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Journal of Child and Adolescent Psychopharmacology

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https://www.readbyqxmd.com/read/30148662/-when-i-stop-my-medication-everything-goes-wrong-content-analysis-of-interviews-with-adolescent-patients-treated-with-psychotropic-medication
#1
Larissa Niemeyer, Lucca Schumm, Konstantin Mechler, Christine Jennen-Steinmetz, Ralf W Dittmann, Alexander Häge
OBJECTIVES: Medication nonadherence constitutes a major problem in adolescent psychiatry. Previous studies have identified various factors associated with nonadherent behavior. The aim of this study is to explore adolescents' health beliefs and subjective perceptions relating to psychotropic medication, and to statistically link these to reported medication adherence. METHODS: The findings presented in this study are part of the multicenter SEMA study (Subjective Experience and Medication Adherence in Adolescents with Psychiatric Disorders)...
August 27, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30148660/attention-deficit-hyperactivity-disorder-related-deficits-and-psychostimulant-medication-effects-on-comprehension-of-audiovisually-presented-educational-material-in-children
#2
Sarah A Orban, Tanya A Karamchandani, Leanne Tamm, Craig A Sidol, James Peugh, Tanya E Froehlich, William B Brinkman, Nicole Estell, Akemi E Mii, Jeffery N Epstein
OBJECTIVE: We aimed to (1) examine differences in observed visual attention and motor activity, as well as comprehension of a science video between children with and without attention-deficit/hyperactivity disorder (ADHD) and (2) explore if psychostimulant medication improves ADHD behaviors and comprehension of a science video in children with ADHD. METHOD: Children aged 7-11 with (n = 91) and without (n = 45) ADHD watched a science video and then completed a comprehension test...
August 27, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30148656/aripiprazole-methylphenidate-combination-in-children-and-adolescents-with-disruptive-mood-dysregulation-disorder-and-attention-deficit-hyperactivity-disorder-an-open-label-study
#3
Pei-Yin Pan, An-Ting Fu, Chin-Bin Yeh
OBJECTIVES: Disruptive mood dysregulation disorder (DMDD) is characterized by nonepisodic irritability and has a high rate of comorbidity with attention-deficit/hyperactivity disorder (ADHD). This is the first study to explore the effects of aripiprazole combined with methylphenidate on clinical symptoms and cognitive functions in patients with DMDD and ADHD. METHODS: Patients with DMDD and ADHD (the DMDD-ADHD Group, n = 24; aged 7-17 years) completed a 6-week, open-label trial of aripiprazole and methylphenidate...
August 27, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30132686/long-term-efficacy-and-safety-of-pediatric-prolonged-release-melatonin-for-insomnia-in-children-with-autism-spectrum-disorder
#4
Athanasios Maras, Carmen M Schroder, Beth A Malow, Robert L Findling, John Breddy, Tali Nir, Shiri Shahmoon, Nava Zisapel, Paul Gringras
OBJECTIVE: A recent double-blind randomized placebo-controlled study demonstrated 3-month efficacy and safety of a novel pediatric-appropriate prolonged-release melatonin (PedPRM) for insomnia in children and adolescents with autism spectrum disorder (ASD) and neurogenetic disorders (NGD) with/without attention-deficit/hyperactivity disorder comorbidity. Long-term efficacy and safety of PedPRM treatment was studied. METHODS: A prospective, open-label efficacy and safety follow-up of nightly 2, 5, or 10 mg PedPRM in subjects who completed the 13-week double-blind trial (51 PedPRM; 44 placebo)...
August 22, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30124331/physician-training-and-qualification-to-educate-patients-on-attention-deficit-hyperactivity-disorder-stimulant-diversion-and-misuse
#5
Natalie Colaneri, Sarah A Keim, Andrew Adesman
OBJECTIVES: The increased number of adolescents diagnosed with attention-deficit/hyperactivity disorder (ADHD) in recent years has raised concerns regarding diversion and misuse of prescription stimulant medications. As prescribers of these medications, physicians must be prepared to educate patients on these issues. This is the first study to evaluate physician training and qualification to educate adolescent patients on stimulant diversion and misuse. METHODS: A questionnaire was developed and mailed to a national sample of child and adolescent psychiatrists (CAPs), child neurologists (CNs), and developmental-behavioral pediatricians (DBPs) in the United States...
August 20, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30089215/relationship-between-aggravation-of-seizures-and-methylphenidate-treatment-in-subjects-with-attention-deficit-hyperactivity-disorder-and-epilepsy
#6
Jangho Park, Hae-Won Choi, Mi-Sun Yum, Tae-Sung Ko, Seung-Hyun Shon, Hyo-Won Kim
OBJECTIVES: We aimed to investigate the effectiveness and safety of methylphenidate (MPH), and especially its influence on seizures, in subjects with attention-deficit/hyperactivity disorder (ADHD) and epilepsy through a retrospective chart review of subjects treated with MPH in a clinical setting. We also evaluated factors that could affect seizure aggravation during MPH treatment. METHODS: From April 2004 to July 2011, MPH was prescribed to 105 subjects with ADHD and epilepsy...
