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Journal of Acquired Immune Deficiency Syndromes: JAIDS

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https://www.readbyqxmd.com/read/29781885/improved-cognitive-performance-and-reduced-monocyte-activation-in-virally-suppressed-chronic-hiv-following-dual-ccr2-and-ccr5-antagonism
#1
Michelle L D'Antoni, Robert H Paul, Brooks I Mitchell, Lindsay Kohorn, Laurent Fischer, Eric Lefebvre, Star Seyedkazemi, Beau K Nakamoto, Maegen Walker, Kalpana J Kallianpur, Debra Ogata-Arakaki, Lishomwa C Ndhlovu, Cecilia Shikuma
OBJECTIVE: To evaluate changes in neuropsychological (NP) performance and in plasma and cell surface markers of peripheral monocyte activation/migration following treatment with cenicriviroc (CVC), a dual C-C chemokine receptor type 2 (CCR2) and type 5 (CCR5) antagonist, in treatment-experienced, HIV-infected individuals. SETTING: Single-arm, 24-week, open-label clinical trial. METHODS: HIV-infected individuals on antiretroviral therapy (ART) >1 year with plasma HIV RNA <50 copies/ml and below-normal cognitive performance [defined as age, gender and education-adjusted NP performance (NPZ) <-0...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781884/extended-release-naltrexone-improves-viral-suppression-levels-in-prisoners-with-hiv-and-alcohol-use-disorders-who-are-transitioning-to-the-community-results-from-a-double-blind-placebo-controlled-trial
#2
Sandra A Springer, Angela Di Paola, Russell Barbour, Marwan M Azar, Frederick L Altice
OBJECTIVE: To determine if extended-release naltrexone (XR-NTX) would improve or maintain viral suppression (VS) among incarcerated individuals with HIV and alcohol use disorders (AUDs) transitioning to the community. DESIGN: A randomized double-blind, placebo-controlled trial was conducted among incarcerated individuals with HIV and AUDs transitioning to the community from 2010 through 2016. METHODS: Eligible participants (N=100) were randomized 2:1 to receive 6 monthly injections of XR-NTX (n=67) or Placebo (n=33) starting at release and continued for 6 months...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781883/cytomegalovirus-specific-cd4-t-cell-responses-and-cmv-igg-levels-are-associated-with-neurocognitive-impairment-in-people-living-with-hiv
#3
Susanne Dam Nielsen, Vibe Ballegaard, Karin Kaereby Pedersen, Maria Pedersen, Peter Brændstrup, Nikolai Kirkby, Anette Stryhn Buus, Lars P Ryder, Jan Gerstoft
BACKGROUND: Mechanisms leading to neurocognitive impairment (NCI) in people living with HIV (PLWHIV) on stable antiretroviral therapy (cART) remain unknown. We investigated the association between CMV immunity, HIV-specific variables and NCI in PLWHIV on stable cART and with low comorbidity. METHODS: 52 PLWHIV on stable cART and 31 HIV-uninfected controls matched on age, gender, education and comorbidity were tested with a neurocognitive test-battery and CMV-immunoglobulin G (CMV-IgG) levels were measured...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781882/no-hiv-transmission-from-virally-suppressed-mothers-during-breastfeeding-in-rural-tanzania
#4
Ezekiel Luoga, Fiona Vanobberghen, Rahel Bircher, Amina Nyuri, Alex J Ntamatungiro, Dorcas Mnzava, Getrud J Mollel, Emilio Letang, Manuel Battegay, Maja Weisser, Anna Gamell
BACKGROUND: To what extent antiretroviral therapy (ART) reduces mother-to-child HIV transmission (MTCT) during breastfeeding remains unclear. We assessed the MTCT risk from mothers on ART to their infants during breastfeeding. SETTING: Ifakara, rural Tanzania. METHODS: We included infants born between 01/2013 and 05/2016 to mothers who initiated ART before delivery, had a negative HIV DNA-PCR at 4-12 weeks, and exclusively breastfed for ≥6 months...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781881/individual-and-network-factors-associated-with-hiv-care-continuum-outcomes-among-nigerian-msm-accessing-healthcare-services
#5
Habib O Ramadhani, Nicaise Ndembi, Rebecca G Nowak, Uchenna Ononaku, Jerry Gwamna, Ifeanyi Orazulike, Sylvia Adebajo, Trevor A Crowell, Hongjie Liu, Stefan D Baral, Julie Ake, Man E Charurat
