journal
MENU ▼
Read by QxMD icon Read
search

Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

journal
https://www.readbyqxmd.com/read/28541397/prevalence-and-co-occurrence-of-geriatric-syndromes-in-people-aged-75-years-and-older-in-france-results-from-the-bordeaux-three-city-study
#1
Maturin Tabue-Teguo, Leslie Grasset, José Alberto Avila-Funes, Robin Genuer, Cecile Proust-Lima, Karine Péres, Catherine Féart, Hélène Amieva, Magali González-Colaço Harmand, Catherine Helmer, Nathalie Salles, Muriel Rainfray, Jean François Dartigues
Background: Geriatric syndromes (GSs) are often the result of cumulative insults to multiple organ systems and are considered common in older adults. However, their frequency and co-occurrence are not well known in the elderly population. This study aimed to determine the prevalence of several GSs and to analyze the co-occurrence of these syndromes in a general population of elderly individuals. Methods: A cross-sectional analysis of 630 adults aged 75 years or older participating in the 10-year follow-up of the Bordeaux sample of the French Three-City Study was conducted...
May 24, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28541396/prospective-disability-in-different-combinations-of-somatic-and-mental-multimorbidity
#2
Ana R Quiñones, Sheila Markwardt, Stephen Thielke, Ola Rostant, Elizabeth Vásquez, Anda Botoseneanu
BACKGROUND.: Multimorbidity (multiple co-occurring chronic conditions) may be an important contributor to disability and poor health-related quality of life. The functional consequences of specific combinations of somatic and mental health conditions are unclear. METHODS.: Nationally-representative prospective cohort study using the National Health and Aging Trends Study data of Medicare beneficiaries. We included 4,017 participants aged 65 years or older interviewed in 2013 and 2014...
May 24, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28535277/sensory-impairments-and-cognitive-function-in-middle-aged-adults
#3
Carla R Schubert, Karen J Cruickshanks, Mary E Fischer, Yanjun Chen, Barbara E K Klein, Ronald Klein, A Alex Pinto
Background: Hearing, visual, and olfactory impairments have been associated with cognitive impairment in older adults but less is known about associations with cognitive function in middle-aged adults. Methods: Sensory and cognitive functions were measured on participants in the baseline examination (2005-2008) of the Beaver Dam Offspring Study. Cognitive function was measured with the Trail Making tests A (TMTA) and B (TMTB) and the Grooved Peg Board test. Pure-tone audiometry, Pelli-Robson letter charts, and the San Diego Odor Identification test were used to measure hearing, contrast sensitivity, and olfaction, respectively...
May 23, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28531280/effects-of-calorie-restriction-and-fiber-type-on-glucose-uptake-and-abundance-of-electron-transport-chain-and-oxidative-phosphorylation-proteins-in-single-fibers-from-old-rats
#4
Haiyan Wang, Edward B Arias, Carmen S Yu, Anthony R P Verkerke, Gregory D Cartee
Calorie restriction (CR; reducing calorie intake by ~40% below ad libitum) can increase glucose uptake by insulin-stimulated muscle. Because skeletal muscle is comprised of multiple, heterogeneous fiber types, our primary aim was to determine in 23-26 months-old rats the effects of CR (initiated at 14 weeks-old) and fiber type on insulin-stimulated glucose uptake by single fibers of diverse fiber types. Isolated epitrochlearis muscles from AL and CR rats were incubated with [3H]-2-deoxyglucose ±insulin. Glucose uptake and fiber type were determined for single fibers dissected from the muscles...
May 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28531269/change-in-the-rate-of-biological-aging-in-response-to-caloric-restriction-calerie-biobank-analysis
#5
Daniel W Belsky, Kim M Huffman, Carl F Pieper, Idan Shalev, William E Kraus
Biological aging measures have been proposed as proxies for extension of healthy lifespan in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise; but it is not known if these methods are sensitive to changes caused by geroprotective therapy. We conducted analysis of two proposed methods to quantify biological aging using data from a recently concluded trial of an established geroprotector, caloric restriction. We obtained data from the National Institute on Aging CALERIE randomized trial through its public-access biobank (https://calerie...
