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Journal of Heart and Lung Transplantation

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https://www.readbyqxmd.com/read/30529200/cell-replacement-in-human-lung-bioengineering
#1
Brandon A Guenthart, John D O'Neill, Jinho Kim, Kenmond Fung, Gordana Vunjak-Novakovic, Matthew Bacchetta
BACKGROUND: As the number of patients with end-stage lung disease continues to rise, there is a growing need to increase the limited number of lungs available for transplantation. Unfortunately, attempts at engineering functional lung de novo have been unsuccessful, and artificial mechanical devices have limited utility as a bridge to transplant. This difficulty is largely due to the size and inherent complexity of the lung; however, recent advances in cell-based therapeutics offer a unique opportunity to enhance traditional tissue-engineering approaches with targeted site- and cell-specific strategies...
November 22, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30529199/perils-of-bridge-to-transplantation-in-patients-on-continuous-flow-left-ventricular-assist-devices
#2
EDITORIAL
Nader Moazami, Alex Reyentovich
No abstract text is available yet for this article.
November 22, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30522722/initial-combination-therapy-with-ambrisentan-tadalafil-on-pulmonary-arterial-hypertension%C3%A2-related-hospitalization-in-the-ambition-trial
#3
Jean-Luc Vachiéry, Nazzareno Galiè, Joan Albert Barberá, Adaani E Frost, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Vallerie V McLaughlin, Andrew J Peacock, Gérald Simonneau, Christiana Blair, Karen L Miller, Jonathan Langley, Lewis J Rubin
BACKGROUND: In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. These results were primarily driven by a reduction in PAH-related hospitalization in the combination therapy group, although a significant effect was not observed in a post-hoc analysis of all-cause hospitalization...
November 22, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30503053/outcomes-from-a-recovery-protocol-for-patients-with-continuous-flow-left-ventricular-assist-devices
#4
Jan Knierim, Roland Heck, Marina Pieri, Felix Schoenrath, Sajjad Soltani, Philipp Stawowy, Stephan Dreysse, Julia Stein, Marcus Müller, Johanna Mulzer, Michael Dandel, Volkmar Falk, Thomas Krabatsch, Evgenij Potapov
BACKGROUND: In this retrospective analysis we evaluated a standardized echocardiographic assessment and an invasive technique for patient selection for successful continuous-flow left ventricular assist device (CF-LVAD) explantation. METHODS: Inclusion criteria for LVAD recovery assessment were: clinically stable condition; LVAD support for >6 months; physical activity; normal echocardiography findings; and no more than mild valvular disease and aortic valve opening...
November 15, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30497817/freedom-from-chronic-lung-allograft-dysfunction-clad-or-clad-free-survival-what-s-in-a-name
#5
EDITORIAL
Geert M Verleden, Stijn E Verleden, Robin Vos
No abstract text is available yet for this article.
November 15, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30503074/evaluation-of-flow-modulation-approaches-in-ventricular-assist-devices-using-an-in-vitro-endothelial-cell-culture-model
#6
Thomas A Haglund, Namakkal S Rajasekaran, Benjamin Smood, Guruprasad A Giridharan, Charles W Hoopes, William L Holman, David C Mauchley, Sumanth D Prabhu, Salpy V Pamboukian, Jose A Tallaj, Indranee N Rajapreyar, James K Kirklin, Palaniappan Sethu
BACKGROUND: Continuous-flow ventricular assist devices (CF-VADs) produce non-physiologic flow with diminished pulsatility, which is a major risk factor for development of adverse events, including gastrointestinal (GI) bleeding and arteriovenous malformations (AVMs). Introduction of artificial pulsatility by modulating CF-VAD flow has been suggested as a potential solution. However, the levels of pulsatility and frequency of CF-VAD modulation necessary to prevent adverse events are currently unknown and need to be evaluated...
November 2, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30466803/prognostic-significance-of-early-pulmonary-function-changes-after-onset-of-chronic-lung-allograft-dysfunction
#7
Jamie L Todd, Megan L Neely, C A Finlen Copeland, Courtney W Frankel, John M Reynolds, Scott M Palmer
BACKGROUND: Chronic lung allograft dysfunction (CLAD), including the phenotypes of bronchiolitis obliterans syndrome (BOS) and restrictive CLAD (R-CLAD), represents the leading cause of late death after lung transplantation. Little is known, however, regarding the natural history or prognostic significance of pulmonary function changes after the onset of these conditions. We examined changes in forced expiratory volume in 1 second (FEV1 ) and forced vital capacity (FVC) over the first 18 months after CLAD...
