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Journal of Asthma: Official Journal of the Association for the Care of Asthma

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https://www.readbyqxmd.com/read/28933971/the-pharmacokinetics-safety-and-tolerability-of-single-high-strength-doses-of-fluticasone-propionate-and-fluticasone-propionate-salmeterol-delivered-via-a-novel-multidose-dry-powder-inhaler-in-adolescents-and-adults-with-persistent-asthma
#1
Courtney Nugent, Gloria Yiu, Sharon Song, Cynthia Caracta
OBJECTIVE: Characterize fluticasone propionate (Fp) and combination fluticasone propionate and salmeterol (FS) pharmacokinetic and safety profiles, delivered via a novel, inhalation-driven, multidose dry powder inhaler (MDPI). METHODS: This multicenter, open-label, 4-period crossover, single-dose study randomized patients aged ≥12 years with persistent asthma to Fp MDPI 200 mcg, FS MDPI 200/12.5 mcg, Fp dry powder inhaler (DPI) 500 mcg (250 mcg × 2 inhalations), or FS DPI 500/50 mcg...
September 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28933570/developing-pictorial-asthma-action-plans-to-promote-self-management-and-health-in-rural-youth-with-asthma-a-qualitative-study
#2
Christina L Duncan, Heather A Walker, Laurel Brabson, Desireé N Williford, Lisa Hynes, Mary Beth Hogan
OBJECTIVE: Asthma action plans (AAPs) provide asthma management instructions to families; however, AAPs typically are written at a 7(th)-9(th) grade reading level, making them less useful in lower literacy families. There is a need to develop simpler AAP formats and content to optimize their utility across all families, including those who are rural and may be at risk for literacy concerns. Because using pictures can simplify and enhance health education, our study aim was to develop a pictorial AAP through a series of focus groups with key stakeholders - youth with asthma, caregivers, and physicians...
September 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28925768/the-impact-of-long-term-systemic-glucocorticoid-use-in-severe-asthma-a-uk-retrospective-cohort-analysis
#3
Jonas Daugherty, Xiwu Lin, Richard Baxter, Robert Suruki, Eric Bradford
OBJECTIVE: Systemic glucocorticoids (SGCs) are a treatment option for severe asthma but are associated with the development of adverse events (AEs). Evidence on the extent of SGC use and the relationship between SGC dose and AE risk in severe asthma is limited. METHODS: Patients with severe asthma (Global Initiative for Asthma step 4/5), with no SGC use during the <6-12 months before severe asthma determination (index date) were identified in the UK-based Clinical Practice Research Datalink database (2004-2012)...
September 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28925766/correlation-of-types-of-food-and-asthma-diagnosis-in-childhood-a-case-control-study
#4
Souheil Hallit, Chantal Raherison, Rita Abou Abdallah, Rabih Hallit, Pascale Salameh
BACKGROUND: Studies concerning asthma in Lebanon investigated environmental and personal factors but none of them took into account the effect of nutritional habits. Our objective is to assess the effect of nutritional habits on asthma and allergies in Lebanese children aged between 3-16 years old. METHODS: This is a case-control study, conducted between December 2015 and April 2016. The Food Frequency Questionnaire was composed of 16 semi-quantitative questions covering different food categories...
September 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28910559/the-impact-of-fda-regulatory-activities-on-incident-dispensing-of-laba-containing-medication-2005-2011
#5
Meghan A Baker, Melissa G Butler, Sally Seymour, Fang Zhang, Yute Wu, Ann Chen Wu, Mark S Levenson, Pingsheng Wu, Aarthi Iyer, Sengwee Toh, Solomon Iyasu, Esther H Zhou
BACKGROUND: Evidence of safety issues associated with long-acting beta2-agonist (LABA) treatment has led to multiple regulatory activities by the U.S. Food and Drug Administration (FDA) on this class of medications. OBJECTIVE: This study describes the impact of the regulatory activities on incident LABA-containing medication dispensing. METHODS: A monthly rolling cohort of asthma patients who were eligible to initiate a LABA-containing product was created in the Mini-Sentinel Distributed Database between January 2005 and June 2011...
September 14, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28902527/smoking-in-the-family-is-most-predictive-of-the-development-of-childhood-asthma-in-preterm-babies-30-weeks-gestation-results-of-the-respiratory-outcomes-study-2-repos2
#6
Claire F Johnston, Margaret Broom, Bruce Shadbolt, David A Todd
OBJECTIVES: The Respiratory Outcomes Study 2 (RESPOS2) investigated the relationship between neonatal outcomes (specifically, chronic lung disease [CLD]) and environmental factors on the development of asthma and atopic outcomes at primary school age for preterm babies (PBs) <30 weeks gestational age (GA). METHODS: The study included all surviving PBs <30 weeks GA admitted to the Neonatal Intensive Care Unit at Canberra Hospital, Australian Capital Territory between 2007-2009...
