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Investigative Radiology

Markus M Obmann, Vanessa Kelsch, Aurelio Cosentino, Verena Hofmann, Daniel T Boll, Matthias R Benz
OBJECTIVE: The aim of the current study was to evaluate the reliability and comparability of virtual unenhanced (VUE) attenuation values derived from scans of a single-source, dual-energy computed tomography using a split-filter (tbDECT) to a dual-source dual-energy CT (dsDECT). MATERIALS AND METHODS: In this retrospective study, comparisons for tbDECT and dsDECT were made within and between different dual-energy platforms. For the interscanner comparison, 126 patients were scanned with both scanners within a time interval of 224 ± 180 days; for the intrascanner comparison, another 90 patients were scanned twice with the same scanner within a time interval of 136 ± 140 days...
August 9, 2018: Investigative Radiology
Nora N Sommer, Karla M Treitl, Eva Coppenrath, Hendrik Kooijman, Claudia Dechant, Michael Czihal, Theresa M Kolben, Sebastian E Beyer, Wieland H Sommer, Tobias Saam
OBJECTIVES: Arteritic anterior ischemic optic neuropathy (A-AION) caused by inflammatory occlusion of the posterior ciliary arteries is the most common reason for irreversible vision loss in patients with giant cell arteritis. Atypical clinical presentation and negative funduscopy can delay systemic high-dose corticosteroid therapy to prevent impending permanent blindness and involvement of the contralateral eye.The purpose of this study was to assess the diagnostic accuracy of 3-dimensional (3D) high-resolution T1-weighted black-blood magnetic resonance imaging (T1-BB-MRI) for the detection of posterior ciliary artery involvement in patients with giant cell arteritis and funduscopic A-AION...
August 8, 2018: Investigative Radiology
Filippo Del Grande, Marco Delcogliano, Riccardo Guglielmi, Esther Raithel, Steven E Stern, Derek F Papp, Christian Candrian, Jan Fritz
OBJECTIVES: The aim of this study was to test the hypothesis that magnetic resonance imaging (MRI) of the knee with 10-minute 3-dimensional (3D) controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) sampling perfection with application optimized contrast using different flip angle evolutions (SPACE) turbo spin echo (TSE) protocols can replace 20-minute 2-dimensional (2D) TSE standard-of-reference protocols for the diagnosis of internal derangement. MATERIALS AND METHODS: After internal review board approval and prospective informed consent, 100 symptomatic subjects underwent MRI of the knee at 3 T and 50 symptomatic subjects at 1...
August 6, 2018: Investigative Radiology
Youngjune Kim, Kyong Joon Lee, Leonard Sunwoo, Dongjun Choi, Chang-Mo Nam, Jungheum Cho, Jihyun Kim, Yun Jung Bae, Roh-Eul Yoo, Byung Se Choi, Cheolkyu Jung, Jae Hyoung Kim
OBJECTIVES: The aim of this study was to compare the diagnostic performance of a deep learning algorithm with that of radiologists in diagnosing maxillary sinusitis on Waters' view radiographs. MATERIALS AND METHODS: Among 80,475 Waters' view radiographs, examined between May 2003 and February 2017, 9000 randomly selected cases were classified as normal or maxillary sinusitis based on radiographic findings and divided into training (n = 8000) and validation (n = 1000) sets to develop a deep learning algorithm...
July 31, 2018: Investigative Radiology
Guillaume P O Marie, Polona Pozeg, Reto A Meuli, Philippe Maeder, Joachim Forget
OBJECTIVES: The purpose of the study was to systematically evaluate the precise spatial and temporal pattern of gadolinium-related changes in T1-weighted signal intensity on unenhanced magnetic resonance (MR) images, occurring in the deep brain nuclei of adult patients exposed to at least 10 consecutive doses of gadodiamide. MATERIALS AND METHODS: In this monocentric retrospective longitudinal study, we analyzed the brain MR images of 30 patients (12 women, 18 men; mean age, 43 ± 11...
