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Investigative Radiology

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https://www.readbyqxmd.com/read/29215401/relaxivity-of-ferumoxytol-at-1-5-t-and-3-0-t
#1
Gesine Knobloch, Timothy Colgan, Curtis N Wiens, Xiaoke Wang, Tilman Schubert, Diego Hernando, Samir D Sharma, Scott Reeder
OBJECTIVES: The aim of this study was to determine the relaxation properties of ferumoxytol, an off-label alternative to gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T. MATERIALS AND METHODS: Ferumoxytol was diluted in gradually increasing concentrations (0.26-4.2 mM) in saline, human plasma, and human whole blood. Magnetic resonance relaxometry was performed at 37°C at 1.5 T and 3.0 T. Longitudinal and transverse relaxation rate constants (R1, R2, R2*) were measured as a function of ferumoxytol concentration, and relaxivities (r1, r2, r2*) were calculated...
December 5, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29200014/increased-delay-between-gadolinium-chelate-administration-and-t1-weighted-magnetic-resonance-imaging-acquisition-increases-contrast-enhancing-tumor-volumes-and-t1-intensities-in-brain-tumor-patients
#2
Paula L Piechotta, David Bonekamp, Martin Sill, Antje Wick, Wolfgang Wick, Martin Bendszus, Philipp Kickingereder
OBJECTIVES: The aim of this study was to evaluate the impact of delayed T1-weighted (T1-w) MRI acquisition after gadolinium chelate administration on brain tumor volumes and T1-w intensities. MATERIALS AND METHODS: Fifty-five patients with histologically confirmed, contrast-enhancing intra-axial brain tumors were analyzed in this prospective test-retest study. Patients underwent 2 consecutive 3 T MRI scans (separated by a 1-minute break) during routine follow-up with contrast-enhanced T1 (ceT1-w), T2, and FLAIR acquisition...
November 28, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29200013/computed-tomography-based-imaging-of-voxel-wise-lesion-water-uptake-in-ischemic-brain-relationship-between-density-and-direct-volumetry
#3
Gabriel Broocks, Fabian Flottmann, Marielle Ernst, Tobias Djamsched Faizy, Jens Minnerup, Susanne Siemonsen, Jens Fiehler, Andre Kemmling
OBJECTIVES: Net water uptake per volume of brain tissue may be calculated by computed tomography (CT) density, and this imaging biomarker has recently been investigated as a predictor of lesion age in acute stroke. However, the hypothesis that measurements of CT density may be used to quantify net water uptake per volume of infarct lesion has not been validated by direct volumetric measurements so far. The purpose of this study was to (1) develop a theoretical relationship between CT density reduction and net water uptake per volume of ischemic lesions and (2) confirm this relationship by quantitative in vitro and in vivo CT image analysis using direct volumetric measurements...
November 28, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29190227/potential-of-noncontrast-magnetic-resonance-imaging-with-diffusion-weighted-imaging-in-characterization-of-breast-lesions-intraindividual-comparison-with-dynamic-contrast-enhanced-magnetic-resonance-imaging
#4
Pascal A T Baltzer, Hubert Bickel, Claudio Spick, Georg Wengert, Ramona Woitek, Panagiotis Kapetas, Paola Clauser, Thomas H Helbich, Katja Pinker
OBJECTIVES: The aim of this study was to assess the potential of noncontrast magnetic resonance imaging (NC-MRI) with diffusion-weighted imaging (DWI) in characterization of breast lesions in comparison to dynamic contrast-enhanced MRI (DCE-MRI) at 3 T. MATERIALS AND METHODS: Consecutive patients with conventional imaging (mammography, ultrasound) BI-RADS 4/5 findings were included in this institutional review board-approved single-center study. All underwent 3 T breast MRI including readout-segmented DWI, DCE, and T2-weighted sequences...
November 22, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29166300/effect-of-age-on-high-t1-signal-intensity-of-the-dentate-nucleus-and-globus-pallidus-in-a-large-population-exposed-to-gadodiamide
#5
Carlo Cosimo Quattrocchi, Yuri Errante, Carlo Augusto Mallio, Luca Marinelli, Gianguido LoVullo, Gabriele Giannotti, Sabino Walter Della Sala, Aart J van der Molen, Bruno Beomonte Zobel
OBJECTIVE: The purpose of this study was to assess the effect of age and number of previous injections of gadodiamide on the signal intensity of unenhanced T1-weighted (T1w) images of the dentate nucleus and globus pallidus in a large population. MATERIALS AND METHODS: A large, single-center retrospective population survey was designed and received institutional review board approval. Between January 2014 and December 2014, T1w signal intensity ratios were obtained from a large population of 2500 consecutive enhanced brain magnetic resonance imaging (MRI) scans...
