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Journal of Dermatology

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https://www.readbyqxmd.com/read/30402978/instrumental-evaluation-sensitively-detects-subclinical-skin-changes-by-the-epidermal-growth-factor-receptor-inhibitors-and-risk-factors-for-severe-acneiform-eruption
#1
Katsuko Kikuchi, Keiko Nozawa, Naoya Yamazaki, Yasuo Nakai, Ayaka Higashiyama, Masayuki Asano, Yutaka Fujiwara, Shintaro Kanda, Yuichiro Ohe, Atsuo Takashima, Narikazu Boku, Akira Inoue, Masanobu Takahashi, Takahiro Mori, Osamu Taguchi, Yasuhiro Inoue, Hitoshi Mizutani
Epidermal growth factor receptor inhibitors (EGFRI), EGFR tyrosine kinase inhibitors (TKI) and anti-EGFR antibodies commonly develop skin toxicities including acneiform eruption (AfE). However, precise skin changes and risk factors for severe AfE are still unclear. The objective of the current study was elucidation of the useful parameters for early and sensitive detection of the skin changes by EGFRI. Transepidermal water loss (TEWL), skin surface hydration, skin surface lipid levels and erythema/melanin index were serially measured for 2 weeks in 19 EGFR-TKI afatinib/erlotinib-treated patients and for 8 weeks in 20 anti-EGFR antibody cetuximab-treated patients...
November 7, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30402940/improvement-of-nail-lesions-in-a-patient-with-psoriatic-arthritis-by-switching-the-treatment-from-an-anti-interleukin-17a-antibody-to-an-anti-tumor-necrosis-factor-%C3%AE-antibody
#2
LETTER
Takayoshi Komatsu-Fujii, Tetsuya Honda, Atsushi Otsuka, Kenji Kabashima
No abstract text is available yet for this article.
November 7, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30402886/expression-of-t-cell-immunoglobulin-and-immunoreceptor-tyrosine-based-inhibitory-motif-domain-on-cd4-t-cells-in-patients-with-atopic-dermatitis
#3
Miki Kurita, Yuki Yoshihara, Yozo Ishiuji, Mami Chihara, Takaoki Ishiji, Akihiko Asahina, Koichi Yanaba
The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells. Although TIGIT plays an important role in various autoimmune diseases, its role in atopic dermatitis (AD) remains unclear. In this study, we examined the expression levels of TIGIT and their association with clinical features in patients with AD. TIGIT expression on CD4+ T cells, central memory T cells, effector memory T cells and regulatory T cells was determined by flow cytometry...
November 7, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30387862/chinese-case-of-nakajo-nishimura-syndrome-with-a-novel-mutation-of-the-psmb8-gene
#4
LETTER
Xiuyan Shi, Xin Xiang, Zhaoyang Wang, Lin Ma, Zigang Xu
No abstract text is available yet for this article.
November 2, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379358/four-cases-of-paradoxical-cephalocervical-pyogenic-granuloma-during-treatment-with-paclitaxel-and-ramucirumab
#5
LETTER
Rei Watanabe, Eiji Nakano, Akihito Kawazoe, Yasutoshi Kuboki, Hideaki Bando, Kouhei Shitara, Akira Takahashi, Arata Tsutsumida, Aya Nishizawa, Naoya Yamazaki
No abstract text is available yet for this article.
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379353/s%C3%A3-zary-syndrome-without-erythroderma-a-case-report-and-review-of-published-work
#6
Hiroaki Kamijo, Tomomitsu Miyagaki, Yuta Norimatsu, Naomi Shishido-Takahashi, Ai Kuzumi, Yoshihide Asano, Shinichi Sato
Sézary syndrome (SS) is defined by erythroderma and circulating atypical T cells, with or without lymphadenopathy. Recently, Thompson et al. identified a distinct population of SS patients with an atypical presentation: a high blood tumor burden of Sézary cells fulfilling criteria for SS but without fulfilling the criteria for erythroderma at the diagnosis. Here, we report a case of a 49-year-old Japanese man with SS who did not present with erythroderma initially, but exhibited erythematous itchy papules symmetrically located on the legs and arms...
