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Journal of Asthma: Official Journal of the Association for the Care of Asthma

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https://www.readbyqxmd.com/read/29106306/assessing-the-value-of-the-meaningful-use-clinical-summary-for-patients-and-families-with-pediatric-asthma
#1
Karen Colorafi, Lee Moua, Michele Shaw, David Ricker, Julie Postma
Electronic clinical summaries are innovations supported by the Electronic Health Record Incentive Program, known as "Meaningful Use" (MU). The MU clinical summary documents the shared understanding of the plan of care for patients and assists families in managing asthma-related health care. The purpose of this analysis was to identify the communicative value of the summaries to patients and families. Readability measurements, content analysis, and descriptive statistics were employed in a review of twenty clinical summaries and compared with provider encounter notes...
November 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29072971/validation-of-the-patient-completed-asthma-knowledge-questionnaire-pakq
#2
Daniel Beaurivage, Louis-Philippe Boulet, Juliet M Foster, Peter G Gibson, Vanessa M McDonald
BACKGROUND: Asthma is often suboptimally controlled, in part due to patients' disease knowledge. Understanding patients' knowledge, prior to education may help in individualizing content. However, there are no well validated or internationally relevant patient asthma knowledge questionnaires available. OBJECTIVE: To translate and validate the rigorously validated Questionnaire de connaissances sur l'asthme destiné aux patients adultes (QCA-PA) based on key points related to asthma knowledge and self-management accordingly to the Global Initiative for Asthma report...
October 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29064746/-kiss-myasthma-using-a-participatory-design-approach-to-develop-a-self-management-app-with-young-people-with-asthma
#3
S R Davis, D Peters, R A Calvo, S M Sawyer, J M Foster, L Smith
OBJECTIVE: Young people with asthma often lack engagement in self-management. Smartphone apps offer an attractive, immediate method for obtaining asthma information and self-management support. In this research we developed an evidence-based asthma app tailored to young people's needs, created using a participatory design approach to optimise user-engagement. This paper describes the participatory design process. METHODS: This multi-phased research included concept generation and ideation of app design by young people with asthma, and development of asthma information by the research team...
October 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29035608/f508del-cftr-gene-mutation-in-patients-with-allergic-bronchopulmonary-aspergillosis
#4
Maria N Gamaletsou, Gemma Hayes, Chris Harris, Joanna Brock, Eavan G Muldoon, David W Denning
OBJECTIVE: The F508del mutation occurs in approximately 3.5% of Caucasian population of Northern Europe. Heterozygotes have increased risk for asthma and reduced pulmonary function. Allergic bronchopulmonary aspergillosis (ABPA) is more common in patients with cystic fibrosis (CF). We aimed to establish the frequency of F508del mutation in adult patients with ABPA. METHODS: A retrospective matched case-control study of CF genotyped patients with ABPA seen at the National Aspergillosis Centre was undertaken...
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29035604/biomarkers-for-differentiation-of-patients-with-asthma-and-chronic-obstructive-pulmonary-disease
#5
Shigeki Katoh, Masaki Ikeda, Ryo Shirai, Masaaki Abe, Yoshihiro Ohue, Yoshihiro Kobashi, Mikio Oka
OBJECTIVE: Asthma and chronic obstructive pulmonary disease (COPD) are airflow limitation diseases with similar clinical manifestations but different pathophysiologic mechanisms. To implement the appropriate treatment, it is important to distinguish between asthma and COPD which sometimes might result difficult in clinical practice. We evaluated biomarkers to distinguish between asthma and COPD. METHODS: Blood eosinophil counts and fractional exhaled nitric oxide (FeNO) levels were analyzed...
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29035125/letter-re-reducing-emergency-department-visits-utilizing-a-primary-care-asthma-specialty-clinic-in-a-high-risk-patient-population
#6
Simon Braithwaite, Jonny Coppel, Lucy Everson, Jessica Kearney, Lucy Gibson, Rahul Chodhari
No abstract text is available yet for this article.
