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Journal of Child and Adolescent Psychopharmacology

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https://www.readbyqxmd.com/read/28170306/evaluating-diagnostic-and-statistical-manual-of-mental-disorders-fifth-edition-posttraumatic-stress-disorder-diagnostic-criteria-in-older-children-and-adolescents
#1
Amy J Mikolajewski, Michael S Scheeringa, Carl F Weems
OBJECTIVES: Few studies have assessed how the diagnostic criteria for posttraumatic stress disorder (PTSD) apply to older children and adolescents. With the introduction of a new, developmentally sensitive set of criteria for very young children (age 6 years and younger) in Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), this raises new questions about the validity of the criteria for older children and adolescents. The current study investigated how diagnostic changes in DSM-5 impact diagnosis rates in 7-18-year olds...
February 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28165318/an-evaluation-approach-for-the-performance-of-dosing-regimens-in-attention-deficit-hyperactivity-disorder-treatment
#2
Guillaume Bonnefois, Philippe Robaey, Olivier Barrière, Jun Li, Fahima Nekka
OBJECTIVE: Stimulant medications, with methylphenidate as the main agent, are the most prescribed for the treatment of attention-deficit/hyperactivity disorder. Nevertheless, real challenges still remain for clinicians concerned with adaptation of the therapeutic regimens, in terms of doses and timing, to children's daily activities. The aim of this study was to optimize short-acting methylphenidate regimens according to specific children's needs by evaluating the performance of a particular regimen through a web-based application...
February 6, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28157380/omega-3-fatty-acid-plasma-levels-before-and-after-supplementation-correlations-with-mood-and-clinical-outcomes-in-the-omega-3-and-therapy-studies
#3
L Eugene Arnold, Andrea S Young, Martha A Belury, Rachel M Cole, Barbara Gracious, Adina M Seidenfeld, Hannah Wolfson, Mary A Fristad
OBJECTIVE: To examine fatty acid profiles, their response to omega-3 fatty acid (Ω3) supplementation, and associations with clinical status and treatment response in youth with mood disorders. METHODS: In a placebo-controlled 2X2 design, 7-14 year-olds (N = 95) in parallel pilot trials (depression N = 72; bipolar N = 23) were randomly assigned to 12 weeks of Ω3 supplementation (1.4 g eicosapentaenoic acid [EPA], 0.2 g docosahexaenoic acid [DHA], and 0...
February 3, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28151703/the-child-behavior-checklist-obsessive-compulsive-subscale-detects-severe-psychopathology-and-behavioral-problems-among-school-aged-children
#4
Laura O Saad, Maria C do Rosario, Raony C Cesar, Marcelo C Bastituzzo, Marcelo Q Hoexter, Gisele G Manfro, Roseli G Shavitt, James F Leckman, Eurípedes C Miguel, Pedro G Alvarenga
OBJECTIVE: The aims of this study were (1) to assess obsessive-compulsive symptoms (OCS) dimensionally in a school-aged community sample and to correlate them with clinical and demographical variables; (2) to determine a subgroup with significant OCS ("at-risk for OCD") using the Child Behavior Checklist (CBCL-OCS) and (3) to compare it with the rest of the sample; (4) To review the CBCL-OCS subscale properties as a screening tool for pediatric OCD. METHODS: Data from the Brazilian High Risk Cohort were analyzed...
February 2, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28146638/predictors-of-nicotine-dependence-in-adolescents-symptoms-of-bipolar-disorder-and-attention-deficit-hyperactivity-disorder
#5
Ta-Chuan Yeh, Sheng-Chiang Wang, Yu-Tien Chang, Chin-Bin Yeh
OBJECTIVE: Bipolar disorder (BD) and attention-deficit/hyperactivity disorder (ADHD) have been associated with the use of cigarettes, but little is known about the impact of the subthreshold symptoms of BD or ADHD on the course of nicotine dependence. Identifying the links is essential for elucidating the pathway and supporting the development of nicotine prevention strategies for adolescents. METHODS: Participants (n = 3322) aged 15-17 years completed the Chinese version of the ADHD Self-Report Scale and the Mood Disorder Questionnaire...
February 1, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28140619/a-survey-of-pediatric-acute-onset-neuropsychiatric-syndrome-characteristics-and-course
#6
Denise Calaprice, Janice Tona, Ellisa Carla Parker-Athill, Tanya K Murphy
OBJECTIVE: To date, studies in the area of pediatric acute-onset neuropsychiatric syndrome (PANS; including pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection [PANDAS] and pediatric infection-triggered neuropsychiatric disorder [PITAND]) have been relatively small and hence unable to comprehensively address questions of disease heterogeneity (e.g., by age, gender), comorbidities, and progression. In this study, we investigated an internet survey sample to more fully characterize the phenotypic traits; medical, family, and developmental history; functional challenges; and clinical course associated with PANS...
