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Journal of Hepatology

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https://www.readbyqxmd.com/read/30104027/a-changing-landscape-of-liver-transplantation-king-hcv-is-dethroned-ald-and-nafld-take-over
#1
EDITORIAL
Norah A Terrault, Georges-Philippe Pageaux
No abstract text is available yet for this article.
August 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30104026/corrigendum-to-prognostic-factors-and-predictors-of-sorafenib-benefit-in-patients-with-hepatocellular-carcinoma-analysis-of-two-phase-iii-studies-j-hepatol-67-2017-999-1008
#2
Jordi Bruix, Ann-Lii Cheng, Gerold Meinhardt, Keiko Nakajima, Yoriko De Sanctis, Josep Llovet
No abstract text is available yet for this article.
August 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30104025/the-multi-dimensional-role-of-intestinal-hifs-in-liver-pathobiology
#3
EDITORIAL
Xinshou Ouyang, Wajahat Z Mehal
No abstract text is available yet for this article.
August 10, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30098373/no-impact-of-resistance-associated-substitutions-on-the-efficacy-of-sofosbuvir-velpatasvir-and-voxilaprevir-for-12-weeks-in-hcv-daa-experienced-patients
#4
Christoph Sarrazin, Curtis L Cooper, Michael P Manns, K Rajender Reddy, Kris V Kowdley, Stuart K Roberts, Hadas Dvory-Sobol, Evguenia Svarovskia, Ross Martin, Gregory Camus, Brian P Doehle, Luisa M Stamm, Robert H Hyland, Diana M Brainard, Hongmei Mo, Stuart C Gordon, Marc Bourliere, Stefan Zeuzem, Steven L Flamm
BACKGROUND & AIMS: The pangenotypic direct-acting antiviral agents of sofosbuvir (SOF), velpatasvir (VEL), and voxilaprevir (VOX), inhibit distinct HCV targets: the NS5B polymerase, the NS5A protein, and NS3/4A protease, respectively. In Phase 3 studies, fixed dose combination of SOF/VEL/VOX administered for 12 weeks demonstrated a 96% SVR12 rate in NS5A inhibitor-experienced patients, and a 98% SVR12 rate in DAA-experienced patients who had not previously received an NS5A inhibitor...
August 8, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30097328/corrigendum-to-recipient-characteristics-and-morbidity-and-mortality-after-liver-transplantation-j-hepatol-69-2018-43-50
#5
Sumeet K Asrani, Giovanna Saracino, Jacqueline G O'Leary, Stevan Gonzalez, Peter T Kim, Greg J McKenna, Goran Klintmalm, James Trotter
No abstract text is available yet for this article.
August 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30097327/reply-to-mortality-due-to-immunotherapy-related-hepatitis
#6
LETTER
Eleonora De Martin, Jean-Marie Michot, Barbara Papouin, Stephane Champiat, Olivier Lambotte, Caroline Robert, Aurelien Marabelle, Catherine Guettier, Didier Samuel
No abstract text is available yet for this article.
August 7, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30093162/mortality-due-to-immunotherapy-related-hepatitis
#7
LETTER
Prachi Bhave, Andrew Buckle, Shahneen Sandhu, Siddharth Sood
No abstract text is available yet for this article.
August 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30093161/clinical-use-of-dendritic-cell-derived-exosomes-for-hepatocellular-carcinoma-immunotherapy-how-far-we-are
#8
LETTER
Xinyu Yang, Jiale Chen, Ning Wang, Zhui Liu, Yuan Li
No abstract text is available yet for this article.
August 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30093160/immunotolerant-children-with-chronic-hepatitis-b-to-treat-or-not-the-dilemma-continues
#9
LETTER
Bikrant Bihari Lal, Vikrant Sood, Rajeev Khanna, Seema Alam
No abstract text is available yet for this article.
August 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30092234/estimate-of-hepatocellular-carcinoma-s-incidence-in-patients-with-alcoholic-cirrhosis
#10
Nathalie Ganne-Carrié, Cendrine Chaffaut, Valérie Bourcier, Isabelle Archambeaud, Jean-Marc Perarnau, Frédéric Oberti, Dominique Roulot, Christophe Moreno, Alexandre Louvet, Thông Dao, Romain Moirand, Odile Goria, Eric Nguyen-Khac, Nicolas Carbonell, Térésa Antonini, Stanislas Pol, Victor de Ledinghen, Violaine Ozenne, Jean Henrion, Jean-Marie Péron, Albert Tran, Gabriel Perlemuter, Xavier Amiot, Jean-Pierre Zarski, Michel Beaugrand, Sylvie Chevret
BACKGROUND AND AIMS: The CIRRAL cohort aimed to assess the burden of complications in patients with alcoholic cirrhosis, particularly the occurrence of hepatocellular carcinoma (HCC). PATIENTS: With biopsy-proven compensated alcoholic cirrhosis were included then prospectively followed. The main end point was the incidence of HCC. Secondary outcomes were incidence of hepatic focal lesions, overall survival (OS), liver-related mortality and event-free survival (EFS)...
August 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30089577/impact-of-direct-acting-antiviral-therapy-on-the-need-for-liver-transplantation-related-to-hepatitis-c-in-germany
#11
LETTER
Kerstin Herzer, Guido Gerken, Daniela Kroy, Frank Tacke, Julius Plewe, Dennis Eurich, Ulrich Spengler, Christian P Strassburg, Martin-Walter Welker, Sven Pischke, Martina Sterneck, Arianeb Mehrabi, Karl Heinz Weiss, Adam Herber, Thomas Berg, Tim Zimmermann, Peter R Galle, Hauke Heinzow, Hartmut Schmidt, Antoaneta Markova, Yvonne Serfert, Michael P Manns, Stefan Zeuzem, Heiner Wedemeyer
No abstract text is available yet for this article.
