journal
MENU ▼
Read by QxMD icon Read
search

Journal of Clinical Psychiatry

journal
https://www.readbyqxmd.com/read/29659208/posttraumatic-stress-disorder-as-a-significant-correlate-of-voluntary-antiretroviral-treatment-interruption-in-adult-hiv-infected-patients-followed-up-in-french-hospitals-data-from-the-anrs-vespa2-national-survey
#1
Perrine Roux, Fabienne Marcellin, Khadim Ndiaye, Marie Suzan-Monti, Aurélie Mayet, Martin Duracinsky, Laélia Briand-Madrid, Gwenaëlle Maradan, Marion Mora, Marie Préau, Pierre Verger, Patrizia Carrieri, Rosemary Dray-Spira, Bruno Spire
OBJECTIVE: Although antiretroviral treatment (ART) no longer requires 100% adherence, voluntary treatment interruption (VTI) still may have a negative impact on virologic success. Previous studies have shown that posttraumatic stress disorder (PTSD) is more prevalent in HIV-infected patients than in the general population. However, no study has yet investigated the relationship between PTSD and VTI. We analyzed this relationship using data from a French national survey representative of HIV-infected adults followed up in hospitals...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659207/trajectories-of-acute-antidepressant-efficacy-how-long-to-wait-for-response-a-systematic-review-and-meta-analysis-of-long-term-placebo-controlled-acute-treatment-trials
#2
Jonathan Henssler, Mona Kurschus, Jeremy Franklin, Tom Bschor, Christopher Baethge
BACKGROUND: In patients who are not responding to antidepressant pharmacotherapy, information regarding the future probability of response with the same treatment is scarce. Specifically, it is unclear at what point in time the probability to respond or remit ceases to increase, because few studies report data on response or remission at repeated time points beyond 4 or 8 weeks of treatment. Consequently, treatment recommendations in clinical practice guidelines differ widely. DATA SOURCES: We systematically searched MEDLINE, Embase, PsycINFO, and CENTRAL databases through March 2014 using generic terms for depressive or affective disorders, individual drug names, and placebo (Prospero Registration: CRD42014010105)...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659206/effects-of-antipsychotics-on-secular-mortality-trends-in-patients-with-alzheimer-s-disease
#3
René Ernst Nielsen, Jan B Valentin, Annette Lolk, Kjeld Andersen
OBJECTIVE: To investigate secular changes in mortality rates between patients with Alzheimer's disease (AD) and the general population as well as changes in antipsychotic drug treatment and the association between drug treatment and mortality in patients with AD in Denmark during a 12-year study period. METHODS: This nationwide, retrospective cohort study identified all-cause mortality in all Danish patients with incident ICD-10-defined AD from 2000 through 2011...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659205/executive-function-predicts-antidepressant-treatment-noncompletion-in-late-life-depression
#4
Pilar Cristancho, Eric J Lenze, David Dixon, J Philip Miller, Benoit H Mulsant, Charles F Reynolds, Meryl A Butters
OBJECTIVE: To examine whether executive function (EF) is associated with nonremission and noncompletion of antidepressant pharmacotherapy in older adults with depression. DESIGN: In this prospective study (July 2009 to May 2014), older adults (aged ≥ 60 years; n = 468) with a DSM-IV-defined major depressive episode diagnosed via structured interview received 12 weeks of venlafaxine extended release with the goal of achieving remission. A hypothesis was made that worse baseline EF would predict both nonremission and noncompletion (primary outcomes)...
April 3, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659211/ketamine-for-depression-6-effects-on-suicidal-ideation-and-possible-use-as-crisis-intervention-in-patients-at-suicide-risk
#5
Chittaranjan Andrade
A growing body of literature suggests that ketamine, administered in subanesthetic doses, has early-onset antidepressant action in patients with severe and even treatment-refractory depression. Many case reports, open-label studies, and randomized controlled trials (RCTs) suggest that ketamine may have dramatic antisuicidal effects, as well. This article examines the benefits of ketamine in patients with suicidal ideation with particular focus on the findings of recent RCTs and meta-analyses. Important findings are that a single dose of ketamine is associated with antisuicidal benefits that emerge within an hour of administration and persist for up to a week...
