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Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

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https://www.readbyqxmd.com/read/27856493/genetic-and-environmental-effects-on-telomere-length-and-lung-function-a-twin-study
#1
Elina Sillanpää, Sarianna Sipilä, Timo Törmäkangas, Jaakko Kaprio, Taina Rantanen
BACKGROUND: The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. METHODS: 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software...
November 16, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27852636/a-prospective-study-of-back-pain-and-risk-of-falls-among-older-community-dwelling-men
#2
Lynn M Marshall, Stephanie Litwack-Harrison, Una E Makris, Deborah M Kado, Peggy M Cawthon, Richard A Deyo, Nels L Carlson, Michael C Nevitt
BACKGROUND: Musculoskeletal pain is associated with increased fall risk among older men. However, the association of back pain, the most prevalent type of pain in this population, and fall risk is unknown. METHODS: We conducted a prospective investigation among 5,568 community-dwelling U.S. men at least 65 years of age from the Osteoporotic Fractures in Men Study (MrOS). Baseline questionnaires inquired about back pain and its location (such as low back), severity, and frequency in the past year...
November 16, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27836906/does-pain-predict-frailty-in-older-men-and-women-findings-from-the-english-longitudinal-study-of-ageing-elsa
#3
Katie F Wade, Alan Marshall, Bram Vanhoutte, Frederick C W Wu, Terence W O'Neill, David M Lee
BACKGROUND: Pain has been suggested to act as a stressor during aging, potentially accelerating declines in health and functioning. Our objective was to examine the longitudinal association between self-reported pain and the development, or worsening, of frailty among older men and women. METHODS: The study population consisted of 5,316 men and women living in private households in England, mean age 64.5 years, participating in the English Longitudinal Study of Ageing (ELSA)...
November 11, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27816938/genome-wide-association-study-of-parental-life-span
#4
Toshiko Tanaka, Ambarish Dutta, Luke C Pilling, Luting Xue, Kathryn L Lunetta, Joanne M Murabito, Stefania Bandinelli, Robert Wallace, David Melzer, Luigi Ferrucci
BACKGROUND: Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity. METHODS: A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted. RESULTS: A genome-wide significant association was observed for rs35715456 (log10BF = 6...
November 5, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27816937/contributors-to-poor-mobility-in-older-adults-integrating-white-matter-hyperintensities-and-conditions-affecting-other-systems
#5
Andrea L Rosso, Stephanie A Studenski, W T Longstreth, Jennifer S Brach, Robert M Boudreau, Caterina Rosano
BACKGROUND: Age-related mobility limitations are debilitating and common. Cerebral white matter hyperintensities (WMH) and conditions affecting other systems are known contributors, but have been studied in isolation. METHODS: In 2,703 adults aged 65 years or older, we assessed cross-sectional and longitudinal gait speed and mobility disability (self-reported difficulty walking half mile) in those with and without high burden of MRI-defined WMH along with six other conditions (OCs) affecting mobility: gender-specific weak grip; poor self-reported vision; gender-specific lowest quartile of forced vital capacity; self-reported joint pain; ankle-arm index less than 0...
November 5, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27811156/the-importance-of-mid-to-late-life-body-mass-index-trajectories-on-late-life-gait-speed
#6
B Gwen Windham, Michael E Griswold, Wanmei Wang, Anna Kucharska-Newton, Ellen W Demerath, Kelley Pettee Gabriel, Lisa A Pompeii, Kenneth Butler, Lynne Wagenknecht, Stephen Kritchevsky, Thomas H Mosley
BACKGROUND: Prior studies suggest being overweight may be protective against poor functional outcomes in older adults. METHODS: Body mass index (BMI, kg/m(2)) was measured over 25 years across five visits (1987-2011) among Atherosclerosis Risk in Communities Study participants (baseline Visit 1 n = 15,720, aged 45-64 years). Gait speed was measured at Visit 5 ("late-life", aged ≥65 years, n = 6,229). BMI trajectories were examined using clinical cutpoints and continuous mixed models to estimate effects of patterns of BMI change on gait speed, adjusting for demographics and comorbidities...
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27811155/olfaction-is-related-to-motor-function-in-older-adults
#7
Qu Tian, Susan M Resnick, Stephanie A Studenski
BACKGROUND: Among older adults, both olfaction and motor function predict future cognitive decline and dementia, suggesting potential shared causal pathways. However, it is not known whether olfactory and motor function are independently related in late life. METHODS: We assessed cross-sectional associations of olfaction with motor and cognitive function, using concurrent data on olfactory function, mobility, balance, fine motor function, manual dexterity, and cognition in 163 Baltimore Longitudinal Study of Aging participants aged 60 and older without common neurological diseases (n = 114 with available cognitive data)...
