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Journal of Heart and Lung Transplantation

Adaani E Frost, Marius M Hoeper, Joan Albert Barberá, Jean-Luc Vachiery, Christiana Blair, Jonathan Langley, Lewis J Rubin
BACKGROUND: The multinational AMBITION study demonstrated a 50% risk reduction in time to first clinical failure event (TtCF, a composite of death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) in treatment-naive Functional Class II and III PAH patients initiated on combination therapy (ambrisentan and tadalafil) vs monotherapy. A post-hoc analysis of AMBITION data by risk stratification, as determined by baseline REVEAL risk score, was undertaken to better assess the impact of combination therapy...
September 9, 2018: Journal of Heart and Lung Transplantation
Aditya Bansal, Mandeep R Mehra
No abstract text is available yet for this article.
September 8, 2018: Journal of Heart and Lung Transplantation
Nadia Bouabdallaoui, Ismail El-Hamamsy, Magali Pham, Genevieve Giraldeau, Marie-Claude Parent, Michel Carrier, Jean L Rouleau, Anique Ducharme
Aortic regurgitation (AR) developing while using a continuous-flow left ventricular assist device (CF-LVAD) affects 25% to 30% of patients within the first year of implantation and is increasingly being recognized as a cause of recurrence of symptomatic heart failure (HF). The underlying mechanisms are likely multifactorial, including changes in the leaflets of the aortic valve (AV), altered root biomechanics, and excessive left ventricular (LV) unloading, together promoting cusp remodeling and commissural fusion...
September 6, 2018: Journal of Heart and Lung Transplantation
Anna Apostolo, Stefania Paolillo, Mauro Contini, Carlo Vignati, Vincenzo Tarzia, Jeness Campodonico, Massimo Mapelli, Massimo Massetti, Jonida Bejko, Francesca Righini, Tomaso Bottio, Niccolò Bonini, Elisabetta Salvioni, Paola Gugliandolo, Gianfranco Parati, Carolina Lombardi, Gino Gerosa, Luca Salvi, Francesco Alamanni, Piergiuseppe Agostoni
BACKGROUND: Increasing left ventricular assist device (LVAD) pump speed according to the patient's activity is a fascinating hypothesis. This study analyzed the short-term effects of LVAD speed increase on cardiopulmonary exercise test (CPET) performance, muscle oxygenation (near-infrared spectroscopy), diffusion capacity of the lung for carbon monoxide (Dlco) and nitric oxide (Dlno), and sleep quality. METHODS: We analyzed CPET, Dlco and Dlno, and sleep in 33 patients supported with the Jarvik 2000 (Jarvik Heart Inc...
September 5, 2018: Journal of Heart and Lung Transplantation
Kohei Hashimoto, Konrad Hoetzenecker, Jonathan C Yeung, Luke Jeagal, Laura Donahoe, Andrew Pierre, Marc de Perrot, Kazuhiro Yasufuku, Thomas K Waddell, Shaf Keshavjee, Marcelo Cypel
BACKGROUND: Venovenous (VV) extracorporeal membrane oxygenation (ECMO) is the preferred configuration for bridging respiratory failure patients while awaiting lung transplantation. However, there is no consensus on intraoperative extracorporeal cardiopulmonary support during lung transplantation in these patients. METHODS: The configuration of the intraoperative extracorporeal circuit after VV ECMO bridge was reviewed and correlated with clinical outcomes. This retrospective cohort study performed at our university hospital included 34 patients who were successfully bridged solely with VV ECMO to lung transplantation during the period 2007 to 2016...
September 5, 2018: Journal of Heart and Lung Transplantation
Misato Chimura, Tomohito Ohtani, Yasumasa Tsukamoto, Hidetaka Kioka, Themistoklis Katsimichas, Toshinari Onishi, Kei Nakamoto, Shozo Konishi, Kaoruko Sengoku, Hiroshi Miyawaki, Shungo Hikoso, Osamu Yamaguchi, Yasushi Sakata
BACKGROUND: Treatment decisions in dilated cardiomyopathy (DCM) patients with severe heart failure (HF) and short clinical history are challenging because of the difficulty of determining HF stage or prognosis in the acute HF phase. We hypothesized that persistent decreased systemic or increased pulmonary arterial pressure, including in the sub-clinical phase, might affect the main pulmonary artery diameter (PAD), ascending aortic diameter (AoD), and their ratio (PAD/AoD). This study assessed AoD, PAD, and PAD/AoD by non-contrast computed tomography scans in DCM patients in the acute phase of HF and examined the association of these parameters with their clinical course...