March 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659210/toward-understanding-sex-differences-in-the-prevalence-of-posttraumatic-stress-disorder-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions
#6
Carlos Blanco, Nicolas Hoertel, Melanie M Wall, Silvia Franco, Hugo Peyre, Yuval Neria, Liat Helpman, Frédéric Limosin
BACKGROUND: It is unclear whether the higher prevalence of posttraumatic stress disorder (PTSD) in women than in men is due to sex differences in the prevalence of the exposure to traumatic events or to differences in vulnerability to traumatic events among those exposed to them. METHODS: We applied mediation and moderated mediation models to a large nationally representative sample of US adults (N = 34,653) drawn from Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions...
March 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29659209/improving-the-diagnosis-and-treatment-of-pediatric-bipolar-disorder
#7
Robert L Findling, Kiki D Chang
​​Reconsidering Insomnia as a Disorder Rather Than Just a Symptom in Psychiatric Practice Click to enlarge page Awareness of the prevalence and impact of bipolar disorder in pediatric patients has grown in recent years. Youths with this disorder are at risk for poor long-term outcomes, but with careful screening, clinicians may be able to detect early signs or subthreshold symptoms and provide a timely diagnosis and effective treatment. Although several pharmacologic options are available for patients aged 10 years and up, they differ in their safety and tolerability profiles...
March 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29570971/phenotypic-assessment-of-drug-metabolic-pathways-and-p-glycoprotein-in-patients-treated-with-antidepressants-in-an-ambulatory-setting
#8
Célia Lloret-Linares, Marija Bosilkovska, Youssef Daali, Marianne Gex-Fabry, Kyle Heron, Victor Bancila, Giorgio Michalopoulos, Nader Perroud, Hélène Richard-Lepouriel, Jean-Michel Aubry, Jules Desmeules, Marie Besson
OBJECTIVE: Drug-metabolizing enzymes (DMEs), such as cytochrome P450 (CYP) enzymes, and transporters have emerged as major determinants of variability in drug metabolism and response. This study investigated the association between CYP and P-glycoprotein activities and plasma antidepressant concentration in an outpatient clinical setting. Secondary outcomes were antidepressant efficacy and tolerance. We also describe phenotypes in patients treated with antidepressants and evaluate the tolerance of a minimally invasive phenotyping approach...
March 20, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29570970/sources-of-prescription-medication-misuse-among-young-adults-in-the-united-states-the-role-of-educational-status
#9
Sean Esteban McCabe, Christian J Teter, Carol J Boyd, Timothy E Wilens, Ty S Schepis
OBJECTIVE: This study examined prescription drug misuse (PDM), sources of PDM, and substance use disorder (SUD) symptoms as a function of educational status among US young adults based on a large nationally representative sample. METHODS: Data from the 2009-2014 National Survey on Drug Use and Health came from a sample of 106,845 young adults aged 18-25 years. Respondents were categorized by educational status and PDM, sources of PDM, other substance use, and SUD symptoms, with analyses performed separately for prescription opioids, stimulants, and sedatives/tranquilizers...
March 20, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29570969/tardive-dyskinesia-recognition-patient-assessment-and-differential-diagnosis
#10
Rakesh Jain, Christoph U Correll
Tardive dyskinesia (TD) is an involuntary movement disorder associated with antipsychotic treatment. Because of the serious and potentially irreversible nature of TD, accurate diagnosis is crucial. However, diagnosing TD can be challenging, since the subtle and often fluctuating symptoms can be easily mistaken for symptoms of mental illness or other side effects. Although the risk of developing TD in relation to treatment with second-generation antipsychotics is lower than that associated with first-generation antipsychotics, the risk still exists and may be greater than once believed...