August 6, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30086997/reply-to-immunotolerant-children-with-chronic-hepatitis-b-to-treat-or-not-the-dilemma-continues
#12
LETTER
Shishu Zhu, Pan Zhao
No abstract text is available yet for this article.
August 4, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30082074/corrigendum-to-a-simple-diet-and-chemical-induced-murine-nash-model-with-rapid-progression-of-steatohepatitis-fibrosis-and-liver-cancer-j-hepatol-69-2018-385-395
#13
Takuma Tsuchida, Youngmin A Lee, Naoto Fujiwara, Maria Ybanez, Brittany Allen, Sebastiao Martins, M Isabel Fiel, Nicolas Goossens, Hsin-I Chou, Yujin Hoshida, Scott L Friedman
No abstract text is available yet for this article.
August 3, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30075230/modified-page-b-score-predicts-the-risk-of-hepatocellular-carcinoma-in-asians-with-chronic-hepatitis-b-on-antiviral-therapy
#14
Ji Hyun Kim, Young Don Kim, Minjong Lee, Baek Gyu Jun, Tae Suk Kim, Ki Tae Suk, Seonghee Kang, Moon Young Kim, Gab Jin Cheon, Dong Joon Kim, Soon Koo Baik, Dae Hee Choi
BACKGROUND & AIMS: Recently, PAGE-B score and Toronto HCC risk index (THRI) have been developed to predict the risk of hepatocellular carcinoma (HCC) in Caucasian patients with chronic hepatitis B (CHB). We aimed to validate PAGE-B scores and THRI in Asian patients with CHB and suggested modified PAGE-B scores to potentiate the predictive performance. METHODS: From 2007 to 2017, we examined 3,001 Asian patients with CHB receiving entecavir/tenofovir therapy...
July 31, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30075229/statins-old-drugs-as-new-therapy-for-liver-diseases
#15
REVIEW
Elisa Pose, Jonel Trebicka, Rajeshwar P Mookerjee, Paolo Angeli, Pere Ginès
In addition to their effects in lowering cholesterol levels, statins have pleiotropic effects, particularly anti-inflammatory, antiangiogenic, and antifibrotic, that may be beneficial in some chronic inflammatory conditions. The effects of statins as potential treatment in chronic liver diseases have not been investigated until very recently due to concerns related to their safety in patients with liver impairment. A number of experimental studies in animal models of liver diseases have shown that statins decrease hepatic inflammation, fibrogenesis and portal pressure...
July 31, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30071241/liver-transplantation-in-patients-with-multiple-organ-failures-feasibility-and-outcomes
#16
Paul J Thuluvath, Avesh J Thuluvath, Steve Hanish, Yulia Savva
BACKGROUND AND AIMS: Multiple organ failures (OF) are common in patients with cirrhosis, but the independent effect of number or type of OF on liver transplant (LT) outcomes is not well defined. METHOD: UNOS data were analyzed from 2002 to 2016 of all adults listed for LT who received LT within 30 days after listing. We estimated post-LT survival stratified by number and type of pre-transplant OF before and after adjusting for confounding variables. RESULTS: During the study period, 4,714 (4...
July 30, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30049546/individualized-prediction-of-hepatocellular-carcinoma-occurrence-in-a-large-cohort-of-patients-with-cirrhosis
#17
LETTER
Astrid Marot, Jean Henrion, Jean-François Knebel, Pierre Deltenre
No abstract text is available yet for this article.
July 23, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30049545/hiv-positive-to-hiv-positive-liver-transplantation-to-be-continued
#18
LETTER
Andrea Lauterio, Maria Cristina Moioli, Stefano Di Sandro, Giovanna Travi, Riccardo De Carlis, Marco Merli, Fabio Ferla, Massimo Puoti, Luciano De Carlis
No abstract text is available yet for this article.
July 23, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30049544/viral-hepatitis-e-is-for-equitable-elimination
#19
EDITORIAL
Jeffrey V Lazarus, Juan M Pericàs, Massimo Colombo, Michael Ninburg, Stefan Wiktor, Mark Thursz
No abstract text is available yet for this article.
July 20, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/30031887/chimeric-liver-transplantation-reveals-interspecific-graft-remodelling
#20
Graziano Oldani, Andrea Peloso, Sandrine Vijgen, Elizabeth M Wilson, Florence Slits, Quentin Gex, Philippe Morel, Vaihere Delaune, Lorenzo A Orci, Tomoyuki Yamaguchi, Toshihiro Kobayashi, Laura Rubbia-Brandt, Hiromitsu Nakauchi, Stéphanie Lacotte, Christian Toso
BACKGROUND & AIMS: Chimeric animals carrying human tissue have the potential to solve the lack of transplantable organs. However, currently available chimeric organs retain a high level of xenogeneic cells, and the transplantation of impure organs needs to be tested. METHODS: We created chimeric livers by injecting Lewis rat hepatocytes into C57Bl/6 Fah-/- Rag2-/- Il2rg-/- mice, and further transplanted them into newly-weaned Lewis rats (45±3g) with or without sub-optimal immunosuppression (tacrolimus 0...
July 19, 2018: Journal of Hepatology
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