October 16, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29028376/interprofessional-pulmocheck-care-pathway-an-innovative-approach-to-managing-pediatric-asthma-care-in-the-netherlands
#7
J M J E Meuwissen, J Heynens, T Dauven, L Crasborn, F W J M Smeenk, T van der Weijden, J W M Muris
OBJECTIVES: Under-diagnosis and suboptimal asthma control in children persists. An innovative care pathway was developed by a hospital department of pediatrics with the aim to detect pulmonary problems in children and provide appropriate treatment possibilities through systematic feedback towards the referring primary care physician. Primary care physicians can use this pathway to refer children with asthma-like symptoms for a one-day assessment. Goals are to measure the usage of the pathway by primary care general practitioners (GPs), the outcomes in terms of new diagnoses of asthma, the reduction in regular referrals, generated recommendations/therapy and the adequacy of asthma follow-up...
October 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29027824/a-computable-phenotype-for-asthma-case-identification-in-adult-and-pediatric-patients-external-validation-in-the-chicago-area-patient-outcomes-research-network-capricorn
#8
Majid Afshar, Valerie G Press, Rachel G Robison, Abel N Kho, Sindhura Bandi, Ashvini Biswas, Pedro C Avila, Harsha Vardhan Madan Kumar, Byung Yu, Edward T Naureckas, Sharmilee M Nyenhuis, Christopher D Codispoti
OBJECTIVE: Comprehensive, rapid, and accurate identification of patients with asthma for clinical care and engagement in research efforts is needed. The original development and validation of a computable phenotype for asthma case identification occurred at a single institution in Chicago and demonstrated excellent test characteristics. However, its application in a diverse payer mix, across different health systems and multiple electronic health record vendors, and in both children and adults was not examined...
October 13, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29023174/subjective-responses-to-sprint-interval-exercise-in-adults-with-and-without-exercise-induced-bronchoconstriction
#9
Joshua Good, Shilpa Dogra
OBJECTIVE: Little is known of the subjective response to exercise that involves short "all out" bursts of effort, separated by recovery periods (sprint interval exercise (SPRINT)) among adults with exercise-induced bronchoconstriction (EIBC). The purpose of this study was to compare subjective responses to SPRINT and moderate intensity continuous exercise (MOD) among adults with EIBC, and to compare these responses between adults with EIBC and those without EIBC. METHODS: Eight adults (22...
October 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29023163/asthma-exacerbations-and-socio-economic-status-in-french-adults-with-persistent-asthma-a-prospective-cohort-study
#10
Katia Mazalovic, Flore Jacoud, Alexandra L Dima, Eric Van Ganse, Maeva Nolin, Didier C, Claire Zaba, The Astro-Lab Group
INTRODUCTION: Adults disadvantaged by poor socio-economic status (SES) are more severely affected by asthma compared to those with better SES. We aimed to determine whether the frequency of asthma exacerbations (AEx), as well as aspects related to AEx management, differed based on SES in patients treated with daily treatments. METHODS: This study, part of the prospective observational cohort ASTRO-LAB, included French adult patients with persistent asthma. Patients were considered as low SES if they benefited from publicly funded special health insurance and/or were perceived as low SES by their general practitioner...
October 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29020468/comparative-features-of-asthma-with-frequent-or-infrequent-exacerbations-a-longitudinal-study-of-retrospective-and-prospective-events
#11
Marie-Ève Boulay, Claudia Pruneau-Pomerleau, Hélène Villeneuve, Francine Deschesnes, Lyne Ringuette, Louis-Philippe Boulet
BACKGROUND: A "frequent exacerbator phenotype" has been described, mostly in the population of patients with severe asthma. Further data are needed on such exacerbation-prone patients in milder asthma. AIM: To compare the characteristics of frequent and nonfrequent exacerbators in asthma of different severities and to assess the stability of the exacerbator status. METHODS: This was an observational study comparing baseline data from frequent (≥2 exacerbations in the past year) and nonfrequent (<2 exacerbations in the past year) exacerbators...
