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Journal of the American Society of Nephrology: JASN

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https://www.readbyqxmd.com/read/30420422/association-of-blood-pressure-trajectories-in-early-life-with-subclinical-renal-damage-in-middle-age
#1
Wenling Zheng, Jianjun Mu, Chao Chu, Jiawen Hu, Yu Yan, Qiong Ma, Yongbo Lv, Xianjing Xu, Keke Wang, Yang Wang, Ying Deng, Bo Yan, Ruihai Yang, Jun Yang, Yong Ren, Zuyi Yuan
BACKGROUND: Although high BP is one of the most important factors affecting renal function, whether longitudinal BP trajectories in early life course are associated with renal function damage in later life is unclear. METHODS: To investigate the correlation between BP trajectories from childhood to adulthood and renal function in middle age, we used group-based trajectory models to identify BP trajectories in 2430 individuals (aged 6-15 years old at baseline) participating in the ongoing Hanzhong Adolescent Hypertension Cohort...
November 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30420421/the-long-term-impact-of-renin-angiotensin-system-ras-inhibition-on-cardiorenal-outcomes-lirico-a-randomized-controlled-trial
#2
Valeria Saglimbene, Suetonia C Palmer, Marinella Ruospo, Patrizia Natale, Ausilia Maione, Antonio Nicolucci, Mariacristina Vecchio, Gianni Tognoni, Jonathan C Craig, Fabio Pellegrini, Giuseppe Lucisano, Jörgen Hegbrant, Rosario Ariano, Olga Lamacchia, Antonio Sasso, Susanna Morano, Tiziana Filardi, Salvatore De Cosmo, Giuseppe Pugliese, Deni A Procaccini, Loreto Gesualdo, Giuseppe Palasciano, David W Johnson, Marcello Tonelli, Giovanni F M Strippoli
BACKGROUND: The comparative effectiveness of treatment with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or their combination in people with albuminuria and cardiovascular risk factors is unclear. METHODS: In a multicenter, randomized, open label, blinded end point trial, we evaluated the effectiveness on cardiovascular events of ACE or ARB monotherapy or combination therapy, targeting BP<130/80 in patients with moderate or severe albuminuria and diabetes or other cardiovascular risk factors...
November 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30420420/anticoagulant-related-nephropathy
#3
REVIEW
Sergey Brodsky, John Eikelboom, Lee A Hebert
Anticoagulant-related nephropathy (ARN) is a newly recognized form of AKI in which overanticoagulation causes profuse glomerular hemorrhage, which manifests on renal biopsy as numerous renal tubules filled with red cells and red cell casts. The glomeruli show changes, but they are not sufficient to account for the glomerular hemorrhage. We were the first to study ARN, and since then, our work has been confirmed by numerous other investigators. Oral anticoagulants have been in widespread use since the 1950s; today, >2 million patients with atrial fibrillation take an oral anticoagulant...
November 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30420419/the-terrible-toll-of-the-kidney-shortage
#4
EDITORIAL
Frank McCormick, Philip J Held, Glenn M Chertow
No abstract text is available yet for this article.
November 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30404908/financial-costs-incurred-by-living-kidney-donors-a-prospective-cohort-study
#5
Sebastian Przech, Amit X Garg, Jennifer B Arnold, Lianne Barnieh, Meaghan S Cuerden, Christine Dipchand, Liane Feldman, John S Gill, Martin Karpinski, Greg Knoll, Charmaine Lok, Matthew Miller, Mauricio Monroy, Chris Nguan, G V Ramesh Prasad, Sisira Sarma, Jessica M Sontrop, Leroy Storsley, Scott Klarenbach
BACKGROUND: Approximately 40% of the kidneys for transplant worldwide come from living donors. Despite advantages of living donor transplants, rates have stagnated in recent years. One possible barrier may be costs related to the transplant process that potential willing donors may incur for travel, parking, accommodation, and lost productivity. METHODS: To better understand and quantify the financial costs incurred by living kidney donors, we conducted a prospective cohort study, recruiting 912 living kidney donors from 12 transplant centers across Canada between 2009 and 2014; 821 of them completed all or a portion of the costing survey...
November 7, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30389728/authors-reply
#6
LETTER
Sanjeev Sethi, Vincent Rajkumar, Vivette D D'Agati
No abstract text is available yet for this article.
November 2, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30389727/evaluating-the-evidence-behind-policy-mandates-in-us-dialysis-care
#7
Kevin F Erickson, Wolfgang C Winkelmayer
No abstract text is available yet for this article.
November 2, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30389726/persistent-underrepresentation-of-kidney-disease-in-randomized-controlled-trials-of-cardiovascular-disease-in-the-contemporary-era
#8
Rohit Maini, David B Wong, Daniel Addison, Elizabeth Chiang, Steven D Weisbord, Hani Jneid
No abstract text is available yet for this article.
