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Journal of the American College of Cardiology

https://read.qxmd.com/read/38530687/the-natural-history-of-atrial-functional-mitral-regurgitation
#1
JOURNAL ARTICLE
Jwan A Naser, Francisco B Alexandrino, Tomonari Harada, Hector I Michelena, Barry A Borlaug, Mackram F Eleid, Grace Lin, Christopher Scott, Austin M Kennedy, Patricia A Pellikka, Vuyisile T Nkomo, Sorin V Pislaru
BACKGROUND: The natural history of moderate/severe atrial functional mitral regurgitation (AFMR) is unknown. OBJECTIVES: The authors sought to study the incidence of left ventricular (LV) systolic dysfunction (LVSD), progression or regression of ≥mild-moderate AFMR, and impact on mortality. METHODS: Adults with left atrial (LA) volume index ≥40 mL/m2 , ≥mild-moderate AFMR, and follow-up echocardiogram were followed for incident LVSD (ejection fraction <50% and ≥10% lower than baseline), progression of mild-moderate/moderate AFMR to severe, and persistent regression of AFMR to no/trivial...
March 17, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38530686/lipoprotein-a-blood-levels-and-cardiovascular-risk-reduction-with-icosapent-ethyl
#2
JOURNAL ARTICLE
Michael Szarek, Deepak L Bhatt, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif, Christie M Ballantyne, R Preston Mason, Steven B Ketchum, Armando Lira Pineda, Ralph T Doyle, Ph Gabriel Steg
BACKGROUND: Elevated lipoprotein(a) (Lp[a]) concentrations are associated with increased cardiovascular event risk even in the presence of well-controlled low-density lipoprotein cholesterol levels, but few treatments are documented to reduce this residual risk. OBJECTIVES: The aim of this post hoc analysis of REDUCE-IT (Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial) was to explore the cardiovascular benefit of icosapent ethyl (IPE) across a range of Lp(a) levels...
March 15, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38530688/effect-of-sodium-glucose-cotransporter-2-inhibitors-in-adults-with-congenital-heart%C3%A2-disease
#3
JOURNAL ARTICLE
Ralph M L Neijenhuis, Simon T MacDonald, Filip Zemrak, Bart J A Mertens, Anna Dinsdale, Amanda Hunter, Niki L Walker, Lorna Swan, Sushma Reddy, Joris I Rotmans, J Wouter Jukema, Monique R M Jongbloed, Gruschen R Veldtman, Anastasia D Egorova
BACKGROUND: Heart failure (HF) is the principal cause of morbidity and mortality in adults with congenital heart disease (ACHD). Robust evidence-based treatment options are lacking. OBJECTIVES: This study aims to evaluate the safety, tolerability, and short-term HF-related effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in a real-world ACHD population. METHODS: All patients with ACHD treated with SGLT2i in 4 European ACHD centers were included in this retrospective study...
March 12, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38530685/defining-disease-progression-in%C3%A2-attr%C3%A2-cardiac-amyloidosis-keeping-it-simple
#4
EDITORIAL
Kevin M Alexander
No abstract text is available yet for this article.
March 6, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38466244/2024-acc-expert-consensus-decision-pathway-for-treatment-of-heart%C3%A2-failure-with-reduced-ejection%C3%A2-fraction-a-report-of-the-american-college-of-cardiology-solution-set-oversight-committee
#5
Thomas M Maddox, James L Januzzi, Larry A Allen, Khadijah Breathett, Sara Brouse, Javed Butler, Leslie L Davis, Gregg C Fonarow, Nasrien E Ibrahim, JoAnn Lindenfeld, Frederick A Masoudi, Shweta R Motiwala, Estefania Oliveros, Mary Norine Walsh, Alan Wasserman, Clyde W Yancy, Quentin R Youmans
No abstract text is available yet for this article.
March 2, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38530684/stratifying-disease-progression-in-patients-with-cardiac-attr-amyloidosis
#6
JOURNAL ARTICLE
Adam Ioannou, Francesco Cappelli, Michele Emdin, Christian Nitsche, Simone Longhi, Ahmad Masri, Alberto Cipriani, Mattia Zampieri, Federica Colio, Michael Poledniczek, Aldostefano Porcari, Yousuf Razvi, Alberto Aimo, Giuseppe Vergaro, Laura De Michieli, Muhammad U Rauf, Rishi K Patel, Eugenia Villanueva, Yael Lustig, Lucia Venneri, Ana Martinez-Naharro, Helen Lachmann, Ashutosh Wechalekar, Carol Whelan, Aviva Petrie, Philip N Hawkins, Scott Solomon, Julian D Gillmore, Marianna Fontana
BACKGROUND: Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive cardiomyopathy. The clinical course varies among individuals and there are no established measures to assess disease progression. OBJECTIVES: The goal of this study was to assess the prognostic importance of an increase in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and outpatient diuretic intensification (ODI) as markers of disease progression in a large cohort of patients with ATTR-CA...