October 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29020463/the-role-of-human-rhinovirus-hrv-species-on-asthma-exacerbation-severity-in-children-and-adolescents
#12
Katrina A Lambert, Luke A Prendergast, Shyamali C Dharmage, Mimi Tang, Molly O'Sullivan, Thomas Tran, Julian Druce, Philip Bardin, Michael J Abramson, Bircan Erbas
OBJECTIVE: It is recognized that human rhinovirus (HRV) infection is an important factor in asthma exacerbations requiring hospitalization in children. However, previous studies have disagreed on the differential impact of various HRV species. We sought to assess the impact of HRV species on the severity of asthma exacerbations in children and adolescents. We also examined whether the effect of HRV species on severity was modified by age and gender. METHODS: Virus strain was determined for 113 children with HRV detectable at the time of admission for asthma exacerbation...
October 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28991498/spontaneous-pneumomediastinum-complicating-severe-acute-asthma-exacerbation-in-adult-patients
#13
Andrea Vianello, Marco Caminati, Fulvia Chieco-Bianchi, Maria Rita Marchi, Stefania Vio, Giovanna Arcaro, Silvia Iovino, Fausto Braccioni, Beatrice Molena, Cristian Turato, Piera Peditto, Laura Battistella, Federico Gallan, Gianenrico Senna
OBJECTIVES: The real incidence of pneumomediastinum (PNM) in adult patients with severe acute asthma exacerbation continues to be unknown. The current study aims to investigate the occurrence of PNM in an adult population of patients presenting a severe asthma attack and to evaluate the risk factors associated to its development. METHODS: The 45 consecutive subjects who were admitted to our Division between January 1, 2015 and December 31, 2016 for severe acute asthma exacerbation underwent a diagnostic protocol including a standard chest X-ray and continuous monitoring of arterial oxygen saturation (SaO2) during the first 24 hours following admission...
October 9, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28981368/the-national-burden-of-poorly-controlled-asthma-school-absence-and-parental-work-loss-among-school-aged-children-in-the-united-states
#14
P W Sullivan, V Ghushchyan, P Navaratnam, H S Friedman, A Kavati, B Ortiz, B Lanier
OBJECTIVE: The degree of poorly controlled asthma and its association with missed school days and parental missed work days is not well understood. METHODS: This was a retrospective analysis of missed school days and missed work days for school-aged children (SAC; aged 6-17) and their caregivers in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). Indicators of poor asthma control included: exacerbation in previous 12 months; use of >3 canisters of short-acting beta agonist (SABA) in 3 months; and annual asthma-specific (AS) Emergency Department (ED) or inpatient (IP) visits...
October 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28976789/estimating-asthma-control-questionnaire-acq-scores-from-claims-data
#15
Patrick W Sullivan, Vahram H Ghushchyan, Gary Globe
BACKGROUND: Asthma control is the main focus of treatment guidelines. Valid instruments such as the Asthma Control Questionnaire (ACQ) require prospective survey. These surveys may be challenging for large population health applications. OBJECTIVE: To develop an algorithm for estimating ACQ-5 scores from commonly available claims data. METHODS: Data was derived from four prospective surveys including the ACQ-5 combined with retrospective claims of Kaiser Permanente of Colorado (KPCO) patients...
October 4, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28976229/associations-of-atopy-and-asthma-during-aging-of-an-adult-population-over-a-20-year-follow-up
#16
Diogenes S Ferreira, Sonia Kaushik, Catherine L Smith, Shyamali C Dharmage, Geza P Benke, Bruce R Thompson, E Haydn Walters, Rory Wolfe, Michael J Abramson
OBJECTIVE: Atopy is associated with asthma, but cross-sectional studies suggest this association may be weaker in older adults. It remains unclear if atopy predicts asthma later in adult life. We aimed to investigate whether atopy in young adults predicted asthma 20 years later and to quantify the contemporaneous relationship of atopy and asthma as adults age. METHODS: Participants of the European Community Respiratory Health Survey (ECRHS) in Melbourne aged 20-44 years were followed for 20 years and completed questionnaires, skin prick tests (SPT) and allergen specific immunoglobulin E measurement at a baseline and two subsequent surveys...
