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Investigative Radiology

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https://www.readbyqxmd.com/read/29659381/methodological-aspects-for-preclinical-evaluation-of-gadolinium-presence-in-brain-tissue-critical-appraisal-and-suggestions-for-harmonization-a-joint-initiative
#1
Philippe Robert, Thomas Frenzel, Cécile Factor, Gregor Jost, Marlène Rasschaert, Gunnar Schuetz, Nathalie Fretellier, Janina Boyken, Jean-Marc Idée, Hubertus Pietsch
Gadolinium (Gd)-based contrast agents (GBCAs) are pharmaceuticals that have been approved for 30 years and used daily in millions of patients worldwide. Their clinical benefits are indisputable. Recently, unexpected long-term presence of Gd in the brain has been reported by numerous retrospective clinical studies and confirmed in preclinical models particularly after linear GBCA (L-GBCA) compared with macrocyclic GBCA (M-GBCA). Even if no clinical consequences of Gd presence in brain tissue has been demonstrated so far, in-depth investigations on potential toxicological consequences and the fate of Gd in the body remain crucial to potentially adapt the clinical use of GBCAs, as done during the nephrogenic systemic fibrosis crisis...
April 13, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29652699/impact-of-the-glymphatic-system-on-the-kinetic-and-distribution-of-gadodiamide-in-the-rat-brain-observations-by-dynamic-mri-and-effect-of-circadian-rhythm-on-tissue-gadolinium-concentrations
#2
Toshiaki Taoka, Gregor Jost, Thomas Frenzel, Shinji Naganawa, Hubertus Pietsch
OBJECTIVES: The glymphatic system is a recently hypothesized waste clearance system of the brain in which perivascular space constitutes a pathway similar to the lymphatic system in other body regions. Sleep and anesthesia are reported to influence the activity of the glymphatic system. Because rats are nocturnal animals, the glymphatic system is expected to be more active during the day. We attempted to elucidate the influence of the glymphatic system for intravenously injected gadodiamide in the rat brain by 2 experiments...
April 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29642081/-68ga-ga-pentixafor-pet-mri-for-cxcr4-imaging-of-chronic-lymphocytic-leukemia-preliminary-results
#3
Marius E Mayerhoefer, Ulrich Jaeger, Philipp Staber, Markus Raderer, Wolfgang Wadsak, Sarah Pfaff, Christoph Kornauth, Daniela Senn, Michael Weber, Hans-Juergen Wester, Cathrin Skrabs, Alexander Haug
OBJECTIVES: This prospective proof-of-principle study aimed to determine whether [Ga]Ga-Pentixafor uptake, which reflects CXCR4 expression, is higher in the bone marrow of chronic lymphocytic leukemia (CLL) than in other oncological diseases without bone marrow infiltration and can therefore be used for CLL imaging. MATERIALS AND METHODS: Thirteen CLL patients and 20 controls (10 with pancreatic adenocarcinoma and 10 with mucosa-associated lymphoid tissue lymphoma) with histologically proven cancer underwent [Ga]Ga-Pentixafor positron emission tomography/magnetic resonance imaging...
April 10, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29620604/diffusion-weighted-imaging-with-apparent-diffusion-coefficient-mapping-for-breast-cancer-detection-as-a-stand-alone-parameter-comparison-with-dynamic-contrast-enhanced-and-multiparametric-magnetic-resonance-imaging
#4
Katja Pinker, Linda Moy, Elizabeth J Sutton, Ritse M Mann, Michael Weber, Sunitha B Thakur, Maxine S Jochelson, Zsuzsanna Bago-Horvath, Elizabeth A Morris, Pascal At Baltzer, Thomas H Helbich
PURPOSE: The aims of this study were to compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) with apparent diffusion coefficient mapping as a stand-alone parameter without any other supportive sequence for breast cancer detection and to assess its combination as multiparametric MRI (mpMRI) of the breast. MATERIALS AND METHODS: In this institutional review board-approved single-center study, prospectively acquired data of 106 patients who underwent breast MRI from 12/2010 to 09/2014 for an imaging abnormality (Breast Imaging Reporting and Data System 0, 4/5) were retrospectively analyzed...
April 3, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29596080/low-dose-characterization-of-kidney-stones-using-spectral-detector-computed-tomography-an-ex-vivo-study
#5
Nils Große Hokamp, Johannes Salem, Albrecht Hesse, Jasmin Alexandra Holz, Manuel Ritter, Axel Heidenreich, David Maintz, Stefan Haneder
OBJECTIVES: The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS: A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline composition as determined by infrared spectroscopy were examined in a nonanthropomorphic phantom on an SDCT (IQon, Philips, Best, the Netherlands)...