September 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28892418/shared-decision-making-and-time-to-exacerbation-in-children-with-asthma
#7
Tsai-Ling Liu, Yhenneko J Taylor, Rohan Mahabaleshwarkar, Christopher M Blanchette, Hazel Tapp, Michael F Dulin
BACKGROUND: Although shared decision making (SDM) is a promising approach for improving outcomes for patients with chronic diseases, no evidence currently supports the use of SDM to delay asthma exacerbations. We evaluated the impact of an SDM intervention implemented by providers in a real-world setting on time to exacerbation in children with asthma. METHODS: This study used a prospective cohort observed between 2011-2013 at five primary care practices that serve vulnerable populations (e...
September 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28892408/variation-in-asthma-care-at-hospital-discharge-by-race-ethnicity-groups
#8
Stacy A Trent, Kohei Hasegawa, Sima K Ramratnam, Jane C Bittner, Carlos A Camargo
INTRODUCTION: While asthma disproportionately affects minorities, little is known about racial/ethnic differences in asthma care at hospital discharge. METHODS: Design: Secondary data analysis of multicenter retrospective study using standardized medical record review. POPULATION: Random sample of patients age 2-54 years, who were hospitalized for asthma at 25 hospitals from 2012-2013. Outcomes and Analysis: We categorized patients into three race/ethnicity groups: non-Hispanic white (NHW), non-Hispanic black (NHB), and Hispanic...
September 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28886264/lack-of-asthma-and-rhinitis-control-in-general-practitioner-managed-patients-prescribed-fixed-dose-combination-therapy-in-australia
#9
Sinthia Bosnic-Anticevich, Vicky Kritikos, Victoria Carter, Kwok Yin Yan, Carol Armour, Dermot Ryan, David Price
OBJECTIVES: The first aim of the study (i) assess the current asthma status of general-practitioner-managed patients receiving regular fixed-dose combination inhaled corticosteroid and long-acting beta2 agonist (FDC ICS/LABA) therapy and (ii) explore patients' perceptions of asthma control and attitudes/behaviors regarding preventer inhaler use. METHODS: A cross-sectional observational study of Australian adults with a current physician diagnosis of asthma receiving ≥2 prescriptions of FDC ICS/LABA therapy in the previous year, who were recruited through general practice to receive a structured in-depth asthma review between May 2012 and January 2014...
September 8, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28881155/seasonal-patterns-of-asthma-medication-fills-among-diverse-populations-of-the-united-states
#10
Kedir N Turi, Tebeb Gebretsadik, Rees L Lee, Tina V Hartert, Amber M Evans, Cosby Stone, Nicholas M Sicignano, Ann C Wu, Carlos Iribarren, Melissa G Butler, Edward Mitchel, James Morrow, Emma K Larkin, Pingsheng Wu
OBJECTIVE: Nonadherence to controller and overuse of reliever asthma medications are associated with exacerbations. We aimed to determine patterns of seasonal asthma medication use and to identify time period(s) during which interventions to improve medication adherence could reduce asthma morbidity. METHODS: We conducted a retrospective cohort study of asthmatics 4-50 years of age and enrolled in three diverse health insurance plans. Seasonal patterns of medications were reported by monthly prescription fill rates per 1000 individuals with asthma from 1998 to 2013, and stratified by healthcare plan, sex, and age...
September 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28881145/secondhand-tobacco-smoke-and-severity-in-wheezing-children-nasal-oxidant-stress-and-inflammation
#11
Ozge Yilmaz, Ahmet Turkeli, Ece Onur, Sema Bilge, Hasan Yuksel
OBJECTIVES: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. METHODS: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment...
September 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28872981/sex-differences-in-outcomes-after-discharge-from-alberta-emergency-departments-for-asthma-a-large-population-based-study
#12
Rhonda J Rosychuk, Maria Ospina, Jingbin Zhang, Richard Leigh, Andrew Cave, Brian H Rowe
OBJECTIVE: Asthma exacerbations frequently result in emergency department (ED) visits. While sex differences have been identified in some asthma studies, there is a paucity of literature on sex differences in the ED setting, especially population-based ones. This study examines sex differences in important outcomes of patients discharged from EDs for acute asthma in Alberta, Canada. METHODS: Alberta residents aged 2 to 55 years discharged from EDs with a primary diagnosis of asthma during 1999- 2011 were identified from administrative databases from a single-payer health care system for the entire geographic region of Alberta...
September 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28872938/laps-or-lengths-the-effects-of-different-exercise-programmes-on-asthma-control-in-children
#13
C Carew, Dw Cox
INTRODUCTION: Exercise training has been shown in numerous studies to improve lung function and asthma control in children with asthma. Swimming has been shown to be of benefit in children with asthma, but which form of exercise is better for asthmatics has not been determined to date. The aim of this study was to examine if swimming improved lung function and asthma symptoms in asthmatic children when compared with different forms of exercise and a control group. METHODS: Subjects with asthma were randomly assigned to either one of three different exercise training groups (swimming, football and basketball) or a control group...
