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Journal of Acquired Immune Deficiency Syndromes: JAIDS

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https://www.readbyqxmd.com/read/28930769/acute-alcohol-consumption-directly-increases-hiv-transmission-risk-a-randomized-controlled-experiment
#1
Paul A Shuper, Narges Joharchi, Peter M Monti, Mona Loutfy, Jürgen Rehm
BACKGROUND: Alcohol consumption has frequently been purported as a driver of condomless sex and HIV transmission, but to date, experimental evidence for the causal risk-taking impact of alcohol among HIV-positive populations is lacking. The present experiment sought to determine whether acute alcohol consumption has a direct causal impact on condomless sex intentions among HIV-positive men-who-have-sex-with-men (MSM), and to assess whether alcohol's impact differs between MSM who are HIV-positive versus HIV-negative...
September 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902706/cognitive-impairment-in-a-clinical-setting
#2
Francesca Ferretti, Borja Mora-Peris, Jonathan Underwood, Adam Waldman, Alex Everitt, Alan Winston
No abstract text is available yet for this article.
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902705/effects-of-vitamin-d-supplementation-on-bone-mineral-density-and-bone-markers-in-hiv-infected-youth
#3
Allison Ross Eckard, Mary Ann O'Riordan, Julia C Rosebush, Joshua H Ruff, Ann Chahroudi, Danielle Labbato, Julie E Daniels, Monika Uribe-Leitz, Vin Tangpricha, Grace A McComsey
BACKGROUND: Low bone mineral density (BMD) is a significant co-morbidity in HIV. However, studies evaluating vitamin D supplementation on bone health in this population are limited. This study investigates changes in bone health parameters after 12 months of supplementation in HIV-infected youth with vitamin D insufficiency. METHODS: This is a randomized, active-control, double-blind trial investigating changes in bone parameters with 3 different vitamin D3 doses [18,000 (standard/control dose), 60,000 (moderate dose) and 120,000 IU/monthly (high dose)] in HIV-infected youth 8-25 years old with baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations <30 ng/mL...
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902704/hiv-pre-exposure-prophylaxis-implementation-at-local-health-departments-a-statewide-assessment-of-activities-and-barriers
#4
Helen L Zhang, Sarah K Rhea, Christopher B Hurt, Victoria L Mobley, Heidi Swygard, Arlene C Seña, Mehri S McKellar
BACKGROUND: Expanding access to HIV pre-exposure prophylaxis (PrEP) could help reduce rates of HIV infection in the United States. This study characterizes activities and barriers to PrEP implementation at local health departments (LHDs) in North Carolina (NC), which contains a large rural population. METHODS: In May 2016, a web-based survey was distributed to health directors of all county and district health departments in NC to assess PrEP-related activities, perceived barriers to PrEP implementation, and desired PrEP-related resources...
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902703/the-effect-of-schooling-on-age-disparate-relationships-and-number-of-sexual-partners-among-young-women-in-rural-south-africa-enrolled-in-hptn-068
#5
Marie C D Stoner, Jessie K Edwards, William C Miller, Allison E Aiello, Carolyn T Halpern, Aimée Julien, Amanda Selin, James P Hughes, Jing Wang, F Xavier Gomez-Olive, Ryan G Wagner, Catherine MacPhail, Kathleen Kahn, Audrey Pettifor
BACKGROUND: Attending school may have a strong preventative association with sexually transmitted infections among young women, but the mechanism for this relationship is unknown. One hypothesis is that students who attend school practice safer sex with fewer partners, establishing safer sexual networks that make them less exposed to infection. SETTING: We used longitudinal data from a randomized controlled trial of young women age 13-20 in the Bushbuckridge district, South Africa, to determine if the percentage of school days attended, school dropout and grade repetition are associated with having a partner five or more years older (age-disparate) and with the number of sexual partners in the previous 12 months...
