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JOURNAL ARTICLE
Stéphane De Wit, Fabrice Bonnet, Olayemi Osiyemi, Fiona Bisshop, Julian Olalla, Jean-Pierre Routy, Christoph Wyen, Riya Moodley, Keith Pappa, Ruolan Wang, James Oyee, Parminder Saggu, Emilio Letang, Brian Wynne, Bryn Jones, Kimberly Y Smith, Mounir Ait-Khaled
BACKGROUND: Switching to the 2-drug regimen dolutegravir/lamivudine demonstrated durable non-inferior efficacy vs continuing 3- or 4-drug tenofovir alafenamide-based regimens for maintaining virologic suppression in people with HIV-1 through Week 144 in TANGO. SETTING: 134 centers, 10 countries. METHODS: Adults with HIV-1 RNA <50 copies/mL for >6 months and no history of virologic failure were randomized to switch from stable tenofovir alafenamide-based regimens to dolutegravir/lamivudine on Day 1 (early-switch group) for 196 weeks...
February 8, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#22
JOURNAL ARTICLE
Nicky J Mehtani, Alix Strough, Sarah Strieff, Barry Zevin, Joanna Eveland, Elise D Riley, Monica Gandhi
BACKGROUND: Long-acting (LA) antiretrovirals may provide meaningful benefit to people who use drugs and people experiencing homelessness (PEH) who face disproportionate structural and psychosocial barriers in adhering to daily oral HIV antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP), but their use in these populations has not been studied. SETTING: The Maria X. Martinez Health Resource Center is a low-barrier (e.g., no appointment) community-based clinic serving San Francisco PEH...
February 8, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#23
JOURNAL ARTICLE
Hacer Deniz Özkaya, Khaled Elazab, Bülent Turan, Arzu Nazlı, Barçın Öztürk, Hüsnü Pullukçu, Deniz Gökengin
BACKGROUND: Late diagnosis of HIV infection is a major global problem. In Turkiye, only 41% - 50% of people living with HIV (PLWH) are diagnosed, suggesting that many opportunities for HIV testing might be missed. SETTING: The aim of this study is to determine the missed testing opportunities for HIV in healthcare settings in Turkiye and the predictors for missed opportunities (MOs). METHODS: The study included patients with a new HIV diagnosis, presenting to care between January 2018 and December 2020...
February 8, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#24
JOURNAL ARTICLE
Ethel Rambiki, Tom Heller, Claudia Wallrauch, Matthew Painschab, Jacquiline Huwa, Jennipher Khalani, Kelvin Rambiki
No abstract text is available yet for this article.
February 7, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#25
JOURNAL ARTICLE
Eteri Machavariani, Janet Miceli, Frederick L Altice, Robyn Neblett Fanfair, Suzanne Speers, Lisa Nichols, Heidi Jenkins, Merceditas Villanueva
BACKGROUND: Re-engaging people with HIV (PWH) who are newly out-of-care remains challenging. Data-to-care (D2C) is a potential strategy to re-engage such individuals. METHODS: A prospective randomized controlled trial compared a D2C strategy using a disease intervention specialist (DIS) vs standard-of-care (SOC) where 23 HIV clinics in 3 counties in Connecticut could re-engage clients using existing methods. Using a data reconciliation process to confirm being newly out-of-care, 655 participants were randomized to DIS (N=333) or SOC (N=322)...
February 7, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#26
JOURNAL ARTICLE
Karl Reis, Allison Wolf, Rubeshan Perumal, Boitumelo Seepamore, Kevin Guzman, Jesse Ross, Ken Cheung, K Rivet Amico, James C M Brust, Nesri Padayatchi, Gerald Friedland, Kogieleum Naidoo, Amrita Daftary, Jennifer Zelnick, Max O'Donnell
INTRODUCTION: For people living with HIV/AIDS, care is commonly delivered through Differentiated Service Delivery (DSD). Although people with multidrug-resistant tuberculosis (MDR-TB) and HIV/AIDS experience severe treatment associated challenges, there is no DSD model to support their treatment. In this study, we defined patterns of medication adherence and characterized longitudinal barriers to inform development of an MDR-TB/HIV DSD framework. METHODS: Adults with MDR-TB and HIV initiating bedaquiline (BDQ) and receiving antiretroviral therapy (ART) in KwaZulu-Natal, South Africa, were enrolled and followed through the end of MDR-TB treatment...
February 6, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#27
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#28
JOURNAL ARTICLE
Jienchi Dorward, Yukteshwar Sookrajh, Richard Lessells, Elliot Bulo, Nicola Bodley, Lavanya Singh, Pravikrishnen Moodley, Natasha Samsunder, Paul K Drain, Gail Hayward, Christopher C Butler, Nigel Garrett
Supplemental Digital Content is Available in the Text.