January 31, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28121463/prevalence-of-acute-onset-subtypes-in-pediatric-obsessive-compulsive-disorder
#7
Fern Jaspers-Fayer, Sang Hun Jerry Han, Elaine Chan, Katherine McKenney, Annie Simpson, Andrea Boyle, Rhonda Ellwyn, S Evelyn Stewart
BACKGROUND: Pediatric obsessive-compulsive disorder (OCD) is a common, debilitating illness. When childhood OCD symptom onset is described as acute and severe, diagnostic criteria for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS) should be considered. However, the frequency and differentiating features of these putative syndromes within pediatric OCD remain poorly understood...
January 25, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28099039/gilles-de-la-tourette-syndrome-depression-depressive-illness-and-correlates-in-a-child-and-adolescent-population
#8
Renata Rizzo, Mariangela Gulisano, Davide Martino, Mary May Robertson
OBJECTIVE: Gilles de la Tourette syndrome (GTS) and depression are both common disorders. It has been suggested that depression occurs in 13%-76% GTS patients. Despite this, there are few studies into the specific relationships and correlates between the two disorders. There is only some consensus as to the precise relationship between the two disorders. MATERIALS AND METHODS: We undertook the study to investigate the relationship between depressive symptomatology and the core clinical features of GTS in a well-characterized clinical population of youth with this disorder...
January 18, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28051337/change-in-parental-depressive-symptoms-in-trauma-focused-cognitive-behavioral-therapy-results-from-a-randomized-controlled-trial
#9
Dunja Tutus, Ferdinand Keller, Cedric Sachser, Elisa Pfeiffer, Lutz Goldbeck
OBJECTIVES: Depressive symptoms are frequently described in parents whose children have been exposed to traumatic events. Hence, including nonoffending parents in trauma-focused cognitive-behavioral therapy (TF-CBT) for children and adolescents may help both children and their parents to cope with the trauma. Up to now, three randomized controlled trials have investigated parental depressive symptoms after TF-CBT. Given the ambiguous results, further effectiveness trials are needed to investigate parental benefit from TF-CBT...
January 4, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28009538/excessive-masturbation-association-with-mixed-amphetamine-salts
#10
Anita A Joseph, Anuradha Reddy
No abstract text is available yet for this article.
December 23, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28005403/preliminary-randomized-controlled-trial-of-habit-reversal-training-for-treatment-of-hair-pulling-in-youth
#11
Omar Rahman, Joseph McGuire, Eric A Storch, Adam B Lewin
OBJECTIVES: This study evaluated the treatment efficacy of habit reversal training (HRT) relative to treatment as usual (TAU) for children and adolescents aged 7-17 years with a primary diagnosis of trichotillomania (TTM). METHOD: An initial assessment consisting of semistructured interviews and rating scales was conducted. Participants (N = 40, 85% female) meeting diagnostic criteria for TTM were randomized to either 8 weekly sessions of HRT by trained therapists or 8 weeks of TAU...
December 22, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27991835/parent-reported-improvements-in-family-functioning-in-a-randomized-controlled-trial-of-lisdexamfetamine-for-treatment-of-parental-attention-deficit-hyperactivity-disorder
#12
Dara E Babinski, James G Waxmonsky, Daniel A Waschbusch, Hugh Humphery, William E Pelham
OBJECTIVE: This study examines the effects of parental stimulant medication treatment on parent ratings of parent-child functioning. Ratings of parent-child functioning in the home setting and immediately following a laboratory-based parent-child interaction were collected. METHOD: Participants were 20 parents who along with their children (ages 5-12 years) were diagnosed with Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) attention-deficit/hyperactivity disorder (ADHD)...
December 19, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27991834/caregiver-treatment-preferences-for-children-with-a-new-versus-existing-attention-deficit-hyperactivity-disorder-diagnosis
#13
Susan dosReis, Alex Park, Xinyi Ng, Emily Frosch, Gloria Reeves, Charles Cunningham, Ellen M Janssen, John F P Bridges
OBJECTIVES: Parental experiences with managing their child's attention-deficit/hyperactivity disorder (ADHD) can influence priorities for treatment. This study aimed to identify the ADHD management options caregivers most prefer and to determine if preferences differ by time since initial ADHD diagnosis. METHODS: Primary caregivers (n = 184) of a child aged 4-14 years old in care for ADHD were recruited from January 2013 through March 2015 from community-based pediatric and mental health clinics and family support organizations across the state of Maryland...
December 19, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27976935/oculomotor-abnormalities-in-children-with-attention-deficit-hyperactivity-disorder-are-improved-by-methylphenidate
#14
Maria Pia Bucci, Coline Stordeur, Mathilde Septier, Eric Acquaviva, Hugo Peyre, Richard Delorme
BACKGROUND: There are relatively few studies of saccadic eye movements in children with attention-deficit/hyperactivity disorder (ADHD). The aim of this study was to examine inhibitory abilities of eye movements in children with ADHD and to explore the effect of methylphenidate (MPH) on eye movement performance. METHODS: Thirty-one children with ADHD (mean age 9.9 ± 0.4 years) and 31 sex-, age-, and IQ-matched children with normal development were examined...