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379352/autophagy-in-malnutrition-associated-dermatoses
#7
Yoji Hirai, Tomoko Miyake, Toshihisa Hamada, Osamu Yamasaki, Shin Morizane, Tatsuhiko Mori, Keiji Iwatsuki
Malnutrition-associated dermatoses including necrolytic migratory erythema (NME) and pellagra share common clinicopathological features; in particular, necrolytic changes in the upper epidermis. Here, we report the involvement of autophagy in the development of necrolysis in three patients with malnutrition-associated dermatoses. First, we examined an autophagy-specific molecule, microtubule-associated protein light chain 3 (LC3), using a monoclonal antibody. LC3 was strongly expressed in the granular layers of the active border, and less intensely observed in the perilesional areas...
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379350/case-of-extranodal-natural-killer-t-cell-lymphoma-nasal-type-accompanied-by-epstein-barr-virus-positive-nasopharyngeal-carcinoma
#8
LETTER
Naoyuki Senda, Tomomitsu Miyagaki, Tomonori Oka, Aya Itoigawa, Kanako Kikuchi, Takashi Kobayashi, Fumihiko Nakamura, Mineo Kurokawa, Makoto Sugaya, Shinichi Sato
No abstract text is available yet for this article.
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379347/effectiveness-of-weekly-paclitaxel-for-edema-and-pain-in-classic-kaposi-sarcoma-with-widespread-eruption-in-the-lower-legs
#9
LETTER
Reina Omura, Riei Kamo, Nao Kusutani, Kazuyoshi Fukai, Toshiyuki Ozawa, Ryouko Awazawa, Masahiko Osawa, Daisuke Tsuruta
No abstract text is available yet for this article.
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379346/association-between-rosacea-severity-and-relative-muscle-mass-a-cross-sectional-study
#10
Jae-Hui Nam, Junghwa Yang, Jiho Park, Je Hyun Seo, Yoosoo Chang, Seungho Ryu, Won-Serk Kim
Rosacea is thought to be associated with factors involved in metabolic syndrome (MetS). Muscle mass has a beneficial role in preventing MetS, but its link to rosacea remains unknown. We sought to investigate the association between rosacea severity and relative skeletal muscle mass. A cross-sectional study was conducted on subjects who attended a skin check-up program at the Kangbuk Samsung Hospital Health Screening Center between 2014 and 2016. Polarized light photographs of the face were taken and evaluated by two dermatologists...
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379345/high-grade-trichoblastic-carcinoma-arising-through-malignant-transformation-of-trichoblastoma-immunohistochemical-analysis-and-the-expression-of-p53-and-phosphorylated-akt
#11
Takayuki Fusumae, Keiji Tanese, Asako Takeuchi, Arisa Takasugi, Rino Kawakita, Junichi Shiraishi, Tetsuya Yoshida
Trichoblastoma (TB) is a benign cutaneous adnexal neoplasm. The lesion typically presents as a slow-growing, solitary, well-circumscribed nodule measuring up to 3 cm in diameter. On rare occasions, TB causes malignant transformation into an aggressive form described as high-grade trichoblastic carcinoma. Four such cases have been reported to date; all were described as high-grade trichoblastic carcinomas. Here, we describe the case of a 72-year-old Japanese male patient with a rapidly enlarging subcutaneous tumor on his lower back, which was diagnosed as high-grade trichoblastic carcinoma...
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30379342/two-cases-of-chronic-oral-ulcers-effectively-treated-with-systemic-corticosteroid-therapy-circumorificial-plasmacytosis-and-traumatic-ulcerative-granuloma-with-stromal-eosinophilia
#12
Yuko Kuriyama, Akira Shimizu, Sayaka Toki, Yukie Endo, Masahito Yasuda, Sei-Ichiro Motegi, Osamu Ishikawa
Chronic oral ulcers are induced by various causative factors. Biopsy from an active site around ulceration is critical for both the definitive diagnosis and proper treatment. We report two cases of chronic oral ulcers, circumorificial plasmacytosis (CP) and traumatic ulcerative granuloma with stromal eosinophilia (TUGSE). A 65-year-old man presented with a mucosal ulcer on the right half of the lower lip. The dense plasmacytic inflammatory infiltration was histologically consistent with CP. A 32-year-old woman presented with a mucosal ulcer on the right mouth commissure...