BACKGROUND: and setting: As data on the determinants of the HIV care continuum from key populations such as men who have sex with men (MSM) in resource-limited, settings (RLS) are limited, the study aimed to characterize HIV care continuum outcomes and assess individual and network barriers to progression through the HIV care continuum among MSM in Abuja and Lagos, Nigeria. METHODS: TRUST/RV368 study used respondent-driven-sampling to accrue MSM into community-based clinics in Nigeria...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781880/willingness-to-donate-organs-among-people-living-with-hiv
#6
Anh Q Nguyen, Saad K Anjum, Samantha E Halpern, Komal Kumar, Sarah E Van Pilsum Rasmussen, Brianna Doby, Ashton A Shaffer, Allan B Massie, Aaron A R Tobian, Dorry L Segev, Jeremy Sugarman, Christine M Durand
BACKGROUND: With passage of the HIV Organ Policy Equity (HOPE) Act, people living with HIV (PLWH) can donate organs to PLWH awaiting transplant. Understanding knowledge and attitudes regarding organ donation among PLWH in the US is critical to implementing the HOPE Act. METHODS: PLWH were surveyed regarding their knowledge, attitudes, and beliefs about organ donation and transplantation at an urban academic HIV clinic in Baltimore, MD between 08/2016-10/2016. Responses were compared using Fisher's exact and chi-squared tests...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781879/cognitive-burden-of-common-non-antiretroviral-medications-in-hiv-infected-women
#7
Leah H Rubin, Kendra K Radtke, Seenae Eum, Bani Tamraz, Krithika N Kumanan, Gayle Springer, Pauline M Maki, Kathryn Anastos, Daniel Merenstein, Roksana Karim, Kathleen M Weber, Deborah Gustafson, Ruth M Greenblatt, Jeffrey R Bishop
OBJECTIVE: The aging HIV population has increased comorbidity burden and consequently non-antiretroviral (ARV) medication utilization. Many non-ARV medications have known neurocognitive-adverse effects ("NC-AE medications"). We assessed the cognitive effects of NC-AE medications in HIV+ and HIV- women. METHODS: 1558 participants (1037 HIV+; mean age 46) from the Women's Interagency HIV Study completed a neuropsychological test battery between 2009 and 2011...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781878/hiv-1-proviral-sequence-and-treatment-outcome-of-virologically-suppressed-patients-switching-to-coformulated-elvitegravir-cobicistat-emtricitabine-tenofovir-disoproxil-fumarate
#8
Kristen Andreatta, Silvia Chang, Ross Martin, Rima Kulkarni, Martin Daeumer, Alexander Thielen, Michael D Miller, Kirsten L White
No abstract text is available yet for this article.
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29781877/human-papillomavirus-genotypes-in-invasive-cervical-carcinoma-in-hiv-seropositive-and-seronegative-women-in-zimbabwe
#9
Washington Mudini, Joel Michael Palefsky, Martin John Hale, Michael Zvavahera Chirenje, Rudo Tanyaradzwa Makunike-Mutasa, Fiona Mutisi, Alltalents Murahwa, Altini Mario
BACKGROUND: Invasive cervical carcinoma (ICC) accounts for 23% of all cancer-related deaths in Zimbabwean women. Trials for a national program of genotype-specific HPV vaccines are underway to prevent cervical carcinoma, but the distribution of HPV types among women with ICC according to HIV status is unknown. METHODS: To determine prevalence and distribution of high-risk HPV genotypes by HIV status in women with ICC, we performed a cross-sectional study on women referred for ICC testing at four urban referral hospitals in Zimbabwe from June 2014 - December 2015...
May 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771782/differential-patterns-of-risk-and-vulnerability-suggest-the-need-for-novel-prevention-strategies-for-black-bisexual-men-in-the-hptn-061-study
#10
Typhanye V Dyer, Maria R Khan, Rotrease Regan, Nina T Harawa, LaRon E Nelson, Leo Wilton, Lei Wang, Lili Peng, San San Ou, Steve Shoptaw
BACKGROUND: Black men who have sex with men (BMSM); some who also have sex with women (BMSMW), account for over 70% of new HIV infections in the US representing an elevated HIV risk in this group, also informing risks for HIV transmission to other BMSM and female sexual partners. SETTINGS: We examined trajectories of self-reported substance use, HIV-related sexual risk behaviors and psychosocial vulnerabilities among BMSMW versus BMSM over a one-year study period...
