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Investigative Radiology

Katerina Deike-Hofmann, Julia Reuter, Robert Haase, Daniel Paech, Regula Gnirs, Sebastian Bickelhaupt, Michael Forsting, Claus Peter Heußel, Heinz-Peter Schlemmer, Alexander Radbruch
BACKGROUND: The "glymphatic system" (GS), a brain-wide network of cerebrospinal fluid microcirculation, supplies a pathway through and out of the central nervous system (CNS); malfunction of the system is implicated in a variety of neurological disorders. In this exploratory study, we analyzed the potential of a new imaging approach that we coined delayed T2-weighted gadolinium-enhanced imaging to visualize the GS in vivo. METHODS: Heavily T2-weighted fluid-attenuated inversion recovery (hT2w-FLAIR) magnetic resonance imaging was obtained before, and 3 hours and 24 hours after intravenous gadolinium-based contrast agent (GBCA) application in 33 neurologically healthy patients and 7 patients with an impaired blood-brain barrier (BBB) due to cerebral metastases...
November 21, 2018: Investigative Radiology
Yuri Gorelik, Hiba Yaseen, Samuel N Heyman, Mogher Khamaisi
INTRODUCTION: The potential adverse renal outcome among patients undergoing iodine-based contrast-enhanced computerized tomography (CT) has been questioned recently, given the caution undertaken in patients' selection, hydration protocols, and the low radiocontrast volume, used with advanced imaging equipment. MATERIALS AND METHODS: This study is a retrospective assessment of renal outcome in 12,580 hospitalized patients undergoing contrast-enhanced CT, compared with 754 patients subjected to gadolinium-based magnetic resonance imaging, with subsequent propensity matching for clinical characteristics and potential risk factors...
November 21, 2018: Investigative Radiology
David J Bartlett, Chi Wan Koo, Brian J Bartholmai, Kishore Rajendran, Jayse M Weaver, Ahmed F Halaweish, Shuai Leng, Cynthia H McCollough, Joel G Fletcher
OBJECTIVES: The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT). MATERIALS AND METHODS: Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13...
November 19, 2018: Investigative Radiology
Elias Bachmann, Andrea B Rosskopf, Tobias Götschi, Markus Klarhöfer, Xeni Deligianni, Monika Hilbe, Christian W A Pfirrmann, Jess Gerrit Snedeker, Michael A Fischer
OBJECTIVES: The aim of this study was to quantitatively assess changes in collagen structure using MR T1- and T2*-mapping in a novel controlled ex vivo tendon model setup. MATERIALS AND METHODS: Twenty-four cadaveric bovine flexor tendons underwent MRI at 3 T before and after chemical modifications, representing mechanical degeneration and augmentation. Collagen degradation (COL), augmenting collagen fiber cross-linking (CXL), and a control (phosphate-buffered saline [PBS]) were examined in experimental groups, using histopathology as standard of reference...
November 16, 2018: Investigative Radiology
Christian A Hudert, Heiko Tzschätzsch, Birgit Rudolph, Hendrik Bläker, Christoph Loddenkemper, Hans-Peter Müller, Stephan Henning, Philip Bufler, Bernd Hamm, Jürgen Braun, Hermann-Georg Holzhütter, Susanna Wiegand, Ingolf Sack, Jing Guo
OBJECTIVES: Today, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adults alike. Yet, the noninvasive evaluation of disease severity remains a diagnostic challenge. In this study, we apply multifrequency magnetic resonance elastography (mMRE) for the quantification of liver steatosis and fibrosis in adolescents with NAFLD. METHODS: Fifty adolescents (age range, 10-17 years; mean BMI, 33.9 kg/m; range, 21.4-42.1 kg/m) with biopsy-proven NAFLD were included in this prospective study...
November 15, 2018: Investigative Radiology
Thomas J Vogl, Leona S Alizadeh, Richard Maeder, Nagy N Naguib, Eva Herrmann, Matthew W Bickford, Iris Burck, Moritz H Albrecht
OBJECTIVES: The aim of this study was to compare 2 advanced robotic angiography systems for real-time image guidance in terms of radiation dose and image quality (IQ) during conventional transarterial chemoembolization (C-TACE) of hepatic malignant tumors. MATERIALS AND METHODS: One hundred six patients (57 women/49 men; mean age, 60 ± 11 years) who had undergone C-TACE using 2 generations of robotic angiography platforms for image guidance were included in this retrospective study...
November 15, 2018: Investigative Radiology
Eva Heckova, Bernhard Strasser, Gilbert J Hangel, Michal Považan, Assunta Dal-Bianco, Paulus S Rommer, Petr Bednarik, Stephan Gruber, Fritz Leutmezer, Hans Lassmann, Siegfried Trattnig, Wolfgang Bogner
OBJECTIVES: The aim of this study was to assess the utility of increased spatial resolution of magnetic resonance spectroscopic imaging (MRSI) at 7 T for the detection of neurochemical changes in multiple sclerosis (MS)-related brain lesions. MATERIALS AND METHODS: This prospective, institutional review board-approved study was performed in 20 relapsing-remitting MS patients (9 women/11 men; mean age ± standard deviation, 30.8 ± 7.7 years) after receiving written informed consent...
