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Journal of Hepatology

Massimiliano Cadamuro, Simone Brivio, Joachim Mertens, Marta Vismara, Anja Moncsek, Chiara Milani, Christian Fingas, Maria Cristina Malerba, Giorgia Nardo, Luigi Dall'Olmo, Eleonora Milani, Valeria Mariotti, Tommaso Stecca, Marco Massani, Carlo Spirli, Romina Fiorotto, Stefano Indraccolo, Mario Strazzabosco, Luca Fabris
BACKGROUND: /Aims. In cholangiocarcinoma, early metastatic spread via lymphatic vessels often precludes curative therapies. Cholangiocarcinoma invasiveness is fostered by an extensive stromal reaction, enriched in cancer-associated fibroblasts (CAF) and lymphatic endothelial cells (LEC). Cholangiocarcinoma cells recruit and activate CAF by secreting PDGF-D. Here we investigated the role of PDGF-D and liver myofibroblasts in promoting lymphangiogenesis in cholangiocarcinoma. METHODS: Human cholangiocarcinoma specimens were immunostained for podoplanin (LEC marker), α-SMA (CAF), VEGF-A, VEGF-C, and their cognate receptors (VEGFR2, VEGFR3)...
December 13, 2018: Journal of Hepatology
Solène Denolly, Christelle Granier, Nelly Fontaine, Bruno Pozzetto, Thomas Bourlet, Maryse Guérin, François-Loïc Cosset
BACKGROUND & AIMS: Hepatitis C virus (HCV) particles detected in sera from infected patients display heterogeneous forms of low-buoyant densities (<1.08), underscoring their lipidation via association with apoB-containing lipoproteins, which was proposed to occur during assembly or secretion from infected hepatocytes. However, the mechanisms inducing this association remain poorly-defined and, intriguingly, most HCVcc particles secreted from cultured cells exhibit higher density (>1...
December 13, 2018: Journal of Hepatology
Sunyoung Lee, Myeong-Jin Kim, Sohee Kim, Dongil Choi, Kee-Taek Jang, Young Nyun Park
BACKGROUND & AIMS: Imaging characteristics for discriminating malignant potential of intraductal papillary neoplasm of the bile duct (IPNB) still remain unclear. This study aimed to define the magnetic resonance (MR) imaging findings that help to differentiate IPNB with an associated invasive carcinoma from IPNB with intraepithelial neoplasia and to investigate their significance with respect to long-term outcomes in patients with surgically resected IPNB. METHODS: This retrospective study included 120 patients with surgically resected IPNB who underwent preoperative MR imaging with MR cholangiography before surgery from January 2008 and December 2017 in two tertiary referral centers...
December 13, 2018: Journal of Hepatology
Wen-Tao Yan, Bing Quan, Hao Xing, Meng-Chao Wu, Tian Yang
No abstract text is available yet for this article.
December 12, 2018: Journal of Hepatology
Upkar S Gill, Lucy Golden-Mason
No abstract text is available yet for this article.
December 11, 2018: Journal of Hepatology
Zhenqiu Liu, Yanfeng Jiang, Huangbo Yuan, Qiwen Fang, Ning Cai, Chen Suo, Li Jin, Tiejun Zhang, Xingdong Chen
BACKGROUND & AIMS: Liver cancer is a common malignant neoplasm worldwide. The etiologies for liver cancer are diverse and the incidence trends of liver cancer caused by specific etiologies are rarely studied. METHODS: We collected detailed information on liver cancer etiology between 1990-2016, derived from the global burden of disease (GBD) in 2016. Estimated annual percentage changes (EAPC) in liver cancer age standardized incidence rate (ASR), by sex, region, and etiology, were calculated to quantify the temporal trends in liver cancer ASR...
December 10, 2018: Journal of Hepatology
Mary E Rinella, James F Trotter, Manal F Abdelmalek, Angelo H Paredes, Margery A Connelly, Mark J Jaros, Lei Ling, Stephen J Rossi, Alex M DePaoli, Stephen A Harrison
BACKGROUND: NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with nonalcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes the rate-limiting enzyme in the conversion of cholesterol to bile acids. Here, we investigate whether administration of a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor can manage the cholesterol increase seen in NASH patients treated with NGM282...
