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Journal of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/30240703/trans-maternal-helicobacter-pylori-exposure-reduces-allergic-airway-inflammation-in-offspring-through-regulatory-t-cells
#1
Andreas Kyburz, Angela Fallegger, Xiaozhou Zhang, Aleksandra Altobelli, Mariela Artola-Boran, Timothy Borbet, Sabine Urban, Petra Paul, Christian Münz, Stefan Floess, Jochen Huehn, Timothy L Cover, Martin J Blaser, Christian Taube, Anne Müller
BACKGROUND: The trans-maternal exposure to tobacco, microbes, nutrients and other environmental factors shapes the fetal immune system through epigenetic processes. The gastric microbe Helicobacter pylori represents an ancestral constituent of the human microbiota that causes gastric disorders on the one hand, and is inversely associated with allergies and chronic inflammatory conditions on the other. OBJECTIVE: Here, we investigate the consequences of trans-maternal exposure to H...
September 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30240702/injury-dysbiosis-and-filaggrin-deficiency-drive-skin-inflammation-via-keratinocyte-il-1%C3%AE-release
#2
Nathan K Archer, Jay-Hyun Jo, Steven K Lee, Dongwon Kim, Barbara Smith, Roger V Ortines, Yu Wang, Mark C Marchitto, Advaitaa Ravipati, Shuting S Cai, Carly A Dillen, Haiyun Liu, Robert J Miller, Alyssa G Ashbaugh, Angad S Uppal, Michiko Oyoshi, Nidhi Malhotra, Sabine Hoff, Luis A Garza, Heidi H Kong, Julia A Segre, Raif S Geha, Lloyd S Miller
BACKGROUND: Atopic dermatitis (AD) is associated with epidermal barrier defects, dysbiosis and skin injury from scratching. In particular, the barrier defective epidermis of AD patients with loss-of-function filaggrin mutations has increased IL-1α and IL-1β levels but the mechanisms by which IL-1α and/or IL-1β are induced and whether they contribute to the aberrant skin inflammation in AD is unknown. OBJECTIVE: We sought to determine the mechanisms by which skin injury, dysbiosis and increased epidermal IL-1α and IL-1β contribute to the development of skin inflammation in a mouse model of injury-induced skin inflammation in filaggrin-deficient mice...
September 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30240701/severe-bronchiolitis-profiles-and-risk-of-developing-recurrent-wheezing-by-age-3-years
#3
Orianne Dumas, Kohei Hasegawa, Jonathan M Mansbach, Ashley F Sullivan, Pedro A Piedra, Carlos A Camargo
BACKGROUND: A better understanding of bronchiolitis heterogeneity may help clarify its relationship with the development of recurrent wheezing and asthma. OBJECTIVES: To identify severe bronchiolitis profiles by a clustering approach, and to investigate for the first time their association with allergy/inflammatory biomarkers; nasopharyngeal microbiota; and development of recurrent wheezing by age 3 years. METHODS: We analyzed data from a prospective, 17-center U...
September 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30227178/bcl2l12-plays-a-critical-role-in-the-development-of-airway-allergy-via-inducing-aberrant-t-helper-2-polarization
#4
Zhi-Qiang Liu, Ying Feng, Li-Hua Mo, Xian-Hai Zeng, Jiang-Qi Liu, Rui-Di Xie, Zhi-Gang Liu, Ping-Chang Yang, Guang-Ji Zhang, Shan-Dong Wu
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma.
September 15, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30218677/hematopoietic-stem-cell-transplantation-for-activated-pi3k%C3%AE-syndrome-who-when-and-how
#5
EDITORIAL
Luigi D Notarangelo
No abstract text is available yet for this article.
September 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30218676/comparison-of-a-new-skin-prick-test-spt-tape-with-the-conventional-spt
#6
Zhengpeng Gong, Zhijie Yang, Ran Wu, Huiping Ye, Min Jia, Nan Zhang, Claus Bachert
The Skin Prick Test Tape delivered bio-equivalent results to the conventional skin prick test for the diagnosis of mite allergen sensitization, offering an easy and standardized application procedure, avoiding cross-contamination and guaranteeing sterility.
September 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30218675/next-generation-anti-s-aureus-vaccines-a-potential-new-therapeutic-option-for-atopic-dermatitis
#7
EDITORIAL
Julianne Clowry, Alan D Irvine, Rachel M McLoughlin
No abstract text is available yet for this article.