May 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771779/cost-of-integrating-non-communicable-disease-screening-into-home-based-hiv-testing-and-counseling-in-south-africa
#11
Ilya Golovaty, Monisha Sharma, Alastair Van Heerden, Heidi van Rooyen, Jared M Baeten, Connie Celum, Ruanne V Barnabas
INTRODUCTION: Integrated HIV-non-communicable disease (NCD) services have the potential to avert death and disability, but require data on program costs to assess the impact of integrated services on affordability. METHODS: We estimated the incremental costs of NCD screening as part of home-based HIV testing and counseling (HTC) and referral to care in KwaZulu-Natal, South Africa. All adults in the households were offered integrated HIV-NCD screening (for HIV, diabetes, hypertension, hypercholesterolemia, obesity, depression, tobacco and alcohol use), counseling, and linkage to care...
May 10, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29757775/development-and-calibration-of-a-mathematical-model-of-anal-carcinogenesis-for-high-risk-hiv-infected-men
#12
Emily A Burger, Michael A Dyer, Stephen Sy, Joel M Palefsky, Alexandra De Pokomandy, François Coutlee, Michael J Silverberg, Jane J Kim
OBJECTIVES: Men who have sex with men (MSM) who are living with human immunodeficiency virus (HIV) are at highest risk for anal cancer. Our objective was to use empirical data to develop a comprehensive disease simulation model that reflects the most current understanding of anal carcinogenesis, which is uniquely positioned to evaluate future anal cancer screening strategies as well as provide insight on the unobservable course of the disease. SETTING: North America METHODS...
May 9, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771794/hiv-risk-reduction-by-avoiding-sex-with-partners-unwilling-to-undergo-hiv-testing-is-not-coercion
#13
Iván C Balán, Timothy Frasca, Curtis Dolezal, Alex Carballo-Diéguez
No abstract text is available yet for this article.
May 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771793/the-association-of-chronic-pain-and-long-term-opioid-therapy-with-hiv-treatment-outcomes
#14
Jessica S Merlin, Dustin Long, William C Becker, Edward R Cachay, Katerina A Christopolous, Kasey Claborn, Heidi M Crane, E Jennifer Edelman, Richard Harding, Stefan G Kertesz, Jane M Liebschutz, W Christopher Mathews, Michael J Mugavero, Sonia Napravnik, Connall O'Cleirigh, Michael S Saag, Joanna L Starrels, Robert Gross
BACKGROUND: Chronic pain occurs in up to 85% of persons living with HIV (PLWH) and is commonly treated with long-term opioid therapy (LTOT). We investigated the impact of chronic pain and LTOT on HIV outcomes. METHODS: This was prospective cohort study conducted between 7/2015-7/2016 in five HIV primary care clinics. Chronic pain was defined as ≥moderate pain for ≥3 months on the Brief Chronic Pain Questionnaire and ≥4/10 on the Pain Enjoyment of life and General activity (PEG) questionnaire...
May 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771792/using-a-social-network-strategy-to-distribute-hiv-self-test-kits-to-african-american-and-latino-msm
#15
Marguerita A Lightfoot, Chadwick K Campbell, Nicholas Moss, Sarah Treves-Kagan, Emily Agnew, Mi-Suk Kang Dufour, Hyman Scott, Aria M Sa'id, Sheri A Lippman
BACKGROUND: Men who have sex with men (MSM) continue to be disproportionately impacted globally by the HIV epidemic. Studies suggest that HIV Self-testing (HIVST) is highly acceptable among MSM. Social network strategies to increase testing are effective in reaching MSM, particularly MSM of color, who may not otherwise test. We tested a social-network based strategy to distribute HIVST kits to African American and Latino MSM. SETTING: This study was conducted in Alameda County, California a large, urban/suburban county with an HIV epidemic mirroring the national HIV epidemic...
May 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771790/patterns-and-correlates-of-participant-retention-in-a-multi-city-pre-exposure-prophylaxis-demonstration-project
#16
Susanne Doblecki-Lewis, Albert Y Liu, Daniel J Feaster, Stephanie E Cohen, Richard Elion, Oliver Bacon, Megan Coleman, Gabriel Cardenas, Michael A Kolber
BACKGROUND: Safe and effective use of pre-exposure prophylaxis (PrEP) depends on retention in care after initial engagement. SETTING: The United States PrEP Demonstration Project offered daily oral tenofovir/emtricitabine to participants in San Francisco, Miami, and Washington, D.C. for 48 weeks from 2012-2014. METHODS: Demo Project participants' patterns of retention were assigned to one of three categories: early loss to follow-up (ELTF) within the first 12 weeks of the study, retention throughout the study, or intermittent retention in which missed or delayed visits resulted in gaps in medication availability...
