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Journal of the American Society of Nephrology: JASN

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https://www.readbyqxmd.com/read/30228151/kidney-transplantation-rates-of-veterans-administration-listed-patients-compared-with-rates-of-patients-on-nonveteran-lists
#1
EDITORIAL
Mohan Ramkumar, Susan T Crowley
No abstract text is available yet for this article.
September 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30228150/a-practical-guide-for-treatment-of-rapidly-progressive-adpkd-with-tolvaptan
#2
REVIEW
Fouad T Chebib, Ronald D Perrone, Arlene B Chapman, Neera K Dahl, Peter C Harris, Michal Mrug, Reem A Mustafa, Anjay Rastogi, Terry Watnick, Alan S L Yu, Vicente E Torres
In the past, the treatment of autosomal dominant polycystic kidney disease (ADPKD) has been limited to the management of its symptoms and complications. Recently, the US Food and Drug Administration (FDA) approved tolvaptan as the first drug treatment to slow kidney function decline in adults at risk of rapidly progressing ADPKD. Full prescribing information approved by the FDA provides helpful guidelines but does not address practical questions that are being raised by nephrologists, internists, and general practitioners taking care of patients with ADPKD, and by the patients themselves...
September 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30217807/genetic-variants-associated-with-circulating-fibroblast-growth-factor-23
#3
Cassianne Robinson-Cohen, Traci M Bartz, Dongbing Lai, T Alp Ikizler, Munro Peacock, Erik A Imel, Erin D Michos, Tatiana M Foroud, Kristina Akesson, Kent D Taylor, Linnea Malmgren, Kunihiro Matsushita, Maria Nethander, Joel Eriksson, Claes Ohlsson, Daniel Mellström, Myles Wolf, Osten Ljunggren, Fiona McGuigan, Jerome I Rotter, Magnus Karlsson, Michael J Econs, Joachim H Ix, Pamela L Lutsey, Bruce M Psaty, Ian H de Boer, Bryan R Kestenbaum
BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences. METHODS: We performed a meta-analysis of genome-wide association studies of circulating FGF23 concentrations among 16,624 participants of European ancestry from seven cohort studies, excluding participants with eGFR<30 ml/min per 1...
September 14, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30209078/mcp1-promotes-macrophage-dependent-cyst-expansion-in-autosomal-dominant-polycystic-kidney-disease
#4
Marcelo F Cassini, Vijayakumar R Kakade, Elizabeth Kurtz, Parker Sulkowski, Peter Glazer, Richard Torres, Stefan Somlo, Lloyd G Cantley
BACKGROUND: In patients with autosomal dominant polycystic kidney disease (ADPKD), most of whom have a mutation in PKD1 or PKD2 , abnormally large numbers of macrophages accumulate around kidney cysts and promote their growth. Research by us and others has suggested that monocyte chemoattractant protein-1 (Mcp1) may be a signal for macrophage-mediated cyst growth. METHODS: To define the role of Mcp1 and macrophages in promoting cyst growth, we used mice with inducible knockout of Pkd1 alone (single knockout) or knockout of both Pkd1 and Mcp1 (double knockout) in the murine renal tubule...
September 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30209077/are-cyst-associated-macrophages-in-polycystic-kidney-disease-the-equivalent-to-tams-in-cancer
#5
EDITORIAL
Thomas Weimbs
No abstract text is available yet for this article.
September 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30206142/hereditary-kidney-disease-all-family-members-are-affected
#6
Roberta M Falke, Andrew S Levey
No abstract text is available yet for this article.
September 11, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30206141/assessment-of-perfusion-and-oxygenation-of-the-human-renal-cortex-and-medulla-by-quantitative-mri-during-handgrip-exercise
#7
Bryan Thomas Haddock, Susan T Francis, Henrik B W Larsson, Ulrik B Andersen
BACKGROUND: Renal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity. METHODS: To monitor medullary and cortical oxygenation under handgrip exercise-reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise...
September 11, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30185470/perspective-will-we-ever-know-the-optimal-hgb-level-in-esrd
#8
Jay B Wish
No abstract text is available yet for this article.
