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Journal of the American College of Cardiology

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https://www.readbyqxmd.com/read/29753563/critical-appraisal-of-the-2018-acc-scientific-sessions-late-breaking-trials-from-a-statistician-s-perspective
#1
REVIEW
Stuart J Pocock, Tim J Collier
The late-breaking clinical trials presentations at the American College of Cardiology Scientific Sessions in March 2018 are an important contribution to the field of cardiology. This paper presents a constructive critical appraisal of 7 key studies: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), VEST (Vest Prevention of Early Sudden Death Trial), SECURE-PCI (Statins Evaluation in Coronary Procedures and Revascularization), TREAT (Ticagrelor in Patients with ST-Elevation Myocardial Infarction treated with Pharmacological Thrombolysis), POISE (PeriOperative ISchemic Evaluation), SMART-DATE (Safety of 6-Month Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndrome), and CVD-REAL 2 (Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors)...
May 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729878/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-part-2-radiological-equipment-operation-dose-sparing-methodologies-patient-and-medical-personnel
#2
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729877/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-a-report-of-the-american-college-of-cardiology-task-force-on-expert-consensus-decision-pathways
#3
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29729876/2018-acc-hrs-nasci-scai-scct-expert-consensus-document-on-optimal-use-of-ionizing-radiation-in-cardiovascular-imaging-best-practices-for-safety-and-effectiveness-part-1-radiation-physics-and-radiation-biology
#4
John W Hirshfeld, Victor A Ferrari, Frank M Bengel, Lisa Bergersen, Charles E Chambers, Andrew J Einstein, Mark J Eisenberg, Mark A Fogel, Thomas C Gerber, David E Haines, Warren K Laskey, Marian C Limacher, Kenneth J Nichols, Daniel A Pryma, Gilbert L Raff, Geoffrey D Rubin, Donnette Smith, Arthur E Stillman, Suma A Thomas, Thomas T Tsai, Louis K Wagner, L Samuel Wann
No abstract text is available yet for this article.
April 30, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29705067/correction
#5
(no author information available yet)
No abstract text is available yet for this article.
April 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29666021/behind-the-scenes-in-the-real-world-of-heart-transplantation-will-you-accept-this-rose
#6
EDITORIAL
Larry A Allen, Prateeti Khazanie
No abstract text is available yet for this article.
March 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29666020/geographic-variation-in-the-treatment-of-u-s-adult-heart-transplant-candidates
#7
William F Parker, Allen S Anderson, Donald Hedeker, Elbert S Huang, Edward R Garrity, Mark Siegler, Matthew M Churpek
BACKGROUND: The current U.S. priority ranking for heart candidates is based on treatment intensity, not objective markers of severity of illness. This system may encourage centers to overtreat candidates. OBJECTIVES: This study sought to describe national variation in the intensity of treatment of adult heart transplantation candidates and identify center-level predictors of potential overtreatment. METHODS: The registrations of all U.S. adult heart transplantation candidates from 2010 to 2015 were collected from the SRTR (Scientific Registry of Transplant Recipients)...
March 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29567211/cardiac-toxicity-in-patients-treated-with-immune-checkpoint-inhibitors-it-is-now-time-for-cardio-immuno-oncology
#8
EDITORIAL
Carlo G Tocchetti, Maria Rosaria Galdiero, Gilda Varricchi
No abstract text is available yet for this article.
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29567210/myocarditis-in-patients-treated-with-immune-checkpoint-inhibitors
#9
Syed S Mahmood, Michael G Fradley, Justine V Cohen, Anju Nohria, Kerry L Reynolds, Lucie M Heinzerling, Ryan J Sullivan, Rongras Damrongwatanasuk, Carol L Chen, Dipti Gupta, Michael C Kirchberger, Magid Awadalla, Malek Z O Hassan, Javid J Moslehi, Sachin P Shah, Sarju Ganatra, Paaladinesh Thavendiranathan, Donald P Lawrence, John D Groarke, Tomas G Neilan
BACKGROUND: Myocarditis is an uncommon, but potentially fatal, toxicity of immune checkpoint inhibitors (ICI). Myocarditis after ICI has not been well characterized. OBJECTIVES: The authors sought to understand the presentation and clinical course of ICI-associated myocarditis. METHODS: After observation of sporadic ICI-associated myocarditis cases, the authors created a multicenter registry with 8 sites. From November 2013 to July 2017, there were 35 patients with ICI-associated myocarditis, who were compared to a random sample of 105 ICI-treated patients without myocarditis...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29540325/lower-cardiovascular-risk-associated-with-sglt-2i-in-400-000-patients-the-cvd-real-2-study
#10
Mikhail Kosiborod, Carolyn S P Lam, Shun Kohsaka, Dae Jung Kim, Avraham Karasik, Jonathan Shaw, Navdeep Tangri, Su-Yen Goh, Marcus Thuresson, Hungta Chen, Filip Surmont, Niklas Hammar, Peter Fenici
BACKGROUND: Randomized trials demonstrated lower risk of cardiovascular (CV) events with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes (T2D) at high CV risk. Prior real-world data suggested similar SGLT-2i effects in T2D patients with broader risk profile, but focused on heart failure and death, and were limited to US and Europe. OBJECTIVES: To examine a broad range of CV outcomes in patients initiated on SGLT-2i vs. other glucose lowering drugs (oGLD) across six countries in Asia Pacific, Middle East and North America (NCT02993614)...
