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Journal of Clinical Psychiatry

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https://www.readbyqxmd.com/read/29419948/treatment-refractory-obsessive-compulsive-disorder-in-adults-a-cost-effectiveness-analysis-of-treatment-strategies
#1
Sean T Gregory, Brian Kay, Joseph Smith, Kristin Hall, Alessandro S De Nadai, Troy Quast, Bradley C Riemann, Eric A Storch
OBJECTIVE: This study sought to assess the cost-effectiveness of 7 treatment strategies for treatment-refractory obsessive-compulsive disorder (OCD) in adults. METHODS: A model was developed to evaluate treatment alternatives for adults (18-64 years old) that consisted of 2 parts: a decision analytic model and a Markov model. The decision analytic model stratified 7 outpatient treatment strategies, and the Markov model accumulated benefits and costs across the life expectancy of a simulated cohort of individuals...
February 6, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29419949/depression-with-mixed-features-in-major-depressive-disorder-a-new-diagnosis-or-there-all-along
#2
Michael J Ostacher, Trisha Suppes
No abstract text is available yet for this article.
January 30, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29370485/validity-of-the-maudsley-staging-method-in-predicting-treatment-resistant-depression-outcome-using-the-netherlands-study-of-depression-and-anxiety
#3
Sjoerd M van Belkum, Hanneke H Geugies, Thom S Lysen, Anthony J Cleare, Frenk P M L Peeters, Brenda W J H Penninx, Robert A Schoevers, Eric G Ruhe
OBJECTIVE: We investigated if the degree of treatment resistance of depression, as measured by the Maudsley Staging Method (MSM), is predictive of a worse depression outcome by using a large naturalistic cohort of depressed patients. METHODS: 643 subjects from the general population, primary care, and secondary care who suffered from current depressive disorder were included from the Netherlands Study of Depression and Anxiety baseline assessment. The diagnostic criterion was major depressive disorder (MDD) in the last month, based on the Composite Interview Diagnostic Instrument (CIDI), or a CIDI diagnosis of MDD in the past 6 months with an Inventory of Depressive Symptomatology Self-Report score > 24 at baseline...
January 23, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29370484/risk-of-major-congenital-malformations-associated-with-the-use-of-methylphenidate-or-amphetamines-in-pregnancy
#4
Chittaranjan Andrade
The use of prescription psychostimulants during pregnancy has been increasing in recent years. One large and 3 small studies have recently examined the risk of major congenital malformations following the use of methylphenidate and amphetamines during the first trimester of pregnancy. The broad findings of these studies are that first trimester gestational exposure to methylphenidate or amphetamines is associated with an increased risk of major congenital malformations but the associations are no longer statistically significant after adjusting analyses for confounding variables; that first trimester exposure to amphetamines is not associated with an increased risk of cardiovascular malformations; and that first trimester exposure to methylphenidate may increase the risk of cardiovascular malformations...
January 23, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29370483/reconsidering-insomnia-as-a-disorder-rather-than-just-a-symptom-in-psychiatric-practice
#5
Ruth M Benca, Daniel J Buysse
Insomnia is a common feature of many psychiatric disorders but can also be a comorbid disorder, often contributing to poor outcomes and treatment failure. For some patients who do respond to psychiatric treatment, their insomnia persists after their mood symptoms have remitted, indicating that their insomnia needs to be a separate focus of treatment. In this CME Academic Highlights, Drs Ruth Benca and Daniel Buysse discuss how to effectively evaluate patients with psychiatric disorders for comorbid insomnia, as well as how to safely and effectively implement both behavioral and pharmacologic treatments...
January 23, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29360290/facial-emotion-recognition-performance-differentiates-between-behavioral-variant-frontotemporal-dementia-and-major-depressive-disorder
#6
Isabelle Chiu, Olivier Piguet, Janine Diehl-Schmid, Lina Riedl, Johannes Beck, Thomas Leyhe, Edith Holsboer-Trachsler, Reto W Kressig, Manfred Berres, Andreas U Monsch, Marc Sollberger
OBJECTIVE: Misdiagnosis of early behavioral variant frontotemporal dementia (bvFTD) with major depressive disorder (MDD) is not uncommon due to overlapping symptoms. The aim of this study was to improve the discrimination between these disorders using a novel facial emotion perception task. METHOD: In this prospective cohort study (July 2013-March 2016), we compared 25 patients meeting Rascovsky diagnostic criteria for bvFTD, 20 patients meeting DSM-IV criteria for MDD, 21 patients meeting McKhann diagnostic criteria for Alzheimer's disease dementia, and 31 healthy participants on a novel emotion intensity rating task comprising morphed low-intensity facial stimuli...
