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Journal of Heart and Lung Transplantation

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https://www.readbyqxmd.com/read/28720213/professor-christian-cabrol-1925-to-2017
#1
EDITORIAL
Jack Copeland
No abstract text is available yet for this article.
July 8, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28712677/extracorporeal-membrane-oxygenation-following-lung-transplantation-indications-and-survival
#2
Michael S Mulvihill, Babatunde A Yerokun, Robert Patrick Davis, David N Ranney, Mani A Daneshmand, Matthew G Hartwig
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is employed to rescue patients with early graft dysfunction after lung transplantation (LTx). Rates of post-LTx ECMO and subsequent outcomes have been limited to single-center reports. METHODS: UNOS registry was queried for LTx recipients from March 2015 to March 2016; 2,001 recipients were identified and stratified by need for post-LTx ECMO. Logistic regression was used to determine variables associated with post-LTx ECMO...
July 1, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28711453/a-roadmap-for-evaluating-the-use-and-value-of-durable-ventricular-assist-device-therapy
#3
EDITORIAL
Sarah T Ward, Qixing Liang, Francis D Pagani, Min Zhang, Robert L Kormos, Keith D Aaronson, Andrew D Althouse, Brahmajee K Nallamothu, Donald S Likosky
Heart failure is a disease characterized by profound human suffering with limitations in survival despite treatment with guideline-directed medical therapies. Patients with heart failure frequently progress to advanced stages and often require cardiac transplantation or implantation of left ventricular assist devices (LVADs) to extend survival and improve quality of life. As the number of suitable heart donors, number of experienced medical centers and patient comorbidities place restrictions on the feasibility of cardiac transplantation, implantation of LVADs has emerged as a more frequently applied treatment as either a bridge to transplantation or as permanent therapy...
June 23, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28705646/reverse-histologic-remodeling-after-mechanical-unloading-of-failing-hearts-in-children-with-dilated-cardiomyopathy
#4
LETTER
Jennifer Kasten, Dinesh Rakheja, Song Zhang, Poonam Thankavel, Bibhuti B Das
No abstract text is available yet for this article.
June 23, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28705645/assessing-the-impact-of-program-volume-and-composition-on-waiting-list-outcomes-in-pediatric-lung-transplantation
#5
EDITORIAL
Stuart C Sweet
No abstract text is available yet for this article.
June 21, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28689646/higher-m30-and-high-mobility-group-box-1-protein-levels-in-ex-vivo-lung-perfusate-are-associated-with-primary-graft-dysfunction-after-human-lung-transplantation
#6
Kohei Hashimoto, Marcelo Cypel, Stephen Juvet, Tomohito Saito, Ricardo Zamel, Tiago N Machuca, Michael Hsin, Hyunhee Kim, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ex vivo lung perfusion (EVLP) enables assessment of marginal donor lungs for transplantation, with similar clinical outcomes to conventional lung transplantation. We investigated whether cell death-related proteins in the EVLP perfusate could predict primary graft dysfunction (PGD) after transplantation. METHODS: M30 (indicating epithelial apoptosis), M65 (indicating total epithelial cell death), and high mobility group box 1 (HMGB-1, related to cell death and inflammation) protein levels in EVLP perfusate were measured by enzyme-linked immunosorbent assay and correlated with clinical outcomes...
June 21, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28668192/intraoperative-processing-and-epicardial-transplantation-of-autologous-atrial-tissue-for-cardiac-repair
#7
LETTER
Milla Lampinen, Annu Nummi, Tuomo Nieminen, Ari Harjula, Esko Kankuri
No abstract text is available yet for this article.
June 10, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28651907/tumor-necrosis-factor-%C3%AE-levels-and-non-surgical-bleeding-in-continuous-flow-left-ventricular-assist-devices
#8
Corey E Tabit, Mitchell J Coplan, Phetcharat Chen, Valluvan Jeevanandam, Nir Uriel, James K Liao
BACKGROUND: Non-surgical bleeding (NSB) due to angiodysplasia is common in left ventricular assist device (LVAD) patients. Thrombin-induced angiopoietin-2 (Ang-2) expression in LVAD patients leads to altered angiogenesis and is associated with lower angiopoietin-1 (Ang-1) and increased NSB. However, the mechanism for decreased Ang-1, made by pericytes, is unknown and the origin of thrombin in LVAD patients is unclear. We hypothesized that high tumor necrosis factor-α (TNF-α) levels in LVAD patients induce pericyte apoptosis, tissue factor (TF) expression and vascular instability...
