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Journal of the American Academy of Dermatology

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https://www.readbyqxmd.com/read/28318681/updated-recommendations-on-the-use-of-hydroxychloroquine-in-dermatologic-practice
#1
REVIEW
Anthony P Fernandez
Hydroxychloroquine has unique immunomodulatory properties and an attractive adverse effect profile. Over the past 10 years, research has led to significant updates in clinical recommendations concerning the optimal use of hydroxychloroquine and monitoring of patients taking it. We discuss updated recommendations concerning hydroxychloroquine daily dosing, retinopathy screening, serologic monitoring, use in smokers, use in pregnant women, and adverse effect risk and monitoring. This review can hopefully serve as an aid to dermatologists and help ensure they continue using hydroxychloroquine safely and effectively...
March 16, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28318682/predicting-neurofibromatosis-type-1-risk%C3%A2-among-children-with-isolated-caf%C3%A3-au-lait%C3%A2-macules
#2
Shay Ben-Shachar, Tom Dubov, Hagit Toledano-Alhadef, Jacob Mashiah, Eli Sprecher, Shlomi Constantini, Moshe Leshno, Ludwine M Messiaen
BACKGROUND: Although isolated cafe-au-lait macules (CALMs) are a common skin finding, they are an early feature of neurofibromatosis type 1 (NF1). OBJECTIVE: We sought to develop an algorithm determining the risk of children with CALMs to have constitutional NF1. METHODS: We conducted a retrospective study of patients with isolated CALMs. Diagnosis of NF1 was based on detecting NF1 mutation in blood or fulfilling clinical criteria. RESULTS: In all, 170 of 419 (41%) and 21 of 86 (24%) children with isolated CALMs who underwent molecular testing and clinical follow-up, respectively, were given a diagnosis of NF1...
March 15, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28318680/nephrogenic-systemic-fibrosis-a-15-year-retrospective-study-at-a-single-tertiary-care-center
#3
Janice Wilson, Kristyna Gleghorn, Quincy Seigel, Brent Kelly
BACKGROUND: Despite multiple therapeutic approaches for nephrogenic systemic fibrosis (NSF), no single treatment has convincingly shown consistent benefit. The most successful outcomes have been associated with recovery of renal function, although evidence remains limited and past studies have been inconclusive. OBJECTIVE: We sought to investigate whether improvement of renal function via successful transplantation or via return of renal function after acute kidney injury correlates with improvement of NSF, and to further characterize the clinical features and progression of NSF...
March 15, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28314685/association-of-psoriasis-and-psoriatic-arthritis-with-osteoporosis-and-pathological-fractures
#4
Parul Kathuria, Kenneth B Gordon, Jonathan I Silverberg
BACKGROUND: Previous studies examining the relationship between psoriasis (Pso), osteoporosis, and pathological fractures found conflicting results. OBJECTIVE: To determine whether Pso and psoriatic arthritis (PsA) are associated with osteoporosis and fractures in US adults. METHODS: Cross-sectional study of 198,102,435 children and adults, including 183,725 with Pso and 28,765 with PsA from the 2006-2012 National Emergency Department Sample, including 20% of the emergency care visits throughout the United States...
March 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28314684/the-adverse-prognostic-effect-of-tumor-budding-on-the-evolution-of-cutaneous-head-and-neck-squamous-cell-carcinoma
#5
Miriam Gonzalez-Guerrero, Pablo Martínez-Camblor, Blanca Vivanco, Ivan Fernández-Vega, Pablo Munguía-Calzada, Maria Paz Gonzalez-Gutierrez, Juan Pablo Rodrigo, Cristina Galache, Jorge Santos-Juanes
BACKGROUND: Tumor budding is a readily detectable histopathologic feature that has been recognized as an adverse prognostic factor in several human cancers. OBJECTIVE: We sought to assess the correlation of tumor budding with the clinicopathologic features and the prognostic value of tumor budding in cutaneous squamous cell carcinoma (cSCC). METHODS: Forty-nine primary nonmetastatic and 49 primary metastatic cSCCs to regional lymph nodes were retrospectively studied...
March 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28314683/reporting-of-harm-and-safety-results-in-randomized-controlled-trials-published-in-5-dermatology-journals
#6
Cynthia Haddad, Odette Berline Sigha, Bénédicte Lebrun-Vignes, Olivier Chosidow, Laurence Fardet
BACKGROUND: Randomized controlled trials (RCTs) are considered the gold standard for assessing efficacy and short-term harm of medicines. However, several studies have come to the conclusion that harm is less well reported than efficacy outcomes. OBJECTIVE: To describe harm reporting in publications on dermatological RCTs and assess parameters that could influence the quality of harm reporting. METHODS: Methodologic systematic review of dermatologic RCTs published from 2010 to 2014 in 5 dermatological journals...
