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Journal of Acquired Immune Deficiency Syndromes: JAIDS

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https://www.readbyqxmd.com/read/29140874/hiv-and-age-do-not-synergistically-affect-age-related-t-cell-markers
#1
Shelli Farhadian, Emilie Jalbert, Yanhong Deng, Matthew Bidwell Goetz, Lesley S Park, Amy Justice, Robert Dubrow, Brinda Emu
INTRODUCTION: Despite major progress in controlling HIV disease through anti-retroviral therapy (ART), changes in immune phenotype and function persist in individuals with chronic HIV, raising questions about accelerated aging of the immune system. METHODS: We conducted a cross sectional study (2005-2007) of HIV-infected (n=111) and uninfected (n=114) males from the Veterans Aging Cohort Study. All HIV-infected subjects were on ART with VL<400 copies/mL for at least three years...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140873/experienced-hiv-related-stigma-in-healthcare-and-community-settings-mediated-associations-with-psychosocial-and-health-outcomes
#2
Emma Sophia Kay, Whitney S Rice, Kaylee B Crockett, Ghislaine C Atkins, D Scott Batey, Bulent Turan
INTRODUCTION: There are multiple dimensions of HIV-related stigma that can compromise the mental and physical health of people living with HIV (PLWH). We focused on the dimension of experienced stigma, defined as exposure to acts of discrimination, devaluation, and prejudice, and investigated its relationship with HIV health and psychosocial outcomes. METHODS: We examined associations between experienced stigma in the community and healthcare settings and psychosocial and health outcomes for PLWH (N=203) receiving care at an urban HIV clinic in the Southeastern United States...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140872/an-experimental-investigation-of-implicit-hiv-and-prep-stigma-evidence-for-ancillary-benefits-of-prep-use
#3
Sarit A Golub, Corina Lelutiu-Weinberger, Anthony Surace
BACKGROUND: PrEP stigma (i.e., negative attitudes toward PrEP users) has been widely documented and is considered a significant barrier to implementation. However, few studies have examined PrEP stigma using implicit measures designed to reduce demand characteristics in responding. This study examined implicit PrEP- and HIV-related stigma among gay and bisexual men using geospatial social networking applications (i.e., "hookup apps"). METHODS: Participants were presented with four simulated online profiles (pre-tested for comparability) paired with each of the following characteristics: HIV-negative, HIV-positive, on PrEP, or Substance User...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140871/hiv-prevalence-and-associated-risk-factors-among-men-who-have-sex-with-men-in-dar-es-salaam-tanzania
#4
Elia John Mmbaga, Kåre Moen, Germana Henry Leyna, Rose Mpembeni, Melkizedeck Thomas Leshabari
INTRODUCTION: Limited studies and differential risk behaviours among men who have sex with men(MSM) in Africa calls for population specific studies. We present results from the largest integrated bio-behavioural survey among MSM in Africa to inform programming. METHODS: This was a cross-sectional study utilizing respondent driven sampling to recruit MSM aged 18 and above. Data on socio-demographic characteristics and HIV-related risks were collected and all participants were tested for HIV, Herpes Simplex Virus Type-2 (HSV-2), Hepatitis-B Virus (HBV) and Syphilis...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29140875/bone-mineral-density-declines-twice-as-quickly-among-hiv-infected-women-compared-to-men
#5
Kristine M Erlandson, Jordan E Lake, Myung Sim, Julian Falutz, Carla M Prado, Ana Rita Domingues da Silva, Todd T Brown, Giovanni Guaraldi
BACKGROUND: Initial declines in bone mineral density (BMD) following antiretroviral therapy (ART) initiation in HIV are well described, but data on long-term changes and risk factors for decline, particularly among women, are limited. METHODS: HIV-infected men and women in the Modena Metabolic Clinic underwent dual-energy X-ray absorptiometry (DXA) scans every 6-12 months for up to 10 years (median 4.6 years). Mixed effect regression model in combined and sex-stratified models determined annual rates of decline and clinical factors associated with BMD...