July 20, 2018: Investigative Radiology
Mikell Yuhasz, Michael J Hoch, Mari Hagiwara, Mary T Bruno, James S Babb, Esther Raithel, Christoph Forman, Abbas Anwar, J Thomas Roland, Timothy M Shepherd
BACKGROUND AND PURPOSE: High-resolution T2-weighted sequences are frequently used in magnetic resonance imaging (MRI) studies to assess the cerebellopontine angle and internal auditory canal (IAC) in sensorineural hearing loss patients but have low yield and lengthened examinations. Because image content in the Wavelet domain is sparse, compressed sensing (CS) that uses incoherent undersampling of k-space and iterative reconstruction can accelerate MRI acquisitions. We hypothesized that an accelerated CS T2 Sampling Perfection with Application optimized Contrasts using different flip angle Evolution (SPACE) sequence would produce acceptable diagnostic quality for IAC screening protocols...
July 16, 2018: Investigative Radiology
Iman Khodarahmi, Reham R Haroun, Moses Lee, George S K Fung, Matthew K Fuld, Lew C Schon, Elliot K Fishman, Jan Fritz
OBJECTIVE: The aim of this study was to compare the effects of combined virtual monoenergetic extrapolation (VME) of dual-energy computed tomography data and iterative metal artifact reduction (iMAR) at higher photon energies on low- and high-density metal artifacts and overall image quality of the ankle arthroplasty implants with iMAR, weighted filtered back projection (WFBP), and WFBP-based VME. MATERIALS AND METHODS: Total ankle arthroplasty implants in 6 human cadaver ankles served as surrogates for arthroplasty implants...
July 14, 2018: Investigative Radiology
Robyn Melanie Benz, Dorothee Harder, Felix Amsler, Johannes Voigt, Andreas Fieselmann, Anna Lucja Falkowski, Bram Stieltjes, Anna Hirschmann
OBJECTIVES: The aims of this study were to assess feasibility, image quality, and radiation dose and to estimate the optimal dose protocol for the lumbar spine of cadaveric specimens with different body mass indices (BMIs) in the upright position using a prototype 3-dimensional cone-beam computed tomography (CT) software implemented on a robotic x-ray system and compare with CT. MATERIALS AND METHODS: The lumbar spine of 5 formalin-fixed human cadaveric specimens (BMI, 22-35 kg/m) was prospectively assessed in the upright position using prototype software for 3-dimensional tomography implemented on a robotic x-ray system...
July 12, 2018: Investigative Radiology
Stephan H Polanec, Thomas H Helbich, Hubert Bickel, Georg J Wengert, Katja Pinker, Claudio Spick, Paola Clauser, Martin Susani, Shahrokh Shariat, Pascal A T Baltzer
OBJECTIVE: The aim of this study was to evaluate the potential of diffusion-weighted imaging-derived apparent diffusion coefficient (ADC) measurements to obviate unnecessary biopsies in multiparametric MRI-detected PI-RADS 4 and 5 lesions. MATERIALS AND METHODS: This retrospective, institutional review board-approved study investigated 101 PI-RADS 4 and 5 prostate lesions (52 malignant, 49 benign) verified by in-bore MRI-guided biopsy in 101 men (mean age, 62.8 years)...
July 6, 2018: Investigative Radiology
Annina B Schmid, Jon Campbell, Samuel A Hurley, Saad Jbabdi, Jesper L Andersson, Mark Jenkinson, Neal K Bangerter, David L Bennett, Irene Tracey, Robert Frost, Stuart Clare
OBJECTIVES: The aim of this study was to describe the development of morphologic and diffusion tensor imaging sequences of peripheral nerves at 7 T, using carpal tunnel syndrome (CTS) as a model system of focal nerve injury. MATERIALS AND METHODS: Morphologic images were acquired at 7 T using a balanced steady-state free precession sequence. Diffusion tensor imaging was performed using single-shot echo-planar imaging and readout-segmented echo-planar imaging sequences...