March 1, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38493389/2024-acc-aha-clinical-performance-and-quality-measures-for-adults-with-valvular-and-structural-heart-disease-a-report-of-the-american-heart-association-american-college-of-cardiology-joint-committee-on-performance-measures
#7
Hani Jneid, Joanna Chikwe, Suzanne V Arnold, Robert O Bonow, Steven M Bradley, Edward P Chen, Rebecca L Diekemper, Setri Fugar, Douglas R Johnston, Dharam J Kumbhani, Roxana Mehran, Arunima Misra, Manesh R Patel, Ranya N Sweis, Molly Szerlip
No abstract text is available yet for this article.
February 29, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38471643/transcatheter-myotomy-to-reduce-left-ventricular-outflow-obstruction
#8
JOURNAL ARTICLE
Adam B Greenbaum, Hiroki A Ueyama, Patrick T Gleason, Jaffar M Khan, Christopher G Bruce, Rim N Halaby, Toby Rogers, George S Hanzel, Joe X Xie, Isida Byku, Robert A Guyton, Kendra J Grubb, John C Lisko, Nikoloz Shekiladze, Errol K Inci, Elizabeth A Grier, Gaetano Paone, James M McCabe, Robert J Lederman, Vasilis C Babaliaros
BACKGROUND: Left ventricular outflow tract (LVOT) obstruction is a source of morbidity in hypertrophic cardiomyopathy (HCM) and a life-threatening complication of transcatheter mitral (TMVR) and aortic valve replacement (TAVR). Available surgical and transcatheter approaches are limited by high surgical risk, unsuitable septal perforators, and heart block requiring permanent pacemakers. OBJECTIVES: We report the initial experience of a novel transcatheter electrosurgical procedure developed to mimic surgical myotomy...
February 16, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38385930/a-novel-cmr-ecgi-lens-exposes-the%C3%A2-electrophysiological-substrate-in%C3%A2-subclinical-hcm-a-glimmering-future-preview
#9
EDITORIAL
Babken Asatryan, Steven A Muller
No abstract text is available yet for this article.
February 13, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38385929/electrophysiological-characterization-of%C3%A2-subclinical-and-overt-hypertrophic-cardiomyopathy-by-magnetic-resonance-imaging-guided-electrocardiography
#10
JOURNAL ARTICLE
George Joy, Luis R Lopes, Matthew Webber, Alessandra M Ardissino, James Wilson, Fiona Chan, Iain Pierce, Rebecca K Hughes, Konstantinos Moschonas, Hunain Shiwani, Robert Jamieson, Paula P Velazquez, Ramya Vijayakumar, Erica Dall'Armellina, Peter W Macfarlane, Charlotte Manisty, Peter Kellman, Rhodri H Davies, Maite Tome, Vladan Koncar, Xuyuan Tao, Christoph Guger, Yoram Rudy, Alun D Hughes, Pier D Lambiase, James C Moon, Michele Orini, Gabriella Captur
BACKGROUND: Ventricular arrhythmia in hypertrophic cardiomyopathy (HCM) relates to adverse structural change and genetic status. Cardiovascular magnetic resonance (CMR)-guided electrocardiographic imaging (ECGI) noninvasively maps cardiac structural and electrophysiological (EP) properties. OBJECTIVES: The purpose of this study was to establish whether in subclinical HCM (genotype [G]+ left ventricular hypertrophy [LVH]-), ECGI detects early EP abnormality, and in overt HCM, whether the EP substrate relates to genetic status (G+/G-LVH+) and structural phenotype...
