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Journal of Heart and Lung Transplantation

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https://www.readbyqxmd.com/read/27865732/prevention-of-heartmate-ii-pump-thrombosis-through-clinical-management-the-prevent-multi-center-study
#1
Simon Maltais, Ahmet Kilic, Sriram Nathan, Mary Keebler, Sitaramesh Emani, John Ransom, Jason N Katz, Brett Sheridan, Andreas Brieke, Gregory Egnaczyk, John W Entwistle, Robert Adamson, John Stulak, Nir Uriel, John B O'Connell, David J Farrar, Kartik S Sundareswaran, Igor Gregoric
BACKGROUND: Recommended structured clinical practices including implant technique, anti-coagulation strategy, and pump speed management (PREVENT [PREVENtion of HeartMate II Pump Thrombosis Through Clinical Management] recommendations) were developed to address risk of early (<3 months) pump thrombosis (PT) risk with HeartMate II (HMII; St. Jude Medical, Inc. [Thoratec Corporation], Pleasanton, CA). We prospectively assessed the HMII PT rate in the current era when participating centers adhered to the PREVENT recommendations...
November 16, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27914896/optimal-ex-vivo-lung-perfusion-techniques-with-oxygenated-perfusate
#2
Kentaro Noda, Shinya Tane, Seok Jin Haam, Awori J Hayanga, Jonathan D'Cunha, James D Luketich, Norihisa Shigemura
BACKGROUND: Accumulating evidence supports an increasing role of ex vivo lung perfusion (EVLP) in clinical lung transplantation. However, EVLP has adverse effects on the quality of lung grafts, which have rarely been discussed. Careful optimization of current EVLP protocols might improve outcomes. This study examined effects of different levels of oxygenation of the perfusate circulated through the lungs during EVLP and the impact on post-transplant functional outcomes. METHODS: We compared results of 4 different oxygenation levels in the perfusate during EVLP: 6% oxygen (O2), 40% O2, 60% O2, and 100% O2...
October 29, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27889369/alemtuzumab-and-de-novo-pulmonary-arterial-hypertension-a-potential-association
#3
LETTER
Laura Beaumier, Sébastien Chanoine, Boubou Camara, Christophe Pison, Pierrick Bedouch
No abstract text is available yet for this article.
October 29, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27866927/mesenchymal-stem-cells-transplantation-during-ex-vivo-lung-perfusion
#4
LETTER
Mohamed S A Mohamed
No abstract text is available yet for this article.
October 24, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27914897/jc-virus-encephalopathy-in-a-lung-transplant-recipient-novel-presentation-of-an-old-virus
#5
LETTER
Yasir Hamad, Fernanda P Silveira, Maria M Crespo
No abstract text is available yet for this article.
October 21, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27914895/subclinical-venous-access-infection-and-clinical-worsening-in-pulmonary-arterial-hypertension
#6
LETTER
Chebib Nader, Mornex Jean-François, Cottin Vincent
No abstract text is available yet for this article.
October 21, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27876413/association-between-plasma-torque-teno-virus-level-and-chronic-lung-allograft-dysfunction-after-lung-transplantation
#7
LETTER
Irene Görzer, Peter Jaksch, Robert Strassl, Walter Klepetko, Elisabeth Puchhammer-Stöckl
No abstract text is available yet for this article.
October 21, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27866928/improved-waitlist-and-transplant-outcomes-for-pediatric-lung-transplantation-after-implementation-of-the-lung-allocation-score
#8
Timothy S Lancaster, Jacob R Miller, Deirdre J Epstein, Nicholas C DuPont, Stuart C Sweet, Pirooz Eghtesady
BACKGROUND: Although the lung allocation score (LAS) has not been considered valid for lung allocation to children, several additional policy changes for pediatric lung allocation have been adopted since its implementation. We compared changes in waitlist and transplant outcomes for pediatric and adult lung transplant candidates since LAS implementation. METHODS: The United Network for Organ Sharing database was reviewed for all lung transplant listings during the period 1995 to June 2014...