August 30, 2018: Journal of Heart and Lung Transplantation
Jonathan N Menachem, Joann Lindenfeld, Kelly Schlendorf, Ashish S Shah, David P Bichell, Wendy Book, D Marshall Brinkley, Matthew Danter, Benjamin Frischhertz, Mary Keebler, Brian Kogon, Bret Mettler, Joseph Rossano, Suzanne Brown Sacks, Thomas Young, Mark Wigger, Sandip Zalawadiya
BACKGROUND: The number of adult congenital heart disease (ACHD) patients requiring heart transplantation (HT) continues to grow, and if they survive the first year after transplant, their long-term survival is at least equivalent to non-ACHD patients. The 1-year survival of ACHD patients with HT remains lower than non-ACHD patients. We evaluated the affect of transplant center volume on 1-year survival of ACHD patients. We analyzed United Network of Organ Sharing patients (age ≥18 years) who underwent their first orthotopic HT between January 1, 2000, and December 31, 2015, to assess the association between transplant center volume and 1-year survival of ACHD patients...
August 30, 2018: Journal of Heart and Lung Transplantation
Rabea Asleh, Alexandros Briasoulis, Naveen L Pereira, Brooks S Edwards, Robert P Frantz, Richard C Daly, Amir Lerman, Sudhir S Kushwaha
BACKGROUND: Sirolimus (SRL) attenuates cardiac allograft vasculopathy (CAV) progression after heart transplantation (HT) but often results in hyperlipidemia. In this study we investigated the differential effects of SRL-based and calcineurin inhibitor (CNI)-based immunosuppression on CAV progression and clinical outcomes in HT recipients. METHODS: CAV progression was assessed by coronary intravascular ultrasound (IVUS) as changes in volumetric measurements after correction to time between the first and last follow-up IVUS exams...
August 30, 2018: Journal of Heart and Lung Transplantation
Mandeep R Mehra, Christopher Salerno, Yoshifumi Naka, Nir Uriel, Joseph C Cleveland, Douglas Horstmanshof, Daniel J Goldstein
No abstract text is available yet for this article.
August 24, 2018: Journal of Heart and Lung Transplantation
Jacob Lavee, Johanna Mulzer, Thomas Krabatsch, Silvana Marasco, David McGiffin, Jens Garbade, Jan D Schmitto, Daniel Zimpfer, Evgenij V Potapov
Significant right ventricular failure accompanying left ventricular failure was treated by implantation of the fully magnetically levitated centrifugal HeartMate 3 ventricular assist device as biventricular (BiVAD) support in 14 patients at 6 medical centers worldwide. The clinical details of this first multicenter experience are presented. Nine of these patients (64%) were alive as of January 1, 2018. Eight of the 9 have continued on BiVAD support for 95 to 636 (mean 266) days: 7 at home, and 1 successfully transplanted after 98 days of support...
August 17, 2018: Journal of Heart and Lung Transplantation
Don Hayes, Hemant Parekh, Peter B Baker
No abstract text is available yet for this article.
August 17, 2018: Journal of Heart and Lung Transplantation
Eshita Singh, Marc Schecter, Christopher Towe, Raheel Rizwan, Bryant Roosevelt, James Tweddell, M Monir Hossain, David Morales, Farhan Zafar
BACKGROUND: Lung donor utilization rates remain low, with many organs refused for donor quality. However, some centers have successfully transplanted these organs despite multiple refusals for donor quality (RDQs) by other centers. We hypothesized that the number of refusals due to donor quality does not impact post-transplant outcomes. METHODS: Lung transplants (LTxs) from 2006 to 2015, identified using the United Network for Organ Sharing (UNOS) database, were matched against the potential transplant recipient (PTR) data set by donor identification...
August 17, 2018: Journal of Heart and Lung Transplantation
Snehal R Patel, Shivank Madan, Omar Saeed, Daniel B Sims, J Julia Shin, Cecilia Nucci, Edward Borukhov, Doctor Y Goldstein, William Jakobleff, Stephen Forest, Sasa Vukelic, Sandhya Murthy, John Reinus, Yoram Puius, Daniel J Goldstein, Ulrich P Jorde
BACKGROUND: Hepatitis C (HCV) donors are rarely used for cardiac transplantation due to historically poor outcomes. In 2015, nucleic acid testing (NAT) for viral load was added to the routine work-up of organ donors, allowing for the distinction between subjects who remain viremic (HCV Ab+ /NAT+ ) and those who have cleared HCV and are no longer viremic (HCV Ab+ /NAT- ). The American Society of Transplantation recently recommended that HCV Ab+ /NAT- donors be considered non-infectious and safe for transplantation...