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27811154/response-to-letter-from-de-alfieri-et-al-biological-resilience-of-elderly-hospitalized-patients
#8
LETTER
Heather E Whitson, Wei Duan-Porter, Kenneth Schmader, Miriam Morey, Harvey J Cohen, Cathleen Colón-Emeric
No abstract text is available yet for this article.
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27811153/biologic-resilience-of-elderly-hospitalized-patients
#9
LETTER
Walter De Alfieri, Tiziano Borgogni, Sergio Costanzo, Francesca Nisticò
No abstract text is available yet for this article.
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27803098/cerebral-amyloid-deposition-and-dual-tasking-in-cognitively-normal-mobility-unimpaired-older-adults
#10
Neelesh K Nadkarni, Oscar L Lopez, Subashan Perera, Stephanie A Studenski, Beth E Snitz, Kirk I Erickson, Chester A Mathis, Robert D Nebes, Mark Redfern, William E Klunk
BACKGROUND: We examined relationships between cerebral amyloid-beta (Aβ) and cognitive-gait dual-task performance in 27 cognitively normal, mobility unimpaired elders. METHODS: We assessed Aβ on Pittsburgh Compound B (PiB)-PET. We measured gait speed separately and while performing working-memory, response-inhibition, motor-sequencing, and phone-dialing tasks. We compared dual-task costs on gait and cognitive performance in high-Aβ (PiB(+)) and low-Aβ (PiB(-)) groups and examined the association between Aβ and dual-task performance decrements...
November 1, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27803097/utility-of-brief-cognitive-and-physical-assessments-in-clinical-care
#11
EDITORIAL
Stephanie Studenski
No abstract text is available yet for this article.
November 1, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27793966/impact-of-underlying-conditions-on-zoster-related-pain-and-on-quality-of-life-following-zoster
#12
Laurence Torcel-Pagnon, Hélène Bricout, Isabelle Bertrand, Emilia Perinetti, Elisabetta Franco, Giovanni Gabutti, Antonio Volpi
BACKGROUND: Chronic conditions have been investigated as risk factors for developing zoster, but in patients suffering from zoster, the impact of underlying conditions in zoster-related pain and quality of life (QOL) remains unclear. METHODS: We performed a post hoc analysis of a prospective cohort study in immunocompetent zoster patients aged 50 years or older, conducted by general practitioners in Italy between 2009 and 2010. Zoster symptoms, pain intensity and characteristics, and physical and mental health scores were assessed at baseline (zoster diagnosis) and at 1, 3, and 6 months of follow-up...
October 28, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27789618/zinc-deficiency-is-associated-with-depressive-symptoms-results-from-the-berlin-aging-study-ii
#13
Alissa Jung, Dominik Spira, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Kristina Norman
BACKGROUND: Zinc plays an important role for behavioral and mental function, maintaining the correct functions of intracellular signal transduction, cellular and trans-membrane transport, protein synthesis, and antioxidant system. We investigated both dietary zinc intake and plasma zinc levels and the correlation with depressive symptoms in a large sample of community-dwelling old. DESIGN: One thousand five hundred fourteen older people (aged 60-84 years, 772 women) from the Berlin Aging Study II were included...
October 27, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27789617/cytomegalovirus-seropositivity-predicts-a-decline-in-the-t-cell-but-not-the-antibody-response-to-influenza-in-vaccinated-older-adults-independent-of-type-2-diabetes-status
#14
Kamran Haq, Tamas Fulop, Gale Tedder, Beth Gentleman, Hugo Garneau, Graydon S Meneilly, Alison Kleppinger, Graham Pawelec, Janet E McElhaney
Type 2 diabetes mellitus (T2DM) and persistent cytomegalovirus (CMV) infection are postulated contributors to inflammatory processes that impact on the age-related decline in T-cell responses to influenza vaccination. Older subjects with T2DM (n = 30) and healthy aged controls (n = 40) were enrolled and received influenza vaccination in this study. Serum inflammatory markers and CMV serostatus were measured. Pre- to post-vaccination changes in serum antibody titers to the A/H3N2 strain, and levels of granzyme B (GrB, cytotoxic T lymphocytes) in lysates and cytokines in supernatants from influenza A/H3N2-challenged peripheral blood mononuclear cells were measured...
October 27, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27789616/bda-410-treatment-reduces-body-weight-and-fat-content-by-enhancing-lipolysis-in-sedentary-senescent-mice
#15
Andrea S Pereyra, Zhong-Min Wang, Maria Laura Messi, Tan Zhang, Hanzhi Wu, Thomas C Register, Elizabeth Forbes, Nelmi O Devarie-Baez, Daniel Clark Files, Martin C Abba, Cristina Furdui, Osvaldo Delbono
Loss of muscle mass and force with age leads to fall risk, mobility impairment, and reduced quality of life. This article shows that BDA-410, a calpain inhibitor, induced loss of body weight and fat but not lean mass or skeletal muscle proteins in a cohort of sedentary 23-month-old mice. Food and water intake and locomotor activity were not modified, whereas BDA-410 treatment decreased intramyocellular lipid and perigonadal fat, increased serum nonesterified fatty acids, and upregulated the genes mediating lipolysis and oxidation, lean phenotype, muscle contraction, muscle transcription regulation, and oxidative stress response...
