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Journal of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/28433691/direct-monitoring-of-basophil-degranulation-by-using-avidin-based-probes
#1
Régis Joulia, Claire Mailhol, Salvatore Valitutti, Alain Didier, Eric Espinosa
We show that fluorescent avidin binds to basophil cell surface upon degranulation and can be used to set up a new basophil activation test (BAT). This new assay provides results comparable to those provided by the CD63 exposure-based BAT, but has the advantage to directly monitor granule exteriorization.
April 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28433690/asthma-the-past-the-future-the-environment-and-the-costs
#2
EDITORIAL
Eyal Shemesh, Lawrence C Kleinman
No abstract text is available yet for this article.
April 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28433689/type-3-innate-lymphoid-cells-induce-proliferation-of-cd94-nk-cells
#3
Shuo Li, Hideaki Morita, Beate Rückert, Tadech Boonpiyathad, Avidan Neumann, Cezmi Akdis
No abstract text is available yet for this article.
April 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28433688/vitamin-d-downregulates-the-il-23-receptor-pathway-in-human-mucosal-ilc3
#4
Viktoria Konya, Paulo Czarnewski, Marianne Forkel, Anna Rao, Efthymia Kokkinou, Eduardo J Villablanca, Sven Almer, Ulrik Lindforss, Danielle Friberg, Charlotte Höög, Peter Bergman, Jenny Mjösberg
BACKGROUND: Vitamin D deficiency is a risk factor for inflammatory bowel disease (IBD). The IL-23-driven tissue-resident ILC3 play essential roles in intestinal immunity, and targeting IL-23/12 is a promising approach in IBD therapy. OBJECTIVE: We set out to define the role of 1α,25-dihydroxy vitamin D3 (1,25D) in regulating functional responses of human mucosal ILC3 to IL-23 plus IL-1β stimulation. METHODS: Transcriptomes of sorted tonsil ILC3 were assessed by microarray analysis...
April 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28433687/steroid-resistance-of-airway-type-2-innate-lymphoid-cells-ilc2s-from-severe-asthma-the-role-of-thymic-stromal-cell-lymphopoietin-tslp
#5
Sucai Liu, Mukesh Verma, Lidia Michalec, Weimin Liu, Anand Sripada, Donald Rollins, James Good, Yoko Ito, HongWei Chu, Magdalena M Gorska, Richard J Martin, Rafeul Alam
BACKGROUND: ILC2s represent an important type 2 immune cell. Glucocorticoid regulation of human ILC2s is largely unknown. OBJECTIVE: To assess steroid resistance of human blood and airway ILC2s from asthmatic patients and examine its mechanism of induction. METHODS: We studied human blood and lung ILC2s from asthmatic and control subjects by flow cytometry and ELISA. RESULTS: Dexamethasone (Dex) inhibited (P=0.04) CRTH2 and type 2 cytokine expression by blood ILC2s stimulated with IL25 and IL33...
April 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28427879/food-protein-induced-enterocolitis-syndrome-in-australia-a-population-based-study-2012-2014
#6
Sam Mehr, Katie Frith, Elizabeth H Barnes, Dianne E Campbell
BACKGROUND: Food protein induced enterocolitis syndrome (FPIES) is a non-IgE mediated gastrointestinal allergic disorder. Large population based FPIES studies are lacking. OBJECTIVE: To determine the incidence and clinical characteristics of FPIES in Australian infants METHODS: An Australia wide survey (2012-2014) was undertaken via the Australian Paediatric Surveillance Unit, with monthly notification of new cases of acute FPIES in infants aged <24 months by 1400 participating Paediatricians...
April 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28414063/hypersensitivity-transfusion-reactions-due-to-iga-deficiency-are-rare-according-to-french-hemovigilance-data
#7
Charles Tacquard, Karim Boudjedir, Monique Carlier, Jean-Yves Muller, Philippe Gomis, Paul Michel Mertes
In an analysis of a large French hemovigilance database (2004-2014), hypersensitivity transfusion reactions (HTRs) due to IgA deficiency were extremely rare with an frequency far lower than reported so far. In depth investigation of HTRs for IgA deficiency should be limited to moderate to severe recurrent reactions.