March 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28314682/hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-an-update-and-review
#7
REVIEW
Viral M Patel, Marc Z Handler, Robert A Schwartz, W Clark Lambert
Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is a rare genetic disorder that predisposes individuals to multiple cutaneous leiomyomas, renal cell carcinomas, and in women, uterine leiomyomas. Also known as Reed syndrome, it is caused by a germline heterozygous mutation of the fumarate hydratase tumor suppressor gene. HLRCC is associated with significant morbidity because of pain from cutaneous and uterine leiomyomas, the cutaneous pain often of unique character. Although genetic testing is currently considered the criterion standard to diagnose HLRCC, newer immunohistochemistry markers may provide rapid and cost effective alternatives to genetic testing...
March 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28291553/isotretinoin-treatment-for-acne-and-risk-of-depression-a-systematic-review-and-meta-analysis
#8
Yu-Chen Huang, Ying-Chih Cheng
BACKGROUND: The relationship between isotretinoin treatment for acne and depression is controversial. Quantitative analysis has not yet been conducted. OBJECTIVE: To conduct a meta-analysis, evidence-based examination of the relationship between isotretinoin and depression. METHOD: A systematic review and meta-analysis of the literature published from inception to September 30, 2016, was conducted. Controlled or prospective non-controlled trials on ≥15 acne patients receiving isotretinoin treatment were included...
March 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28291552/clinical-similarity-of-biosimilar-abp-501-to-adalimumab-in-the-treatment-of-patients-with-moderate-to-severe-plaque-psoriasis-a-randomized-double-blind-multicenter-phase-iii-study
#9
Kim Papp, Herve Bachelez, Antonio Costanzo, Peter Foley, Melinda Gooderham, Primal Kaur, Joanna Narbutt, Sandra Philipp, Lynda Spelman, Jolanta Weglowska, Nan Zhang, Bruce Strober
BACKGROUND: ABP 501 is a biosimilar of adalimumab. OBJECTIVE: We sought to compare the efficacy and safety of ABP 501 with adalimumab. METHODS: This 52-week, double-blind study randomized patients with moderate to severe psoriasis to ABP 501 or adalimumab. At week 16, those with 50% or more improvement in Psoriasis Area and Severity Index score from baseline on ABP 501 continued the same treatment, whereas adalimumab-treated patients were rerandomized to adalimumab or ABP 501...
March 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28285784/pediatric-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-the-united-states
#10
Derek Y Hsu, Joaquin Brieva, Nanette B Silverberg, Amy S Paller, Jonathan I Silverberg
BACKGROUND: Little is known about the epidemiology of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children. OBJECTIVE: We sought to determine the morbidity, mortality, and comorbid health conditions of SJS and TEN in US children. METHODS: This was a cross-sectional study of the 2009 to 2012 Nationwide Inpatient Sample, which contains a representative 20% sample of all US hospitalizations. Sociodemographics, inflation-adjusted cost, length of stay, comorbidities, and mortality were analyzed using descriptive statistics and multivariate regression analyses...
March 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28285783/histopathological-changes-in-morphea-and-their-clinical-correlates-results-from-the-morphea-in-adults-and-children-cohort-v
#11
Daniel Walker, Joseph S Susa, Sharif Currimbhoy, Heidi Jacobe
BACKGROUND: Histopathological features in morphea (localized scleroderma) and their clinical correlates are poorly described. OBJECTIVE: We sought to systematically describe histologic changes of morphea in a large, well-annotated cohort and determine the association between histopathology and clinical features. METHODS: This was a cross-sectional study of 83 patients enrolled in the Morphea in Adults and Children cohort. The main outcome measure was the association of microanatomical location and degree of sclerosis and inflammation seen on histologic samples with patient-reported symptoms and physician-based measures of severity...
March 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28285782/incidence-of-hidradenitis-suppurativa-in-the-united-states-a-sex-and-age-adjusted-population-analysis
#12
Amit Garg, Jonathan Lavian, Gloria Lin, Andrew Strunk, Allireza Alloo
BACKGROUND: The true incidence of hidradenitis suppurativa (HS) is unknown. OBJECTIVE: To determine standardized incidence estimates for HS in the United States. METHODS: We used a retrospective cohort analysis, including incident HS cases identified using electronic health records data for a demographically heterogeneous population-based sample of >48 million unique patients across all 4 census regions. We calculated standardized 1- and 10-year cumulative incidences for the overall population and for sex-, age-, and race-specific groups...
