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Journal of the American Academy of Dermatology

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https://www.readbyqxmd.com/read/28427793/contribution-of-health-care-factors-to-the-burden-of-skin-disease-in-the-united-states
#1
Henry W Lim, Scott A B Collins, Jack S Resneck, Jean L Bolognia, Julie A Hodge, Thomas A Rohrer, Marta J Van Beek, David J Margolis, Arthur J Sober, Martin A Weinstock, David R Nerenz, Wendy Smith Begolka, Jose V Moyano
The American Academy of Dermatology has developed an up-to-date national Burden of Skin Disease Report on the impact of skin disease on patients and on the US population. In this second of 3 manuscripts, data are presented on specific health care dimensions that contribute to the overall burden of skin disease. Through the use of data derived from medical claims in 2013 for 24 skin disease categories, these results indicate that skin disease health care is delivered most frequently to the aging US population, who are afflicted with more skin diseases than other age groups...
April 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28420485/subcutaneous-dermatofibrosarcoma-protuberans-a-rare-subtype-with-predilection-for-the-head-a-retrospective-series-of-18-cases
#2
Beatriz Llombart, Carlos Serra-Guillén, Luis Rubio, Eduardo Nagore, Celia Requena, Victor Traves, Laura Calomarde, Bernardo Bancalari, José Antonio López-Guerrero, Carlos Guillen-Barona, Onofre Sanmartín
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) typically affects the dermis and subcutaneous tissue. The subcutaneous variant is rare. OBJECTIVE: We sought to characterize the subcutaneous DFSP (SC-DFSP) variant and compare it with cutaneous DFSP (C-DFSP). METHODS: This work was a retrospective study of DFSP treated in our institution. RESULTS: Of 124 cases of DFSP, 18 were SC-DFSP (14.5%). Except for the deep location, the pathologic and genetic features were indistinguishable from the C-DFSP variant...
April 15, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28416344/25-hydroxyvitamin-d3-serum-modulation-after-use-of-sunbeds-compliant-with-european-union-standards-a-randomized-open-observational-controlled-trial
#3
Benedikt Weber, Chantal C Bachmann, Ralph Braun, Alison G Abraham, Andreas L Serra, Günther F L Hofbauer
BACKGROUND: Regular use of sunbed exposure has been reported to increase 25-hydroxyvitamin-D3 [25(OH)D] serum levels. However, the influence of sunbeds compliant with the recent European Union standard EN-60335-2-27 on 25(OH)D serum levels is unknown. OBJECTIVE: We investigated the impact of standard sunbed use compliant with the European Union standard on 25(OH)D serum modulation and well-being. METHODS: In a randomized controlled study, 25(OH)D serum levels were measured at enrollment, after 1 week, and after completion of the 12-week period of sunbed use with twice weekly exposure and compared with the control group without any sunbed exposure...
April 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28416343/pigmented-epithelioid-melanocytoma-animal-type-melanoma-an-institutional-experience
#4
Michael J Bax, Marc D Brown, Paul G Rothberg, Todd S Laughlin, Glynis A Scott
BACKGROUND: Pigmented epithelioid melanocytoma (PEM) is an uncommon, recently described entity with unknown biologic behavior. There is a high rate of regional metastases, but limited evidence of distant metastases or disease-related death. OBJECTIVE: We sought to report our series of patients given a diagnosis of PEM at our institution and provide mutational analysis of genes commonly implicated in melanoma in 2 cases. METHODS: The pathology database was queried for cases of PEM diagnosed at the University of Rochester...
April 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28416342/long-term-safety-and-tolerability-of-apremilast-in-patients-with-psoriasis-pooled-safety-analysis-for-%C3%A2-156%C3%A2-weeks-from-2-phase-3-randomized-controlled-trials-esteem-1-and-2
#5
Jeffrey Crowley, Diamant Thaçi, Pascal Joly, Ketty Peris, Kim A Papp, Joana Goncalves, Robert M Day, Rongdean Chen, Kamal Shah, Carlos Ferrándiz, Jennifer C Cather
BACKGROUND: Randomized, controlled trials demonstrated efficacy and safety of apremilast for moderate-to-severe plaque psoriasis and psoriatic arthritis. OBJECTIVE: Assess long-term safety of oral apremilast in psoriasis patients. METHODS: Safety findings are reported for 0 to ≥156 weeks from the Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis (ESTEEM) 1 and 2. RESULTS: The 0 to ≥156-week apremilast-exposure period included 1184 patients treated twice daily with apremilast 30 mg (1902...