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28914669/infection-staging-and-incidence-surveillance-applications-of-high-dynamic-range-diagnostic-immuno-assay-platforms
#6
Eduard Grebe, Alex Welte, Jake Hall, Sheila M Keating, Shelley N Facente, Kara Marson, Jeffrey N Martin, Susan J Little, Matthew A Price, Esper G Kallas, Michael P Busch, Christopher D Pilcher, Gary Murphy
BACKGROUND: Custom HIV staging assays, including the Sedia™ HIV-1 Limiting Antigen Avidity EIA (LAg) and avidity modifications of the Ortho VITROS® anti-HIV-1+2 and Abbott ARCHITECT HIV Ag/Ab Combo assays, are used to identify 'recent' infections in clinical settings and for cross-sectional HIV incidence estimation. However, the high dynamic range of chemiluminescent platforms allows differentiating recent and longstanding infection on signal intensity, and this raises the prospect of using unmodified diagnostic assays for infection timing and surveillance applications...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902074/plasma-tenofovir-levels-to-support-adherence-to-tdf-ftc-pre-exposure-prophylaxis-for-hiv-prevention-in-msm-in-los-angeles-california
#7
Raphael J Landovitz, Matthew Beymer, Ryan Kofron, K Rivet Amico, Christina Psaros, Lane Bushman, Peter L Anderson, Risa Flynn, David P Lee, Robert K Bolan, Wilbert C Jordan, Chi-Hong Tseng, Rhodri Dierst-Davies, Jim Rooney, Amy Rock Wohl
BACKGROUND: TDF/FTC PrEP is effective against rectal HIV acquisition when taken as prescribed. Strategies that identify and intervene with those challenged by adherence to daily medication are needed. SETTING: PATH-PrEP was an open-label single arm interventional cohort study conducted at 2 community-based clinical sites in Los Angeles, California. METHODS: We enrolled self-identified MSM and TGW ≥18 years of age at elevated risk of HIV acquisition...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902073/cryotherapy-reduces-progression-of-cervical-intraepithelial-neoplasia-grade-1-in-south-african-hiv-infected-women-a-randomized-controlled-trial
#8
Cynthia Firnhaber, Avril Swarts, Bridgette Goeieman, Ntombi Rakhombe, Masangu Mulongo, Anna-Lise Williamson, Pam Michelow, Sibongile Ramotshela, Mark Faesen, Simon Levin, Timothy Wilkin
BACKGROUND: HIV-infected women are at increased risk of cervical cancer, especially in resource-limited countries. Cervical cancer prevention strategies focus treating cervical high-grade squamous intraepithelial lesions (HSIL). The management of low-grade squamous intraepithelial lesions (LSIL) in HIV-infected women is unknown. SETTING: HIV treatment clinic in Johannesburg, South Africa METHODS:: We randomized HIV-infected women with histologic cervical LSIL to cervical cryotherapy vs...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902072/hiv-transmission-dynamics-among-foreign-born-persons-in-the-united-states
#9
Eduardo E Valverde, Alexandra M Oster, Songli Xu, Joel O Wertheim, Angela L Hernandez
BACKGROUND: In the United States (U.S.), foreign-born persons are disproportionately affected by HIV and differ epidemiologically from U.S.-born persons with diagnosed HIV infection. Understanding HIV transmission dynamics among foreign-born persons is important to guide HIV prevention efforts for these populations. We conducted molecular transmission network analysis to describe HIV transmission dynamics among foreign-born persons with diagnosed HIV. METHODS: Using HIV-1 polymerase nucleotide sequences reported to the U...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28902071/the-importance-of-risk-perception-predictors-of-prep-acceptance-among-thai-msm-and-tg-women-at-a-community-based-health-service
#10
Rosalyn Plotzker, Pich Seekaew, Jureeporn Jantarapakde, Supabhorn Pengnonyang, Deondara Trachunthong, Danai Lingjongrat, Surang Janyam, Thitiyanun Nakpor, Sutinee Charoenying, Stephen Mills, Ravipa Vannakit, Michael Cassell, Praphan Phanuphak, Cheewanan Lertpiriyasuwat, Nittaya Phanuphak
BACKGROUND: HIV prevalence among Thai men who have sex with men (MSM) and transgender women (TG) are 9.15% and 11.8% respectively, compared to 1.1% in the general population. To better understand early adopters of Pre-Exposure Prophylaxis (PrEP) in Thailand, we analyzed bio-behavioral and socio-demographic characteristics of PrEP-eligible MSM and TG. SETTING: Four Thai urban community clinics between October 2015 and February 2016 METHODS:: Socio-demographics, HIV risk characteristics, and PrEP knowledge and attitudes, were analyzed in association with PrEP initiation among eligible Thai MSM and TG...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28885271/isoniazid-preventive-therapy-completion-in-the-era-of-differentiated-hiv-care
#11
Khai Hoan Tram, Florence Mwangwa, Mucunguzi Atukunda, Asiphas Owaraganise, James Ayieko, Albert Plenty, Dalsone Kwariisima, Tamara D Clark, Moses R Kamya, Maya L Petersen, Edwin D Charlebois, Gabriel Chamie, Diane V Havlir, Carina Marquez
No abstract text is available yet for this article.