December 7, 2018: Journal of Hepatology
Testoni Barbara, Lebossé Fanny, Scholtes Caroline, Berby Françoise, Miaglia Clothilde, Subic Miroslava, Loglio Alessandro, Facchetti Floriana, Lampertico Pietro, Levrero Massimo, Zoulim Fabien
BACKGROUND AND AIMS: Serum Hepatitis B core-related antigen (HBcrAg) has been proposed to reflect the intrahepatic cccDNA levels, but a comprehensive investigation of its correlation with serum and intrahepatic viral markers and liver histology in a large number of patients is still lacking. METHODS: HBcrAg was measured by chemiluminescent enzyme immunoassay (Fujirebio Lumipulse® G HBcrAg) in 130 [36 HBeAg(+) and 94 HBeAg(-)] biopsy proven, untreated, CHB patients...
December 6, 2018: Journal of Hepatology
Joong-Won Park, Yoon Jun Kim, Do Young Kim, Si-Hyun Bae, Seung Woon Paik, Youn-Jae Lee, Hwi Young Kim, Han Chu Lee, Sang Young Han, Jae Youn Cheong, Oh Sang Kwon, Jong Eun Yeon, Bo Hyun Kim, Jaeseok Hwang
BACKGROUND/AIMS: To compare clinical outcomes of sorafenib combined with concurrent conventional transarterial chemoembolization (cTACE) (SOR+T) with those of sorafenib alone in patients with advanced hepatocellular carcinoma (HCC) in an investigator-initiated, multicenter, randomized, phase III trial. METHODS: After randomization, all eligible patients received sorafenib with (Arm C, n=170) or without (Arm S, n=169) cTACE within 3 days and cTACE within 7-21 days, with repeated cTACE on demand (Arm C)...
December 5, 2018: Journal of Hepatology
Yannan Fan, Sehrish K Bazai, Fabrice Daian, Maria Arechederra, Sylvie Richelme, Nuri A Temiz, Annie Yim, Bianca H Habermann, Rosanna Dono, David A Largaespada, Flavio Maina
BACKGROUND & AIMS: The variety of alterations found in hepatocellular carcinoma (HCC) challenges the identification of functionally relevant genes and their combinatorial actions in tumorigenesis. Deregulation of Receptor Tyrosine Kinases (RTKs) is frequent in HCC, yet little is known about the molecular events that cooperate with RTKs and whether these cooperative events play an active role at the root of liver tumorigenesis. METHODS: A forward genetic screen was performed using Sleeping Beauty transposon insertional mutagenesis to accelerate liver tumour formation in a genetic context in which subtly increased MET RTK levels predispose towards tumorigenesis...
December 5, 2018: Journal of Hepatology
Anne Boerekamps, Thomas Vanwolleghem, Marc van der Valk, Guido E van den Berk, Marjo van Kasteren, Dirk Posthouwer, Anthonius S M Dofferhoff, Bart van Hoek, Dewkoemar Ramsoekh, Jelle Koopsen, Janke Schinkel, Eric Florence, Joop E Arends, Bart J Rijnders
No abstract text is available yet for this article.
December 5, 2018: Journal of Hepatology
Eleonora De Martin, Jean-Marie Michot, Barbara Papouin, Stephane Champiat, Olivier Lambotte, Caroline Robert, Aurelien Marabelle, Catherine Guettier, Didier Samuel
No abstract text is available yet for this article.
December 4, 2018: Journal of Hepatology
Philippe Ichai, Astrid Laurent-Bellue, Christophe Camus, David Moreau, Mathieu Boutonnet, Faouzi Saliba, Jean Marie Peron, Carole Ichai, Emilie Gregoire, Luc Aigle, Julien Cousty, Alice Quinart, Bertrand Pons, Marc Boudon, Stephane André, Audrey Coilly, Teresa Antonini, Catherine Guettier, Didier Samuel
Severe acute liver injury (sALI) is a grave complication of exertional heatstroke (EH). Liver transplantation (LT) may be a therapeutic option, but the criteria for, and timing of transplantation have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context. PATIENTS AND METHODS: This was a multicentre, retrospective study of patients admitted with a diagnosis of EH-related sALI with a prothrombin time (PT) of less than 50%...
December 3, 2018: Journal of Hepatology
Mar Riveiro-Barciela, Eva Muñoz-Couselo, Jesús Fernandez-Sojo, Nely Diaz-Mejia, Rafael Parra-López, María Buti
No abstract text is available yet for this article.