October 27, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27784724/association-of-hypoglycemia-with-subsequent-dementia-in-older-patients-with-type-2-diabetes-mellitus
#16
Hemalkumar B Mehta, Vinay Mehta, James S Goodwin
BACKGROUND: Studies have found conflicting evidence regarding the association of hypoglycemia with dementia. We evaluated an association of hypoglycemia with subsequent dementia in patients with type 2 diabetes. METHODS: This retrospective longitudinal cohort study used the Clinical Practice Research Datalink, an electronic medical records data from the United Kingdom, from 2003 to 2012. We included patients aged >65 years diagnosed with type 2 diabetes, with no prior diagnosis of dementia...
October 26, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27907890/association-of-muscle-endurance-fatigability-and-strength-with-functional-limitation-and-mortality-in-the-health-aging-and-body-composition-study
#17
Baback Roshanravan, Kushang V Patel, Linda F Fried, Cassianne Robinson-Cohen, Ian H de Boer, Tamara Harris, Rachel A Murphy, Suzanne Satterfield, Bret H Goodpaster, Michael Shlipak, Anne B Newman, Bryan Kestenbaum
BACKGROUND: Mobility limitation is highly prevalent among older adults and is central to the loss of functional independence. Dynamic isokinetic muscle fatigue testing may reveal increased vulnerability to disability and mortality beyond strength testing. METHODS: We studied community-dwelling older adults enrolled in the Health Aging and Body Composition study (age range: 71-82) free of mobility disability and who underwent isokinetic muscle fatigue testing in 1999-2000 (n = 1,963)...
October 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27753610/hierarchy-and-speed-of-loss-in-physical-functioning-a-comparison-across-older-u-s-and-english-men-and-women
#18
Rebecca Bendayan, Rachel Cooper, Elizabeth G Wloch, Scott M Hofer, Andrea M Piccinin, Graciela Muniz-Terrera
BACKGROUND: We aimed to identify the hierarchy of rates of decline in 16 physical functioning measures in U.S. and English samples, using a systematic and integrative coordinated data analysis approach. METHODS: The U.S. sample consisted of 13,612 Health and Retirement Study participants, and the English sample consisted of 5,301 English Longitudinal Study of Ageing participants. Functional loss was ascertained using self-reported difficulties performing 6 activities of daily living and 10 mobility tasks...
October 17, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27733425/cardiovascular-dysfunction-and-frailty-among-older-adults-in-the-community-the-aric-study
#19
Wilson Nadruz, Dalane Kitzman, Beverly Gwen Windham, Anna Kucharska-Newton, Kenneth Butler, Priya Palta, Michael E Griswold, Lynne E Wagenknecht, Gerardo Heiss, Scott D Solomon, Hicham Skali, Amil M Shah
BACKGROUND: The contribution of cardiovascular dysfunction to frailty in older adults is uncertain. This study aimed to define the relationship between frailty and cardiovascular structure and function, and determine whether these associations are independent of coexisting abnormalities in other organ systems. METHODS: We studied 3,991 older adults (mean age 75.6±5.0 years; 59% female) from the Atherosclerosis Risk in Communities (ARIC) Study in whom the following six organ systems were uniformly assessed: cardiac (by echocardiography), vascular (by ankle-brachial-index and pulse-wave-velocity), pulmonary (by spirometry), renal (by estimated glomerular filtration rate), hematologic (by hemoglobin), and adipose (by body mass index and bioimpedance)...
October 12, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27707806/replication-of-genome-wide-association-study-findings-of-longevity-in-white-african-american-and-hispanic-women-the-women-s-health-initiative
#20
Aladdin H Shadyab, Charles Kooperberg, Alexander P Reiner, Sonia Jain, JoAnn E Manson, Chancellor Hohensee, Caroline A Macera, Richard A Shaffer, Linda C Gallo, Andrea Z LaCroix
BACKGROUND: No study has evaluated whether genetic factors are associated with longevity in African Americans or Hispanics, and it is unclear whether genetic factors are associated with healthy aging. METHODS: In this prospective study, we determined whether 14 genetic variants previously associated with longevity in genome-wide association studies were associated with survival to ages 85 and 90 in 11,053 postmenopausal white, African American, and Hispanic women from the Women's Health Initiative...
October 5, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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