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Investigative Radiology

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https://www.readbyqxmd.com/read/28817393/increased-expiratory-computed-tomography-density-reveals-possible-abnormalities-in-radiologically-preserved-lung-parenchyma-in-idiopathic-pulmonary-fibrosis
#1
Valentina Petroulia, Manuela Funke, Pascal Zumstein, Sabina Berezowska, Lukas Ebner, Thomas Geiser, Nenad Torbica, Johannes Heverhagen, Alexander Poellinger
OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) is a progressive lethal chronic lung disease with unclear pathogenesis. Radiological hallmark is the pattern of usual interstitial pneumonia accentuated in peripheral and basal areas with otherwise preserved lung structure. One hypothesis is that alveolar collapse and consequent induration lead to fibrotic transformation of lung tissue. The aim of the study was to investigate normal-appearing tissue during expiration for signs of collapsibility and differences from other diseases or controls...
August 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28796722/accuracy-and-repeatability-of-automated-injector-versus-manual-administration-of-an-mri-contrast-agent-results-of-a-laboratory-study
#2
Jan Endrikat, Ron Barbati, Marcella Scarpa, Gregor Jost, Arthur E Ned Uber
OBJECTIVE: The aim of this study was to compare flow rates over time and the deviations from the target flow rate of a magnetic resonance imaging contrast agent achieved by an automated injector versus manual injection. MATERIALS AND METHODS: In this laboratory study, the magnetic resonance contrast agent gadobutrol was repeatedly injected by an injector and by 10 experienced technologists. Six scenarios with 2 different target flow rates (1 and 5 mL/s), 2 different contrast volumes (10 and 20 mL), and 2 different intravenous (IV) catheters (22 gauge and 20 gauge) were tested...
August 7, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28742734/evaluation-of-gadolinium-retention-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-gadobutrol-a-single-institution-experience-with-189-patients
#3
Roh-Eul Yoo, Chul-Ho Sohn, Koung Mi Kang, Tae Jin Yun, Seung Hong Choi, Ji-Hoon Kim, Sun-Won Park
OBJECTIVE: There has been controversy as to whether gadobutrol, one of the widely used macrocyclic gadolinium-based contrast agents, can lead to gadolinium retention after serial injections. Our aim was to validate whether serial administrations of gadobutrol can cause signal increase in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images due to gadolinium retention. MATERIALS AND METHODS: A total of 189 patients who had undergone at least 2 contrast-enhanced MR scans using only gadobutrol between August 2009 and August 2016 were retrospectively included...
July 24, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28742733/intravoxel-incoherent-motion-model-free-determination-of-tissue-type-in-abdominal-organs-using-machine-learning
#4
Alexander Ciritsis, Cristina Rossi, Moritz C Wurnig, Valerie Phi Van, Andreas Boss
PURPOSE: For diffusion data sets including low and high b-values, the intravoxel incoherent motion model is commonly applied to characterize tissue. The aim of the present study was to show that machine learning allows a model-free approach to determine tissue type without a priori assumptions on the underlying physiology. MATERIALS AND METHODS: In 8 healthy volunteers, diffusion data sets were acquired using an echo-planar imaging sequence with 16 b-values in the range between 0 and 1000 s/mm...
July 24, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28727616/iterative-reconstruction-may-improve-diagnosis-of-gout-an-ex-vivo-bio-phantom-dual-energy-computed-tomography-study
#5
Torsten Diekhoff, Maximilian Kotlyarov, Jürgen Mews, Bernd Hamm, Kay-Geert Armin Hermann
OBJECTIVES: We hypothesize that, compared with filtered back projection (FBP), iterative reconstruction (IR) increases the detected volume of uric acid, which serves as a measure of the sensitivity of the method, and therefore allows examinations with lower radiation exposure. Thus, the aim of our study was to evaluate the role of IR in dual-energy computed tomography (DECT) for gout assessment and volumetry in an ex vivo gout model using an epoxy phantom and a biophantom. MATERIALS AND METHODS: We prepared specimens with different concentrations of monosodium uric acid in ultrasound gel (30%-50%) and inserted them into an epoxy-based phantom and a porcine foreleg...
