journal
https://read.qxmd.com/read/38407133/prevalence-of-aeroallergen-sensitization-in-children-in-northern-china
#21
JOURNAL ARTICLE
Sainan Bian, Wenjing Zhu, Kai Guan, Li Sha
OBJECTIVE: This study aimed to analyze the sensitization rate of different aeroallergens in children of different age, sex, and disease groups, describe the changing trend of different aeroallergens in different ages, and analyze the sensitization risk factors for asthma. METHODS: Children (<18 years old) with suspected atopic diseases who visited the Department of Allergy of Children's Hospital Affiliated to Capital Institute of Pediatrics and underwent a skin prick test (SPT) were retrospectively enrolled from January 2019 to November 2021...
February 26, 2024: Journal of Asthma
https://read.qxmd.com/read/38385570/impact-of-the-pulmonary-ventilation-function-on-the-prognosis-of-suspected-asthma-patients-a-retrospective-observational-study
#22
JOURNAL ARTICLE
Ming-Juan Zhou, Li Fu, Wen-Qian Lin, Zhen-Ni Wu, Fang Nie, Chu-Yin Ye, Wen-Han Zhao
OBJECTIVE: Asthma is a common chronic respiratory diseases, and the relationship between pulmonary ventilation function and the prognosis of patients with suspected asthma is not well understood. This study aims to explore the impact of pulmonary ventilation functions on the prognosis of patients with suspected asthma. METHODS: This retrospective observational study included patients with suspected asthma who were diagnosed and treated at the Guangdong Provincial Hospital of Traditional Chinese Medicine between August 2015 and January 2020...
February 22, 2024: Journal of Asthma
https://read.qxmd.com/read/38376812/n-acetyl-cysteine-augments-adipose-tissue-derived-stem-cell-efficacy-on-inflammatory-markers-and-regulatory-t-cell-system-balance-in-an-allergic-asthma-model
#23
JOURNAL ARTICLE
Maryam Radan, Farhad Abol Nejadian, Vahid Bayati, Ali Asghar Hemmati, Khojasteh Hoseinynejad, Seyyed Ali Mard
Background Allergic asthma is a destructive inflammatory process in the respiratory system. The anti-inflammatory and antioxidant effects of N-acetylcysteine (NAC) have been reported in patients with obstructive pulmonary disease. On the other hand, several studies have shown the modulatory effects of mesenchymal stem cells on the immune system and inflammatory responses. Accordingly, the purpose of the current study was to evaluate the effect of administration of adipose tissue-derived stem cells (ADSCs) plus NAC on regulatory T cell system balance in an allergic asthma model...
February 20, 2024: Journal of Asthma
https://read.qxmd.com/read/38376485/relationship-between-serum-iga-levels-and-low-percentage-forced-expiratory-volume-in-the-first-second-in-asthma
#24
JOURNAL ARTICLE
Sahoko Imoto, Maho Suzukawa, Kazufumi Takada, Shizuka Watanabe, Asari Isao, Takahide Nagase, Hiroyuki Nagase, Ken Ohta
Immunoglobulin A (IgA) is suggested to have pathogenic effects in respiratory inflammatory diseases, including asthma. We aimed to analyze the relationship between serum IgA, and clinical indicators and biomarkers of asthma.The present study was a post hoc analysis of the NHOM Asthma Study. In the present study, serum IgA was measured using serum samples stored. We determined an association between the serum IgA level and clinical variables and biomarkers using multivariate linear regression and analyzed the differences in clinical indices between IgA high- and IgA low-asthma...
February 20, 2024: Journal of Asthma
https://read.qxmd.com/read/38376119/clinical-characteristics-of-children-with-asthma-exacerbations-a-cross-sectional-descriptive-study
#25
JOURNAL ARTICLE
Ezgi Cay, Veysel Karakulak, Ahmet Sezer, Huseyin Baspinar, Nilgun Bahar, Busra Hatice Fidan, Mahir Serbes, Sevcan Bilen, Sevinc Puren Yucel, Dilek Ozcan, Derya Ufuk Altintas
Aim: In this cross-sectional descriptive study, we aimed to determine the clinical characteristics of children admitted to a tertiary hospital with asthma exacerbations in a city in southern Turkey where aeroallergens are common and to determine how these characteristics affect the severity of exacerbations. Methods: Data from a cross-sectional analysis of children with asthma exacerbations who were followed up at the Cukurova University Medical Faculty Pediatric Emergency Department (ED) and Pediatric Allergy & Immunology inpatient clinic were retrospectively analyzed...
