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Investigative Radiology

Paola Clauser, Pascal A T Baltzer, Panagiotis Kapetas, Ramona Woitek, Michael Weber, Federica Leone, Maria Bernathova, Thomas H Helbich
OBJECTIVES: The aim of this study was to evaluate the detection rate and diagnostic performance of 2-dimensional synthetic mammography (SM) as an adjunct to wide-angle digital breast tomosynthesis (WA-DBT) compared with digital mammography (DM) alone or to DM in combination with WA-DBT. MATERIALS AND METHODS: There were 205 women with 179 lesions included in this retrospective reader study. Patients underwent bilateral, 2-view (2v) DM and WA-DBT between March and June 2015...
October 2, 2018: Investigative Radiology
Hyo-Jin Kang, Jeong Min Lee, Su Joa Ahn, Jae Seok Bae, Stephan Kannengiesser, Berthold Kiefer, Kyung-Suk Suh
OBJECTIVES: The aim of this study was to evaluate the clinical feasibility of gadoxetic acid-enhanced isotropic high-resolution (IHR) 3-dimensional (3D) T1-weighted (T1W) magnetic resonance cholangiography (MRC) using an iterative denoising (ID) algorithm for evaluation of the biliary anatomy of living liver donors in comparison with conventional 3D multislice T2-weighted (T2W) MRC. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, a total of 75 living liver donors who underwent conventional 3D multislice T2W-MRC and IHR-3D-T1W-MRC on a 3 T scanner and subsequent right hepatectomy for liver donation were included...
October 2, 2018: Investigative Radiology
Malte N Bongers, Georg Bier, Christoph Schabel, Jan Fritz, Marius Horger
PURPOSE: The aim of this study to evaluate the role of frequency-selective nonlinear blending (FS-NLB) for the detectability of brain metastases with contrast-enhanced computed tomography (CECT) using magnetic resonance imaging (MRI) as standard of reference. MATERIALS AND METHODS: A retrospective patient data search at our institution yielded 91 patients who underwent both brain CECT and MRI for screening of brain metastases (n = 173) between 2014 and 2016 (mean time interval, 29 ± 37 [malignant: 15 ± 16/benign: 42 ± 47] days)...
October 2, 2018: Investigative Radiology
Donna R Roberts, Arindam R Chatterjee
No abstract text is available yet for this article.
September 28, 2018: Investigative Radiology
Khoschy Schawkat, Dilmurodjon Eshmuminov, Daniela Lenggenhager, Katharina Endhardt, Bart Vrugt, Andreas Boss, Henrik Petrowsky, Pierre-Alain Clavien, Caecilia S Reiner
OBJECTIVES: The purpose of this study was to evaluate the diagnostic performance of magnetization transfer (MT) imaging and multigradient echo magnetic resonance imaging (MRI) to quantify pancreatic fibrosis and lipomatosis in patients before pancreatoduodenectomy for postoperative risk stratification with histopathology as the reference standard. MATERIALS AND METHODS: Twenty-four patients (age, 68 ± 8 years, 16 males) prospectively underwent quantitative MT imaging using a 2-dimensional gradient echo sequence with and without MT prepulse and multigradient echo imaging on a 3 T MRI 1 day before pancreatoduodenectomy due to adenocarcinoma of the pancreatic head region (n = 20), neuroendocrine tumor (n = 3), or intraductal papillary mucinous neoplasm (n = 1)...
September 20, 2018: Investigative Radiology
Stephan Rodrigo Marticorena Garcia, Markus Grossmann, Anne Bruns, Michael Dürr, Heiko Tzschätzsch, Bernd Hamm, Jürgen Braun, Ingolf Sack, Jing Guo
OBJECTIVES: The aim of this study was to test multiparametric magnetic resonance imaging including blood oxygen level-dependent (BOLD) imaging by T2* mapping, magnetic resonance elastography (MRE) by tomoelastography, and diffusion-weighted imaging (DWI) for detecting nephropathy in patients with lupus nephritis (LN). METHODS: Forty-one subjects (25 patients with LN and 16 age- and sex-matched healthy volunteers; LN: mean age, 47.3 ± 14.8 years; 22 female subjects; volunteers: mean age, 43...
September 15, 2018: Investigative Radiology
David J Winkel, Tobias Heye, Thomas J Weikert, Daniel T Boll, Bram Stieltjes
OBJECTIVE: The aim of this study was to test the diagnostic performance of a deep learning-based triage system for the detection of acute findings in abdominal computed tomography (CT) examinations. MATERIALS AND METHODS: Using a RIS/PACS (Radiology Information System/Picture Archiving and Communication System) search engine, we obtained 100 consecutive abdominal CTs with at least one of the following findings: free-gas, free-fluid, or fat-stranding and 100 control cases with absence of these findings...