August 17, 2018: Journal of Heart and Lung Transplantation
Bronwyn Levvey, Shaf Keshavjee, Marcelo Cypel, Amanda Robinson, Michael Erasmus, Allan Glanville, Peter Hopkins, Michael Musk, Marshall Hertz, Kenneth McCurry, Dirk Van Raemdonck, Gregory Snell
BACKGROUND: In this study we aimed to assess the impact of agonal time and warm ischemic time on early survival in Category III donation-after-circulatory-death (DCD) donor lung transplants (LTxs) using data reported to the International Society for Heart and Lung Transplantation (ISHLT) DCD Lung Transplant Registry. METHODS: In this retrospective study, data were analyzed for 507 DCD LTxs done between January 2005 and June 2015. DCD lung donor agonal time (defined as withdrawal of life support to cessation of cardiac output) and warm ischemic time (WIT; defined as donor systolic blood pressure <50mm Hg to cold pulmonary artery flush) were divided into 3 clinical timing categories (<30 minutes, 30 to 60 minutes, >60 minutes) and 3 tertiles...
August 11, 2018: Journal of Heart and Lung Transplantation
Oliver Miera, Matthias Germann, My Y Cho, Joachim Photiadis, Eva M Delmo Walter, Roland Hetzer, Felix Berger, Katharina R L Schmitt
BACKGROUND: The majority of children supported with ventricular assist devices (VADs) are bridged to heart transplantation. Although bridge to recovery has been reported, low recovery patient numbers has precluded systematic analysis. The aim of this study was to delineate recovery rates and predictors of recovery and to report on long-term follow-up after VAD explantation in children. METHODS: Children bridged to recovery at our institution from January 1990 to May 2016 were compared with a non-recovery cohort...
August 11, 2018: Journal of Heart and Lung Transplantation
Benjamin H Waters, Jiheum Park, J Christopher Bouwmeester, John Valdovinos, Arnar Geirsson, Alanson P Sample, Joshua R Smith, Pramod Bonde
BACKGROUND: Models of power delivery within an intact organism have been limited to ionizing radiation and, to some extent, sound and magnetic waves for diagnostic purposes. Traditional electrical power delivery within the intact human body relies on implanted batteries that limit the amount and duration of delivered power. The efficiency of current battery technology limits the substantial demands required, such as continuous operation of an implantable artificial heart pump within a human body...
August 11, 2018: Journal of Heart and Lung Transplantation
Henrik Auråen, Hans Henrik L Schultz, Pekka Hämmäinen, Gerdt C Riise, Hillevi Larsson, Lennart Hansson, Göran Dellgren, Michael Perch, Odd Geiran, Arnt E Fiane, Martin Iversen, Are Martin Holm
BACKGROUND: Throughout the world, the scarcity of donor organs makes optimal allocation systems necessary. In the Scandiatransplant countries, organs for lung transplantation are allocated nationally. To ensure shorter wait time for critically ill patients, the Scandiatransplant urgent lung allocation system (ScULAS) was introduced in 2009, giving supranational priority to patients considered urgent. There were no pre-defined criteria for listing a patient as urgent, but each center was granted only 3 urgent calls per year...
August 8, 2018: Journal of Heart and Lung Transplantation
Mark Anderson, D Lynn Morris, Daniel Tang, George Batsides, Ajay Kirtane, Ivan Hanson, Perwais Meraj, Navin Kapur, William O'Neill
BACKGROUND: Right ventricular failure (RVF) after myocardial infarction, cardiotomy, or left ventricular assist device (LVAD) implantation increases morbidity and mortality. RVF also contributes to prolonged length of hospital stay and higher costs of care. The aim of this study was to evaluate the efficacy and safety of the Impella RP (Abiomed, Danvers, MA) in patients with severe RVF in these clinical settings. METHODS: This is a prospective cohort study of patients with severe RVF treated with a percutaneous right ventricular assist device (RVAD)...
August 8, 2018: Journal of Heart and Lung Transplantation
Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis
No abstract text is available yet for this article.
August 8, 2018: Journal of Heart and Lung Transplantation
Francis D Pagani
No abstract text is available yet for this article.
August 7, 2018: Journal of Heart and Lung Transplantation
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