalin-2-mediates-non-alcoholic-steatohepatitis-by-promoting-neutrophil-macrophage-crosstalk-via-the-induction-of-cxcr2
#10
Dewei Ye, Kangmin Yang, Shufei Zang, Zhuofeng Lin, Hau-Tak Chau, Yudong Wang, Jialiang Zhang, Junping Shi, Aimin Xu, Shaoqiang Lin, Yu Wang
No abstract text is available yet for this article.
January 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28043875/reply-to-heavy-daily-alcohol-intake-at-the-population-level-predicts-the-weight-of-alcohol-in-cirrhosis-burden-worldwide-methodological-issues-of-confounding-and-prediction-models
#11
LETTER
Monica Cruz-Lemini, Jose Altamirano, Nambi Ndugga, Juan G Abraldes, Ramon Bataller
No abstract text is available yet for this article.
December 30, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28043874/intrahepatic-innate-immune-response-pathways-are-down-regulated-in-untreated-chronic-hepatitis-b
#12
Fanny Lebossé, Barbara Testoni, Judith Fresquet, Floriana Facchetti, Enrico Galmozzi, Maëlenn Fournier, Valérie Hervieu, Pascale Berthillon, Françoise Berby, Isabelle Bordes, David Durantel, Massimo Levrero, Pietro Lampertico, Fabien Zoulim
BACKGROUND AND AIMS: Hepatitis B virus (HBV) persistence and the pathobiology of chronic HBV (CHB) infections result from the interplay between viral replication and host immune responses. Intrahepatic host genes expression and a comprehensive analysis of serum and liver HBV markers were performed in a large cohort of untreated CHB patients. PATIENTS AND METHODS: 105 CHB patients untreated at the time of liver biopsy (34 HBeAg(+) and 71 HBeAg(-)) were analysed for the intrahepatic expression profile of 67 genes belonging to multiple innate immunity pathways...
December 30, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28043873/heavy-daily-alcohol-intake-at-the-population-level-predicts-the-weight-of-alcohol-in-cirrhosis-burden-worldwide-methodological-issues-of-confounding-and-prediction-models
#13
LETTER
Erfan Ayubi, Saeid Safiri, Mohadeseh Sani, Salman Khazaei, Kamyar Mansori
No abstract text is available yet for this article.
December 30, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28040549/increased-peripheral-cd4-regulatory-t-cells-persist-after-successful-direct-acting-antiviral-treatment-of-chronic-hepatitis-c
#14
Bettina Langhans, Hans Dieter Nischalke, Benjamin Krämer, Annekristin Hausen, Leona Dold, Peer van Heteren, Robert Hüneburg, Jacob Nattermann, Christian P Strassburg, Ulrich Spengler
INTRODUCTION: CD4(+) regulatory T cells (Tregs) expand during chronic hepatitis C virus (HCV) infection, inhibit antiviral immunity and promote fibrosis. Directly acting antivirals (DAA) have revolutionized HCV therapy. However, it is unclear if Tregs are normalized after DAA-induced HCV elimination. METHODS: We analyzed Tregs before (=baseline), at end of therapy (EOT), 12 and 24 weeks (SVR12, SVR24) and long-term (51±14 weeks) after EOT in 26 genotype-1-infected patients successfully treated with sofosbuvir (SOF) plus IFN/ribavirin (n=12) and IFN-free DAA regimens (SOF plus daclatasvir or simeprevir; n=14)...
December 28, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28040548/type-i-interferon-signaling-in-systemic-immune-cells-from-patients-with-alcoholic-cirrhosis-and-its-association-with-outcome
#15
Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu, Mikhael Giabicani, Marc de Chambrun, JingHong Wan, Charlotte Minsart, Thierry Gustot, Alain Couvineau, Rakhi Maiwall, Margarita Hurtado-Nedelec, Nathalie Pilard, Didier Lebrec, Dominique Valla, François Durand, Pierre de la Grange, Renato C Monteiro, Catherine Paugam-Burtz, Sophie Lotersztajn, Richard Moreau
BACKGROUND & AIMS: In immune cells, constitutively and acutely produced type I interferons (IFNs) engage autocrine/paracrine signaling pathways to induce IFN-stimulated genes (ISGs). Enhanced activity of IFN signaling pathways can cause excessive inflammation and tissue damage. We aimed to investigate the poorly known ISG expression in systemic immune cells from patients with decompensated alcoholic cirrhosis and its association with outcome. METHODS: Peripheral blood mononuclear cells (PBMCs) from patients and heathy subjects were stimulated or not with lipopolysaccharide (LPS, an IFN inducer) or increasing concentrations of IFN-β...