September 5, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30185469/the-absence-of-the-ace-n-domain-decreases-renal-inflammation-and-facilitates-sodium-excretion-during-diabetic-kidney-disease
#9
Masahiro Eriguchi, Ellen A Bernstein, Luciana C Veiras, Zakir Khan, Duo Yao Cao, Sebastien Fuchs, Alicia A McDonough, Jorge E Toblli, Romer A Gonzalez-Villalobos, Kenneth E Bernstein, Jorge F Giani
BACKGROUND: Recent evidence emphasizes the critical role of inflammation in the development of diabetic nephropathy. Angiotensin-converting enzyme (ACE) plays an active role in regulating the renal inflammatory response associated with diabetes. Studies have also shown that ACE has roles in inflammation and the immune response that are independent of angiotensin II. ACE's two catalytically independent domains, the N- and C-domains, can process a variety of substrates other than angiotensin I...
September 5, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30185468/human-specific-abnormal-alternative-splicing-of-wild-type-pkd1-induces-premature-termination-of-polycystin-1
#10
Wendy A Lea, Stephen C Parnell, Darren P Wallace, James P Calvet, Lesya V Zelenchuk, Nehemiah S Alvarez, Christopher J Ward
BACKGROUND: The major form of autosomal dominant polycystic kidney disease is caused by heterozygous mutations in PKD1 , the gene that encodes polycystin-1 (PC1). Unlike PKD1 genes in the mouse and most other mammals, human PKD1 is unusual in that it contains two long polypyrimidine tracts in introns 21 and 22 (2.5 kbp and 602 bp, respectively; 97% cytosine and thymine). Although these polypyrimidine tracts have been shown to form thermodynamically stable segments of triplex DNA that can cause DNA polymerase stalling and enhance the local mutation rate, the efficiency of transcription and splicing across these cytosine- and thymine-rich introns has been unexplored...
September 5, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30185467/in-center-hemodialysis-time-for-a-paradigm-shift
#11
Ambreen Gul, Dana C Miskulin, Antonia Harford, Philip Zager
No abstract text is available yet for this article.
September 5, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30143559/podocyte-specific-induction-of-kr%C3%A3-ppel-like-factor-15-restores-differentiation-markers-and-attenuates-kidney-injury-in-proteinuric-kidney-disease
#12
Yiqing Guo, Jesse Pace, Zhengzhe Li, Avi Ma'ayan, Zichen Wang, Monica P Revelo, Edward Chen, Xiangchen Gu, Ahmed Attalah, Yaqi Yang, Chelsea Estrada, Vincent W Yang, John C He, Sandeep K Mallipattu
BACKGROUND: Podocyte injury is the hallmark of proteinuric kidney diseases, such as FSGS and minimal change disease, and destabilization of the podocyte's actin cytoskeleton contributes to podocyte dysfunction in many of these conditions. Although agents, such as glucocorticoids and cyclosporin, stabilize the actin cytoskeleton, systemic toxicity hinders chronic use. We previously showed that loss of the kidney-enriched zinc finger transcription factor Krüppel-like factor 15 (KLF15) increases susceptibility to proteinuric kidney disease and attenuates the salutary effects of retinoic acid and glucocorticoids in the podocyte...
August 24, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30135240/prevalence-estimates-of-polycystic-kidney-and-liver-disease-by-population-sequencing
#13
Matthew B Lanktree, Amirreza Haghighi, Elsa Guiard, Ioan-Andrei Iliuta, Xuewen Song, Peter C Harris, Andrew D Paterson, York Pei
BACKGROUND: Estimating the prevalence of autosomal dominant polycystic kidney disease (ADPKD) is challenging because of age-dependent penetrance and incomplete clinical ascertainment. Early studies estimated the lifetime risk of ADPKD to be about one per 1000 in the general population, whereas recent epidemiologic studies report a point prevalence of three to five cases per 10,000 in the general population. METHODS: To measure the frequency of high-confidence mutations presumed to be causative in ADPKD and autosomal dominant polycystic liver disease (ADPLD) and estimate lifetime ADPKD prevalence, we used two large, population sequencing databases, gnomAD (15,496 whole-genome sequences; 123,136 exome sequences) and BRAVO (62,784 whole-genome sequences)...
