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Journal of the American Academy of Dermatology

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https://www.readbyqxmd.com/read/28927663/developing-biomarkers-for-predicting-clinical-relapse-in-pemphigus-patients-treated-with-rituximab
#1
Lauren N Albers, Yuan Liu, Na Bo, Robert A Swerlick, Ron J Feldman
BACKGROUND: Rituximab is an effective therapy for pemphigus, although relapses are common. OBJECTIVE: To identify biomarkers to predict relapse of pemphigus following rituximab treatment. METHODS: In this retrospective cohort study, 62 patients with pemphigus treated with 99 rituximab cycles provided longitudinal clinical scoring and biomarker data, including levels of CD19(+) B cells, CD4(+) T cells, and desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) autoantibodies...
September 16, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28918974/pigmentary-changes-in-patients-treated-with-targeted-anticancer-agents-a-systematic-review-and-meta-analysis
#2
Julia Dai, Viswanath R Belum, Shenhong Wu, Vincent Sibaud, Mario E Lacouture
BACKGROUND: The discovery of signaling networks that drive oncogenic processes has led to the development of targeted anticancer agents. The burden of pigmentary adverse events from these drugs is unknown. OBJECTIVE: To conduct a systematic review and meta-analysis of published clinical trials and determine the incidence and risk of development of targeted therapy-induced pigmentary changes. METHODS: A comprehensive search was conducted to identify studies reporting targeted therapy-induced pigmentary changes...
September 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28918973/atypical-features-and-systemic-associations-in-extensive-cases-of-grover-disease-a-systematic-review
#3
REVIEW
Madeleine Gantz, Daniel Butler, Matthew Goldberg, Jubin Ryu, Timothy McCalmont, Kanade Shinkai
BACKGROUND: Grover disease is an acantholytic disorder that typically occurs on the trunk of older individuals, primarily white men, in association with heat and xerosis. Cases with extensive and/or atypical distributions have been reported. OBJECTIVE: To review the literature characterizing the population, morphology, associations, and disease course of extensive or atypical eruptions of Grover disease. METHODS: A systematic literature review identified 50 articles with 69 cases...
September 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917384/serious-infections-among-a-large-cohort-of-subjects-with-systemically-treated-psoriasis
#4
Allison S Dobry, Charles P Quesenberry, G Thomas Ray, Jamie L Geier, Maryam M Asgari
BACKGROUND: Biologic therapy is effective for treatment of moderate-to-severe psoriasis but may be associated with an increased risk for serious infection. OBJECTIVE: To estimate the serious infection rate among patients with psoriasis treated with biologic as compared with nonbiologic systemic agents within a community-based health care delivery setting. METHODS: We identified 5889 adult Kaiser Permanente Northern California health plan members with psoriasis who had ever been treated with systemic therapies and calculated the incidence rates and 95% confidence intervals (CIs) for serious infections over 29,717 person-years of follow-up...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917383/efficacy-and-safety-of-ixekizumab-for-the-treatment-of-moderate-to-severe-plaque-psoriasis-results-through-108%C3%A2-weeks-of-a-randomized-controlled-phase-3-clinical-trial-uncover-3
#5
Andrew Blauvelt, Melinda Gooderham, Lars Iversen, Susan Ball, Lu Zhang, Noah O Agada, Kristian Reich
BACKGROUND: Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin 17A, is efficacious in treating moderate-to-severe plaque psoriasis through 60 weeks. OBJECTIVE: To evaluate the efficacy and safety of ixekizumab through 108 weeks of treatment in UNCOVER-3. METHODS: Patients (N = 1346) were randomized 2:2:2:1 to 80 mg ixekizumab every 2 or 4 weeks, 50 mg etanercept twice weekly, or placebo. At week 12, patients switched to ixekizumab every 4 weeks during a long-term extension (LTE) period...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917382/a-new-evidence-based-risk-stratification-system-for-cutaneous-squamous-cell-carcinoma-into-low-intermediate-and-high-risk-groups-with-implications-for-management
#6
REVIEW
Christian L Baum, Adam C Wright, Juan-Carlos Martinez, Christopher J Arpey, Jerry D Brewer, Randall K Roenigk, Clark C Otley
Most primary cutaneous squamous cell carcinomas are cured with surgery. A subset, however, may develop local and nodal metastasis that may eventuate in disease-specific; death. This subset has been variably termed high risk. Herein, we review; an emerging body of data on the risks of these outcomes and propose an evidence-based; risk stratification for low-, intermediate-, and high-risk tumors that takes into; account both tumor and patient characteristics. Finally, we discuss a framework for; management of these tumors on the basis of data, when available, and our; recommendations when data are sparse...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917381/uncovering-burden-disparity-a-comparative-analysis-of-the-impact-of-moderate-to-severe-psoriasis-and-hidradenitis-suppurativa