July 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28723713/somatotopic-fascicular-lesions-of-the-brachial-plexus-demonstrated-by-high-resolution-magnetic-resonance-neurography
#6
Tim Hilgenfeld, Johann Jende, Daniel Schwarz, Philipp Bäumer, Jennifer Kollmer, Sabine Heiland, Martin Bendszus, Mirko Pham
OBJECTIVES: The aim of this study was to evaluate whether high-resolution brachial plexus (BP) magnetic resonance neurography (MRN) is capable of (1) distinguishing patients with compressive neuropathy or noncompressive plexopathy from age- and sex-matched controls, (2) discriminating between patients with compressive neuropathy and noncompressive plexopathy, and (3) detecting spatial lesion patterns suggesting somatotopic organization of the BP. MATERIALS AND METHODS: Thirty-six patients (50...
July 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28704281/the-diagnostic-value-of-3-dimensional-sampling-perfection-with-application-optimized-contrasts-using-different-flip-angle-evolutions-space-mri-in-evaluating-lower-extremity-deep-venous-thrombus
#7
Gang Wu, Ruyi Xie, Xiaoli Zhang, John Morelli, Xu Yan, Xiaolei Zhu, Xiaoming Li
OBJECTIVES: The aim of this study was to evaluate the diagnostic performance of noncontrast magnetic resonance imaging utilizing sampling perfection with application optimized contrasts using different flip angle evolutions (SPACE) in detecting deep venous thrombus (DVT) of the lower extremity and evaluating clot burden. MATERIALS AND METHODS: This prospective study was approved by the institutional review board. Ninety-four consecutive patients (42 men, 52 women; age range, 14-87 years; average age, 52...
July 12, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28678084/magnetic-resonance-lymphography-at-9-4-t-using-a-gadolinium-based-nanoparticle-in-rats-investigations-in-healthy-animals-and-in-a-hindlimb-lymphedema-model
#8
Andreas Müller, Peter Fries, Bijan Jelvani, François Lux, Claudia E Rübe, Stephanie Kremp, Pietro Giovanoli, Arno Buecker, Michael D Menger, Matthias W Laschke, Florian S Frueh
OBJECTIVES: Magnetic resonance lymphography (MRL) in small animals is a promising but challenging tool in preclinical lymphatic research. In this study, we compared the gadolinium (Gd)-based nanoparticle AGuIX with Gd-DOTA for interstitial MRL in healthy rats and in a chronic rat hindlimb lymphedema model. MATERIALS AND METHODS: A comparative study with AGuIX and Gd-DOTA for interstitial MRL was performed in healthy Lewis rats (n = 6). For this purpose, 75 μL of 3 mM AGuIX (containing 30 mM Gd-DOTA side residues) and 75 μL 30 mM Gd-DOTA were injected simultaneously in the right and left hindlimbs...
July 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28632688/high-quality-3-dimensional-1h-magnetic-resonance-spectroscopic-imaging-of-the-prostate-without-endorectal-receive-coil-using-a-semi-laser-sequence
#9
Nassim Tayari, Isabell K Steinseifer, Kirsten M Selnæs, Tone F Bathen, Marnix C Maas, Arend Heerschap
OBJECTIVES: Inclusion of 3-dimensional H magnetic resonance spectroscopic imaging (3D-H-MRSI) in routine multiparametric MRI of the prostate requires good quality spectra and easy interpretable metabolite maps of the whole organ obtained without endorectal coil in clinically feasible acquisition times. We evaluated if a semi-LASER pulse sequence with gradient offset independent adiabaticity refocusing pulses (GOIA-sLASER) for volume selection can meet these requirements. MATERIALS AND METHODS: Thirteen patients with suspicion of prostate cancer and 1 patient known to have prostate cancer were examined at 3 T with a multichannel body-receive coil...
June 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28622249/dynamic-liver-magnetic-resonance-imaging-in-free-breathing-feasibility-of-a-cartesian-t1-weighted-acquisition-technique-with-compressed-sensing-and-additional-self-navigation-signal-for-hard-gated-and-motion-resolved-reconstruction
#10
Benjamin Kaltenbach, Andreas M Bucher, Julian L Wichmann, Dominik Nickel, Christoph Polkowski, Renate Hammerstingl, Thomas J Vogl, Boris Bodelle
OBJECTIVES: The aim of this study was to assess the feasibility of a free-breathing dynamic liver imaging technique using a prototype Cartesian T1-weighted volumetric interpolated breathhold examination (VIBE) sequence with compressed sensing and simultaneous acquisition of a navigation signal for hard-gated and motion state-resolved reconstruction. MATERIALS AND METHODS: A total of 43 consecutive oncologic patients (mean age, 66 ± 11 years; 44% female) underwent free-breathing dynamic liver imaging for the evaluation of liver metastases from colorectal cancer using a prototype Cartesian VIBE sequence (field of view, 380 × 345 mm; image matrix, 320 × 218; echo time/repetition time, 1...
