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Investigative Radiology

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https://www.readbyqxmd.com/read/27898603/an-ultra-high-field-study-of-cerebellar-pathology-in-early-relapsing-remitting-multiple-sclerosis-using-mp2rage
#1
Mário João Fartaria, Kieran OʼBrien, Alexandra Şorega, Guillaume Bonnier, Alexis Roche, Pavel Falkovskiy, Gunnar Krueger, Tobias Kober, Meritxell Bach Cuadra, Cristina Granziera
OBJECTIVES: The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). MATERIALS AND METHODS: Twenty early-stage relapsing-remitting MS patients underwent an MP2RAGE acquisition at 7 T magnetic resonance imaging (MRI) (images acquired at 2 different resolutions: 0.58 × 0.58 × 0.58 mm, 7T_0.58, and 0.75 × 0.75 × 0...
November 28, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27898602/novel-high-spatiotemporal-resolution-versus-standard-of-care-dynamic-contrast-enhanced-breast-mri-comparison-of-image-quality
#2
Courtney K Morrison, Leah C Henze Bancroft, Wendy B DeMartini, James H Holmes, Kang Wang, Ryan J Bosca, Frank R Korosec, Roberta M Strigel
OBJECTIVE: Currently, dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) prioritizes spatial resolution over temporal resolution given the limitations of acquisition techniques. The purpose of our intrapatient study was to assess the ability of a novel high spatial and high temporal resolution DCE breast MRI method to maintain image quality compared with the clinical standard-of-care (SOC) MRI. MATERIALS AND METHODS: Thirty patients, each demonstrating a focal area of enhancement (29 benign, 1 cancer) on their SOC MRI, consented to undergo a research DCE breast MRI on a second date...
November 28, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27875338/an-image-domain-contrast-material-extraction-method-for-dual-energy-computed-tomography
#3
Jack W Lambert, Yuxin Sun, Robert G Gould, Michael A Ohliger, Zhixi Li, Benjamin M Yeh
OBJECTIVES: Conventional material decomposition techniques for dual-energy computed tomography (CT) assume mass or volume conservation, where the CT number of each voxel is fully assigned to predefined materials. We present an image-domain contrast material extraction process (CMEP) method that preferentially extracts contrast-producing materials while leaving the remaining image intact. MATERIALS AND METHODS: Image processing freeware (Fiji) is used to perform consecutive arithmetic operations on a dual-energy ratio map to generate masks, which are then applied to the original images to generate material-specific images...
November 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861233/aortic-volumetry-at-contrast-enhanced-magnetic-resonance-angiography-feasibility-as-a-sensitive-method-for-monitoring-bicuspid-aortic-valve-aortopathy
#4
Brian Trinh, Iram Dubin, Ozair Rahman, Marcos P Ferreira Botelho, Nicholas Naro, James C Carr, Jeremy D Collins, Alex J Barker
OBJECTIVES: Bicuspid aortic valve patients can develop thoracic aortic aneurysms and therefore require serial imaging to monitor aortic growth. This study investigates the reliability of contrast-enhanced magnetic resonance angiography (CEMRA) volumetry compared with 2-dimensional diameter measurements to identify thoracic aortic aneurysm growth. MATERIALS AND METHODS: A retrospective, institutional review board-approved, and Health Insurance Portability and Accountability Act-compliant study was conducted on 20 bicuspid aortic valve patients (45 ± 8...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861232/safety-and-efficacy-of-magnetic-resonance-guided-vacuum-assisted-large-volume-breast-biopsy-mr-guided-valb
#5
Simone Schrading, Kevin Strobel, Annika Keulers, Timm Dirrichs, Christiane K Kuhl
OBJECTIVE: Magnetic resonance (MR)-guided vacuum-biopsy is technically demanding and may fail depending on target-lesion size or breast size, and location of lesions within the breast. We developed an MR-guided vacuum-assisted biopsy protocol that collects larger amounts of tissue, aiming at an at least partial or complete ablation of the target-lesion, just as it is intended during surgical (excisional) biopsy. Rationale is to avoid biopsy failures (false-negative results due to undersampling) by collecting larger amounts of tissue...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861231/wavelet-based-angiographic-reconstruction-of-computed-tomography-perfusion-data-diagnostic-value-in-cerebral-venous-sinus-thrombosis
#6