November 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135652/are-hiv-seroconversions-among-young-men-who-have-sex-with-men-associated-with-social-network-proximity-to-recently-or-long-term-hiv-infected-individuals
#6
Ethan Morgan, Britt Skaathun, Rebeccah Duvoisin, Stuart Michaels, John A Schneider
Debate remains as to the relative HIV transmission contributions from individuals who are recently HIV infected and individuals who have long-term infections. In this study, we examine the relationship between new HIV seroconversions occurring among young Black men who have sex with men (YBMSM) and network proximity to recently or long-term HIV infected individuals. A cohort of YBMSM (N = 618) was generated through respondent driven sampling across three waves. A recent HIV infection was defined as either: 1) a confirmed seroconversion ≤9 months prior to interview date or 2) a laboratory confirmed acute infection; long-term HIV infected individuals were defined as a diagnosis date ≥9 months prior to interview date...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135650/pathways-from-hiv-related-stigma-to-antiretroviral-therapy-measures-in-the-hiv-care-cascade-for-women-living-with-hiv-in-canada
#7
Carmen H Logie, Ashley Lacombe-Duncan, Ying Wang, Angela Kaida, Tracey Conway, Kath Webster, Alexandra de Pokomandy, Mona R Loutfy
BACKGROUND: Associations between HIV-related stigma and reduced anti-retroviral (ART) adherence are widely established, yet the mechanisms accounting for this relationship are underexplored. There has been less attention to HIV-related stigma and its associations with ART initiation and current ART use. We examined pathways from HIV-related stigma to ART initiation, current ART use, and ART adherence among women living with HIV in Canada. METHODS: We utilized baseline survey data from a national cohort of women living with HIV in Canada (n=1425)...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135651/comparison-of-the-pharmacokinetics-and-pharmacodynamics-of-single-dose-tenofovir-vaginal-film-and-gel-formulation-fame-05
#8
Jennifer A Robinson, Mark A Marzinke, Edward J Fuchs, Rahul P Bakshi, Hans M L Spiegel, Jenell S Coleman, Lisa C Rohan, Craig W Hendrix
OBJECTIVE: While pre-exposure prophylaxis with oral tenofovir (TFV) disoproxil fumarate/emtricitabine reduces HIV acquisition rates, poor adherence to and acceptability of daily vaginal gels has led to development of vaginal film formulations to improve adherence and, potentially, enable episodic use. STUDY DESIGN: In this two-arm, cross-over study of a fast-dissolving tenofovir film (40 mg) compared to a previously studied semisolid tenofovir 1% gel (40 mg), 10 healthy women received a single vaginal dose of each study product...
November 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135656/frequency-of-monitoring-kidney-function-in-hiv-uninfected-persons-using-daily-oral-tenofovir-disoproxil-fumarate-pre-exposure-prophylaxis
#9
Kenneth K Mugwanya, Jared M Baeten, Christina Wyatt, Nelly R Mugo, Connie L Celum, Allan Ronald, John Kiarie, Elly Katabira, Renee Heffron
BACKGROUND: Wide-scale implementation of oral tenofovir-based pre-exposure prophylaxis (PrEP) for HIV prevention is now policy in many settings. However, the optimal frequency for monitoring kidney function remains uncertain. We investigated the impact of 6-monthly compared to 3-monthly creatinine clearance (CrCl) monitoring on the identification of moderate kidney dysfunction, defined as CrCl <60 mL/min. METHODS: Data were from two prospective daily oral PrEP studies in Kenya and Uganda: the Partners PrEP Study, a randomized safety and efficacy trial of PrEP that conducted 3-monthly CrCl monitoring (n=4404) and the Partners Demonstration Project (n=954), an open-label delivery study of PrEP that used 6-monthly monitoring...
