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Journal of Clinical Psychiatry

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https://www.readbyqxmd.com/read/29244266/patients-with-alcohol-use-disorder-co-occurring-with-depression-and-anxiety-symptoms-diagnostic-and-treatment-initiation-recommendations
#1
Ahmed N Hassan
No abstract text is available yet for this article.
December 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29244265/herpes-zoster-and-dementia-a-nationwide-population-based-cohort-study
#2
Vincent Chin-Hung Chen, Shu-I Wu, Kuo-You Huang, Yao-Hsu Yang, Ting-Yu Kuo, Hsin-Yi Liang, Kuan-Lun Huang, Michael Gossop
OBJECTIVE: Some infectious diseases have been found to be associated with cognitive impairment and dementia. However, the relationship between herpes zoster and dementia has received little attention. This study aimed to investigate this association as well as associations of antiviral treatments for herpes zoster and incident dementia using a large national sample. METHODS: Cases were identified from the Taiwan National Health Insurance Research Database with a new diagnosis of herpes zoster (ICD-9-CM code: 053) between 1997 and 2013...
December 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29228518/childhood-trauma-is-associated-with-poorer-cognitive-performance-in-older-adults
#3
Andrew J Petkus, Eric J Lenze, Meryl A Butters, Elizabeth W Twamley, Julie Loebach Wetherell
OBJECTIVE: Childhood trauma is common and associated with both worse cognitive performance and disruption to the hypothalamic-pituitary-adrenal axis in younger adults. The extent to which these associations persist into older adulthood remains unknown. The aim of this study was to investigate self-reported childhood trauma in relation to cognitive performance, and the extent to which cortisol explained this association, in 2 independent samples of older adults. METHODS: In this cross-sectional study, participants in the discovery sample (N = 76) consisted of older adults with a DSM-IV diagnosis of generalized anxiety disorder (N = 57) and age-equated psychiatrically healthy comparison subjects (N = 19) who were referred largely through primary care clinics between 2004-2006...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29228517/cost-effectiveness-of-internet-based-cognitive-behavioral-treatment-for-bulimia-nervosa-results-of-a-randomized-controlled-trial
#4
Hunna J Watson, Nicole McLagan, Stephanie C Zerwas, Ross D Crosby, Michele D Levine, Cristin D Runfola, Christine M Peat, Markus Moessner, Benjamin Zimmer, Sara M Hofmeier, Robert M Hamer, Marsha D Marcus, Cynthia M Bulik, Scott J Crow
OBJECTIVE: To evaluate the cost-effectiveness of Internet-based cognitive-behavioral therapy for bulimia nervosa (CBT-BN) compared to face-to-face delivery of CBT-BN. METHODS: This study is a planned secondary analysis of data from a randomized clinical trial. Participants were 179 adults (98% female, mean age = 28 years) meeting DSM-IV criteria for bulimia nervosa who were randomized to group face-to-face or group Internet-based CBT-BN for 16 sessions during 20 weeks...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29228516/refining-prediction-in-treatment-resistant-depression-results-of-machine-learning-analyses-in-the-trd-iii-sample
#5
Alexander Kautzky, Markus Dold, Lucie Bartova, Marie Spies, Thomas Vanicek, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Joseph Zohar, Chiara Fabbri, Alessandro Serretti, Rupert Lanzenberger, Siegfried Kasper
OBJECTIVE: The study objective was to generate a prediction model for treatment-resistant depression (TRD) using machine learning featuring a large set of 47 clinical and sociodemographic predictors of treatment outcome. METHOD: 552 Patients diagnosed with major depressive disorder (MDD) according to DSM-IV criteria were enrolled between 2011 and 2016. TRD was defined as failure to reach response to antidepressant treatment, characterized by a Montgomery-Asberg Depression Rating Scale (MADRS) score below 22 after at least 2 antidepressant trials of adequate length and dosage were administered...
December 5, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29188908/anticholinergic-burden-and-cognition-in-older-patients-with-schizophrenia
#6
Christopher Tsoutsoulas, Benoit H Mulsant, Sanjeev Kumar, Zaid Ghazala, Aristotle N Voineskos, Mahesh Menon, Bruce G Pollock, Tarek K Rajji
OBJECTIVE: Older individuals with schizophrenia are at risk of being treated with anticholinergic medications due to the prevalence of medical comorbidities and polypharmacy. High anticholinergic burden impairs cognition and is a risk factor for Alzheimer's dementia. Thus, we assessed the impact of anticholinergic burden on Alzheimer's dementia-related and schizophrenia-related cognitive functions in older patients with schizophrenia. METHODS: Anticholinergic burden was measured using the Anticholinergic Cognitive Burden scale (ACB) in 60 community-dwelling patients aged ≥ 50 years who met DSM-IV criteria for schizophrenia between May 2007 and November 2011...