January 16, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325240/advanced-topics-in-major-depressive-disorder-practical-strategies-to-improve-remission
#7
Rakesh Jain
Health Spectrum is a dynamic platform designed for healthcare professionals who want more from their educational experience. Enter our "virtual office," where 2 interactive patient cases allow you to explore practical considerations for patients with recurrent depression despite adequate trials of antidepressants.
January 9, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325239/insomnia-and-psychopathological-features-associated-with-restless-legs-syndrome-in-chinese-adolescents
#8
Xianchen Liu, Hua Chen, Zhen-Zhen Liu, Cun-Xian Jia
OBJECTIVE: Little is known about psychopathological features associated with restless legs syndrome (RLS) in pediatric populations. This study examined sleep duration, insomnia, and psychopathological profile associated with RLS in a large community sample of adolescents. Methods: Participants included 11,831 adolescents from 3 counties of Shandong, China. Mean age of the participants was 15.0 (SD = 1.5) years, and 51% were boys. In November and December 2015, participants completed a structured questionnaire to assess sleep duration, sleep problems, behavioral/emotional problems, and hopelessness...
January 9, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325238/psychometrics-of-the-self-report-concise-associated-symptoms-tracking-scale-cast-sr-results-from-the-stride-ctn-0037-study
#9
Joseph M Trombello, Michael O Killian, Allen Liao, Katherine Sanchez, Tracy L Greer, Robrina Walker, Bruce Grannemann, Chad D Rethorst, Thomas Carmody, Madhukar H Trivedi
OBJECTIVE: The self-report Concise Associated Symptoms Tracking Scale (CAST-SR) was developed to track mania, irritability, anxiety, panic, and insomnia symptoms among depressed outpatients receiving antidepressant medication. Given the overlap between these domains, depression, and stimulant use disorders, we reexamined CAST-SR psychometrics in a novel sample: individuals with stimulant use disorder receiving aerobic exercise or health education interventions. METHODS: Using the subsample of stimulant-dependent (following DSM-IV criteria) individuals prescribed antidepressants (N = 124) from the multisite Stimulant Reduction Intervention Using Dosed Exercise (CTN-0037) trial (total sample N = 302), conducted July 2010 to February 2013, we analyzed CAST-SR data collected at the first assessment after participant's discharge from residential treatment...
January 9, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325236/treatment-with-a-ghrelin-agonist-in-outpatient-women-with-anorexia-nervosa-a-randomized-clinical-trial
#10
Pouneh K Fazeli, Elizabeth A Lawson, Alexander T Faje, Kamryn T Eddy, Hang Lee, Fred T Fiedorek, Anne Breggia, Ildiko M Gaal, Rebecca DeSanti, Anne Klibanski
OBJECTIVE: To assess the effects of relamorelin-an agonist of the appetite-stimulating hormone ghrelin, which has effects on gastric emptying-on (1) weight gain and (2) gastric emptying in women with anorexia nervosa. METHODS: In a randomized, double-blind, placebo-controlled design, the effects of the ghrelin agonist relamorelin were studied in 22 outpatient women with anorexia nervosa, diagnosed using DSM-5 criteria. The study was conducted at the Massachusetts General Hospital Clinical Research Center between March 11, 2013, and February 26, 2015...
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325235/taking-on-the-role-of-editor-in-chief
#11
Marlene P Freeman
No abstract text is available yet for this article.
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29325234/prospective-associations-between-infant-sleep-at-12-months-and-autism-spectrum-disorder-screening-scores-at-24-months-in-a-community-based-birth-cohort
#12
A K Danny Nguyen, Laura E Murphy, Mehmet Kocak, Frances A Tylavsky, Linda S Pagani
BACKGROUND: Sleep problems have been associated with autism spectrum disorder (ASD) symptoms and diagnosis. However, past research has studied the simultaneous association of sleep problems with precursor ASD symptoms. Using data from a birth cohort, we estimate prospective associations between infant sleep characteristics at 12 months and later ASD screening scores at 24 months. METHODS: We obtained data from children (N = 1,096) and their mothers as participants in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood longitudinal birth cohort study...