July 3, 2018: Investigative Radiology
Jan C M van Zelst, Suzan Vreemann, Hans-Joerg Witt, Albert Gubern-Merida, Monique D Dorrius, Katya Duvivier, Susanne Lardenoije-Broker, Marc B I Lobbes, Claudette Loo, Wouter Veldhuis, Jeroen Veltman, Daniel Drieling, Nico Karssemeijer, Ritse M Mann
OBJECTIVES: Breast cancer screening using magnetic resonance imaging (MRI) has limited accessibility due to high costs of breast MRI. Ultrafast dynamic contrast-enhanced breast MRI can be acquired within 2 minutes. We aimed to assess whether screening performance of breast radiologist using an ultrafast breast MRI-only screening protocol is as good as performance using a full multiparametric diagnostic MRI protocol (FDP). MATERIALS AND METHODS: The institutional review board approved this study, and waived the need for informed consent...
June 25, 2018: Investigative Radiology
Keitaro Sofue, Toshihide Itoh, Satoru Takahashi, Bernhard Schmidt, Ryuji Shimada, Noriyuki Negi, Kazuro Sugimura, Takamichi Murakami
OBJECTIVE: The aim of this study was to assess the ability of third-generation dual-source dual-energy computed tomography to quantify cisplatin concentration using a 3-material decomposition algorithm in an experimental phantom. MATERIALS AND METHODS: Fifteen agarose-based phantoms containing various concentrations of iodine (0, 1.0, 2.0 mg I/mL) and cisplatin (0, 0.5, 1.0, 2.0, 3.0 mg Pt/mL) were scanned using third-generation dual-source dual-energy computed tomography at 80 kV and 150 kV with tin prefiltration...
June 14, 2018: Investigative Radiology
Jana Taron, Jakob Weiss, Mike Notohamiprodjo, Thomas Kuestner, Fabian Bamberg, Elisabeth Weiland, Bernd Kuehn, Petros Martirosian
OBJECTIVES: Magnetic resonance cholangiopancreatography (MRCP) is an established technique in routine magnetic resonance examination. By applying the compressed sensing (CS) acceleration technique to conventional MRCP sequences, scan time can be markedly reduced. With promising results at 3 T, there is a necessity to evaluate the performance at 1.5 T due to wide scanner availabilities. Aim of this study is to test the feasibility of accelerated 3-dimensional (3D) MRCP with extended sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) using CS in navigator triggering and in a single breath-hold in a clinical setting at 1...
June 8, 2018: Investigative Radiology
Nadia Karina Paschke, Wiebke Neumann, Tanja Uhrig, Manuel Winkler, Eva Neumaier-Probst, Marc Fatar, Lothar Rudi Schad, Frank Gerrit Zöllner
OBJECTIVES: Sodium magnetic resonance (MR) imaging provides noninvasive insights to cellular processes by measuring tissue sodium concentration (TSC). Many clinical studies combine sodium MR imaging with clinical standard MR procedures, in which contrast media is frequently administered. This work investigates the influence of gadolinium-based contrast agents on quantification of TSC. Thus, either scan pauses between early and late contrast-enhanced acquisitions can be used efficiently or sodium imaging can be performed as the final scan after dynamic contrast-enhanced acquisition...
May 31, 2018: Investigative Radiology
Benjamin Fritz, Daniel A Müller, Reto Sutter, Moritz C Wurnig, Matthias W Wagner, Christian W A Pfirrmann, Michael A Fischer
OBJECTIVES: The aim of this study was to assess the interreader agreement and diagnostic accuracy of morphologic magnetic resonance imaging (MRI) analysis and quantitative MRI-based texture analysis (TA) for grading of cartilaginous bone tumors. MATERIALS AND METHODS: This retrospective study was approved by our local ethics committee. Magnetic resonance imaging scans of 116 cartilaginous bone neoplasms were included (53 chondromas, 26 low-grade chondrosarcomas, 37 high-grade chondrosarcomas)...
