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Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

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https://www.readbyqxmd.com/read/29452335/change-in-cardiometabolic-risk-among-blacks-whites-and-hispanics-findings-from-the-health-and-retirement-study
#1
Uchechi A Mitchell, Jennifer A Ailshire, Eileen M Crimmins
Background: Blacks experience greater multi-system physiological dysregulation, or cumulative biological risk, which is associated with poor cardiometabolic health and mortality. In this study, we assess race differences in change in risk over four years among older whites, blacks and Hispanics. Method: We examined race differences in 4-year change in individual biomarkers and a cumulative measure of risk-cardiometabolic risk (CMR)-using data for each respondent from two waves of the Health and Retirement Study's biomarker assessment (n=5,512)...
February 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29438556/physical-performance-trajectories-and-mortality-among-older-mexican-americans
#2
Miriam Mutambudzi, Nai-Wei Chen, Bret Howrey, Marc A Garcia, Kyriakos S Markides
Background: We sought to identify distinct trajectory classes of physical performance in Mexican Americans aged 75 years and older, and to examine whether these trajectories predict mortality. Methods: We used 4 waves of Hispanic Established Populations for Epidemiologic Studies of the Elderly (H-EPESE) data for adults 75 years and older from 2004-5 to 2013. Latent growth curve analysis was used to identify distinct trajectory classes. Multinomial logistic regression analysis was used to examine the association between baseline characteristics and the newly constructed trajectories...
February 9, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29438496/the-adiponectin-paradox-in-the-elderly-associations-with-body-composition-physical-functioning-and-mortality
#3
Joshua F Baker, Anne B Newman, Alka Kanaya, Mary B Leonard, Babette Zemel, Iva Miljkovic, Jin Long, David Weber, Tamara B Harris
Background: To determine if adiponectin levels are associated with weight loss, low muscle mass, and physical functioning among the elderly and to determine independent associations with incident disability and death. Methods: Included were 3,044 participants from the Health, Aging and Body Composition Study who had whole-body dual energy absorptiometry performed to evaluate appendicular lean mass index (ALMI, kg/m2) and fat mass index (FMI, kg/m2), CT measures of thigh muscle density, weight histories, estimates of physical functioning, and adiponectin levels at enrollment...
February 9, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29432613/circulating-dkk1-and-trail-are-associated-with-cognitive-decline-in-community-dwelling-older-adults-with-cognitive-concerns
#4
Ryan D Ross, Raj C Shah, Sue Leurgans, Teodoro Bottligieri, Robert S Wilson, D Rick Sumner
Background: Osteoporosis and Alzheimer's disease (AD) are common diseases of aging that would seem to be unrelated, but may be linked through the influence of bone-derived signals on brain function. The current study aimed to investigate the relationship between circulating levels of bone-related biomarkers and cognition. Methods: The population included 103 community-dwelling older individuals with memory concerns but without cognitive impairment. A global cognition summary measure was collected at baseline and 6, 12, and 18-months post-enrollment by converting raw scores from 19 cognitive function tests to z-scores and averaging...
February 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29432609/impaired-cerebral-hemodynamics-and-frailty-in-patients-with-cardiovascular-disease
#5
Miri Lutski, Salo Haratz, Galit Weinstein, Uri Goldbourt, David Tanne
Background: Recent studies suggest that impaired cerebrovascular reactivity (CVR), a marker of cerebral microvascular damage, is associated with a higher risk of stroke, cognitive decline and mortality. We tested whether abnormal cerebrovascular status is associated with late-life frailty among men with pre-existing cardiovascular disease. Methods: A subset of 327 men (mean age at baseline 56.7±6.5 years) who previously participated in the Bezafibrate Infarction Prevention (BIP) trial (1990-1997) and then in the BIP Neurocognitive study underwent a neurovascular evaluation 14...
February 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29420687/intermittent-mtor-inhibition-reverses-kidney-aging-in-old-rats
#6
Andrea Di Francesco, Alberto Diaz-Ruiz, Rafael de Cabo, Michel Bernier
No abstract text is available yet for this article.
February 6, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415201/genetic-variation-in-foxo3-is-associated-with-self-rated-health-in-a-population-based-sample-of-older-individuals
#7
Anna Zettergren, Silke Kern, Lina Rydén, Svante Östling, Kaj Blennow, Henrik Zetterberg, Hanna Falk, Ingmar Skoog
Self-rated health (SRH) strongly predicts mortality. Twin studies estimate that genetic factors account for a substantial part of the variability in SRH. Variations in the gene FOXO3 (forkhead box O3), and in genes located at the APOE (apoplipoprotein E) locus, are associated with longevity. This study explores the relationship between SRH and genetic variation related to longevity, in a population-based cohort of older individuals. SRH was assessed among 1520 individuals aged 75 to 87, and five single nucleotide polymorphisms (SNPs), in APOE, TOMM40 (translocase of outer mitochondrial membrane 40 homolog), and FOXO3 were genotyped...