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29286595/galantamine-and-computerized-cognitive-behavioral-therapy-for-cocaine-dependence-a-randomized-clinical-trial
#13
Kathleen M Carroll, Charla Nich, Elise E DeVito, Julia M Shi, Mehmet Sofuoglu
OBJECTIVE: To examine whether galantamine, a cognitive-enhancing medication that is both acetylcholinesterase inhibitor and agonist at nicotinic acetylcholine receptors, is effective at improving cocaine use outcomes and cognitive functioning, alone and in combination with computerized cognitive behavioral therapy (CBT). METHOD: A 12-week, randomized 2 × 2, factorial trial was conducted to evaluate galantamine versus placebo (double-blind) and computerized CBT plus standard methadone treatment versus standard methadone treatment alone in a community-based methadone maintenance program (September 2009-April 2015)...
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29286594/circadian-rhythm-and-the-prediction-of-relapse-in-bipolar-disorder
#14
Robert Gonzalez, Mauricio Tohen
No abstract text is available yet for this article.
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29286593/circadian-rhythm-sleep-wake-disorders-predict-shorter-time-to-relapse-of-mood-episodes-in-euthymic-patients-with-bipolar-disorder-a-prospective-48-week-study
#15
Yoshikazu Takaesu, Yuichi Inoue, Kotaro Ono, Akiko Murakoshi, Kunihiro Futenma, Yoko Komada, Takeshi Inoue
OBJECTIVE: Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm dysfunction could be a predictor of relapse in euthymic BD patients. METHODS: One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), participated in this prospective follow-up study from August 2014 to April 2015...
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29286591/repeated-low-grade-infections-predict-antidepressant-resistant-depression-a-nationwide-population-based-cohort-study
#16
Jia-Shyun Jeng, Cheng-Ta Li, Mu-Hong Chen, Wei-Chen Lin, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Wen-Hang Chang, Yen-Jen Sung
BACKGROUND: The relationship between severe inflammation and clinical depression in the context of major medical illnesses has been addressed, but the relationship between inflammation caused by mild infections and clinical depression is unclear. We aimed to examine whether a history of repeated low-grade infections (RLGI) in medically healthy subjects (MHS) could increase their vulnerability to major depressive disorder (MDD) (ICD-9-CM) and whether RLGI could be associated with higher resistance to antidepressants in those developing MDD...
December 19, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29286590/the-association-between-sleep-apnea-and-suicidal-thought-and-behavior-an-analysis-of-national-survey-data
#17
Todd M Bishop, Lisham Ashrafioun, Wilfred R Pigeon
OBJECTIVE: Sleep disturbances have been associated with increased risk for suicidal thought and behavior. The literature in regard to sleep and suicide, however, has focused predominantly on generalized sleep disturbance or insomnia. The purpose of the current study is to examine relationships among sleep apnea and suicidal thought and behavior using a nationally representative sample. METHODS: We conducted a secondary analysis of 2014 data from the National Survey on Drug Use and Health...
December 19, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29244266/patients-with-alcohol-use-disorder-co-occurring-with-depression-and-anxiety-symptoms-diagnostic-and-treatment-initiation-recommendations
#18
Ahmed N Hassan
No abstract text is available yet for this article.
December 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29244265/herpes-zoster-and-dementia-a-nationwide-population-based-cohort-study
#19
Vincent Chin-Hung Chen, Shu-I Wu, Kuo-You Huang, Yao-Hsu Yang, Ting-Yu Kuo, Hsin-Yi Liang, Kuan-Lun Huang, Michael Gossop
OBJECTIVE: Some infectious diseases have been found to be associated with cognitive impairment and dementia. However, the relationship between herpes zoster and dementia has received little attention. This study aimed to investigate this association as well as associations of antiviral treatments for herpes zoster and incident dementia using a large national sample. METHODS: Cases were identified from the Taiwan National Health Insurance Research Database with a new diagnosis of herpes zoster (ICD-9-CM code: 053) between 1997 and 2013...
December 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29228518/childhood-trauma-is-associated-with-poorer-cognitive-performance-in-older-adults
#20
Andrew J Petkus, Eric J Lenze, Meryl A Butters, Elizabeth W Twamley, Julie Loebach Wetherell
OBJECTIVE: Childhood trauma is common and associated with both worse cognitive performance and disruption to the hypothalamic-pituitary-adrenal axis in younger adults. The extent to which these associations persist into older adulthood remains unknown. The aim of this study was to investigate self-reported childhood trauma in relation to cognitive performance, and the extent to which cortisol explained this association, in 2 independent samples of older adults. METHODS: In this cross-sectional study, participants in the discovery sample (N = 76) consisted of older adults with a DSM-IV diagnosis of generalized anxiety disorder (N = 57) and age-equated psychiatrically healthy comparison subjects (N = 19) who were referred largely through primary care clinics between 2004-2006...
December 5, 2017: Journal of Clinical Psychiatry
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