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Journal of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/30012514/human-cystatin-sn-is-an-endogenous-protease-inhibitor-that-prevents-allergic-rhinitis
#1
Ayumi Fukuoka, Kazufumi Matsushita, Taiyo Morikawa, Takumi Adachi, Koubun Yasuda, Hiroshi Kiyonari, Shigeharu Fujieda, Tomohiro Yoshimoto
BACKGROUND: Protease allergens disrupt epithelial barriers to exert their allergenicity. Cystatin SN (encoded by CST1) is an endogenous cysteine protease inhibitor upregulated in nasal epithelia in patients with allergic rhinitis (AR). OBJECTIVE: To investigate the protective effect of human Cystatin SN on AR symptoms using pollen-induced AR mouse models. METHODS: We performed in vitro protease activity assay to evaluate the effect of recombinant human Cystatin SN (rhCystatin SN) on Japanese Cedar (JC) or ragweed proteases...
July 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30012513/artemisia-pollen-is-the-main-vector-for-airborne-endotoxin
#2
Jose Oteros, Elke Bartusel, Francesca Alessandrini, Andrés Núñez, Diego Alejandro Moreno, Heidrun Behrendt, Carsten Schmidt-Weber, Claudia Traidl-Hoffmann, Jeroen Buters
BACKGROUND: Endotoxin (lipopolysaccharides, LPS) released from Gram-negative bacteria causes strong immunologic and inflammatory effects and when airborne may contribute to respiratory conditions such as allergic asthma. OBJECTIVES: To identify the source of airborne endotoxin and the effect of this endotoxin on allergic sensitization. METHODS: We determined LPS in outdoor air on a daily basis for 4 consecutive years in Munich (Germany) and Davos (Switzerland)...
July 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30009843/allograft-rejection-is-associated-with-the-development-of-functional-ige-specific-for-donor-mhc-antigens
#3
Andreas M Farkas, Ulrike Baranyi, Georg A Böhmig, Lukas Unger, Stefan Hopf, Markus Wahrmann, Heinz Regele, Benedikt Mahr, Christoph Schwarz, Karin Hock, Nina Pilat, Ivan Kristo, Jasmin Mraz, Christian Lupinek, Josef Thalhamer, Gregor Bond, Lorenz Kuessel, Elizabeth Wlodek, Jack Martin, Menna Clatworthy, Gavin Pettigrew, Rudolf Valenta, Thomas Wekerle
BACKGROUND: Donor-specific antibodies (DSA) of the IgG isotype are routinely measured for diagnostic purposes in renal transplant recipients and are associated with antibody-mediated rejection and long-term graft loss. OBJECTIVE: This study aimed to investigate if MHC-specific antibodies of the IgE isotype are induced during the rejection of allografts. METHODS: Anti-MHC/HLA IgE was measured in sera of mice grafted with skin or heart transplants from various donor strains and in sera of kidney transplant patients with high levels of HLA-IgG...
July 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29981808/an-integrated-model-of-alopecia-areata-biomarkers-highlights-both-th1-th2-up-regulation
#4
Teresa Song, Ana B Pavel, Huei-Chi Wen, Kunal Malik, Yeriel Estrada, Juana Gonzalez, Peter Hashim, John Nia, Danielle Baum, Grace Kimmel, Giselle K Singer, James G Krueger, Emma Guttman-Yassky
This study expands the current paradigm on AA cytokine profile in serum and scalp, identifying IL-15, and Th1 and Th2 serum cytokines that reflect both tissue activity and clinical disease severity.
July 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29981807/urinary-pgdm-a-prostaglandin-d-2-metabolite-is-a-novel-biomarker-for-objectively-detecting-allergic-reactions-of-food-allergy
#5
Shinichiro Inagaki, Shingo Maeda, Masami Narita, Tatsuro Nakamura, Tatsuo Shimosawa, Takahisa Murata, Yukihiro Ohya
No abstract text is available yet for this article.