November 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135655/neutrophil-activation-and-enhanced-release-of-granule-products-in-hiv-tb-immune-reconstitution-inflammatory-syndrome
#10
Justine K Nakiwala, Naomi F Walker, Collin R Diedrich, William Worodria, Graeme Meintjes, Robert J Wilkinson, Harriet Mayanja-Kizza, Robert Colebunders, Luc Kestens, Katalin A Wilkinson, David M Lowe
BACKGROUND: Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) remains incompletely understood. Neutrophils are implicated in tuberculosis pathology but detailed investigations in TB-IRIS are lacking. We sought to further explore the biology of TB-IRIS and in particular the role of neutrophils. SETTING: Two observational, prospective cohort studies in HIV/TB co-infected patients starting antiretroviral therapy, one to analyze gene expression and subsequently one to explore neutrophil biology...
November 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135654/cost-effectiveness-of-peer-versus-venue-based-approaches-for-detecting-undiagnosed-hiv-among-heterosexuals-in-high-risk-new-york-city-neighborhoods
#11
Elizabeth R Stevens, Kimberly Nucifora, Qinlian Zhou, R Scott Braithwaite, Charles M Cleland, Amanda S Ritchie, Alexandra H Kutnick, Marya V Gwadz
INTRODUCTION: We used a computer simulation of HIV progression and transmission to evaluate the cost-effectiveness of a scale-up of three strategies to seek out and test individuals with undiagnosed HIV in New York City (NYC). SETTING: Hypothetical NYC population METHODS:: We incorporated the observed effects and costs of the three "seek and test" strategies in a computer simulation of HIV in NYC, comparing a scenario in which the strategies were scaled up with a one-year implementation or a long-term implementation with a counterfactual scenario with no scale-up...
November 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135653/people-born-in-non-main-english-speaking-countries-are-less-likely-to-start-hiv-treatment-early-in-australia-a-national-cohort-analysis-2014-15
#12
P Gunaratnam, H McManus, L Watchirs-Smith, S McGregor, D Callander, G Brown, R Lobo, C C O'Connor, M Hellard, N Medland, D Lewis, C Palmer, M Law, R Gray, B Donovan, R Guy
No abstract text is available yet for this article.
November 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29112043/coercion-and-hiv-self-testing-in-men-who-have-sex-with-men-implementation-data-from-a-cross-sectional-survey-in-china
#13
Jason J Ong, Haochu Li, Wu Dan, Hongyun Fu, Ewen Liu, Wei Ma, Dianmin Kang, Meizhen Liao, Gifty Marley, Chongyi Wei, Weiming Tang, Stephen Pan, Chuncheng Liu, Nicola Desmond, Bin Yang, Ligang Yang, Shujie Huang, Joseph D Tucker
No abstract text is available yet for this article.
November 2, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29112042/network-viral-load-a-critical-metric-for-hiv-elimination
#14
Britt Skaathun, Aditya S Khanna, Ethan Morgan, Samuel R Friedman, John A Schneider
BACKGROUND: Associations have been observed between an aggregate viral load measure, the community viral load (CVL) and new HIV diagnoses. The CVL aggregates viral loads within chosen geographic areas, restricting inferences about HIV acquisition risk to these areas. We develop a more precise metric, the Network Viral Load (NVL) to measure the composite viral load within a risk network of an HIV negative individual. METHODS: We examined the relationship between NVL and HIV infection among Young Men who have Sex with Men (YMSM) in Chicago, United States...