November 21, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29116960/image-quality-and-geometric-distortion-of-modern-diffusion-weighted-imaging-sequences-in-magnetic-resonance-imaging-of-the-prostate
#6
Daniel Stocker, Andrei Manoliu, Anton S Becker, Borna K Barth, Daniel Nanz, Markus Klarhöfer, Olivio F Donati
PURPOSE: The aim of this study was to compare qualitative and quantitative image quality and geometric distortion of 4 magnetic resonance diffusion-weighted imaging (DWI) sequences of the prostate using comparable imaging parameters and similar acquisition times. METHODS AND MATERIALS: Axial T2-weighted turbo spin echo images and axial DWI echo-planar imaging (EPI) sequences, including single-shot spin-echo (ss-EPI), readout-segmented multishot (rs-EPI), selective excitation-reduced field of view (sTX-EPI), and prototype single-shot technique applying slice-specific shimming (iShim-EPI) sequences, were acquired at 3 T in 10 healthy volunteers (mean age, 26...
November 8, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29112516/intravoxel-incoherent-motion-analysis-of-abdominal-organs-application-of-simultaneous-multislice-acquisition
#7
Valerie Doan Phi Van, Anton S Becker, Alexander Ciritsis, Caecilia S Reiner, Andreas Boss
PURPOSE: The aim of this study was to systematically evaluate the accuracy of quantitative intravoxel incoherent motion (IVIM) analysis of the upper abdomen applying simultaneous multislice (SMS) diffusion-weighted imaging (DWI) to reduce acquisition time. MATERIALS AND METHODS: Diffusion-weighted imaging of parenchymal abdominal organs was performed in 8 healthy volunteers at 3 T using a standard DWI sequence (acceleration factor 1 [AF1]) and an SMS-accelerated echo planar imaging sequence with acceleration factors 2 and 3 (AF2/AF3)...
November 6, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29084013/ring-like-enhancement-of-hepatocellular-carcinoma-in-gadoxetic-acid-enhanced-multiphasic-hepatic-arterial-phase-imaging-with-differential-subsampling-with-cartesian-ordering
#8
Shintaro Ichikawa, Utaroh Motosugi, Naoki Oishi, Tatsuya Shimizu, Tetsuya Wakayama, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
OBJECTIVE: The aim of this study was to evaluate the efficacy of multiphasic hepatic arterial phase (HAP) imaging using DISCO (differential subsampling with Cartesian ordering) in increasing the confidence of diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed patient consent was waived. Consecutive patients (from 2 study periods) with malignant liver nodules were examined by gadoxetic acid-enhanced magnetic resonance imaging using either multiphasic (6 phases; n = 135) or single (n = 230) HAP imaging, which revealed 519 liver nodules other than benign ones (HCC, 497; cholangiocarcinoma, 11; metastases, 10; and malignant lymphoma, 1)...
October 27, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29077588/implementation-of-a-5-minute-magnetic-resonance-imaging-screening-protocol-for-prostate-cancer-in-men-with-elevated-prostate-specific-antigen-before-biopsy
#9
Jakob Weiss, Petros Martirosian, Mike Notohamiprodjo, Sascha Kaufmann, Ahmed E Othman, Ulrich Grosse, Konstantin Nikolaou, Sergios Gatidis
PURPOSE: The aims of this study were to establish a 5-minute magnetic resonance (MR) screening protocol for prostate cancer in men before biopsy and to evaluate effects on Prostate Imaging Reporting and Data System (PI-RADS) V2 scoring in comparison to a conventional, fully diagnostic multiparametric MR imaging (mpMRI) approach. MATERIALS AND METHODS: Fifty-two patients with elevated prostate-specific antigen levels and without prior biopsy were prospectively included in this institutional review board-approved study...
October 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28727616/iterative-reconstruction-may-improve-diagnosis-of-gout-an-ex-vivo-bio-phantom-dual-energy-computed-tomography-study
#10
Torsten Diekhoff, Maximilian Kotlyarov, Jürgen Mews, Bernd Hamm, Kay Geert Hermann
OBJECTIVES: We hypothesize that, compared with filtered back projection (FBP), iterative reconstruction (IR) increases the detected volume of uric acid, which serves as a measure of the sensitivity of the method, and therefore allows examinations with lower radiation exposure. Thus, the aim of our study was to evaluate the role of IR in dual-energy computed tomography (DECT) for gout assessment and volumetry in an ex vivo gout model using an epoxy phantom and a biophantom. MATERIALS AND METHODS: We prepared specimens with different concentrations of monosodium uric acid in ultrasound gel (30%-50%) and inserted them into an epoxy-based phantom and a porcine foreleg...
