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Journal of the American Society of Nephrology: JASN

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https://www.readbyqxmd.com/read/29789432/gatm-mutations-cause-a-dominant-fibrillar-conformational-disease-in-mitochondria-when-eternity-kills
#1
EDITORIAL
Pierre J Courtoy, Patrick Henriet
No abstract text is available yet for this article.
May 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29789431/clinical-and-pathology-findings-associate-consistently-with-larger-glomerular-volume
#2
Aleksandar Denic, Jerry Mathew, Venkata V Nagineni, R Houston Thompson, Bradley C Leibovich, Lilach O Lerman, John C Lieske, Mariam P Alexander, Joshua J Augustine, Walter K Kremers, Andrew D Rule
Background Glomerular volume increases when demand exceeds nephron supply, which may lead to glomerulosclerosis. It is unclear if determinants of glomerular volume are consistent between populations that differ by severity of comorbidities. Methods We studied kidney biopsy specimens from living kidney donors ( n =2453) and patients who underwent radical nephrectomy for a renal tumor ( n =780). We scanned specimen sections into high-resolution digital images, manually traced glomerular profiles, and calculated mean glomerular volumes using the Weibel-Gomez stereologic formula (separately for nonsclerosed glomeruli and globally sclerosed glomeruli)...
May 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29789430/dialysis-versus-medical-management-at-different-ages-and-levels-of-kidney-function-in-veterans-with-advanced-ckd
#3
Manjula Kurella Tamura, Manisha Desai, Kristopher I Kapphahn, I-Chun Thomas, Steven M Asch, Glenn M Chertow
Background Appropriate patient selection and optimal timing of dialysis initiation among older adults with advanced CKD are uncertain. We determined the association between dialysis versus medical management and survival at different ages and levels of kidney function. Methods We assembled a nationally representative 20% sample of United States veterans with eGFR<30 ml/min per 1.73 m2 between 2005 and 2010 ( n =73,349), with follow-up through 2012. We used an extended Cox model to determine associations among the time-varying exposures, age (<65, 65-74, 75-84, and ≥85 years), eGFR (<6, 6-<9, 9-<12, 12-<15, and 15-<29 ml/min per 1...
May 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29777021/serum-6-bromotryptophan-levels-identified-as-a-risk-factor-for-ckd-progression
#4
Adrienne Tin, Girish Nadkarni, Anne M Evans, Cheryl A Winkler, Erwin Bottinger, Casey M Rebholz, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Michael S Lipkowitz, Lawrence J Appel, Dan E Arking, Josef Coresh, Morgan E Grams
Background Metabolite levels reflect physiologic homeostasis and may serve as biomarkers of disease progression. Identifying metabolites associated with APOL1 risk alleles-genetic variants associated with CKD risk commonly present in persons of African descent-may reveal novel markers of CKD progression relevant to other populations. Methods We evaluated associations between the number of APOL1 risk alleles and 760 serum metabolites identified via untargeted profiling in participants of the African American Study of Kidney Disease and Hypertension (AASK) ( n =588; Bonferroni significance threshold P <6...
May 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29777020/diet-patterns-a-neglected-aspect-of-hemodialysis-care
#5
EDITORIAL
Alexander G Logan, Andrew Mente
No abstract text is available yet for this article.
May 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29777019/cellular-origin-and-functional-relevance-of-collagen-i-production-in-the-kidney
#6
Simone Buchtler, Alexandra Grill, Stefanie Hofmarksrichter, Petra Stöckert, Gabriela Schiechl-Brachner, Manuel Rodriguez Gomez, Sophia Neumayer, Kathrin Schmidbauer, Yvonne Talke, Barbara M Klinkhammer, Peter Boor, Alexander Medvinsky, Kerstin Renner, Hayo Castrop, Matthias Mack
Background Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the capacity to produce collagen. However, the amount of collagen produced by each of these cell types and the relevance of fibrosis to renal function are unclear. Methods We generated conditional cell type-specific collagen I knockout mice and used (reversible) unilateral ureteral obstruction and adenine-induced nephropathy to study renal fibrosis and function...
