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Journal of the American Society of Nephrology: JASN

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https://www.readbyqxmd.com/read/30635375/manipulation-of-nephron-patterning-signals-enables-selective-induction-of-podocytes-from-human-pluripotent-stem-cells
#1
Yasuhiro Yoshimura, Atsuhiro Taguchi, Shunsuke Tanigawa, Junji Yatsuda, Tomomi Kamba, Satoru Takahashi, Hidetake Kurihara, Masashi Mukoyama, Ryuichi Nishinakamura
BACKGROUND: Previous research has elucidated the signals required to induce nephron progenitor cells (NPCs) from pluripotent stem cells (PSCs), enabling the generation of kidney organoids. However, selectively controlling differentiation of NPCs to podocytes has been a challenge. METHODS: We investigated the effects of various growth factors in cultured mouse embryonic NPCs during three distinct steps of nephron patterning: from NPC to pretubular aggregate, from the latter to epithelial renal vesicle (RV), and from RV to podocyte...
January 11, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30635374/producing-purer-podocytes
#2
EDITORIAL
Benjamin S Freedman
No abstract text is available yet for this article.
January 11, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30635373/hepatocyte-growth-factor-secreting-mesothelial-cell-sheets-suppress-progressive-fibrosis-in-a-rat-model-of-ckd
#3
Masatoshi Oka, Sachiko Sekiya, Ryoichi Sakiyama, Tatsuya Shimizu, Kosaku Nitta
BACKGROUND: Although hepatocyte growth factor (HGF) has antifibrotic effects and is involved in angiogenesis and vasodilation, systemic administration of HGF to prevent kidney fibrosis is not a feasible strategy for suppressing interstitial fibrosis in patients with CKD. METHODS: We investigated a novel therapy involving HGF transgenic cell sheets grown in culture from human mesothelial cells and administered to rats with unilateral ureteral obstruction (UUO). We compared progression of fibrosis in rats with UUO that received one of five interventions: HGF-transgenic mesothelial cell sheets transplanted to the kidney surface, HGF-transgenic mesothelial cell sheets transplanted to thigh, mesotherial cell sheets transplanted to kidney, no sheets, or HGF injections...
January 11, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30635372/new-insights-into-the-mechanism-of-no-3-selectivity-in-the-human-kidney-chloride-channel-clc-ka-and-the-clc-protein-family
#4
Laura Lagostena, Giovanni Zifarelli, Alessandra Picollo
BACKGROUND: The mechanism of anion selectivity in the human kidney chloride channels ClC-Ka and ClC-Kb is unknown. However, it has been thought to be very similar to that of other channels and antiporters of the CLC protein family, and to rely on anions interacting with a conserved Ser residue (Sercen ) at the center of three anion binding sites in the permeation pathway Scen . In both CLC channels and antiporters, mutations of Sercen alter the anion selectivity. Structurally, the side chain of Sercen of CLC channels and antiporters typically projects into the pore and coordinates the anion bound at Scen ...
January 11, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30622155/activation-and-proliferation-of-pd-1-kidney-double-negative-t-cells-is-dependent-on-nonclassical-mhc-proteins-and-il-2
#5
Mohanraj Sadasivam, Sanjeev Noel, Sul A Lee, Jing Gong, Mohamad E Allaf, Phillip Pierorazio, Hamid Rabb, Abdel Rahim A Hamad
BACKGROUND: CD4- CD8- double-negative (DN) αβ T cells with innate-like properties represent a significant component of T cells in human and mouse kidneys. They spontaneously proliferate in the steady state and protect against ischemic AKI. However, the mechanisms regulating DN T cell homeostasis and responses to external danger signals from "sterile" inflammation remain poorly understood. METHODS: We used knockout mice, functional assays, and an established ischemic AKI model to investigate the role of various MHC class I and II molecules in regulating kidney DN T cells...
January 8, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30622154/il-34-dependent-intrarenal-and-systemic-mechanisms-promote-lupus-nephritis-in-mrl-fas-lpr-mice
#6
Yukihiro Wada, Hilda M Gonzalez-Sanchez, Julia Weinmann-Menke, Yasunori Iwata, Amrendra K Ajay, Myriam Meineck, Vicki R Kelley
BACKGROUND: In people with SLE and in the MRL- Faslpr lupus mouse model, macrophages and autoantibodies are central to lupus nephritis. IL-34 mediates macrophage survival and proliferation, is expressed by tubular epithelial cells (TECs), and binds to the cFMS receptor on macrophages and to a newly identified second receptor, PTPRZ. METHODS: To investigate whether IL-34-dependent intrarenal and systemic mechanisms promote lupus nephritis, we compared lupus nephritis and systemic illness in MRL- Faslpr mice expressing IL-34 and IL-34 knockout (KO) MRL- Faslpr mice...
