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Journal of Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/28093217/abnormal-cd161-immune-cells-and-ror%C3%AE-t-mediated-enhanced-il-17f-expression-in-genetic-hypertension
#1
Madhu V Singh, Michael Z Cicha, Santosh Kumar, David K Meyerholz, Kaikobad Irani, Mark W Chapleau, François M Abboud
BACKGROUND: Hypertension is considered an immunological disorder. However, the role of IL-17 family in genetic hypertension of the spontaneously hypertensive rat (SHR) has not been investigated. OBJECTIVE: We tested the hypothesis that enhanced Th17 programming and IL-17 expression in abundant CD161+ immune cells in SHR represent an abnormal proinflammatory adaptive immune response. Furthermore, we propose that this response is driven by the master regulator RORγt and a nicotinic proinflammatory innate immune response...
January 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28093216/longitudinal-variation-of-serum-periostin-in-adults-with-stable-asthma
#2
Ruth Semprini, Rachel Caswell-Smith, James Fingleton, Cecile Holweg, John Matthews, Mark Weatherall, Richard Beasley, Irene Braithwaite
We have shown that serum periostin levels are stable within an individual with well-controlled asthma and have little seasonal variation. These are desirable characteristics if serum periostin is to be used as a biomarker in asthma.
January 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28089873/patterns-of-immune-development-in-urban-preschoolers-with-recurrent-wheeze-and-or-atopy
#3
James E Gern, Agustin Calatroni, Katy F Jaffee, Henry Lynn, Amy Dresen, William W Cruikshank, Howard M Lederman, Hugh A Sampson, Wayne Shreffler, Leonard B Bacharier, Peter J Gergen, Diane R Gold, Meyer Kattan, George T O'Connor, Megan T Sandel, Robert A Wood, Gordon R Bloomberg
BACKGROUND: Disadvantaged urban children have high rates of allergic diseases and wheezing, which are diseases associated with Type 2-biased immunity. OBJECTIVE: To determine whether environmental exposures in early life influence cytokine responses which affect the development of recurrent wheezing illnesses and allergic sensitization. METHODS: A birth cohort of 560 urban families was recruited from neighborhoods with high rates of poverty, and 467 (83%) children were followed until 3 years of age...
January 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28089871/parents-childhood-socioeconomic-circumstances-are-associated-with-their-children-s-asthma-outcomes
#4
Edith Chen, Madeleine U Shalowitz, Rachel E Story, Katherine B Ehrlich, Erika M Manczak, Paula J Ham, Van Le, Gregory E Miller
BACKGROUND: Previous literature documents associations between low socioeconomic status (SES) and poor health outcomes, including asthma. However, this literature has largely focused on the effects of current family circumstances. OBJECTIVE: To test an intergenerational hypothesis, that the childhood SES that parents experience will be associated with asthma outcomes in their children, independent of effects of current family SES. Secondly, to test whether this association is in part due to difficulties in current parent-child relationships...
January 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28089872/identification-of-airway-mucosal-type-2-inflammation-by-clinical-biomarkers-in-asthma
#5
Philip E Silkoff, Michel Laviolette, Dave Singh, J Mark FitzGerald, Steven Kelsen, Vibeke Backer, Celeste M Porsbjerg, Pierre-Olivier Girodet, Patrick Berger, Joel N Kline, Geoffrey Chupp, Vedrana S Susulic, Elliot S Barnathan, Frédéric Baribaud, Matthew J Loza
BACKGROUND AND OBJECTIVE: The Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study profiled mild, moderate and severe asthma, and non-atopic healthy controls. We explored this dataset to define Type-2 inflammation based on airway-mucosal IL-13-driven gene expression and how this related to clinically-accessible biomarkers. METHODS: IL-13-driven gene expression was evaluated in several human cell lines. We then defined Type-2 status in 25 healthy subjects, 28 mild, 29 moderate, and 26 severe asthmatics, based on airway-mucosal expression of 1) CC-motif chemokine ligand (CCL)-26, (the most differentially expressed gene), 2) periostin, or 3) a multi-gene IL-13 in-vitro signature (IVS)...