April 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28416341/the-role-of-cannabinoids-in-dermatology
#6
EDITORIAL
Jessica S Mounessa, Julia A Siegel, Cory A Dunnick, Robert P Dellavalle
No abstract text is available yet for this article.
April 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28396102/efficacy-of-tofacitinib-for-the-treatment-of-nail-psoriasis-two-52-week-randomized-controlled-phase-3-studies-in-patients-with-moderate-to-severe-plaque-psoriasis
#7
Joseph F Merola, Boni Elewski, Svitlana Tatulych, Shuping Lan, Anna Tallman, Mandeep Kaur
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor. Efficacy and safety of tofacitinib in patients with moderate-to-severe plaque psoriasis have been demonstrated. OBJECTIVE: We sought to assess the efficacy of tofacitinib for the treatment of nail psoriasis over a period of 52 weeks. METHODS: In 2 identical phase 3 studies (OPT Pivotal 1 and 2), patients were randomized 2:2:1 to receive tofacitinib 5 mg, tofacitinib 10 mg, or placebo, twice daily...
April 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28396101/the-effectiveness-of-treatments-for-androgenetic-alopecia-a-systematic-review-and-meta-analysis
#8
REVIEW
Areej Adil, Marshall Godwin
BACKGROUND: Androgenetic alopecia, or male pattern hair loss, is a hair loss disorder mediated by dihydrotestosterone, the potent form of testosterone. Currently, minoxidil and finasteride are Food and Drug Administration (FDA)-approved, and HairMax LaserComb, which is FDA-cleared, are the only treatments recognized by the FDA as treatments of androgenetic alopecia. OBJECTIVE: This systematic review and meta-analysis assesses the efficacy of nonsurgical treatments of androgenetic alopecia in comparison to placebo for improving hair density, thickness, growth (defined by an increased anagen:telogen ratio), or subjective global assessments done by patients and investigators...
April 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28392293/burden-and-treatment-patterns-of-advanced-basal-cell-carcinoma-among-commercially-insured-patients-in-a-united-states-database-from-2010-to-2014
#9
Michael Migden, Jipan Xie, Jin Wei, Wenxi Tang, Vivian Herrera, Jacqueline B Palmer
BACKGROUND: The burden of advanced basal cell carcinoma (aBCC) is not fully understood. OBJECTIVE: To compare BCC disease burden and treatment patterns for aBCC with those for non-aBCC. METHODS: A retrospective, insurance claims-based study design was used. Adults with ≥2 claims associated with a BCC diagnosis (ICD-9-CM 173.x1) separated by ≥30 days on or after October 1, 2011, were classified as aBCC or non-aBCC by using an algorithm based on metastasis diagnosis, radiation therapy use, and medical oncologist/other specialist use...
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28392292/assessment-of-major-comorbidities-in-adults-with-atopic-dermatitis-using-the-charlson-comorbidity-index
#10
Jacob P Thyssen, Lone Skov, Carsten R Hamann, Gunnar H Gislason, Alexander Egeberg
BACKGROUND: There is a growing interest in comorbidities of adults with atopic dermatitis (AD). OBJECTIVES: To examine the burden of comorbidities in adult patients with AD using the Charlson comorbidity index (CCI) in nationwide registries. METHODS: All Danish patients ≥18 years on January 1, 2012 with AD diagnosed by a hospital dermatologist were included. Patients were age-and sex-matched in a 1:4 ratio with general population controls...
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28392291/correction
#11
(no author information available yet)
No abstract text is available yet for this article.
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28392290/association-between-atopic-dermatitis-and-contact-sensitization-a-systematic-review-and-meta-analysis
#12
Carsten R Hamann, Dathan Hamann, Alexander Egeberg, Jeanne D Johansen, Jonathan Silverberg, Jacob P Thyssen
BACKGROUND: It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk. OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD and contact sensitization. METHODS: The PubMed/Medline, Embase, and Cochrane databases were searched for articles that reported on contact sensitization in individuals with and without AD...