September 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28885270/association-between-internalized-hiv-related-stigma-and-hiv-care-visit-adherence
#12
Whitney S Rice, Kaylee Burnham, Michael J Mugavero, James L Raper, Ghislaine C Atkins, Bulent Turan
BACKGROUND: Internalized HIV-related stigma acts as a barrier to antiretroviral therapy (ART) adherence, but its effects on other HIV care continuum outcomes is unclear. METHODS: Among 196 HIV clinic patients in Birmingham, Alabama, we assessed internalized HIV-related stigma and depressive symptom severity using validated multi-item scales, and assessed ART adherence using a validated single-item measure. HIV visit adherence (attended out of total scheduled visits) was calculated using data from clinic records...
September 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28885269/increasing-hiv-treatment-optimism-but-no-changes-in-hiv-risk-behaviour-among-men-who-have-sex-with-men-msm-in-vancouver-canada
#13
David M Moore, Zishan Cui, Nathan J Lachowsky, Ashleigh J Rich, Eric A Roth, Henry Fisher Raymond, Paul Sereda, Julio Montaner, Jason Wong, Heather L Armstrong, David Hall, Robert S Hogg
No abstract text is available yet for this article.
September 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28857937/newly-acquired-infection-with-multi-drug-resistant-hiv-1-in-a-patient-adherent-to-pre-exposure-prophylaxis
#14
Martin Markowitz, Howard Grossman, Peter L Anderson, Robert Grant, Monica Gandhi, Howard Horng, Hiroshi Mohri
No abstract text is available yet for this article.
August 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28857936/radiofrequency-ablation-therapy-for-anal-intraepithelial-neoplasia-results-from-a-single-center-prospective-pilot-study-in-hiv-participants
#15
Robert N Goldstone, Shirin R Hasan, Stephen E Goldstone
BACKGROUND: HIV-positive individuals have high incidence of anal high-grade squamous intraepithelial lesions (HSIL) at the squamocolumnar junction (SCJ), which can progress to cancer.1 Focal radiofrequency ablation (RFA) treats HSIL, but metachronous recurrence remains high and may be improved with circumferential treatment. SETTING: The study was performed at a single center. METHODS: This was a prospective trial of circumferential anal RFA using Barrx™ 60 RFA focal catheters in participants with ≥1 anal SCJ HSIL...
August 26, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28834799/stigma-and-hiv-care-continuum-outcomes-among-ethiopian-adults-initiating-art
#16
Susie Hoffman, Olga Tymejczyk, Sarah Kulkarni, Maria Lahuerta, Tsigereda Gadisa, Robert H Remien, Zenebe Melaku, Denis Nash, Batya Elul
BACKGROUND: Stigma harms the mental health of HIV-positive individuals and reduces adherence to antiretroviral therapy (ART), but less is known about stigma and other outcomes across the HIV care continuum. METHODS: Among 1180 Ethiopian adults initiating ART at six urban HIV clinics, we examined the relationship of internalized, anticipated, and enacted stigma to HIV care-related outcomes ascertained by interview (repeat HIV-positive testing, provider vs. self-referred testing, missed clinic visit before ART initiation, eagerness to begin ART) and by abstraction of routinely collected clinical data (late ART initiation, 3-month gap in care following ART initiation)...