February 13, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508853/reply-aging-in-patients-with-fontan%C3%A2-circulation-raison-d-%C3%A3%C2%AAtre-of-right-ventricle
#11
LETTER
Rani Zierath, Amil M Shah
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508852/aging-in-patients-with-fontan-circulation-raison-d-%C3%A3%C2%AAtre-of-right-ventricle
#12
LETTER
Tomoaki Murakami
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508851/accuracy-of-wearable-heart-rate-monitors-during-exercise-in-sinus%C3%A2-rhythm-and-atrial%C3%A2-fibrillation
#13
LETTER
Ryan Quinn, Nathan Leader, Gerald Lebovic, Chi-Ming Chow, Paul Dorian
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508850/genetic-factors-altering-immune-responses-in-atrial-fibrillation-jacc-review-topic-of-the-week
#14
REVIEW
Sandro Ninni, David Dombrowicz, Menno de Winther, Bart Staels, David Montaigne, Stanley Nattel
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is associated with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory processes resulting from innate immune responses as a cornerstone in AF pathogenesis. Genetic and epigenetic factors affecting leukocytes have been identified as key modulators of the inflammatory response. Inherited variants in genes encoding proteins involved in the innate immune response have been associated with increased risk for AF recurrence and stroke in AF patients...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508849/frailty-and-cognitive-function-in-aging-adults-with-congenital-heart-disease-a-lifetime-of-limitations
#15
EDITORIAL
Matthew R Carazo
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508848/frailty-and-cognitive-function-in%C3%A2-middle-aged-and-older-adults-with%C3%A2-congenital-heart-disease
#16
JOURNAL ARTICLE
Bo Daelman, Liesbet Van Bulck, Koen Luyckx, Adrienne H Kovacs, Alexander Van De Bruaene, Magalie Ladouceur, Hsiao-Ling Yang, Ju Ryoung Moon, André Schmidt, Birgitte Lykkeberg, Edward Callus, Michèle de Hosson, Camilla Sandberg, Bengt Johansson, Joanna Hlebowicz, Maria Emília Areias, Pascal Amedro, Louise Coats, Zacharias Mandalenakis, Anna Kaneva, Philip Moons, Eva Goossens
BACKGROUND: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential. OBJECTIVES: The authors describe the frailty and cognitive profile of middle-aged and older adults with CHD to identify predictor variables and to explore the relationship with hospital admissions and outpatient visits...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508847/new-findings-on-ascending-aortic-dilation-in-coarctation-of-the-aorta-expanding-perspectives
#17
EDITORIAL
Daniel Rinnström, Bengt Johansson
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508846/coarctation-of-aorta-with-tricuspid-aortic-valve-is-not-associated-with-ascending%C3%A2-aortic%C3%A2-aneurysm
#18
JOURNAL ARTICLE
Alexander C Egbe, William R Miranda, Omar Abozied, C Charles Jain, Luke J Burchill, Snigdha Karnakoti, Marwan H Ahmed, Christopher J Francois, Heidi M Connolly
BACKGROUND: Aortic aneurysm is common in patients with coarctation of aorta (COA), but it is unclear whether the risk of aortic aneurysms is due to COA or related to the presence of other risk factors such as bicuspid aortic valve (BAV) and hypertension. OBJECTIVES: The purpose of this study was to assess the relationship among COA, BAV, and thoracic aortic aneurysms. METHODS: A total of 867 patients with COA (COA group) were matched 1:1:1 to 867 patients with isolated BAV (BAV group) and 867 patients without structural heart disease (SHD) (no-SHD group)...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508845/pooling-the-nt-probnp-benefits-of-arni-fret-the-index-hospitalization-no-more
#19
EDITORIAL
Bassam Atallah, Hussam H Ghalib
No abstract text is available yet for this article.
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38508844/sacubitril-valsartan-in-patients-hospitalized-with-decompensated-heart%C3%A2-failure
#20
RANDOMIZED CONTROLLED TRIAL
David A Morrow, Eric J Velazquez, Akshay S Desai, Adam D DeVore, Serge Lepage, Jeong-Gun Park, Kavita Sharma, Scott D Solomon, Randall C Starling, Jonathan H Ward, Kristin M Williamson, Shelley Zieroth, Adrian F Hernandez, Robert J Mentz, Eugene Braunwald
BACKGROUND: The efficacy and safety of sacubitril/valsartan in patients hospitalized with heart failure (HF) across the spectrum of left ventricular ejection fraction (EF) has not been described. OBJECTIVES: Data from randomized trials of sacubitril/valsartan in HF patients with EF ≤40% (PIONEER-HF [Comparison of Sacubitril/Valsartan Versus Enalapril on Effect of NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode] trial) and >40% (PARAGLIDE-HF [Prospective comparison of ARNI with ARB Given following stabiLization In DEcompensated HFpEF] trial) following recent worsening heart failure (WHF) were pooled to examine treatment effect across the EF spectrum...
March 26, 2024: Journal of the American College of Cardiology
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