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Journal of Dermatology

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https://www.readbyqxmd.com/read/30230584/successful-treatment-of-refractory-juvenile-generalized-pustular-psoriasis-with-secukinumab-monotherapy-a-case-report-and-review-of-published-work
#1
Po-Han Ho, Tsen-Fang Tsai
Juvenile generalized pustular psoriasis (GPP) is rare and often resistant to conventional systemic therapy such as methotrexate, retinoic acid and cyclosporin A. GPP can be induced by deficiency of interleukin (IL)-36 receptor antagonist (DITRA). No standardized guidelines are available for juvenile GPP or DITRA, and a uniformly safe and effective biologic agent has not been identified. However, multiple biologics approved for use in plaque-type psoriasis have also been used in GPP. Herein, we report a case of a 6-year-old Taiwanese boy with GPP and homozygous mutation at c...
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230582/anti-pl-12-antibody-positive-antisynthetase-syndrome-with-recurrent-digital-ulcers
#2
LETTER
Fumi Miyagawa, Hiroaki Azukizawa, Tsuneyo Mimori, Hideo Asada
No abstract text is available yet for this article.
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230579/distant-recurrence-of-merkel-cell-carcinoma-after-spontaneous-regression
#3
LETTER
Yuka Kobayashi, Motoki Nakamura, Hiroshi Kato, Akimichi Morita
No abstract text is available yet for this article.
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230578/epidemiology-of-pyoderma-gangrenosum-in-japanese-patients-by-questionnaire-survey
#4
LETTER
Toshiyuki Yamamoto
No abstract text is available yet for this article.
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230576/primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type-localized-in-the-right-periorbital-region
#5
LETTER
Shin-Ichi Osada, Yusuke Fujiwara, Naoyuki Higashi, Kazutaka Nakayama, Masaru Hosone, Koiti Inokuchi, Hidehisa Saeki
No abstract text is available yet for this article.
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230572/japanese-guidelines-for-the-management-and-treatment-of-generalized-pustular-psoriasis-the-new-pathogenesis-and-treatment-of-gpp
#6
LETTER
Hideki Fujita, Tadashi Terui, Koremasa Hayama, Masashi Akiyama, Shigaku Ikeda, Tomotaka Mabuchi, Akira Ozawa, Takuro Kanekura, Michiko Kurosawa, Mayumi Komine, Kimiko Nakajima, Shigetoshi Sano, Osamu Nemoto, Masahiko Muto, Yasutomo Imai, Kiyofumi Yamanishi, Yumi Aoyama, Keiji Iwatsuki
Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as a collaborative project between the Japanese Dermatological Association and the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labour, and Welfare Research Project on Overcoming Intractable Diseases. The aim of the guidelines was to provide current information to aid in the treatment of patients with GPP in Japan...
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230569/case-of-psoriatic-erythroderma-induced-by-the-discontinuation-of-the-chronic-use-of-topical-steroid-after-dialysis-initiation-and-successfully-treated-with-secukinumab
#7
LETTER
Tomoyuki Shibata, Jun Muto, Hiroyuki Takama, Takeshi Yanagishita, Tatsuo Ito, Daisuke Watanabe
No abstract text is available yet for this article.
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30230567/bone-scintigraphy-analysis-of-44-cases-of-pustulotic-arthro-osteitis-associated-with-palmoplantar-pustulosis
#8
LETTER
Tomoko Hiraiwa, Toshiyuki Yamamoto
No abstract text is available yet for this article.
September 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30222206/alopecia-areata-and-overt-thyroid-diseases-a-nationwide-population-based-study
#9
Tae Young Han, June Hyunkyung Lee, Tai Kyung Noh, Min Wha Choi, Jae-Seung Yun, Kyung Ho Lee, Jung Min Bae
An association between alopecia areata (AA) and other autoimmune diseases has been reported. We investigated the associations between AA and overt autoimmune thyroid diseases. A nationwide, population-based, cross-sectional study was performed using the Korea National Health Insurance claims database. We defined patients with AA as those whose records showed at least four physician contacts in which AA, alopecia totalis (AT) or alopecia universalis (AU) was the principal diagnosis. We also established an age- and sex-matched control group without AA...
September 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30222205/comparison-of-oxidative-stress-on-dna-protein-and-lipids-in-patients-with-actinic-keratosis-bowen-s-disease-and-squamous-cell-carcinoma
#10
Asuka Yoshifuku, Kazuyasu Fujii, Takuro Kanekura
Detailed mechanisms on the effect of oxidative stress (OS), an etiological factor involved in photocarcinogenesis, remain to be fully elucidated. We used immunohistochemical methods to study OS in the DNA, protein and lipids of patients with actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC). Between January 2009 and December 2014, we treated 230 patients; 79 had AK, 61 had (BD) and 90 had cutaneous SCC; 28 healthy subjects served as the normal controls. OS on DNA, protein and lipids was assessed by the expression of 8-hydroxydeoxyguanosine (8-OHdG), dityrosine (DT) and malondialdehyde (MDA), respectively...