#7
Iltefat H Hamzavi, Murali Sundaram, Cynthia Nicholson, Marko Zivkovic, Angela Parks-Miller, Jianyi Lee, Jingbo Yi, Yihua Gu, Martin M Okun, Arijit Ganguli, Steve R Arikian
BACKGROUND: Psoriasis and hidradenitis suppurativa (HS) exhibit distinct clinical features, but no studies have directly compared the health-related quality of life (HRQoL) in patients with moderate-to-severe manifestations of these conditions. OBJECTIVE: To determine which disease is associated with more severe HRQoL impairment. METHODS: Weighted averages of each of the following baseline HRQoL measures were determined and compared between HS and psoriasis populations from 5 clinical trials: Visual Analog Scale (VAS) for pain, Total Work Productivity Impairment, Dermatology Life Quality Index; EuroQOL 5D VAS, and Short Form-36 Health Survey...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28893407/risk-of-malignancy-with-systemic-psoriasis-treatment-in-the-psoriasis-longitudinal-assessment-registry
#8
David Fiorentino, Vincent Ho, Mark G Lebwohl, Luiz Leite, Lori Hopkins, Claudia Galindo, Kavitha Goyal, Wayne Langholff, Steven Fakharzadeh, Bhaskar Srivastava, Richard G Langley
BACKGROUND: The effect of systemic therapy on malignancy risk among patients with psoriasis is not fully understood. OBJECTIVE: Evaluate the impact of systemic treatment on malignancy risk among patients with psoriasis in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METHODS: Nested case-control analyses were performed among patients with no history of malignancy. Cases were defined as first malignancy (other than nonmelanoma skin cancer) in the Psoriasis Longitudinal Assessment and Registry, and controls were matched by age, sex, geographic region, and time on registry...
September 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28865865/managing-sharps-injuries-and-other-occupational-exposures-to-hiv-hbv-and-hcv-in-the-dermatology-office
#9
REVIEW
Jerry D Brewer, Dirk M Elston, Allison T Vidimos, Stacey A Rizza, Stanley J Miller
Dermatologists and their staff are at risk for needlestick injuries and exposures to body fluids. Despite the availability of treatment to reduce the risk of blood-borne infection, many exposures go unreported. This paper identifies current recommendations and the specific details for response to occupational exposures to HIV, hepatitis B virus, and hepatitis C virus in the dermatology office. Issues surrounding each virus are discussed individually, and a summary step-by-step algorithm of how to proceed in the event of an occupational exposure is presented...
August 30, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28865864/clinicopathologic-and-immunophenotypic-features-of-eosinophilic-fasciitis-and-morphea-profunda-a-comparative-study-of-27-cases
#10
Oluwakemi Onajin, Carilyn N Wieland, Margot S Peters, Christine M Lohse, Julia S Lehman
BACKGROUND: Eosinophilic fasciitis (EF) and morphea profunda (MP) are inflammatory and sclerosing disorders of the subcutis that can exhibit clinical and pathologic presentations that overlap. OBJECTIVE: To identify clinicopathologic features that can be used to distinguish EF from MP. METHODS: We performed a retrospective review of 16 patients with EF and 11 patients with MP. Hematoxylin-eosin, CD123, CD34, and Verhoeff-Van Gieson stains were evaluated on skin biopsies that included the fascia...
August 30, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28864306/a-meta-analysis-of-nevus-associated-melanoma-prevalence-and-practical-implications
#11
REVIEW
Riccardo Pampena, Athanassios Kyrgidis, Aimilios Lallas, Elvira Moscarella, Giuseppe Argenziano, Caterina Longo
The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case-control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0...
August 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28864307/identifying-gaps-in-consumer-knowledge-about-sunscreen
#12
Lucy X Chao, Sarah L Sheu, Betty Y Kong, Alfred W Rademaker, Roopal V Kundu
No abstract text is available yet for this article.
August 18, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28826926/correction
#13
(no author information available yet)
No abstract text is available yet for this article.
August 18, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28822558/wilms-tumor-screening-in-diffuse-capillary-malformation-with-overgrowth-and-macrocephaly-capillary-malformation-a-retrospective-study
#14
Caitlin M Peterman, Sophie Vadeboncoeur, John B Mulliken, Steven J Fishman, Marilyn G Liang
BACKGROUND: CLOVES (congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal anomalies) syndrome is associated with regional bony and/or soft tissue overgrowth, capillary malformation, and an increased risk for Wilms tumor. OBJECTIVE: To evaluate the frequency of Wilms tumor in patients with 2 similar conditions: diffuse capillary malformation with overgrowth (DCMO) and macrocephaly-capillary malformation (M-CM). METHODS: Culling our Vascular Anomalies Center database, we retrospectively reviewed patients in whom DCMO and M-CM had been diagnosed and who were evaluated between 1998 and 2016 for possible development of Wilms tumor...