September 7, 2018: Investigative Radiology
Akifumi Hagiwara, Masaaki Hori, Julien Cohen-Adad, Misaki Nakazawa, Yuichi Suzuki, Akihiro Kasahara, Moeko Horita, Takuya Haruyama, Christina Andica, Tomoko Maekawa, Koji Kamagata, Kanako Kunishima Kumamaru, Osamu Abe, Shigeki Aoki
OBJECTIVES: The aim of this study was to evaluate the linearity, bias, intrascanner repeatability, and interscanner reproducibility of quantitative values derived from a multidynamic multiecho (MDME) sequence for rapid simultaneous relaxometry. MATERIALS AND METHODS: The NIST/ISMRM (National Institute of Standards and Technology/International Society for Magnetic Resonance in Medicine) phantom, containing spheres with standardized T1 and T2 relaxation times and proton density (PD), and 10 healthy volunteers, were scanned 10 times on different days and 2 times during the same session, using the MDME sequence, on three 3 T scanners from different vendors...
September 5, 2018: Investigative Radiology
Chiara Giraudo, Stanislav Motyka, Michael Weber, Thorsten Feiweier, Siegfried Trattnig, Wolfgang Bogner
OBJECTIVE: The aim of this study was to assess and compare the overall performance, reliability, variability, as well as the accuracy of diffusion tensor imaging (DTI) and fiber tracking metrics, for the muscles of the calf at 3 T and 7 T. MATERIALS AND METHODS: Ten volunteers (5 males; mean age, 29.1 ± 4.7 years), with no history of muscle disease, were examined twice at 3 T and 7 T, using a stimulated-echo acquisition mode DTI sequence. Signal-to-noise ratio (SNR) and DTI metrics (track numbers [trn], length [trl], volume [trv], fractional anisotropy [FA], mean [MD], axial [AD], and radial diffusivity [RD]) of the whole-calf muscles, the tibialis anterior, the gastrocnemius medialis, the gastrocnemius lateralis, and the soleus were collected...
August 28, 2018: Investigative Radiology
Tim Finkenstaedt, Palanan Siriwanarangsun, Suraj Achar, Michael Carl, Sina Finkenstaedt, Nirusha Abeydeera, Christine B Chung, Won C Bae
OBJECTIVES: The objective of this study was to compare the diagnostic performance and confidence of conventional, optimized, and ultrashort time to echo (UTE) magnetic resonance (MR) protocols for detection of simulated lumbar spondylolysis in human cadavers. In addition, we sought to demonstrate the feasibility of the UTE technique in subjects with and without spondylolysis. MATERIALS AND METHODS: Four human lumbar spine specimens with 46 individual pars interarticularis were randomly left intact (n = 26) or received experimental osteotomy (n = 20) using a microsurgical saw to simulate spondylolysis...
August 28, 2018: Investigative Radiology
Harrison Kim, Desiree E Morgan, Patrick Schexnailder, Rudolph M Navari, Grant R Williams, J Bart Rose, Yufeng Li, Ravikumar Paluri
OBJECTIVES: The aim of this study was to test the feasibility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with concurrent perfusion phantom for monitoring therapeutic response in patients with pancreatic ductal adenocarcinoma (PDAC). MATERIALS AND METHODS: A prospective pilot study was conducted with 8 patients (7 men and 1 woman) aged 46 to 78 years (mean age, 66 years). Participants had either locally advanced (n = 7) or metastatic (n = 1) PDAC, and had 2 DCE-MRI examinations: one before and one 8 ± 1 weeks after starting first-line chemotherapy...
August 22, 2018: Investigative Radiology
Markus M Obmann, Vanessa Kelsch, Aurelio Cosentino, Verena Hofmann, Daniel T Boll, Matthias R Benz
OBJECTIVE: The aim of the current study was to evaluate the reliability and comparability of virtual unenhanced (VUE) attenuation values derived from scans of a single-source, dual-energy computed tomography using a split-filter (tbDECT) to a dual-source dual-energy CT (dsDECT). MATERIALS AND METHODS: In this retrospective study, comparisons for tbDECT and dsDECT were made within and between different dual-energy platforms. For the interscanner comparison, 126 patients were scanned with both scanners within a time interval of 224 ± 180 days; for the intrascanner comparison, another 90 patients were scanned twice with the same scanner within a time interval of 136 ± 140 days...
August 9, 2018: Investigative Radiology
Youngjune Kim, Kyong Joon Lee, Leonard Sunwoo, Dongjun Choi, Chang-Mo Nam, Jungheum Cho, Jihyun Kim, Yun Jung Bae, Roh-Eul Yoo, Byung Se Choi, Cheolkyu Jung, Jae Hyoung Kim
OBJECTIVES: The aim of this study was to compare the diagnostic performance of a deep learning algorithm with that of radiologists in diagnosing maxillary sinusitis on Waters' view radiographs. MATERIALS AND METHODS: Among 80,475 Waters' view radiographs, examined between May 2003 and February 2017, 9000 randomly selected cases were classified as normal or maxillary sinusitis based on radiographic findings and divided into training (n = 8000) and validation (n = 1000) sets to develop a deep learning algorithm...
