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Journal of Clinical Psychiatry

Taiki Sugimoto, Rei Ono, Ai Kimura, Naoki Saji, Shumpei Niida, Kenji Toba, Takashi Sakurai
OBJECTIVE: The aim of this study was to clarify the association of physical frailty with behavioral and psychological symptoms of dementia (BPSD) and caregiver burden in patients with Alzheimer's disease (AD). METHODS: The subjects were 1,193 AD patients who presented to the Memory Clinic at the National Center for Geriatrics and Gerontology of Japan during the period from October 2010 to February 2015 (mean ± SD age = 78.8 ± 6.3 years; female, 68.6%). AD was diagnosed based on the criteria of the National Institute on Aging and Alzheimer's Association workgroups...
November 13, 2018: Journal of Clinical Psychiatry
Hélène Vulser, Emmanuel Wiernik, Nicolas Hoertel, Maria Melchior, Mura Thibault, Romain Olekhnovitch, Philippe Fossati, Frédéric Limosin, Marcel Goldberg, Marie Zins, Cédric Lemogne
OBJECTIVE: This large-scale population-based prospective study examined the association between depressive symptoms and cognitive performance at baseline with later functioning in middle-aged adults. METHODS: The Center for Epidemiologic Studies Depression Scale, the Digit Symbol Substitution Test (DSST), the Trail Making Test B (TMT-B), and the Semantic Verbal Fluency test (SVF) were completed at baseline by 7,426 participants aged ≥ 45 years from February 2012 to December 2013...
November 13, 2018: Journal of Clinical Psychiatry
Talia L Brown, Peter M Gutierrez, Gary K Grunwald, Carolyn DiGuiseppi, Robert J Valuck, Heather D Anderson
OBJECTIVE: Whether physical access to psychotropic medication via prescription (ie, prescribed access) is associated with use of psychotropic medication as a means of subsequent suicide attempt remains unclear. In a population of suicide attempters, we investigated whether prescribed access to any psychotropic medication increased the likelihood of using any psychotropic drug in a suicide attempt and whether prescribed access to a specific psychotropic drug type increased the likelihood of using that specific psychotropic drug type in an attempt...
November 6, 2018: Journal of Clinical Psychiatry
Nicole Kozloff, Binu Jacob, Aristotle N Voineskos, Paul Kurdyak
OBJECTIVE: Emergency departments (EDs) are often the first point of care for youth with psychotic disorders; however, the care and aftercare they receive have not been well described. The aim of this study was to examine care and aftercare following first ED visit for psychotic disorder among youth. METHODS: We conducted a population-based retrospective cohort study of first ED presentations for psychotic disorder among youth 16 to 24 years old (N = 2,875) in Ontario, Canada...
November 6, 2018: Journal of Clinical Psychiatry
Joseph F Goldberg
No abstract text is available yet for this article.
October 30, 2018: Journal of Clinical Psychiatry
Randi Melissa Schuster, Jodi Gilman, David Schoenfeld, John Evenden, Maya Hareli, Christine Ulysse, Emily Nip, Ailish Hanly, Haiyue Zhang, A Eden Evins
OBJECTIVE: Associations between adolescent cannabis use and poor neurocognitive functioning have been reported from cross-sectional studies that cannot determine causality. Prospective designs can assess whether extended cannabis abstinence has a beneficial effect on cognition. METHODS: Eighty-eight adolescents and young adults (aged 16-25 years) who used cannabis regularly were recruited from the community and a local high school between July 2015 and December 2016...
October 30, 2018: Journal of Clinical Psychiatry
Wenjing Wei, Helmet T Karim, Chemin Lin, Akiko Mizuno, Carmen Andreescu, Jordan F Karp, Charles F Reynolds, Howard J Aizenstein
OBJECTIVE: Studies have identified longitudinally that there exists an association between depression, cerebral blood flow (CBF), and white matter hyperintensities that are thought to be due to vascular pathologies in the brain. However, the changes in CBF, a measure that reflects cerebrovascular integrity, following pharmacotherapy are not well understood. In this study, we investigated the dynamic CBF changes over the course of antidepressant treatment and the association of these changes with depressive symptoms...
October 23, 2018: Journal of Clinical Psychiatry
Subhajit Chakravorty, Rachel V Smith, Michael L Perlis, Michael A Grandner, Henry R Kranzler
OBJECTIVE: Alcohol intoxication and dependence are risk factors for suicide, a leading cause of death in the United States. We examined the hours of peak and nadir in completed suicides over a 24-hour period among intoxicated, alcohol-dependent individuals. We also evaluated suicide-related factors associated with intoxication at different times of the day. METHODS: We analyzed cross-sectional data from the 2003-2010 National Violent Death Reporting System provided by 16 US states...