May 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28531256/advances-in-preclinical-models-of-frailty
#6
Alice E Kane, Susan E Howlett
No abstract text is available yet for this article.
May 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28525611/adverse-childhood-experiences-and-higher-level-functional-limitations-among-older-japanese-people-results-from-the-jages-study
#7
Airi Amemiya, Takeo Fujiwara, Hiroshi Murayama, Yukako Tani, Katsunori Kondo
Background.: A life-course perspective is essential in understanding the determinants of higher-level functional limitations. We examine the impact of adverse childhood experiences (ACEs) on higher-level functional limitations in older people. Methods.: Data were from the Japan Gerontological Evaluation Study 2013, a population-based cohort of independent people aged 65 years or older across Japan (n = 19,220). ACEs before the age of 18 were assessed in terms of seven adversities: parental death, parental divorce, parental mental illness, family violence, physical abuse, psychological neglect, and psychological abuse...
May 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28525586/prevalence-and-correlates-of-frailty-among-community-dwelling-chinese-older-adults-the-china-health-and-retirement-longitudinal-study
#8
Chenkai Wu, Ellen Smit, Qian-Li Xue, Michelle C Odden
Background.: Frailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes. Although there is preponderance of literature on frailty in developed countries, limited investigations have been conducted in less developed regions including China-a country that has the world's largest aging population. We examined frailty prevalence in China by socio-demographics and geographic region, and investigated correlates of frailty...
May 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28525535/sexual-dimorphism-and-aging-differentially-regulate-adaptive-homeostasis
#9
Laura C D Pomatto, John Tower, Kelvin J A Davies
External and internal stimuli cause modifications to gene and biochemical pathways. In turn, demonstrating that biological systems continuously make short-term adaptations both to set-points, and to the range of "normal" capacity, due to mild conditional changes, or to subtoxic, nondamaging levels of chemical agents. This is termed as "Adaptive Homeostasis," defined with the following: "The transient expansion or contraction of the homeostatic range in response to exposure to sub-toxic, nondamaging, signaling molecules or events, or the removal or cessation of such molecules or events...
May 18, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28510637/telomeres-nutrition-and-longevity-can-we-really-navigate-our-aging
#10
Nikolina Škrobot Vidacek, Lucia Nanic, Sanda Ravlic, Mary Sopta, Marko Geric, Goran Gajski, Vera Garaj-Vrhovac, Ivica Rubelj
Telomeres are dynamic chromosome-end structures that serve as guardians of genome stability. They are known to be one of the major determinants of aging and longevity in higher mammals. Studies have demonstrated a direct correlation between telomere length and life expectancy, stress, DNA damage, and onset of aging-related diseases. This review discusses the most important factors that influence our telomeres. Various genetic and environmental factors such as diet, physical activity, obesity, and stress are known to influence health and longevity as well as telomere dynamics...
May 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28510636/impact-of-aging-on-calcium-signaling-and-membrane-potential-in-endothelium-of-resistance-arteries-a-role-for-mitochondria
#11
Erik J Behringer, Steven S Segal
Impaired blood flow to peripheral tissues during advanced age is associated with endothelial dysfunction and diminished bioavailability of nitric oxide (NO). However, it is unknown whether aging impacts coupling between intracellular calcium ([Ca2+]i) signaling and small- and intermediate K+ channel (SKCa/IKCa) activity during endothelium-derived hyperpolarization (EDH), a signaling pathway integral to dilation of the resistance vasculature. To address the potential impact of aging on EDH, Fura-2 photometry and intracellular recording were applied to evaluate [Ca2+]i and membrane potential of intact endothelial tubes (width, 60 µm; length, 1-3 mm) freshly isolated from superior epigastric arteries of young (4-6 mo) and old (24-26 mo) male C57BL/6 mice...