September 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30217468/developmental-regulation-of-type-1-and-type-3-ifn-production-and-risk-for-infant-infections-and-asthma-development
#8
Patrick G Holt, Danny Mok, Debasis Panda, Lynnsey Renn, Giulia Fabozzi, Nick H deKlerk, Merci Mh Kusel, Michael Serralha, Elysia M Hollams, Barbara J Holt, Peter D Sly, Ronald L Rabin
BACKGROUND: Virus-associated febrile lower respiratory tract infections (fLRI) during infancy have been identified as risk factors for persistent wheeze development. We hypothesized that variations in innate immune defence capacity during this period, exemplified by production of types 1 and 3 interferons (T1/3IFNs), may be an underlying determinant of risk. OBJECTIVE: To investigate relationships between postnatal development of innate interferon response capacity and susceptibility to early infections and persistent wheeze...
September 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30213627/rhinitis-in-children-and-adolescents-with-asthma-ubiquitous-difficult-to-control-and-associated-with-asthma-outcomes
#9
Alkis Togias, Peter J Gergen, Jack W Hu, Denise C Babineau, Robert A Wood, Robyn T Cohen, Melanie M Makhija, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Rebecca S Gruchalla, Andrew H Liu, Emily Wang, Haejin Kim, Carin I Lamm, Leonard B Bacherier, Dinesh Pillai, Steve M Sigelman, James E Gern, William W Busse
BACKGROUND: Rhinitis and asthma are linked, but substantial knowledge gaps in this relationship exist. OBJECTIVE: To determine the prevalence of rhinitis and its phenotypes in children and adolescents with asthma, assess symptom severity and medication requirements for rhinitis control, and investigate associations between rhinitis and asthma. METHODS: 749 children with asthma participating in the Asthma Phenotypes in the Inner-City study received baseline evaluations and were managed for 1 year with algorithm-based treatments for rhinitis and asthma...
September 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30213626/artemisia-pollen-mugwort-as-a-major-vector-for-ambient-lps-brothers-in-harm
#10
EDITORIAL
Chris Carlsten
No abstract text is available yet for this article.
September 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30213625/advances-in-asthma-in-2017-mechanism-biologics-and-genetics
#11
Mitchell H Grayson, Scott Feldman, Benjamin T Prince, Priya J Patel, Elizabeth C Matsui, Andrea J Apter
This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma...
September 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30205189/anti-il5-treatments-in-severe-asthma-by-blood-eosinophil-thresholds-indirect-treatment-comparison
#12
William Busse, Geoffrey Chupp, Hiroyuki Nagase, Frank C Albers, Scott Doyle, Qin Shen, Daniel J Bratton, Necdet B Gunsoy
BACKGROUND: Three anti-interleukin (IL)5 pathway-directed therapies are approved for use in severe eosinophilic asthma (SEA); however, no head-to-head comparison data are available. OBJECTIVE: To compare the efficacy of licensed doses of mepolizumab, benralizumab and reslizumab in patients with SEA, according to baseline blood eosinophil count. METHODS: This indirect treatment comparison (ITC) used data from a Cochrane review and independent searches...
September 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30205188/lower-perinatal-exposure-to-proteobacteria-is-an-independent-predictor-of-early-childhood-wheezing
#13
Benjamin A Turturice, Diane R Gold, Augusto A Litonjua, Emily Oken, Sheryl Rifas-Shiman, David L Perkins, Patricia W Finn
Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response.
September 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30205187/tobacco-smoke-as-a-risk-factor-for-allergic-sensitization-in-adults-conclusions-of-a-systematic-review-and-meta-analysis
#14
Beatriz Mónico, Jorge M R Gama, M Ramiro Pastorinho, Olga Lourenço
No abstract text is available yet for this article.
September 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30205186/stat5b-deficiency-due-to-a-novel-missense-mutation-in-the-coiled-coil-domain
#15
Meghan J Acres, Florian Gothe, Angela Grainger, Andrew J Skelton, David J Swan, Joseph D P Willet, Suzy Leech, Sonya Galcheva, Violeta Iotova, Sophie Hambleton, Karin R Engelhardt
A novel homozygous missense mutation in the coiled-coil domain of STAT5B causes an immunodeficiency syndrome characterised by short stature due to GH insensitivity, immune dysregulation and hypothyroidism but currently without pulmonary disease or T-cell lymphopenia.