October 4, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28976222/health-related-quality-of-life-in-relation-to-asthma-data-from-a-cross-sectional-study
#17
Jae Ho Chung, Chang Hoon Han
OBJECTIVE: The aim of this study was to examine the effect of adult asthma on health-related quality of life (HRQoL) and psychological factors using the results of a cross-sectional nationwide survey. METHODS: Data were obtained from 229,131 participants (5,989 with asthma and 223,142 without asthma) in the 2010 Korean Community Health Survey. We compared EuroQol (EQ)-5D and EQ-visual analogue scale (VAS) scores after adjusting for sociodemographic and psychosocial factors, as well as for comorbidities...
October 4, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28972433/thymic-stromal-lymphopoietin-contribution-to-the-recruitment-of-circulating-fibrocytes-to-the-lung-in-a-mouse-model-of-chronic-allergic-asthma
#18
Zhuang-Gui Chen, Ping Meng, Hong-Tao Li, Ming Li, Li-Fen Yang, Yan Yan, Ya-Ting Li, Xiao-Ling Zou, De-Yun Wang, Tian-Tuo Zhang
OBJECTIVE: Fibrocyte localization to the airways and thymic stromal lymphopoietin (TSLP) overexpression in the lung are features of severe asthma. The aim of this study was to determine whether TSLP contributes to fibrocyte trafficking and airway remodeling in a mouse model of allergic asthma. METHODS: We established a chronic asthma animal model by administering house dust mite (HDM) extracts intranasally for up to 5 consecutive weeks. Mouse anti-TSLP monoclonal antibody (mAb) was given intraperitoneally starting the 4(th) week...
October 3, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28961020/once-daily-fluticasone-furoate-vilanterol-versus-twice-daily-fluticasone-propionate-salmeterol-in-patients-with-asthma-well-controlled-on-ics-laba
#19
David Bernstein, Leslie Andersen, Richard Forth, Loretta Jacques, Louisa Yates
OBJECTIVE: We aimed to demonstrate non-inferiority of once-daily fluticasone furoate/vilanterol 100/25 μg (FF/VI) to twice-daily fluticasone propionate/salmeterol 250/50 μg (FP/SAL) in adults/adolescents with asthma well controlled on inhaled corticosteroid/long-acting β2 agonist (ICS/LABA). METHODS: This was a randomized, double-blind, double-dummy, parallel-group, 24-week study (NCT02301975/GSK study 201378). Patients whose asthma met study-defined criteria for control were randomized 1:1:1 to receive FF/VI, FP/SAL or twice-daily FP 250 μg for 24 weeks...
September 29, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28960099/the-role-of-hdac2-in-cigarette-smoke-induced-airway-inflammation-in-a-murine-model-of-asthma-and-the-effect-of-intervention-with-roxithromycin
#20
Mengling Xia, Hui Xu, Wei Dai, Cong Zhu, Liqin Wu, Sunshun Yan, Xiangting Ge, Wangfeng Zhou, Cuicui Chen, Yuanrong Dai
BACKGROUND: Cigarette smoke is well known to worsen asthma symptoms in asthmatic patients and to make them refractory to treatment, but the underling molecular mechanism is unclear. We hypothesized that cigarette smoke can reduce the expression of HDAC2 in asthma and the process was achieved by activating the PI3K-δ/Akt signaling pathway. We further hypothesized that roxithromycin (RXM) can alleviate the impacts by cigarette smoke. METHODS: A murine model of asthma induced by ovalbumin (OVA) and cigarette smoke has been established...
September 29, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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