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Journal of Asthma: Official Journal of the Association for the Care of Asthma

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https://www.readbyqxmd.com/read/28135899/insulin-use-increases-risk-of-asthma-but-metformin-use-reduces-the-risk-in-patients-with-diabetes-in-a-taiwanese-population-cohort
#1
Chiung-Zuei Chen, Chih-Hui Hsu, Chung-Yi Li, Tzuen-Ren Hsiue
objective -Recent reports have suggested that insulin promotes airway smooth muscle contraction and enhances airway hyperresponsiveness, which are cardinal features of asthma. In contrast, metformin can reduce both airway inflammatory and remodeling properties. However, these results are all from in vitro and animal studies. This study investigated whether diabetes and various antidiabetic agents associate with the risk of asthma. methods -We used a retrospective population-based cohort study using Taiwan's National Health Insurance claim database from 2000 to 2010 and a Cox proportional hazards regression model to compare the incidence of asthma between patients with diabetes (n = 19,428) and a matched non-diabetic group (n = 38,856)...
January 31, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28118056/multi-faceted-quality-improvement-initiative-to-decrease-pediatric-asthma-readmissions
#2
Nadia L Krupp, Cindy Fiscus, Russell Webb, Emily C Webber, Teresa Stanley, Rebecca Pettit, Ashley Davis, Judy Hollingsworth, Deborah Bagley, Marjorie McCaskey, John C Stevens, Andrea Weist, A Ioana Cristea, Heather Warhurst, Benjamin Bauer, Michele Saysana, Gregory S Montgomery, Michelle S Howenstine, Stephanie D Davis
BACKGROUND: Asthma is the most common chronic disease of childhood, and a leading cause of hospitalization in children. A primary goal of asthma control is prevention of hospitalizations. A hospital admission is the single strongest predictor of future hospital admissions for asthma. The 30-day asthma readmission rate at our institution was significantly above that of other hospitals in the Children's Hospital Association. As a result, a multi-faceted quality improvement project was undertaken with the goal of reducing the 30-day inpatient asthma readmission rate by 50% within two years...
January 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28102732/exacerbating-effects-of-pm2-5-in-ova-sensitized-and-challenged-mice-and-the-expression-of-trpa1-and-trpv1-protein-in-lung
#3
Hong Liu, Xinsheng Fan, Naiqian Wang, Yuyan Zhang, Jinghua Yu
OBJECTIVE: To investigate the effects of PM2.5 on asthma-related phenotypes and on the expression of TRPA1, V1 protein in lung in a mouse model of asthma. METHODS: Female Balb/c mice were utilized to establish 28 and 42 day asthma models. Mice were sensitized with OVA and challenged with OVA, OVA plus normal saline (NS), or OVA plus PM2.5 at two doses, 1.6 mg·kg(-1) or 8.0 mg·kg(-1). PM2.5 was administrated by intratracheal instillationwithout anesthesia. 24 hours after the final OVA challenge changes in airway resistance (RI) and lung compliance (Cdyn) in response to acetylcholine chloride (ACH) were evaluated, and blood, bronchoalveolar lavage fluid (BALF) and lung tissue samples were taken...
January 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28102717/seasonal-and-geographic-variation-in-the-incidence-of-asthma-exacerbations-in-the-united-states
#4
M Gerhardsson de Verdier, Per Gustafson, Christopher McCrae, Staffan Edsbäcker, Neil Johnston
BACKGROUND: Exacerbations drive the burden of asthma and lead to significant morbidity and consumption of healthcare resources. Many prior studies of the epidemiology of asthma exacerbations have relied upon data from hospital care. OBJECTIVE: To determine US patterns of geographic and seasonal variation of asthma exacerbations being defined as asthma episodes requiring hospital care and/or a prescription for oral steroid. METHODS: The study was a retrospective observational cohort study using administrative claims data for insured individuals from the HealthCore Integrated Research Database, including around 43 million members in US...