June 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28622248/quantitative-perfusion-analysis-of-the-rectum-using-golden-angle-radial-sparse-parallel-magnetic-resonance-imaging-initial-experience-and-comparison-to-time-resolved-angiography-with-interleaved-stochastic-trajectories
#11
Ulrike I Attenberger, Jing Liu, Philipp Riffel, Johannes Budjan, Robert Grimm, Kai T Block, Stefan O Schoenberg, Xiaoying Wang, Daniel Hausmann
OBJECTIVES: Purpose of this study was to compare the quality of perfusion maps obtained from prototypical free-breathing magnetic resonance imaging (MRI) with continuous golden-angle radial sampling and iterative reconstruction (GRASP) to conventional acquisition using time-resolved angiography with interleaved stochastic trajectories (TWIST) in patients with rectal cancer. MATERIAL AND METHODS: Forty cases were included for retrospective analysis. Twenty of the patients received routine multiparametric MRI at 3 T for rectal cancer staging, including perfusion measurement with GRASP or TWIST (10 patients for each technique, including 5 prechemoradiation and 5 postchemoradiation)...
June 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28492418/clinical-feasibility-of-free-breathing-dynamic-t1-weighted-imaging-with-gadoxetic-acid-enhanced-liver-magnetic-resonance-imaging-using-a-combination-of-variable-density-sampling-and-compressed-sensing
#12
Jeong Hee Yoon, Mi Hye Yu, Won Chang, Jin-Young Park, Marcel Dominik Nickel, Yohan Son, Berthold Kiefer, Jeong Min Lee
OBJECTIVES: The purpose of the study was to investigate the clinical feasibility of free-breathing dynamic T1-weighted imaging (T1WI) using Cartesian sampling, compressed sensing, and iterative reconstruction in gadoxetic acid-enhanced liver magnetic resonance imaging (MRI). MATERIALS AND METHODS: This retrospective study was approved by our institutional review board, and the requirement for informed consent was waived. A total of 51 patients at high risk of breath-holding failure underwent dynamic T1WI in a free-breathing manner using volumetric interpolated breath-hold (BH) examination with compressed sensing reconstruction (CS-VIBE) and hard gating...
June 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28598900/interleaved-mapping-of-temperature-and-longitudinal-relaxation-rate-to-monitor-drug-delivery-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-induced-hyperthermia
#13
Esther Kneepkens, Edwin Heijman, Jochen Keupp, Steffen Weiss, Klaas Nicolay, Holger Grüll
OBJECTIVES: Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively to a stable, elevated temperature and a well-suited method to induce local hyperthermia (41°C-43°C) in deep-seated tissues. Magnetic Resonance (MR) imaging provides therapy planning on anatomical images and offers temperature feedback based on near-real-time MR thermometry. Although constant acquisition of MR thermometry data is crucial to ensure prolonged hyperthermia, it limits the freedom to perform measurements of other MR parameters, which are of interest during hyperthermia treatments...
June 8, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28574858/diffusion-tensor-imaging-in-chronic-inflammatory-demyelinating-polyneuropathy-diagnostic-accuracy-and-correlation-with-electrophysiology
#14
Moritz Kronlage, Kalliopi Pitarokoili, Daniel Schwarz, Tim Godel, Sabine Heiland, Min-Suk Yoon, Martin Bendszus, Philipp Bäumer
PURPOSE: The aims of this study were to assess diagnostic accuracy of diffusion tensor imaging (DTI) in chronic inflammatory demyelinating polyneuropathy (CIDP), to correlate DTI with electrophysiological parameters, and to evaluate whether radial diffusivity (RD) and axial diffusivity (AD) might serve as specific biomarkers of demyelinating and axonal pathology. MATERIALS AND METHODS: This prospective study was approved by the institutional ethics committee, and written informed consent was obtained from all participants...
June 1, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28562414/spatial-distribution-of-iron-within-the-normal-human-liver-using-dual-source-dual-energy-ct-imaging
#15
Andres F Abadia, Katharine L Grant, Kathleen E Carey, Wesley E Bolch, Richard L Morin
OBJECTIVES: Explore the potential of dual-source dual-energy (DSDE) computed tomography (CT) to retrospectively analyze the uniformity of iron distribution and establish iron concentration ranges and distribution patterns found in healthy livers. MATERIALS AND METHODS: Ten mixtures consisting of an iron nitrate solution and deionized water were prepared in test tubes and scanned using a DSDE 128-slice CT system. Iron images were derived from a 3-material decomposition algorithm (optimized for the quantification of iron)...