March 28, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29595753/dose-efficiency-of-quarter-millimeter-photon-counting-computed-tomography-first-in-human-results
#6
Amir Pourmorteza, Rolf Symons, André Henning, Stefan Ulzheimer, David A Bluemke
PURPOSE: The aim of this study was to assess the clinical feasibility, image quality, and radiation dose implications of 0.25-mm imaging mode in a cohort of humans, achieved by dividing the photon-counting detector (PCD) size in half compared with standard-resolution photon-counting computed tomography (CT) (0.5 mm). METHODS: In this technical feasibility study, a whole-body prototype PCD-CT scanner was studied in the 0.25 mm detector mode (measured at isocenter)...
March 28, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29547493/10-years-of-nephrogenic-systemic-fibrosis-a-comprehensive-analysis-of-nephrogenic-systemic-fibrosis-reports-received-by-a-pharmaceutical-company-from-2006-to-2016
#7
Jan Endrikat, Susan Dohanish, Nicolas Schleyer, Susanne Schwenke, Sheela Agarwal, Thomas Balzer
OBJECTIVES: The aim of this study was to critically assess the evaluation and categorization process for nephrogenic systemic fibrosis (NSF) based on reports received by Bayer from 2006 to 2016. MATERIALS AND METHODS: A total of 779 NSF reports received by Bayer globally from 2006 to 2016 were included in the analysis. Arlington Medical Resources provided gadolinium-based contrast agent (GBCA) market share. Reports were conservatively categorized based on the Cowper/Girardi criteria...
March 16, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29543693/detection-of-subsolid-nodules-in-lung-cancer-screening-complementary-sensitivity-of-visual-reading-and-computer-aided-diagnosis
#8
Mario Silva, Cornelia M Schaefer-Prokop, Colin Jacobs, Giovanni Capretti, Francesco Ciompi, Bram van Ginneken, Ugo Pastorino, Nicola Sverzellati
OBJECTIVES: The aim of this study was to compare computer-aided diagnosis (CAD) and visual reading for the detection of subsolid nodules (SSNs) in volumetrl measuremic low-dose computed tomography (LDCT) for lung cancer screening. MATERIALS AND METHODS: Prospective visual detection (VD) and manuaent of SSN were performed in the 2303 baseline volumetric LDCTs of the Multicenter Italian Lung Detection trial. Baseline and 2- and 4-year LDCTs underwent retrospective CAD analysis, subsequently reviewed by 2 experienced thoracic radiologists...
March 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29543692/-x-map-2-0-for-edema-signal-enhancement-for-acute-ischemic-stroke-using-non-contrast-enhanced-dual-energy-computed-tomography
#9
Katsuyuki Taguchi, Toshihide Itoh, Matthew K Fuld, Eric Fournie, Okkyun Lee, Kyo Noguchi
OBJECTIVES: A novel imaging technique ("X-map") has been developed to identify acute ischemic lesions for stroke patients using non-contrast-enhanced dual-energy computed tomography (NE-DE-CT). Using the 3-material decomposition technique, the original X-map ("X-map 1.0") eliminates fat and bone from the images, suppresses the gray matter (GM)-white matter (WM) tissue contrast, and makes signals of edema induced by severe ischemia easier to detect. The aim of this study was to address the following 2 problems with the X-map 1...
March 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29543691/reduction-of-artifacts-caused-by-deep-brain-stimulating-electrodes-in-cranial-computed-tomography-imaging-by-means-of-virtual-monoenergetic-images-metal-artifact-reduction-algorithms-and-their-combination
#10
Nils Große Hokamp, Alexandra Hellerbach, Andreas Gierich, David W Jordan, Veerle Visser-Vandewalle, David Maintz, Stefan Haneder
OBJECTIVES: The aim of this study was to evaluate the reduction of artifacts from deep brain stimulation electrodes (DBS) using an iterative metal artifact reduction algorithm (O-MAR), virtual monoenergetic images (VMI), and both in combination in postoperative spectral detector computed tomography using a dual-layer detector (spectral detector computed tomography [SDCT]) of the head. MATERIAL AND METHODS: Nonanthropomorphic phantoms with different DBS leads were examined on SDCT; in 1 phantom periprocedural bleeding was simulated...