November 2, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29112041/alcohol-and-mortality-combining-self-reported-audit-c-and-biomarker-detected-peth-alcohol-measures-among-hiv-infected-and-uninfected
#15
Oghenowede Eyawo, Kathleen A McGinnis, Amy C Justice, David A Fiellin, Judith A Hahn, Emily C Williams, Adam J Gordon, Brandon D L Marshall, Kevin L Kraemer, Stephen Crystal, Julie R Gaither, E Jennifer Edelman, Kendall J Bryant, Janet P Tate
BACKGROUND: Unhealthy alcohol use may be particularly detrimental among individuals living with HIV and/or HCV, and is often under-reported. Direct biomarkers of alcohol exposure may facilitate improved detection of alcohol use. METHODS: We evaluated the association of alcohol exposure determined by both self-report (Alcohol Use Disorders Identification Test-Consumption [AUDIT-C]) and a direct biomarker (phosphatidylethanol [PEth]), with mortality among HIV-infected and uninfected in the VACS-Biomarker Cohort...
November 2, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29084047/infection-by-htlv-1-is-associated-with-high-levels-of-pro-inflammatory-cytokines-in-hiv-hcv-coinfected-patients
#16
Carlos Brites, Marcos Abrahão, Patrícia Bozza, Eduardo M Netto, André Lyra, Fabianna Bahia
OBJECTIVES: HIV, HCV, and HTLV-1 share the same routes of infection, making coinfection by these viruses a frequent finding in endemic areas. However, there is scarce information on the clinical / immunological consequences of triple infection. Coinfection by HTLV-1 is able to modulate cytokine´s production in HIV patients, but there is no data on the immune response of HIV-HCV-HTLV-1 infected patients METHODS:: we compared the plasma levels of 25 different cytokines in HIV-HCV patients, according to their serostatus to HTLV-1 infection...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29084046/using-clinical-notes-and-natural-language-processing-for-automated-hiv-risk-assessment
#17
Daniel J Feller, Jason Zucker, Michael T Yin, Peter Gordon, Noémie Elhadad
OBJECTIVE: Universal HIV screening programs are costly, labor-intensive, and often fail to identify high-risk individuals. Automated risk assessment methods that leverage longitudinal electronic health records (EHRs) could catalyze targeted screening programs. While social and behavioral determinants of health are typically captured in narrative documentation, previous analyses have considered only structured EHR fields. We examined whether natural language processing (NLP) would improve predictive models of HIV diagnosis...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29084045/declining-baseline-viraemia-and-escalating-discordant-hiv-1-confirmatory-results-within-south-africa-s-early-infant-diagnosis-program-2010-2016
#18
Ahmad Haeri Mazanderani, Faith Moyo, Tendesayi Kufa, Gayle G Sherman
OBJECTIVE: To describe baseline HIV-1 RNA viral load (VL) trends within South Africa's Early Infant Diagnosis (EID) program 2010-2016, with reference to prevention of mother-to-child transmission (PMTCT) guidelines. METHODS: HIV-1 total nucleic acid polymerase chain reaction (TNA PCR) and RNA VL data from 2010-2016 were extracted from the South African National Health Laboratory Service's central data repository. Infants with a positive TNA PCR and subsequent baseline RNA VL taken at age <7 months were included...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29084044/evolving-models-and-ongoing-challenges-for-hiv-pre-exposure-prophylaxis-implementation-in-the-united-states
#19
Kenneth H Mayer, Philip A Chan, Rupa Patel, Charlene A Flash, Douglas S Krakower
BACKGROUND: The use of pre-exposure prophylaxis (PrEP) for HIV prevention was approved by the FDA in 2012, but delivery to at risk persons has lagged. This critical review analyzes the current state of PrEP implementation in the US, by reviewing barriers, and innovative solutions, to enhanced PrEP access and uptake. SETTING: Clinical care settings, public health progrlams and community-based organizations (CBOs). METHODS: Critical review of recent peer-reviewed literature...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29084043/partnerships-between-a-university-affiliated-clinic-and-community-based-organizations-to-reach-black-men-who-have-sex-with-men-for-prep-care
#20
Meredith E Clement, N Lance Okeke, Terry Munn, Miguel Hunter, Kareem Alexis, Amy Corneli, Arlene C Seña, Kara McGee, Mehri S McKellar
No abstract text is available yet for this article.
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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