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Journal of Acquired Immune Deficiency Syndromes: JAIDS

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https://www.readbyqxmd.com/read/28107229/is-prep-needed-for-msm-in-west-africa-hiv-incidence-in-a-prospective-multi-country-cohort
#1
Clotilde Couderc, Bintou Dembélé Keita, Camille Anoma, Abdoulaye S Wade, Alou Coulibaly, Sylvain Ehouman, Abdou K Diop, Yves Yomb, Emilie Henry, Bruno Spire, Christian Laurent
No abstract text is available yet for this article.
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28107228/contribution-of-oxidative-stress-to-non-aids-events-in-hiv-infected-patients
#2
Mar Masiá, Sergio Padilla, Marta Fernández, Xavier Barber, Santiago Moreno, José Antonio Iribarren, Joaquín Portilla, Alejandro Peña, Francesc Vidal, Félix Gutiérrez
OBJECTIVE: Recognition of potentially modifiable mechanisms implicated in the pathogenesis of non-AIDS events (NAEs) might help improve outcomes of HIV-infected individuals. HIV infection has been associated with increased oxidative stress. We assessed the association between F2-isoprostanes and serious NAEs, and whether they improve the predictive performance of inflammation and coagulation biomarkers. METHODS: Prospective multicenter cohort. Individuals who had an incident serious NAE and two sex and age matched participants with no events were selected...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28107227/structural-level-differences-in-the-mother-to-child-hiv-transmission-rate-in-south-africa-a-multilevel-assessment-of-individual-health-facility-and-provincial-level-predictors-of-infant-hiv-transmission
#3
S Woldesenbet, D J Jackson, C J Lombard, T H Dinh, V Ramokolo, T Doherty, G G Sherman, Y Pillay, A E Goga
OBJECTIVES: In 2010, South Africa reported an early mother to child transmission (MTCT) rate of 3.5% at 4-8 weeks postpartum. Provincial early MTCT rates ranged from 1.4% (95% confidence interval [CI]: 0.1-3.4%) to 5.9% (95% CI: 3.8-8.0%). We sought to determine reasons for these geographic differences in MTCT rates. METHODS: This study employed multilevel modelling using 2010 South African PMTCT evaluation (SAPMTCTE) data from 530 facilities. Interview data and infant blood samples were collected from 3085 mother-infant pairs at 4-8 weeks postpartum...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28107226/evaluation-of-a-predictive-staging-model-for-hiv-associated-kaposi-sarcoma-in-uganda
#4
Fred Okuku, Elizabeth M Krantz, James Kafeero, Moses R Kamya, Jackson Orem, Corey Casper, Warren Phipps
BACKGROUND: HIV-associated Kaposi sarcoma (KS) is commonly staged using the AIDS Clinical Trials Group criteria, which classify 3 variables-- tumor extent (T), immune status (I), and systemic symptoms (S) - into good risk (0) and poor risk (1). Although validated in the US and Europe, these criteria have not been systematically evaluated in sub-Saharan Africa (SSA), where the burden of KS is greatest. METHODS: We reviewed medical charts of adult patients with HIV-associated KS seen at the Uganda Cancer Institute from 1992-2007...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28060224/granulocytic-myeloid-derived-suppressor-cells-increased-in-early-phases-of-primary-hiv-infection-depending-on-trail-plasma-level
#5
N Tumino, M T Bilotta, C Pinnetti, A Ammassari, A Antinori, F Turchi, C Agrati, R Casetti, V Bordoni, E Cimini, I Abbate, M R Capobianchi, F Martini, A Sacchi
BACKGROUND: It has been demonstrated that Myeloid Derived Suppressor Cells (MDSC) are expanded in HIV-1 infected individuals and correlated with disease progression. The phase of HIV infection during which MDSC expansion occurs, and the mechanisms that regulate this expansion remain to be established. In this study we evaluated the frequency of MDSC in patients during primary HIV infection, and factors involved in MDSC control. METHODS: Patients with primary (PHI) and chronic (CHI) HIV infection were enrolled...
