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Journal of Heart and Lung Transplantation

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https://www.readbyqxmd.com/read/29655662/evaluation-of-low-intensity-anti-coagulation-with-a-fully-magnetically-levitated-centrifugal-flow-circulatory-pump-the-magentum-1-study
#1
Ivan Netuka, Peter Ivák, Zuzana Tučanová, Stanislav Gregor, Ondrej Szárszoi, Poornima Sood, Daniel Crandall, Jessica Rimsans, Jean Marie Connors, Mandeep R Mehra
BACKGROUND: The HeartMate 3 left ventricular assist system is engineered to avoid pump thrombosis, yet bleeding complications persist. We investigated the safety of low-intensity anti-coagulation in patients with the HeartMate 3. METHODS: The Minimal AnticoaGulation EvaluatioNTo aUgment heMocompatibility (MAGENTUM 1) pilot study is a prospective, single-arm study of low-intensity warfarin anti-coagulation in patients implanted with the HeartMate 3 pump. After standard warfarin anti-coagulation (international normalized ratio [INR] 2...
March 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29678608/clinical-and-hemodynamic-effects-of-intra-aortic-balloon-pump-therapy-in-chronic-heart-failure-patients-with-cardiogenic-shock
#2
Justin A Fried, Abhinav Nair, Koji Takeda, Kevin Clerkin, Veli K Topkara, Amirali Masoumi, Melana Yuzefpolskaya, Hiroo Takayama, Yoshifumi Naka, Daniel Burkhoff, Ajay Kirtane, S M Dimitrios Karmpaliotis, Jeffrey Moses, Paolo C Colombo, A Reshad Garan
BACKGROUND: The role of the intra-aortic balloon pump (IABP) in acute decompensated heart failure (HF) with cardiogenic shock (CS) is largely undefined. In this study we sought to assess the hemodynamic and clinical response to IABP in chronic HF patients with CS and identify predictors of response to this device. METHODS: We retrospectively reviewed all patients undergoing IABP implantation from 2011 to 2016 at our institution to identify chronic HF patients with acute decompensation and CS (cardiac index <2...
March 20, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29571601/high-circulating-cd4-cd25-hi-foxp3-t-cell-sub-population-early-after-lung-transplantation-is-associated-with-development-of-bronchiolitis-obliterans-syndrome
#3
Maxim Durand, Philippe Lacoste, Richard Danger, Lola Jacquemont, Carole Brosseau, Eugénie Durand, Gaelle Tilly, Jennifer Loy, Aurore Foureau, Pierre-Joseph Royer, Adrien Tissot, Antoine Roux, Martine Reynaud-Gaubert, Romain Kessler, Sacha Mussot, Claire Dromer, Olivier Brugière, Jean François Mornex, Romain Guillemain, Johanna Claustre, Nicolas Degauque, Antoine Magnan, Sophie Brouard
BACKGROUND: Chronic bronchiolitis obliterans syndrome (BOS) remains a major limitation for long-term survival after lung transplantation. The immune mechanisms involved and predictive biomarkers have yet to be identified. The purpose of this study was to determine whether peripheral blood T-lymphocyte profile could predict BOS in lung transplant recipients. METHODS: An in-depth profiling of CD4+ and CD8+ T cells was prospectively performed on blood cells from stable (STA) and BOS patients with a longitudinal follow-up...
March 20, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29680587/azathioprine-to-mycophenolate-mofetil-transition-and-risk-of-squamous-cell-carcinoma-after-lung-transplantation
#4
Martin Vos, Elsemieke I Plasmeijer, Barbara C van Bemmel, Wim van der Bij, Nina S Klaver, Michiel E Erasmus, Geertruida H de Bock, Erik A M Verschuuren, Emőke Rácz
BACKGROUND: Chronic immunosuppression after solid-organ transplantation is a risk factor for cutaneous squamous cell carcinoma (cSCC) development. Certain immunosuppressant drugs, namely azathioprine and calcineurin inhibitors, increase this risk more than others. We investigated incidence of cSCC in a Dutch lung transplant recipient (LTR) cohort and analyzed associated risk factors. METHODS: All LTRs with post-transplant survival of >30 days were included. Data included indication for lung transplantation and duration of medication use...
March 19, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29627142/double-jeopardy-competing-arrhythmias-in-heterotopic-heart-transplants
#5
LETTER
Elizabeth D Paratz, James L Hare, David M Kaye
No abstract text is available yet for this article.