September 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30205185/differential-expression-of-functional-chemokine-receptors-on-human-blood-and-lung-group-2-innate-lymphoid-cells-ilc2s
#16
Cathryn Weston, Batika M J Rana, David J Cousins
Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue.
September 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30201515/the-ige-memory-reservoir-in-food-allergy
#17
EDITORIAL
Rodrigo Jiménez-Saiz, Kelly Bruton, Joshua Fe Koenig, Susan Waserman, Manel Jordana
No abstract text is available yet for this article.
September 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30201514/an-admixture-mapping-meta-analysis-implicates-genetic-variation-at-18q21-with-asthma-susceptibility-in-latinos
#18
Chris R Gignoux, Dara G Torgerson, Maria Pino-Yanes, Lawrence H Uricchio, Joshua Galanter, Lindsey A Roth, Celeste Eng, Donglei Hu, Elizabeth A Nguyen, Scott Huntsman, Rasika A Mathias, Rajesh Kumar, Jose Rodriguez-Santana, Neeta Thakur, Sam S Oh, Meghan McGarry, Andres Moreno-Estrada, Karla Sandoval, Cheryl A Winkler, Max A Seibold, Badri Padhukasahasram, David V Conti, Harold J Farber, Pedro Avila, Emerita Brigino-Buenaventura, Michael Lenoir, Kelley Meade, Denise Serebrisky, Luisa N Borrell, William Rodriguez-Cintron, Shannon Thyne, Bonnie R Joubert, Isabelle Romieu, Albert M Levin, Juan-Jose Sienra-Monge, Blanca Estela Del Rio-Navarro, Weiniu Gan, Benjamin A Raby, Scott T Weiss, Eugene Bleecker, Deborah A Meyers, Fernando J Martinez, W James Gauderman, Frank Gilliland, Stephanie J London, Carlos D Bustamante, Dan L Nicolae, Carole Ober, Saunak Sen, Kathleen Barnes, L Keoki Williams, Ryan D Hernandez, Esteban G Burchard
BACKGROUND: Asthma is a common but complex disease with racial/ethnic differences in prevalence, morbidity, and response to therapies. OBJECTIVE: Perform an analysis of genetic ancestry to identify new loci that contribute to asthma susceptibility. METHODS: We leveraged the mixed ancestry of 3,902 Latinos and performed an admixture mapping meta-analysis for asthma susceptibility. We replicated associations in an independent study of 3,774 Latinos, performed targeted sequencing for fine mapping, and tested for disease correlations with gene expression in the whole blood of >500 individuals from 3 racial/ethnic groups...
September 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30196121/regulatory-t-cell-deficiency-and-autoimmune-skin-disease-beyond-scurfy-mouse-and-ipex
#19
EDITORIAL
Takashi Hashimoto, Hayato Takahashi, Shimon Sakaguchi
No abstract text is available yet for this article.
September 6, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30194992/dupilumab-progressively-improves-systemic-and-cutaneous-abnormalities-in-atopic-dermatitis-patients
#20
Emma Guttman-Yassky, Robert Bissonnette, Benjamin Ungar, Mayte Suárez-Fariñas, Marius Ardeleanu, Hitokazu Esaki, Maria Suprun, Yeriel Estrada, Hui Xu, Xiangyu Peng, Jonathan I Silverberg, Alan Menter, James G Krueger, Rick Zhang, Usman Chaudhry, Brian Swanson, Neil M H Graham, Gianluca Pirozzi, George D Yancopoulos, Jennifer D D Hamilton
BACKGROUND: Dupilumab is an IL-4Rα monoclonal antibody inhibiting signaling of IL-4/IL-13, key drivers of Type 2-driven inflammation, as demonstrated by its efficacy in atopic/allergic diseases. OBJECTIVE: This placebo-controlled, double-blind trial (NCT01979016) evaluated efficacy, safety, and effects of dupilumab on molecular/cellular lesional and nonlesional skin phenotypes and systemic Type 2 biomarkers of moderate-to-severe atopic dermatitis (AD) patients...
September 5, 2018: Journal of Allergy and Clinical Immunology
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