January 2, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28060226/barriers-to-care-and-1-year-mortality-among-newly-diagnosed-hiv-infected-people-in-durban-south-africa
#6
Ingrid V Bassett, Sharon M Coleman, Janet Giddy, MFamMed, Laura M Bogart, Christine E Chaisson, Douglas Ross, Moses J E Flash, Tessa Govender, Rochelle P Walensky, Kenneth A Freedberg, Elena Losina
BACKGROUND: Prompt entry into HIV care is often hindered by personal and structural barriers. Our objective was to evaluate the impact of self-perceived barriers to healthcare on 1-year mortality among newly diagnosed HIV-infected individuals in Durban, South Africa. METHODS: Prior to HIV testing at four outpatient sites, adults (≥18y) were surveyed regarding perceived barriers to care including: 1) service delivery; 2) financial; 3) personal health perception; 4) logistical; and 5) structural...
December 30, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28060225/association-between-menopause-and-unprotected-sex-in-high-risk-hiv-positive-women-in-mombasa-kenya
#7
Marielle S Goyette, Kate S Wilson, Ruth Deya, Linnet N Masese, Juma Shafi, Barbra A Richardson, Kishorchandra Mandaliya, Walter Jaoko, R Scott McClelland
OBJECTIVE: Many HIV-positive women now live well beyond menopause. Postmenopausal women are no longer at risk for pregnancy, and some studies suggest they may use condoms less often than premenopausal women. This study tests the hypothesis that, in HIV-positive women who report trading sex for cash or in-kind payment, unprotected sex is more common at postmenopausal visits compared to premenopausal visits. DESIGN: Prospective cohort study of HIV-positive women ≥16 years old in Mombasa, Kenya...
December 30, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28045766/baseline-vitamin-d-deficiency-decreases-the-effectiveness-of-statins-in-hiv-infected-adults-on-antiretroviral-therapy
#8
Corrilynn O Hileman, Vin Tangpricha, Abdus Sattar, Grace A McComsey
OBJECTIVE: Vitamin D deficiency is common in HIV. Statins may increase vitamin D and it is unknown whether vitamin D modifies the effect of statins on cardiovascular disease. DESIGN: SATURN-HIV was a 96-week, randomized, placebo-controlled trial designed to evaluate the effect of rosuvastatin on immune activation and subclinical vascular disease in HIV-infected adults on antiretroviral therapy. This analysis focuses on the pre-specified secondary endpoint 25-hydroxyvitamin D [25(OH)D] concentrations...
December 29, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28009639/increased-expression-of-the-type-i-interferon-receptor-on-cd4-t-lymphocytes-in-hiv-1-infected-individuals
#9
M Scott Killian, Sue H Fujimura, Ramu G Sudhagoni
BACKGROUND: Type I interferons (IFN1; e.g. IFN-α and IFN-β) are potent cytokines that inhibit the replication of human immunodeficiency virus-1 (HIV-1) and other viruses. The antiviral and immunoregulatory activities of IFN1 are mediated through ligand/receptor interactions with the IFN1 receptor complex (IFNAR). Variation in the cell surface density of IFNAR could play a role in HIV-1 pathogenesis. METHODS: In this cross-sectional study of fresh whole blood, we used flow cytometry to evaluate the expression of IFNAR2 on lymphocyte subsets from HIV-1-infected (n=33) and -uninfected (n=22) individuals...
December 22, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28002182/gender-differences-in-tobacco-use-among-persons-living-with-hiv-aids-a-systematic-review-and-meta-analysis
#10
Andrea H Weinberger, Philip H Smith, Allison P Funk, Shayna Rabin, Jonathan Shuter
BACKGROUND: Persons living with HIV/AIDS (PLWH) smoke at higher rates than other adults and experience HIV-related and non-HIV-related adverse smoking consequences. The current study conducted a systematic review to synthesize current knowledge about gender differences in smoking behaviors among PLWH. METHODS: Over three thousand abstracts from MEDLINE were reviewed and seventy-nine publications met all of the review inclusion criteria (i.e., reported data on smoking behaviors for PLWH by gender)...
December 20, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28002186/barriers-to-universal-prescribing-of-antiretroviral-therapy-by-hiv-care-providers-in-the-united-states-2013-2014
#11
John Weiser, John T Brooks, Jacek Skarbinski, Brady T West, Christopher C Duke, Garrett W Gremel, Linda Beer
INTRODUCTION: HIV treatment guidelines recommend initiating ART regardless of CD4 cell (CD4) count, barring contraindications or barriers to treatment. An estimated 6% of persons receiving HIV care in 2013 were not prescribed antiretroviral therapy (ART). We examined reasons for this gap in the care continuum. METHODS: During 2013-2014, we surveyed a probability sample of HIV care providers, of whom 1,234 returned surveys (64.0% adjusted response rate). We estimated percentages of providers who followed guidelines and their characteristics, and who deferred ART prescribing for any reason...