July 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29981806/treating-insect-bite-hypersensitivity-ibh-in-horses-by-active-vaccination-against-interleukin-5
#6
EDITORIAL
Albert Y Wu, Sanjiv Sur, J Andrew Grant
No abstract text is available yet for this article.
July 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29981805/outcome-of-domino-hematopoietic-stem-cell-transplantation-in-humans-an-international-case-series
#7
Mirjam E Belderbos, Andrew R Gennery, Christopher C Dvorak, Henric-Jan Blok, Dirk-Jan Eikema, Juliana M F Silva, Paul Veys, Bénédicte Neven, Rebecca Buckley, Theresa Cole, Morton J Cowan, W Scott Goebel, Manfred Hoenig, Caroline Y Kuo, E Richard Stiehm, Robert Wynn, Marc Bierings
This multicenter cohort study demonstrates that at a median follow up of ten years, domino-HSCT results in overall survival of 80%, event-free survival of 49%, and low risk of GvHD. Domino-HSCT can be considered, weighed against other available transplantation strategies.
July 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30010542/calcium-and-zinc-tune-autoinflammatory-toll-like-receptor-4-signaling-by-s100a12
#8
Christoph Kessel, Sabrina Fuehner, Jana Zell, Bastian Zimmermann, Stephan Drewianka, Sonja Brockmeyer, Dirk Holzinger, Claas Hinze, Helmut Wittkowski, Dirk Foell
S100A12 is highly overexpressed in certain autoinflammatory diseases. Here we describe, that upon cellular release Ca2+ and Zn2+ can operate as molecular switch rendering S100A12 into a toll-like receptor 4-ligand to trigger sterile inflammation.
July 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29970235/novel-vaccines-technology-and-development
#9
REVIEW
Sarita U Patil, Wayne G Shreffler
The development and widespread use of vaccines, which are defined by the World Health Organization as "biological preparations that improve immunity to a particular disease," represents one of the most significant strides in medicine. Vaccination was first applied to reduce mortality and morbidity from infectious diseases. The World Health Organization estimates that vaccines prevent 2 to 3 million human deaths annually, and these numbers would increase by at least 6 million if all children received the recommended vaccination schedule...
June 30, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29969634/genetic-variants-with-gene-regulatory-effects-are-associated-with-diisocyanate-asthma
#10
David I Bernstein, Zana L Lummus, Banu Kesavalu, Jianbo Yao, Leah Kottyan, Daniel Miller, André Cartier, Maria-Jesús Cruz, Catherine Lemiere, Xavier Muñoz, Santiago Quirce, Susan Tarlo, Joaquin Sastre, Louis Philippe Boulet, Matthew T Weirauch, Kenneth Kaufman
BACKGROUND: Isocyanates are major causes of occupational asthma but susceptibility and mechanisms of Diisocyanate Asthma (DA) remain uncertain. OBJECTIVE: The aim of this study is to identify DA-associated functional genetic variants via next generation sequencing (NGS), bioinformatics, and functional assays. METHODS: NGS was performed in 91 workers with DA. Fourteen loci with known DA associated single nucleotide polymorphisms (SNPs) were sequenced and compared to data from 238 unexposed subjects...
June 30, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29969633/evaluation-of-food-allergy-candidate-loci-in-the-genetics-of-food-allergy-study
#11
Ingo Marenholz, Sarah Grosche, Franz Rüschendorf, Birgit Kalb, Katharina Blumchen, Rupert Schlags, Neda Harandi, Mareike Price, Gesine Hansen, Jürgen Seidenberg, Songül Yürek, Georg Homuth, Carsten O Schmidt, Markus M Nöthen, Norbert Hubner, Bodo Niggemann, Kirsten Beyer, Young-Ae Lee
A recent genome-wide association study suggested novel candidate loci for food allergy. Apart from the established locus at 11q13, these revealed no association with food allergy in the Genetics Of Food Allergy Study.
June 30, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29966610/oral-corticosteroids-in-preschool-children-with-severe-episodes-of-virus-associated-wheeze-to-treat-or-not-to-treat
#12
EDITORIAL
Avraham Beigelman, Leonard B Bacharier
No abstract text is available yet for this article.