October 31, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30459063/outcomes-of-children-with-congenital-heart-disease-implanted-with-ventricular-assist-devices-an-analysis-of-the-pediatric-interagency-registry-for-mechanical-circulatory-support-pedimacs
#8
David M Peng, Devin A Koehl, Ryan S Cantor, Kristen N McMillan, Aliessa P Barnes, Patrick I McConnell, Jessica Jordan, Nicholas D Andersen, James D St Louis, Katsuhide Maeda, James K Kirklin, Steven J Kindel
BACKGROUND: The reported ventricular assist device (VAD) experience in the pediatric congenital heart disease (CHD) population is limited. We sought to describe contemporary use and outcomes of VADs in children with CHD and compare these outcomes to those of non-CHD children. METHODS: Patients enrolled in the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) between September 19, 2012 through June 30, 2017 were included. CHD was classified as biventricular vs single ventricle (Stages 1, 2, or 3)...
October 31, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30466802/long-term-outcomes-after-transplantation-after-support-with-a-pulsatile-pediatric-ventricular-assist-device
#9
Aamir Jeewa, Michiaki Imamura, Charles Canter, Robert A Niebler, Christina VanderPluym, David N Rosenthal, James K Kirklin, Ryan S Cantor, Margaret Tresler, David Michael McMullan, Victor O Morell, Mark Turrentine, Rebecca Ameduri, Khanh Nguyen, Kirk Kanter, Jennifer Conway, Robert Gajarski, Charles D Fraser
BACKGROUND: There has been increasing use of durable ventricular assist devices (VAD) in children as a bridge to transplantation (BTT). The Berlin Heart investigational device exemption (IDE) trial was the first pediatric VAD trial to demonstrate excellent survival outcomes as a BTT. OBJECTIVES: Our aim was to compare the expanded post-transplant outcomes for children enrolled in the Berlin Heart IDE trial to a matched Pediatric Heart Transplant Study (PHTS) cohort not requiring mechanical circulatory support (MCS)...
October 26, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30454886/pre-transplant-amiodarone-use-and-outcomes-in-children-after-heart-transplantation
#10
LETTER
Ryan J Butts, Anne I Dipchand, David Sutcliffe, Maria Bano, Robert Morrow, Richard Kirk
No abstract text is available yet for this article.
October 25, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30502009/time-dependent-prognostic-effects-of-recipient-and-donor-age-in-adult-heart-transplantation
#11
Henrik Bergenfeldt, Lars H Lund, Josef Stehlik, Bodil Andersson, Peter Höglund, Johan Nilsson
BACKGROUND: Recipient age and donor age are well-known prognostic factors in adult heart transplantation. However, the association between donor age and recipient age and their interaction and short- and long-term mortality is unknown. METHODS: We studied 64,354 heart transplants to adult recipients between 1988 and 2013 in the ISHLT Registry. Donor age and recipient age were analyzed as continuous and categorical variables and restricted cubic spline functions to assess non-linear associations and interactions...
October 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30420303/lung-transplantation-in-a-patient-with-niemann-pick-disease
#12
LETTER
Hannah Mannem, Sarah Kilbourne, Max Weder
No abstract text is available yet for this article.
October 16, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30396846/usefulness-of-a-temporary-endovascular-left-ventricular-assist-system-as-a-bridge-to-facilitate-treatment-of-mediastinitis-associated-with-a-permanent-device
#13
LETTER
Marcus Mueller, Evjenij Potapov, Thomas Krabatsch
No abstract text is available yet for this article.
October 16, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30391199/validation-of-a-post-transplant-chronic-lung-allograft-dysfunction-classification-system
#14
Anke Van Herck, Stijn E Verleden, Annelore Sacreas, Tobias Heigl, Bart M Vanaudenaerde, Lieven J Dupont, Jonas Yserbyt, Eric K Verbeken, Arne P Neyrinck, Dirk Van Raemdonck, Geert M Verleden, Robin Vos
BACKGROUND: Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction (CLAD). Our study evaluated the prevalence and prognostic importance of obstructive and restrictive CLAD phenotypes, with or without an identifiable underlying cause, to validate the recently proposed classification system for CLAD. METHODS: Data for patients who underwent LTx between 2004 and 2015 with a minimal survival of 180 days post-LTx were retrospectively collected...
