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Journal of the American Academy of Dermatology

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https://www.readbyqxmd.com/read/28645647/racial-disparity-in-mycosis-fungoides-an-analysis-of-4495-cases-from-the-us-national-cancer-database
#1
Chang Su, Kevin A Nguyen, Harrison X Bai, Ya Cao, Yongguang Tao, Rong Xiao, Giorgos Karakousis, Paul J Zhang, Guiying Zhang
BACKGROUND: Studies have shown contradictory results regarding the survival outcomes among white, African American, and Asian patients with mycosis fungoides (MF). OBJECTIVE: To evaluate the survival outcomes among white, African American, and Asian patients with MF and to determine other prognostic factors of the disease. METHODS: The US National Cancer Database was used to identify patients with histologically confirmed MF from 2004 to 2014...
June 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28645646/association-of-bullous-pemphigoid-with-malignancy-a-systematic-review-and-meta-analysis
#2
Lihi Atzmony, Ilit Mimouni, Ofer Reiter, Yael Anne Leshem, Omar Taha, Michael Gdalevich, Emmilia Hodak, Daniel Mimouni
BACKGROUND: Studies evaluating whether malignancy rate is increased in patients with bullous pemphigoid (BP) have reached conflicting results. OBJECTIVE: We sought to determine whether BP is associated with malignancy. METHOD: Medline, EMBASE, the Cochrane library, and reference lists of included studies were searched for comparative studies that evaluated the relationship between BP and malignancy. Data were analyzed on the basis of study design: cross-sectional, case control, and cohort...
June 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28624120/histologic-features-of-chronic-cutaneous-lupus-erythematosus-of-the-scalp-using-horizontal-sectioning-emphasis-on-follicular-findings
#3
Hye Jin Chung, Lynne J Goldberg
BACKGROUND: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition. OBJECTIVE: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. METHODS: We conducted a retrospective study of 33 transversely sectioned skin biopsy specimens of CCLE of the scalp at the Skin Pathology Laboratory at Boston University between April 2005 and March 2015...
June 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28624119/skin-infiltrating-interleukin-22-producing-t-cells-differentiate-pediatric-psoriasis-from-adult-psoriasis
#4
Kelly M Cordoro, Maria Hitraya-Low, Keyon Taravati, Priscila Munoz Sandoval, Esther Kim, Jeffrey Sugarman, Mariela L Pauli, Wilson Liao, Michael D Rosenblum
BACKGROUND: Evidence from adult psoriasis studies implicates an imbalance between regulatory and effector T cells, particularly TH-17-producing T cells, in the pathogenesis of psoriasis. Little is known about the immunopathology of psoriasis in children. OBJECTIVE: We sought to functionally characterize the inflammatory cell profiles of psoriatic plaques from pediatric patients and compare them with healthy, age-matched controls and adult psoriasis patients. METHODS: Skin samples from pediatric psoriasis patients and healthy controls were analyzed by multiparameter flow cytometry to determine the dominant immune cell subsets present and cytokines produced...
June 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28623046/real-world-burden-of-comorbidities-in-us-patients-with-psoriasis
#5
Kamal Shah, Lillian Mellars, Arun Changolkar, Steven R Feldman
BACKGROUND: Understanding background comorbidity rates in psoriasis can provide perspective for adverse events associated with new therapies. OBJECTIVE: We sought to assess the extent of comorbidities in psoriasis patients by use of the Truven Health Analytics MarketScan database. METHODS: MarketScan, comprising commercial claims representative of a large US-insured population, had 1.22 million patients with ≥1 claim with a psoriasis diagnosis between January 1, 2008, and December 31, 2014...
June 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28623045/the-risk-of-malignancy-among-biologic-na%C3%A3-ve-pediatric-psoriasis-patients-a-retrospective-cohort-study-in-a-us-claims-database
#6
Yun Gu, Beth L Nordstrom
BACKGROUND: Little published literature exists regarding malignancy risk in pediatric psoriasis patients. OBJECTIVE: To compare malignancy risk in biologic-naïve pediatric psoriasis patients with a matched pediatric population without psoriasis. METHODS: This retrospective cohort study used IMS LifeLink Health Plan Claims data covering 1998-2008. Cancer incidence was compared with the US Surveillance, Epidemiology, and End Results (SEER) data using standardized incidence ratios (SIR), and between cohorts using Cox models...
June 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28606712/development-of-classification-criteria-for-discoid-lupus-erythematosus-results-of-a-delphi-exercise
#7
Scott A Elman, Cara Joyce, Filippa Nyberg, Fukumi Furukawa, Mark Goodfield, Minoru Hasegawa, Branka Marinovic, Jacek C Szepietowski, Jan Dutz, Victoria P Werth, Joseph F Merola
BACKGROUND: No classification criteria currently exist for discoid lupus erythematosus (DLE), which has led to problematic heterogeneity in both observational and interventional research efforts. OBJECTIVES: We sought to develop DLE classification criteria based on consensus of international expert opinion of relevant stakeholders in the field. METHODS: Using a Delphi consensus process and nominal group techniques, potential items for classification criteria were generated...