March 19, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29653800/use-of-supplemental-oxygen-in-patients-with-pulmonary-arterial-hypertension-in-reveal
#6
Harrison W Farber, David B Badesch, Raymond L Benza, C Gregory Elliott, Robert P Frantz, Michael D McGoon, Mona Selej, Carol Zhao, Adaani E Frost
BACKGROUND: Supplemental low-flow oxygen is recommended by treatment guidelines as supportive therapy for patients with pulmonary arterial hypertension (PAH), based largely on expert opinion. Reduced diffusing capacity of lung carbon monoxide (DLCO) is associated with increased mortality in PAH. Reduced DLCO is also associated with relative hypoxemia, making the effects of supplemental oxygen use of particular interest in this sub-population. METHODS: Patients in the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL), a 5-year observational study of Group 1 PAH, were categorized by presence or absence of supplemental oxygen use and by degree of DLCO reduction...
March 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29650295/acquired-von-willebrand-syndrome-and-impaired-platelet-function-during-venovenous-extracorporeal-membrane-oxygenation-rapid-onset-and-fast-recovery
#7
Johannes Kalbhenn, Axel Schlagenhauf, Simone Rosenfelder, Axel Schmutz, Barbara Zieger
BACKGROUND: Bleeding contributes to the high mortality of venovenous extracorporeal membrane oxygenation (vvECMO). The development of acquired von Willebrand syndrome (AVWS) has been identified as relevant pathology during ECMO. This study was performed to determine the onset of AVWS after implantation and the recovery of von Willebrand factor (VWF) parameters after explantation of ECMO in a large cohort of patients. METHODS: VWF parameters of 59 patients treated with vvECMO at a university ECMO center were obtained before ECMO implantation, during therapy, and after explantation...
March 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29628135/lung-transplantation-for-scleroderma-lung-disease-an-international-multicenter-observational-cohort-study
#8
Pauline Pradère, Igor Tudorache, Jesper Magnusson, Laurent Savale, Olivier Brugiere, Benoît Douvry, Martine Reynaud-Gaubert, Johanna Claustre, Aurélie Le Borgne, Are M Holm, Hans Henrik Schultz, Christiane Knoop, Laurent Godinas, Andrew J Fisher, Sandrine Hirschi, Jens Gottlieb, Jérôme Le Pavec
BACKGROUND: Due to its multisystemic nature, scleroderma is considered a relative contraindication to lung transplantation at many centers. However, recent studies suggest similar post-transplant outcomes in patients with scleroderma compared to those with other causes of interstitial lung disease (ILD). Furthermore, it remains unknown whether scleroderma-associated pulmonary arterial hypertension (PAH) influences post-transplant outcomes. Our objective in this study was to assess the indications, survival, and prognostic factors of lung or heart-lung transplantation for scleroderma lung disease...
March 15, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29609844/does-vaccination-in-solid-organ-transplant-recipients-result-in-adverse-immunologic-sequelae-a-systematic-review-and-meta-analysis
#9
William R Mulley, Claire Dendle, Jonathan E H Ling, Simon R Knight
BACKGROUND: Clinical guidelines recommend vaccinations for solid-organ transplant recipients. However, concern exists that vaccination may stimulate adverse alloimmune responses. METHODS: We systematically reviewed the published literature regarding this aspect of vaccine safety. Electronic databases were searched for interventional and observational studies assessing de novo donor-specific antibodies (DSA) and rejection episodes after vaccination against infectious pathogens...
March 10, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29580746/reveal-risk-score-in-patients-with-chronic-thromboembolic-pulmonary-hypertension-receiving-riociguat
#10
Raymond L Benza, Harrison W Farber, Adaani Frost, Ekkehard Grünig, Marius M Hoeper, Dennis Busse, Christian Meier, Sylvia Nikkho, Hossein-Ardeschir Ghofrani
BACKGROUND: The REVEAL risk score (RRS) was developed to predict survival in patients with pulmonary arterial hypertension (PAH), based on multiple patient characteristics. Herein we calculated RRS for patients in the randomized CHEST-1 study and open-label CHEST-2 extension study of riociguat in inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH). We investigated the effect of riociguat vs placebo on RRS in the CHEST-1 study, and the relationship between RRS and long-term outcomes in the CHEST-2 study...
March 1, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29628136/balancing-decisions-in-mechanical-circulatory-support-it-s-all-in-the-timing
#11
EDITORIAL
Christopher S Hayward
No abstract text is available yet for this article.