October 17, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27866926/evaluation-of-humoral-immunity-profiles-to-identify-heart-recipients-at-risk-for-development-of-severe-infections-a-multicenter-prospective-study
#9
Elizabeth Sarmiento, Maria Jaramillo, Leticia Calahorra, Juan Fernandez-Yañez, Miguel Gomez-Sanchez, Maria G Crespo-Leiro, Maria Paniagua, Luis Almenar, Monica Cebrian, Gregorio Rabago, Beltran Levy, Javier Segovia, Manuel Gomez-Bueno, Javier Lopez, Sonia Mirabet, Joaquin Navarro, Juan Jose Rodriguez-Molina, Eduardo Fernandez-Cruz, Javier Carbone
BACKGROUND: New biomarkers are necessary to improve detection of the risk of infection in heart transplantation. We performed a multicenter study to evaluate humoral immunity profiles that could better enable us to identify heart recipients at risk of severe infections. METHODS: We prospectively analyzed 170 adult heart recipients at 8 centers in Spain. Study points were before transplantation and 7 and 30 days after transplantation. Immune parameters included IgG, IgM, IgA and complement factors C3 and C4, and titers of specific antibody to pneumococcal polysaccharide antigens (anti-PPS) and to cytomegalovirus (CMV)...
October 17, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27865733/systolic-and-diastolic-unloading-by-mechanical-support-of-the-acute-vs-the-chronic-pressure-overloaded-right-ventricle
#10
Tom Verbelen, Daniel Burkhoff, Keiichiro Kasama, Marion Delcroix, Filip Rega, Bart Meyns
BACKGROUND: Right ventricular (RV) mechanical support is well described in cases of sudden increase in RV afterload. In cases of chronic RV pressure overload (e.g., pulmonary arterial hypertension), it has rarely been described. METHODS: The pulmonary artery was banded in 18 sheep. In the acute group (n = 9), we immediately implanted a Synergy Pocket Micro-Pump. Blood was withdrawn from the right atrium to the pulmonary artery. In the chronic group (n = 9), this pump was implanted 8 weeks after banding...
October 17, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27866929/long-term-outcomes-of-pulmonary-arterial-hypertension-under-specific-drug-therapy-in-eisenmenger-syndrome
#11
Sébastien Hascoët, Alban-Elouen Baruteau, Marc Humbert, Gérald Simonneau, Xavier Jais, Jérôme Petit, Daniela Laux, Olivier Sitbon, Virginie Lambert, André Capderou
BACKGROUND: The long-term effectiveness of pulmonary arterial hypertension-specific drug therapy (PAH-SDT) in Eisenmenger syndrome is controversial. We investigated short-term and long-term hemodynamic changes under PAH-SDT and their associations with outcomes in a bicentric cohort. METHODS: Over 20 years, we included 69 patients with congenital heart disease, an indexed pulmonary vascular resistance (PVRi) >8 WU·m(2), and 292 standardized catheterizations at baseline and after PAH-SDT initiation or intensification...
October 15, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27866925/extracorporeal-membrane-oxygenation-support-and-post-heart-transplant-outcomes-among-united-states-adults
#12
Sandip Zalawadiya, Marat Fudim, Geetha Bhat, William Cotts, JoAnn Lindenfeld
BACKGROUND: Patients supported with extracorporeal membrane oxygenation (ECMO) are given priority listing status for heart transplant (HT). Data on post-HT outcomes for adults with ECMO support at the time of HT are limited. METHODS: We analyzed data from the United Network for Organ Registry (UNOS) registry for 157 ECMO-supported adults (age ≥ 18 years) undergoing HT after January 1, 2000. Data at the time of HT were examined for their association with post-transplant mortality using multivariable Cox proportional hazard analyses...
October 15, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27876414/looking-on-the-bright-side-of-health-literacy-in-patients-with-cardiac-transplantation-where-are-we-and-where-do-we-need-to-go
#13
EDITORIAL
Colleen K McIlvennan
No abstract text is available yet for this article.
October 13, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27876281/post-transplant-surveillance-for-acute-rejection-and-allograft-vasculopathy-by-echocardiography-usefulness-of-myocardial-velocity-and-deformation-imaging
#14
Michael Dandel, Roland Hetzer
Diagnosing and monitoring acute rejection (AR) and cardiac allograft vasculopathy (CAV) is essential for graft and transplant patient survival and, consequently, a major objective for heart transplant patient surveillance. Because functionally relevant CAV can arise and progress without clinical symptoms and sub-clinical ARs can facilitate the development of CAV, standard surveillance of AR and CAV includes routine endomyocardial biopsy (EMB) and coronary angiography (CA) screenings at pre-defined time intervals...