February 5, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415134/induction-of-a-senescence-like-phenotype-in-cultured-human-fetal-microglia-during-hiv-1-infection
#8
Natalie C Chen, Andrea T Partridge, Ferit Tuzer, Justin Cohen, Timothy Nacarelli, Sonia Navas-Martín, Christian Sell, Claudio Torres, Julio Martín-García
HIV-1 causes premature aging in chronically-infected patients. Despite effective anti-retroviral therapy, around 50% of patients suffer HIV-associated neurocognitive disorders (HAND), which likely potentiate aging-associated neurocognitive decline. Microglia support productive HIV-1 infection in the brain. Elevated markers of cellular senescence, including p53 and p21, have been detected in brain tissues from patients with HAND, but the potential for microglia senescence during HIV-1 infection has not been investigated...
February 5, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415276/apathy-is-associated-with-greater-decline-in-subjective-but-not-in-objective-measures-of-physical-functioning-in-older-people-without-dementia
#9
Marieke Jantien Henstra, Thomas Christiaan Feenstra, Nathalie van der Velde, Roos C van der Mast, Hannie Comijs, Max L Stek, Didi Rhebergen
Background: In older people, both apathy and depression (which frequently co-occurs with apathy) have been associated with poor physical functioning, a major health concern. We investigated the association between apathy and physical functioning in older people without dementia and whether this association is modified by depression. Methods: We used the data from 380 older participants (with and without depression) taking part in the Netherlands Study of Depression in Older Persons, with baseline scores on the Apathy Scale and baseline and 2-year follow-up scores on at least one measure of physical functioning...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415265/oxidation-products-of-5-methyl-cytosine-are-decreased-in-senescent-cells-and-tissues-of-progeroid-mice
#10
Ewelina Zarakowska, Jolanta Czerwinska, Agnieszka Tupalska, Matt J Yousefzadeh, Siobhán Q Gregg, Claudette M St Croix, Laura J Niedernhofer, Marek Foksinski, Daniel Gackowski, Anna Szpila, Marta Starczak, Barbara Tudek, Ryszard Olinski
5-Hydroxymethylcytosine and 5-formylcytosine are stable DNA base modifications generated from 5-methylcytosine by the ten-eleven translocation protein family that function as epigenetic markers. 5-Hydroxymethyluracil may also be generated from thymine by ten-eleven translocation enzymes. Here, we asked if these epigenetic changes accumulate in senescent cells, since they are thought to be inversely correlated with proliferation. Testing this in ERCC1-XPF-deficient cells and mice also enabled discovery if these DNA base changes are repaired by nucleotide excision repair...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415252/effects-of-different-dietary-protocols-on-general-activity-and-frailty-of-male-wistar-rats-during-aging
#11
Smilja Todorovic, Kosara Smiljanic, Sabera Ruzdijic, Aleksandra Mladenovic Djordjevic, Selma Kanazir
Dietary restriction (DR) is an important experimental paradigm for lifespan and healthspan extension, but its specific contribution regarding the type, onset and duration are still debatable. This study was designed to examine the impact of different dietary protocols by assessing the behavioral changes during aging. We exposed male Wistar rats of various age to ad libitum (AL) or DR (60% of AL daily intake) feeding regimens with different onsets. The impact of DR on locomotor activity, memory and learning was examined in 12-, 18- and 24-month-old treated animals and controls using open field (OF) and Y maze tests...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415200/sleep-duration-and-sleep-disturbances-as-predictors-of-healthy-and-chronic-disease-free-life-expectancy-between-ages-50-and-75-a-pooled-analysis-of-three-cohorts
#12
Sari Stenholm, Jenny Head, Mika Kivimäki, Linda L Magnusson Hanson, Jaana Pentti, Naja H Rod, Alice J Clark, Tuula Oksanen, Hugo Westerlund, Jussi Vahtera
Background: The aim of this study was to examine the associations of sleep duration and sleep disturbances with healthy and chronic disease-free life expectancy (LE) between ages 50 and 75. Methods: Data were drawn from repeated waves of three occupational cohort studies in England, Finland and Sweden (n=55,494) and the follow-up ranged from 6 to 18 years. Self-reported sleep duration was categorized into <7h, 7-8.5h and ≥9h and sleep disturbances into no, moderate, and severe...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415197/lncrna-ensmust00000134285-increases-mapk11-activity-regulating-aging-related-myocardial-apoptosis
#13
Xiao Chun Yang, Dong Hui Zhao, Wayne Bond Lau, Ke Qiang Liu, Jia Yu Tian, Zi Chao Cheng, Xin Liang Ma, Jing Hua Liu, Qian Fan
Previous studies have demonstrated aging promotes myocardial apoptosis after ischemia/reperfusion, via unknown specific mechanisms. The present study investigates the potential relationship between lncRNAs and aging-related apoptosis by lncRNA/mRNA microarray technology. The results indicate aging increased myocardial lncRNA ENSMUST00000134285 and mMAPK11, confirmed by both bioinformatics analysis and PCR. Mouse cardiomyocytes were subjected to gene manipulation (ENSMUST00000134285 knockdown and overexpression)...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415184/nlrp3-gene-expression-in-circulating-leukocytes-declines-during-healthy-aging
#14
Jean-Louis Connat, Adélie Dumont, Mickaël Rialland, Bruno Faivre, Gabriele Sorci
