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Journal of Asthma: Official Journal of the Association for the Care of Asthma

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https://www.readbyqxmd.com/read/29771599/clinical-characterization-of-children-with-resistant-airflow-obstruction-a-multicenter-study
#1
Sankaran Krishnan, Allen J Dozor, Leonard Bacharier, Jason E Lang, Charles G Irvin, David Kaminsky, Harold J Farber, Lynn Gerald, Mark Brown, Janet T Holbrook, Robert A Wise, Julie Ryu, Sonali Bose, Yasin Razan, Joy Saams, Robert J Henderson, William G Teague
OBJECTIVE: To characterize a cohort of children with airflow limitation resistant to bronchodilator (BD) therapy. METHODS: Pulmonary function tests performed in children 6-17 years of age at 15 centers in a clinical research consortium were screened for resistant airflow limitation, defined as a post-BD FEV1 and/or an FEV1 /FVC less than the lower limits of normal. Demographic and clinical data were analyzed for associations with pulmonary function. RESULTS: 582 children were identified...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29771597/concordance-between-survey-reported-childhood-asthma-and-linked-medicaid-administrative-records
#2
Benjamin Zablotsky, Lindsey I Black
OBJECTIVE: Agreement between administrative and survey data has been shown to vary by the condition of interest and there is limited research dedicated to parental report of asthma among children. The current study assesses the concordance between parent-reported asthma from the National Health Interview Survey (NHIS) with Medicaid administrative claims data among linkage eligible children from the NHIS. METHODS: Medicaid Analytic eXtract (MAX) files from the Centers for Medicare & Medicaid Services (CMS) (years 2000-2005) were linked to participants of the NHIS (years 2001-2005)...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29746201/development-of-a-graphical-tool-to-measure-medication-adherence-in-asthma-patients-a-mixed-methods-pilot-study
#3
Alia Yousif, Catherine Lemière, André Cartier, Amélie Forget, Lucie Blais, For The Resp Investigators
OBJECTIVES: 1) To develop Med-Resp, a graphical tool based on prescription refills to measure adherence and use of asthma medications; 2) To test the feasibility of implementing Med-Resp in a hospital outpatient asthma clinic; 3) To explore the effectiveness of Med-Resp to improve medication adherence to asthma controller medications. METHODS: A sequential exploratory design was used: 1) Prototype design in collaboration with respiratory physicians and patients via focus groups; 2) Med-Resp creation based on algorithms developed and applied to prescription refills data recorded in the drug claims database reMed; 3) Feasibility assessment of the implementation of Med-Resp in the outpatient asthma clinic; and 4) Exploration of the effectiveness of Med-Resp through a pre-post design...
May 10, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29746175/informed-consent-current-challenges-and-lessons-learned-from-the-american-lung-association-asthma-airways-clinical-research-centers-network-ala-acrc
#4
Jason E Lang, Anusha Vadlamudi
True informed consent is a vital component of clinical research. Obtaining informed consent involves informing the subject about the study purpose, any tests and procedures that may be involved, his or her rights, and potential risks and benefits of participation. Over the past few decades, informed consent documents have gotten longer and more complicated in order to comply with regulatory standards. This jeopardizes participant understanding and the intended purpose of the document. We analyzed the complexity of informed consent documents in 8 American Lung Association Asthma Clinical Research Center (ALA-ACRC) clinical trials taking place between 2000 and 2015...
May 10, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29738276/psychosocial-risk-factors-and-asthma-among-adults-in-puerto-rico
#5
Yueh-Ying Han, Erick Forno, Glorisa Canino, Juan C Celedón
OBJECTIVE: Asthma and psychosocial stressors are common among Puerto Rican adults living in the United States. We estimated the prevalence of current asthma, and examined potential psychosocial risk factors and current asthma, among adults in Puerto Rico. METHODS: Cross-sectional study of 3,049 Puerto Ricans aged 18-64 years living in Puerto Rico between May 2014 and June 2016. A structured interview was conducted to obtain information on demographics, lifestyles, mental disorders, and respiratory health...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29738272/fall-episodes-in-elderly-patients-with-asthma-and-copd-a-pilot-study
#6
Andrzej Bozek, Jerzy Jarzab, Ewa Hadas, Marek Jakalski, Giorgio Walter Canonica
OBJECTIVE: Evidence of an increased risk of falls in patients with chronic obstructive pulmonary disease (COPD) exists; however, this has not been studied in elderly asthmatic patients. The aim of the study was to determine the incidence of falls in elderly patients who were diagnosed with bronchial asthma compared to subjects with COPD. METHODS: A 12 - month prospective observational study in elderly outpatients with diagnosis of either asthma or COPD was conducted...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29738270/association-between-pediatric-asthma-care-quality-and-morbidity-and-english-language-proficiency-in-ohio
#7
Martha P Montgomery, Elizabeth D Allen, Olivia Thomas, Byron F Robinson, Donnie Clark, Ann Connelly, Joshua A Mott, Elizabeth Conrey
OBJECTIVE: Limited English proficiency can be a barrier to asthma care and is associated with poor outcomes. This study examines whether pediatric patients in Ohio with limited English proficiency experience lower asthma care quality or higher morbidity. METHODS: We used electronic health records for asthma patients aged 2-17 years from a regional, urban, children's hospital in Ohio during 2011-2015. Community-level demographics were included from U.S. Census data...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29733738/case-study-a-combination-of-mepolizumab-and-omaluzimab-injections-for-severe-asthma
#8
Rejmon Dedaj, Lindie Unsel
A Combination of Mepolizumab and Omaluzimab injections for severe asthma. INTRODUCTION: Patients with severe persistent asthma account for a large proportion of asthma morbidity and health care expenditures. In this case report we describe the use of a combination of omalizumab and mepolizumab in severe asthma with elevated IgE levels and eosinophilic phenotype. CASE STUDY: We are treating a 55 year old woman with severe persistent eosinophilic asthma and elevated IgE levels...