June 8, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28720212/changing-the-curve-in-chronic-lung-allograft-dysfunction-implications-of-chronic-lung-allograft-dysfunction-phenotypes-in-assessing-treatment-interventions
#9
EDITORIAL
Joshua J Mooney
No abstract text is available yet for this article.
May 29, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28662986/therapy-options-for-chronic-lung-allograft-dysfunction-bronchiolitis-obliterans-syndrome-following-first-line-immunosuppressive-strategies-a-systematic-review
#10
Christian Benden, Maria Haughton, Saoirse Leonard, Lars C Huber
BACKGROUND: Long-term success of lung transplantation is limited by the development of chronic lung allograft dysfunction (CLAD), of which bronchiolitis obliterans syndrome (BOS) is the most common form. This systematic review sought to identify the current evidence base for CLAD-BOS therapies after initial immunosuppressive treatment strategies. METHODS: The MEDLINE, Embase, and Cochrane Library databases from inception to May 3, 2016, were searched using keywords relating to CLAD-BOS, study designs, and treatments of interest, including extracorporeal photopheresis (ECP), aerosolized cyclosporine, total lymphoid irradiation (TLI), alemtuzumab, and montelukast...
May 29, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28662985/building-a-tissue-based-molecular-diagnostic-system-in-heart-transplant-rejection-the-heart-molecular-microscope-diagnostic-mmdx-system
#11
Philip F Halloran, Luciano Potena, Jean-Paul Duong Van Huyen, Patrick Bruneval, Ornella Leone, Daniel H Kim, Xavier Jouven, Jeff Reeve, Alexandre Loupy
BACKGROUND: The emergence of molecular systems offers opportunities for improving the assessment of rejection in heart transplant biopsy specimens. The present study developed a microarray-based system for assessing heart transplant endomyocardial biopsy (EMB) specimens. METHODS: We analyzed 331 protocol or for-cause EMB specimens from 221 subjects in 3 centers (Edmonton, Bologna, and Paris). Unsupervised principal component analysis (PCA) and archetype analysis used rejection-associated transcripts (RATs) shown in kidney transplants to be associated with antibody-mediated rejection (ABMR) or T cell-mediated rejection (TCMR), or both...
May 29, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28642001/regarding-mechanical-circulatory-support-in-adults-with-congenital-heart-disease-is-it-time-to-lower-the-threshold-for-use
#12
EDITORIAL
Roosevelt Bryant, David L S Morales
No abstract text is available yet for this article.
May 29, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28599875/statins-in-lung-transplantation-a-treatment-option-for-every-patient
#13
EDITORIAL
Geert M Verleden, Robin Vos
No abstract text is available yet for this article.
May 25, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28619383/cardiac-rehabilitation-and-readmissions-after-heart-transplantation
#14
Justin M Bachmann, Ashish S Shah, Meredith S Duncan, Robert A Greevy, Amy J Graves, Shenghua Ni, Henry H Ooi, Thomas J Wang, Randal J Thomas, Mary A Whooley, Matthew S Freiberg
BACKGROUND: Exercise-based cardiac rehabilitation (CR) is under-utilized. CR is indicated after heart transplantation, but there are no data regarding CR participation in transplant recipients. We characterized current CR utilization among heart transplant recipients in the United States and the association of CR with 1-year readmissions using the 2013-2014 Medicare files. METHODS: The study population included Medicare beneficiaries enrolled due to disability (patients on the transplant list are eligible for disability benefits under Medicare regulations) or age ≥65 years...
May 23, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28666570/dead-space-ventilation-is-linked-to-exercise-capacity-and-survival-in-distal-chronic-thromboembolic-pulmonary-hypertension
#15
Laurent Godinas, Caroline Sattler, Edmund M Lau, Xavier Jaïs, Yu Taniguchi, Mitja Jevnikar, Jason Weatherald, Olivier Sitbon, Laurent Savale, David Montani, Gérald Simonneau, Marc Humbert, Pierantonio Laveneziana, Gilles Garcia
BACKGROUND: Cardiopulmonary exercise testing (CPET) is frequently used for the evaluation of patients with pulmonary hypertension (PH). Non-operable distal chronic thromboembolic pulmonary hypertension (CTEPH) represents a unique subgroup of PH where microvascular disease resembling pulmonary arterial hypertension (PAH) may predominate and efficacious medical therapy is now available. However, little is known regarding the detailed CPET profile of patients with distal CTEPH, and whether ventilation and gas exchange responses are different from PAH...