April 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28414062/novel-pik3cd-mutations-affecting-n-terminal-residues-of-p110%C3%AE-cause-apds1-in-humans
#8
Andrew J Takeda, Yu Zhang, Gillian L Dornan, Braden D Siempelkamp, Meredith L Jenkins, Helen F Matthews, Joshua J McElwee, Weimin Bi, Filiz O Seeborg, Helen C Su, John E Burke, Carrie L Lucas
APDS is a newly described and prevalent primary immunodeficiency disease, and we now expand the list of mutation sites to include E81K and G124D of p110δ and uncover an intramolecular mechanism of activation that is inhibited by clinically relevant targeting of p110δ.
April 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28414061/mechanistic-correlates-of-clinical-responses-to-omalizumab-in-the-setting-of-oral-immunotherapy-for-milk-allergy
#9
Pamela A Frischmeyer-Guerrerio, Madhan Masilamani, Wenjuan Gu, Erica Brittain, Robert Wood, Jennifer Kim, Kari Nadeau, Kirsi M Jarvinen, Alexander Grishin, Robert Lindblad, Hugh A Sampson
BACKGROUND: In our recent clinical trial, the addition of omalizumab to oral immunotherapy (OIT) for milk allergy improved safety but no significant clinical benefit was detected. OBJECTIVE: To investigate mechanisms by which omalizumab modulates immunity in the context of OIT, and to identify baseline biomarkers that predict subgroups of patients most likely to benefit from omalizumab. METHODS: Blood was obtained at baseline and multiple time-points during a placebo-controlled trial of OIT for milk allergy where subjects were randomized to receive omalizumab or placebo...
April 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28412396/systems-approach-to-uncover-signaling-networks-in-primary-immunodeficiency-diseases
#10
Jeff Choi, Rosemary Fernandez, Holden T Maecker, Manish J Butte
This broad, unbiased approach of studying signaling across all circulating immune cells in healthy subjects allowed identification of disrupted signaling networks in patients with primary immunodeficiencies.
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28412395/severe-asthma-differential-chemokine-response-of-airway-epithelial-cells
#11
Biju Thomas, Robert Anthony Hirst, Mina H Brett-Pitt, Gwyneth Williams, Peter W Andrew, Ana R Sousa, Richard P Marshall, Chrostopher Brightling, Christopher O'Callaghan
The differential chemokine response of airway basal cells of severe asthma patients to Streptococcus pneumoniae and Dermatophagoides pteronyssinus allergen may be of significance in the context of developing novel immunomodulatory therapeutic strategies for atopic asthma.
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28412394/water-soluble-chitosan-inhibits-nerve-growth-factor-and-attenuates-allergic-inflammation-in-mite-allergen-induced-allergic-rhinitis
#12
Pei-Chi Chen, Miao-His Hsieh, PhD Wen-ShuoKuo, Hui-Fan Kao, Chih-Li Hsu, Jiu-Yao Wang
Nerve growth factor induces nasal inflammation by augmenting the existing TH2 immune response, and this can be suppressed bywater-soluble chitosan, a natural, nontoxic product that provides new therapy for allergic rhinitis.
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28412393/adhesion-induced-eosinophil-cytolysis-requires-the-ripk3-mlkl-signaling-pathway-which-is-counter-regulated-by-autophagy
#13
Susanne Radonjic-Hoesli, Xiaoliang Wang, Elisabeth de Graauw, Christina Stoeckle, Beata Styp-Rekowska, Ruslan Hlushchuk, Dagmar Simon, Peter J Spaeth, Shida Yousefi, Hans-Uwe Simon
BACKGROUND: Eosinophils are a subset of granulocytes which can be involved in the pathogenesis of different diseases, including allergy. Their effector functions are closely linked to their cytotoxic granule proteins. The release takes place by several different mechanisms, one of which is cytolysis, which is associated with the release of intact granules, so-called clusters of free eosinophil granules. The mechanism underlying this activation-induced form of cell death in eosinophils has remained unclear...