May 29, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28562413/renal-adiposity-confounds-quantitative-assessment-of-markers-of-renal-diffusion-with-mri-a-proposed-correction-method
#16
Behzad Ebrahimi, Ahmed Saad, Kai Jiang, Christopher M Ferguson, Hui Tang, John R Woollard, James F Glockner, Stephen C Textor, Lilach O Lerman
OBJECTIVES: Recent studies have indicated that excessive fat may confound assessment of diffusion in organs with high fat content, such as the liver and breast. However, the extent of this effect in the kidney, which is not considered a major fat deposition site, remains unclear. This study tested the hypothesis that renal fat may impact diffusion-weighted imaging (DWI) parameters, and proposes a 3-compartment model (TCM) to circumvent this effect. METHODS: Using computer simulations, we investigated the effect of fat on assessment of apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM), and TCM-derived pure-diffusivity...
May 29, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28463931/multiparametric-magnetic-resonance-imaging-of-the-prostate-repeatability-of-volume-and-apparent-diffusion-coefficient-quantification
#17
Andriy Fedorov, Mark G Vangel, Clare M Tempany, Fiona M Fennessy
OBJECTIVES: The aim of this study was to evaluate the repeatability of a region of interest (ROI) volume and mean apparent diffusion coefficient (ADC) in standard-of-care 3 T multiparametric magnetic resonance imaging (mpMRI) of the prostate obtained with the use of endorectal coil. MATERIALS AND METHODS: This prospective study was Health Insurance Portability and Accountability Act compliant, with institutional review board approval and written informed consent...
September 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28430714/ultrasound-molecular-imaging-of-inflammation-in-mouse-abdominal-aorta
#18
Shiying Wang, Sunil Unnikrishnan, Elizabeth B Herbst, Alexander L Klibanov, Frank William Mauldin, John A Hossack
OBJECTIVES: The aim of this study was to demonstrate a new clinically translatable ultrasound molecular imaging approach, modulated acoustic radiation force-based imaging, which is capable of rapid and reliable detection of inflammation as validated in mouse abdominal aorta. MATERIALS AND METHODS: Animal studies were approved by the Institutional Animal Care and Use Committee at the University of Virginia. C57BL/6 mice stimulated with tumor necrosis factor α, or fed with a high-fat diet, were used as inflammation (MInflammation) and diet-induced obesity (DIO) (MDIO) models, respectively...
September 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28379863/improved-magnetic-resonance-imaging-pathology-correlation-with-imaging-derived-3d-printed-patient-specific-whole-mount-molds-of-the-prostate
#19
Daniel N Costa, Yonatan Chatzinoff, Niccolo M Passoni, Payal Kapur, Claus G Roehrborn, Yin Xi, Neil M Rofsky, Jose Torrealba, Franto Francis, Cecil Futch, Phyllis Hagens, Hollis Notgrass, Susana Otero-Muinelo, Ivan Pedrosa, Rajiv Chopra
OBJECTIVES: The aim of this study was to compare the anatomical registration of preoperative magnetic resonance imaging (MRI) and prostate whole-mount obtained with 3D-printed, patient-specific, MRI-derived molds (PSM) versus conventional whole-mount sectioning (WMS). MATERIALS AND METHODS: Based on an a priori power analysis, this institutional review board-approved study prospectively included 50 consecutive men who underwent 3 T multiparametric prostate MRI followed by radical prostatectomy...
September 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28622247/effects-of-portal-hypertension-on-gadoxetic-acid-enhanced-liver-magnetic-resonance-diagnostic-and-prognostic-implications
#20
Ulrika Asenbaum, Ahmed Ba-Ssalamah, Mattias Mandorfer, Richard Nolz, Julia Furtner, Thomas Reiberger, Arnulf Ferlitsch, Klaus Kaczirek, Michael Trauner, Markus Peck-Radosavljevic, Andreas G Wibmer
OBJECTIVE: The aim of this study was to investigate the impact of portal hypertension (PH) on gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) and assess diagnostic and prognostic implications in comparison to established imaging features of PH. MATERIALS AND METHODS: Institutional review board-approved retrospective study of 178 patients (142 men; median age, 59.4 years) with chronic liver disease undergoing MRI and hepatic venous pressure gradient (HVPG) measurement between January 2008 and April 2015...
August 2017: Investigative Radiology
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