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Journal of Clinical Psychiatry

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https://www.readbyqxmd.com/read/29022655/anosognosia-is-an-independent-predictor-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-and-is-associated-with-reduced-brain-metabolism
#1
Philip Gerretsen, Jun Ku Chung, Parita Shah, Eric Plitman, Yusuke Iwata, Fernando Caravaggio, Shinichiro Nakajima, Bruce G Pollock, Ariel Graff-Guerrero
OBJECTIVE: Anosognosia, or impaired illness awareness, is a common feature of Alzheimer's disease (AD) and less so of mild cognitive impairment (MCI). Importantly, anosognosia negatively influences clinical outcomes for patients and their caregivers and may predict the conversion from MCI to AD. This study aimed to examine (1) the relationship between brain glucose metabolism as measured by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and anosognosia in patients with MCI and AD and (2) the predictive utility of anosognosia in patients with MCI for later conversion to AD, even when controlling for other factors, including gender, education, apolipoprotein E ε4 carrier status, dementia severity, and cognitive dysfunction...
October 10, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29022654/epidemiology-prevention-and-assessment-of-tardive-dyskinesia-and-advances-in-treatment
#2
Christoph U Correll, John M Kane, Leslie L Citrome
Tardive dyskinesia (TD) is a disorder characterized by involuntary movements, typically of the orofacial muscles and also of the extremities and other muscle groups. The condition is associated with exposure to dopamine receptor blocking agents, including antipsychotics. Because the indications and off-label uses for these agents have expanded over the last 2 decades, a larger number of patients are receiving antipsychotic medications than in the past. While evidence suggests that patients being treated with second-generation antipsychotics have less risk for developing TD than those treated with first-generation antipsychotics, the decreased risk is not as great as was originally expected...
October 10, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994517/the-impact-of-obesity-on-cognitive-functioning-in-euthymic-bipolar-patients-a-cross-sectional-and-longitudinal-study
#3
Ester Mora, Maria J Portella, Montserrat Martinez-Alonso, Montse Teres, Irene Forcada, Eduard Vieta, Maria Mur
OBJECTIVE: To determine the influence of body mass index (BMI) on cognition in euthymic bipolar patients and healthy matched controls in a post hoc study of 2 cross-sectional and longitudinal exploratory studies. METHOD: A total sample of 121 individuals was examined, which included 52 euthymic bipolar disorder I or II patients (DSM-IV-TR criteria) and 69 healthy controls matched by age and gender, categorized in 2 subgroups in terms of body mass index (BMI-factor): normal weight (BMI: 18...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994516/the-implication-of-combat-stress-and-ptsd-trajectories-in-metabolic-syndrome-and-elevated-c-reactive-protein-levels-a-longitudinal-study
#4
Zahava Solomon, Yafit Levin, Einor Ben Assayag, Orit Furman, Shani Shenhar-Tsarfaty, Shlomo Berliner, Avi Ohry
OBJECTIVE: This study sheds light on the importance of long-term follow-up of trauma survivors, posttraumatic stress disorder (PTSD) trajectories, and early detection of health risk factors in trauma survivors. The present study prospectively assessed the following over 23 years: (1) the association of psychological and physiologic stress during captivity with elevated C-reactive protein (CRP) levels and metabolic syndrome (MetS), which includes hypertension; elevated levels of insulin, triglycerides, and fasting glucose; decreased levels of high-density lipoprotein cholesterol; and obesity and (2) the implication of PTSD trajectories in elevated CRP levels and MetS...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994903/antidepressant-exposure-during-pregnancy-and-risk-of-autism-in-the-offspring-1-meta-review-of-meta-analyses
#5
Chittaranjan Andrade
There are no randomized controlled trials of antidepressant drugs to treat depression, or to prevent relapse into depression, during pregnancy; therefore, the safety of antidepressant drug exposure during pregnancy is based on evidence from case-control or cohort studies. Many of these observational studies, during the past decade, examined the risk of autism spectrum disorder (ASD) in exposed offspring. Different studies using different methods and examining different periods of antidepressant exposure before and during pregnancy obtained different results...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994902/corrected-qt-interval-and-methadone-dose-and-concentrations-in-pregnant-and-postpartum-women
#6
Debra L Bogen, Barbara H Hanusa, James M Perel, Frederick Sherman, Marla A Mendelson, Katherine L Wisner
BACKGROUND: Methadone is a standard treatment for opioid dependence in pregnancy; however, its impact on maternal corrected QT interval (QTc) has not been evaluated. We studied the association between methadone dose and enantiomer-specific plasma concentrations and QTc among pregnant and postpartum women and newborns. We assessed the relevance of QTc screening guidelines for pregnant women and infants. METHODS: From 2006 to 2008, plasma methadone concentrations were measured during pregnancy, postpartum, and in cord blood in women treated for opioid dependence at a single treatment program...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994901/risk-of-first-onset-stroke-in-ssri-exposed-adult-subjects-survival-analysis-and-examination-of-age-and-time-effects
#7
Chin-Hong Chan, Hsiang-Hsiung Huang, Ching-Heng Lin, Yi-Chun Kuan, El-Wui Loh, Tsuo-Hung Lan
OBJECTIVE: Exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to increase the risk of stroke. In this study, we investigated age and time effects on the risk of first onset stroke in SSRI-exposed (SSRIEXP) adult subjects. METHODS: We analyzed an 8-year cohort from the National Health Insurance Research Database, Taiwan. Patients were defined as SSRIEXP subjects if they received SSRI prescriptions for at least 2 consecutive months during January 1, 2001, to December 31, 2007...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28994900/diagnosing-and-treating-patients-with-mixed-features
#8
Rakesh Jain, Vladimir Maletic, Roger S McIntyre
No abstract text is available yet for this article.