May 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29773687/the-role-of-intercalated-cell-nedd4-2-in-bp-regulation-ion-transport-and-transporter-expression
#7
Masayoshi Nanami, Truyen D Pham, Young Hee Kim, Baoli Yang, Roy L Sutliff, Olivier Staub, Janet D Klein, Karen I Lopez-Cayuqueo, Regine Chambrey, Annie Y Park, Xiaonan Wang, Vladimir Pech, Jill W Verlander, Susan M Wall
Background Nedd4-2 is an E3 ubiquitin-protein ligase that associates with transport proteins, causing their ubiquitylation, and then internalization and degradation. Previous research has suggested a correlation between Nedd4-2 and BP. In this study, we explored the effect of intercalated cell (IC) Nedd4-2 gene ablation on IC transporter abundance and function and on BP. Methods We generated IC Nedd4-2 knockout mice using Cre-lox technology and produced global pendrin/ Nedd4-2 null mice by breeding global Nedd4-2 null ( Nedd4-2-/- ) mice with global pendrin null ( Slc26a4-/- ) mice...
May 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29769229/the-underestimated-burden-of-monogenic-diseases-in-adult-onset-esrd
#8
EDITORIAL
Emilie Cornec-Le Gall, Peter C Harris
No abstract text is available yet for this article.
May 16, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29764921/fibroblast-growth-factor-23-and-risks-of-cardiovascular-and-noncardiovascular-diseases-a-meta-analysis
#9
Amarnath Marthi, Killian Donovan, Richard Haynes, David C Wheeler, Colin Baigent, Christopher M Rooney, Martin J Landray, Sharon M Moe, Jun Yang, Lisa Holland, Romina di Giuseppe, Annet Bouma-de Krijger, Borislava Mihaylova, William G Herrington
Background Fibroblast growth factor-23 (FGF-23) has been hypothesized to play a role in the increased risk of cardiovascular disease in patients with CKD. Methods We identified prospective studies reporting associations between FGF-23 concentration and risk of cardiovascular events. Maximally adjusted risk ratios (RRs) were extracted for each outcome and scaled to a comparison of the top versus bottom third of the baseline FGF-23 concentration, and the results aggregated. Results Depending on the assay used, median FGF-23 concentrations were 43-74 RU/ml and 38-47 pg/ml in 17 general population cohorts; 102-392 RU/ml in nine cohorts of patients with CKD not requiring dialysis; and 79-4212 RU/ml and 2526-5555 pg/ml in eight cohorts of patients on dialysis...
May 15, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29764920/right-heart-failure-unrecognized-cause-of-cardiorenal-syndrome
#10
Shweta Bansal, Anand Prasad, Stuart Linas
No abstract text is available yet for this article.
May 15, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29752413/everolimus-with-reduced-calcineurin-inhibitor-exposure-in-renal-transplantation
#11
Julio Pascual, Stefan P Berger, Oliver Witzke, Helio Tedesco, Shamkant Mulgaonkar, Yasir Qazi, Steven Chadban, Federico Oppenheimer, Claudia Sommerer, Rainer Oberbauer, Yoshihiko Watarai, Christophe Legendre, Franco Citterio, Mitchell Henry, Titte R Srinivas, Wen-Lin Luo, AnaMaria Marti, Peter Bernhardt, Flavio Vincenti
Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the efficacy and safety outcomes of this treatment after kidney transplant require confirmation. Methods In a multicenter noninferiority trial, we randomized 2037 de novo kidney transplant recipients to receive, in combination with induction therapy and corticosteroids, everolimus with reduced-exposure CNI (everolimus arm) or mycophenolic acid (MPA) with standard-exposure CNI (MPA arm). The primary end point was treated biopsy-proven acute rejection or eGFR<50 ml/min per 1...
May 11, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29748329/oral-antibiotic-exposure-and-kidney-stone-disease
#12
Gregory E Tasian, Thomas Jemielita, David S Goldfarb, Lawrence Copelovitch, Jeffrey S Gerber, Qufei Wu, Michelle R Denburg
Background Although intestinal and urinary microbiome perturbations are associated with nephrolithiasis, whether antibiotics are a risk factor for this condition remains unknown. Methods We determined the association between 12 classes of oral antibiotics and nephrolithiasis in a population-based, case-control study nested within 641 general practices providing electronic health record data for >13 million children and adults from 1994 to 2015 in the United Kingdom. We used incidence density sampling to match 25,981 patients with nephrolithiasis to 259,797 controls by age, sex, and practice at date of diagnosis (index date)...