December 17, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28002185/field-evaluation-of-dried-blood-spots-for-hiv-1-viral-load-monitoring-in-adults-and-children-receiving-antiretroviral-treatment-in-kenya-implications-for-scale-up-in-resource-limited-settings
#12
Mary E Schmitz, Simon Agolory, Muthoni Junghae, Laura N Broyles, Muthusi Kimeu, Joseph Ombayo, Mamo Umuro, Irene Mukui, Kennedy Alwenya, Moses Baraza, Kenneth Ndiege, Samuel Mwalili, Emilia Rivadeneira, Lucy Ng'ang'a, Chunfu Yang, Clement Zeh
BACKGROUND: WHO recommends viral load (VL) as the preferred method for diagnosing antiretroviral therapy (ART) failure; however, operational challenges have hampered the implementation of VL monitoring in most resource-limited settings. This study evaluated the accuracy of dried blood spot (DBS) VL testing under field conditions as a practical alternative to plasma in determining virologic failure (VF). METHODS: From May to December 2013, paired plasma and DBS specimens were collected from 416 adults and 377 children on ART ≥6 months at 12 clinics in Kenya...
December 17, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28002184/prevalence-and-predictors-of-hospitalizations-among-hiv-infected-and-at-risk-hiv-uninfected-women
#13
Anna L Hotton, Kathleen M Weber, Ronald C Hershow, Kathryn Anastos, Peter Bacchetti, Elizabeth T Golub, Deborah Gustafson, Alexandra M Levine, Mary Young, Mardge H Cohen
OBJECTIVES: We evaluated the Veterans Aging Cohort Study (VACS) Index score, an index composed of age, CD4 count, viral load, hemoglobin, Hepatitis C (HCV) co-infection, Fibrosis Index-4 (FIB-4), and estimated glomerular filtration rate (EGFR), and psychosocial and clinical risk factors for all-cause hospitalization among HIV-infected women on HAART and HIV-uninfected women. METHODS: Data were collected from 2008 - 2014 from 1585 HAART-experienced HIV-infected and 692 uninfected women...
December 17, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28002183/relationship-between-time-to-initiation-of-antiretroviral-therapy-and-treatment-outcomes-a-cohort-analysis-of-art-eligible-adolescents-in-zimbabwe
#14
Florian Vogt, Andrea M Rehman, Katharina Kranzer, Mary Nyathi, Johan Van Griensven, Mark Dixon, Wedu Ndebele, Hilary Gunguwo, Robert Colebunders, Mbongeni Ndlovu, Tsitsi Apollo, Rashida A Ferrand
BACKGROUND: Age-specific retention challenges make ART initiation in adolescents difficult, often requiring a lengthy preparation process. This needs to be balanced against the benefits of starting treatment quickly. The optimal time to initiation duration in adolescents is currently unknown. OBJECTIVE: To assess the effect of time to ART initiation on mortality and loss to follow-up (LTFU) among treatment eligible adolescents. METHODS: We conducted a retrospective cohort analysis among 1,499 ART eligible adolescents aged ≥10 to <19 years registered in a public sector HIV programme in Bulawayo, Zimbabwe between 2004 and 2011...
December 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28045712/exploring-the-experiences-of-women-and-health-care-workers-in-the-context-of-pmtct-option-b-plus-in-malawi
#15
Fabian Cataldo, Levison Chiwaula, Misheck Nkhata, Monique van Lettow, Florence Kasende, Nora E Rosenberg, Hannock Tweya, Veena Sampathkumar, Mina Hosseinipour, Erik Schouten, Atupele Kapito-Tembo, Michael Eliya, Frank Chimbwandira, Sam Phiri
INTRODUCTION: Malawi has embarked on a 'test-and-treat' approach to prevent mother-to-child transmission of HIV (PMTCT), known as 'Option B+', offering all HIV-infected pregnant and breastfeeding women lifelong antiretroviral treatment (ART) regardless of CD4-count or clinical stage. We conducted a cross-sectional qualitative study to explore early experiences surrounding 'Option B+' for patients and health care workers (HCWs) in Malawi. METHODS: Study participants were purposively selected across six health facilities in three regional health zones in Malawi...