May 7, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29722589/evidence-based-pediatric-asthma-interventions-and-outcome-measures-in-a-healthy-homes-program-an-integrative-review
#9
Jeannie K Giese
OBJECTIVE: Asthma disproportionately impacts and has poorer outcomes in low-income, minority, and inner-city children. The home environment has a profound impact on a child's asthma. Home-based asthma visits have the potential to positively impact a child's asthma, especially in targeted populations. The purpose of this integrative review is 1.) to explore the effectiveness of home-based education and environmental measures and 2.) to explore specific indicators and tools to measure pediatric asthma control and program effectiveness...
May 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29720013/general-practitioners-experiences-of-asthma-management-in-culturally-and-linguistically-diverse-populations
#10
Reem Alzaye, Betty Bouad Chaar, Iman A Basheti, Bandana Saini
OBJECTIVE:  The purpose of this study was to explore General Practitioners' experiences and perspectives about asthma management of culturally and linguistically diverse (CALD) people with asthma, particularly with reference to Arabic speaking patients with low English proficiency (LEP). METHODS:  Semi-structured interviews guided by an interview protocol were conducted with general practitioners who deal with CALD patients with asthma. Participants were recruited from medical practices in Melbourne, Australia...
May 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29718784/the-self-reported-prevalence-and-disease-burden-of-asthma-in-greece
#11
Georgia Kourlaba, Petros Bakakos, Stelios Loukides, Katerina Vellopoulou, Argyro Solakidi, Nikos Maniadakis
OBJECTIVES: The primary objective was to estimate the self-reported prevalence of asthma in Greece. The secondary one was to assess the impact of asthma control on patients' health related Quality-of-Life (HRQoL), productivity loss, daily activities and psychological distress. METHODS: A population-based, random-digit dialing, telephone nationwide survey was conducted to recruit patients with asthma. Among the responders, 3,946 met the age criterion (≥18 years) and completed the screening questions regarding asthma...
May 2, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29718738/treatment-of-severe-uncontrolled-eosinophilic-asthma-where-we-are-heading
#12
Jonathan A Bernstein, Reynold Panettieri
OBJECTIVE: We sought to highlight how our understanding of the pathophysiology of severe asthma has evolved over time and discuss the role of biomarkers in treatment advances and emerging new therapies. DATA SOURCES: Nonsystematic PubMed literature search. STUDY SELECTION: Articles were selected based on areas of relevance to the classification of asthma by endotype, with an emphasis on the evolution of current treatment guidelines for severe asthma...
May 2, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29716412/trends-in-asthma-self-management-skills-and-inhaled-corticosteroid-use-during-pregnancy-and-postpartum-from-2004-to-2017
#13
Annelies L Robijn, Megan E Jensen, Peter G Gibson, Heather Powell, Warwick B Giles, Vicki L Clifton, Joerg Mattes, Michael J Peek, Helen L Barrett, Sean K Seeho, Leonie K Callaway, Alistair Abbott, John Attia, Peter A Wark, Vanessa E Murphy
OBJECTIVE: Asthma exacerbations and medication non-adherence are significant clinical problems during pregnancy. While asthma self-management education is effective, the number of education sessions required to maximise asthma management knowledge and inhaler technique and whether improvements persist postpartum, is unknown. This paper describes how asthma knowledge, skills, and inhaled corticosteroid (ICS) use have changed over time. METHODS: Data were obtained from three cohorts of pregnant women with asthma recruited in Newcastle, Australia between 2004-2017 (N = 895)...
May 2, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29714602/asthma-control-and-adherence-in-newly-diagnosed-young-and-elderly-adult-patients-with-asthma-in-turkey
#14
Bilun Gemicioglu, Hasan Bayram, Arif Cimrin, Oznur Abadoglu, Aykut Cilli, Esra Uzaslan, Hakan Gunen, Levent Akyildiz, Mecit Suerdem, Tevfik Ozlu, Zeynep Misirligil
OBJECTIVE: This study aimed to evaluate the factors that affect asthma control and adherence to treatment in newly diagnosed elderly asthmatics in Turkey compared with younger patients. METHODS: This real-life prospective observational cohort study was conducted at 136 centers. A web-based questionnaire was administered to the patients who were followed up for 12 months. RESULTS: Analysis included 1037 young adult asthma patients (age <65 years) and 79 elderly asthma patients (age ≥65 years)...