December 15, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27936898/pharmacokinetics-of-a-novel-amphetamine-extended-release-orally-disintegrating-tablet-in-children-with-attention-deficit-hyperactivity-disorder
#15
Jeffrey G Stark, Dorothy Engelking, Russ McMahen, Carolyn Sikes
BACKGROUND: A novel formulation for treating attention-deficit/hyperactivity disorder (ADHD) has recently been developed-amphetamine extended-release orally disintegrating tablets (AMP XR-ODTs). In this study, we assessed the rate of absorption and exposure of AMP XR-ODT under fasted conditions in children with ADHD. METHODS: Children (6-12 years) with ADHD were enrolled in a single-dose, open-label, single-period pharmacokinetic (PK) study. Patients were stratified by age (6-7, 8-9, and 10-12 year olds) and were dosed with 18...
December 12, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27935747/treatment-decision-making-capacity-in-children-and-adolescents-hospitalized-for-an-acute-mental-disorder-the-role-of-cognitive-functioning-and-psychiatric-symptoms
#16
Gabriele Mandarelli, Ugo Sabatello, Elisa Lapponi, Giulia Pace, Mauro Ferrara, Stefano Ferracuti
OBJECTIVE: This study was conducted to assess treatment decision-making capacity (TDMC) in a child and adolescent psychiatric sample and to verify possible associations between TDMC, psychiatric symptom severity, and cognitive functioning. METHODS: Twenty-two consecutively recruited patients hospitalized for an acute mental disorder, aged 11-18 years, underwent measurement of TDMC by the MacArthur Competence Assessment Tool for Treatment (MacCAT-T). The MacCAT-T interview focused on patients' current treatment, which comprised second-generation antipsychotics (45...
December 9, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27935735/pharmacokinetic-and-pharmacodynamic-properties-of-lisdexamfetamine-in-adults-with-attention-deficit-hyperactivity-disorder
#17
Lenard A Adler, Samuel Alperin, Terry Leon, Stephen V Faraone
BACKGROUND: Lisdexamfetamine (LDX) is a prodrug and consists of an active moiety, d-amphetamine, bound to lysine. Clinically, d-amphetamine becomes available postcleavage of the prodrug in the blood stream. Clinical effects of LDX in attention-deficit/hyperactivity disorder (ADHD) have been shown to persist up to 14 hours; however, pharmacokinetic (PK) data of LDX and amphetamine in ADHD adults are not currently available. OBJECTIVES: (1) To examine PK data of LDX and d-amphetamine in plasma and (2) to compare such PK data with Time-Sensitive ADHD Symptom Scale (TASS) ratings (PK vs...
December 9, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28212068/from-the-editor-in-chief-s-desk
#18
Harold S Koplewicz
No abstract text is available yet for this article.
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28212067/the-treatment-of-severe-childhood-aggression-study-12-weeks-of-extended-blinded-treatment-in-clinical-responders
#19
Robert L Findling, Lisa Townsend, Nicole V Brown, L Eugene Arnold, Kenneth D Gadow, David J Kolko, Nora K McNamara, Devin S Gary, Dana B Kaplin, Cristan A Farmer, Heidi Kipp, Craig Williams, Eric M Butter, Oscar G Bukstein, Robert Rice, Kristin Buchan-Page, Brooke S G Molina, Michael G Aman
OBJECTIVES: Previous "Treatment of Severe Childhood Aggression" (TOSCA) reports demonstrated that many children with severe physical aggression and attention-deficit/hyperactivity disorder (ADHD) responded well to two randomized treatments (parent training [PT]+stimulant+placebo = Basic vs. PT+stimulant+risperidone = Augmented) for 9 weeks. An important clinical question is whether these favorable outcomes are maintained over longer times. METHODS: Clinical responders to the 9-week trial (n = 103/168), defined as Clinical Global Impressions (CGI)-Improvement of much/very much improved plus substantial reduction in parent ratings of disruptiveness, were followed another 12 weeks (21 weeks total) while remaining on blinded treatment...
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28165762/extended-release-guanfacine-in-pediatric-anxiety-disorders-a-pilot-randomized-placebo-controlled-trial
#20
Jeffrey R Strawn, Scott N Compton, Brigitte Robertson, Anne Marie Albano, Mohamed Hamdani, Moira A Rynn
OBJECTIVE: This is a feasibility study evaluating the safety, tolerability, and potential anxiolytic efficacy of the α2 agonist guanfacine extended-release (GXR) in children and adolescents with generalized anxiety disorder (GAD), separation anxiety disorder (SAD), or social phobia/social anxiety disorder. METHODS: Youth aged 6-17 years with a primary diagnosis of GAD, SAD, and/or social anxiety disorder were treated with flexibly dosed GXR (1-6 mg daily, n = 62) or placebo (n = 21) for 12 weeks...
February 2017: Journal of Child and Adolescent Psychopharmacology
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