August 8, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30085849/how-to-dose-attention-deficit-hyperactivity-disorder-medications-without-a-grain-of-salt
#7
Dorothy Engelking, Ann C Childress, Russ McMahen, Carolyn R Sikes
No abstract text is available yet for this article.
August 7, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30063169/update-on-randomized-placebo-controlled-trials-in-the-past-decade-for-treatment-of-major-depressive-disorder-in-child-and-adolescent-patients-a-systematic-review
#8
Martha J Ignaszewski, Bruce Waslick
OBJECTIVES: Antidepressant treatment for major depressive disorder (MDD) has been a topic of continued interest with a number of placebo randomized-controlled trials (RCTs) being published in the past decade. We review the updated literature since the 2007 Bridge meta-analysis, and reassess safety data looking at signals of treatment-emergent suicidality with the Columbia Suicide Severity Rating Scale (CSSR-S). METHODS: PubMed literature review was performed searching for RCTs published since the 2007 article and supplemented with manual search...
July 31, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30059243/escitalopram-in-the-treatment-of-anxiety-in-chromosome-18p-deletion
#9
Hannah Morrissey, Taniya Pradhan
No abstract text is available yet for this article.
July 30, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30048153/antipsychotic-medication-prescribing-trends-in-a-pediatric-population-in-northern-poland-2008-2012
#10
Przemysław M Waszak, Paweł Zagożdżon, Magdalena Pierucka, Alicja Kubanek
OBJECTIVES: In recent years antipsychotics have been increasingly used in the population of children and adolescents. The objective of this article is to profile the use of antipsychotic medications in a pediatric population in Poland based on data from the Pomeranian region (Northern Poland). METHODS: The study was based on National Health Fund data about prescription drug reimbursement between 2008 and 2012. A patient database was created using ID to analyze specific patterns and information about individuals using antipsychotics...
July 26, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30040434/medication-adherence-among-children-and-adolescents-with-severe-mental-illness-a-systematic-review-and-meta-analysis
#11
Juliet Beni Edgcomb, Bonnie Zima
OBJECTIVE: To perform a systematic review and meta-analysis of studies investigating predictors of medication adherence in children and adolescents with severe mental illness (SMI). METHOD: A systematic literature search was conducted in PubMed/MEDLINE, Web of Science, and PsycINFO from 1980 through October 1st, 2017, for original peer-reviewed articles that investigated predictors of adherence to psychopharmacologic treatment among children (≤18-years-old) with a primary psychotic disorder, bipolar disorder, depression, recent suicide attempt, or psychiatric hospitalization...
July 24, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30036076/relationship-between-symptomatic-and-functional-improvement-and-remission-in-a-treatment-response-to-stimulant-trial
#12
Margaret Weiss, Ann Childress, Greg Mattingly, Earl Nordbrock, Robert J Kupper, Akwete L Adjei
OBJECTIVE: To evaluate the relationship between symptom and functional improvement and remission in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) enrolled in an 11-week open-label dose-optimization phase of an methylphenidate extended release (MPH-MLR) pivotal study. METHODS: Assessments included the Weiss Functional Impairment Rating Scale-Parent (WFIRS-P) and ADHD Rating Scale, Fourth Edition (ADHD-RS-IV). Definitions included the following: symptom improvement (≥30% decrease in ADHD-RS-IV total score); symptom remission (ADHD-RS-IV total score ≤18); functional improvement (decrease in WFIRS-P total score ≥0...
July 23, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29975559/further-support-for-the-involvement-of-genetic-variants-related-to-the-serotonergic-pathway-in-the-antidepressant-response-in-children-and-adolescents-after-a-12-month-follow-up-impact-of-the-htr2a-rs7997012-polymorphism
#13
Patricia Gassó, Ana Blázquez, Natalia Rodríguez, Daniel Boloc, Teresa Torres, Sergi Mas, Amalia Lafuente, Luisa Lázaro
OBJECTIVE: Fluoxetine is an effective and well-tolerated pharmacological treatment for children and adolescents with major depressive disorder (MDD). However, a high percentage of patients do not respond. There is a substantial genetic contribution to this variable clinical outcome. Based on previous genetic results of our group and given the lack of pharmacogenetics studies of antidepressant response with a long follow-up period, we evaluated the influence of single nucleotide polymorphisms (SNPs) in genes related to the serotonergic pathway on remission and recovery in children and adolescents diagnosed with MDD after 12 months of initiating fluoxetine treatment...