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29188907/prescribing-patterns-in-a-psychiatrically-referred-sample-of-youth-with-autism-spectrum-disorder
#7
Julia Shekunov, Janet Wozniak, Kristina Conroy, Elizabeth Pinsky, Maura Fitzgerald, Melissa F de Leon, Abigail Belser, Joseph Biederman, Gagan Joshi
OBJECTIVE: The aim of this study was to examine the pattern of psychopharmacologic interventions in a psychiatrically referred sample of youth with autism spectrum disorder (ASD). METHODS: This retrospective chart review aimed at collecting demographic and clinical information, including data on DSM-IV-TR criteria-based psychiatric disorders and related current medication treatment and response. Data were collected in December 2011. Clinicians identified the target disorder for each medication and any adverse events...
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29188906/is-psychiatric-epidemiology-still-counting
#8
Myrna M Weissman
No abstract text is available yet for this article.
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29188905/review-and-meta-analysis-of-epidemiologic-studies-of-adult-bipolar-disorder
#9
Ana Lúcia R Moreira, Anna Van Meter, Jacquelynne Genzlinger, Eric A Youngstrom
OBJECTIVE: To test whether rates of bipolar disorder (BD) have changed over time or vary across geographic regions after adjusting for design features meta-analyzing epidemiologic studies reporting BD prevalence in adults worldwide. DATA SOURCES: Searches in PubMed and PsycINFO using the terms (epidemiology OR community OR prevalence) AND (mania OR "bipolar disorder" OR cyclothymi*) AND adult and backward searches from published reviews were conducted. STUDY SELECTION: Eighty-five epidemiologic studies published in English from 1980 onward that reported prevalence rates for BD or mania for subjects ≥ 18 years old were included...
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29188904/utilizing-the-dsm-5-anxious-distress-specifier-to-develop-treatment-strategies-for-patients-with-major-depressive-disorder
#10
(no author information available yet)
No abstract text is available yet for this article.
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29178686/memantine-as-an-augmentation-treatment-for-schizophrenia-limitations-of-meta-analysis-for-evidence-based-evaluation-of-research
#11
Chittaranjan Andrade
The action of memantine on N-methyl-D-aspartate (NMDA) glutamatergic receptors and the other pharmacodynamic actions of this drug suggest that it may benefit patients with schizophrenia. Many randomized controlled trials (RCTs) have examined this possibility. These RCTs have been meta-analyzed by at least 2 groups of authors. In one meta-analysis (8 RCTs, pooled N = 448), memantine (20 mg/d for 6-12 weeks) augmentation of antipsychotic drug therapy was found to attenuate the severity of negative symptoms and improve cognitive functioning; in both regards, the effect was large...
November 21, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29178685/clinical-and-genetic-predictors-of-delayed-remission-after-multiple-levels-of-antidepressant-treatment-toward-early-identification-of-depressed-individuals-for-advanced-care-options
#12
Michael I Falola, Nita Limdi, Richard C Shelton
OBJECTIVE: To identify clinical and genetic characteristics that can be used to recognize depressed patients who are likely to respond quickly versus those who will have a more delayed response following multiple treatment trials. METHODS: The data used were obtained from the National Institute of Mental Health-sponsored Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, which was conducted between July 2001 and September 2006. Of the 4,041 treatment-naive participants in the original study, 1,953 with DNA samples were included...
November 21, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29178684/a-supervised-exercise-intervention-for-youth-at-risk-for-psychosis-an-open-label-pilot-study
#13
Derek J Dean, Angela D Bryan, Raeana Newberry, Tina Gupta, Emily Carol, Vijay A Mittal
OBJECTIVE: A rapidly accumulating body of research suggests that exercise can improve symptoms and well-being in patients suffering from psychosis. Exercise may also promote neurogenesis in the hippocampus, a structure that plays an important role in the pathophysiology of psychosis. To date, there has not been an intervention focused on exercise prior to the onset of psychosis, a critical time for prevention of more serious illness. METHODS: In this pilot study, 12 young adults at ultrahigh risk (UHR) for psychosis were enrolled in a 12-week open-label exercise intervention...
November 21, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29178683/reducing-anticholinergic-medication-burden-in-patients-with-psychotic-or-bipolar-disorders
#14
Ana M Lupu, Kimberly Clinebell, Jessica M Gannon, Justin C Ellison, K N Roy Chengappa
OBJECTIVE: Anticholinergic medications are prescribed to treat extrapyramidal side effects (EPS) associated with antipsychotics. Anticholinergic medications cause several side effects and can often be withdrawn during the maintenance phase of antipsychotic treatment without EPS reemergence. The purpose of this quality improvement (QI) project was to reduce anticholinergic medication burden and improve quality of life in patients with severe mental illness. METHODS: Patients with DSM-IV-TR-diagnosed schizophrenia, schizoaffective disorder, and bipolar disorders in an outpatient psychiatric clinic who were prescribed benztropine were identified, screened for anticholinergic side effects by the treating psychiatrist, and referred to an on-site clinical pharmacist for a comprehensive medication review...