January 8, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30606785/lipid-peroxidation-drives-renal-cyst-growth-in-vitro-through-activation-of-tmem16a
#7
Rainer Schreiber, Björn Buchholz, Andre Kraus, Gunnar Schley, Julia Scholz, Jiraporn Ousingsawat, Karl Kunzelmann
BACKGROUND: Transepithelial chloride- secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. However, mechanisms for channel activation in PKD remain obscure. METHODS: Using tissue samples from patients with autosomal dominant PKD, embryonic kidney cultures, and an MDCK in vitro cyst model, we assessed peroxidation of plasma membrane phospholipids in human and mouse polycystic kidneys...
January 3, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30606784/a-randomized-trial-of-zoledronic-acid-to-prevent-bone-loss-in-the-first-year-after-kidney-transplantation
#8
Igor Denizarde Bacelar Marques, Maria Júlia Correia Lima Nepomuceno Araújo, Fabiana Giorgetti Graciolli, Luciene Machado Dos Reis, Rosa Maria R Pereira, Jackeline C Alvarenga, Melani Ribeiro Custódio, Vanda Jorgetti, Rosilene Motta Elias, Rosa Maria Affonso Moysés, Elias David-Neto
BACKGROUND: Bone and mineral disorders commonly affect kidney transplant (KTx) recipients and have been associated with a high risk of fracture. Bisphosphonates may prevent or treat bone loss in such patients, but there is concern that these drugs might induce adynamic bone disease (ABD). METHODS: In an open label, randomized trial to assess the safety and efficacy of zoledronate for preventing bone loss in the first year after kidney transplant, we randomized 34 patients before transplant to receive zoledronate or no treatment...
January 3, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30606783/readmissions-metrics-in-hemodialysis-do-the-specifics-matter
#9
EDITORIAL
Taimur Dad, Daniel E Weiner
No abstract text is available yet for this article.
January 3, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30606782/prior-hospitalization-burden-and-the-relatedness-of-30-day-readmissions-in-patients-receiving-hemodialysis
#10
Eugene Lin, Jay Bhattacharya, Glenn M Chertow
BACKGROUND: Thirty-day readmissions are common in patients receiving hemodialysis and costly to Medicare. Because patients on hemodialysis have a high background hospitalization rate, 30-day readmissions might be less likely related to the index hospitalization than in patients with other conditions. METHODS: In adults with Medicare receiving hemodialysis in the United States, we used multinomial logistic regression to evaluate whether prior hospitalization burden was associated with increased 30-day readmissions unrelated to index hospitalizations with a discharge date from January 1, 2013 to December 31, 2014...
January 3, 2019: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30573638/nucleophosmin-phosphorylation-as-a-diagnostic-and-therapeutic-target-for-ischemic-aki
#11
Zhiyong Wang, Erdjan Salih, Chinaemere Igwebuike, Ryan Mulhern, Ramon G Bonegio, Andrea Havasi, Steven C Borkan
Background Ischemic AKI lacks a urinary marker for early diagnosis and an effective therapy. Differential nucleophosmin (NPM) phosphorylation is a potential early marker of ischemic renal cell injury and a therapeutic target. Methods Differential NPM phosphorylation was assessed by mass spectrometry in NPM harvested from murine and human primary renal epithelial cells, fresh kidney tissue, and urine before and after ischemic injury. The biologic behavior and toxicity of NPM was assessed using phospho-NPM mutant proteins that either mimic stress-induced or normal NPM phosphorylation...
December 20, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30573637/improving-clinical-outcomes-in-the-era-of-information-ubiquity
#12
Robert M Califf
No abstract text is available yet for this article.
December 20, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30563915/simple-postoperative-aki-risk-spark-classification-before-noncardiac-surgery-a-prediction-index-development-study-with-external-validation
#13
Sehoon Park, Hyunjeong Cho, Seokwoo Park, Soojin Lee, Kwangsoo Kim, Hyung Jin Yoon, Jiwon Park, Yunhee Choi, Suehyun Lee, Ju Han Kim, Sejoong Kim, Ho Jun Chin, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
BACKGROUND: Researchers have suggested models to predict the risk of postoperative AKI (PO-AKI), but an externally validated risk index that can be practically implemented before patients undergo noncardiac surgery is needed. METHODS: We performed a retrospective observational study of patients without preexisting renal failure who underwent a noncardiac operation (≥1 hour) at two tertiary hospitals in Korea. We fitted a proportional odds model for an ordinal outcome consisting of three categories: critical AKI (defined as Kidney Disease Improving Global Outcomes AKI stage ≥2, post-AKI death, or dialysis within 90 days after surgery), low-stage AKI (defined as PO-AKI events not fulfilling the definition of critical AKI), and no PO-AKI...