December 28, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28039099/individual-patient-data-meta-analysis-of-controlled-attenuation-parameter-cap-technology-for-assessing-steatosis
#16
Thomas Karlas, David Petroff, Magali Sasso, Jian-Gao Fan, Yu-Qiang Mi, Victor de Lédinghen, Manoj Kumar, Monica Lupsor-Platon, Kwang-Hyub Han, Ana C Cardoso, Giovanna Ferraioli, Wah-Kheong Chan, Vincent Wai-Sun Wong, Robert P Myers, Kazuaki Chayama, Mireen Friedrich-Rust, Michel Beaugrand, Feng Shen, Jean-Baptiste Hiriart, Shiv K Sarin, Radu Badea, Kyu Sik Jung, Patrick Marcellin, Carlo Filice, Sanjiv Mahadeva, Grace Lai-Hung Wong, Pam Crotty, Keiichi Masaki, Joerg Bojunga, Pierre Bedossa, Volker Keim, Johannes Wiegand
BACKGROUND: The prevalence of fatty liver underscores the need for non-invasive characterization of steatosis, such as the ultrasound-based controlled attenuation parameter (CAP). Despite good diagnostic accuracy, clinical use of CAP is limited due to uncertainty regarding optimal cut-offs and the influence of covariates. We therefore conducted an individual patient data meta-analysis. METHODS: A review of the literature identified studies containing histology controlled CAP data (M probe, vibration controlled transient elastography with Fibroscan) for grading of steatosis (S0-S3)...
December 27, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28039098/efficacy-and-tolerability-of-interferon-free-antiviral-therapy-in-kidney-transplant-recipients-with-chronic-hepatitis-c
#17
Inmaculada Fernández, Raquel Muñoz-Gómez, Juan M Pascasio, Carme Baliellas, Natalia Polanco, Nuria Esforzado, Ana Arias, Martín Prieto, Lluis Castells, Valentín Cuervas-Mons, Olga Hernández, Javier Crespo, José L Calleja, Xavier Forns, María-Carlota Londoño
BACKGROUND AND AIMS: The development of direct-acting antivirals (DAAs) is a major step forward in the treatment of hepatitis C (HCV). The aims of the study were to evaluate the efficacy and tolerability of DAAs in kidney transplant (KT) recipients. METHODS: Hepa-C is a Spanish registry of patients treated with DAAs in which clinical, virological and analytical data were prospectively included. RESULTS: We report on the data from 103 KT recipients who received DAAs...
December 27, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28027971/host-conditioning-and-rejection-monitoring-in-hepatocyte-transplantation-in-humans
#18
Kyle A Soltys, Kentaro Setoyama, Edgar N Tafaleng, Alejandro Soto Gutiérrez, Jason Fong, Ken Fukumitsu, Taichiro Nishikawa, Masaki Nagaya, Rachel Sada, Kimberly Haberman, Roberto Gramignoli, Kenneth Dorko, Veysel Tahan, Alexandra Dreyzin, Kevin Baskin, John J Crowley, Mubina A Quader, Melvin Deutsch, Chethan Ashokkumar, Benjamin L Shneider, Robert H Squires, Sarangarajan Ranganathan, Miguel Reyes-Mugica, Steven F Dobrowolski, George Mazariegos, Rajavel Elango, Donna B Stolz, Stephen C Strom, Gerard Vockley, Jayanta Roy-Chowdhury, Marilia Cascalho, Chandan Guha, Rakesh Sindhi, Jeffrey L Platt, Ira J Fox
BACKGROUND: Hepatocyte transplantation partially corrects genetic disorders and has been associated anecdotally with reversal of acute liver failure. Monitoring for graft function and rejection has been difficult, and has contributed to limited graft survival. METHODS: Preparative hepatic irradiation was examined in non-human primates as a strategy to improve engraftment of donor hepatocytes, and was then applied in human subjects. T-cell immune monitoring was also examined in human subjects to assess adequacy of immunosuppression...
December 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28027970/hbv-inhibits-lps-induced-nlrp3-inflammasome-activation-and-il-1%C3%AE-production-via-suppressing-nf-%C3%AE%C2%BAb-pathway-and-ros-production
#19
Xin Yu, Peixiang Lan, Xuben Hou, Qiuju Han, Nan Lu, Tao Li, Chenwei Jiao, Jian Zhang, Cai Zhang, Zhigang Tian
BACKGROUND & AIMS: Hepatitis B virus (HBV) developed multifaceted strategies to evade the surveillance of immune responses, while the precise mechanisms involved remain unclear. The NLRP3 inflammasome plays crucial roles in antiviral host defense and its downstream factor IL-1β has been shown to inhibit HBV infection in vivo. The study aims to assess whether HBV can affect the NLRP3 inflammasome signaling pathways and shed light on the underlying mechanisms HBV utilizes to evade host innate immune response...
December 24, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28025060/liver-sinusoidal-endothelial-cell-cross-priming-is-supported-by-cd4-t-cell-derived-il-2
#20
Michaela Wittlich, Michael Dudek, Jan P Böttcher, Oliver Schanz, Silke Hegenbarth, Tobias Bopp, Edgar Schmitt, Christian Kurts, Christoph Garbers, Stefan Rose John, Percy A Knolle, Dirk Wohlleber
BACKGROUND AND AIMS: Liver sinusoidal endothelial cells (LSECs) are prominent liver-resident antigen (cross-)presenting cells. LSEC cross-priming of naïve CD8 T cells does not require CD4 T cell help in contrast to priming by dendritic cells (DC) but leads to formation of memory T cells that is preceded by transient GzmB expression. Here we provide evidence for a so far unrecognized CD4 T helper cell-function in LSEC-induced CD8 T cell-activation. METHODS: Naïve CD8 T cells and differentiated T helper 1 (Th1) cells were stimulated by antigen-presenting LSEC and GzmB expression in CD8 T cells was determined by flow cytometry...
December 23, 2016: Journal of Hepatology
journal
journal
20153
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"