August 22, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30120108/racial-disparities-in-nephrology-consultation-and-disease-progression-among-veterans-with-ckd-an-observational-cohort-study
#14
Jonathan Suarez, Jordana B Cohen, Vishnu Potluri, Wei Yang, David E Kaplan, Marina Serper, Siddharth P Shah, Peter Philip Reese
BACKGROUND: Incident rates of ESRD are much higher among black and Hispanic patients than white patients. Access to nephrology care before progression to ESRD is associated with better clinical outcomes among patients with CKD. However, it is unknown whether black or Hispanic patients with CKD experience lower pre-ESRD nephrology consultation rates compared with their white counterparts, or whether such a disparity contributes to worse outcomes among minorities. METHODS: We assembled a retrospective cohort of patients with CKD who received care through the Veterans Health Administration from 2003 to 2015, focusing on individuals with incident CKD stage 4 who had an initial eGFR≥60 ml/min per 1...
August 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30097458/mechanism-of-fibrosis-in-hnf1b-related-autosomal-dominant-tubulointerstitial-kidney-disease
#15
Siu Chiu Chan, Ying Zhang, Annie Shao, Svetlana Avdulov, Jeremy Herrera, Karam Aboudehen, Marco Pontoglio, Peter Igarashi
BACKGROUND: Mutation of HNF1B , the gene encoding transcription factor HNF-1 β , is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal function. HNF-1 β has also been implicated in epithelial-mesenchymal transition (EMT) pathways, and sustained EMT is associated with tissue fibrosis. The mechanism whereby mutated HNF1B leads to tubulointerstitial fibrosis is not known. METHODS: To explore the mechanism of fibrosis, we created HNF-1 β -deficient mIMCD3 renal epithelial cells, used RNA-sequencing analysis to reveal differentially expressed genes in wild-type and HNF-1 β -deficient mIMCD3 cells, and performed cell lineage analysis in HNF-1 β mutant mice...
August 10, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30093457/fibroblast-growth-factor-23-may-follow-cardiovascular-disease-rather-than-causing-it-in-chronic-kidney-disease
#16
LETTER
Chenchen Zhou, Changlin Mei, Bing Dai, Cheng Xue
No abstract text is available yet for this article.
August 9, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30049682/microrna-214-3p-in-the-kidney-contributes-to-the-development-of-hypertension
#17
Yong Liu, Kristie Usa, Feng Wang, Pengyuan Liu, Aron M Geurts, Junhui Li, Anna Marie Williams, Kevin R Regner, Yiwei Kong, Han Liu, Jing Nie, Mingyu Liang
BACKGROUND: In spite of extensive study, the mechanisms for salt sensitivity of BP in humans and rodent models remain poorly understood. Several microRNAs (miRNAs) have been associated with hypertension, but few have been shown to contribute to its development. METHODS: We examined miRNA expression profiles in human kidney biopsy samples and rat models using small RNA deep sequencing. To inhibit an miRNA specifically in the kidney in conscious, freely moving rats, we placed indwelling catheters to allow both renal interstitial administration of a specific anti-miR and measurement of BP...
July 26, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30006419/significantly-lower-rates-of-kidney-transplantation-among-candidates-listed-with-the-veterans-administration-a-national-and-local-comparison
#18
Joshua J Augustine, Susana Arrigain, Krishna Balabhadrapatruni, Niraj Desai, Jesse D Schold
BACKGROUND: The process for evaluating kidney transplant candidates and applicable centers is distinct for patients with Veterans Administration (VA) coverage. We compared transplant rates between candidates on the kidney waiting list with VA coverage and those with other primary insurance. METHODS: Using the Scientific Registry of Transplant Recipients database, we obtained data for all adult patients in the United States listed for a primary solitary kidney transplant between January 2004 and August 2016...
July 13, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30006418/authors-reply
#19
LETTER
William G Herrington, Killian Donovan, Borislava Mihaylova
No abstract text is available yet for this article.
July 13, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30006416/fibroblast-growth-factor-23-is-not-a-single-bystander-in-chronic-kidney-disease-mortality
#20
LETTER
Solenne Pelletier, Denis Fouque
No abstract text is available yet for this article.
July 13, 2018: Journal of the American Society of Nephrology: JASN
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