February 20, 2024: Journal of Asthma
https://read.qxmd.com/read/38346176/activation-of-notch1-gata3-pathway-in-asthma-bronchial-epithelial-cells-induced-by-acute-pm2-5-exposure-and-the-potential-protective-role-of-microrna-139-5p
#26
JOURNAL ARTICLE
Junjun Huang, Yan Hu, Yunxia Wang, Zhou Jin
OBJECTIVE: PM2.5 is closed linked to asthma exacerbation. The Notch1 pathway acts as an important pathway, ultimately inducing T-helper cells that express GATA3 and its corresponding Th2 cytokines. The regulatory effects of miR-139-5p on the Notch1 pathway have been indicated in cancer. However, studies on miR-139-5p have not applied asthma-related models. The role of miR-139-5p and its regulatory effects on the Notch1-GATA3 pathway in asthma exacerbation induced by acute PM2.5 exposure has not been elucidated...
February 20, 2024: Journal of Asthma
https://read.qxmd.com/read/38359086/evaluation-of-the-quality-and-content-of-youtube-videos-as-an-educational-resource-in-developing-patients-inhaler-use-skills
#27
JOURNAL ARTICLE
Ozlem Canbolat, Ayse Buket DoganAktas, Gulhayat Sipal, Kokturk Nurdan
Background: YouTube has educational videos on inhalers. However, their content and quality are not adequately known. Objectives: This study investigated the quality and content of educational YouTube videos on inhalers. Methods: This descriptive study analyzed 178 YouTube videos on inhalers between May and July 2022. Two researchers independently evaluated the videos. The Global Quality Score, Journal of American Medical Association Benchmark Criteria, and Inhaler Application Checklist were used to assess the quality and content of the videos...
February 15, 2024: Journal of Asthma
https://read.qxmd.com/read/38359083/the-turkish-adaptation-of-the-adherence-to-asthma-medication-questionnaire
#28
JOURNAL ARTICLE
Döndü Erdoğan İnan, Ülkü Polat
Background: This study was conducted to adapt the Adherence to Asthma Medication Questionnaire (AAMQ-13) into Turkish. Methods: The research was conducted in the pulmonology outpatient clinic of a state hospital in Niğde/Türkiye. The sample consisted of 229 volunteers with asthma for at least one year. First, language and content validity were assessed. After evaluating the language validity and content validity of the questionnaire, internal consistency, split-half reliability and construct validity were examined...
February 15, 2024: Journal of Asthma
https://read.qxmd.com/read/38349366/toll-like-receptor-4-mediated-autophagy-regulates-airway-smooth-muscle-cells-behavior
#29
JOURNAL ARTICLE
LiXia Hou, HuiQing Zuo, Bo Xiao, Dong Yao
Objectives: Airway remodeling, a prominent feature of asthma, involves aberrant proliferation, apoptosis, and migration of airway smooth muscle cells (ASMCs). Toll-like receptors (TLRs) are implicated in regulation of the autophagy pathway. In this study, we aimed to investigate the influence of Toll-like receptor 4 (TLR4) on autophagy and its underlying mechanism in ASMC proliferation, apoptosis, and migration. Methods: Histopathological changes in the lungs of asthmatic mice assessed by Hematoxylin-Eosin (HE) and Masson staining...
February 13, 2024: Journal of Asthma
https://read.qxmd.com/read/38324665/emergency-management-and-asthma-risk-in-young-medicaid-enrolled-children-with-recurrent-wheeze
#30
JOURNAL ARTICLE
Isabel J Hardee, Isabella Zaniletti, Melisa S Tanverdi, Andrew H Liu, Rakesh D Mistry, Nidhya Navanandan
OBJECTIVES: To describe clinical characteristics of young children presenting to the emergency department (ED) for early recurrent wheeze, and determine factors associated with subsequent persistent wheeze and risk for early childhood asthma. METHODS: Retrospective cohort study of Medicaid-enrolled children 0-3 years old with an index ED visit for wheeze (e.g. bronchiolitis, reactive airway disease) from 2009 to 2013, and at least one prior documented episode of wheeze at an ED or primary care visit...