March 20, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29617066/the-mixed-opioid-receptor-antagonist-naltrexone-mitigates-stimulant-induced-euphoria-a-double-blind-placebo-controlled-trial-of-naltrexone
#11
Thomas J Spencer, Pradeep Bhide, Jinmin Zhu, Stephen V Faraone, Maura Fitzgerald, Amy M Yule, Mai Uchida, Andrea E Spencer, Anna M Hall, Ariana J Koster, Leah Feinberg, Sarah Kassabian, Barbara Storch, Joseph Biederman
OBJECTIVE: Supratherapeutic doses of methylphenidate activate μ-opioid receptors, which are linked to euphoria. This study assessed whether naltrexone, a mixed μ-opioid antagonist, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential in subjects with attention-deficit/hyperactivity disorder (ADHD). METHODS: We conducted a 6-week, double-blind, placebo-controlled, randomized clinical trial of naltrexone in adults with DSM-IV ADHD receiving open treatment with a long-acting formulation of methylphenidate (January 2013 to June 2015)...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29617065/relationships-between-self-injurious-behaviors-pain-reactivity-and-%C3%AE-endorphin-in-children-and-adolescents-with-autism
#12
Sylvie Tordjman, George M Anderson, Annaëlle Charrier, Cécile Oriol, Solenn Kermarrec, Roberto Canitano, Michel Botbol, Nathalie Coulon, Corinne Antoine, Sylvie Brailly-Tabard, David Cohen, Hazar Haidar, Séverine Trabado, Michèle Carlier, Guillaume Bronsard, Laurent Mottron
OBJECTIVE: Autism and certain associated behaviors including self-injurious behaviors (SIB) and atypical pain reactivity have been hypothesized to result from excessive opioid activity. The objective of this study was to examine the relationships between SIB, pain reactivity, and β-endorphin levels in autism. METHODS: Study participants were recruited between 2007 and 2012 from day care centers and included 74 children and adolescents diagnosed with autism (according to DSM-IV-TR, ICD-10, and CFTMEA) and intellectual disability...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29617064/treatment-of-complicated-grief-in-survivors-of-suicide-loss-a-heal-report
#13
Sidney Zisook, M Katherine Shear, Charles F Reynolds, Naomi M Simon, Christine Mauro, Natalia A Skritskaya, Barry Lebowitz, Yuanjia Wang, Ilanit Tal, Danielle Glorioso, Julie Loebach Wetherell, Alana Iglewicz, Donald Robinaugh, Xin Qiu
OBJECTIVE: Suffering associated with complicated grief (CG) is profound. Because suicide loss survivors are susceptible to developing CG, identifying effective treatments for suicide loss survivors with CG is a high priority. This report provides data on the acceptability and effectiveness of antidepressant medication and complicated grief therapy (CGT), a CG-targeted psychotherapy, for suicide loss survivors with CG identified by an Inventory of Complicated Grief score ≥ 30. METHODS: This is a secondary analysis of data collected from March 2010 to September 2014 for a 4-site, double-blind, placebo-controlled randomized trial comparing the effectiveness of antidepressant medication alone or in combination with CGT for participants with CG (score ≥ 30 on the Inventory of Complicated Grief) who were bereaved by suicide (SB; n = 58), accident/homicide (A/H; n = 74), or natural causes (NC; n = 263)...
March 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29570966/is-cannabis-use-associated-with-increased-risk-of-cigarette-smoking-initiation-persistence-and-relapse-longitudinal-data-from-a-representative-sample-of-us-adults
#14
Andrea H Weinberger, Jonathan Platt, Jan Copeland, Renee D Goodwin
OBJECTIVE: The current study prospectively investigated the relationship between cannabis use and cigarette smoking initiation, persistence, and relapse during a 3-year period among adults in the United States. METHODS: Analyses included respondents who completed Waves 1 (2001-2002) and 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions and responded to questions about cannabis use and smoking status (n = 34,639). Multivariable logistic regression models were used to calculate the odds of cigarette use at Wave 2 among Wave 1 daily smokers, nondaily smokers, former smokers, and nonsmokers by Wave 1 cannabis use...
