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Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

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https://www.readbyqxmd.com/read/28207064/life-span-extension-with-reduced-somatotrophic-signaling-moderation-of-aging-effect-by-signal-type-sex-and-experimental-cohort
#1
Michael Garratt, Shinichi Nakagawa, Mirre J P Simons
No abstract text is available yet for this article.
February 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28207042/low-lean-mass-with-and-without-obesity-and-mortality-results-from-the-1999-2004-national-health-and-nutrition-examination-survey
#2
John A Batsis, Todd A Mackenzie, Rebecca T Emeny, Francisco Lopez-Jimenez, Stephen J Bartels
No abstract text is available yet for this article.
February 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28184412/cardiovascular-health-is-associated-with-physical-function-among-older-community-dwelling-men-and-women
#3
Yichen Jin, Toshiko Tanaka, Yan Ma, Stefania Bandinelli, Luigi Ferrucci, Sameera A Talegawkar
No abstract text is available yet for this article.
February 10, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28180239/preoperative-serum-metabolites-are-associated-with-postoperative-delirium-in-elderly-hip-fracture-patients
#4
Yong Guo, Yinan Zhang, Peiyu Jia, Wenying Wang, Quanhong Zhou, Lulu Sun, Aihua Zhao, Xin Zhang, Xuemin Wang, Yingchuan Li, Junfeng Zhang, Wei Jiang
No abstract text is available yet for this article.
February 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28177065/gait-speed-and-grip-strength-reflect-cognitive-impairment-and-are-modestly-related-to-incident-cognitive-decline-in-memory-clinic-patients-with-subjective-cognitive-decline-and-mild-cognitive-impairment-findings-from-the-4c-study
#5
Astrid M Hooghiemstra, Inez H G B Ramakers, Nicole Sistermans, Yolande A L Pijnenburg, Pauline Aalten, Renske E G Hamel, René J F Melis, Frans R J Verhey, Marcel G M Olde Rikkert, Philip Scheltens, Wiesje M van der Flier
No abstract text is available yet for this article.
February 8, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28158467/daily-patterns-of-accelerometer-activity-predict-changes-in-sleep-cognition-and-mortality-in-older-men
#6
Jamie M Zeitzer, Terri Blackwell, Andrew R Hoffman, Steve Cummings, Sonia Ancoli-Israel, Katie Stone
No abstract text is available yet for this article.
February 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28158648/development-of-a-rat-clinical-frailty-index
#7
Amy Yorke, Alice E Kane, Camille L Hancock Friesen, Susan E Howlett, Stacy O'Blenes
No abstract text is available yet for this article.
February 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28158621/calorie-restriction-induced-weight-loss-and-exercise-have-differential-effects-on-skeletal-muscle-mitochondria-despite-similar-effects-on-insulin-sensitivity
#8
Elizaveta V Menshikova, Vladimir B Ritov, John J Dube, Francesca Amati, Maja Stefanovic-Racic, Frederico G S Toledo, Paul M Coen, Bret H Goodpaster
No abstract text is available yet for this article.
February 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28158486/screening-for-frailty-in-older-patients-with-early-stage-solid-tumors-a-prospective-longitudinal-evaluation-of-three-different-geriatric-tools
#9
Laura Biganzoli, Anna Rachelle Mislang, Samantha Di Donato, Dimitri Becheri, Chiara Biagioni, Stefania Vitale, Giuseppina Sanna, Elena Zafarana, Stefano Gabellini, Francesca Del Monte, Elena Mori, Daniele Pozzessere, Antonella Brunello, Andrea Luciani, Letizia Laera, Luca Boni, Angelo Di Leo, Giuseppe Mottino
No abstract text is available yet for this article.
February 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28158466/assessing-health-span-in-caenorhabditis-elegans-lessons-from-short-lived-mutants
#10
Jarod A Rollins, Amber C Howard, Sarah K Dobbins, Elsie H Washburn, Aric N Rogers
No abstract text is available yet for this article.
February 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28158434/caenorhabditis-elegans-genes-affecting-interindividual-variation-in-life-span-biomarker-gene-expression
#11
Alexander Mendenhall, Matthew M Crane, Patricia M Tedesco, Thomas E Johnson, Roger Brent
No abstract text is available yet for this article.
February 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28064148/community-weight-loss-to-combat-obesity-and-disability-in-at-risk-older-adults
#12
W Jack Rejeski, Walter T Ambrosius, Jonathan H Burdette, Michael P Walkup, Anthony P Marsh
BACKGROUND: Among older, overweight, and obese adults with either cardiovascular disease or the metabolic syndrome, reduced mobility and loss of leg strength are important risk factors for morbidity, disability, and mortality. It is unclear whether community-based approaches to weight loss may be an effective solution to this public health challenge. METHODS: An 18-month three-site, randomized controlled trial conducted by YMCA staff, with blinded assessors, enrolled 249 older, overweight, and obese adults with either cardiovascular disease or metabolic syndrome with randomization to three interventions: weight loss alone (WL), weight loss + aerobic training (WL + AT), and weight loss + resistance training (WT + RT)...
January 6, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28057695/cancer-and-cognitive-function-the-path-through-life-project
#13
Sarang Kim, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: A limited number of studies have shown that cancer diagnosis plays a protective role in Alzheimer's disease. However, the effect of the cancer diagnosis on general cognitive function/cognitive decline has not been previously examined. The aim of this study was to investigate the relationship between cancer diagnosis and cognitive function and mild cognitive impairment/disorders (MCI/MCD), adjusting for cancer treatments. METHODS: These data were drawn from the Personality and Total Health (PATH) Through Life Study, a population-based Australian cohort study...