May 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771789/raltegravir-1200-mg-once-daily-vs-400-mg-twice-daily-with-emtricitabine-and-tenofovir-disoproxil-fumarate-for-previously-untreated-hiv-1-infection-week-96-results-from-oncemrk-a-randomized-double-blind-non-inferiority-trial
#17
Pedro Cahn, Paul E Sax, Kathleen Squires, Jean-Michel Molina, Winai Ratanasuwan, Mohammed Rassool, Mark Bloch, Xia Xu, Yan Zhou, Brenda Homony, Deborah Hepler, Hedy Teppler, George J Hanna, Bach-Yen Nguyen, Wayne Greaves
BACKGROUND: Raltegravir 1200mg (2x600mg tablets) once daily (QD) demonstrated non-inferior efficacy and similar safety to raltegravir 400mg BID at Week 48 of the ONCEMRK trial. Here we report the Week 96 results from this study. METHODS: ONCEMRK is a phase 3, multicenter, double-blind, non-inferiority trial comparing raltegravir 1200mg QD to raltegravir 400mg BID in treatment-naïve HIV-1-infected adults. Participants were assigned (2:1) to raltegravir 2x600mg QD or 400mg BID, both with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) for 96 weeks...
May 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771788/body-mass-index-and-the-risk-of-serious-non-aids-events-and-all-cause-mortality-in-treated-hiv-positive-individuals-d-a-d-cohort-analysis
#18
Amit C Achhra, Caroline Sabin, Lene Ryom, Camilla Hatleberg, Antonella d'Aminio Monforte, Stephane de Wit, Andrew Phillips, Christian Pradier, Rainer Weber, Peter Reiss, Wafaa El-Sadr, Fabrice Bonnet, Amanda Mocroft, Jens Lundgren, Matthew G Law
BACKGROUND: The relationship between body mass index (BMI) (weight (kg)/ height(m)) and serious non-AIDS events is not well understood. METHODS: We followed D:A:D study participants on antiretroviral therapy from their first BMI measurement to the first occurrence of the endpoint or end of follow-up (N=41,149 followed for 295,147 person-years). The endpoints were cardiovascular disease (CVD); diabetes; non-AIDS-defining cancers (NADCs) and BMI-NADCs (cancers known to be associated with BMI in general population); and all-cause mortality...
May 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771791/a-successful-model-of-expedited-antiretroviral-therapy-for-clinically-stable-patients-living-with-hiv-in-haiti
#19
Colette Guiteau Moise, Vanessa R Rivera, Kelly A Hennessey, Clovy Bellot, Chris Nicholas, Anna P Fang, Rose Irène Verdier, Patrice Severe, Alix Sainvil, Benedict Charles, Derothy Dorval, Juseline St Amour, Jean W Pape, Serena P Koenig
BACKGROUND: Recommendations for universal antiretroviral therapy (ART) have greatly increased the number of HIV-infected patients who qualify for treatment, particularly with early clinical disease. Less intensive models of care are needed for clinically stable patients. SETTING: A Rapid Pathway (RP) model of expedited outpatient care for clinically stable patients was implemented at the Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO) Center, Port-au-Prince, Haiti...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771787/point-of-care-cryptococcal-antigen-screening-pipetting-finger-prick-blood-improves-performance-of-immuno-mycologics-lateral-flow-assay
#20
Rachel M Wake, Joseph N Jarvis, Thomas S Harrison, Nelesh P Govender
BACKGROUND: Cryptococcal antigen (CrAg) screening at point of care could improve cryptococcal meningitis prevention where laboratory resources are limited. We evaluated the accuracy of Immuno-Mycologics (IMMY, Norman, OK) CrAg lateral flow assay (LFA) using different techniques at point of care. SETTING: Two tertiary-level hospitals in Johannesburg and a community health clinic in Soweto, South Africa. METHODS: A case-control diagnostic validation study, and a prospective clinic-based implementation study using the IMMY CrAg LFA on finger-prick blood...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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