October 23, 2018: Journal of Clinical Psychiatry
Rishi Deka, Craig J Bryan, Joanne LaFleur, Gary Oderda, Abril Atherton, Vanessa Stevens
OBJECTIVE: To evaluate the relationships between benzodiazepine use and (1) health care utilization and (2) suicide risk in veterans diagnosed with posttraumatic stress disorder (PTSD). METHODS: This propensity-matched retrospective cohort study included veterans diagnosed with 1 ICD-9 code for PTSD who were active users of the Veterans Affairs health care system between January 1, 2001, and December 31, 2014. Exposure included at least 1 thirty-day prescription of a benzodiazepine within 1 year following PTSD diagnosis among patients with no recent history of benzodiazepine use...
October 23, 2018: Journal of Clinical Psychiatry
Carlos Blanco, Beth Han, Christopher M Jones, Kimberly Johnson, Wilson M Compton
OBJECTIVE: Although benzodiazepine misuse and use disorders are associated with adverse health effects, it is unknown what proportion of benzodiazepine users misuse them or meet criteria for benzodiazepine use disorders. The goal of this study was to examine the prevalence and correlates of benzodiazepine use, misuse, and use disorders among US adults. METHODS: Data from 102,000 adults 18 years and older who participated in the 2015-2016 National Surveys on Drug Use and Health were used...
October 16, 2018: Journal of Clinical Psychiatry
Hsuan-Kan Chang, Ju-Wei Hsu, Jau-Ching Wu, Kai-Lin Huang, Huang-Chou Chang, Ya-Mei Bai, Tzeng-Ji Chen, Mu-Hong Chen
OBJECTIVE: Early childhood (< 3 years of age) is a critical period for neurodevelopment. This study investigated the correlation between early childhood traumatic brain injury (TBI) and subsequent risk of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental delay (DD) by analyzing a national-scale cohort. METHODS: Data from the National Health Insurance Research Database, which comprises health care information from > 99% of the Taiwanese population, were analyzed...
October 16, 2018: Journal of Clinical Psychiatry
Rachel Pascal de Raykeer, Nicolas Hoertel, Carlos Blanco, Mark Olfson, Melanie Wall, Anne-Sophie Seigneurie, Jean-Pierre Schuster, Cédric Lemogne, Armin von Gunten, Frédéric Limosin
OBJECTIVE: Several common psychiatric disorders are associated with increased risk of suicide attempts, and the strength of these associations may vary between younger and older adults, which may explain age differences in suicide risk. Because psychiatric disorders often co-occur, it remains unclear whether (1) the risk of suicide attempt in older and younger adults is due to specific psychiatric disorders or underlying psychopathology dimensions (ie, internalizing and externalizing dimensions) and (2) the extent to which individual psychiatric disorders make distinct contributions to suicide attempt risk varies by age...
October 9, 2018: Journal of Clinical Psychiatry
Paraskevi Mavrogiorgou, Björn Enzi, Saskia Steinmann, Christoph Mulert, Georg Juckel
OBJECTIVE: The so-called neuroanatomical hypothesis (with an increased activity of orbitofrontal cortex [OFC]) and the serotonergic hypothesis (with low activity in this system) have been discussed regarding the pathogenesis of obsessive-compulsive disorder (OCD) for decades. This study aimed to look for a relationship between the 2 pathogenetic concepts. METHODS: Nineteen OCD patients (8 female, 11 male, mean ± SD age = 33.37 ± 11.73 years, Yale-Brown Obsessive Compulsive Scale: 21...
October 9, 2018: Journal of Clinical Psychiatry
Chittaranjan Andrade
In different parts of the world, pregabalin is an approved treatment for neuropathic pain syndromes, fibromyalgia, partial-onset seizures, and generalized anxiety disorder. Few studies have examined the safety of pregabalin exposure during pregnancy. Among 4 studies identified through a PubMed search conducted in September 2018, one small study (exposed n = 30) recorded a major malformation rate of 3.3%, which was similar to that in unexposed controls. Another small study (exposed n = 30) recorded increased rates of spontaneous abortion (23...
October 2, 2018: Journal of Clinical Psychiatry
Jasmina Mallet, Nicolas Mazer, Caroline Dubertret, Yann Le Strat
OBJECTIVE: Recent findings suggest an association between tobacco and psychosis, but whether this association is mediated by confounding factors is unknown. Psychosis-like experiences (PLEs) are a subclinical expression of psychosis. To disentangle the association of tobacco with PLEs, we examined data from a large US population-based, nationally representative sample. METHODS: Analysis was conducted on Wave 2 of the National Epidemiologic Survey of Alcohol and Related Conditions (N = 34,653 adults, conducted from 2004 to 2005)...