July 5, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29969293/group-cognitive-behavioral-therapy-and-attention-bias-modification-for-childhood-anxiety-disorders-a-factorial-randomized-trial-of-efficacy
#14
Giovanni A Salum, Circe S Petersen, Rafaela B Jarros, Rudineia Toazza, Diogo DeSousa, Lidiane Nunes Borba, Stela Castro, Julia Gallegos, Paula Barrett, Rany Abend, Yair Bar-Haim, Daniel S Pine, Silvia H Koller, Gisele G Manfro
BACKGROUND: The objective of this study is to assess group differences in symptom reduction between individuals receiving group cognitive behavioral therapy (G-CBT) and attention bias modification (ABM) compared to their respective control interventions, control therapy (CT), and attention control training (ACT), in a 2 × 2 factorial design. METHODS: A total of 310 treatment-naive children (7-11 years of age) were assessed for eligibility and 79 children with generalized, separation or social anxiety disorder were randomized and received G-CBT (n = 42) or CT (n = 37)...
July 3, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30226806/from-the-editor-in-chief-s-desk
#15
Harold S Koplewicz
No abstract text is available yet for this article.
September 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30226805/fourteen-pound-fluvoxamine-associated-weight-gain-in-a-young-woman-with-depression-and-multiple-anxiety-symptoms
#16
Robert J Jaffe, Natasha S Juneja, Natasha S Juneja, Robert J Jaffe, Barbara J Coffey
No abstract text is available yet for this article.
September 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30004254/intravenous-ketamine-for-adolescents-with-treatment-resistant-depression-an-open-label-study
#17
Kathryn R Cullen, Palistha Amatya, Mark G Roback, Christina Sophia Albott, Melinda Westlund Schreiner, Yanan Ren, Lynn E Eberly, Patricia Carstedt, Ali Samikoglu, Meredith Gunlicks-Stoessel, Kristina Reigstad, Nathan Horek, Susannah Tye, Kelvin O Lim, Bonnie Klimes-Dougan
BACKGROUND: Novel interventions for treatment-resistant depression (TRD) in adolescents are urgently needed. Ketamine has been studied in adults with TRD, but little information is available for adolescents. This study investigated efficacy and tolerability of intravenous ketamine in adolescents with TRD, and explored clinical response predictors. METHODS: Adolescents, 12-18 years of age, with TRD (failure to respond to two previous antidepressant trials) were administered six ketamine (0...
September 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/30004236/lurasidone-in-children-and-adolescents-systematic-review-and-case-report
#18
Jonathan Channing, Mary Mitchell, Samuele Cortese
OBJECTIVE: To perform a systematic review of studies of lurasidone in children and/or adolescents and to present a case report aimed to add further insights into its use in clinical practice with youth. METHODS: We searched the following databases for empirical studies, of any design, focusing on the pharmacokinetics, efficacy, or safety of lurasidone in children and/or adolescents: Pubmed (Medline), OVID (PsycInfo, EMBASE+EMBASE classic, OVID Medline), Web of Knowledge, and ClinicalTrials...
September 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29975563/one-year-prospective-study-of-liver-function-tests-in-children-and-adolescents-on-second-generation-antipsychotics-is-there-a-link-with-metabolic-syndrome
#19
Inmaculada Baeza, Elena de la Serna, Rosa Calvo-Escalona, Jessica Merchán-Naranjo, Pamela Rodríguez-Latorre, M Carmen Martínez-Cantarero, Patricia Andrés, José Angel Alda, Daniel Muñoz-Samons, Daniel Ilzarbe, Celso Arango, Josefina Castro-Fornieles
OBJECTIVE: To analyze liver function tests (LFT), weight, metabolic syndrome (MetS) and at risk of meeting MetS criteria (AR-MetS) in children and adolescents on antipsychotics (AP) during a year-long follow-up. METHODS: Two hundred sixteen patients, AP naïve or quasi-naïve (<30 days on AP), were included. Total bilirubin, the enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), weight and other parameters of MetS were measured at baseline, and at 3, 6 and 12 months, while patients remained on the same AP...
September 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29975555/cardiovascular-events-following-treatment-initiation-with-atypical-antipsychotic-medications-in-publicly-insured-u-s-youth
#20
Mehmet Burcu, Julie M Zito, Daniel J Safer, Laurence S Magder, Susan dosReis, Fadia T Shaya, Geoffrey L Rosenthal
OBJECTIVE: To assess the risk of incident cardiovascular events that led to hospitalizations or emergency department visits following atypical antipsychotic (AAP) treatment initiation in youth according to dose, duration of use, and concomitant use of leading psychotropic medication classes. METHODS: We used computerized Medicaid claims to conduct a retrospective cohort study of youth (5-20 years) who initiated AAP treatment. AAP use was operationalized in a time-dependent manner according to current vs...
September 2018: Journal of Child and Adolescent Psychopharmacology
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