May 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29748328/does-the-receipt-of-antibiotics-for-common-infectious-diseases-predispose-to-kidney-stones-a-cautionary-note-for-all-health-care-practitioners
#13
Lama Nazzal, Martin J Blaser
No abstract text is available yet for this article.
May 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29748327/vascularizing-the-kidney-in-the-embryo-and-organoid-questioning-assumptions-about-renal-vasculogenesis
#14
David A D Munro, Jamie A Davies
No abstract text is available yet for this article.
May 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29748326/a-novel-method-for-rapid-bedside-measurement-of-gfr
#15
Dana V Rizk, Daniel Meier, Ruben M Sandoval, Teresa Chacana, Erinn S Reilly, Jesse C Seegmiller, Emmanuel DeNoia, James S Strickland, Joseph Muldoon, Bruce A Molitoris
Background Direct quantitative measurement of GFR (mGFR) remains a specialized task primarily performed in research settings. Multiple formulas for estimating GFR have been developed that use the readily available endogenous biomarkers creatinine and/or cystatin C. However, eGFR formulas have limitations, and an accurate mGFR is necessary in some clinical situations and for certain patient populations. We conducted a prospective, open-label study to evaluate a novel rapid technique for determining plasma volume and mGFR...
May 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29739813/interleukin-1-%C3%AE-activates-a-myc-dependent-metabolic-switch-in-kidney-stromal-cells-necessary-for-progressive-tubulointerstitial-fibrosis
#16
Dario R Lemos, Michael McMurdo, Gamze Karaca, Julia Wilflingseder, Irina A Leaf, Navin Gupta, Tomoya Miyoshi, Koichiro Susa, Bryce G Johnson, Kirolous Soliman, Guanghai Wang, Ryuji Morizane, Joseph V Bonventre, Jeremy S Duffield
Background Kidney injury is characterized by persisting inflammation and fibrosis, yet mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined. Methods RNA sequencing of fibrotic kidneys from patients with CKD identified a metabolic gene signature comprising loss of mitochondrial and oxidative phosphorylation gene expression with a concomitant increase in regulators and enzymes of glycolysis under the control of PGC1 α and MYC transcription factors, respectively. We modeled this metabolic switch in vivo , in experimental murine models of kidney injury, and in vitro in human kidney stromal cells (SCs) and human kidney organoids...
May 8, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29728422/residual-function-effectively-controls-plasma-concentrations-of-secreted-solutes-in-patients-on-twice-weekly-hemodialysis
#17
Sheldon C Leong, Justin N Sao, Abigail Taussig, Natalie S Plummer, Timothy W Meyer, Tammy L Sirich
Background Most patients on hemodialysis are treated thrice weekly even if they have residual kidney function, in part because uncertainty remains as to how residual function should be valued and incorporated into the dialysis prescription. Recent guidelines, however, have increased the weight assigned to residual function and thus reduced the treatment time required when it is present. Increasing the weight assigned to residual function may be justified by knowledge that the native kidney performs functions not replicated by dialysis, including solute removal by secretion...
May 4, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29724883/metabolomics-research-in-chronic-kidney-disease
#18
Morgan E Grams, Tariq Shafi, Eugene P Rhee
No abstract text is available yet for this article.
May 3, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29724882/protein-mass-spectrometry-made-simple
#19
Jon B Klein, Mark A Knepper
No abstract text is available yet for this article.
May 3, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29720549/the-role-of-palladin-in-podocytes
#20
Nadine Artelt, Tim A Ludwig, Henrik Rogge, Panagiotis Kavvadas, Florian Siegerist, Antje Blumenthal, Jens van den Brandt, Carol A Otey, Marie-Louise Bang, Kerstin Amann, Christos E Chadjichristos, Christos Chatziantoniou, Karlhans Endlich, Nicole Endlich
Background Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration barrier and ESRD. Because the complex three-dimensional morphology of podocytes depends on the actin cytoskeleton, we studied the role in podocytes of the actin bundling protein palladin, which is highly expressed therein. Methods We knocked down palladin in cultured podocytes by siRNA transfection or in zebrafish embryos by morpholino injection and studied the effects by immunofluorescence and live imaging...
May 2, 2018: Journal of the American Society of Nephrology: JASN
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