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Journal of the American Academy of Dermatology

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https://www.readbyqxmd.com/read/28728872/oropharyngeal-lesions-in-pityriasis-rosea
#1
Giulia Ciccarese, Francesco Broccolo, Alfredo Rebora, Aurora Parodi, Francesco Drago
BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. OBJECTIVE: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728871/phosphodiesterase-type-5-inhibitors-and-risk-of-melanoma-a-meta-analysis
#2
Huilin Tang, Wenting Wu, Shuangshuang Fu, Suodi Zhai, Yiqing Song, Jiali Han
BACKGROUND: The association between phosphodiesterase type 5 (PDE5) inhibitors and melanoma risk is controversial. OBJECTIVE: We quantify the association between use of PDE5 inhibitors and melanoma. METHODS: We systematically searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials.gov for studies that were conducted up to July 13, 2016, and evaluated the association between PDE5 inhibitors and skin cancer...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728870/outpatient-dermatology-consultation-impacts-the-diagnosis-and-management-of-pediatric-oncology-patients-a-retrospective-study
#3
Hannah Song, Sarah N Robinson, Jennifer T Huang
BACKGROUND: The impact of dermatology consultation on the care of children with oncologic conditions is unknown. OBJECTIVE: To review outpatient dermatology visits and the resulting impact on diagnosis and management of pediatric oncology patients. METHOD: Retrospective review of pediatric oncology patients with outpatient dermatology visits at a tertiary care center from 2008 to 2015. RESULTS: The most common dermatologic diagnoses in 516 patients were skin infections (21...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728869/aesthetic-outcome-and-complications-of-simple-interrupted-versus-running-subcuticular-sutures-in-facial-surgery-a-randomized-controlled-trial
#4
Xiaomeng Liu, Patty J Nelemans, Lisa D S Frenk, Helma Sengers, Stephania M H Tuinder, Peter M Steijlen, Klara Mosterd, Nicole W J Kelleners-Smeets
BACKGROUND: The suturing technique and its associated complications could affect cosmetic outcome after facial surgery. Literature on this topic is limited. OBJECTIVE: To compare the cosmetic results 12 months after treatment and complications associated with simple interrupted sutures (SIS) versus running subcuticular sutures (RSS) in facial surgery. METHODS: A randomized, controlled multicenter trial was performed. Adults receiving dermatologic surgery on the face were randomized to receive SIS or RSS for wound closure...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728868/pdl1-expression-in-desmoplastic-melanoma-is-associated-with-tumor-aggressiveness-and-progression
#5
Stefan Kraft, Maria-Teresa Fernandez-Figueras, Nina A Richarz, Keith T Flaherty, Mai P Hoang
BACKGROUND: The prognostic role of programmed death ligand 1 (PDL1), CD8, and forkhead box p3 (FoxP3) expression in desmoplastic melanomas is unclear. METHODS: We correlated PDL1, p53, and Ki-67 expression with CD8(+) and FoxP3(+) immune infiltrates with clinicopathologic variables and patient outcomes in a series of 66 desmoplastic melanomas. RESULTS: Tumoral PDL1 expression (≥25%), which was seen in 21% of patients (14 of 66), significantly correlated with mixed histology, tumor thickness, mitoses, recurrence, and metastasis...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28716437/tumor-programmed-cell-death-ligand-1-expression-correlates-with-nodal-metastasis-in-patients-with-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#6
Juana María García-Pedrero, Pablo Martínez-Camblor, Susana Diaz-Coto, Pablo Munguia-Calzada, Aitana Vallina-Alvarez, Francisco Vazquez-Lopez, Juan Pablo Rodrigo, Jorge Santos-Juanes
BACKGROUND: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 expression has been associated with poor outcome in a wide variety of cancers; however, data in cutaneous squamous cell carcinoma (cSCC) are scarce and conflicting. OBJECTIVE: To investigate the relationship of tumor PD-L1 expression with the clinicopathologic features and prognosis of cSCC...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#7
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28716435/reference-values-for-skin-microanatomy-a-systematic-review-and-meta-analysis-of-ex%C3%A2-vivo-studies
#8
Haoming Xu, Maira Fonseca, Zachary Wolner, Esther Chung, Xinyuan Wu, Shamir Geller, Stephen W Dusza, Antonio P DeRosa, Ashfaq A Marghoob, Klaus J Busam, Allan C Halpern, Michael A Marchetti
BACKGROUND: Few studies have characterized reference values of normal human skin microanatomy parameters. OBJECTIVE: To quantify histologic measurements of epidermal thickness, melanocyte density, hair follicle density, and eccrine gland density as a function of age and anatomic site. METHOD: We searched the PubMed, Embase, Web of Science, and Cochrane databases for articles published through May 25, 2017. Two reviewers independently screened 2016 articles; 327 relevant articles and 151 additional articles found via forward or reference citations underwent full-text review by 1 of 4 reviewers for relevance, data extraction, and critical appraisal...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28711190/role-of-demodex-mite-infestation-in-rosacea-a-systematic-review-and-meta-analysis
#9
Yin-Shuo Chang, Yu-Chen Huang
BACKGROUND: The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE: We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS: Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled...