January 4, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28052981/variation-in-functional-status-after-hip-fracture-facility-and-regional-influence-on-mobility-and-self-care
#14
Srinivas Teppala, Kenneth J Ottenbacher, Karl Eschbach, Amit Kumar, Soham Al Snih, Winston J Chan, Timothy A Reistetter
BACKGROUND: Recent reports show substantial geographic variation in postacute health care spending. Little is known about variation in functional outcomes after postacute rehabilitation for patients with hip fracture. We examined variation in mobility and self-care after hip fracture rehabilitation across inpatient rehabilitation facilities (IRFs), hospital referral regions (HRRs) and states. METHODS: Retrospective cohort study using data from the Centers for Medicare and Medicaid Services (CMS) from 2006 to 2009...
January 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28052980/metabolites-associated-with-lean-mass-and-adiposity-in-older-black-men
#15
Rachel A Murphy, Steven C Moore, Mary Playdon, Osorio Meirelles, Anne B Newman, Iva Milijkovic, Stephen B Kritchevsky, Ann Schwartz, Bret H Goodpaster, Joshua Sampson, Peggy Cawthon, Eleanor M Simonsick, Robert E Gerszten, Clary B Clish, Tamara B Harris
To identify biomarkers of body mass index, body fat, trunk fat, and appendicular lean mass, nontargeted metabolomics was performed in plasma from 319 black men in the Health, Aging and Body Composition study (median age 72 years, median body mass index 26.8 kg/m(2)). Body mass index was calculated from measured height and weight; percent fat, percent trunk fat, and appendicular lean mass were measured with dual-energy x-ray absorptiometry. Pearson partial correlations between body composition measures and metabolites were adjusted for age, study site, and smoking...
January 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28049634/physical-activity-and-alzheimer-s-disease-a-systematic-review
#16
REVIEW
Ruth Stephen, Kristiina Hongisto, Alina Solomon, Eija Lönnroos
The current literature includes several studies investigating the association between physical activity and risk of Alzheimer's disease (AD). The aim of this review was to systematically evaluate available evidence on this association. Medline via PubMed and CINAHL databases were searched for original English language research articles assessing the relationship between physical activity and incident AD. The review was limited to prospective observational and intervention studies. Criteria for exclusion were studies focusing on individuals with dementia, cross-sectional study design, and case reports...
January 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28043942/a-cognitive-turning-point-in-development-of-clinical-alzheimer-s-disease-dementia-and-mild-cognitive-impairment-a-biracial-population-study
#17
Kumar B Rajan, Robert S Wilson, Lisa L Barnes, Neelum T Aggarwal, Jennifer Weuve, Denis A Evans
BACKGROUND: Cognitive changes during the preclinical phase of Alzheimer's disease (AD) dementia have been characterized among European Americans (EAs), but studies of preclinical changes among African Americans (AAs) are notably absent. METHODS: Preclinical changes in cognition before the development of AD dementia and mild cognitive impairment over a period of 18 years were examined using change points in a biracial sample of 2,125 older adults. RESULTS: Of 2,125 participants, 442 (21%) developed AD dementia and 661 (31%) developed mild cognitive impairment...
January 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28025308/2-5-dimethyl-celecoxib-extends-drosophila-life-span-via-a-mechanism-that-requires-insulin-and-target-of-rapamycin-signaling
#18
Qi Wu, Ting Lian, Xiaolan Fan, Chaochun Song, Uma Gaur, Xueping Mao, Deying Yang, Matthew D W Piper, Mingyao Yang
The search for antiaging drugs is a key component of gerontology research. A few drugs with positive effects on life span in model organisms have been found. Here, we report that 2,5-dimethyl-celecoxib, a derivative of the anti-inflammatory drug celecoxib, can extend Drosophila life span and delay aging by a mechanism involving insulin signaling and target of rapamycin signaling. Importantly, its positive effects were apparent when the treatment window was restricted to the beginning of life or the later half...
December 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28003375/assessing-and-measuring-chronic-multimorbidity-in-the-older-population-a-proposal-for-its-operationalization
#19
Amaia Calderón-Larrañaga, Davide L Vetrano, Graziano Onder, Luis A Gimeno-Feliu, Carlos Coscollar-Santaliestra, Angelo Carfí, Maria S Pisciotta, Sara Angleman, René J F Melis, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Anna-Karin Welmer, Roberto Bernabei, Alexandra Prados-Torres, Alessandra Marengoni, Laura Fratiglioni
BACKGROUND: Although the definition of multimorbidity as "the simultaneous presence of two or more chronic diseases" is well established, its operationalization is not yet agreed. This study aims to provide a clinically driven comprehensive list of chronic conditions to be included when measuring multimorbidity. METHODS: Based on a consensus definition of chronic disease, all four-digit level codes from the International Classification of Diseases, 10th revision (ICD-10) were classified as chronic or not by an international and multidisciplinary team...
December 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28003374/effects-of-calorie-restriction-in-obese-older-adults-the-crossroads-randomized-controlled-trial
#20
Jamy D Ard, Barbara Gower, Gary Hunter, Christine S Ritchie, David L Roth, Amy Goss, Brooks C Wingo, Eric V Bodner, Cynthia J Brown, David Bryan, David R Buys, Marilyn C Haas, Akilah Dulin Keita, Lee Anne Flagg, Courtney P Williams, Julie L Locher
BACKGROUND: We lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life. METHODS: We conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss)...
December 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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