May 31, 2018: Investigative Radiology
Michael Perkuhn, Pantelis Stavrinou, Frank Thiele, Georgy Shakirin, Manoj Mohan, Dionysios Garmpis, Christoph Kabbasch, Jan Borggrefe
OBJECTIVES: The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results across heterogeneous acquisition protocols of routinely acquired clinical magnetic resonance imaging (MRI) examinations from multiple centers. MATERIALS AND METHODS: The data consisted of preoperative MRI scans (T1, T2, FLAIR, and contrast-enhanced [CE] T1) of 64 patients with an initial diagnosis of primary GB, which were acquired in 15 institutions with varying protocols...
May 31, 2018: Investigative Radiology
Shuai Leng, Kishore Rajendran, Hao Gong, Wei Zhou, Ahmed F Halaweish, Andre Henning, Steffen Kappler, Matthias Baer, Joel G Fletcher, Cynthia H McCollough
OBJECTIVE: The aims of this study were to quantitatively assess two new scan modes on a photon-counting detector computed tomography system, each designed to maximize spatial resolution, and to qualitatively demonstrate potential clinical impact using patient data. MATERIALS AND METHODS: This Health Insurance Portability Act-compliant study was approved by our institutional review board. Two high-spatial-resolution scan modes (Sharp and UHR) were evaluated using phantoms to quantify spatial resolution and image noise, and results were compared with the standard mode (Macro)...
May 28, 2018: Investigative Radiology
Salim Si-Mohamed, Arnaud Thivolet, Pierre-Emmanuel Bonnot, Daniel Bar-Ness, Vahan Képénékian, David P Cormode, Philippe Douek, Pascal Rousset
OBJECTIVES: To validate in vitro the capability of a high-spatial-resolution prototype spectral photon-counting computed tomography (SPCCT) scanner to differentiate between 2 contrast agents and to assess in vivo the image quality and the feasibility to image the peritoneal cavity in rats using the 2 contrast agents simultaneously within the vascular and peritoneal compartments. MATERIALS AND METHODS: The authors performed SPCCT imaging (100 mAs, 120 kVp) with energy bin thresholds set to 30, 51, 64, 72, and 85 keV in vitro on a custom-made polyoxymethylene cylindrical phantom consisting of tubes with dilutions of both contrast agents and in vivo on 2 groups of adult rats using 2 injection protocols...
May 23, 2018: Investigative Radiology
Marlène Rasschaert, Josef A Schroeder, Ting-Di Wu, Sergio Marco, Andréa Emerit, Heiko Siegmund, Claudia Fischer, Nathalie Fretellier, Jean-Marc Idée, Claire Corot, Christoph Brochhausen, Jean-Luc Guerquin-Kern
PURPOSE: The aim of this study was to investigate, based on in-depth multimodal imaging, the presence of Gd deposits, their ultrastructure, location, and co-location with endogenous elements, in the cerebellum, after repeated administrations of gadolinium-based contrast agents (GBCAs). METHODS: Rats sensitized by subtotal nephrectomy received 20 daily intravenous injections of 0.6 mmol Gd/kg for 5 weeks of commercial forms of either gadoterate, gadobenate or gadodiamide, or saline (n = 2/group)...
September 2018: Investigative Radiology
Philippe Robert, Thomas Frenzel, Cécile Factor, Gregor Jost, Marlène Rasschaert, Gunnar Schuetz, Nathalie Fretellier, Janina Boyken, Jean-Marc Idée, Hubertus Pietsch
Gadolinium (Gd)-based contrast agents (GBCAs) are pharmaceuticals that have been approved for 30 years and used daily in millions of patients worldwide. Their clinical benefits are indisputable. Recently, unexpected long-term presence of Gd in the brain has been reported by numerous retrospective clinical studies and confirmed in preclinical models particularly after linear GBCA (L-GBCA) compared with macrocyclic GBCA (M-GBCA). Even if no clinical consequences of Gd presence in brain tissue has been demonstrated so far, in-depth investigations on potential toxicological consequences and the fate of Gd in the body remain crucial to potentially adapt the clinical use of GBCAs, as done during the nephrogenic systemic fibrosis crisis...
September 2018: Investigative Radiology
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