July 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28709694/early-clinical-manifestations-of-s%C3%A3-zary-syndrome-a-multicenter-retrospective-cohort-study
#10
Aaron R Mangold, Agnieszka K Thompson, Mark D Davis, Ieva Saulite, Antonio Cozzio, Emmanuella Guenova, Emmilia Hodak, Iris Amitay-Laish, Ramon M Pujol, Mark R Pittelkow, Robert Gniadecki
BACKGROUND: Classic Sézary syndrome (SS) is defined by erythroderma, generalized lymphadenopathy, and leukemic blood involvement. Clinical observations suggest that SS begins as a nonerythrodermic disease. OBJECTIVE: To describe the early clinical characteristics of patients with SS. METHODS: A retrospective, multicenter chart review was performed for 263 confirmed cases of SS diagnosed during 1976-2015. RESULTS: Erythroderma was the earliest recorded skin sign of SS in only 25...
July 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28709693/squamous-proliferations-on-the-legs-of-women-qualitative-examination-of-histopathology-tp53-sequencing-and-implications-for-diagnosis-in-a-series-of-30-cases
#11
Christine J Ko, Earl J Glusac, Jennifer M McNiff, Nemanja Rodic, David J Leffell
BACKGROUND: Women with multiple squamous cell carcinomas (SCCs) of the legs have a striking clinical phenotype. Numerous tumors can develop in a short period of time. OBJECTIVE: Because histopathologic findings can vary in women with multiple SCC lesions, from keratoacanthoma-like to well-differentiated SCC, we hypothesized that TP53 variants might shed light on the appropriate classification. METHODS: We sequenced TP53 in 30 SCCs from 6 women who had multiple SCCs on their legs during a 21-month time frame...
July 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28676330/trends-in-prescribing-behavior-of-systemic-agents-used-in-the-treatment-of-acne-among-dermatologists-and-nondermatologists-a-retrospective-analysis-2004-2013
#12
John S Barbieri, William D James, David J Margolis
BACKGROUND: Despite recommendations to limit the use of oral antibiotics and increasing support for hormonal agents in the treatment of acne, it is unclear whether there have been any significant changes in practice patterns. OBJECTIVE: To characterize changes in prescribing behavior for systemic agents in the treatment of acne in the United States between 2004 and 2013. METHODS: We conducted a retrospective analysis using the OptumInsight Clinformatics DataMart (Optum, Eden Prairie, MN)...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28676329/multiple-and-repeated-sampling-increases-the-sensitivity-of-direct-immunofluorescence-testing-for-the-diagnosis-of-mucous-membrane-pemphigoid
#13
Iakov Shimanovich, Julia Marie Nitz, Detlef Zillikens
BACKGROUND: Mucous membrane pemphigoid (MMP) is an autoimmune disease characterized by the predominant blistering of mucosal surfaces and the linear deposition of complement, IgG, or IgA along the basement membrane detected by direct immunofluorescence (DIF) test. OBJECTIVE: To assess the impact of multiple and repeated DIF sampling on establishing the diagnosis of MMP. METHODS: We reviewed the results of DIF studies in 136 nonlesional biopsies from 78 patients who were immunologically confirmed to have MMP...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28676328/cd8-mycosis-fungoides-a-low-grade-lymphoproliferative-disorder
#14
Maria Estela Martinez-Escala, Robert W Kantor, Ahuva Cices, Xiaolong A Zhou, Jason B Kaplan, Barbara Pro, Jaehyuk Choi, Joan Guitart
BACKGROUND: The prognosis of the CD8(+) subtype of mycosis fungoides (MF) is controversial. Although most authors believe that determining the presence of this cell surface antigen has no prognostic value, others have observed a more indolent course for CD8(+) MF compared with CD4(+) MF. OBJECTIVES: To review the cases of CD8(+) MF in the pediatric and adult populations seen at our institution. METHODS: This is a retrospective review of clinical and pathologic data...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28676327/anatomic-mapping-and-clinicopathologic-analysis-of-benign-acral-melanocytic-neoplasms-a-comparison-between-adults-and-children
#15
Na Hee Kim, Yoo Duk Choi, Hyun Ju Seon, Jee-Bum Lee, Sook Jung Yun