August 16, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28818438/cancer-risks-and-survival-in-patients-with-multiple-primary-melanomas-association-with-family-history-of-melanoma-and-germline-cdkn2a-mutation-status
#15
Hildur Helgadottir, Rainer Tuominen, Håkan Olsson, Johan Hansson, Veronica Höiom
BACKGROUND: Worse outcomes have been noted in patients with multiple primary melanomas (MPMs) than in patients with single primary melanomas. OBJECTIVE: We investigated how family history of melanoma and germline CDKN2A mutation status of MPM patients affects risks of developing subsequent melanomas and other cancers and survival outcomes. METHODS: Comprehensive data on cancer diagnoses and deaths of MPM patients, their first-degree relatives, and matched controls were obtained through Swedish national health care and population registries...
August 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28818436/use-of-the-hemangioma-severity-scale-to-facilitate-treatment-decisions-for-infantile-hemangiomas
#16
Andre Vadimovich Moyakine, Bjorn Herwegen, Catharina Joanna Maria van der Vleuten
BACKGROUND: The Hemangioma Severity Scale (HSS) assesses the severity of an infantile hemangioma (IH). OBJECTIVE: First, to compare HSS scores between patients with IH for whom propranolol treatment was indicated at their first visit and those who were not treated. Second, to assess suitable cutoff values for the need for propranolol treatment. METHOD: All patients with IH who attended our tertiary referral center since 2008 and were 0 to 6 months of age at their first visit were included...
August 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28754310/a-single-institution-assessment-of%C3%A2-superficial-spreading-melanoma-ssm-in-the-pediatric-population-molecular-and-histopathologic-features-compared-with-adult-ssm
#17
Anna Elisa Verzì, Jeffrey A Bubley, Alexandra M Haugh, Bin Zhang, Annette Wagner, Lacey Kruse, Dennis P West, Jeffrey Wayne, Joan Guitart, Pedram Gerami
BACKGROUND: The epidemiology of pediatric melanoma is distinct from that seen in adults. This is more distinguishable when pediatric patients are separated into prepubertal and adolescent groups. OBJECTIVE: In this study, we compared epidemiologic, clinical, histologic, and molecular characteristics of pediatric superficial spreading melanoma (SSM) in prepubertal and adolescent patients to that in adults. METHOD: We reviewed our database for pediatric melanomas, comparing SSM data between pediatric and adult cases for pathologic stage at presentation, ratio of radial to vertical growth phase, average Breslow depth and mitotic index, and frequency of fluorescence in situ hybridization (FISH) positivity...
July 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728872/oropharyngeal-lesions-in-pityriasis-rosea
#18
Giulia Ciccarese, Francesco Broccolo, Alfredo Rebora, Aurora Parodi, Francesco Drago
BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. OBJECTIVE: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728870/outpatient-dermatology-consultation-impacts-the-diagnosis-and-management-of-pediatric-oncology-patients-a-retrospective-study
#19
Hannah Song, Sarah N Robinson, Jennifer T Huang
BACKGROUND: The impact of dermatology consultation on the care of children with oncologic conditions is unknown. OBJECTIVE: To review outpatient dermatology visits and the resulting impact on diagnosis and management of pediatric oncology patients. METHOD: Retrospective review of pediatric oncology patients with outpatient dermatology visits at a tertiary care center from 2008 to 2015. RESULTS: The most common dermatologic diagnoses in 516 patients were skin infections (21...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728869/aesthetic-outcome-and-complications-of-simple-interrupted-versus-running-subcuticular-sutures-in-facial-surgery-a-randomized-controlled-trial
#20
Xiaomeng Liu, Patty J Nelemans, Lisa D S Frenk, Helma Sengers, Stephania M H Tuinder, Peter M Steijlen, Klara Mosterd, Nicole W J Kelleners-Smeets
BACKGROUND: The suturing technique and its associated complications could affect cosmetic outcome after facial surgery. Literature on this topic is limited. OBJECTIVE: To compare the cosmetic results 12 months after treatment and complications associated with simple interrupted sutures (SIS) versus running subcuticular sutures (RSS) in facial surgery. METHODS: A randomized, controlled multicenter trial was performed. Adults receiving dermatologic surgery on the face were randomized to receive SIS or RSS for wound closure...
July 17, 2017: Journal of the American Academy of Dermatology
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