November 2, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30385652/health-outcome-priorities-of-older-adults-with-advanced-ckd-and-concordance-with-their-nephrology-providers-perceptions
#9
Sarah J Ramer, Natalie N McCall, Cassianne Robinson-Cohen, Edward D Siew, Huzaifah Salat, Aihua Bian, Thomas G Stewart, Maie H El-Sourady, Mohana Karlekar, Loren Lipworth, T Alp Ikizler, Khaled Abdel-Kader
BACKGROUND: Older adults with advanced CKD have significant pain, other symptoms, and disability. To help ensure that care is consistent with patients' values, nephrology providers should understand their patients' priorities when they make clinical recommendations. METHODS: Patients aged ≥60 years with advanced (stage 4 or 5) non-dialysis-dependent CKD receiving care at a CKD clinic completed a validated health outcome prioritization tool to ascertain their health outcome priorities...
November 1, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30385651/dose-dependent-effect-of-enzyme-replacement-therapy-on-neutralizing-antidrug-antibody-titers-and-clinical-outcome-in-patients-with-fabry-disease
#10
Malte Lenders, Leon Paul Neußer, Michael Rudnicki, Peter Nordbeck, Sima Canaan-Kühl, Albina Nowak, Markus Cybulla, Boris Schmitz, Jan Lukas, Christoph Wanner, Stefan-Martin Brand, Eva Brand
BACKGROUND: Use of enzyme replacement therapy (ERT) to treat Fabry disease, caused by deficient lysosomal α -galactosidase A activity, can lead to formation of neutralizing antidrug antibodies (ADAs). These antibodies are associated with increased accumulation of plasma globotriaosylceramide (Gb3) and disease progression. Because agalsidase ERT can saturate ADA-binding sites during infusions (achieving agalsidase/antibody equilibrium), we investigated in this open cohort study whether saturated patients (who have excess agalsidase after infusions) experience better clinical outcomes compared with not saturated patients (who have excess ADAs after infusions)...
November 1, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30377234/are-current-strategies-for-building-a-human-kidney-misguided-speculative-alternatives
#11
Leon G Fine
No abstract text is available yet for this article.
October 30, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30377233/smouldering-myeloma-presenting-with-renal-histopathology-of-monoclonal-gammopathy-of-renal-significance-adding-to-the-complexity
#12
LETTER
Andreas Kousios, Neill Duncan, Rawya Charif, Candice Roufosse
No abstract text is available yet for this article.
October 30, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30377232/transcription-factor-21-is-required-for-branching-morphogenesis-and-regulates-the-gdnf-axis-in-kidney-development
#13
Shintaro Ide, Gal Finer, Yoshiro Maezawa, Tuncer Onay, Tomokazu Souma, Rizaldy Scott, Kana Ide, Yoshihiro Akimoto, Chengjin Li, Minghao Ye, Xiangmin Zhao, Yusuke Baba, Takuya Minamizuka, Jing Jin, Minoru Takemoto, Koutaro Yokote, Susan E Quaggin
BACKGROUND: The mammalian kidney develops through reciprocal inductive signals between the metanephric mesenchyme and ureteric bud. Transcription factor 21 (Tcf21) is highly expressed in the metanephric mesenchyme, including Six2-expressing cap mesenchyme and Foxd1-expressing stromal mesenchyme. Tcf21 knockout mice die in the perinatal period from severe renal hypodysplasia. In humans, Tcf21 mRNA levels are reduced in renal tissue from human fetuses with renal dysplasia. The molecular mechanisms underlying these renal defects are not yet known...
October 30, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30377231/cardiovascular-events-after-new-onset-atrial-fibrillation-in-adults-with-ckd-results-from-the-chronic-renal-insufficiency-cohort-cric-study
#14
Nisha Bansal, Dawei Xie, Daohang Sha, Lawrence J Appel, Rajat Deo, Harold I Feldman, Jiang He, Kenneth Jamerson, John W Kusek, Steven Messe, Sankar D Navaneethan, Mahboob Rahman, Ana Catherine Ricardo, Elsayed Z Soliman, Raymond Townsend, Alan S Go
BACKGROUND: Atrial fibrillation (AF), the most common sustained arrhythmia in CKD, is associated with poor clinical outcomes in both patients without CKD and patients with dialysis-treated ESRD. However, less is known about AF-associated outcomes in patients with CKD who do not require dialysis. METHODS: To prospectively examine the association of new-onset AF with subsequent risks of cardiovascular disease events and death among adults with CKD, we studied participants enrolled in the Chronic Renal Insufficiency Cohort Study who did not have AF at baseline...