February 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29602706/baseline-lung-allograft-dysfunction-is-associated-with-impaired-survival-after-double-lung-transplantation
#12
Jonathan Liu, Kathy Jackson, Justin Weinkauf, Ali Kapasi, Alim Hirji, Steve Meyer, John Mullen, Jayan Nagendran, Dale Lien, Kieran Halloran
BACKGROUND: The prognostic value of defining normal vs abnormal baseline post-transplant lung function (or baseline lung allograft dysfunction [BLAD]) has not been studied using standardized reference values of percent predicted of the population. Our aim was to assess the association between BLAD and survival in double-lung transplant recipients and assess for potential pre-transplant donor and recipient risk factors for BLAD. METHODS: We conducted a retrospective cohort study of double-lung transplant recipients in our program during the period 2004 to 2009...
February 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29573903/response-to-effects-of-pre-load-variations-on-hemodynamic-parameters-with-a-pulsatile-autoregulated-artificial-heart-during-the-early-post-operative-period
#13
LETTER
Rinku Skaria, Zain Khalpey
No abstract text is available yet for this article.
February 21, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29550148/the-right-patients-for-temporary-mechanical-circulatory-support
#14
LETTER
Hoong Sern Lim
No abstract text is available yet for this article.
February 21, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29525103/optimization-of-oxygenation-during-ex-vivo-lung-perfusion-best-basic-science-article-in-2017
#15
LETTER
Ciara M Shaver, Joshua M Diamond, Sonja Schrepfer, Edward Cantu
No abstract text is available yet for this article.
February 21, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29550147/neuropsychological-outcomes-after-pulmonary-endarterectomy-using-moderate-hypothermia-and-periodic-circulatory-arrest
#16
Benedetta Vanini, Valentina Grazioli, Antonio Sciortino, Maurizio Pin, Vera N Merli, Anna Celentano, Ilaria Parisi, Catherine Klersy, Lucia Petrucci, Maurizio Salati, Pierluigi Politi, Andrea M D'Armini
BACKGROUND: In this prospective, single-center, observational study, we investigated the association between repeated short periods of circulatory arrest with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions. METHODS: We examined 70 patients with CTEPH, >18 to 80 years of age, who had been treated with PEA. Neuropsychological testing was performed...
February 19, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29519740/peri-operative-desensitization-a-promising-strategy-for-overcoming-the-antibody-barrier-in-heart-transplantation
#17
EDITORIAL
Jignesh K Patel
No abstract text is available yet for this article.
February 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29571602/heart-failure-after-the-norwood-procedure-an-analysis-of-the-single-ventricle-reconstruction-trial
#18
William T Mahle, Chenwei Hu, Felicia Trachtenberg, JonDavid Menteer, Steven J Kindel, Anne I Dipchand, Marc E Richmond, Kevin P Daly, Heather T Henderson, Kimberly Y Lin, Michael McCulloch, Ashwin K Lal, Kurt R Schumacher, Jeffrey P Jacobs, Andrew M Atz, Chet R Villa, Kristin M Burns, Jane W Newburger
BACKGROUND: Heart failure results in significant morbidity and mortality in young children with hypoplastic left heart syndrome (HLHS) after the Norwood procedure. METHODS: We studied subjects enrolled in the prospective Single Ventricle Reconstruction (SVR) Trial who survived to hospital discharge after a Norwood operation and were followed up to age 6 years. The primary outcome was heart failure, defined as heart transplant listing after Norwood hospitalization, death attributable to heart failure, or symptomatic heart failure (New York Heart Association [NYHA] Class IV)...
February 16, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29548625/a-strategy-for-prevention-of-fungal-infections-in-lung-transplantation-role-of-bronchoalveolar-lavage-fluid-galactomannan-and-fungal-culture
#19
Shahid Husain, Archana Bhaskaran, Coleman Rotstein, Yanhong Li, Alyajahan Bhimji, Rhea Pavan, Deepali Kumar, Atul Humar, Shaf Keshavjee, Lianne G Singer
BACKGROUND: The optimal strategy for prevention of invasive fungal infections in lung transplant recipients remains undetermined. We studied strategies based on bronchoalveolar lavage fungal culture and galactomannan for prevention of invasive aspergillosis in lung transplant recipients. METHODS: Consecutive lung transplant recipients were evaluated during the period January 2010 to September 2014. Rates of invasive aspergillosis and all-cause mortality were recorded at 1 year...
February 16, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29482931/prognostic-relevance-of-appropriate-renal-function-evaluation-in-pulmonary-arterial-hypertension
#20
EDITORIAL
Jose Leonidas Alves, Rogerio Souza
No abstract text is available yet for this article.
February 9, 2018: Journal of Heart and Lung Transplantation
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