May 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28510619/diabetes-and-cognitive-decline-in-older-adults-the-ginkgo-evaluation-of-memory-study
#12
Priya Palta, Michelle C Carlson, Rosa M Crum, Elizabeth Colantuoni, A Richey Sharrett, Sevil Yasar, Richard L Nahin, Steven T DeKosky, Beth Snitz, Oscar Lopez, Jeff D Williamson, Curt D Furberg, Stephen R Rapp, Sherita Hill Golden
Background: Previous studies have shown that individuals with diabetes exhibit accelerated cognitive decline. However, methodological limitations have limited the quality of this evidence. Heterogeneity in study design, cognitive test administration, and methods of analysis of cognitive data have made it difficult to synthesize and translate findings to practice. We analyzed longitudinal data from the Ginkgo Evaluation of Memory Study to test our hypothesis that older adults with diabetes have greater test-specific and domain-specific cognitive declines compared to older adults without diabetes...
May 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28505291/comparison-of-the-simplified-swhi-and-the-standard-chs-frailty-phenotypes-for-prediction-of-mortality-incident-falls-and-hip-fractures-in-older-women
#13
Oleg Zaslavsky, Shira Zelber-Sagi, Andrea Z LaCroix, Robert L Brunner, Robert B Wallace, Barbara B Cochrane, Nancy F Woods
Background: We compared the simplified Women's Health Initiative (sWHI) and the standard Cardiovascular Health Study (CHS) frailty phenotypes in predicting falls, hip fracture, and death in older women. Methods: Participants are from the WHI Clinical Trial. CHS frailty criteria included weight loss, exhaustion, weakness, slowness, and low physical activity. The sWHI frailty score used two items from the RAND-36 physical function and vitality subscales, one item from the WHI physical activity scale plus the CHS weight loss criteria...
May 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28505228/associations-of-musculoskeletal-pain-with-mobility-in-older-adults-potential-cerebral-mechanisms
#14
Yenisel Cruz-Almeida, Andrea Rosso, Zachary Marcum, Tamara Harris, Anne B Newman, Michael Nevitt, Suzanne Satterfield, Kristine Yaffe, Caterina Rosano
Background: Musculoskeletal pain is highly prevalent and limits mobility in older adults. A potential mechanism by which pain affects mobility could be through its negative impact on the brain. We examined whether structural integrity of cerebral gray and white matter (WM) mediated the relationship between pain and mobility in community-dwelling older adults. Methods: Musculoskeletal pain, gait speed, and neuroimaging data were obtained concurrently from the Health ABC study (mean age = 83/56% female, n = 212)...
May 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28505227/resveratrol-enhances-exercise-induced-cellular-and-functional-adaptations-of-skeletal-muscle-in-older-men-and-women
#15
Stephen E Alway, Jean L McCrory, Kalen Kearcher, Austen Vickers, Benjamin Frear, Diana L Gilleland, Daniel E Bonner, James M Thomas, David A Donley, Mathew W Lively, Junaith S Mohamed
Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took either a placebo or resveratrol (500 mg/d) to test the hypothesis that resveratrol treatment combined with exercise would increase mitochondrial density, muscle fatigue resistance and cardiovascular function more than exercise alone. Contrary to our hypothesis, aerobic and resistance exercise coupled with resveratrol treatment did not reduce cardiovascular risk further than exercise alone. However, exercise added to resveratrol treatment improved the indices of mitochondrial density, and muscle fatigue resistance more than placebo and exercise treatments...
May 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28498918/expression-and-activity-of-the-small-rhogtpase-cdc42-in-blood-cells-of-older-adults-are-associated-with-age-and-cardiovascular-disease
#16
M Carolina Florian, Jochen Klenk, Gina Marka, Karin Soller, Hady Kiryakos, Richard Peter, Florian Herbolsheimer, Dietrich Rothenbacher, Michael Denkinger, Hartmut Geiger
The small RhoGTPase Cdc42 is mechanistically linked to aging of multiple tissues and to rejuvenation of hematopoietic stem cells (HSCs) in mice. However, data validating Cdc42 activity and expression as biomarker for aging in humans are still missing. Here we hypothesized that Cdc42 might serve as a novel biomarker of aging in older adults and therefore we determined Cdc42 activity and expression levels in peripheral blood (PB) cells from a cohort of 196 donors. We investigated the association of these parameters with both chronological and biological aging...
