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JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#2
JOURNAL ARTICLE
Emma O'Shaughnessy, Lucile Senicourt, Natasha Mambour, Julien Savatovsky, Loïc Duron, Augustin Lecler
BACKGROUND: Orbital tumors present a diagnostic challenge due to their varied locations and histopathological differences. Although recent advancements in imaging have improved diagnosis, classification remains a challenge. The integration of artificial intelligence in radiology and ophthalmology has demonstrated promising outcomes. PURPOSE: This study aimed to evaluate the performance of machine learning models in accurately distinguishing malignant orbital tumors from benign ones using multiparametric 3 T magnetic resonance imaging (MRI) data...
April 11, 2024: Investigative Radiology
#3
JOURNAL ARTICLE
Georg C Feuerriegel, Adrian A Marth, Sophia S Goller, Monika Hilbe, Stefan Sommer, Reto Sutter
OBJECTIVES: The aim of this study was to qualitatively and quantitatively assess changes in bovine flexor tendons before and after collagen degradation and at different angles in relation to the static B0 field using 3-dimensional ultra-short echo time (UTE) magnetization transfer (MT) imaging within a clinically feasible acquisition time. MATERIALS AND METHODS: Eight bovine flexor tendons were examined at 3 T magnetic resonance imaging including 3-dimensional UTE MT and UTE T2* research application sequences (acquired within 4:04 and 6:38 minutes, respectively) before and after enzyme-induced degradation...
April 10, 2024: Investigative Radiology
#4
JOURNAL ARTICLE
Ferhan Baskaya, Teresa Lemainque, Barbara Klinkhammer, Susanne Koletnik, Saskia von Stillfried, Steven R Talbot, Peter Boor, Volkmar Schulz, Wiltrud Lederle, Fabian Kiessling
OBJECTIVES: Chronic liver diseases (CLDs) have diverse etiologies. To better classify CLDs, we explored the ability of longitudinal multiparametric MRI (magnetic resonance imaging) in depicting alterations in liver morphology, inflammation, and hepatocyte and macrophage activity in murine high-fat diet (HFD)- and carbon tetrachloride (CCl4)-induced CLD models. MATERIALS AND METHODS: Mice were either untreated, fed an HFD for 24 weeks, or injected with CCl4 for 8 weeks...
April 10, 2024: Investigative Radiology
#5
JOURNAL ARTICLE
Wei Zhou, Donglai Huo, Lorna P Browne, Xin Zhou, Jason Weinman
OBJECTIVES: The purpose of this study is to determine if a universal 120-kV ultra-high pitch and virtual monoenergetic images (VMIs) protocol on the photon-counting computed tomography (PCCT) system can provide sufficient image quality for pediatric abdominal imaging, regardless of size, compared with protocols using a size-dependent kV and dual-source flash mode on the energy-integrating CT (EICT) system. MATERIALS AND METHODS: One solid water insert and 3 iodine (2, 5, 10 mg I/mL) inserts were attached or inserted into phantoms of variable sizes, simulating the abdomens of a newborn, 5-year-old, 10-year-old, and adult-sized pediatric patients...
April 10, 2024: Investigative Radiology
#6
JOURNAL ARTICLE
Jens Johansson, Kerstin Lagerstrand, Isabella M Björkman-Burtscher, Mats Laesser, Hanna Hebelka, Stephan E Maier
OBJECTIVES: Increasing gradient performance on modern magnetic resonance imaging scanners has profoundly reduced the attainable diffusion and echo times for clinically available pulsed-gradient spin echo (PGSE) sequences. This study investigated how this may impact the measured apparent diffusion coefficient (ADC), which is considered an important diagnostic marker for differentiation between normal and abnormal brain tissue and for therapeutic follow-up. MATERIALS AND METHODS: Diffusion time and echo time dependence of the ADC were evaluated on a high-performance 3 T magnetic resonance imaging scanner...
April 9, 2024: Investigative Radiology
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JOURNAL ARTICLE
Thomas Werncke, Lena S Becker, Sabine K Maschke, Jan B Hinrichs, Timo C H Meine, Cornelia L A Dewald, Inga Brüsch, Regina Rumpel, Frank K Wacker, Bernhard C Meyer
OBJECTIVES: This phantom and animal pilot study aimed to compare image quality and radiation exposure between detector-dose-driven exposure control (DEC) and contrast-to-noise ratio (CNR)-driven exposure control (CEC) as functions of source-to-image receptor distance (SID) and collimation. MATERIALS AND METHODS: First, an iron foil simulated a guide wire in a stack of polymethyl methacrylate and aluminum plates representing patient thicknesses of 15, 25, and 35 cm...