December 18, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30559145/growth-of-the-eskd-population-progress-or-peril
#14
EDITORIAL
Allan J Collins
No abstract text is available yet for this article.
December 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30559144/kir4-1-kir5-1-activity-is-essential-for-dietary-sodium-intake-induced-modulation-of-na-cl-cotransporter
#15
Peng Wu, Zhong-Xiuzi Gao, Xiao-Tong Su, Ming-Xiao Wang, Wen-Hui Wang, Dao-Hong Lin
BACKGROUND: Dietary sodium intake regulates the thiazide-sensitive Na-Cl cotransporter (NCC) in the distal convoluted tubule (DCT). Whether the basolateral, inwardly rectifying potassium channel Kir4.1/Kir5.1 (a heterotetramer of Kir4.1/Kir5.1) in the DCT is essential for mediating the effect of dietary sodium intake on NCC activity is unknown. METHODS: We used electrophysiology, renal clearance techniques, and immunoblotting to examine effects of Kir4.1/Kir5.1 in the DCT and NCC in wild-type and kidney-specific Kir4...
December 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30559143/projecting-esrd-incidence-and-prevalence-in-the-united-states-through-2030
#16
Keith P McCullough, Hal Morgenstern, Rajiv Saran, William H Herman, Bruce M Robinson
BACKGROUND: Population rates of obesity, hypertension, diabetes, age, and race can be used in simulation models to develop projections of ESRD incidence and prevalence. Such projections can inform long-range planning for ESRD resources needs. METHODS: We used an open compartmental simulation model to estimate the incidence and prevalence of ESRD in the United States through 2030 on the basis of wide-ranging projections of population obesity and ESRD death rates...
December 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30545984/expression-profiling-of-fibroblasts-in-chronic-and-acute-disease-models-reveals-novel-pathways-in-kidney-fibrosis
#17
Atsuko Y Higashi, Bruce J Aronow, Gregory R Dressler
BACKGROUND: Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a process that includes a decrease in the number of myofibroblasts in the interstitium and degradation of the accumulated extracellular matrix, leaving little evidence of prior injury. METHODS: To investigate whether activated fibroblasts demonstrate changes in gene expression that correspond with regression after acute injury but are not observed in chronic models of fibrosis, we used microarrays to analyze gene expression patterns among fibroblast populations at different stages of injury or repair...
December 13, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30545983/the-quality-of-reporting-of-kidney-research-a-challenge-to-jasn
#18
EDITORIAL
Josephine P Briggs
No abstract text is available yet for this article.
December 13, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30545982/quantity-and-reporting-quality-of-kidney-research
#19
Markos Kyriakos Tomidis Chatzimanouil, Louise Wilkens, Hans-Joachim Anders
BACKGROUND: In 2004, researchers reported that the number of nephrology clinical trials was low and that the reporting quality of such trials was suboptimal. Furthermore, the number or quality of preclinical kidney-related studies has not been systematically evaluated. METHODS: We performed a systematic review of randomized clinical trials published in 1966-2017 (listed in the Cochrane Library) and preclinical studies published in 1945-2017 (listed in PubMed). For reporting quality analysis, we evaluated the final main paper of 118 clinical trial reports and 135 preclinical studies published in leading journals in 1996, 2006, and 2016 on the basis of criteria from the widely used CONSORT and ARRIVE guidelines...
December 13, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/30530834/the-mek-inhibitor-trametinib-ameliorates-kidney-fibrosis-by-suppressing-erk1-2-and-mtorc1-signaling
#20
Petros Andrikopoulos, Julius Kieswich, Sabrina Pacheco, Luxme Nadarajah, Steven Michael Harwood, Caroline E O'Riordan, Christoph Thiemermann, Muhammad M Yaqoob
BACKGROUND: During kidney fibrosis, a hallmark and promoter of CKD (regardless of the underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) pathway, is activated and has been implicated in the detrimental differentiation and expansion of kidney fibroblasts. An ERK1/2 pathway inhibitor, trametinib, is currently used in the treatment of melanoma, but its efficacy in the setting of CKD and renal fibrosis has not been explored. METHODS: We investigated whether trametinib has antifibrotic effects in two mouse models of renal fibrosis-mice subjected to unilateral ureteral obstruction (UUO) or fed an adenine-rich diet-as well as in cultured primary human fibroblasts...
December 10, 2018: Journal of the American Society of Nephrology: JASN
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