March 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29535065/automated-atrial-fibrillation-detection-algorithm-using-smartwatch-technology
#11
Joseph M Bumgarner, Cameron T Lambert, Ayman A Hussein, Daniel J Cantillon, Bryan Baranowski, Kathy Wolski, Bruce D Lindsay, Oussama M Wazni, Khaldoun G Tarakji
BACKGROUND: The Kardia Band (KB) is a novel technology that enables patients to record a rhythm strip using an Apple smartwatch. The band is paired with an app providing automated detection of atrial fibrillation (AF). OBJECTIVES: To examine whether the KB could accurately differentiate sinus rhythm (SR) from AF compared to physician-interpreted 12-lead ECGs and KB recordings. METHODS: Consecutive patients with AF presenting for cardioversion (CV) were enrolled...
March 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29535063/cannabis-and-heart-disease-forward-into-the-great-unknown
#12
EDITORIAL
Joshua D Lee, Daniel Schatz, Judith Hochman
No abstract text is available yet for this article.
March 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29535062/cocaine-and-marijuana-use-among-young-adults-presenting-with-myocardial-infarction-the-partners-young-mi-registry
#13
Ersilia M DeFilippis, Avinainder Singh, Sanjay Divakaran, Ankur Gupta, Bradley L Collins, David Biery, Arman Qamar, Amber Fatima, Mattheus Ramsis, Daniel Pipilas, Roxanna Rajabi, Monica Eng, Jon Hainer, Josh Klein, James L Januzzi, Khurram Nasir, Marcelo F Di Carli, Deepak L Bhatt, Ron Blankstein
BACKGROUND: Substance abuse is increasingly prevalent among young adults but data on cardiovascular outcomes remain limited. OBJECTIVES: Our objective was to assess the prevalence of cocaine and marijuana use in adults with their first myocardial infarction (MI) at ≤50 years and determine its association with long-term outcomes. METHODS: We retrospectively analyzed records of patients presenting with a Type 1 MI at ≤50 years at two academic hospitals from 2000-2016...
March 5, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29544870/anti-inflammatory-therapy-with-canakinumab-for-the-prevention-and-management-of-diabetes
#14
Brendan M Everett, Marc Y Donath, Aruna D Pradhan, Tom Thuren, Prem Pais, Jose C Nicolau, Robert J Glynn, Peter Libby, Paul M Ridker
BACKGROUND: Subclinical inflammation mediated in part by interleukin-1 beta (IL-1β) participates in peripheral insulin resistance and impaired pancreatic insulin secretion. OBJECTIVES: We tested the hypothesis that canakinumab, an IL-1β inhibitor, reduces incident diabetes. METHODS: The Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS) randomized 10,061 patients with prior MI and high-sensitivity C-reactive protein (hsCRP) ≥2 mg/L to placebo or canakinumab at doses of 50mg, 150mg, or 300mg subcutaneously once every three months...
March 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29535064/short-term-global-cardiovascular-disease-risk-prediction-in-older-adults
#15
Anum Saeed, Vijay Nambi, Wensheng Sun, Salim S Virani, George Taffet, Anita Deswal, Elizabeth Selvin, Kunihiro Matsushita, Lynne E Wagenknecht, Ron Hoogeveen, Josef Coresh, James A de Lemos, Christie M Ballantyne
BACKGROUND: Current prevention guidelines recommend using the Pooled Cohort Equation (PCE) for 10-year atherosclerotic cardiovascular disease (CVD) risk assessment. However, the PCE has serious limitations in older adults: it excludes heart failure (HF) hospitalization, estimates 10-year risk which may not be the most relevant time frame, and is not indicated for individuals aged >79 years. OBJECTIVES: To determine whether adding biomarkers to PCE variables improves global CVD (coronary heart disease [CHD], stroke, and HF) risk prediction in older adults over a shorter time period...
March 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29773166/ticagrelor-and-central-sleep-apnea
#16
LETTER
Bruno Revol, Ingrid Jullian-Desayes, Renaud Tamisier, Vincent Puel, Michel Mallaret, Marie Joyeux-Faure, Jean-Louis Pépin
No abstract text is available yet for this article.
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29773165/arthur-j-moss-md-in-memoriam
#17
EDITORIAL
Eric N Prystowsky, James P Daubert
No abstract text is available yet for this article.
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29773164/helping-acc-members-deliver-higher-quality-care
#18
EDITORIAL
C Michael Valentine
No abstract text is available yet for this article.
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29773163/epicardial-adipose-tissue-may-mediate-deleterious-effects-of-obesity-and-inflammation-on-the-myocardium
#19
REVIEW
Milton Packer
Epicardial adipose tissue has unique properties that distinguish it from other depots of visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed microcirculation with the underlying myocardium, and in healthy conditions, produces cytokines that nourish the heart. However, in chronic inflammatory disorders (especially those leading to heart failure with preserved ejection fraction), the epicardium becomes a site of deranged adipogenesis, leading to the secretion of proinflammatory adipokines that can cause atrial and ventricular fibrosis...
May 22, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29773162/psychopharmacology-and-cardiovascular-disease
#20
REVIEW
Ileana L Piña, Katherine E Di Palo, Hector O Ventura
This review discusses common mental health disorders and their associations with cardiovascular disease risks. Commonly found mental health disorders include depression, anxiety, and personality types. The link between depression and cardiovascular disease mortality has been established. Depression is also common in patients with heart failure. In addition to discussing psychological disorders, a review of psychotropic drugs is also included. Drugs are described for therapy for depression and anxiety, as well as associations with cardiovascular drug-drug interactions...
May 22, 2018: Journal of the American College of Cardiology
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