May 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28498894/the-intersection-of-aging-biology-and-the-pathobiology-of-lung-diseases-a-joint-nhlbi-nia-workshop
#17
Gr Scott Budinger, Ronald A Kohanski, Weiniu Gan, Michael S Kobor, Luis A Amaral, Mary Armanios, Karl T Kelsey, Annie Pardo, Rubin Tuder, Fernando Macian, Navdeep Chandel, Douglas Vaughan, Mauricio Rojas, Ana L Mora, Elizabeth Kovacs, Steven R Duncan, Toren Finkel, Augustine Choi, Oliver Eickelberg, Danica Chen, Alvar Agusti, Moises Selman, William E Balch, Paula Busse, Anning Lin, Richard Morimoto, Jacob I Sznajder, Victor J Thannickal
Death from chronic lung disease is increasing and Chronic Obstructive Pulmonary Disease has become the third leading cause of death in the United States in the past decade. Both chronic and acute lung diseases disproportionately affect elderly individuals, making it likely that these diseases will become more frequent and severe as the worldwide population ages. Chronic lung diseases are associated with substantial morbidity, frequently resulting in exercise limiting dyspnea, immobilization and isolation. Therefore, effective strategies to prevent or treat lung disease are likely to increase healthspan as well as lifespan...
May 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28498887/sex-differences-in-risk-for-alzheimer-s-disease-related-to-neurotrophin-gene-polymorphisms-the-cache-county-memory-study
#18
Joshua Matyi, JoAnn T Tschanz, Gail B Rattinger, Chelsea Sanders, E K Vernon, Chris Corcoran, John S K Kauwe, Mona Buhusi
Neurotrophins, including nerve-growth factor (NGF) and brain-derived neurotrophic factor (BDNF), have been implicated in Alzheimer's disease (AD). Associations between AD and neurotrophin signaling genes have been inconsistent, with few studies examining sex differences in risk. We examined four single-nucleotide polymorphisms (SNPs) involved in neurotrophin signaling (rs6265, rs56164415, rs2289656, rs2072446) and risk for AD by sex in a population-based sample of older adults. 3499 individuals without dementia at baseline [Mean (SD) age = 74...
May 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28498937/the-prevalence-of-anosmia-and-associated-factors-among-u-s-black-and-white-older-adults
#19
Jing Dong, Jayant M Pinto, Xuguang Guo, Alvaro Alonso, Gregory Tranah, Jane A Cauley, Melissa Garcia, Suzanne Satterfield, Xuemei Huang, Tamara Harris, Thomas H Mosley, Honglei Chen
Background: Olfactory impairment is common among older adults; however, data are largely limited to whites. Methods: We conducted pooled analyses of two community-based studies: the Atherosclerosis Risk in Communities study (ARIC, 1,398 blacks and 4,665 whites), and the Health, Aging, and Body Composition study (Health ABC, 958 blacks and 1,536 whites) to determine the prevalence of anosmia and associated factors for black and white older adults in the United States...
May 11, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28486590/activation-induced-autophagy-is-preserved-in-cd4-t-cells-in-familial-longevity
#20
Yotam Raz, Ignacio Guerrero-Ros, Andrea Maier, P Eline Slagboom, Gil Atzmon, Nir Barzilai, Fernando Macian
As with many other tissues and organs, the immune system is also affected by age. Immunosenescence is characterized by a decreased ability of immune cells to mount a productive response upon exposure to new antigens. Several studies have reported that members of families with exceptional longevity show improved immune function, which might contribute to the increased life- and health-span observed in those families. Autophagy is a catabolic process that delivers cytoplasmic material to the lysosomes for degradation...
May 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
journal
journal
20151
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"