June 29, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29964057/alternaria-is-associated-with-asthma-symptoms-and-exhaled-no-among-nyc-children
#13
Nitzan Soffer, Brett J Green, Luis Acosta, Adnan Divjan, Edward Sobek, Angela R Lemons, Andrew G Rundle, Judith S Jacobson, Inge F Goldstein, Rachel L Miller, Matthew S Perzanowsk
Among NYC children, Alternaria sensitization, even at low IgE concentrations, was associated with asthma morbidity. Domestic Alternaria exposure, which was common, was associated with exhaled NO, specifically among children with higher neighborhood-level combustion air pollution.
June 28, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29964056/atopic-dermatitis-in-chinese-patients-shows-t-h-2-t-h-17-skewing-with-psoriasiform-features
#14
Tom C Chan, Riana D Sanyal, Ana B Pavel, Jacob Glickman, Xiuzhong Zheng, Hui Xu, Yung-Tsu Cho, Tsen-Feng Tsai, Huei-Chi Wen, Xiangyu Peng, Inna Cueto, James G Krueger, Emma Guttman-Yassky
Our data established the molecular fingerprints of AD and psoriasis in Han Chinese patients, and identified tissue biomarkers of disease that correlated with clinical severity.
June 28, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29959948/chitins-and-chitinase-activity-in-airway-diseases
#15
Steven J Van Dyken, Richard M Locksley
Chitin, one of the most abundant biopolymers on earth, is bound and degraded by chitinases, specialized enzymes that are similarly widespread in nature. Chitin catabolism impacts global carbon and nitrogen cycles through a host of diverse biological processes, but recent work has focused attention on systems of chitin recognition and degradation conserved in mammals, connecting an ancient pathway of polysaccharide processing to human diseases influenced by persistent immune triggering. Here, we review current advances in our understanding of how chitin-chitinase interactions impact mucosal immune feedback mechanisms essential to maintaining homeostasis and organ heath...
June 27, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29958676/is-substance-p-a-nasal-epithelial-neuropeptide
#16
LETTER
Steven D Douglas, Susan E Leeman
No abstract text is available yet for this article.
June 26, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29945814/reply
#17
LETTER
Matthew C Altman, James E Gern
No abstract text is available yet for this article.
June 23, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29945813/can-natural-killer-cells-represent-an-early-life-immune-response-in-development-of-allergic-asthma-more-precise-data-analysis-should-be-considered
#18
LETTER
Dan Yang, Chuntao Liu
No abstract text is available yet for this article.
June 23, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29936105/questioning-the-accuracy-of-currently-available-pneumococcal-antibody-testing
#19
Joud Hajjar, Aba Al-Kaabi, Carleigh Kutac, James Dunn, William T Shearer, Jordan S Orange
Clinically significant inter-laboratory differences in Streptococcus pneumoniae antibodies were identified between commercial laboratories. These differences could affect diagnoses and management when assessing humoral deficiencies; thus, commercial laboratory methods should be standardized to obtain similar results.
June 21, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29936104/disrupted-n-linked-glycosylation-as-a-disease-mechanism-in-deficiency-of-ada2
#20
Pui Y Lee, Yuelong Huang, Qing Zhou, Oskar Schnappauf, Michael S Hershfield, Ying Li, Nancy J Ganson, Natalia Sampaio Moura, Ottavia M Delmonte, Scellig S Stone, Michael J Rivkin, Sung-Yun Pai, Todd Lyons, Robert P Sundel, Victor W Hsu, Luigi D Notarangelo, Ivona Aksentijevich, Peter A Nigrovic
Deficiency of adenosine deaminase 2 is characterized by vasculitis, early-onset strokes, immunodeficiency, and bone marrow failure. We describe a novel pathogenic mutation affecting a consensus N-linked glycosylation sequence and illustrate the essential role of glycosylation in the biology of ADA2.
June 21, 2018: Journal of Allergy and Clinical Immunology
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