May 22, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28666571/usefulness-of-2-centrifugal-ventricular-assist-devices-in-a-total-artificial-heart-configuration-a-preliminary-report
#16
LETTER
Michael S Mulvihill, Jeremy T Joseph, Mani A Daneshmand, Chetan B Patel, Carmelo A Milano, Jacob N Schroder
No abstract text is available yet for this article.
May 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28662987/changes-in-disease-specific-versus-generic-health-status-measures-after-left-ventricular-assist-device-implantation-insights-from-intermacs
#17
Michael E Nassif, John A Spertus, Philip G Jones, Timothy J Fendler, Larry A Allen, Kathleen L Grady, Suzanne V Arnold
BACKGROUND: Quantifying quality of life (QoL) after left ventricular assist device (LVAD) remains challenging. Heart failure (HF)-specific health status measures are ideal for assessing symptoms of HF; however, if patients' QoL is limited by other factors, they may experience improved HF-specific QoL but no concurrent improvement in generic QoL. We sought to examine and predict discrepancies between disease-specific and generic QoL measures after LVAD. METHODS: We examined HF-specific and generic QoL with the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQol-5D Visual Analog Scale (VAS), respectively, among 1,888 patients with advanced heart failure who underwent LVAD implantation from 2012 to 2014 as part of the INTERMACS registry...
May 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28642000/initial-experience-with-the-heartmate-percutaneous-heart-pump-in-circulatory-failure
#18
LETTER
Jiri Maly, Peter Ivak, Ivan Netuka, Ales Herman, Jiri Kettner, Poornima Sood, Ulrich P Jorde
No abstract text is available yet for this article.
May 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28624139/applying-rigor-and-reproducibility-standards-to-assay-donor-derived-cell-free-dna-as-a-non-invasive-method-for-detection-of-acute-rejection-and-graft-injury-after-heart-transplantation
#19
Sean Agbor-Enoh, Ilker Tunc, Iwijn De Vlaminck, Ulgen Fideli, Andrew Davis, Karen Cuttin, Kenneth Bhatti, Argit Marishta, Michael A Solomon, Annette Jackson, Grace Graninger, Bonnie Harper, Helen Luikart, Jennifer Wylie, Xujing Wang, Gerald Berry, Charles Marboe, Kiran Khush, Jun Zhu, Hannah Valantine
BACKGROUND: Use of new genomic techniques in clinical settings requires that such methods are rigorous and reproducible. Previous studies have shown that quantitation of donor-derived cell-free DNA (%ddcfDNA) by unbiased shotgun sequencing is a sensitive, non-invasive marker of acute rejection after heart transplantation. The primary goal of this study was to assess the reproducibility of %ddcfDNA measurements across technical replicates, manual vs automated platforms, and rejection phenotypes in distinct patient cohorts...
May 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28606584/impact-of-a-modified-anti-thrombotic-guideline-on-stroke-in-children-supported-with-a-pediatric-ventricular-assist-device
#20
David N Rosenthal, Chacy A Lancaster, Doff B McElhinney, Sharon Chen, MaryLyn Stein, Aileen Lin, Lan Doan, Jenna M Murray, Mary Alice Gowan, Katsuhide Maeda, Olaf Reinhartz, Christopher S Almond
BACKGROUND: Stroke is the most feared complication associated with the Berlin Heart EXCOR pediatric ventricular assist device (VAD), the most commonly used VAD in children, and affects 1 in 3 children. We sought to determine whether a modified anti-thrombotic guideline, involving more intense platelet inhibition and less reliance on platelet function testing, is associated with a lower incidence of stroke. METHODS: All children supported with the EXCOR at Stanford from 2009 to 2014 were divided into 2 cohorts based on the primary anti-thrombotic guideline used to prevent pump thrombosis: (1) the Edmonton Anti-thrombotic Guideline (EG) cohort, which included children implanted before September 2012 when dual anti-platelet therapy was used with doses titrated to Thromboelastrography/PlateletMapping (TEG/PM); and (2) the Stanford Modified Anti-thrombotic Guideline (SG) cohort, which included children implanted on or after September 2012 when triple anti-platelet therapy was used routinely and where doses were uptitrated to high, weight-based dosing targets, with low-dose steroids administered as needed for inflammation...
May 20, 2017: Journal of Heart and Lung Transplantation
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