August 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28834798/estimated-coverage-to-address-financial-barriers-to-hiv-preexposure-prophylaxis-among-persons-with-indications-for-its-use-united-states-2015
#17
Dawn K Smith, Michelle Van Handel, Rebecca Huggins
BACKGROUND: An estimated 1.2 million American adults engage in sexual and drug use behaviors that place them at significant risk of acquiring HIV infection. Engagement in health care for the provision of daily oral antiretroviral medication as preexposure prophylaxis (PrEP), when clinically indicated, could substantially reduce the number of new HIV infections in these persons. However, resources to cover the financial cost of PrEP care is an anticipated barrier for many of the populations with high numbers of new HIV infections...
August 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28825944/brief-report-lopinavir-hair-concentrations-are-the-strongest-predictor-of-viremia-in-hiv-infected-asian-children-and-adolescents-on-second-line-antiretroviral-therapy
#18
Jillian Pintye, Peter Bacchetti, Sirinya Teeraananchai, Stephen Kerr, Wasana Prasitsuebsai, Thida Singtoroj, Karen Kuncze, Alexander Louie, Catherine A Koss, Chengshi Jin, Nhi Phung, Howard Horng, Annette H Sohn, Monica Gandhi
BACKGROUND: Children/adolescents display suboptimal antiretroviral therapy (ART) adherence and outcomes versus adults. Hair ART concentrations are objective adherence measures that predict viremia in adults but longitudinal data on hair levels in pediatric populations is limited. We assessed the predictive utility of hair lopinavir levels on viremia among youth on second-line ART. METHODS: We examined predictors of viremia (HIV-1 RNA >400 and >1000 copies/ml) at least 24 weeks after switch to lopinavir-based second-line ART in a cohort of HIV-infected Asian children followed between 2011 and 2014...
August 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28825943/weight-gain-in-persons-with-hiv-switched-from-efavirenz-based-to-integrase-strand-transfer-inhibitor-based-regimens
#19
Jamison Norwood, Megan Turner, Carmen Bofill, Peter Rebeiro, Bryan Shepherd, Sally Bebawy, Todd Hulgan, Stephen Raffanti, David W Haas, Timothy R Sterling, John R Koethe
BACKGROUND: With the introduction of integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART), persons living with HIV have a potent new treatment option. Recently, providers at our large treatment clinic noted weight gain in several patients switched from efavirenz/tenofovir disoproxil fumarate/emtricitabine (EFV/TDF/FTC) to dolutegravir/abacavir/lamivudine (DTG/ABC/3TC). In this study, we evaluated weight change in patients with sustained virologic suppression switched from EFV/TDF/FTC to an INSTI-containing regimen...
August 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28825942/inflammatory-colonic-innate-lymphoid-cells-are-increased-during-untreated-hiv-1-infection-and-associated-with-markers-of-gut-dysbiosis-and-mucosal-immune-activation
#20
Stephanie M Dillon, Moriah J Castleman, Daniel N Frank, Gregory L Austin, Sara Gianella, Andrew C Cogswell, Alan L Landay, Edward Barker, Cara C Wilson
BACKGROUND: HIV-1 infection is associated with intestinal inflammation, changes in the enteric microbiota (dysbiosis) and intestinal epithelial cell (IEC) damage. NKp44 innate lymphoid cells (ILCs) play an important role in epithelial barrier maintenance via the production of IL-22, but also display functional plasticity and can produce inflammatory cytokines (e.g. IFNg) in response to cytokine milieu and stimulatory signals. The objective of this pilot study was to enumerate frequencies of IL-22 and IFNg-expressing colonic NKp44 ILCs during untreated, chronic HIV-1 infection...
August 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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