November 14, 2018: Investigative Radiology
Bettina Baeßler, Kilian Weiss, Daniel Pinto Dos Santos
OBJECTIVES: The aim of this study was to investigate the robustness and reproducibility of radiomic features in different magnetic resonance imaging sequences. MATERIALS AND METHODS: A phantom was scanned on a clinical 3 T system using fluid-attenuated inversion recovery (FLAIR), T1-weighted (T1w), and T2-weighted (T2w) sequences with low and high matrix size. For retest data, scans were repeated after repositioning of the phantom. Test and retest datasets were segmented using a semiautomated approach...
November 14, 2018: Investigative Radiology
Marcus Raudner, Markus M Schreiner, Vladimir Juras, Michael Weber, David Stelzeneder, Claudia Kronnerwetter, Reinhard Windhager, Siegfried Trattnig
OBJECTIVES: The aim of this study was to assess the predictive value of T2 mapping at baseline with regard to the development of disk herniation and clinical outcome at a 5-year follow-up in patients with low back pain. MATERIALS AND METHODS: Twenty-five symptomatic patients (13 male; mean age, 44.0 years; range, 24-64 years at baseline) were examined at 3 T magnetic resonance imaging, with a 5-year follow-up. Region of interest analysis was performed on 125 lumbar intervertebral disks on 2 central sagittal T2 maps...
November 9, 2018: Investigative Radiology
Michael Wyss, Andrei Manoliu, Magda Marcon, Georg Spinner, Roger Luechinger, Klaas P Pruessmann, Gustav Andreisek
PURPOSE: The aim of this study was to evaluate the efficiency and performance of different fat suppression techniques for clinical 7 T knee magnetic resonance imaging including the slice-selective gradient reversal (SSGR) technique. MATERIALS AND METHODS: This article is an ethical board-approved prospective study with written informed consent from 8 volunteers (mean, 31 ± 4 years). It included fat phantom and knee magnetic resonance imaging at 3 T (Magnetom Skyra; Siemens Healthcare) and at 7 T (Achieva, Philips Healthcare)...
November 9, 2018: Investigative Radiology
Nathalie Fretellier, Agnès Granottier, Marlène Rasschaert, Anne-Laure Grindel, Fannie Baudimont, Philippe Robert, Jean-Marc Idée, Claire Corot
OBJECTIVES: The main objective of the study was to assess the effect of age on target tissue total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or gadoterate (macrocyclic) Gd-based contrast agent (GBCA) in rats. The secondary objective was to assess the potential developmental and long-term consequences of GBCA administration during neonatal and juvenile periods. MATERIALS AND METHODS: A total of 20 equivalent human clinical doses (cumulated dose, 12 mmol Gd/kg) of either gadoterate or gadodiamide were administered concurrently by the intravenous route to healthy adult and juvenile rats...
November 2, 2018: Investigative Radiology
Laura K Young, Stephen J Gandy, Lukasz Priba, Shona Z Matthew, J Graeme Houston
OBJECTIVES: The aim of this study was to examine the variation in signal intensity ratio (SIR) values in Eurospin gel phantoms and healthy volunteer (HV) brain images in response to different magnetic resonance imaging hardware and software settings. MATERIALS AND METHODS: Gel phantoms with T1 relaxation times similar to the dentate nucleus (DN), pons (P), globus palladus (GP), and thalamus (Th) were scanned using a T1-weighted 2-dimensional spin-echo sequence on 2 magnetic resonance imaging scanners (3 T and 1...
November 2, 2018: Investigative Radiology
Julia Mai, Mohamed Abubrig, Thomas Lehmann, Tom Hilbert, Elisabeth Weiland, Marc O Grimm, Ulf Teichgräber, Tobias Franiel
OBJECTIVES: The aim of the study was to determine the quantitative T2 values in prostate tissue and evaluate them for detection and grading of prostate cancer. MATERIALS AND METHODS: After approval from the local ethics committee, morphological T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps from diffusion-weighted images, quantitative T2 maps, and calculated T2w images from 75 men (median age, 66.3 years; median PSA, 8.2 ng/mL) were acquired at 3 T magnetic resonance imaging (MRI)...
November 2, 2018: Investigative Radiology
Marco Parillo, Martina Sapienza, Francesco Arpaia, Francesca Magnani, Carlo Augusto Mallio, Pasquale DʼAlessio, Carlo Cosimo Quattrocchi
OBJECTIVE: This study compares the incidence of new-onset symptoms within 24 hours after enhanced magnetic resonance imaging (eMRI) with intravenous administration of gadodiamide or gadoterate meglumine compared with a control group undergoing unenhanced MRI (uMRI). MATERIALS AND METHODS: A prospective cohort study (n = 1088 patients) was designed to assess the incidence of symptoms within 24 hours after administration of gadodiamide or gadoterate meglumine. The participants underwent a structured questionnaire by phone call before and 24 hours after the MRI scan to check for symptoms that were not present before the scan...