March 14, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29521888/assessment-of-low-grade-meniscal-and-cartilage-damage-of-the-knee-at-7-t-a-comparison-to-3-t-imaging-with-arthroscopic-correlation
#11
Björn Friebe, Martin Richter, Susanne Penzlin, Christian Stärke, Siegfried Kropf, Christoph Lohmann, Frank Fischbach, Oliver Speck
OBJECTIVES: The aim of this study was to compare the assessment of low-grade meniscal tears and cartilage damage in ultrahigh-field magnetic resonance imaging (MRI) at 7 T to routine clinical MRI at 3 T. MATERIALS AND METHODS: This study was approved by the local ethics committee, and written informed consent was obtained from each patient. Forty-one patients with suspected meniscal damage or mild osteoarthritis (Kellgren-Lawrence score, 0-2) received 7 T as well as routine clinical 3 T consecutively...
March 8, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29505487/pulmonary-function-diagnosis-based-on-respiratory-changes-in-lung-density-with-dynamic-flat-panel-detector-imaging-an-animal-based-study
#12
Rie Tanaka, Tohru Tani, Norihisa Nitta, Takahisa Tabata, Noritsugu Matsutani, Shintaro Muraoka, Tsutomu Yoneyama, Shigeru Sanada
OBJECTIVES: The aims of this study were to address the relationship between respiratory changes in image density of the lungs and tidal volume, to compare the changes between affected and unaffected lobes, and to apply this new technique to the diagnosis of atelectasis. MATERIALS AND METHODS: Our animal care committee approved this prospective animal study. Sequential chest radiographs of 4 pigs were obtained under respiratory control with a ventilator using a dynamic flat-panel detector system...
March 2, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29494350/continuous-hepatic-arterial-multiphase-magnetic-resonance-imaging-during-free-breathing
#13
Jakob Weiss, Mike Notohamiprodjo, Jana Taron, Petros Martirosian, Dominik Nickel, Fabian Bamberg, Konstantin Nikolaou, Ahmed E Othman
PURPOSE: The aim of this study was to evaluate the feasibility of a prototype volume-interpolated breath-hold examination (VIBE) sequence using compressed sensing (VIBECS) for rapid multiphase arterial magnetic resonance imaging (MRI) at different temporal resolution during free-breathing in comparison with a conventional breath-hold approach (VIBESTD). MATERIAL AND METHODS: A total of 40 patients with liver malignancies were prospectively included in this study and underwent contrast-enhanced liver MRI at 1...
February 28, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29494349/phenotypic-multiorgan-involvement-of-subclinical-disease-as-quantified-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-normal-glucose-tolerance
#14
Corinna Storz, Susanne Rospleszcz, Roberto Lorbeer, Holger Hetterich, Sigrid D Auweter, Wieland Sommer, Jürgen Machann, Sergios Gatidis, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Maximilian Reiser, Udo Hoffmann, Annette Peters, Christopher L Schlett, Fabian Bamberg
INTRODUCTION: Detailed mechanisms in the pathophysiology of diabetes disease are poorly understood, but structural alterations in various organ systems incur an elevated risk for cardiovascular events and adverse outcome. The aim of this study was to compare multiorgan subclinical disease phenotypes by magnetic resonance (MR) imaging to study differences between subjects with prediabetes, diabetes, and normal controls. MATERIALS AND METHODS: Subjects without prior cardiovascular disease were enrolled in a prospective case-control study and underwent multiorgan MR for the assessment of metabolic and arteriosclerotic alterations, including age-related white matter changes, hepatic proton density fat fraction, visceral adipose tissue volume, left ventricular remodeling index, carotid plaque, and late gadolinium enhancement...
February 28, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29489560/dual-energy-computed-tomography-based-display-of-bone-marrow-edema-in-incidental-vertebral-compression-fractures-diagnostic-accuracy-and-characterization-in-oncological-patients-undergoing-routine-staging-computed-tomography
#15
Claudia Frellesen, Mehrnoush Azadegan, Simon S Martin, Katharina Otani, Tommaso DʼAngelo, Christian Booz, Katrin Eichler, Bita Panahi, Moritz Kaup, Ralf W Bauer, Thomas J Vogl, Julian L Wichmann
PURPOSE: The aim of this study was to evaluate the diagnostic performance of virtual noncalcium (VNCa) dual-energy computed tomography (DECT) reconstructions enabling visualization of bone marrow edema for characterization of incidental thoracolumbar compression fractures in routine thoracoabdominal staging computed tomography (CT). MATERIALS AND METHODS: We retrospectively analyzed 51 oncological patients without suspected fracture or indicative complaints presenting at least 1 thoracolumbar compression fracture on routine thoracoabdominal staging DECT who had been examined between October 2015 and June 2017 using third-generation dual-source CT, had a previous CT within 3 months before, and also had undergone additional magnetic resonance imaging within 14 days, which served as the standard of reference...