October 30, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30377230/genetic-analysis-of-400-patients-refines-understanding-and-implicates-a-new-gene-in-atypical-hemolytic-uremic-syndrome
#15
Fengxiao Bu, Yuzhou Zhang, Kai Wang, Nicolo Ghiringhelli Borsa, Michael B Jones, Amanda O Taylor, Erika Takanami, Nicole C Meyer, Kathy Frees, Christie P Thomas, Carla Nester, Richard J H Smith
BACKGROUND: Genetic variation in complement genes is a predisposing factor for atypical hemolytic uremic syndrome (aHUS), a life-threatening thrombotic microangiopathy, however interpreting the effects of genetic variants is challenging and often ambiguous. METHODS: We analyzed 93 complement and coagulation genes in 400 patients with aHUS, using as controls 600 healthy individuals from Iowa and 63,345 non-Finnish European individuals from the Genome Aggregation Database...
October 30, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30361326/a-high-throughput-screen-identifies-dyrk1a-inhibitor-id-8-that-stimulates-human-kidney-tubular-epithelial-cell-proliferation
#16
Maria B Monteiro, Susanne Ramm, Vidya Chandrasekaran, Sarah A Boswell, Elijah J Weber, Kevin A Lidberg, Edward J Kelly, Vishal S Vaidya
BACKGROUND: The death of epithelial cells in the proximal tubules is thought to be the primary cause of AKI, but epithelial cells that survive kidney injury have a remarkable ability to proliferate. Because proximal tubular epithelial cells play a predominant role in kidney regeneration after damage, a potential approach to treat AKI is to discover regenerative therapeutics capable of stimulating proliferation of these cells. METHODS: We conducted a high-throughput phenotypic screen using 1902 biologically active compounds to identify new molecules that promote proliferation of primary human proximal tubular epithelial cells in vitro ...
October 25, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30361325/duet-a-phase-2-study-evaluating-the-efficacy-and-safety-of-sparsentan-in-patients-with-fsgs
#17
Howard Trachtman, Peter Nelson, Sharon Adler, Kirk N Campbell, Abanti Chaudhuri, Vimal Kumar Derebail, Giovanni Gambaro, Loreto Gesualdo, Debbie S Gipson, Jonathan Hogan, Kenneth Lieberman, Brad Marder, Kevin Edward Meyers, Esmat Mustafa, Jai Radhakrishnan, Tarak Srivastava, Miganush Stepanians, Vladimír Tesar, Olga Zhdanova, Radko Komers
BACKGROUND: We evaluated and compared the effects of sparsentan, a dual endothelin type A (ETA ) and angiotensin II type 1 receptor antagonist, with those of the angiotensin II type 1 receptor antagonist irbesartan in patients with primary FSGS. METHODS: In this phase 2, randomized, double-blind, active-control Efficacy and Safety of Sparsentan (RE-021), a Dual Endothelin Receptor and Angiotensin Receptor Blocker, in Patients with Focal Segmental Glomerulosclerosis (FSGS): A Randomized, Double-blind, Active-Control, Dose-Escalation Study (DUET), patients aged 8-75 years with biopsy-proven FSGS, eGFR>30 ml/min per 1...
November 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30341150/platelet-microparticles-mediate-glomerular-endothelial-injury-in-early-diabetic-nephropathy
#18
Yang Zhang, Kun Ling Ma, Yu Xiang Gong, Gui Hua Wang, Ze Bo Hu, Liang Liu, Jian Lu, Pei Pei Chen, Chen Chen Lu, Xiong Zhong Ruan, Bi Cheng Liu
BACKGROUND: Glomerular endothelium dysfunction, which plays a crucial role in the pathogenesis of early diabetic nephropathy, might be caused by circulating metabolic abnormalities. Platelet microparticles, extracellular vesicles released from activated platelets, have recently emerged as a novel regulator of vascular dysfunction. METHODS: We studied the effects of platelet microparticles on glomerular endothelial injury in early diabetic nephropathy in rats with streptozotocin-induced diabetes and primary rat glomerular endothelial cells...
November 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30341149/shroom3-fyn-interaction-regulates-nephrin-phosphorylation-and-affects-albuminuria-in-allografts
#19
Chengguo Wei, Khadija Banu, Felipe Garzon, John M Basgen, Nimrod Philippe, Zhengzi Yi, Ruijie Liu, Jui Choudhuri, Miguel Fribourg, Tong Liu, Arun Cumpelik, Jenny Wong, Mubeen Khan, Bhaskar Das, Karen Keung, Fadi Salem, Kirk N Campbell, Lewis Kaufman, Paolo Cravedi, Weijia Zhang, Philip J O'Connell, John Cijiang He, Barbara Murphy, Madhav C Menon
BACKGROUND: We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin-binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development. METHODS: We used human data, Shroom3 knockdown podocytes, and inducible shRNA-mediated knockdown mice to study the role of Shroom3 in adult glomeruli...
November 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30314979/peroxidasin-a-novel-autoantigen-in-anti-gbm-disease
#20
EDITORIAL
Stephen P McAdoo, Charles D Pusey
No abstract text is available yet for this article.
November 2018: Journal of the American Society of Nephrology: JASN
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