June 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28606711/impact-of-atopic-dermatitis-on-health-related-quality-of-life-and-productivity-in-adults-in-the-united-states-an-analysis-using-the-national-health-and-wellness-survey
#8
Laurent Eckert, Shaloo Gupta, Caroline Amand, Abhijit Gadkari, Puneet Mahajan, Joel M Gelfand
BACKGROUND: Given its public health impact, there is need for broad and representative data on the humanistic burden of atopic dermatitis (AD). OBJECTIVE: To establish the humanistic burden of AD in US adults. METHODS: Data were from the 2013 US National Health and Wellness Survey; AD self-reports were propensity-matched with non-AD controls and with psoriasis controls. Bivariate analyses were conducted on burden outcomes between the AD and control groups...
June 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28601392/histopathologic-features-of-melanoma-in-difficult-to-diagnose-lesions-a-case-control-study
#9
Manuel Lora Gonzalez, Eric D Young, James Bush, Katelyn McKenzie, Edgar Hunt, Viseslav Tonkovic-Capin, Melissa Jacobs, Michael Kucenic, Garth R Fraga
BACKGROUND: Dermatopathology is considered the gold standard for melanoma diagnosis, but a subset of cases is difficult to diagnose by histopathology. OBJECTIVE: The goals of this study were to measure the accuracy of histopathologic features in difficult-to-diagnose melanocytic tumors and the interobserver agreement of those features. METHODS: This is a case-control study of histopathologic features of melanoma in 100 difficult-to-diagnose melanocytic neoplasms (40 melanomas and 60 nevi)...
June 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28601391/incidence-prevalence-and-risk-of-selected-ocular-disease-in-adults-with-atopic-dermatitis
#10
Jacob P Thyssen, Peter B Toft, Anne-Sofie Halling-Overgaard, Gunnar H Gislason, Lone Skov, Alexander Egeberg
BACKGROUND: Ocular comorbidities are common in atopic dermatitis (AD) as the result of the disease itself or the use of medication. No large-scale epidemiologic data exist on the prevalence of ocular comorbidities in adults with AD. OBJECTIVES: We sought to examine the prevalence and risk of selected ocular comorbidities in adult patients with AD. METHODS: All Danish individuals ≥18 years of age were linked in nationwide registries. Adjusted hazard ratios (HRs) were estimated by means of Cox regression...
June 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28601390/frequency-of-and-risk-factors-for-tumor-upstaging-after-wide-local-excision-of-primary-cutaneous-melanoma
#11
Jeremy R Etzkorn, John M Sharkey, John W Grunyk, Thuzar M Shin, Joseph F Sobanko, Christopher J Miller
BACKGROUND: Detecting a more advanced stage of the primary melanoma after wide local excision and reconstruction can complicate patient counseling about prognosis, management of surgical margins, and indications for sentinel lymph node biopsy. OBJECTIVE: To identify the frequency of and risk factors associated with upstaging after wide local excision of primary melanoma. METHODS: Retrospective, single center, cross-sectional study of 1332 consecutive in situ to stage T4a melanomas treated with wide local excision...
June 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28578999/utility-and-tolerability-of-the-long-pulsed-1064-nm-neodymium-yttrium-aluminum-garnet-lp-nd-yag-laser-for-treatment-of-symptomatic-or-disfiguring-vascular-malformations-in-children-and-adolescents
#12
Aditi S Murthy, Annelise Dawson, Deepti Gupta, Shanna Spring, Kelly M Cordoro
BACKGROUND: Vascular malformations manifest with pain, bleeding, disability, and disfigurement in a subset of children. There are scant data available on the utility and tolerability of laser surgery for symptomatic or disfiguring non-port-wine stain vascular malformations in children. OBJECTIVE: The objective of this study was to determine the utility and tolerability of the 1064-nm long-pulsed neodymium:yttrium-aluminum-garnet (LP Nd:YAG) laser for treatment of symptomatic or disfiguring vascular malformations in children...
June 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28552300/correction
#13
(no author information available yet)
No abstract text is available yet for this article.
May 25, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28551069/gene-expression-of-sphingolipid-metabolism-pathways-is-altered-in-hidradenitis-suppurativa
#14
Mohammed Dany, Dirk Elston
BACKGROUND: Hidradenitis suppurativa (HS) is a debilitating skin disease characterized by painful recurrent nodules and abscesses caused by chronic inflammation. Early events in the development of HS are believed to occur in the folliculopilosebaceous unit; however, the signaling pathways behind this mechanism are unknown. Sphingolipids, such as ceramide, are essential components of the skin and appendages and have important structural and signaling roles. OBJECTIVE: We sought to explore whether the gene expression of enzymes involved in sphingolipid metabolic pathways is altered in HS...