October 31, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30368876/impact-of-chronic-urticaria-on-systemic-lupus-erythematosus-a-nationwide-population-based-study-in-taiwan
#13
Su-Boon Yong, Kuan-Wen Su, Huang-Hsi Chen, Jing-Yang Huang, Hsing-Ju Wu, James Cheng-Chung Wei
Chronic urticaria (CU) may be closely pathogenically related to systemic lupus erythematosus (SLE). This study aims to investigate the association between CU and SLE patients in Taiwan. A nationwide population-based cohort study from 1997 to 2013 was conducted. Investigated subjects were selected from the Taiwan National Health Insurance Research Database using the International Classification of Disease, Ninth Revision code. Participants consisted of 13 845 subjects newly diagnosed with CU from 2003 to 2013...
October 27, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30368866/cytotoxic-t-lymphocyte-associated-protein-4-expressed-by-melanoma-cells-does-not-affect-melanoma-specific-cytotoxic-t-lymphocytes-in-the-effector-phase
#14
Takashi Inozume, Ken-Ichi Hanada, Kazuyo Takeda, Tatsuo Maeda, Kazutoshi Harada, Tatsuyoshi Kawamura
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is one of the important molecules that regulate the anti-melanoma T-cell response. Currently, there are some reports showing that CTLA-4 is expressed not only by T cells but also by various kinds of tumor cells, including melanoma cells. However, there is no report that shows the role of CTLA-4 expressed by melanoma cells in melanoma-specific cytotoxic T-lymphocyte (CTL) response. In this report, we confirmed substantial CTLA-4 expression and the localization of CTLA-4 in melanoma cell lines and tissues...
October 27, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30368862/rasa-1-somatic-second-hit-mutation-in-capillary-malformation-arteriovenous-malformation
#15
Ren Cai, Fatao Liu, Yun Liu, Hui Chen, Xiaoxi Lin
No abstract text is available yet for this article.
October 27, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30362593/is-chemotherapy-the-best-option-for-chronic-lymphocytic-leukemia-associated-wells-syndrome-reply-to-case-of-wells-syndrome-a-rare-association-with-the-clinical-course-of-chronic-lymphocytic-leukemia
#16
LETTER
Roberto Maglie, Lavinia Quintarelli, Marzia Caproni, Emiliano Antiga
No abstract text is available yet for this article.
October 26, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30353917/thrombocytopenia-in-a-psoriatic-patient-sequentially-treated-with-adalimumab-secukinumab-and-ustekinumab
#17
LETTER
Takeshi Nakahara, Sawako Konishi, Yumi Yasukochi, Hitokazu Esaki, Gaku Tsuji, Makiko Kido-Nakahara, Masutaka Furue
No abstract text is available yet for this article.
October 24, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30353916/hypomelanotic-melanoma-simulating-pigmented-bowen-s-disease-and-its-challenging-dermoscopic-features
#18
LETTER
Shinji Ogawa, Takeshi Namiki, Chie Uchida, Kohei Nojima, Keiko Miura, Masaru Tanaka, Hiroo Yokozeki
No abstract text is available yet for this article.
October 24, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30353913/eruptive-keratoacanthoma-with-spontaneous-regression-arising-from-a-cervical-squamous-cell-carcinoma-patient-treated-with-nivolumab
#19
LETTER
Taku Fujimura, Chinbing Lyu, Akira Tsukada, Yota Sato, Yumi Kambayashi, Setsuya Aiba
No abstract text is available yet for this article.
October 24, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30353912/study-on-the-correlation-between-age-and-changes-in-mosquito-bite-response
#20
Keiko Oka, Noriko Ohtaki, Ken Igawa, Hiroo Yokozeki
Mosquito bite reactions consist of an immediate response characterized by an erythema and a wheal, which peaks at 20 min, and a delayed response characterized by a papule and/or an erythema, which peaks at 24 h. Mosquito bite reactions progress from stage I to stage V as an individual is repeatedly bitten as follows: stage I, neither immediate nor delayed reaction; stage II, delayed reaction; stage III, both immediate and delayed reaction; stage IV, immediate reaction; and stage V, neither immediate nor delayed reaction...
October 24, 2018: Journal of Dermatology
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