February 12, 2024: Journal of Asthma
https://read.qxmd.com/read/38323583/digitally-monitored-inhaled-therapy-a-smart-way-to-manage-severe-asthma
#31
JOURNAL ARTICLE
Dominic L Sykes, Yee Yong See, Evon C Y Chow, Michael G Crooks, Helena Cummings, Mandy Robinson, Karen Watkins, Joanne Thompson, Kylie Overton, Charlotte Riches, Shoaib Faruqi
One of the fundamental challenges of managing patients with severe asthma is treatment adherence, particularly with inhaled corticosteroids. Adherence is difficult to measure objectively and poor adherence is associated with worse outcomes. In this study, assess the ability of a 'smart' inhaler to record adherence in severe asthma patients and measure the impact of this on asthma control.Consecutive consenting patients meeting criteria for biologics had their existing high-dose ICS/LABA//LAMA combination inhaler/s switched to mometasone/indacaterol/glycopyrronium (114/46/136)...
February 7, 2024: Journal of Asthma
https://read.qxmd.com/read/38315158/effect-of-stearoyl-coenzyme-a-desaturase-1-scd1-on-the-function-of-mast-cells
#32
JOURNAL ARTICLE
Xiuqing Zhang, Aiguo Li, Yifan Zhu, Feng Liu, Deyu Zhao, Heng Tang, Changdi Xu
Background: The prevalence of childhood asthma and obesity is increasing, while obesity increases the risk and severity of asthma. Lipid metabolism has been considered as an important factor in the pathogenesis of obesity-associated asthma. Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that catalyzes the production of monounsaturated fatty acids (MUFA). Methods: In the present study, the microarray data retrieved from the Gene Expression Comprehensive Database (GEO) was analyzed to further clarify the impact of SCD1 on Mast cell activation related lipid mediators and the correlation between SCD1 and obesity asthma in the population...
February 5, 2024: Journal of Asthma
https://read.qxmd.com/read/38299937/evaluating-the-implementation-of-a-community-health-worker-delivered-intervention-integrating-asthma-care-in-west-philadelphia-public-schools
#33
JOURNAL ARTICLE
Kayla Clark, Elizabeth Messineo, Tyra Bryant-Stephens, Angela Song, Darby Marx, Adina Lieberman, Rinad S Beidas, Courtney Benjamin Wolk
OBJECTIVE: Schools are an important setting because students spend much of their time in school and engage in physical activity during the school day that could exacerbate asthma symptoms. Our objective is to understand the barriers and facilitators to implementing an experimental community health worker-delivered care coordination program for students with asthma within the context of the West Philadelphia Controls Asthma study. METHODS: Surveys (n = 256) and semi-structured interviews (n = 41) were completed with principals, teachers, nurses, and community health workers from 21 public and charter schools in West Philadelphia between January 2019 and September 2021...
February 1, 2024: Journal of Asthma
https://read.qxmd.com/read/38294863/rapidly-progressive-mucus-plugs-in-allergic-bronchopulmonary-mycosis
#34
JOURNAL ARTICLE
Osamu Miyazaki, Akira Igarashi, Kento Sato, Sumito Inoue, Ryuto Yokoyama, Masaki Nakane, Sahoko Kodama, Ryo Hasegawa, Shigeharu Ueki, Takashi Yaguchi, Akira Watanabe, Masafumi Watanabe
INTRODUCTION: Allergic bronchopulmonary mycosis (ABPM) is a chronic airway disease characterized by the presence of fungi that trigger allergic reactions and airway obstruction. Here, we present a unique case of ABPM in which a patient experienced sudden respiratory failure due to mucus plug-induced airway obstruction. The patient's life was saved by venovenous extracorporeal membrane oxygenation (VV-ECMO) and bronchoscopic removal of the plug. This case emphasizes the clinical significance of mucus plug-induced airway obstruction in the differential diagnosis of respiratory failure in patients with ABPM...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38294718/insight-into-the-role-of-mitochondrion-related-gene-anchor-signature-in-mitochondrial-dysfunction-of-neutrophilic-asthma
#35
JOURNAL ARTICLE
Lu Lin, Zeng-Hua Liao, Chao-Qian Li