January 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28095128/safety-and-benefits-of-inhaled-hypertonic-saline-following-airway-challenges-with-endotoxin-and-allergen-in-asthmatics
#5
Neil E Alexis, William D Bennett, David B Peden
OBJECTIVE: To determine whether induced sputum (IS) with hypertonic saline inhalation is safe to use in asthmatics within 24 hours of two commonly used airway challenges, namely endotoxin and dust mite allergen, and to assess whether IS can enhance mucociliary clearance (MCC) rates in asthmatics. METHODS: IS (three 7 minute inhalation periods of 3, 4, 5% hypertonic saline) was employed before (N = 29) and within 24 hours of inhaled challenges with endotoxin (N = 13) and dust mite allergen (N = 12) in a cohort of mild to moderate asthmatics...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28095117/parents-asthma-information-needs-and-preferences-for-school-based-asthma-support
#6
Noha Abdullah Al Aloola, Lisa Nissen, Huda Abdullaziz Alewairdhi, Nawaf Al Faryan, Bandana Saini
Objectives This study sought to investigate parents' needs and preferences for school-based asthma support in Saudi Arabian primary schools. Methods Semi-structured qualitative interviews were conducted in the period between November 2015 and February 2016, with a convenience sample that comprised Saudi parents and carers of children with asthma. Recruitment of participants was primarily driven through Saudi primary schools; passive snowballing and social networks were used to boost participation rates further...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28095080/missed-opportunities-to-transition-from-nebulizers-to-inhalers-during-hospitalization-for-acute-asthma-a-multi-center-observational-study
#7
Valerie G Press, Kohei Hasegawa, Jonathan Heidt, Jane C Bittner, Carlos A Camargo
OBJECTIVE: Hospitalizations for acute asthma are thought to be highly preventable through the use of efficacious medications, though many patients have poor metered-dose inhaler (MDI) technique, lessening these medications' real-world effectiveness. Teaching MDI technique during hospitalization may therefore lead to improved outcomes. However, MDIs may be underutilized to deliver short-acting β-agonists in the inpatient setting, despite equivalent efficacy to nebulizer delivery. We sought to characterize delivery methods of short-acting beta-agonist (SABA) therapy among hospitalized patients with acute asthma to understand if there are missed opportunities for self-management education...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28095072/parental-coping-depressive-symptoms-and-children-s-asthma-control-and-school-attendance-in-low-income-racially-and-ethnically-diverse-urban-families
#8
Erin M Rodríguez, Harsha Kumar, Juliana Alba-Suarez, Lisa Sánchez-Johnsen
OBJECTIVE: Low-income urban children of color are at elevated risk for poor asthma control. This cross-sectional study examined associations among parents' coping (primary control, secondary control, and disengagement), parental depressive symptoms, and children's asthma outcomes (asthma control and school attendance) in a predominantly low-income, racially/ethnically diverse sample of families. METHODS: Parents (N = 78; 90% female) of children (33% female; 46% Black; 38% Latino) ages 5 to 17 years old (M = 9...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28095068/impact-of-telepharmacy-services-as-a-way-to-increase-access-to-asthma-care
#9
Wendy Brown, David Scott, Daniel Friesner, Tara Schmitz
OBJECTIVE: To demonstrate that real-time, telepharmacy-based asthma educational services are feasible and support the efforts of local primary care prescribers to improve patient outcomes. METHODS: The lead investigator [a pharmacist, physician assistant and certified asthma educator] identified an independent community pharmacy with telehealth capabilities in a rural area with a high prevalence of asthma. Working with the pharmacy, an asthma education program was developed based on the National Asthma Education and Prevention Program guidelines...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28075198/impact-of-a-history-of-maternal-depression-and-anxiety-on-asthma-control-during-pregnancy
#10
Luke E Grzeskowiak, Brian Smith, Anil Roy, K Oliver Schubert, Bernhard T Baune, Gustaaf A Dekker, Vicki L Clifton
OBJECTIVE: To determine the impact of self-reported maternal depression/anxiety on asthma control during pregnancy. METHOD: Pregnant women with a doctor diagnosis of asthma (n = 189) were prospectively recruited at their antenatal booking visit and the presence of maternal depression and anxiety was identified using self-report and routine questionnaire assessments. Data on exacerbations and asthma control were collected during gestation. Asthma control was assessed using the Juniper asthma control questionnaire and women were classified as having recurrent uncontrolled asthma if their ACQ score was > 1...