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28412392/diminished-airway-macrophage-expression-of-the-axl-receptor-tyrosine-kinase-is-associated-with-defective-efferocytosis-in-asthma
#14
Aleksander M Grabiec, Nicholas Denny, John A Doherty, Kaisa E Happonen, Jenny Hankinson, Emma Connolly, Mark E Fife, Toshifumi Fujimori, Naoya Fujino, Anu Goenka, Susan Holden, Gaël Tavernier, Rajesh Shah, Peter C Cook, Andrew S MacDonald, Robert M Niven, Björn Dahlbäck, Stephen J Fowler, Angela Simpson, Tracy Hussell
The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance.
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28412391/moving-towards-endotypes-in-atopic-dermatitis-identification-of-patient-clusters-based-on-serum-biomarker-analysis
#15
Judith Lydia Thijs, Ian Strickland, Catharina Ansfrieda Francisca Maria Bruijnzeel-Koomen, Stefan Nierkens, Barbara Giovannone, Eszter Csomor, Bret Richard Sellman, Tomas Mustelin, Matthew Alexander Sleeman, Marjolein Saskia de Bruin-Weller, Athula Herath, Julia Drylewicz, Richard David May, DirkJan Hijnen
BACKGROUND: Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease with a diverse clinical presentation. It is however unclear whether this diversity exists at a biological level. OBJECTIVE: To test the hypothesis that AD is heterogeneous at the biological level of individual inflammatory mediators. METHODS: Serum from 193 moderate to severe adult AD patients (geomean (95%CI) SASSAD of 22.3 (21.3, 23.3) and 39.1 (37.5, 40...
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28410741/reply
#16
LETTER
Stephen J Galli
No abstract text is available yet for this article.
April 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28410740/serum-ige-as-biomarker-for-predicting-allergen-immunotherapy-effectiveness
#17
LETTER
Giorgio Ciprandi
No abstract text is available yet for this article.
April 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28400115/thymus-transplantation-for-complete-digeorge-syndrome-european-experience
#18
E Graham Davies, Melissa Cheung, Kimberly Gilmour, Jesmeen Maimaris, Joe Curry, Anna Furmanski, Neil Sebire, Neil Halliday, Konstantinos Mengrelis, Stuart Adams, Jolanta Bernatoniene, Ronald Bremner, Michael Browning, Blythe Devlin, Hans Christian Erichsen, H Bobby Gaspar, Lizzie Hutchison, Winnie Ip, Marianne Ifversen, T Ronan Leahy, Elizabeth McCarthy, Despina Moshous, Kim Neuling, Malgorzata Pac, Alina Papadopol, Kathryn L Parsley, Luigi Poliani, Ida Ricciardelli, David M Sansom, Tiia Voor, Austen Worth, Tessa Crompton, M Louise Markert, Adrian J Thrasher
BACKGROUND: Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS). METHODS: Twelve patients with cDGS were transplanted with allogeneic cultured thymus. OBJECTIVE: To confirm and extend the results previously obtained in a single centre. RESULTS: Two patients died of pre-existing viral infections without developing thymopoeisis and one late death occurred from autoimmune thrombocytopaenia...
April 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28400114/autophagy-nobel-prize-2016-and-allergy-and-asthma-research
#19
EDITORIAL
Harald Renz
No abstract text is available yet for this article.
April 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28396074/is-il-1%C3%AE-inhibition-the-next-therapeutic-target-in-asthma
#20
EDITORIAL
R Stokes Peebles
No abstract text is available yet for this article.
April 7, 2017: Journal of Allergy and Clinical Immunology
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