October 30, 2018: Investigative Radiology
Ijin Joo, Jung Hoon Kim, Sang Joon Park, Kyoungbun Lee, Nam-Joon Yi, Joon Koo Han
PURPOSE: The aim of this study was to investigate the usefulness of a personalized, 3-dimensional (3D)-printed, transparent liver model with focal liver lesions (FLLs) for lesion-by-lesion imaging-pathologic matching. MATERIALS AND METHODS: This preliminary, prospective study was approved by our institutional review board, and written informed consent was obtained. Twenty patients (male-to-female ratio, 13:7; mean age, 56 years) with multiple FLLs, including at least one presumed malignant, or an indeterminate lesion 10 mm or less on the preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI), were included...
October 30, 2018: Investigative Radiology
Lisa C Adams, Bernhard Ralla, Philipp Jurmeister, Keno K Bressem, Ute L Fahlenkamp, Bernd Hamm, Jonas Busch, Marcus R Makowski
OBJECTIVES: The aims of this study were to identify higher-grade clear cell renal cell carcinoma (cRCC) with native T1 mapping and to histologically correlate the results with the collagen volume fraction. MATERIALS AND METHODS: For this institutional review board-approved, single-center prospective study, 68 consecutive patients received abdominal magnetic resonance imaging scans at 1.5 T between January 2017 and July 2018, using a Modified Look-Locker Inversion Recovery (MOLLI) sequence...
October 30, 2018: Investigative Radiology
Janina Boyken, Thomas Frenzel, Jessica Lohrke, Gregor Jost, Gunnar Schütz, Hubertus Pietsch
OBJECTIVE: This study investigated the potential effect of the chelating agent calcium trisodium pentetate (Ca-DTPA) on the urinary excretion of gadolinium and the subsequent elimination of gadolinium (Gd) in the brain after a single intravenous administration of either a linear (gadodiamide) or a macrocyclic (gadobutrol) Gd-based contrast agent in rats. MATERIALS AND METHODS: Rats received either a single injection of gadodiamide or gadobutrol (1.8 mmol/kg, each) or saline (n = 18 per group)...
October 22, 2018: Investigative Radiology
Amirhessam Tahmassebi, Georg J Wengert, Thomas H Helbich, Zsuzsanna Bago-Horvath, Sousan Alaei, Rupert Bartsch, Peter Dubsky, Pascal Baltzer, Paola Clauser, Panagiotis Kapetas, Elizabeth A Morris, Anke Meyer-Baese, Katja Pinker
PURPOSE: The aim of this study was to assess the potential of machine learning with multiparametric magnetic resonance imaging (mpMRI) for the early prediction of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) and of survival outcomes in breast cancer patients. MATERIALS AND METHODS: This institutional review board-approved prospective study included 38 women (median age, 46.5 years; range, 25-70 years) with breast cancer who were scheduled for NAC and underwent mpMRI of the breast at 3 T with dynamic contrast-enhanced (DCE), diffusion-weighted imaging (DWI), and T2-weighted imaging before and after 2 cycles of NAC...
October 22, 2018: Investigative Radiology
Paola Clauser, Pascal A T Baltzer, Panagiotis Kapetas, Ramona Woitek, Michael Weber, Federica Leone, Maria Bernathova, Thomas H Helbich
OBJECTIVES: The aim of this study was to evaluate the detection rate and diagnostic performance of 2-dimensional synthetic mammography (SM) as an adjunct to wide-angle digital breast tomosynthesis (WA-DBT) compared with digital mammography (DM) alone or to DM in combination with WA-DBT. MATERIALS AND METHODS: There were 205 women with 179 lesions included in this retrospective reader study. Patients underwent bilateral, 2-view (2v) DM and WA-DBT between March and June 2015...
October 2, 2018: Investigative Radiology
Hyo-Jin Kang, Jeong Min Lee, Su Joa Ahn, Jae Seok Bae, Stephan Kannengiesser, Berthold Kiefer, Kyung-Suk Suh
OBJECTIVES: The aim of this study was to evaluate the clinical feasibility of gadoxetic acid-enhanced isotropic high-resolution (IHR) 3-dimensional (3D) T1-weighted (T1W) magnetic resonance cholangiography (MRC) using an iterative denoising (ID) algorithm for evaluation of the biliary anatomy of living liver donors in comparison with conventional 3D multislice T2-weighted (T2W) MRC. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, a total of 75 living liver donors who underwent conventional 3D multislice T2W-MRC and IHR-3D-T1W-MRC on a 3 T scanner and subsequent right hepatectomy for liver donation were included...
October 2, 2018: Investigative Radiology
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