OBJECTIVE: At present, targeting molecular-pharmacological therapy is still difficult in neutrophilic asthma. The investigation aims to identify and validate mitochondrion-related gene signatures for diagnosis and specific targeting therapeutics in neutrophilic asthma. METHODS: Bronchial biopsy samples of neutrophilic asthma and healthy people were identified from GSE143304 dataset and then matched with human mitochondrial gene data to obtain mitochondria-related differential genes (MitoDEGs)...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38294705/biologics-for-asthma-and-risk-of-pneumonia
#36
JOURNAL ARTICLE
Maria Gabriella Matera, Josuel Ora, Luigino Calzetta, Paola Rogliani, Mario Cazzola
OBJECTIVE: Modification of the immune system with biologics raises theoretical concerns about the risk of infections but it is still unclear whether currently routinely used biologics in severe asthma may facilitate the development of pneumonia. Therefore, we aimed to determine whether omalizumab, mepolizumab, benralizumab, and dupilumab are associated with pneumonia in a real-world setting. METHODS: A retrospective disproportionality analysis was performed using adverse event (AE) reports submitted to FAERS from January 2020 to September 30, 2023...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38294702/efficacy-of-bronchial-thermoplasty-in-a-patient-panel-with-uncontrolled-severe-persistent-asthma
#37
JOURNAL ARTICLE
Antonios Zikos, Marvin Balaan, Emily Hobart, Sandeep Bansal, Rihab Saeed, Tariq Cheema, Deborah Gentile
BACKGROUND: Bronchial thermoplasty (BT) is an approved procedure to manage uncontrolled severe persistent asthma. Many insurance providers are reluctant to pay for BT without proven benefit among their specific patient panel. OBJECTIVE: Determine if BT is effective in a panel patient panel with uncontrolled severe persistent asthma. STUDY DESIGN AND METHODS: This was an unblinded prospective study of adult subjects with uncontrolled severe persistent asthma who underwent BT...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38294683/atomized-inhalation-of-icaritin-reduces-airway-inflammation-and-remodeling-in-asthmatic-mice
#38
JOURNAL ARTICLE
Yintong He, Jian Cui, Bo Xiao, Lixia Hou, Zhimei Li, Huiqin Zuo, Yutong He, Dong Yao
Background: Asthma is a disease characterized by airway hyperresponsiveness and airway inflammation. Icaritin (ICT) is a plant hormone with various pharmacological activities such as anti-inflammatory, immune regulation, and anti-tumor. This study mainly explored the effects of nebulized inhalation of ICT on airway inflammation and airway remodeling in asthmatic mice. Method: Different groups of ovalbumin (OVA)-induced asthma mice with acute and chronic airway inflammation received ICT. Asthmatic mice received budesonide (BDND) aerosol inhalation as a positive control, while normal control and asthma model mice received the same volume of saline...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38294679/near-fatal-asthma-in-a-case-of-allergic-bronchopulmonary-aspergillosis-abpa-treated-with-ecmo
#39
JOURNAL ARTICLE
Shili Zhong, Zhengbin Wu, Chunyan Chen, Hong Xiao, Zhen Wang
BACKGROUND: Fatal asthma is a rapidly progressing and highly fatal form of asthma. Mechanical ventilation, although necessary for respiratory support, can exacerbate the condition and lead to ventilator-associated lung injury. ECMO therapy is crucial in allowing the lungs to rest and recover, as it provides extracorporeal membrane oxygenation. CASE PRESENTATION: A 40-year-old man presented with dyspnea following a mountain climb, which rapidly worsened, leading to respiratory failure and loss of consciousness...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38289083/there-is-no-association-between-serum-endotoxin-levels-and-inflammation-in-asthma
#40
JOURNAL ARTICLE
Ozlem Candan, Tayfur Toptas, Semra Demir, Fusun Erdenen
Backround Endotoxin, in lipopolysaccharide structure (LPS), is the main component of the outer membrane of gram negative bacteria. LPS levels were associated with inflammatory disease. Asthma is a chronic inflammatory disease involving many different cell types and cellular elements. The association between LPS serum levels and the asthma is not well known. The aim of this study was to investigate the association between the LPS serum levels and the severity of asthma, demographic data and laboratory parameters...
January 30, 2024: Journal of Asthma
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