March 6, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29570965/can-aripiprazole-worsen-psychosis-in-schizophrenia-a-meta-analysis-of-double-blind-randomized-controlled-trials
#15
Hiroyoshi Takeuchi, Ali Fathi, Sadhana Thiyanavadivel, Ofer Agid, Gary Remington
BACKGROUND: Numerous case reports have reported psychotic worsening when switching to or adding aripiprazole in patients with schizophrenia. The risk of psychotic worsening related to aripiprazole was evaluated through a systematic review and meta-analysis. DATA SOURCES: MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were systematically searched using the following keywords: (schizophr* or schizoaff*) AND aripiprazole, with a limitation of randomized controlled trial and English language (last search: September 9, 2016) by the authors in an independent fashion...
March 6, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29570964/motivational-interviewing-overcoming-disparities-in-pharmacotherapy-engagement
#16
Roberto Lewis-Fernández, Angela A Coombs, Iván C Balán, Alejandro Interian
No abstract text is available yet for this article.
March 6, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29489078/sluggish-cognitive-tempo-as-a-possible-predictor-of-methylphenidate-response-in-children-with-adhd-a-randomized-controlled-trial
#17
Tanya E Froehlich, Stephen P Becker, Todd G Nick, William B Brinkman, Mark A Stein, James Peugh, Jeffery N Epstein
OBJECTIVE: To examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects. METHODS: Stimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate...
February 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29489077/inflammation-and-improvement-of-depression-following-electroconvulsive-therapy-in-treatment-resistant-depression
#18
Jennifer L Kruse, Eliza Congdon, Richard Olmstead, Stephanie Njau, Elizabeth C Breen, Katherine L Narr, Randall Espinoza, Michael R Irwin
OBJECTIVE: Electroconvulsive therapy (ECT) is the most robust acute treatment for severe major depressive disorder, yet clinical response is variable. Inflammation is associated with depression, especially in women, and levels of C-reactive protein (CRP) and interleukin (IL)-6 predict response to antidepressant medications. This study evaluated whether markers of inflammation predicted response to electroconvulsive therapy (ECT) in patients with treatment-resistant depression and to what extent this association differed between men and women...
February 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29489076/pathways-to-late-life-suicidal-behavior-cluster-analysis-and-predictive-validation-of-suicidal-behavior-in-a-sample-of-older-adults-with-major-depression
#19
Katalin Szanto, Hanga Galfalvy, Polina M Vanyukov, John G Keilp, Alexandre Y Dombrovski
OBJECTIVE: Clinical heterogeneity is a key challenge to understanding suicidal risk, as different pathways to suicidal behavior are likely to exist. We aimed to identify such pathways by uncovering latent classes of late-life depression cases and relating them to prior and future suicidal behavior. METHODS: Data were collected from June 2010 to September 2015. In this longitudinal study we examined distinct associations of clinical and cognitive/decision-making factors with suicidal behavior in 194 older (50+ years) nondemented, depressed patients; 57 nonpsychiatric healthy controls provided benchmark data...
February 27, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29474009/direct-and-indirect-cost-burden-and-change-of-employment-status-in-treatment-resistant-depression-a-matched-cohort-study-using-a-us-commercial-claims-database
#20
Tony B Amos, Neeta Tandon, Patrick Lefebvre, Dominic Pilon, Rhiannon L Kamstra, Irina Pivneva, Paul E Greenberg
BACKGROUND: Treatment-resistant depression (TRD) poses a substantial burden to health care payers including employers, costing an estimated $29 billion-$48 billion yearly in the United States. Furthermore, variation of burden across increasing levels of resistance and the potential impact of TRD on employment status remain largely unexplored. OBJECTIVE: To evaluate health care resource utilization (HRU) and costs, work loss, indirect costs, and employment status change in TRD...
February 20, 2018: Journal of Clinical Psychiatry
journal
journal
20147
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"