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Journal of Acquired Immune Deficiency Syndromes: JAIDS

Timothy C Lin, Maartje Dijkstra, Godelieve J De Bree, Maarten F Schim van der Loeff, Martin Hoenigl
OBJECTIVE: Dijkstra and colleagues recently described a risk- and symptom-based score moderately predictive for HIV seroconversion in the preceding 6 to 12 months in men who have sex with men (MSM) in Amsterdam. Our objective was to determine whether this "Amsterdam Score" could also predict for acute HIV infection (AHI) in MSM. DESIGN: and Setting: This study is a case-control analysis of a prospectively enrolled cohort of MSM who voluntarily presented for HIV testing in San Diego...
July 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Deborah Kacanek, Paige L Williams, Gloria Mayondi, Penny Holding, Jean Leidner, Kebaiphe Moabi, Vicki Tepper, Sharon Nichols, Joseph Makhema, Haruna Jibril, Tebogo Maididimalo, Roger Shapiro, Shahin Lockman, Betsy Kammerer
BACKGROUND: In utero exposure to nucleoside reverse transcriptase inhibitor (NRTI)-containing antiretroviral treatment (ART) regimens may be associated with poor neurodevelopmental functioning in children of HIV-infected mothers. We investigated neurodevelopmental outcomes of HIV-exposed uninfected (HEU) children of HIV-infected women enrolled in a randomized trial of abacavir/zidovudine/lamivudine (Triple-NRTI regimen) vs. lopinavir/ritonavir/zidovudine/lamivudine (Dual NRTI+PI regimen)...
July 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Corrina Moucheraud, Dennis Chasweka, Mike Nyirenda, Alan Schooley, Kathryn Dovel, Risa M Hoffman
BACKGROUND: To meet global AIDS goals, pediatric HIV diagnosis must be strengthened. Provider-initiated counseling and testing, which is recommended by the WHO, faces persistent implementation challenges in low-resource settings. Alternative approaches are needed. SETTING: Malawi has achieved high coverage of HIV diagnosis and treatment, but there are gaps among pediatric populations. This study assessed the sensitivity and specificity of a brief screening tool to identify at-risk pediatric patients for targeted HIV testing in Malawi...
July 9, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Felicia C Chow, Huanling Wang, Yanling Li, Natasha Mehta, Yinghuan Hu, Yang Han, Jing Xie, Wei Lu, Weihai Xu, Taisheng Li
No abstract text is available yet for this article.
July 9, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Marcelo Chen, Yung-Feng Yen, Yu-Ching Lan, I-An Jen, Pei-Hung Chuang, Chun-Yuan Lee, Yun Lee, Yu-An Lin, Yi-Ming Arthur Chen
OBJECTIVE: Diffuse infiltrative lymphocytosis syndrome (DILS) is the term used for sicca syndrome in HIV patients and has similar clinical manifestations as Sjögren syndrome (SS). In this nationwide population-based study, we aimed to determine the association between HIV infection and DILS in the Taiwanese population. METHODS: The National Health Insurance Research Database was searched for cases of DILS in HIV-infected individuals diagnosed between January 1, 2000 and December 31, 2012...
July 9, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
David M MacDonald, Anne C Melzer, Gary Collins, Anchalee Avihingsanon, Kristina Crothers, Nicholas E Ingraham, Henry Mugerwa, Matti Ristola, Jonathan Shuter, Ken M Kunisaki
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability globally. Both cigarette smoking and HIV have been identified as independent risk factors for COPD. We used data from the Strategic Timing of Antiretroviral Treatment (START) Pulmonary Substudy to quantify the impact of smoking on rate of lung function decline in HIV. METHODS: We included START Pulmonary Substudy participants who contributed at least two good quality spirometry measures during the study...
July 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Elaine Chang, Srikar R Mapakshi, Pamela Mbang, Nader Kim El-Mallawany, Jennifer R Kramer, Donna L White, Elizabeth Y Chiao
BACKGROUND: Protease inhibitors (PIs) may inhibit Kaposi sarcoma (KS) carcinogenesis. However, PI-based antiretroviral therapy (ART) is rarely a first-line choice in people living with HIV (PLWH) because of cost and toxicities. This is the first systematic review to assess KS incidence stratified by ART type. METHODS: We searched PubMed to identify original, full research reports of KS incidence in ART-treated adult PLWH, stratified by ART class, published between 1996 and 2017...