September 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30222203/acquisition-of-resistance-to-vemurafenib-leads-to-interleukin-10-production-through-an-aberrant-activation-of-akt-in-a-melanoma-cell-line
#11
Takashi Inozume, Toshiyuki Tsunoda, Takashi Morisaki, Kazutoshi Harada, Seiji Shirasawa, Tatsuyoshi Kawamura
Serine/threonine-protein kinase B-Raf (BRAF) inhibitors are very effective in treating melanoma with BRAF mutations. BRAF inhibitors suppress aberrant growth of melanoma cells caused by BRAF mutations. BRAF mutations reportedly result in melanoma cells releasing immunosuppressive factors, and BRAF inhibitors elicit anti-melanoma immune responses by reducing such factors. However, immunological characteristics of tumor cells that acquire resistance to BRAF inhibitors remain unknown. Here, we compared immunological characteristics between a melanoma cell line and its vemurafenib-resistant subline...
September 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30222202/intestinal-barrier-integrity-in-patients-with-plaque-psoriasis
#12
Mariusz Sikora, Magdalena Chrabąszcz, Cezary Maciejewski, Michał Zaremba, Anna Waśkiel, Małgorzata Olszewska, Lidia Rudnicka
Psoriasis is a chronic inflammatory systemic disease. Growing evidence suggests that human homeostasis depends on a mutualistic relationship with gut bacteria that produce a number of biologically active compounds. Therefore, enteric microbiota dysbiosis with gut barrier disruption may be an important factor in the development of chronic inflammatory diseases. The aim of our study was to assess non-invasive markers of intestinal barrier integrity in patients with moderate to severe psoriasis. Concentrations of claudin-3 (intestinal epithelial tight junction structure) and intestinal fatty acid binding protein (I-FABP; marker of enterocyte damage) were determined in the blood of patients with chronic plaque psoriasis (n = 20) and healthy individuals (n = 20) using commercially available enzyme-linked immunoassay test kits...
September 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30216499/successful-outcome-of-early-ambulation-after-extensive-skin-grafting-in-extramammary-paget-s-disease
#13
Takuya Maeda, Koji Yoshino, Kojiro Nagai, Satoe Oaku, Megumi Kato, Hiroo Hata
Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy that mainly affects the senior population. There is a relatively high risk of postoperative complications from surgery in the senior population, such as disuse syndrome, deep vein thrombosis and postoperative delirium. To prevent such postoperative complications, early ambulation is recommended. However, EMPD often requires extensive skin grafting because of the need for a large resection margin. To avoid skin graft failure, many institutions require that patients have several days of postoperative bedrest...
September 14, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30216496/paraneoplastic-pemphigus-presenting-lichen-planus-like-lesions
#14
LETTER
Kazunori Okahashi, Naoki Oiso, Norito Ishii, Shusuke Uchida, Shigeto Yanagihara, Akiko Sano, Yuji Tohda, Takashi Hashimoto, Daisuke Tsuruta, Akira Kawada
No abstract text is available yet for this article.
September 14, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30216494/serum-fatty-acid-binding-protein-4-level-is-inversely-correlated-with-serum-thymus-and-activation-regulated-chemokine-level-in-psoriatic-patients-achieving-clear-skin-by-biologics
#15
LETTER
Masaru Honma, Takashi Shibuya, Shin Iinuma, Akemi Ishida-Yamamoto
No abstract text is available yet for this article.
September 14, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30204267/serum-kl-6-levels-in-japanese-patients-with-psoriasis-treated-with-secukinumab
#16
LETTER
Miki Kurita, Sota Kikuchi, Yoshinori Umezawa, Akihiko Asahina, Hidemi Nakagawa, Koichi Yanaba
No abstract text is available yet for this article.
September 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30204266/use-of-immune-checkpoint-inhibitors-prolonged-overall-survival-in-a-japanese-population-of-advanced-malignant-melanoma-patients-retrospective-single-institutional-study
#17
Yoshiyuki Nakamura, Yasuhiro Fujisawa, Ryota Tanaka, Hiroshi Maruyama, Yosuke Ishitsuka, Naoko Okiyama, Rei Watanabe, Manabu Fujimoto
Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised mainly white populations, in which superficial spreading melanoma (SSM) and lentigo maligna melanoma are the major clinical types of melanoma. In contrast, Asians manifest a distinct clinicopathological type of melanoma from that of whites and show much higher frequencies of acral lentiginous melanoma (ALM) and mucosal melanoma, which have been shown to be less susceptible to immune checkpoint inhibitors...
September 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30204265/remission-of-psoriasis-with-nintedanib-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#18
LETTER
Akari Murata, Satoshi Watanabe, Yuka Ikawa, Keigo Saeki, Kenta Yamamura, Hiroki Matsuoka, Kota Tanimura, Yuichi Tambo, Kazuo Kasahara
No abstract text is available yet for this article.
September 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30204264/epidermal-mast-cells-in-bowenoid-papulosis-during-topical-imiquimod-therapy
#19
LETTER
Takako Miura, Toshiyuki Yamamoto
No abstract text is available yet for this article.
September 11, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30204259/therapeutic-synergy-between-contact-dermatitis-from-a-wig-fixing-device-and-tofacitinib-on-alopecia-areata
#20
LETTER
Ji Su Lee, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
No abstract text is available yet for this article.
September 11, 2018: Journal of Dermatology
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