March 27, 2024: Investigative Radiology
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JOURNAL ARTICLE
Thomas Sartoretti, Michael C McDermott, Lion Stammen, Bibi Martens, Lukas J Moser, Gregor Jost, Hubertus Pietsch, Ralf Gutjahr, Tristan Nowak, Bernhard Schmidt, Thomas G Flohr, Joachim E Wildberger, Hatem Alkadhi
OBJECTIVES: Calcified plaques induce blooming artifacts in coronary computed tomography angiography (CCTA) potentially leading to inaccurate stenosis evaluation. Tungsten represents a high atomic number, experimental contrast agent with different physical properties than iodine. We explored the potential of a tungsten-based contrast agent for photon-counting detector (PCD) CCTA in heavily calcified coronary vessels. MATERIALS AND METHODS: A cardiovascular phantom exhibiting coronaries with calcified plaques was imaged on a first-generation dual-source PCD-CT...
March 25, 2024: Investigative Radiology
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JOURNAL ARTICLE
Giulia Baldini, René Hosch, Cynthia S Schmidt, Katarzyna Borys, Lennard Kroll, Sven Koitka, Patrizia Haubold, Obioma Pelka, Felix Nensa, Johannes Haubold
OBJECTIVES: Accurately acquiring and assigning different contrast-enhanced phases in computed tomography (CT) is relevant for clinicians and for artificial intelligence orchestration to select the most appropriate series for analysis. However, this information is commonly extracted from the CT metadata, which is often wrong. This study aimed at developing an automatic pipeline for classifying intravenous (IV) contrast phases and additionally for identifying contrast media in the gastrointestinal tract (GIT)...
March 4, 2024: Investigative Radiology
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JOURNAL ARTICLE
Clinical Safety of Gadobutrol: Review of Over 25 Years of Use Exceeding 100 Million Administrations.
Jan Endrikat, Matthias Gutberlet, Karl-Titus Hoffmann, Laura Schöckel, Aasia Bhatti, Cornelia Harz, Jörg Barkhausen
BACKGROUND: The macrocyclic gadolinium-based contrast agent gadobutrol was introduced to the market in February 1998. Over the last 25 years, gadobutrol has been administered more than 100 million times worldwide providing a wealth of data related to safety. OBJECTIVE: The aim of this study was to perform a thorough review and status update on gadobutrol's safety. MATERIALS AND METHODS: Safety data from the clinical phase II-IV program and postmarketing surveillance were descriptively analyzed from February 1998 until December 31, 2022...
March 1, 2024: Investigative Radiology
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JOURNAL ARTICLE
Sanja Bogdanovic, Matthias Staib, Marco Schleiniger, Livio Steiner, Leonardo Schwarz, Christoph Germann, Reto Sutter, Benjamin Fritz
OBJECTIVES: The aim of this study was to clinically validate a fully automated AI model for magnetic resonance imaging (MRI)-based quantifications of lumbar spinal canal stenosis. MATERIALS AND METHODS: This retrospective study included lumbar spine MRI of 100 consecutive clinical patients (56 ± 17 years; 43 females, 57 males) performed on clinical 1.5 (51 examinations) and 3 T MRI scanners (49 examinations) with heterogeneous clinical imaging protocols. The AI model performed segmentations of the thecal sac on axial T2-weighted sequences...
March 1, 2024: Investigative Radiology
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JOURNAL ARTICLE
Marcel Tschopp, Christian W A Pfirrmann, Florian Brunner, Sandro F Fucentese, Julien Galley, Christoph Stern, Reto Sutter, Sabrina Catanzaro, Nathalie Kühne, Andrea B Rosskopf
BACKGROUND: Intra-articular injections are routinely used for conservative treatment of knee osteoarthritis (OA). The detailed comparative therapeutic effects of these injections on cartilage tissue are still unclear. OBJECTIVE: The aim of this study was to detect and compare knee cartilage changes after intra-articular injection of glucocorticoid, hyaluronic acid, or platelet-rich plasma (PRP) to placebo using quantitative (T2 and T2* mapping) and morphological magnetic resonance imaging parameters in patients with mild or moderate osteoarthritis...
February 28, 2024: Investigative Radiology
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JOURNAL ARTICLE
Sara Boccalini, Charles Mayard, Hugo Lacombe, Marjorie Villien, Salim Si-Mohamed, François Delahaye, Loic Boussel, Ricardo P J Budde, Matteo Pozzi, Philippe Douek
BACKGROUND AND PURPOSE: The contribution of cardiac computed tomography (CT) for the detection and characterization of prosthetic heart valve (PHV) complications is still limited due mainly to artifacts. Computed tomography systems equipped with photon-counting detectors (PCDs) have the potential to overcome these limitations. Therefore, the aim of the study was to compare image quality of PHV with PCD-CT and dual-energy dual-layer CT (DEDL-CT). MATERIALS AND METHODS: Two metallic and 3 biological PHVs were placed in a tube containing diluted iodinated contrast inside a thoracic phantom and scanned repeatedly at different angles on a DEDL-CT and PCD-CT...
February 28, 2024: Investigative Radiology
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JOURNAL ARTICLE
Georg C Feuerriegel, Sophia S Goller, Constantin von Deuster, Reto Sutter
OBJECTIVES: The aim of this study was to assess the diagnostic value and accuracy of a deep learning (DL)-accelerated fluid attenuated inversion recovery (FLAIR) sequence with fat saturation (FS) in patients with inflammatory synovitis of the knee. MATERIALS AND METHODS: Patients with suspected knee synovitis were retrospectively included between January and September 2023. All patients underwent a 3 T knee magnetic resonance imaging including a DL-accelerated noncontrast FLAIR FS sequence (acquisition time: 1 minute 38 seconds) and a contrast-enhanced (CE) T1-weighted FS sequence (acquisition time: 4 minutes 50 seconds), which served as reference standard...