July 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Edith Apondi, John M Humphrey, Edwin Sang, Ann Mwangi, Alfred Keter, Beverly S Musick, Fred K Nalugoda, John Ssali, Elizabeth Bukusi, Constantin T Yiannoutsos, Kara Wools-Kaloustian, Samuel Ayaya
BACKGROUND: The data needed to understand the characteristics and outcomes, over time, of adolescents enrolling in HIV care in East Africa are limited. SETTING: Six HIV care programs in Kenya, Tanzania, and Uganda. METHODS: This retrospective cohort study included individuals enrolling in HIV care as younger adolescents (10-14 years) and older adolescents (15-19 years) from 2001-2014. Descriptive statistics were used to compare groups at enrollment and antiretroviral therapy (ART) initiation over time...
July 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ingrid V Bassett, Ai Xu, Sabina Govere, Hilary Thulare, Simone C Frank, Christina Psaros, Robert A Parker
No abstract text is available yet for this article.
July 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Czarina N Behrends, Ann V Nugent, Don C Des Jarlais, Jemima A Frimpong, David C Perlman, Bruce R Schackman
No abstract text is available yet for this article.
July 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Yinfeng Zhang, Mariya V Sivay, Sarah E Hudelson, William Clarke, Autumn Breaud, Jing Wang, Estelle Piwowar-Manning, Yaw Agyei, Jessica M Fogel, Erica L Hamilton, Amanda Selin, Catherine MacPhail, Kathleen Kahn, F Xavier Gomez-Olive, James P Hughes, Audrey Pettifor, Susan H Eshleman
BACKGROUND: Antiretroviral (ARV) drugs are used for HIV treatment and prevention. We analyzed ARV drug use and HIV drug resistance in a cohort of young women in rural South Africa enrolled in the HPTN 068 study, which evaluated use of a cash transfer conditional on school attendance to reduce HIV incidence. METHODS: ARV drug testing was performed using plasma samples from 2,526 young women. This included 2,526 enrollment samples (80 HIV-infected, 2,446 HIV-uninfected) and 162 seroconversion samples (first HIV-positive study visit)...
July 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Andreas D Knudsen, Marco Gelpi, Shoaib Afzal, Andreas Ronit, Ashley Roen, Amanda Mocroft, Jens Lundgren, Børge Nordestgaard, Henrik Sillesen, Anne-Mette Lebech, Lars Køber, Klaus F Kofoed, Susanne Dam Nielsen
OBJECTIVE: Ankle-brachial index (ABI) is an excellent tool for diagnosing peripheral artery disease (PAD). We aimed to determine the prevalence and risk factors for PAD in people living with HIV (PLWH) compared to uninfected controls. We hypothesized that prevalence of PAD would be higher among PLWH than among controls independent of traditional cardiovascular disease (CVD) risk factors. METHODS: PLWH aged ≥40 were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study...
July 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Thijs Reyniers, Christiana Nöstlinger, Marie Laga, Irith De Baetselier, Tania Crucitti, Kristien Wouters, Bart Smekens, Jozefien Buyze, Bea Vuylsteke
BACKGROUND: Daily and event-driven Pre-Exposure Prophylaxis (PrEP) are efficacious in reducing HIV transmission among men who have sex with men (MSM). We analysed baseline data from a PrEP demonstration project 'Be-PrEP-ared' in Antwerp, Belgium to understand preferences for daily or event-driven PrEP among MSM at high risk for HIV, and factors influencing their initial choice. METHODS: Cross-sectional data from an open-label prospective cohort study, using mixed methods...
June 29, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Robert H Paul, Sarah A Cooley, Paola M Garcia-Egan, Beau M Ances
OBJECTIVE: The present study examined the relative contribution of cognitive status to frailty among older individuals infected with human immunodeficiency virus (HIV+). DESIGN: Participants included 122 HIV+ individuals (mean age = 57.5 (6.6)) with a median CD4 cell count of 546. Undetectable viral load (< 50 copies per mL) was observed in 94% of the sample. The sample was defined as frail (n=21) and non-frail (n=101) according to the Fried phenotype criteria...
June 26, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Alfredo Tagarro, Man Chan, Paola Zangari, Bridget Ferns, Caroline Foster, Anita De Rossi, Eleni Nastouli, María Angeles Muñoz-Fernández, Diana Gibb, Paolo Rossi, Carlo Giaquinto, Abdel Babiker, Claudia Fortuny, Riccardo Freguja, Nicola Cotugno, Ali Judd, Antoni Noguera-Julian, María Luisa Navarro, María José Mellado, Nigel Klein, Paolo Palma, Pablo Rojo
BACKGROUND: Future strategies aiming to achieve HIV-1 remission are likely to target individuals with small reservoir size. SETTING: We retrospectively investigated factors associated with HIV-1 DNA levels in European, perinatally HIV-infected children starting ART <6 months of age. METHODS: Total HIV-1 DNA was measured from 51 long-term suppressed children 6.3 years (median) after initial viral suppression. Factors associated with log10 total HIV-1 DNA were analyzed using linear regression...