October 2, 2018: Journal of Clinical Psychiatry
Florian Walter, Matthew J Carr, Pearl L H Mok, Sussie Antonsen, Carsten B Pedersen, Jenny Shaw, Roger T Webb
OBJECTIVE: Persons discharged from inpatient psychiatric units are at greatly elevated risk of dying unnaturally. We conducted a comprehensive examination of specific causes of unnatural death post-discharge in a national register-based cohort. METHOD: A cohort of 1,683,645 Danish residents born 1967-1996 was followed from their 15th birthday until death, emigration, or December 31, 2011, whichever came first. Survival analysis techniques were used to estimate incidence rate ratios (IRRs) comparing risk for persons with and without psychiatric admission history in relation to (a) suicide method, (b) accidental death type, (c) fatal poisoning type, and (d) homicide...
October 2, 2018: Journal of Clinical Psychiatry
Chittaranjan Andrade
A very large number of psychopharmacologic agents have been trialed as antipsychotic augmentation strategies for the improvement of positive, negative, mood, cognitive, and other symptoms of schizophrenia; statins are one among these. Two very recent meta-analyses examined data on statin augmentation from 5 to 6 randomized controlled trials (RCTs) in the field. One meta-analysis found that statins were superior to placebo for the improvement of total scale and general psychopathology subscale scores on the Positive and Negative Syndrome Scale; statins were no better than placebo for positive and negative subscale outcomes...
September 25, 2018: Journal of Clinical Psychiatry
Guillaume Vaiva, Sofian Berrouiguet, Michel Walter, Philippe Courtet, François Ducrocq, Vincent Jardon, Mark E Larsen, Lionel Cailhol, Carole Godesense, Christophe Couturier, Anjali Mathur, Virginie Lagree, Catherine Pichene, David Travers, Cedric Lemogne, Jean Marc Henry, Frederic Jover, Francoise Chastang, Olivier Prudhomme, Philippe Lestavel, Catherine Thevenon Gignac, Stéphane Duhem, Anne Laure Demarty, Catherine Mesmeur, Frank Bellivier, Julien Labreuche, Alain Duhamel, Patrick Goldstein
BACKGROUND: There is growing evidence in the literature that brief contact interventions (BCIs) might be reliable suicide prevention strategies. OBJECTIVE: To assess the effectiveness of a decision-making algorithm for suicide prevention (ALGOS) combining existing BCIs in reducing suicide reattempts in patients discharged after a suicide attempt. METHODS: A randomized, multicenter, controlled, parallel trial was conducted in 23 hospitals. The study was conducted from January 26, 2010, to February 28, 2013...
September 25, 2018: Journal of Clinical Psychiatry
Martha Sajatovic, Curtis Tatsuoka, Kristin A Cassidy, Peter J Klein, Edna Fuentes-Casiano, Jamie Cage, Michelle E Aebi, Luis F Ramirez, Carol Blixen, Adam T Perzynski, Mark S Bauer, Steven A Safren, Jennifer B Levin
OBJECTIVE: Nonadherence in bipolar disorder (BD) ranges from 20% to 60%. Customized adherence enhancement (CAE) is a brief, BD-specific approach that targets individual adherence barriers. This prospective, 6-month, randomized controlled trial conducted from October 2012 to July 2017 compared CAE versus a rigorous BD-specific educational program (EDU) on adherence, symptoms, and functional outcomes in poorly adherent individuals. METHODS: One hundred eighty-four participants with DSM-IV BD were randomized to CAE (n = 92) or EDU (n = 92)...
September 25, 2018: Journal of Clinical Psychiatry
Chih-Ming Cheng, Wen-Han Chang, Yu-Chuan Chiu, Yu Sun, Huey-Jane Lee, Li-Yu Tang, Pei-Ning Wang, Ming-Jang Chiu, Cheng-Hung Yang, Shih-Jen Tsai, Chia-Fen Tsai
BACKGROUND: Polypharmacy, defined as the concomitant use of 5 or more medications, has a documented negative association with cognitive impairment such as delirium and is associated, potentially, with a higher risk of dementia. However, whether polypharmacy contributes to increased risk of mild cognitive impairment (MCI) or decreased cognitive capacity requires further investigation. This nationwide population survey investigated the association among polypharmacy, MCI, and dementia. METHODS: Through random sampling based on the proportion of all Taiwan counties, subjects were recruited and received in-person interviews between December 2011 and March 2013...
September 25, 2018: Journal of Clinical Psychiatry
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