January 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28060556/the-frequency-of-sleep-disordered-breathing-in-children-with-asthma-and-its-effects-on-asthma-control
#11
Tayfur Ginis, Fatih Alper Akcan, Murat Capanoglu, Muge Toyran, Refika Ersu, Can Naci Kocabas, Ersoy Civelek
BACKGROUND: The presence of sleep-disordered breathing (SDB) in children with asthma may cause difficult to control asthma. OBJECTIVES: The aim of this study was to determine the frequency of SDB in children with asthma, to evaluate its effects on asthma control and to assess the risk factors associated with the presence of SDB. METHODS: Parents of children who Sleep Questionnaire (PSQ) and the Childhood Asthma Control Test (C-ACT). Asthma control level was assessed according to Global Initiative for Asthma (GINA)...
January 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055281/effects-of-bronchoscopy-on-lung-function-in-asthmatics
#12
Christina Bellinger, Eugene R Bleecker, Stephen P Peters, Rodolfo M Pascual, Jeffrey Krings, Regina V Smith, Annette Hasties, Wendy C Moore
BACKGROUND: To better understand changes in pulmonary physiology related to asthma severity following bronchoscopy, we performed scheduled pre- and post-procedure spirometry on all subjects undergoing bronchoscopy in our research program. METHODS: Control subjects and asthma subjects of all severity were recruited for bronchoscopy. On the day of bronchoscopy, subjects underwent spirometry when they arrived, after pre-bronchoscopy treatment with albuterol and then up to three sets within two hours following completion of the bronchoscopy...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055280/spatiotemporal-patterns-of-childhood-asthma-hospitalization-and-utilization-in-memphis-metropolitan-area-from-2005-to-2015
#13
Tonny J Oyana, Pradeep Podila, Jagila Minso Wesley, Slawo M Lomnicki, Stephania A Cormier
OBJECTIVE: To identify key risk factors and explain spatiotemporal patterns of childhood asthma in the Memphis Metropolitan Area (MMA) over an 11-year period (2005 to 2015). We hypothesize that in the MMA region this burden is more prevalent among urban children living south, downtown, and north of Memphis than other areas. METHODS: We used a large-scale longitudinal electronic health record database from an integrated healthcare system, GIS, statistical, and space-time models to study spatiotemporal distributions of childhood asthma at census-tract level...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055276/quality-of-life-of-asthmatic-children-and-adolescents-portuguese-translation-adaptation-and-validation-of-the-questionnaire-pediatric-quality-of-life-pedsql-asthma-module
#14
Fernanda Pereira Monteiro, Dirceu Solé, Gustavo Falbo Wandalsen
OBJECTIVE: To translate, validate and verify the psychometric properties of the Portuguese version of the instrument "Pediatric Quality of Life Asthma Module" (PedsQL Asthma) culturally adapted for the Brazilian culture. METHODS: After being translated to Portuguese and culturally adapted, the questionnaire was answered by 200 asthmatic children and adolescents (ages 2 to 18) as well as the adults responsible for them. Validation required the use of the following instruments, PedsQL Asthma Children (applied to children and adolescents), PedsQL Asthma Parents (applied to adults responsible for children and adolescents), Pediatric Asthma Quality of Life (PAQLQ), Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT), as well as socio-economic and personal information questionnaires...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055274/does-the-medical-diagnosis-of-occupational-asthma-coincide-with-the-legal-diagnosis
#15
Zeynep Çelebi Sözener, Ömür Aydın, Yavuz Selim Demirel, Şadan Soyyiğit, Pamir Çerçi, Reşat Kendirlinan, Sevim Bavbek, Gülfem Elif Çelik, Zeynep Mısırlıgil, Betül Ayşe Sin, Arif Keleşoğlu, Dilşad Mungan