March 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28285781/calciphylaxis-comparison-of-radiologic-imaging-and-histopathology
#13
Charles L Halasz, David P Munger, Heather Frimmer, Michael Dicorato, Sandra Wainwright
BACKGROUND: The current gold standard for diagnosis of calciphylaxis is a skin biopsy specimen demonstrating calcification of small-caliber arteries or arterioles. OBJECTIVE: The aim of this study is to compare diameters of calcified vessels seen in skin biopsy specimens and radiology images of patients with calciphylaxis. METHODS: We conducted a retrospective study of patients with known calciphylaxis from 2009 to 2016 at a community hospital who had both skin biopsy specimens and radiology images taken as part of their routine care...
March 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28284826/permanent-alopecia-in-patients-with-breast-cancer-after-taxane-chemotherapy-and-adjuvant-hormonal-therapy-clinicopathologic-findings-in-a-cohort-of-10-patients
#14
Athina Fonia, Carlo Cota, Jane F Setterfield, Lynne J Goldberg, David A Fenton, Catherine M Stefanato
BACKGROUND: Anagen effluvium with reversible scalp alopecia is a known side effect of chemotherapy. However, there are an increasing number of reports in the literature documenting permanent alopecia in patients treated with taxanes. OBJECTIVE: We sought to describe the clinicopathologic features in breast cancer patients who underwent treatment with taxanes and adjuvant hormonal chemotherapy. METHODS: We reviewed the clinical and histopathologic information of a cohort of 10 patients treated with taxanes and adjuvant hormonal chemotherapy...
March 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28259440/suction-blistering-the-lesional-skin-of-vitiligo-patients-reveals-useful-biomarkers-of-disease-activity
#15
James P Strassner, Mehdi Rashighi, Maggi Ahmed Refat, Jillian M Richmond, John E Harris
BACKGROUND: Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies. OBJECTIVE: To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and healthy subjects. METHODS: Patient skin was sampled via a modified suction-blister technique, allowing for minimally invasive, objective assessment of cytokines and T-cell infiltrates in the interstitial skin fluid...
March 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28259441/the-burden-of-skin-disease-in-the-united-states
#16
Henry W Lim, Scott A B Collins, Jack S Resneck, Jean L Bolognia, Julie A Hodge, Thomas A Rohrer, Marta J Van Beek, David J Margolis, Arthur J Sober, Martin A Weinstock, David R Nerenz, Wendy Smith Begolka, Jose V Moyano
Since the publication of the last US national burden of skin disease report in 2006, there have been substantial changes in the practice of dermatology and the US health care system. These include the development of new treatment modalities, marked increases in the cost of medications, increasingly complex payer rules and regulations, and an aging of the US population. Recognizing the need for up-to-date data to inform researchers, policy makers, public stakeholders, and health care providers about the impact of skin disease on patients and US society, the American Academy of Dermatology produced a new national burden of skin disease report...
February 27, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28259439/burden-of-skin-disease-report-implications-for-dermatology
#17
EDITORIAL
Karen Edison, Bruce Brod
No abstract text is available yet for this article.
February 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28245942/clinical-markers-of-vitiligo-activity
#18
Laila Benzekri, Yvon Gauthier
BACKGROUND: Current modalities of understanding disease state (active/stable) are limited when considering treatment of vitiligo. OBJECTIVE: We sought to develop a rapid, accurate, and noninvasive assessment of vitiligo state. METHODS: In daylight and Wood's light examinations, 2 common clinical types of vitiligo were identified as amelanotic with sharply demarcated borders and hypomelanotic with poorly defined borders. Photographs were taken at the time of examination and a skin biopsy at the edge of a vitiligo lesion was performed...
February 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28242090/congenital-melanocytic-nevi-in-young-children-histopathologic-features-and-clinical-outcomes
#19
Emily A Simons, Jennifer T Huang, Birgitta Schmidt
BACKGROUND: Although only large congenital melanocytic nevi (CMN) are associated with a significantly high risk for malignant transformation, CMN of all sizes are prone to changes in clinical appearance in early childhood and thus are often biopsied or excised. While CMNs typically exhibit benign behavior, atypical histopathologic findings might be common and may prompt additional unnecessary procedures. OBJECTIVE: To assess the prevalence and associated clinical outcomes of atypical histopathologic features in CMN in children...
February 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28238453/vitiligo-and-overt-thyroid-diseases-a-nationwide-population-based-study-in-korea
#20
Jung Min Bae, June Hyunkyung Lee, Jae Seung Yun, Byeol Han, Tae Young Han
BACKGROUND: Associations between vitiligo and thyroid diseases have been reported repeatedly. OBJECTIVE: We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database. METHODS: We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. We also established an age- and sex-matched control group without vitiligo (2 per 1 vitiligo patient)...
February 23, 2017: Journal of the American Academy of Dermatology
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