November 21, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29141125/elevated-proinflammatory-markers-in-22q11-2-deletion-syndrome-are-associated-with-psychosis-and-cognitive-deficits
#15
Ehud Mekori-Domachevsky, Michal Taler, Yehuda Shoenfeld, Michael Gurevich, Polina Sonis, Omri Weisman, Abraham Weizman, Doron Gothelf
OBJECTIVE: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder whose phenotype includes high rates of a schizophrenia-like psychotic disorder and immune system abnormalities. Thus, 22q11.2DS is an ideal model for studying the relationship between psychosis and inflammation. The aim of the present study was to identify inflammatory markers that may play a role in the pathophysiologic pathways associated with psychosis and cognitive deficits in 22q11.2DS. METHODS: Forty-nine individuals with 22q11...
November 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29141124/the-effects-of-valbenazine-in-participants-with-tardive-dyskinesia-results-of-the-1-year-kinect-3-extension-study
#16
Stewart A Factor, Gary Remington, Cynthia L Comella, Christoph U Correll, Joshua Burke, Roland Jimenez, Grace S Liang, Christopher F O'Brien
BACKGROUND: Valbenazine, a highly selective vesicular monoamine transporter 2 inhibitor, is approved for the treatment of tardive dyskinesia. This is the first report of long-term effects in adults with tardive dyskinesia. METHODS: Participants with a DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or a mood disorder who completed the 6-week, double-blind, placebo-controlled period of KINECT 3 were eligible to enter the 42-week valbenazine extension (VE) period and subsequent 4-week washout period...
November 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29125722/management-of-new-onset-psychosis-in-the-postpartum-period
#17
Amanda Tinkelman, Emily A Hill, Kristina M Deligiannidis
No abstract text is available yet for this article.
November 7, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29125721/the-association-between-comorbid-autism-spectrum-disorders-and-antipsychotic-treatment-failure-in-early-onset-psychosis-a-historical-cohort-study-using-electronic-health-records
#18
Johnny M Downs, Suzannah Lechler, Harry Dean, Nicola Sears, Rashmi Patel, Hitesh Shetty, Emily Simonoff, Matthew Hotopf, Tamsin J Ford, Covadonga M Diaz-Caneja, Celso Arango, James H MacCabe, Richard D Hayes, Laura Pina-Camacho
OBJECTIVE: In a sample of children and adolescents with first-episode psychosis, we investigated whether multiple treatment failure (MTF, defined as the initiation of a third trial of novel antipsychotic due to nonadherence, adverse effects, or insufficient response) was associated with comorbid autism spectrum disorders. METHODS: Data were from the electronic health records of 638 children (51% male) aged from 10 to 17 years with first-episode psychosis (per ICD-10 criteria) from January 1, 2008, to November 1, 2014, referred to mental health services in South London, United Kingdom; data were extracted using the Clinical Record Interactive Search (CRIS) system...
November 7, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29099547/treating-pediatric-anxiety-initial-use-of-ssris-and-other-antianxiety-prescription-medications
#19
Greta A Bushnell, Scott N Compton, Stacie B Dusetzina, Bradley N Gaynes, M Alan Brookhart, John T Walkup, Moira A Rynn, Til Stürmer
OBJECTIVE: Multiple pharmacotherapies for treating anxiety disorders exist, including selective serotonin reuptake inhibitors (SSRIs), the recommended first-line pharmacotherapy for pediatric anxiety. We sought to describe initial antianxiety medication use in children and estimate how long antianxiety medications were continued. METHODS: In a large commercial claims database, we identified children (3-17 years) initiating prescription antianxiety medication from 2004 to 2014 with a recent anxiety diagnosis (ICD-9-CM = 293...
October 31, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29099546/the-diagnostic-challenge-of-the-late-onset-frontal-lobe-syndrome-clinical-predictors-for-primary-psychiatric-disorders-versus-behavioral-variant-frontotemporal-dementia
#20
Everard G B Vijverberg, Flora Gossink, Welmoed Krudop, Sietske Sikkes, Cora Kerssens, Niels Prins, Max Stek, Philip Scheltens, Yolande Pijnenburg, Annemiek Dols
OBJECTIVE: Primary psychiatric disorders (PsD) can present with symptomatology identical to that of behavioral variant frontotemporal dementia (bvFTD). To date, clinical guidelines do not provide a solution for this diagnostic challenge. The aim of our study was to prospectively determine which demographic, clinical, neuropsychological, neuroimaging, and cerebrospinal fluid biomarkers are important in distinguishing PsD from bvFTD. METHODS: Patients with late-onset behavioral disturbances (aged 45-75 years, 73% male) were included based on their scores on the Frontal Behavioral Inventory and the Stereotypy Rating Inventory and followed for 2 years from April 2011 to June 2015...
October 31, 2017: Journal of Clinical Psychiatry
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