Objective The incidence of occupational asthma(OA) is increasing worldwide. In this study, we first aimed to document the rate of diagnosis of OAamong patients who were referred to our clinic from Social Security Institution and factors that affected diagnosis, and secondly, we aimed to assess the consistency of the medical diagnosis and the legal diagnosis. Methods The study involved 132 consecutive patients who were referred to our clinic for evaluation of OA between 2010 and 2015. Detailed workplace history,the tools used in the diagnosis such as peak expiratory flow(PEF) monitoring and bronchial provocation tests and final medical diagnosis were recorded from case files...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055272/rs12603332-is-associated-with-male-asthma-patients-specifically-in-urban-areas-of-lahore-pakistan
#16
Muhammad Farooq Sabar, Mariam Shahid, Iqbal Bano, Muhammad Usman Ghani, Muhammad Akram, Farheena Iqbal, Samra Kousar, Zafar Iqbal, Saba Altaf, Tayyab Husnain
OBJECTIVE: rs12603332, an important regulatory site variant, is known to alter the regulatory motif E2A that is involved in maturation of B-lymphocytes. The study was designed to check whether different environmental exposures alter its risk allele association with asthma or not. METHODS: 200 Physician diagnosed asthma patients and 108 healthy individuals were enrolled from hospitals of Lahore. After quantitation of DNA extracted from their peripheral blood samples, amplification of genomic region with rs12603332 was performed followed by single base extension...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055271/airway-hyperresponsiveness-to-mannitol-and-methacholine-and-exhaled-nitric-oxide-in-children-with-asthma
#17
Young A Park, Hyun Bin Park, Yoon Hee Kim, In Sook Sul, Seo Hee Yoon, Hye Ran Kim, Kyung Won Kim, Kyu-Earn Kim, Myung Hyun Sohn
No abstract text is available yet for this article.
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055270/takotsubo-cardiomyopathy-a-known-unknown-foe-of-asthma
#18
Ourania S Kotsiou, Alexandros Douras, Demosthenes Makris, Nikoleta Mpaka, Konstantinos I Gourgoulianis
INTRODUCTION: Patients with uncontrolled asthma are at a greater risk of asthma attacks requiring emergency room visits or hospital admissions. Takotsubo cardiomyopathy is potentially a significant complication in a course of status asthmaticus. CASE STUDY: We present a 43-year-old female patient who presented with status asthmaticus further complicated with takotsubo cardiomyopathy. RESULTS: Recognizing apical ballooning syndrome is challenging in patients with a history of respiratory disease because the symptoms of the last entity may complicate the diagnostic approach...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28055268/perceptions-about-interpersonal-relationships-and-school-environment-among-middle-school-students-with-asthma
#19
Hyekyun Rhee, Brenda McQuillan, Ding-Geng Chen, Shannska Atis
OBJECTIVES: To examine interpersonal relationships involving peers and teachers and perceptions about school environment among middle school students with asthma in comparison to their healthy counterparts. The study also assesses asthma prevalence in a large sample of middle school students representing different geographic locations. METHODS: Cross-sectional data were collected from 1059 middle school students in grades 6-8 enrolled in schools in a northeastern region of the U...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28045551/use-of-a-low-literacy-written-action-plan-to-improve-parent-understanding-of-pediatric-asthma-management-a-randomized-controlled-study
#20
Hsiang Shonna Yin, Ruchi Gupta, Alan L Mendelsohn, Benard P Dreyer, Linda van Schaick, Christina R Brown, Karen Encalada, Dayana Sanchez, Christopher Warren, Suzy Tomopoulos
OBJECTIVES: To determine whether parents who use a low literacy, pictogram- and photograph-based written asthma action plan have a better understanding of child asthma management compared to parents using a standard plan. METHODS: Randomized controlled study in 2 urban pediatric outpatient clinics. INCLUSION CRITERIA: English/Spanish-speaking parents of 2-12 year old asthmatic children. Parents were randomized to receive a low literacy or standard asthma action plan (American Academy of Allergy, Asthma and Immunology) for a hypothetical patient on controller and rescue medications...
January 3, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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