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Journal of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/30439406/loss-of-an-igg-plasma-cell-checkpoint-in-lupus
#1
Jolien Suurmond, Yemil Atisha-Fregoso, Emiliano Marasco, Ashley N Barlev, Naveed Ahmed, Silvia A Calderon, Mei Yin Wong, Meggan C Mackay, Cynthia Aranow, Betty Diamond
BACKGROUND: IgG anti-nuclear antibodies (ANA) are a feature of several autoimmune diseases. These antibodies arise through defects in central or peripheral tolerance checkpoints. The specific checkpoints breached in autoimmune disease are not fully understood. OBJECTIVES: To study whether autoreactive plasma cells in lupus models and SLE patients arise as a consequence of defective antigen-specific selection or a global enhancement of IgG PC differentiation. METHODS AND RESULTS: We optimized and validated a novel technique to detect naturally occurring ANA+ B cells and PC...
November 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30439405/th9-immunodeficiency-in-hyper-ige-syndrome-patients
#2
EDITORIAL
Matthew R Olson, Mark H Kaplan
No abstract text is available yet for this article.
November 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30439404/cd3-cd4-cd8-mucosal-t-cells-are-associated-with-uncontrolled-chronic-rhinosinusitis-with-nasal-polyps
#3
Tanja Soklic Kosak, Mira Silar, Matija Rijavec, Ana Koren, Izidor Kern, Irena Hocevar Boltezar, Peter Korosec
Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP.
November 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30439403/mast-cell-crf-2-suppresses-mast-cell-degranulation-and-limits-the-severity-of-anaphylaxis-and-stress-induced-intestinal-permeability
#4
Susan D'Costa, Saravanan Ayyadurai, Amelia J Gibson, Emily Mackey, Mrigendra Rajput, Laura J Sommerville, Neco Wilson, Yihang Li, Eric Kubat, Ananth Kumar, Hariharan Subramanian, Aditi Bhargava, Adam J Moeser
BACKGROUND: Psychological stress and heightened MC activation are linked with important immunological disorders including allergy, anaphylaxis, asthma, and functional bowel diseases, but the mechanisms remain poorly defined. We have previously demonstrated that activation of the corticotropin releasing factor (CRF) system potentiates MC degranulation responses during IgE-mediated anaphylaxis and psychological stress, via CRF receptor subtype 1 (CRF1 ) expressed on MCs. OBJECTIVE: In this study, we investigated the role of CRF receptor subtype 2 (CRF2 ) as a modulator of stress-induced MC degranulation and associated disease pathophysiology...
November 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414861/engineering-of-structural-variants-of-the-major-peanut-allergens-ara-h-2-and-ara-h-6-for-allergen-specific-immunotherapy
#5
Merima Bublin, Maria Kostadinova, Christian Radauer, Eva-Maria Varga, Christine Hafner, Klara Schmidthaler, Aziza Saidova, Soheila J Maleki, Zsolt Szépfalusi, Thomas Eiwegger, Heimo Breiteneder
Applying a novel way to design hypoallergens, we produced variants of the major peanut allergens Ara h 2 and Ara h 6 with significantly reduced IgE-binding and basophil activation capacities and preserved T-cell stimulatory activity.
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414860/peak-flow-variability-in-childhood-and-body-mass-index-in-adult-life
#6
Enrico Lombardi, Debra A Stern, Duane Sherrill, Wayne J Morgan, Anne L Wright, Judith Garcia-Aymerich, Ignasi Serra Pons, Stefano Guerra, Fernando D Martinez
Peak flow variability in childhood is a significant and independent predictor of subsequent body mass index increase up to age 26. Shared developmental and genetic factors may explain, at least in part, the association between these two phenotypes.
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414859/identification-of-inhibitory-mechanisms-in-pseudo-allergy-involving-mrgprb2-mrgprx2-mediated-mast-cell-activation
#7
Ayako Takamori, Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Yoko Okamoto, Akie Maehara, Atsushi Tanabe, Masakazu Nagamine, Hiromichi Yamada, Shino Uchida, Koichiro Uchida, Masamichi Isobe, Tomoki Hatayama, Daiki Watanabe, Taiki Ando, Takuma Ide, Moe Matsuzawa, Keiko Maeda, Nobuhiro Nakano, Naoto Tamura, Katsuhisa Ikeda, Nobuyuki Ebihara, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Jiro Kitaura
Ceramide-CD300f binding inhibits mouse Mrgprb2 (human MrgprX2)-mediated mast cell activation, thereby suppressing pseudo-allergic reactions. CD300f could be a therapeutic target against IgE-independent pseudo-allergy as well as IgE-dependent allergy.
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414858/innate-immune-crosstalk-in-asthmatic-airways-innate-lymphoid-cells-coordinate-the-polarization-of-lung-macrophage
#8
Jihyun Kim, Yuna Chang, Boram Bae, Kyoung-Hee Sohn, Sang-Heon Cho, Doo Hyun Chung, Hye Ryun Kang, Hye Young Kim
BACKGROUND: Recent studies have emphasized the role of innate lymphoid cells (ILCs) in the development of asthma. The involvement of group 2 ILCs (ILC2s) in asthma is well studied, however, the participation of other types of ILCs in the development of asthma remains unclear. OBJECTIVE: This study aims to understand the role of various ILCs in the patients with asthma, especially their effect on the polarization of macrophages. METHODS: Each subset of ILCs and macrophages in induced sputum from 51 steroid-naïve asthma patients and 18 healthy donors analyzed by flow cytometry...