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#29
JOURNAL ARTICLE
Jane Kabami, Catherine A Koss, Helen Sunday, Edith Biira, Marilyn Nyabuti, Laura B Balzer, Shalika Gupta, Gabriel Chamie, James Ayieko, Elijah Kakande, Melanie C Bacon, Diane Havlir, Moses R Kamya, Maya Petersen
BACKGROUND: Pregnant and postpartum women in Sub-Saharan Africa are at high risk of HIV acquisition. We evaluated a person-centered dynamic choice intervention for HIV prevention (DCP) among women attending antenatal and postnatal care. SETTING: Rural Kenya and Uganda. METHODS: Women (aged 15 years or older) at risk of HIV acquisition seen at antenatal and postnatal care clinics were individually randomized to DCP vs. standard of care (SEARCH; NCT04810650)...
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#30
JOURNAL ARTICLE
Boris Tchakounte Youngui, Daniel Atwine, David Otai, Anca Vasiliu, Bob Ssekyanzi, Colette Sih, Rogacien Kana, Rinah Arinaitwe, Benjamin Cuer, Leonie Simo, Richard Okello, Patrice Tchendjou, Martina Casenghi, Albert Kuate Kuate, Stavia Turyahabwe, Jennifer Cohn, Maryline Bonnet, Boris Kevin Tchounga
INTRODUCTION: People living with HIV are considered at higher risk of developing severe forms of tuberculosis (TB) disease. Providing HIV testing to TB-exposed people is therefore critical. We present the results of integrating HIV testing into a community-based intervention for household TB contact management in Cameroon and Uganda. METHODS: Trained community health workers visited the households of index patients with TB identified in 3 urban/semiurban and 6 rural districts or subdistricts as part of a cluster-randomized trial and provided TB screening to all household contacts...
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#31
JOURNAL ARTICLE
Starley B Shade, Sarah A Gutin, Emily Agnew, Jessica S Grignon, Hailey Gilmore, Mary-Jane Ratlhagana, Jeri Sumitani, Wayne T Steward, Sheri A Lippman
INTRODUCTION: Large proportions of people living with HIV (PLHIV) in sub-Saharan Africa are not linked to or retained in HIV care. There is a critical need for cost-effective interventions to improve engagement and retention in care and inform optimal allocation of resources. METHODS: We estimated costs associated with a short message service (SMS) plus peer navigation (SMS+PN) intervention; an SMS-only intervention; and standard of care (SOC), within the I-Care cluster-randomized trial to improve HIV care engagement for recently diagnosed PLHIV...
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#32
JOURNAL ARTICLE
Winnie Fu, Elisabeth McClymont, Gal Av-Gay, Marisa Dorling, Andrea Atkinson, Arezou Azampanah, Chelsea Elwood, Laura Sauvé, Julie van Schalkwyk, Tatiana Sotindjo, Deborah Money
BACKGROUND: For pregnant women living with HIV (WLWH), engagement in care is crucial to maternal health and reducing the risk of perinatal transmission. To date, there have been no studies in Canada examining the impact of the COVID-19 pandemic on pregnant WLWH. METHODS: This was a retrospective cohort study assessing the impact of the pandemic on perinatal outcomes for pregnant WLWH using data from the Perinatal HIV Surveillance Program in British Columbia, Canada...
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#33
JOURNAL ARTICLE
Mostafa Hossam El Din Moawad, Mahmoud Mohamed Mohamed Shalaby, Esraa Hamouda, Amany Mahfouz, Adel Mouffokes, Heba Hamouda, Abdallah Abbas, Hussien Ahmed H Abdelgawad
BACKGROUND: Despite advancements in the management of HIV infection, the factors contributing to stroke development among HIV-positive individuals remain unclear. This systematic review and meta-analysis aim to identify and evaluate the relative risk factors associated with stroke susceptibility in the HIV population. METHODS: A comprehensive search was conducted in PubMed, Scopus, and Web of Science databases to identify studies investigating the risk of stroke development in HIV patients and assessing the role of different risk factors, including hypertension, diabetes, dyslipidemia, smoking, sex, and race...
April 15, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#34
JOURNAL ARTICLE
Caitlin E Kennedy, Ping T Yeh, Annette Verster, Niklas Luhmann, Van T T Nguyen, Maeve B de Mello, Rachel Baggaley, Virginia Macdonald
BACKGROUND: Key populations are disproportionately affected by HIV, viral hepatitis (VH), and sexually transmitted infections (STIs) and face barriers to care. Peer navigation programs are widely used, but evidence supporting their use has not been synthesized. SETTING: Peer navigation programs for sex workers, men who have sex with men, people who inject drugs, prisoners, and trans and gender diverse people globally. METHODS: To inform World Health Organization guidelines, we conducted a systematic review of effectiveness, values and preferences, and cost studies published between January 2010 and May 2021...