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28392289/correlates-of-multiple-basal-cell-carcinoma-in-a-retrospective-cohort-study-sex-histologic-subtypes-and-anatomic-distribution
#13
Karen Y Kuo, Prag Batra, Hyunje G Cho, Shufeng Li, Harvind S Chahal, Kerri E Rieger, Jean Y Tang, Kavita Y Sarin
No abstract text is available yet for this article.
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28392288/fontana-masson-stain-in-fungal-infections
#14
Kelly Leigh West, Alan D Proia, Puja Kumari Puri
BACKGROUND: Fontana-Masson (FM) staining is a histopathology technique used to identify dematiaceous fungi. The result often guides initial species identification and antifungal treatment; however, there is evidence that nondematiaceous fungi might react with this stain. Few studies in the current literature address this issue. OBJECTIVE: Our aim was to classify the FM staining patterns of common fungal pathogens for use by pathologists attempting to accurately identify fungi on histopathologic examination...
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28390737/treatment-of-vitiligo-with-the-topical-janus-kinase-inhibitor-ruxolitinib
#15
Brooke Rothstein, Deep Joshipura, Ami Saraiya, Rana Abdat, Huda Ashkar, Yana Turkowski, Vaneeta Sheth, Victor Huang, Shiu Chung Au, Courtney Kachuk, Nicole Dumont, Alice B Gottlieb, David Rosmarin
BACKGROUND: Existing therapies for vitiligo are limited in efficacy and can be associated with undesirable side effects. Topical Janus kinase inhibitors may offer a new therapeutic option for vitiligo. OBJECTIVE: We sought to assess the role of topical ruxolitinib 1.5% cream, a Janus kinase inhibitor, in vitiligo treatment. METHODS: This 20-week, open-label, proof-of-concept trial of twice-daily topical ruxolitinib 1.5% cream was conducted in 12 patients with a minimum of 1% affected body surface area of vitiligo...
April 5, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28389037/idiopathic-atrophoderma-of-pasini-and-pierini-a-case-study-of-collagen-and-elastin-texture-by-multiphoton-microscopy
#16
Gislaine Vieira-Damiani, Denise Lage, Patrícia Érica Christofoletti Daldon, Caroline Romanelli Tibúrcio Alves, Maria Letícia Cintra, Konradin Metze, Javier Adur, Vitor B Pelegati, Hernandes F Carvalho, Carlos Lenz Cesar
BACKGROUND: The diagnosis of idiopathic atrophoderma of Pasini and Pierini (IAPP) relies on typical clinical features, particularly distinctive pigmented ovular/round depressed plaques. Histologic examination often reveals no obvious changes, but patterns of collagen distribution, using multiphoton imaging and second harmonic generation can help track hidden details of tissue organization contributing to atrophy. OBJECTIVE: To identify histologic features that distinguish IAPP from unaffected skin...
April 4, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28434611/alcohol-intake-and-risk-of-rosacea-in-us-women
#17
Suyun Li, Eunyoung Cho, Aaron M Drucker, Abrar A Qureshi, Wen-Qing Li
BACKGROUND: The epidemiologic association between alcohol and rosacea is unclear and inconsistent based on the previous cross-sectional or case-control studies. OBJECTIVE: We conducted a cohort study to determine the association between alcohol intake and the risk of rosacea in women. METHODS: A total of 82,737 women were included from the Nurses' Health Study II (1991-2005). Information on alcohol intake was collected every 4 years during follow-up...
April 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28377030/the-role-of-wide-local-excision-for-the-treatment-of-severe-hidradenitis-suppurativa-hurley-grade-iii-retrospective-analysis-of-74-patients
#18
Christian Posch, Babak Monshi, Tamara Quint, Igor Vujic, Nikolaus Lilgenau, Klemens Rappersberger
BACKGROUND: Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited. OBJECTIVES: We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction with the cosmetic results. METHODS: Seventy-four patients were enrolled. Outcome measures included Dermatology Life Quality Index responses, disease duration, recurrence, previous therapies, postoperative complications, and satisfaction with cosmetic results...
April 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28366237/correction
#19
(no author information available yet)
No abstract text is available yet for this article.
March 31, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28366236/correction
#20
(no author information available yet)
No abstract text is available yet for this article.
March 31, 2017: Journal of the American Academy of Dermatology
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