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414857/novel-locus-for-atopic-dermatitis-in-african-americans-and-replication-in-european-americans
#9
Berta Almoguera, Lyam Vazquez, Frank Mentch, Michael E March, John J Connolly, Peggy L Peissig, James G Linneman, María Del Carmen Plaza-Serón, Maria Pino-Yanes, Esteban G Burchard, Murray Brilliant, Patrick Sleiman, Hakon Hakonarson
The present study provides the first genetic locus associated with AD in African Americans.
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414856/new-delivery-forms-of-nasal-corticosteroids
#10
EDITORIAL
Wytske Fokkens, Sietze Reitsma
No abstract text is available yet for this article.
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414855/efficacy-and-safety-of-histamine-h-4-receptor-antagonist-zpl-3893787-in-atopic-dermatitis
#11
Thomas Werfel, Gary Layton, Michael Yeadon, Lyndsey Whitlock, Ian Osterloh, Pablo Jimenez, Wai Liu, Victoria Lynch, Aliya Asher, Athanasios Tsianakas, Lynn Purkins
BACKGROUND: Histamine 4 (H4 ) receptor antagonists are potential novel treatments for inflammatory skin diseases including atopic dermatitis (AD). OBJECTIVE: To study the efficacy and safety of ZPL-3893787 (selective H4 receptor antagonist) in moderate/severe AD. METHODS: A randomised, double-blind, placebo-controlled, parallel-group study was conducted to evaluate ZPL-3893787 (30mg) once daily oral therapy in adult patients with moderate/severe AD...
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414854/eosinophil-progenitor-levels-correlate-with-tissue-pathology-in-pediatric-eosinophilic-esophagitis
#12
Justin T Schwartz, David W Morris, Margaret H Collins, Marc E Rothenberg, Patricia C Fulkerson
Blood eosinophil progenitors (EoPs) correlate with tissue pathology during active eosinophilic esophagitis (EoE), providing additional evidence for blood EoP levels as a biomarker for disease activity and suggesting a role for EoPs in EoE pathogenesis.
November 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30414395/human-and-computational-models-of-atopic-dermatitis-a-review-and-perspectives-by-an-expert-panel-of-the-international-eczema-council
#13
Kilian Eyerich, Sara J Brown, Bethany E Perez White, Reiko J Tanaka, Robert Bissonette, Sandipan Dhar, Thomas Bieber, Dirk J Hijnen, Emma Guttman-Yassky, Alan Irvine, Jacob P Thyssen, Christian Vestergaard, Thomas Werfel, Andreas Wollenberg, Amy S Paller, Nick J Reynolds
Atopic dermatitis (AD) is a prevalent disease worldwide associated with systemic co-morbidities, representing a significant burden on individuals, their families and society. Therapeutic options for AD remain limited, in part due to lack of well-characterised animal models. To better define pathophysiological mechanisms and to identify novel therapeutic targets and biomarkers that predict therapeutic response, there has been increasing interest in developing experimental approaches to study the pathogenesis of human AD in vivo, in vitro, and in silico...
November 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30395890/ige-to-galactose-%C3%AE-1-3-galactose-and-the-%C3%AE-gal-syndrome-insights-from-basophil-activation-testing
#14
EDITORIAL
Jeffrey M Wilson, Thomas A E Platts-Mills
No abstract text is available yet for this article.
November 2, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30395889/school-based-interventions-where-do-we-go-from-here
#15
EDITORIAL
Jean-Marie Bruzzese, Meyer Kattan
No abstract text is available yet for this article.
November 2, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30390922/reply
#16
LETTER
Ana Olivera, Dean D Metcalfe
No abstract text is available yet for this article.
October 31, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30390921/effect-of-il-33-on-de-novo-synthesized-mediators-from-human-mast-cells
#17
LETTER
Theoharis C Theoharides, Susan E Leeman
No abstract text is available yet for this article.
October 31, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30389411/epicutaneous-immunotherapy-for-peanut-allergy-modifies-igg-4-responses-to-major-peanut-allergens
#18
Stef J Koppelman, Aurélie Peillon, Wenceslas Agbotounou, Hugh A Sampson, Laurent Martin
Epicutaneous immunotherapy (EPIT) for peanut allergy is an investigational therapy currently in development. This study shows that EPIT induces IgG4 to the major peanut allergens, Ara h 1, h 2, h 3 and h 6.
October 30, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30392720/determination-of-ige-and-igg-reactivity-to-more-than-170-allergen-molecules-in-paper-dried-blood-spots
#19
Victoria Garib, Eva Rigler, Felix Gastager, Raffaela Campana, Yulia Dorofeeva, Pia Gattinger, Yury Zhernov, Musa Khaitov, Rudolf Valenta
No abstract text is available yet for this article.
October 26, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30389226/multicenter-randomized-double-blind-placebo-controlled-clinical-trial-of-vital-wheat-gluten-oral-immunotherapy
#20
Anna Nowak-Węgrzyn, Robert A Wood, Kari C Nadeau, Jacqueline A Pongracic, Alice K Henning, Robert W Lindblad, Kirsten Beyer, Hugh A Sampson
BACKGROUND: Wheat is a common food allergen that can cause anaphylaxis. OBJECTIVE: We sought to determine the efficacy and safety of vital wheat gluten (VWG) oral immunotherapy (OIT). METHODS: After baseline double-blind, placebo-controlled food challenge (DBPCFC), 46 patients with wheat allergy (median age, 8.7 years; range, 4.2-22.3 years) were randomized 1:1 to low-dose VWG OIT or placebo, with biweekly escalation to 1445 mg of wheat protein (WP)...
October 24, 2018: Journal of Allergy and Clinical Immunology
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