October 17, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29016370/heavily-calcified-coronary-arteries-advanced-calcium-subtraction-improves-luminal-visualization-and-diagnostic-confidence-in-dual-energy-coronary-computed-tomography-angiography
#11
Domenico De Santis, Kwang Nam Jin, U Joseph Schoepf, Katharine L Grant, Carlo N De Cecco, John W Nance, Thomas J Vogl, Andrea Laghi, Moritz H Albrecht
OBJECTIVES: The aim of this study was to evaluate a prototype dual-energy computed tomography calcium subtraction algorithm and its impact on luminal visualization in patients with heavily calcified coronary arteries. MATERIALS AND METHODS: Twenty-nine patients (62% male; mean age, 64 ± 7 years) who had undergone dual-energy coronary computed tomography angiography were retrospectively included in this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study...
October 9, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28990974/iodine-and-fat-quantification-for-differentiation-of-adrenal-gland-adenomas-from-metastases-using-third-generation-dual-source-dual-energy-computed-tomography
#12
Simon S Martin, Sebastian Weidinger, Rouben Czwikla, Benjamin Kaltenbach, Moritz H Albrecht, Lukas Lenga, Thomas J Vogl, Julian L Wichmann
OBJECTIVES: The aim of this study was to investigate the value of third-generation dual-source dual-energy computed tomography (DECT) iodine and fat quantification in differentiating adrenal gland adenomas from metastases. MATERIALS AND METHODS: Sixty-two patients (38 men and 24 women; mean age, 69.1 years) underwent clinically indicated DECT of the abdomen on a third-generation dual-source scanner. Examinations were retrospectively included due to detected adrenal masses...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28990973/the-issue-of-gadolinium-retained-in-tissues-insights-on-the-role-of-metal-complex-stability-by-comparing-metal-uptake-in-murine-tissues-upon-the-concomitant-administration-of-lanthanum-and-gadolinium-diethylentriamminopentaacetate
#13
Enza Di Gregorio, Giuseppe Ferrauto, Chiara Furlan, Stefania Lanzardo, Raffaele Nuzzi, Eliana Gianolio, Silvio Aime
OBJECTIVES: The aim of the study was to explore the role of the stability of metal complexes in the processes that lead to the metal retention in the brain and other tissues of mice administered with lanthanides-based contrast agents. This issue was tackled by the simultaneous injection of gadolinium (Gd)-diethylentriamminopentaacetate (DTPA) and lanthanum-DTPA, which have the same charge and structure but differ in their thermodynamic stability by 3 orders of magnitude. MATERIALS AND METHODS: A total of 20 healthy BALB/c mice were administered by a single intravenous injection with a dose consisting of 0...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28976477/diagnostic-value-of-magnetic-resonance-neurography-in-cervical-radiculopathy-plexus-patterns-and-peripheral-nerve-lesions
#14
Daniel Schwarz, Henrich Kele, Moritz Kronlage, Tim Godel, Tim Hilgenfeld, Martin Bendszus, Philipp Bäumer
OBJECTIVE: The aim of this study was to assess the imaging appearance and diagnostic value of plexus and peripheral nerve magnetic resonance neurography (MRN) in cervical radiculopathy. MATERIALS AND METHODS: This prospective study was approved by our institutional ethics committee and written informed consent was obtained from all participants. A total of 24 patients were included with a diagnosis of cervical radiculopathy based on clinical examination, supporting electrophysiological examinations and spinal imaging consistent with the clinical syndrome...
October 2, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28976476/comparison-of-unenhanced-t1-weighted-signal-intensities-within-the-dentate-nucleus-and-the-globus-pallidus-after-serial-applications-of-gadopentetate-dimeglumine-versus-gadobutrol-in-a-pediatric-population
#15
Diane M Renz, Stefanie Kümpel, Joachim Böttcher, Alexander Pfeil, Florian Streitparth, Matthias Waginger, Jürgen R Reichenbach, Ulf K Teichgräber, Hans-Joachim Mentzel
OBJECTIVE: The aim of this study was to evaluate and compare changes in T1-weighted signal intensity (SI) within the dentate nucleus (DN) and globus pallidus (GP) in a pediatric population after serial applications of the linear gadolinium-based magnetic resonance contrast medium gadopentetate dimeglumine and the more stable macrocyclic agent gadobutrol. MATERIALS AND METHODS: Institutional review board approval was obtained. Two similar pediatric patient cohorts who underwent at least 3 serial contrast-enhanced magnetic resonance imaging (MRI) examinations with sole application of gadopentetate dimeglumine or gadobutrol were analyzed...