February 8, 2024: Investigative Radiology
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JOURNAL ARTICLE
Henner Huflage, Robin Hendel, Piotr Woznicki, Nora Conrads, Philipp Feldle, Theresa Sophie Patzer, Süleyman Ergün, Thorsten Alexander Bley, Andreas Steven Kunz, Jan-Peter Grunz
OBJECTIVES: Image acquisition in ultra-high-resolution (UHR) scan mode does not impose a dose penalty in photon-counting CT (PCCT). This study aims to investigate the dose saving potential of using UHR instead of standard-resolution PCCT for lumbar spine imaging. MATERIALS AND METHODS: Eight cadaveric specimens were examined with 7 dose levels (5-35 mGy) each in UHR (120 × 0.2 mm) and standard-resolution acquisition mode (144 × 0.4 mm) on a first-generation PCCT scanner...
February 8, 2024: Investigative Radiology
#16
JOURNAL ARTICLE
Lukas Jakob Moser, Victor Mergen, Thomas Allmendinger, Robert Manka, Matthias Eberhard, Hatem Alkadhi
PURPOSE: Prospective electrocardiography-triggering is one of the most commonly used cardiac computed tomography (CT) scan modes but can be susceptible to stair-step artifacts in the transition areas of an acquisition over multiple cardiac cycles. We evaluated a novel reconstruction algorithm to reduce the occurrence and severity of such artifacts in sequential coronary CT angiography. MATERIALS AND METHODS: In this institutional review board-approved, retrospective study, 50 consecutive patients (16 females; mean age, 58...
January 30, 2024: Investigative Radiology
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JOURNAL ARTICLE
Connor Krolak, Manjiri Dighe, Alicia Clark, Marissa Shumaker, Raymond Yeung, Richard G Barr, Yuko Kono, Michalakis Averkiou
OBJECTIVE: The aim of this study is to describe a comprehensive contrast-enhanced ultrasound (CEUS) imaging protocol and analysis method to implement CEUS LI-RADS (Liver Imaging Reporting and Data System) in a quantifiable manner. The methods that are validated with a prospective single-center study aim to simplify CEUS LI-RADS evaluation, remove observer bias, and potentially improve the sensitivity of CEUS LI-RADS. MATERIALS AND METHODS: This prospective single-center study enrolled patients with hepatocellular carcinoma (April 2021-June 2022; N = 31; mean age ± SD, 67 ± 6 years; 24 men/7 women)...
April 1, 2024: Investigative Radiology
#18
JOURNAL ARTICLE
Dongjun Li, Michael Kirberger, Jingjuan Qiao, Zongxiang Gui, Shenghui Xue, Fan Pu, Jie Jiang, Yiting Xu, Shanshan Tan, Mani Salarian, Oluwatosin Ibhagui, Khan Hekmatyar, Jenny J Yang
Cancer and other acute and chronic diseases are results of perturbations of common molecular determinants in key biological and signaling processes. Imaging is critical for characterizing dynamic changes in tumors and metastases, the tumor microenvironment, tumor-stroma interactions, and drug targets, at multiscale levels. Magnetic resonance imaging (MRI) has emerged to be a primary imaging modality for both clinical and preclinical applications due to its advantages over other modalities, including sensitivity to soft tissues, nondepth limitations, and the use of nonionizing radiation...
February 1, 2024: Investigative Radiology
#19
JOURNAL ARTICLE
Luis Hummel, Thomas Frenzel, Janina Boyken, Hubertus Pietsch, Erdmann Seeliger
OBJECTIVES: After the administration of gadolinium-based contrast agents (GBCAs), residual gadolinium (Gd) has been detected in a few distinct morphological structures of the central nervous system (CNS). However, a systematic, comprehensive, and quantitative analysis of the spatial Gd distribution in the entire brain is not yet available. The first aim of this study is to provide this analysis in healthy rats after administration of high GBCA doses. The second aim is to assess the spatial distributions and possible Gd colocalizations of endogenous iron (Fe), manganese (Mn), and phosphorus (P)...
February 1, 2024: Investigative Radiology
#20
REVIEW
Johannes Haubold, René Hosch, Gregor Jost, Felix Kreis, Michael Forsting, Hubertus Pietsch, Felix Nensa
Artificial intelligence (AI) techniques are currently harnessed to revolutionize the domain of medical imaging. This review investigates 3 major AI-driven approaches for contrast agent management: new frontiers in contrast agent dose reduction, the contrast-free question, and new applications. By examining recent studies that use AI as a new frontier in contrast media research, we synthesize the current state of the field and provide a comprehensive understanding of the potential and limitations of AI in this context...
February 1, 2024: Investigative Radiology
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