October 4, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30415828/a-newly-developed-transaortic-axial-flow-ventricular-assist-device-early-clinical-experience
#15
LETTER
Alexander M Bernhardt, Samer Hakmi, Christoph Sinning, Edith Lubos, Hermann Reichenspurner
No abstract text is available yet for this article.
October 2, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30391200/rapid-deployment-of-an-aortic-valve-prosthesis-during-ventricular-assist-device-implantation
#16
LETTER
Shivanand Gangahanamaiah, Silvana F Marasco
No abstract text is available yet for this article.
October 2, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30391195/fontan-associated-protein-losing-enteropathy-and-post%C3%A2-heart-transplant-outcomes-a-multicenter-study
#17
Kurt R Schumacher, SunkyungYu, Ryan Butts, Chesney Castleberry, Sharon Chen, Erik Edens, Justin Godown, Jonathan Johnson, Mariska Kemna, Kimberly Lin, Ray Lowery, Kathleen Simpson, Shawn West, Ivan Wilmot, Jeffrey G Gossett
BACKGROUND: The influence of Fontan-associated protein-losing enteropathy's (PLE) severity, duration, and treatment on heart transplant (HTx) outcomes is unknown. We hypothesized that long-standing PLE and PLE requiring more intensive therapy are associated with increased post-HTx mortality. METHODS: This 12-center, retrospective cohort study of post-Fontan patients with PLE referred for HTx from 2003 to 2015 involved collection of demographic, medical, surgical, and catheterization data, as well as PLE-specific data, including duration of disease, intensity/details of treatment, hospitalizations, and complications...
October 2, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30391201/assessment-of-lung-edema-during-ex-vivo-lung-perfusion-by-single-transpulmonary-thermodilution-a-preliminary-study-in-humans
#18
Grégoire Trebbia, Edourd Sage, Morgan Le Guen, Antoine Roux, Alexis Soummer, Philippe Puyo, François Parquin, Marc Stern, Tai Pham, Samir G Sakka, Charles Cerf
BACKGROUND: Single transpulmonary thermodilution (SD) with extravascular lung water index (EVLWI) could become a new tool to better assess lung graft edema during ex-vivo lung perfusion (EVLP). In this study we compare EVLWI with conventional methods to better select lungs during EVLP and to predict post-transplant primary graft dysfunction (PGD). METHODS: We measured EVLWI, arterial oxygen/fraction of inspired oxygen (P/F) ratio, and static lung compliance (SLC) during EVLP in an observational study...
October 1, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30459062/donor-organ-turn-downs-and-outcomes-after-listing-for-pediatric-heart-transplant
#19
Ryan R Davies, Maria Bano, Ryan J Butts, Robert D B Jaquiss, Richard Kirk
BACKGROUND: Pediatric heart transplant waitlist mortality remains significant but allograft offer refusals are common and allografts continue to be discarded. Our aim in this study was to assess the impact of donor organ refusals on mortality after listing using a multi-institutional data set. METHODS: In this study we conducted a retrospective review of donor offers made to pediatric (<18 years) recipients in the United States in the period from 2007 to 2017...
September 28, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/30391192/mitochondrial-transplantation-prolongs-cold-ischemia-time-in-murine-heart-transplantation
#20
Kamila Moskowitzova, Borami Shin, Kaifeng Liu, Giovanna Ramirez-Barbieri, Alvise Guariento, David Blitzer, Jerusha K Thedsanamoorthy, Rouan Yao, Erin R Snay, James A H Inkster, Arzoo Orfany, David Zurakowski, Douglas B Cowan, Alan B Packard, Gary A Visner, Pedro J Del Nido, James D McCully
BACKGROUND: Cold ischemia time (CIT) causes ischemia‒reperfusion injury to the mitochondria and detrimentally effects myocardial function and tissue viability. Mitochondrial transplantation replaces damaged mitochondria and enhances myocardial function and tissue viability. Herein we investigated the efficacy of mitochondrial transplantation in enhancing graft function and viability after prolonged CIT. METHODS: Heterotopic heart transplantation was performed in C57BL/6J mice...
September 28, 2018: Journal of Heart and Lung Transplantation
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