Aging is often associated with elevated levels of low grade inflammation supposed to drive age-associated diseases. Here, we conducted a cross-sectional study on 58 healthy volunteers, aged from 19 to 81, to investigate the relationship between age and the expression of three inflammasome component genes (Nlrp3, Asc, Casp1), the up-stream transcription factor NFkB, and the pro-inflammatory cytokine Il-1 in leukocytes. We also assessed C-reactive protein (CRP) and IL-1 in plasma, as additional inflammatory markers...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29415117/attenuated-macrophage-infiltration-in-glomeruli-of-aged-mice-resulting-in-ameliorated-kidney-injury-in-nephrotoxic-serum-nephritis
#15
Yoshikatsu Kaneko, Takamasa Cho, Yuya Sato, Kei Goto, Suguru Yamamoto, Shin Goto, Michael P Madaio, Ichiei Narita
Senescent cells have deleterious effects on the tissue microenvironment through proinflammatory senescence-associated secretory phenotypes; meanwhile, the onset of glomerulonephritis is predominant in younger adults. To clarify the influence of aging on the onset and development of glomerulonephritis, we used a murine model of antibody-mediated nephritis. Sheep nephrotoxic serum was administered in C57BL/6J mice at 12 weeks (adult) or 18 months old (aged) after pre-immunization with sheep IgG. Depositions of sheep IgG and autologous mouse IgG along the glomerular basement membrane and the serum titer of anti-sheep IgG-specific mouse IgG were similar between adult and aged mice...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29408975/sitting-time-and-physical-function-in-australian-retirees-an-analysis-of-bidirectional-relationships
#16
Paul A Gardiner, Natasha Reid, Klaus Gebel, Ding Ding
Background: There is limited evidence on the directionality of the associations of sitting time with physical function. This study examined the longitudinal associations of sitting time with changes in physical function, and physical function with changes in sitting time. Methos: Data from 10,027 retirees in the Social, Economic, and Environmental Factor (SEEF) population-based cohort were collected in 2006-08 and in 2010-11. Daily sitting time was assessed by a single item question...
February 2, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29408961/evidence-for-the-domains-supporting-the-construct-of-intrinsic-capacity
#17
Matteo Cesari, Islene Araujo de Carvalho, Jotheeswaran Amuthavalli Thiyagarajan, Cyrus Cooper, Finbarr C Martin, Jean-Yves Reginster, Bruno Vellas, John R Beard
Healthy ageing can be defined as "the process of developing and maintaining the functional ability that enables wellbeing in older age". Functional ability (i.e., the health-related attributes that enable people to be and to do what they have reason to value) is determined by intrinsic capacity (i.e., the composite of all the physical and mental capacities of an individual), the environment (i.e., all the factors in the extrinsic world that form the context of an individual's life), and the interactions between the two...
February 2, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29408957/disability-prior-to-death-among-the-oldest-old-in-china
#18
Zuyun Liu, Ling Han, Xiaofeng Wang, Qiushi Feng, Thomas M Gill
Background: To estimate the prevalence of disability during the last three years prior to death among the oldest-old (≥80 years) in China. Methods: We used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a nationally representative study of the oldest-old in China. The analytic sample included 23,934 decedents who died between 1998 and 2014 and had at least one interview within the last three years of life. Disability was defined as being incontinent or needing assistance in performing one or more of five other essential activities (bathing, transferring, dressing, eating, and toileting)...
February 2, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29360938/long-term-persistent-organic-pollutants-exposure-induced-telomere-dysfunction-and-senescence-associated-secretary-phenotype
#19
Jinghua Yuan, Yang Liu, Juan Wang, Yuxia Zhao, Keqiu Li, Yaqing Jing, Xiaoning Zhang, Qiang Liu, Xin Geng, Guang Li, Feng Wang
Environmentally persistent organic pollutant (POPs) is the general term for refractory organic compounds that show long-range atmospheric transport, environmental persistence, and bioaccumulation. It has been reported that the accumulation of POPs could lead to cellular DNA damage and adverse effects of on metabolic health. To better understand the mechanism of the health risks associated with POPs, we conducted an evidence based cohort investigation (n=5955) at the Jinghai e-waste disposal center in China from 2009-2016, where people endure serious POPs exposure...
January 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29360935/a-systematic-review-and-meta-analysis-of-the-factors-associated-with-nonadherence-and-discontinuation-of-statins-among-people-aged-%C3%A2-65-years
#20
Richard Ofori-Asenso, Avtar Jakhu, Andrea J Curtis, Ella Zomer, Manoj Gambhir, Maarit Jaana Korhonen, Mark Nelson, Andrew Tonkin, Danny Liew, Sophia Zoungas
Background: Older individuals (aged ≥65 years) are commonly prescribed statins but may experience a range of barriers in adhering to therapy. The factors associated with poor statin adherence and/or discontinuation among this population have not been comprehensively reviewed. Methods: We conducted a systematic review to identify English articles published through December 12, 2016 that reported factors associated with nonadherence and/or discontinuation of statins among older persons...
January 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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