January 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28088474/diagnostic-accuracy-of-fractional-exhaled-nitric-oxide-in-predicting-cough-variant-asthma-and-eosinophilic-bronchitis-in-adult-patients-with-chronic-cough-a-systematic-review-and-meta-analysis
#6
Woo-Jung Song, Hyun Jung Kim, Ji-Su Shim, Ha-Kyeong Won, Sung-Yoon Kang, Kyoung-Hee Sohn, Byung-Keun Kim, Eun-Jung Jo, Min-Hye Kim, Sang-Heon Kim, Heung-Woo Park, Sun-Sin Kim, Yoon-Seok Chang, Alyn H Morice, Byung-Jae Lee, Sang-Heon Cho
BACKGROUND: Individual studies suggested the utility of fractional exhaled nitric oxide (FeNO) in detecting cough variant asthma (CVA) and eosinophilic bronchitis (EB) in chronic cough patients. OBJECTIVE: To obtain summary estimates of diagnostic test accuracy of FeNO in predicting CVA and/or EB in adult patients with chronic cough METHODS: Electronic databases were searched for studies published until January 2016, without language restriction. Cross-sectional studies which reported the diagnostic accuracy of FeNO for detecting CVA or EB were included...
January 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28088336/human-basophils-may-not-undergo-modulation-by-dc-sign-and-mannose-receptor-targeting-immunotherapies-due-to-absence-of-receptors
#7
LETTER
Mrinmoy Das, Caroline Galeotti, Emmanuel Stephen-Victor, Anupama Karnam, Srini V Kaveri, Jagadeesh Bayry
No abstract text is available yet for this article.
January 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28088335/reply
#8
LETTER
Oscar Palomares, José Luis Subiza
No abstract text is available yet for this article.
January 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087328/identification-of-drug-and-drug-metabolite-immune-responses-originating-from-both-na%C3%A3-ve-and-memory-t-cells
#9
Andrew Gibson, Lee Faulkner, Sally Wood, B Kevin Park, Dean J Naisbitt
Both naïve and memory T-cells from drug-naive donors can be stimulated by parent drug and drug haptens. Thus, drug-derived antigens can stimulate naïve T-cells alongside pre-existing memory T-cells through proposed heterologous immunity with an as yet undetermined peptide antigen.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087327/ige-cross-linking-impairs-monocyte-antiviral-responses-and-inhibits-influenza-driven-th1-differentiation
#10
Regina K Rowe, David M Pyle, Andrew R Tomlinson, Tinghong Lv, Zheng Hu, Michelle A Gill
IgE-mediated allergic activation impairs the virus-induced Th1 lymphocyte priming capacity of human monocytes in response to influenza exposure. These findings represent one potential mechanism contributing to the link between viral infections and allergic disease.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087326/autoimmune-lymphoproliferative-syndrome-caused-by-homozygous-fas-mutations-with-normal-or-residual-protein-expression
#11
Nourhen Agrebi, Lamia Ben Mansour, Moez Medhaffar, Sondes Hadiji, Faten Fedhila, Meriem Ben-Ali, Najla Mekki, Mongia Hachicha, Sihem Barsaoui, Mohamed-Ridha Barbouche, Imen Ben-Mustapha
The identification of homozygous FAS mutations with normal or residual protein expression expands the spectrum of autoimmune lymphoproliferative syndrome types and should prompt clinicians to search for such patients particularly in highly endogamous populations.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087325/does-size-really-matter-relationship-of-particle-size-to-lung-deposition-and-exhaled-fraction
#12
Sunny Jabbal, Gianluigi Poli, Brian Lipworth
We demonstrate that extra-fine particles are not associated with an appreciably higher exhaled fraction, hence explaining their efficacy profile in asthma.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087228/insights-into-the-mast-cell-microbiome-connection-in-the-skin
#13
EDITORIAL
Alon Y Hershko
No abstract text is available yet for this article.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087226/pathways-to-limit-group-2-innate-lymphoid-cell-activation
#14
EDITORIAL
Taylor A Doherty, David H Broide
No abstract text is available yet for this article.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087225/assessing-the-therapeutic-index-of-inhaled-corticosteroids-in-children-is-knemometry-the-answer
#15
EDITORIAL
H William Kelly
No abstract text is available yet for this article.