May 1, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29714513/perceptions-of-non-traditional-tobacco-products-between-asthmatic-and-non-asthmatic-college-students
#15
Mary P Martinasek, Robin M White, Christopher W Wheldon, Linda Gibson-Young
OBJECTIVE: Electronic nicotine delivery systems (ENDS) use is common among college students and there are perceptions that ENDS are not as harmful as traditional cigarettes. The aim of this study was to examine differences in ENDS use, risk perceptions and co-occurring smoking behaviors between college students with and without asthma. METHODS: The study consisted of a cross-sectional online survey with a final sample size of 898 college students. The voluntary participation survey was disseminated to all undergraduate and graduate students at a mid-sized liberal arts university in the Southeast U...
May 1, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29712498/responsiveness-of-children-s-global-health-to-improvements-in-acute-asthma
#16
Christopher B Forrest, Joseph J Zorc, JeanHee Moon, Ramya Pratiwadi, Brandon D Becker, Mitchell G Maltenfort, James P Guevara
OBJECTIVE: To evaluate the reliability and validity of the PROMIS Pediatric Global Health scale, a 7-item measure of perceived physical, mental, and social health, in children with asthma. METHODS: From February 2014 to February 2015, convenience samples of children 8-17 years-old (n = 182) and parents of children 5-17 years-old (n = 328) visiting an emergency department for treatment of asthma were enrolled. The Asthma Control Test was used to characterize children as controlled versus not controlled, and the PROMIS Asthma Impact Scale was used to assess the effects of asthma symptoms on functional status...
May 1, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29693465/the-influence-of-prenatal-mental-health-service-use-on-the-incidence-of-childhood-asthma-a-population-based-cohort-study
#17
Dhenuka Radhakrishnan, Salimah Z Shariff, Teresa To
OBJECTIVES: We aimed to determine whether maternal mental health service use during pregnancy, a potential proxy measure of prenatal maternal stress, is associated with the development of asthma in a large population-based sample of children. We hypothesized that children born to mothers with mental health service use during pregnancy would have a higher incidence of childhood asthma. STUDY DESIGN: Health administrative data from Ontario, Canada (population >13 million) was used to identify pairs of mothers linked with their children born between April 1, 2001 to March 31, 2002...
April 25, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29693462/the-current-prevalence-of-asthma-allergic-rhinitis-and-eczema-related-symptoms-in-school-aged-children-in-costa-rica
#18
M E Soto-Martínez, A Yock-Corrales, K Camacho-Badilla, S Abdallah, N Duggan, L Avila-Benedictis, J J Romero, M E Soto-Quirós
OBJECTIVE: Asthma prevalence in Costa Rica is among the highest worldwide. We aimed to determine the prevalence of asthma among school-age children in the Central Highland Area of Costa Rica. METHODS: Cross-sectional study using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was performed. Parents or guardians of children aged 6-13 years completed written questionnaires. RESULTS: Total of 2817 school-aged children returned these questionnaires (74...
April 25, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29693459/evaluating-the-effectiveness-of-systemic-corticosteroids-to-mitigate-relapse-in-children-assessed-and-treated-for-acute-asthma-a-network-meta-analysis
#19
Scott W Kirkland, Ben Vandermeer, Sandy Campbell, Cristina Villa-Roel, Amanda Newton, Francine M Ducharme, Brian H Rowe
OBJECTIVE: The objective of this systematic review was to explore the effectiveness of various systemic corticosteroid (SCS) regimens to mitigate relapse in children with asthma discharged from an acute care setting. DATA SOURCES: Medline, EMBASE, Global Health, International Pharmaceutical Abstracts, EMB ALL, CINAHL, SCOPUS, Proquest Dissertations and Theses Global, and LILACS were searched using controlled vocabulary and key words. Additional citations were searched via clinical trial registries, Google Scholar, bibliographies, a SCOPUS forward search of a sentinel paper, and hand searching conference abstracts...
April 25, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29688092/predictors-of-future-exacerbations-in-a-multi-ethnic-asian-population-with-asthma
#20
Tunn Ren Tay, Hang Siang Wong, Augustine Tee
OBJECTIVE: Exacerbations are important outcomes in asthma. Risk factors for exacerbations may differ in different populations. Although various demographic and clinical variables were examined in previous studies on exacerbation risks in asthma, important variables such as ethnicity, adherence, and medication titration were not included. This study examined independent predictors of future exacerbations in a multi-ethnic asthma population in Asia, while including the variables of ethnicity, medication adherence, and medication change in our analysis...
April 24, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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