May 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28551068/therapeutic-targets-in-the-management-of-striae-distensae-a-systematic-review
#15
REVIEW
Adam Hague, Ardeshir Bayat
BACKGROUND: Striae distensae are permanent dermal lesions that can cause significant psychosocial distress. A detailed understanding of the numerous treatment modalities available is essential to ensuring optimal patient outcomes. OBJECTIVE: Our objective was to evaluate and summarize the different treatment methods for striae distensae by linking their proposed modes of action with the histopathogenesis of the condition to guide patient treatment. METHODS: A systematic review of the literature was performed with no limits placed on publication date...
May 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28502377/long-term-follow-up-of-patients-undergoing-autologous-noncultured-melanocyte-keratinocyte-transplantation-for-vitiligo-and-other-leukodermas
#16
Narumol Silpa-Archa, James L Griffith, Richard H Huggins, Marsha D Henderson, Holly A Kerr, Gordon Jacobsen, Sanjeev V Mulekar, Henry W Lim, Iltefat H Hamzavi
BACKGROUND: Persistence of pigmentation after a melanocyte-keratinocyte transplantation procedure (MKTP) is an important consideration for efficacy. OBJECTIVE: We sought to determine long-term repigmentation of MKTP in vitiligo and other leukodermas. METHODS: A retrospective review of electronic medical records was conducted for all MKTPs performed at Henry Ford Hospital between January 2009 and April 2014. Repigmentation was assessed by a 5-point grading scale (poor to excellent) and Vitiligo Area Scoring Index (VASI)...
May 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28502378/long-term-treatment-of-cutaneous-manifestations-of-tuberous-sclerosis-complex-with-topical-1-sirolimus-cream-a-prospective-study-of-25-patients
#17
Nausicaa Malissen, Laurence Vergely, Marguerite Simon, Agathe Roubertie, Marie-Claire Malinge, Didier Bessis
BACKGROUND: Data on long-term topical sirolimus treatment of the cutaneous manifestations of tuberous sclerosis complex are rare. OBJECTIVE: To evaluate the long-term benefit and tolerance of topical 1% sirolimus in tuberous sclerosis complex. METHODS: In this 18-month prospective single-center study, 1% sirolimus cream was applied daily to facial angiofibromas (FAs), fibrous cephalic plaques (FCPs), shagreen patches, hypomelanotic macules, and ungual fibromas...
May 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28499754/methotrexate-induced-epidermal-necrosis-a-case-series-of-24-patients
#18
Ting-Jui Chen, Wen-Hung Chung, Chun-Bing Chen, Rosaline Chung-Yee Hui, Yu-Huei Huang, Yueh-Tsung Lu, Chang-Wei Wang, Kuo-Hsien Wang, Li-Cheng Yang, Shuen-Iu Hung
BACKGROUND: Methotrexate-induced epidermal necrosis (MEN) is a rare but life-threatening cutaneous reaction that mimics Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). OBJECTIVES: To investigate the clinicopathology, risk factors, and prognostic factors of MEN. METHODS: We enrolled 24 patients with MEN and 150 controls and analyzed the demographics, pathology, and plasma concentrations of methotrexate (MTX). RESULTS: Patients with MEN showed extensive skin necrosis (mean, 33...
May 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28495496/aggressive-digital-papillary-adenocarcinoma-a-clinicopathological-study-of-19-cases
#19
Noëlle Weingertner, Anne Gressel, Maxime Battistella, Bernard Cribier
BACKGROUND: Aggressive digital papillary adenocarcinomas (ADPA) are malignant tumors of sweat glands having recurrence/metastatic potential. OBJECTIVE: We sought to describe the clinical/histopathological characteristics of a series of ADPA. METHODS: This is a retrospective case series of 19 ADPA. RESULTS: The tumors occurred in 17 men and 2 women (mean age: 47 years). They involved digits (15), big toe (3), and palm (1), and measured from 3 to 30 mm...
May 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28495498/venous-thromboembolism-in-patients-with-pemphigus-a-cohort-study
#20
Yael Anne Leshem, Lihi Atzmony, Israel Dudkiewicz, Emmilia Hodak, Daniel Mimouni
BACKGROUND: Venous thromboembolism (VTE) has been reported to be a significant cause of death in patients with pemphigus. OBJECTIVE: We sought to assess the incidence and characteristics of VTE in patients with pemphigus. METHODS: A retrospective study following a cohort of 172 patients with newly diagnosed pemphigus for the development of VTE was conducted. RESULTS: Over a mean follow-up time of 4 years, 10 patients (6%) had development of VTE at a median of 4 months from pemphigus diagnosis...
May 8, 2017: Journal of the American Academy of Dermatology
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