December 9, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27984559/psychiatric-symptoms-in-patients-receiving-dolutegravir
#16
Anna Fettiplace, Chris Stainsby, Alan Winston, Naomi Givens, Sarah Puccini, Vani Vannappagari, Ricky Hsu, Jennifer Fusco, Romina Quercia, Michael Aboud, Lloyd Curtis
INTRODUCTION: Psychiatric symptoms are reported to occur frequently in people living with HIV and may be associated with specific antiretrovirals. We analysed psychiatric symptoms observed with dolutegravir and other frequently prescribed anchor drugs. METHODS: Selected psychiatric symptoms (insomnia, anxiety, depression, and suicidality) occurring in HIV-positive patients during dolutegravir treatment across 5 randomized clinical trials (3 double-blind), in the Observational Pharmaco-Epidemiology Research & Analysis (OPERA®) cohort, and among cases spontaneously reported to ViiV Healthcare were analysed...
December 7, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27984558/the-impact-of-ledipasvir-sofosbuvir-on-hiv-positive-and-hiv-negative-japanese-hemophilia-patients-with-1-4-and-mixed-genotype-hcv
#17
Azusa Nagao, Hideji Hanabusa
INTRODUCTION: About 80% of patients with hemophilia who received non-heated coagulation factor concentrates in the early 1980s were infected with hepatitis C virus (HCV), and about 40% of them were infected with human immunodeficiency virus (HIV). AIM: We evaluated the efficacy and safety of administering ledipasvir (LDV)/sofosbuvir (SOF) to Japanese hemophilia patients. METHODS: Forty-three hemophilia patients with genotype 1 or 4 HCV were treated with LDV/SOF for 12 weeks...
December 7, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27984557/the-relationship-between-injection-drug-use-risk-behaviors-and-markers-of-immune-activation
#18
Sherry Deren, Charles M Cleland, Haekyung Lee, Saurabh Mehandru, Martin Markowitz
High levels of immune activation are reported for people who inject drugs (PWID). Studies of the relationship between injection behaviors and immune activation have yielded mixed results, in part due to lack of control for HCV in analyses. This study, of 48 HIV-seronegative PWID, examines this relationship controlling for HCV viremia. Frequency of injection was positively related to markers of immune activation (sCD14, %CD8+CD38+HLADR+T cells), as was duration of injection (hs-CRP and D-dimer). Sharing injection equipment was not related to markers studied...
December 7, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27984556/a-population-based-study-of-care-at-the-end-of-life-among-people-with-hiv-in-ontario-from-2010-to-2013
#19
Claire E Kendall, Mathieu Chalifoux, Doug Manuel, Robert Reinhard, Gregory Robinson, Jean Bacon, Sean B Rourke, Ron Rosenes, Peter Tanuseputro
BACKGROUND: Aging and increasing comorbidity is changing the end-of-life experience of people living with HIV (PLHIV) in the developed world. We quantified, at a population level, the receipt of health care services and associated costs across a comprehensive set of sectors among decedents with and without HIV. METHODS: We conducted a retrospective population-level observational study of all decedents in Ontario and their receipt of health care services, captured through linked health administrative databases, between April 1, 2010 and March 31, 2013...
December 7, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27984555/implementation-of-antiretroviral-therapy-for-life-in-pregnant-breastfeeding-hiv-women-option-b-alongside-rollout-and-changing-guidelines-for-art-initiation-in-rural-zimbabwe-the-lablite-project-experience
#20
Deborah Ford, Margaret Muzambi, Misheck J Nkhata, George Abongomera, Sarah Joseph, Makosonke Ndlovu, Travor Mabugu, Caroline Grundy, Adrienne K Chan, Fabian Cataldo, Cissy Kityo, Janet Seeley, Elly Katabira, Charles F Gilks, Andrew Reid, James Hakim, Diana M Gibb
BACKGROUND: Life-long ART for pregnant and breastfeeding women (Option B+) was rolled-out in Zimbabwe from 2014 with simultaneous raising of the CD4 treatment-threshold in non-pregnant/breastfeeding adults and children >5 years to 500 cells/mm. METHODS: Lablite is an implementation project in Zimbabwe, Malawi and Uganda evaluating ART rollout. Routine patient-level data were collected for 6 months prior to and 12 months after Option B+ rollout at a district hospital and three primary care facilities in Zimbabwe (two with outreach ART; one with no ART provision prior to Option B+)...
December 7, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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