June 26, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Elena Chiappini, Luisa Galli, Catiuscia Lisi, Clara Gabiano, Susanna Esposito, Vania Giacomet, Carlo Giaquinto, Osvalda Rampon, Raffaele Badolato, Orazio Genovese, Wilma Buffolano, Patrizia Osimani, Monica Cellini, Stefania Bernardi, Anna Maccabruni, Icilio Dodi, Filippo Salvini, Giacomo Faldella, Michele Quercia, Cristina Gotta, Marco Rabusin, Fabio Natale, Antonio Mazza, Mara Merighi, Pier-Angelo Tovo, Maurizio de Martino
BACKGROUND: Strategies for prevention of HIV-1 mother-to-child transmission (PMTCT) have been continuously optimized. However, cases of vertical transmission continue to occur in high income countries. OBJECTIVES: To investigate changes in PMTCT strategies adopted by Italian clinicians over time and to evaluate risk factors for transmission. METHODS: Data from mother-child pairs prospectively collected by the Italian Register, born in Italy in 1996-2016, were analyzed...
June 26, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Genevieve Kerkerian, Mary Kestler, Allison Carter, Lu Wang, Nadine Kronfli, Paul Sereda, Eric Roth, M-J Milloy, Neora Pick, Deborah Money, Kath Webster, Robert S Hogg, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida
BACKGROUND: In North America, women have lower engagement across the HIV cascade of care compared with men. Among women living with HIV (WLWH) in Canada, we measured the prevalence and correlates of attrition across cascade stages overall, and by key sub-populations. METHODS: We analyzed baseline survey data regarding six nested stages of the HIV cascade among 1,424 WLWH enrolled in the Canadian HIV Sexual and Reproductive Health Cohort Study (CHIWOS), including: linked to care, retained in care, initiated antiretroviral therapy (ART), current ART use, ART adherence (≥90%), and viral suppression (<50 copies/mL)...
June 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Nicole G Campos, Naomi Lince-Deroche, Carla J Chibwesha, Cynthia Firnhaber, Jennifer S Smith, Pam Michelow, Gesine Meyer-Rath, Lise Jamieson, Suzette Jordaan, Monisha Sharma, Catherine Regan, Stephen Sy, Gui Liu, Vivien Tsu, Jose Jeronimo, Jane J Kim
BACKGROUND: Women with HIV face an increased risk of human papillomavirus (HPV) acquisition and persistence, cervical intraepithelial neoplasia, and invasive cervical cancer. Our objective was to determine the cost-effectiveness of different cervical cancer screening strategies among women with HIV in South Africa. METHODS: We modified a mathematical model of HPV infection and cervical disease to reflect co-infection with HIV. The model was calibrated to epidemiologic data from HIV-infected women in South Africa...
June 15, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Guilherme Amaral Calvet, Patricia Brasil, Andre Machado Siqueira, Heruza Einsfeld Zogbi, Bianca de Santis Gonçalves, Aline da Silva Santos, Otilia Lupi, Rogerio Valls de Souza, Cintia Damasceno Dos Santos Rodrigues, Clarisse da Silveira Bressan, Mauymi Duarte Wakimoto, Eliane Saraiva de Araújo, Ingrid Cardoso Dos Santos, Ingebourg Georg, Rita Maria Ribeiro Nogueira, Valdilea Gonçalves Veloso, Ana Maria Bispo de Filippis
BackgroundZika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. OBJECTIVES: We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients.MethodsHIV-infected patients aged ≥ 18 years with clinical suspected arboviral disease from an ongoing cohort were followed from February through December 2015...
June 14, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
S A Hart, S Vardhanabhuti, S A Strobino, L J Harrison
IntroductionThe Stanford HIV-1 genotypic resistance interpretation algorithm has changed substantially over its lifetime. In many studies the algorithm version used is not specified. It is easy to assume results across versions are comparable, but the effects of version changes on resistance calls are unknown. We evaluate these effects for 20 antiretroviral drugs.MethodsWe calculated resistance interpretations for the same 5,993 HIV-1 sequences, from participants in AIDS Clinical Trials Group studies, under 14 versions of the Stanford algorithm from 2002 to 2017...
June 14, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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