April 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#35
RANDOMIZED CONTROLLED TRIAL
Jonathan E Volk, Wendy A Leyden, Alexandra N Lea, Catherine Lee, Michelle C Donnelly, Douglas S Krakower, Kristine Lee, Vincent X Liu, Julia L Marcus, Michael J Silverberg
BACKGROUND: Preexposure prophylaxis (PrEP) use remains limited and inequitable, and strategies are needed to improve PrEP provision in primary care. METHODS: We conducted a cluster randomized trial at Kaiser Permanente, San Francisco, to evaluate the effectiveness of a clinical decision support intervention guided by an electronic health record (EHR)-based HIV risk prediction model to improve PrEP provision. Primary care providers (PCPs) were randomized to usual care or intervention, with PCPs who provide care to people with HIV balanced between arms...
April 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#36
JOURNAL ARTICLE
Anne Marie France, Nivedha Panneer, Paul G Farnham, Alexandra M Oster, Alex Viguerie, Chaitra Gopalappa
BACKGROUND: Clusters of rapid HIV transmission in the United States are increasingly recognized through analysis of HIV molecular sequence data reported to the National HIV Surveillance System. Understanding the full extent of cluster networks is important to assess intervention opportunities. However, full cluster networks include undiagnosed and other infections that cannot be systematically observed in real life. METHODS: We replicated HIV molecular cluster networks during 2015-2017 in the United States using a stochastic dynamic network simulation model of sexual transmission of HIV...
April 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#37
JOURNAL ARTICLE
Naeemah Z Logan, Peter H Kilmarx, Italia Rolle, Hetal K Patel, Yen T Duong, Kiwon Lee, Judith D Shang, Stephane Bodika, Isabelle T Koui, Shirish Balachandra, Michelle Li, Kristin Brown, Harriet Nuwagaba-Biribonwoha, Yimam Getaneh, Sileshi Lulseged, Ashenafi Haile, Christine A West, Yohannes Mengistu, Stephen D McCracken, Thokozania Kalua, Andreas Jahn, Evelyn Kim, Nellie Wadonda-Kabondo, Sasi Jonnalagadda, Ndapewa Hamunime, Daniel B Williams, James McOllogi Juma, George S Mgomella, Rennatus Mdodo, Wilford L Kirungi, Veronicah Mugisha, Clement B Ndongmo, Kennedy Chibeta Nkwemu, Owen Mugurungi, John H Rogers, Suzue Saito, Paul Stupp, Jessica E Justman, Andrew C Voetsch, Bharat S Parekh
BACKGROUND: HIV testing is a critical step to accessing antiretroviral therapy (ART) because early diagnosis can facilitate earlier initiation of ART. This study presents aggregated data of individuals who self-reported being HIV-positive but subsequently tested HIV-negative during nationally representative Population-Based HIV Impact Assessment surveys conducted in 11 countries from 2015 to 2018. METHOD: Survey participants aged 15 years or older were interviewed by trained personnel using a standard questionnaire to determine HIV testing history and self-reported HIV status...
April 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#38
JOURNAL ARTICLE
Leonardo Calza, Maddalena Giglia, Pierluigi Viale
No abstract text is available yet for this article.
March 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#39
JOURNAL ARTICLE
Andrew W McCrary, Frances Hung, Michael C Foster, Myra Koech, Joan Nekesa, Nathan Thielman, Hrishikesh Chakraborty, Gerald S Bloomfield, Winstone Nyandiko
No abstract text is available yet for this article.
March 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#40
JOURNAL ARTICLE
Dorean Nabukalu, Constantin T Yiannoutsos, Aggrey Semeere, Beverly S Musick, Teddy Murungi, Jane Viola Namulindwa, Francis Waswa, Gertrude Nakigozi, Nelson K Sewankambo, Steven J Reynolds, Tom Lutalo, Fredrick Makumbi, Godfrey Kigozi, Fred Nalugoda, Kara Wools-Kaloustian
BACKGROUND: Monitoring and evaluation of clinical programs requires assessing patient outcomes. Numerous challenges complicate these efforts, the most insidious of which is loss to follow-up (LTFU). LTFU is a composite outcome, including individuals out of care, undocumented transfers, and unreported deaths. Incorporation of vital status information from routine patient outreach may improve the mortality estimates for those LTFU. SETTINGS: We analyzed routinely collected clinical and patient tracing data for individuals (15 years or older) initiating antiretroviral treatment between January 2014 and December 2018 at 2 public HIV care clinics in greater Rakai, Uganda...
March 1, 2024: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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