February 27, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29470194/magnetization-transfer-ratio-in-peripheral-nerve-tissue-does-it-depend-on-age-or-location
#16
Jennifer Kollmer, Thorsten Kästel, Johann M E Jende, Martin Bendszus, Sabine Heiland
BACKGROUND AND PURPOSE: Magnetization transfer contrast imaging provides indirect information on the concentration of "bound" water protons and their interactions with "free" water molecules. The purpose of this study is to analyze location- and age-dependent changes in the magnetization transfer ratio (MTR) of lower extremity nerves. MATERIALS AND METHODS: Ten younger (20-32 years) and 5 older (50-63 years) healthy volunteers underwent magnetization transfer contrast imaging at 3 Tesla Two 3-dimensional gradient echo sequences with and without an off-resonance saturation pulse (repetition time: 58 milliseconds; echo time: 2...
February 21, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29470193/breakthrough-reactions-to-gadobenate-dimeglumine
#17
Zeeshaan S Bhatti, Benjamin M Mervak, Jonathan R Dillman, Matthew S Davenport
PURPOSE: The aim of this study was to determine the severity of breakthrough reactions to gadobenate dimeglumine in patients premedicated with a 13-hour premedication regimen. METHODS: Institutional review board approval was obtained and informed consent waived for this Health Insurance Portability and Accountability Act-compliant retrospective cohort study. All acute allergic-like reactions to gadobenate dimeglumine from 11/1/2008 to 1/31/2016 were identified. Of these, 19 allergic-like reactions followed 13-hour premedication: 150 mg prednisone and 50 mg diphenhydramine (ie, "breakthrough reactions")...
February 21, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29462023/advocating-the-development-of-next-generation-high-relaxivity-gadolinium-chelates-for-clinical-magnetic-resonance
#18
Val M Runge, Johannes T Heverhagen
The question of improved relaxivity, and potential efficacy therein, for a next-generation of magnetic resonance gadolinium chelates with extracellular distribution and renal excretion, which could also be viewed from the perspective of dose, is addressed on the basis of historical development, animal experimentation, and human trials. There was no systematic evaluation that preceded the choice of 0.1 mmol/kg as the standard dose for human imaging with the gadolinium chelates. In part, this dose was chosen owing to bloodwork abnormalities seen in phase I and phase II studies...
February 17, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29462024/characterization-of-small-renal-tumors-with-magnetic-resonance-elastography-a-feasibility-study
#19
Davide Prezzi, Radhouene Neji, Christian Kelly-Morland, Hema Verma, Tim OʼBrien, Ben Challacombe, Archana Fernando, Ashish Chandra, Ralph Sinkus, Vicky Goh
OBJECTIVES: The aim of this study was to explore the feasibility of magnetic resonance elastography (MRE) for characterizing indeterminate small renal tumors (SRTs) as part of a multiparametric magnetic resonance (MR) imaging protocol. MATERIALS AND METHODS: After institutional review board approval and informed consent were obtained, 21 prospective adults (15 men; median age, 55 years; age range, 25-72 years) with SRT were enrolled. Tumors (2-5 cm Ø) were imaged using 3-directional, gradient echo MRE...
February 16, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29438139/optimizing-pulmonary-embolism-computed-tomography-in-the-age-of-individualized-medicine-a-prospective-clinical-study
#20
Babs M F Hendriks, Nienke G Eijsvoogel, Madeleine Kok, Bibi Martens, Joachim E Wildberger, Marco Das
PURPOSE: The aim of the study was to simultaneously optimize contrast media (CM) injection and scan parameters for the individual patient during computed tomography pulmonary angiography (CTPA). METHODS: In this study (NCT02611115), 235 consecutive patients suspected of having pulmonary embolism were prospectively enrolled. Automated kV selection software on a third-generation multidetector computed tomography adapted tube voltage to the individual patient, based on scout scans...
February 12, 2018: Investigative Radiology
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