November 28, 2018: Journal of Hepatology
Line Modin, Adam Arshad, Bryony Wilkes, Jennifer Benselin, Carla Lloyd, William L Irving, Deirdre A Kelly
BACKGROUND: Chronic hepatitis C virus (HCV) infection is a global health burden. Although HCV infection rarely contributes to morbidity during childhood, the majority of HCV infected children develop chronic HCV with a lifetime risk of liver disease. Little is known about the development of long-term liver disease and treatment effect in patients infected with HCV in childhood. METHOD: Retrospective review of patients infected with HCV in childhood enrolled in HCV Research UK...
November 26, 2018: Journal of Hepatology
Minou van Seyen, Elise J Smolders, Peter van Wijngaarden, Joost P H Drenth, Marjan Wouthuyzen-Bakker, Robert J de Knegt, Pieter Honkoop, Omar El-Sherif, Angela Colbers, David J Back, David M Burger
No abstract text is available yet for this article.
November 22, 2018: Journal of Hepatology
Yongzhen Liu, Wanjia Zeng, Jingyuan Xi, Hui Liu, Hao Liao, Guangxin Yu, Xiangmei Chen, Fengmin Lu
No abstract text is available yet for this article.
November 22, 2018: Journal of Hepatology
Roberta D'Ambrosio, Luisa Pasulo, Massimo Puoti, Maria Vinci, Monica Schiavini, Sergio Lazzaroni, Alessandro Soria, Federico Gatti, Barbara Menzaghi, Alessio Aghemo, Francesca Capelli, Maria Grazia Rumi, Lorenzo Morini, Alessia Giorgini, Marie Graciella Pigozzi, Angelo Rossini, Franco Maggiolo, Angelo Pan, Massimo Memoli, Ombretta Spinelli, Paolo Del Poggio, Valeria Saladino, Angiola Spinetti, Anna De Bona, Andrea Capretti, Caterina Uberti-Foppa, Paolo Bonfanti, Natalia Terreni, Fernanda Menozzi, Alberto Eraldo Colombo, Omar Giglio, Riccardo Centenaro, Marta Borghi, Chiara Baiguera, Viviana Picciotto, Simona Landonio, Andrea Gori, Carlo Magnani, Franco Noventa, Stefania Paolucci, Pietro Lampertico, Stefano Fagiuoli
BACKGROUND AND AIMS: Efficacy and safety of Glecaprevir/Pibrentasvir (G/P) among hepatitis C virus (HCV) infected patients have been only investigated in clinical trials, and no real-life data are available yet. The aim of our study was to investigate effectiveness and safety of G/P in an Italian real-life setting. METHODS: All HCV patients consecutively starting G/P between October 2017 and January 2018 within the NAVIGATORE-Lombardia Network were analyzed. G/P was administered according to drug label (8, 12 or 16 weeks)...
November 22, 2018: Journal of Hepatology
Andrea Rasche, Anna-Lena Sander, Victor Max Corman, Jan Felix Drexler
Hepatitis viruses are major threats to human health. During the last decade, highly diverse viruses related to human hepatitis viruses were found in animals other than primates. Here, we compare the unique biological properties and infection patterns of human hepatitis viruses and their animal homologues. We describe both surprising conservation and striking differences of infection patterns between human hepatitis viruses and their animal homologues, including transmission routes, liver tropism, oncogenesis, chronicity and envelopment...
November 22, 2018: Journal of Hepatology
Rui Costa, Daniel Todt, Francisco Zapatero-Belinchón, Christian Schenk, Olympia E Anastasiou, Andreas Walker, Barbara Hertel, Lejla Timmer, Denisa Bojkova, Maren Ruckert, Christoph Sarrazin, Jörg Timm, Volker Lohmann, Michael P Manns, Eike Steinman, Thomas von Hahn, Sandra Ciesek
BACKGROUND & AIMS: Since the discovery of HCV, efficient viral replication of clinical isolates in cell culture was a challenge. This status quo changed with SEC14L2 mediated viral replication of clinical isolates in cell culture. Given the role of SEC14L2 in HCV replication, we aimed to study a large number of HCV positive sera carrying genotypes 1-4, to identify viral factors associated with efficient replication in cell culture. Additionally, we investigated whether 13 single nucleotide polymorphisms (SNPs) of SEC14L2 have an impact on RNA replication of natural occurring HCV isolates...
November 22, 2018: Journal of Hepatology
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