July 31, 2018: Investigative Radiology
Guillaume P O Marie, Polona Pozeg, Reto A Meuli, Philippe Maeder, Joachim Forget
OBJECTIVES: The purpose of the study was to systematically evaluate the precise spatial and temporal pattern of gadolinium-related changes in T1-weighted signal intensity on unenhanced magnetic resonance (MR) images, occurring in the deep brain nuclei of adult patients exposed to at least 10 consecutive doses of gadodiamide. MATERIALS AND METHODS: In this monocentric retrospective longitudinal study, we analyzed the brain MR images of 30 patients (12 women, 18 men; mean age, 43 ± 11...
July 20, 2018: Investigative Radiology
Nora N Sommer, Karla M Treitl, Eva Coppenrath, Hendrik Kooijman, Claudia Dechant, Michael Czihal, Theresa M Kolben, Sebastian E Beyer, Wieland H Sommer, Tobias Saam
OBJECTIVES: Arteritic anterior ischemic optic neuropathy (A-AION) caused by inflammatory occlusion of the posterior ciliary arteries is the most common reason for irreversible vision loss in patients with giant cell arteritis. Atypical clinical presentation and negative funduscopy can delay systemic high-dose corticosteroid therapy to prevent impending permanent blindness and involvement of the contralateral eye.The purpose of this study was to assess the diagnostic accuracy of 3-dimensional (3D) high-resolution T1-weighted black-blood magnetic resonance imaging (T1-BB-MRI) for the detection of posterior ciliary artery involvement in patients with giant cell arteritis and funduscopic A-AION...
November 2018: Investigative Radiology
Filippo Del Grande, Marco Delcogliano, Riccardo Guglielmi, Esther Raithel, Steven E Stern, Derek F Papp, Christian Candrian, Jan Fritz
OBJECTIVES: The aim of this study was to test the hypothesis that magnetic resonance imaging (MRI) of the knee with 10-minute 3-dimensional (3D) controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) sampling perfection with application optimized contrast using different flip angle evolutions (SPACE) turbo spin echo (TSE) protocols can replace 20-minute 2-dimensional (2D) TSE standard-of-reference protocols for the diagnosis of internal derangement. MATERIALS AND METHODS: After internal review board approval and prospective informed consent, 100 symptomatic subjects underwent MRI of the knee at 3 T and 50 symptomatic subjects at 1...
November 2018: Investigative Radiology
Keitaro Sofue, Toshihide Itoh, Satoru Takahashi, Bernhard Schmidt, Ryuji Shimada, Noriyuki Negi, Kazuro Sugimura, Takamichi Murakami
OBJECTIVE: The aim of this study was to assess the ability of third-generation dual-source dual-energy computed tomography to quantify cisplatin concentration using a 3-material decomposition algorithm in an experimental phantom. MATERIALS AND METHODS: Fifteen agarose-based phantoms containing various concentrations of iodine (0, 1.0, 2.0 mg I/mL) and cisplatin (0, 0.5, 1.0, 2.0, 3.0 mg Pt/mL) were scanned using third-generation dual-source dual-energy computed tomography at 80 kV and 150 kV with tin prefiltration...
November 2018: Investigative Radiology
Jana Taron, Jakob Weiss, Mike Notohamiprodjo, Thomas Kuestner, Fabian Bamberg, Elisabeth Weiland, Bernd Kuehn, Petros Martirosian
OBJECTIVES: Magnetic resonance cholangiopancreatography (MRCP) is an established technique in routine magnetic resonance examination. By applying the compressed sensing (CS) acceleration technique to conventional MRCP sequences, scan time can be markedly reduced. With promising results at 3 T, there is a necessity to evaluate the performance at 1.5 T due to wide scanner availabilities. Aim of this study is to test the feasibility of accelerated 3-dimensional (3D) MRCP with extended sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) using CS in navigator triggering and in a single breath-hold in a clinical setting at 1...
November 2018: Investigative Radiology
Benjamin Fritz, Daniel A Müller, Reto Sutter, Moritz C Wurnig, Matthias W Wagner, Christian W A Pfirrmann, Michael A Fischer
OBJECTIVES: The aim of this study was to assess the interreader agreement and diagnostic accuracy of morphologic magnetic resonance imaging (MRI) analysis and quantitative MRI-based texture analysis (TA) for grading of cartilaginous bone tumors. MATERIALS AND METHODS: This retrospective study was approved by our local ethics committee. Magnetic resonance imaging scans of 116 cartilaginous bone neoplasms were included (53 chondromas, 26 low-grade chondrosarcomas, 37 high-grade chondrosarcomas)...
November 2018: Investigative Radiology
Michael Perkuhn, Pantelis Stavrinou, Frank Thiele, Georgy Shakirin, Manoj Mohan, Dionysios Garmpis, Christoph Kabbasch, Jan Borggrefe
OBJECTIVES: The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results across heterogeneous acquisition protocols of routinely acquired clinical magnetic resonance imaging (MRI) examinations from multiple centers. MATERIALS AND METHODS: The data consisted of preoperative MRI scans (T1, T2, FLAIR, and contrast-enhanced [CE] T1) of 64 patients with an initial diagnosis of primary GB, which were acquired in 15 institutions with varying protocols...
November 2018: Investigative Radiology
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