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28937707/meta-analysis-of-the-antidepressant-effects-of-acute-sleep-deprivation
#9
Elaine M Boland, Hengyi Rao, David F Dinges, Rachel V Smith, Namni Goel, John A Detre, Mathias Basner, Yvette I Sheline, Michael E Thase, Philip R Gehrman
OBJECTIVE: To provide a quantitative meta-analysis of the antidepressant effects of sleep deprivation to complement qualitative reviews addressing response rates. DATA SOURCES: English-language studies from 1974 to 2016 using the keywords sleep deprivation and depression searched through PubMed and PsycINFO databases. STUDY SELECTION: A total of 66 independent studies met criteria for inclusion: conducted experimental sleep deprivation, reported the percentage of the sample that responded to sleep deprivation, provided a priori definition of antidepressant response, and did not seamlessly combine sleep deprivation with other therapies (eg, chronotherapeutics, repetitive transcranial magnetic stimulation)...
September 19, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28937706/durability-of-therapeutic-response-with-long-term-aripiprazole-lauroxil-treatment-following-successful-resolution-of-an-acute-episode-of-schizophrenia
#10
Joseph P McEvoy, Robert Risinger, Serhiy Mykhnyak, Yangchun Du, Chih-Chin Liu, Arielle D Stanford, Peter J Weiden
OBJECTIVE: To evaluate durability of therapeutic effect of long-term treatment with aripiprazole lauroxil in patients with schizophrenia following successful treatment of an acute psychotic episode. METHODS: This post hoc analysis assessed long-term outcomes for a subgroup of patients who entered a 52-week extension study after being successfully stabilized with one of 2 doses of aripiprazole lauroxil (441 or 882 mg) in a pivotal 12-week, placebo-controlled, randomized clinical trial...
September 19, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922590/efficacy-and-safety-of-the-%C3%AE-7-nicotinic-acetylcholine-receptor-agonist-abt-126-in-the-treatment-of-cognitive-impairment-associated-with-schizophrenia-results-from-a-phase-2b-randomized-controlled-study-in-smokers
#11
George M Haig, Deli Wang, Jun Zhao, Ahmed A Othman, Earle E Bain
OBJECTIVE: To evaluate the efficacy and safety of the α₇-nicotinic receptor agonist ABT-126 for treatment of cognitive impairment in stable subjects with schizophrenia who smoke. METHODS: A 12-week double-blind, placebo-controlled, parallel-group study was conducted from August 2012 to March 2014. Subjects with a diagnosis of schizophrenia based on DSM-IV-TR criteria (confirmed by the Mini-International Neuropsychiatric Interview version 6.0.0) were randomized 1:1:1 to ABT-126 25 mg, ABT-126 75 mg, or placebo once daily while maintained on their background antipsychotic medication...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922589/higher-baseline-proinflammatory-cytokines-mark-poor-antidepressant-response-in-bipolar-disorder
#12
Francesco Benedetti, Sara Poletti, Thomas A Hoogenboezem, Clara Locatelli, Harm de Wit, Annemarie J M Wijkhuijs, Cristina Colombo, Hemmo A Drexhage
BACKGROUND: The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response. METHODS: We studied at baseline 15 immune-regulating compounds in 37 consecutively admitted inpatients with a major depressive episode in the course of bipolar disorder (DSM-5 criteria) and in 24 controls...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#13
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922592/determining-if-borderline-personality-disorder-and-bipolar-disorder-are-alternative-expressions-of-the-same-disorder-results-from-the-national-epidemiologic-survey-on-alcohol-and-related-conditions
#14
Iris de la Rosa, María A Oquendo, Gemma García, Barbara Stanley, Ana González-Pinto, Shang-Min Liu, Carlos Blanco
OBJECTIVE: To examine whether bipolar disorder and borderline personality disorder represent 2 different disorders or alternative manifestations of the same disorder. METHODS: The data were collected between January 1, 2004, and December 31, 2005. The analyses were conducted between December 21 and December 27, 2010. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed on 25 symptoms assessing depression, mania, and borderline personality disorder from the National Epidemiologic Survey on Alcohol and Related Conditions, a large nationally representative sample of the US adult population (N = 34,653)...