October 2, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28976478/compressed-sensing-accelerated-3-dimensional-magnetic-resonance-cholangiopancreatography-application-in-suspected-pancreatic-diseases
#16
Liang Zhu, Xi Wu, Zhaoyong Sun, Zhengyu Jin, Elisabeth Weiland, Esther Raithel, Tianyi Qian, Huadan Xue
OBJECTIVES: The aims of this study were to prospectively evaluate image quality, duct visibility, and diagnostic performance in duct-related pathologies of compressed-sensing (CS) accelerated 3-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) prototype protocols and compare these with those of conventional 3D MRCP protocol in patients with suspected pancreatic diseases. MATERIAL AND METHODS: The institutional review board approved this prospective study and all patients provided written informed consent...
September 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28945655/photon-counting-ct-high-resolution-imaging-of-coronary-stents
#17
Manoj Mannil, Tilman Hickethier, Jochen von Spiczak, Matthias Baer, André Henning, Madeleine Hertel, Bernhard Schmidt, Thomas Flohr, David Maintz, Hatem Alkadhi
PURPOSE: The aim of this study was to investigate computed tomography (CT) imaging characteristics of coronary stents using a novel photon-counting detector (PCD) in comparison with a conventional energy-integrating detector (EID). MATERIALS AND METHODS: In this in vitro study, 18 different coronary stents were expanded in plastic tubes of 3 mm diameter, were filled with contrast agent (diluted to an attenuation of 250 Hounsfield units [HU] at 120 kVp), and were sealed...
September 23, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28937545/non-contrast-pseudo-continuous-arterial-spin-labeling-and-accelerated-3-dimensional-radial-acquisition-intracranial-3-dimensional-magnetic-resonance-angiography-for-the-detection-and-classification-of-intracranial-arteriovenous-shunts
#18
Tilman Schubert, Zachary Clark, Carolina Sandoval-Garcia, Ryan Zea, Oliver Wieben, Huimin Wu, Patrick A Turski, Kevin M Johnson
OBJECTIVES: The aim of this study was to assess the sensitivity and specificity of pseudo-continuous arterial spin labeling (PCASL) magnetic resonance angiography (MRA) with 3-dimensional (3D) radial acquisition for the detection of intracranial arteriovenous (AV) shunts. MATERIALS AND METHODS: A total of 32 patients who underwent PCASL-MRA, clinical magnetic resonance imaging (MRI)/MRA exam, and digital subtraction angiography (DSA) were included in this retrospective analysis...
September 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28926370/photon-counting-computed-tomography-for-vascular-imaging-of-the-head-and-neck-first-in-vivo-human-results
#19
Rolf Symons, Daniel S Reich, Mohammadhadi Bagheri, Tyler E Cork, Bernhard Krauss, Stefan Ulzheimer, Steffen Kappler, David A Bluemke, Amir Pourmorteza
PURPOSE: The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS: In this institutional review board-approved study, 16 asymptomatic subjects (7 men) provided informed consent and received both PCD and EID contrast-enhanced CT scans of the head and neck (mean age, 58 years; range, 46-75 years)...
September 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28857861/motion-corrected-real-time-cine-magnetic-resonance-imaging-of-the-heart-initial-clinical-experience
#20
Amir Ali Rahsepar, Haris Saybasili, Ahmadreza Ghasemiesfe, Ryan S Dolan, Monda L Shehata, Marcos P Botelho, Michael Markl, Bruce Spottiswoode, Jeremy D Collins, James C Carr
OBJECTIVES: Free-breathing real-time (RT) imaging can be used in patients with difficulty in breath-holding; however, RT cine imaging typically experiences poor image quality compared with segmented cine imaging because of low resolution. Here, we validate a novel unsupervised motion-corrected (MOCO) reconstruction technique for free-breathing RT cardiac images, called MOCO-RT. Motion-corrected RT uses elastic image registration to generate a single heartbeat of high-quality data from a free-breathing RT acquisition...
January 2018: Investigative Radiology
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