January 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28081849/constitutive-high-expression-of-protein-arginine-methyltransferase-1-in-asthmatic-airway-smooth-muscle-cells-is-caused-by-reduced-microrna-19a-expression-and-leads-to-enhanced-remodeling
#16
Qingzhu Sun, Li Liu, Hui Wang, Jyotshna Mandal, Petra Khan, Katrin E Hostettler, Daiana Stolz, Michael Tamm, Antonio Molino, Didier Lardinois, Shemin Lu, Michael Roth
BACKGROUND: In asthma remodeling airway smooth muscle cells (ASMCs) contribute to airway wall thickness through increased proliferation, migration, and extracellular matrix deposition. Previously, we described that protein arginine methyltransferase 1 (PRMT1) participates in airway remodeling in pulmonary inflammation in E3 rats. OBJECTIVE: We sought to define the asthma-specific regulatory mechanism of PRMT1 in human ASMCs. METHODS: ASMCs from healthy subjects and asthmatic patients were activated with platelet-derived growth factor (PDGF)-BB...
January 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28069426/impaired-nk-cell-functions-in-patients-with-stat1-gain-of-function-mutations
#17
Giovanna Tabellini, Donatella Vairo, Omar Scomodon, Nicola Tamassia, Rosalba Monica Ferraro, Ornella Patrizi, Sara Gasperini, Annarosa Soresina, Giuliana Giardino, Claudio Pignata, Vassilios Lougaris, Alessandro Plebani, Laura Dotta, Marco A Cassatella, Silvia Parolini, Raffaele Badolato
BACKGROUND: Gain-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of the Signal Transducer and Activator of Transcription 1 (STAT1) cause chronic mucocutaneous candidiasis disease (CMCD). This condition is characterized by fungal and bacterial infections due to impaired generation of Th17 cells; meanwhile some CMCD patients may also develop viral or intracellular pathogens infections. OBJECTIVE: To Investigate the effect of GOF-STAT1 mutations on functioning of Natural Killer (NK) cells...
January 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28069425/an-epigenome-wide-association-study-of-total-serum-immunoglobulin-e-in-hispanic-children
#18
Wei Chen, Ting Wang, Maria Pino-Yanes, Erick Forno, Liming Liang, Qi Yan, Donglei Hu, Daniel E Weeks, Andrea Baccarelli, Edna Acosta-Perez, Celeste Eng, Yueh-Ying Han, Nadia Boutaoui, Catherine Laprise, Gwyneth A Davies, Julian M Hopkin, Miriam F Moffatt, William O C M Cookson, Glorisa Canino, Esteban G Burchard, Juan C Celedón
BACKGROUND: Total immunoglobulin E (IgE) is a therapeutic target in allergic diseases. DNA methylation in white blood cells (WBCs) was associated with total IgE in an epigenome-wide association study (EWAS) of Caucasians. Whether DNA methylation of eosinophils explains those findings is insufficiently understood. METHODS: We tested for association between genome-wide DNA methylation in WBCs and total IgE in two studies of Hispanic children: the Puerto Rico Genetics of Asthma and Lifestyle Study (PR-GOAL, n = 306) and the Genes-environments and Admixture in Latino Americans (GALA II, n = 573)...
January 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28087227/a-novel-kindred-with-inherited-stat2-deficiency-and-severe-viral-illness
#19
Leen Moens, Lien Van Eyck, Dirk Jochmans, Tania Mitera, Glynis Frans, Xavier Bossuyt, Patrick Matthys, Johan Neyts, Michael Ciancanelli, Shen-Ying Zhang, Rik Gijsbers, Jean-Laurent Casanova, Stephanie Boisson-Dupuis, Isabelle Meyts, Adrian Liston
No abstract text is available yet for this article.
January 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28065678/construction-and-validation-of-a-novel-disease-specific-quality-of-life-instrument-for-patients-with-primary-antibody-deficiency-disease-padqol-16
#20
Mark Ballow, Mark R Conaway, Panida Sriaroon, Rima A Rachid, Filiz O Seeborg, Carla M Duff, Francisco A Bonilla, M Elizabeth M Younger, Ralph Shapiro, Ted M Burns
A disease-specific Health-related Quality of Life survey was developed for adult patients with antibody immune deficiency disorders as a tool (PADQOL-16) for assessing a patient's QOL issues and their relation to clinical status.
January 5, 2017: Journal of Allergy and Clinical Immunology
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