October 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27865735/impact-of-age-on-incidence-and-prevalence-of-moderate-to-severe-cellular-rejection-detected-by-routine-surveillance-biopsy-in-pediatric-heart-transplantation
#15
Matthew D Zinn, Michael J Wallendorf, Kathleen E Simpson, Ashley D Osborne, James K Kirklin, Charles E Canter
BACKGROUND: The effect of age at transplant on rejection detected by routine surveillance biopsy (RSB) in pediatric heart transplant (HT) recipients is unknown. We hypothesized there would be low diagnostic yield and decreased prevalence of rejection detected on RSB in infants (age <1 year) when compared with children (age 1 to 9 years) and adolescents (age 10 to 18 years). METHODS: We utilized Pediatric Heart Transplant Study (PHTS) data from 2010 to 2013 to analyze moderate-to-severe (ISHLT Grade 2R/3R) cellular rejection (MSR) detected only on RSB (RSBMSR)...
October 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27863862/extracorporeal-membrane-oxygenation-with-multiple-organ-failure-can-molecular-adsorbent-recirculating-system-therapy-improve-survival
#16
Bailey E Sparks, Nicholas C Cavarocchi, Hitoshi Hirose
BACKGROUND: Liver dialysis, molecular adsorbent recirculating system (MARS) particularly, has been used in liver failure to bridge to transplantation. We expanded the indication for MARS to patients with acute shock liver failure and cardiopulmonary failure on extracorporeal membrane oxygenation (ECMO), aiming to improve survival to wean from ECMO. METHODS: Retrospective chart analysis of patients on ECMO between 2010 and 2015 found 28 patients who met the criteria for acute liver failure, diagnosed by hyperbilirubinemia (total bilirubin ≥10 mg/dl) or by elevated transaminase (alanine transaminase >1,000 IU/liter)...
October 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27863861/health-care-utilization-and-consequences-of-readmission-in-the-first-year-after-lung-transplantation
#17
Nathan M Mollberg, Eric Howell, David I Vanderhoff, Aaron Cheng, Michael S Mulligan
BACKGROUND: Hospital readmissions are costly and have become a focus for quality improvement. We aimed to determine risk factors, rate, and outcomes of readmissions within the first year after lung transplantation and the potential impact on patient survival. METHODS: A retrospective cohort study of all lung transplant recipients ≥18 years old who had undergone initial transplantation (2004-2013) at a single center was conducted. Logistic regression was used to identify independent predictors of readmission for patients who survived hospitalization...
October 7, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27865734/vascular-endothelial-growth-factor-a-is-associated-with-the-subsequent-development-of-moderate-or-severe-cardiac-allograft-vasculopathy-in-pediatric-heart-transplant-recipients
#18
Kevin P Daly, Maria Stack, Michele F Eisenga, John F Keane, David Zurakowski, Elizabeth D Blume, David M Briscoe
BACKGROUND: Cardiac allograft vasculopathy (CAV) is the leading cause of chronic allograft loss after pediatric heart transplantation. We hypothesized that biomarkers of endothelial injury and repair would predict CAV development in pediatric heart transplant recipients. METHODS: Blood was collected from pediatric heart transplant recipients at the time of routine annual coronary angiography, and the concentrations of 13 angiogenesis-related molecules were determined...
October 3, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27863863/effect-of-%C3%AE-2-adrenergic-receptor-stimulation-on-lung-fluid-in-stable-heart-failure-patients
#19
Bryan J Taylor, Eric M Snyder, Maile L Richert, Courtney M Wheatley, Steven C Chase, Lyle J Olson, Bruce D Johnson
BACKGROUND: The purpose of this study was to determine: (1) whether stable heart failure patients with reduced ejection fraction (HFrEF) have elevated extravascular lung water (EVLW) when compared with healthy control subjects; and (2) the effect of acute β2-adrenergic receptor (β2AR) agonist inhalation on lung fluid balance. METHODS: Twenty-two stable HFrEF patients and 18 age- and gender-matched healthy subjects were studied. Lung diffusing capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO), pulmonary capillary blood volume (Vc) (via re-breathe) and lung tissue volume (Vtis) (via computed tomography) were assessed before and within 30 minutes after administration of nebulized albuterol...
October 2, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27884629/urgent-listing-exceptions-and-outcomes-in-pediatric-heart-transplantation-comparison-to-standard-criteria-patients
#20
Ryan R Davies, Michael A McCulloch, Shylah Haldeman, Samuel S Gidding, Christian Pizarro
BACKGROUND: United Network for Organ Sharing (UNOS) policy enables listing exceptions to avoid penalizing patients with waitlist mortality not captured by standard criteria. Outcomes among patients listed by exception have not been analyzed. METHODS: We performed a retrospective analysis of pediatric (≤17 years of age, n = 4,706) listings (2006 to 2015) for primary, isolated heart transplantation within the UNOS data set, assessing Status 1A exception (n = 211, 4...
October 1, 2016: Journal of Heart and Lung Transplantation
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