BACKGROUND: The clinicopathologic features of benign acral melanocytic neoplasms (BAMNs) remain poorly understood. OBJECTIVE: To define the clinicopathologic features of BAMNs. METHODS: We analyzed clinical data and mapped BAMNs anatomically. We also reviewed the histopathologic features of BAMNs and compared these between adults and children. RESULTS: We included 396 cases of BAMN: 335 adults and 61 children (376 acquired and 20 congenital lesions)...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28676326/discrepancy-between-the-clinical-and-histopathologic-diagnosis-of-soft-tissue-vascular-malformations
#16
Sophie E R Horbach, Amalia M Utami, Lorine B Meijer-Jorna, J H Sillevis Smitt, Phyllis I Spuls, Chantal M A M van der Horst, Allard C van der Wal
BACKGROUND: Soft tissue vascular malformations are generally diagnosed clinically, according to the International Society for the Study of Vascular Anomalies (ISSVA) classification. Diagnostic histopathologic examination is rarely performed. OBJECTIVE: We sought to evaluate the validity of the current diagnostic workup without routinely performed diagnostic histopathology. METHODS: We retrospectively determined whether there were discrepancies between clinical and histopathologic diagnoses of patients with clinically diagnosed vascular malformations undergoing therapeutic surgical resections in our center (2000-2015)...
July 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28666612/nail-findings-in-patients-with-psoriatic-arthritis-a-cross-sectional-study-with-special-reference-to-transverse-grooves
#17
Yukari Zenke, Yuri Ohara, Daiki Kobayashi, Satoru Arai, Mitsumasa Kishimoto, Masato Okada, Hikaru Eto
BACKGROUND: Patients with psoriatic arthritis (PsA) commonly present with nail manifestations; however, little is known about these manifestations. OBJECTIVE: This study investigated whether nail findings can be used to discriminate between PsA and psoriasis without arthritis. METHODS: We performed a retrospective analysis of 118 patients with PsA and 974 patients with psoriasis without arthritis who visited St. Luke's International Hospital (Tokyo, Japan) between July 2003 and February 2015...
June 27, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28666611/treatment-of-xanthelasma-palpebrarum-with-a-1064-nm-q-switched-nd-yag-laser
#18
Jun Khee Heng, Sze Hon Chua, Chee Leok Goh, Suzanne Cheng, Virlynn Tan, Wee Ping Tan
BACKGROUND: Xanthelasma palpebrarum is the most common cutaneous xanthoma characterized by soft, yellow papules or plaques that arise on the periorbital skin. As these lesions can be cosmetically disfiguring, many patients seek medical help to remove these lesions. OBJECTIVE: To determine the effectiveness and minimum number of treatment sessions with a 1064-nm, Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser for the treatment of xanthelasma. METHODS: A retrospective review of patients with xanthelasma consecutively treated with Q-switched Nd:YAG laser was conducted...
June 27, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28651825/prescription-patterns-and-costs-of-acne-rosacea-medications-in-medicare-patients-vary-by-prescriber-specialty
#19
Myron Zhang, Jonathan I Silverberg, Benjamin H Kaffenberger
BACKGROUND: Prescription patterns for acne/rosacea medications have not been described in the Medicare population, and comparisons across specialties are lacking. OBJECTIVE: To describe the medications used for treating acne/rosacea in the Medicare population and evaluate differences in costs between specialties. METHODS: A cross-sectional study was performed of the 2008 and 2010 Centers for Medicare and Medicaid Services Prescription Drug Profiles, which contains 100% of Medicare part D claims...
June 23, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28651824/cryotherapy-to-treat-anogenital-warts-in-nonimmunocompromised-adults-systematic-review-and-meta-analysis
#20
Antoine Bertolotti, Nicolas Dupin, Fabrice Bouscarat, Brigitte Milpied, Christian Derancourt
BACKGROUND: Cryotherapy is one of the most commonly used therapeutic modalities to treat anogenital warts (AGWs), but this treatment was not clearly established in the recent international recommendations. OBJECTIVE: To compare the efficacy and safety of cryotherapy versus other AGW treatments. METHODS: Through a systematic search of 12 electronic databases, we identified 11 randomized controlled trials, screened from database inception through October 2016, that met the inclusion criteria (including immunocompetent adults with AGWs receiving cryotherapy in 1 of the comparison groups)...
June 23, 2017: Journal of the American Academy of Dermatology
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