September 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28872935/asthma-severity-and-heterogeneity-insights-from-prevalence-trends-and-associated-demographic-variables-and-anthropometric-indices-among-israeli-adolescents
#14
Yossy Machluf, Rivka Farkash, Daniel Fink, Yoram Chaiter
OBJECTIVES: While asthma presents various clinical forms with different levels of severity, it is unclear whether asthma severities are a consequence of disease management or varied etiologies. We sought to investigate this question. METHODS: This paper presents a cross-sectional study of 113,671 Israeli adolescents. Prevalence rates of mild and moderate-to-severe asthma over a 24-year period were calculated and multivariate regression models (outcomes: different asthma severity, reference: subjects without asthma) were performed to analyze associations with anthropometric indices and socio-demographic variables, in males and females separately...
September 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28872933/improving-the-asthma-disparity-gap-with-legal-advocacy-a-qualitative-study-of-patient-identified-challenges-to-improve-social-and-environmental-factors-that-contribute-to-poorly-controlled-asthma
#15
Drew A Harris, Anne Mainardi, Osatohamwen Iyamu, Marjorie S Rosenthal, R Douglas Bruce, Margaret A Pisani, Carrie A Redlich
OBJECTIVE: To identify challenges disadvantaged adults with asthma face in mitigating social and environmental factors associated with poor symptom control. METHODS: Using a community-engaged approach, we partnered with a community health center in New Haven, CT to conduct in-person interviews and a written survey of asthmatic adults with poor symptom control. Using the constant comparative method, we analyzed participant interviews to establish emerging themes and identify common barriers to improved outcomes...
September 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28858530/exploring-asthma-in-the-workplace-a-triangulation-of-perspectives-from-management-employees-and-people-with-asthma
#16
Denise H Zhao, Lorraine Smith, Bandana Saini
OBJECTIVES: People with asthma spend a significant amount of time in the workplace but little is known about the current state of disease management in such contexts. The aim of the current study is to explore the experiences, attitudes and perceptions of asthma across different stakeholders in the workplace to help inform potential recommendations for workplace asthma policies. METHODS: Using a purposive convenience sampling method, in-depth semi-structured interviews were conducted in Australia with 5 human resource personnel, 10 employees with asthma and 10 employees without asthma...
August 31, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28853959/association-between-asthma-and-falls-a-nationwide-population-based-study
#17
Jae Ho Chung, Tae Ho Kim, Chang Hoon Han
OBJECTIVES: We evaluated the relationship between asthma and falls in Koreans using data from a large population-based cross-sectional survey. METHODS: Data were obtained from 228,642 participants, of whom 6,372 had asthma, who participated in the 2013 Korean Community Health Survey. We explored the risk of falls after adjusting for sociodemographic factors and comorbidities. Logistic regression was used to identify risk factors for falls in asthmatics. Patients with asthma who had been diagnosed by a physician were included after excluding those who did not respond to the self-reported questionnaire...
August 30, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28853958/meditation-for-asthma-systematic-review-and-meta-analysis
#18
Priyamvada Paudyal, Christina Jones, Caroline Grindey, Rusha Dawood, Helen Smith
OBJECTIVE: To conduct a comprehensive review and meta-analysis of the effectiveness of meditation on a variety of asthma outcomes. METHODS: We searched MEDLINE, EMBASE, CINAHL, PsycINFO and AMED in June 2016 to identify randomised controlled trials (RCTs) investigating the effectiveness of meditation in adults with asthma. No restriction was put on language or year of publication. Study quality was assessed using The Cochrane Risk of Bias Assessment Tool. Meta-analysis was carried out using RevMan 5...
August 30, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28853957/reducing-emergency-department-visits-utilizing-a-primary-care-asthma-specialty-clinic-in-a-high-risk-patient-population
#19
Dane A Snyder, Olivia W Thomas, Sean P Gleeson, David R Stukus, LaQuita M Jones, Christopher Regan, Ashley Shamansky, Elizabeth D Allen
OBJECTIVE: Asthma is a leading cause of pediatric emergency department(ED) use. Optimizing asthma outcomes is a goal of Nationwide Children's Hospital(NCH) and its affiliated Accountable Care Organization. NCH's Primary Care Network, comprised of 12 offices serving a predominantly Medicaid population, sought to determine whether an Asthma Specialty Clinic (ASC) operated within a single primary care office could reduce ED asthma rates and improve quality measures, relative to all other network offices...
August 30, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28853952/perceptions-of-asthma-and-exercise-in-adolescents-with-and-without-asthma
#20
Winn Con, Mackintosh Ka, Eddolls Wtb, Stratton G, Wilson Am, Rance Jy, Doull Ijm, Mcnarry Ma, Davies Ga
OBJECTIVE: To elicit the views of adolescents, with and without asthma, about exercise and asthma, and the perceived benefits of and barriers to participation. The adolescent views elicited would subsequently inform the design of a high-intensity exercise intervention to improve asthma control. METHODS: Fifty-four adolescents (age 13.1±0.9years; 26 with asthma) participated in twelve semi-structured group interviews. Questions were structured around knowledge, attitudes and beliefs towards asthma and its impact on exercise participation and lifestyle...
August 30, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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