September 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28922591/baseline-characteristics-and-early-response-at-week-1-predict-treatment-outcome-in-adolescents-with-bipolar-manic-or-mixed-episode-treated-with-olanzapine-results-from-a-3-week-randomized-placebo-controlled-trial
#15
Le Xiao, Stephen J Ganocy, Robert L Findling, Kiki Chang, Melissa P DelBello, John M Kane, Mauricio Tohen, Yu-Tao Xiang, Christoph U Correll
BACKGROUND: Early predictors of response and remission in pediatric mania are lacking, requiring further study. METHODS: This was a post hoc analysis of a 3-week, randomized, placebo-controlled trial of olanzapine conducted between November 2002 and May 2005 in 161 adolescents aged 13-17 years who were diagnosed with a DSM-IV acute manic or mixed episode of bipolar I disorder. Data from the olanzapine arm were analyzed to investigate the predictive power of early response or early nonresponse (≥25% or < 25% reduction in Young Mania Rating Scale [YMRS] score, respectively) at week 1 for ultimate response or nonresponse (≥ 50% or < 50% reduction in YMRS score, respectively) and for remission (YMRS total score ≤ 12 [standard definition] or ≤ 8 [stringent definition]) at week 3...
September 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28872268/risk-of-suicide-attempts-among-adolescents-and-young-adults-with-autism-spectrum-disorder-a-nationwide-longitudinal-follow-up-study
#16
Mu-Hong Chen, Tai-Long Pan, Wen-Hsuan Lan, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Han-Ting Wei, Tzeng-Ji Chen, Ya-Mei Bai
BACKGROUND: Previous studies reported a high prevalence of depression among patients with autism spectrum disorder (ASD) and suggested a relationship between ASD and suicidality. However, whether ASD independently increases the risk of attempted suicide regardless of depression has not been determined. METHODS: Using the Taiwan National Health Insurance Research Database, 5,618 adolescents aged 12-17 years and young adults aged 18-29 years with ASD (ICD-9-CM code: 299) and 22,472 age- and sex-matched controls were enrolled between 2001 and 2009 and followed to the end of 2011...
August 29, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28872267/psychological-pain-in-suicidality-a-meta-analysis
#17
Déborah Ducasse, Ronald R Holden, Laurent Boyer, Sylvaine Artéro, Raffaella Calati, Sébastien Guillaume, Philippe Courtet, Emilie Olié
OBJECTIVE: Perform a meta-analysis to quantify the association between psychological pain and current or lifetime history of suicidal ideation or suicide attempt. DATA SOURCES: Search MEDLINE, Web of Science, and PsycINFO from 1965 to 2015 for (psychache OR mental pain OR psychological pain) AND (suicid*). STUDY SELECTION: Observational case-control studies addressing the difference in psychological pain between individuals with and without current or lifetime history of suicidal ideation or suicide attempt...
August 29, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28837274/association-between-bone-mineral-density-and-depressive-symptoms-in-a-population-based-sample
#18
Rocco D Hlis, Roger S McIntyre, Naim M Maalouf, Erin Van Enkevort, E Sherwood Brown
OBJECTIVE: This analysis was conducted to determine the relationship between bone mineral density (BMD) and depressive symptoms in a population-based cohort. METHODS: Data were extracted from the second phase of the Dallas Heart Study (DHS-2), a large, multiethnic population sample in Dallas County, Texas, from September 1, 2007, to December 31, 2009. Depressive symptom severity was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR₁₆), which is derived from DSM-IV major depressive disorder criteria...
August 22, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28817765/preventive-effects-of-lamotrigine-in-bipolar-ii-versus-bipolar-i-disorder
#19
Takeshi Terao, Atsuko Ishida, Toshifumi Kimura, Masao Yarita, Terufumi Hara
OBJECTIVE: The preventive effects of mood stabilizers on recurrence/relapse in bipolar disorders have been investigated mostly in bipolar I disorder (BPI) patients, with limited reports on bipolar II disorder (BPII) patients. Here, we conducted an explorative data analysis to investigate whether the preventive effect of lamotrigine on recurrence /relapse in BPII is better than in BPI. METHODS: Data from Japanese patients with a diagnosis of BPI or BPII according to DSM-IV-TR were analyzed in an open-label, noninterventional, naturalistic, prospective postmarketing surveillance study of lamotrigine...
August 15, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28817764/limited-functioning-after-remission-of-an-anxiety-disorder-as-a-trait-effect-versus-a-scar-effect-results-of-a-longitudinal-general-population-study
#20
Simone M E Schopman, Margreet Ten Have, Saskia van Dorsselaer, Ron de Graaf, Neeltje M Batelaan
OBJECTIVE: After remission of an anxiety disorder, subjects often experience persistent functional impairments. We examined whether impairments in mental and physical functioning following remission are a continuation of premorbid lower functioning (trait effect), due to impairments that develop during the anxiety disorder and persist beyond recovery (scar effect), or both. METHODS: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a prospective psychiatric epidemiologic study among the general population with a 3-wave design (6-year follow-up, with the study starting in 2007 and ending in 2015)...
August 15, 2017: Journal of Clinical Psychiatry
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