Wolfgang G Kunz, Felix Schuler, Wieland H Sommer, Matthias P Fabritius, Lukas Havla, Felix G Meinel, Maximilian F Reiser, Birgit Ertl-Wagner, Kolja M Thierfelder
OBJECTIVE: The aim of this study was to test the diagnostic value of wavelet-based angiographic reconstruction of CT perfusion data (waveletCTA) to detect cerebral venous sinus thrombosis (CVST) in patients who underwent whole-brain CT perfusion imaging (WB-CTP). MATERIALS AND METHODS: Datasets were retrospectively selected from an initial cohort of 2863 consecutive patients who had undergone multiparametric CT including WB-CTP. WaveletCTA was reconstructed from WB-CTP: the angiographic signal was generated by voxel-based wavelet transform of time attenuation curves (TACs) from WB-CTP raw data...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861230/structured-reporting-of-rectal-magnetic-resonance-imaging-in-suspected-primary-rectal-cancer-potential-benefits-for-surgical-planning-and-interdisciplinary-communication
#7
Dominik Nörenberg, Wieland H Sommer, Wolfgang Thasler, Jan DʼHaese, Markus Rentsch, Thomas Kolben, Andreas Schreyer, Carsten Rist, Maximilian Reiser, Marco Armbruster
OBJECTIVES: The aim of this study was to evaluate the effect of structured reports (SRs) in comparison to nonstructured, free-text (FT) rectal magnetic resonance imaging (MRI) reports in patients with histologically proven rectal cancer and potential effects of both types of reporting on referring surgeons' satisfaction, interdisciplinary communication, and further clinical decision making. MATERIALS AND METHODS: The institutional review board approved this retrospective study with waiver of informed consent...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861207/tailored-duration-of-contrast-material-injection-in-high-pitch-computed-tomographic-aortography-with-a-double-level-test-bolus-method
#8
Tatsuya Nishii, Yoshiaki Watanabe, Shinsuke Shimoyama, Atsushi K Kono, Keitaro Sofue, Shumpei Mori, Satoru Takahashi, Kazuro Sugimura
OBJECTIVES: To achieve the efficient usage of contrast material (CM) in high-pitch CT aortography, an appropriate duration of the CM injection is crucial. We used a modification of the double-level test bolus method for determination of proper injection duration with the aim of evaluating the image quality of tailored-duration CM injection compared with that of a fixed duration. MATERIALS AND METHODS: The institutional review board approved retrospective review of 80 consecutive subjects who had undergone high-pitch 70-kVp CT aortography with a modified double-level test bolus method...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861206/comparison-of-the-detection-rate-of-simulated-microcalcifications-in-full-field-digital-mammography-digital-breast-tomosynthesis-and-synthetically-reconstructed-2-dimensional-images-performed-with-2-different-digital-x-ray-mammography-systems
#9
Sabine Peters, Martin Hellmich, Alexander Stork, Jörn Kemper, Olga Grinstein, Michael Püsken, Leandra Stahlhut, Sonja Kinner, David Maintz, Kathrin Barbara Krug
OBJECTIVE: The aim of this study was to compare the microcalcification detectability in an anthropomorphic phantom model regarding number, size, and shape in full-field digital mammography (FFDM), synthetically reconstructed 2-dimensional (Synthetic-2D) images, and digital breast tomosynthesis (DBT) performed with 2 different x-ray mammography systems. MATERIALS AND METHODS: Simulated microcalcifications of different numbers (0 to >39), sizes (diameter, 100-800 μm), and shapes (round vs heterogeneous) were scattered by random distribution on 50 film phantoms each divided in 4 quadrants...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27861205/improved-delineation-of-pulmonary-embolism-and-venous-thrombosis-through-frequency-selective-nonlinear-blending-in-computed-tomography
#10
Malte Niklas Bongers, Georg Bier, Christopher Kloth, Christoph Schabel, Jan Fritz, Konstantin Nikolaou, Marius Horger
OBJECTIVE: The aim of this study was to test the hypothesis that a novel frequency selective nonlinear blending (NLB) algorithm increases the delineation of pulmonary embolism and venous thrombosis in portal-venous phase whole-body staging computed tomography (CT). MATERIALS AND METHODS: A cohort of 67 patients with incidental pulmonary embolism and/or venous thrombosis in contrast-enhanced oncological staging CT were retrospectively selected. Computed tomography data sets were acquired 65 to 90 seconds after intravenous iodine contrast administration using state-of-the-art multi-detector CT scanners...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27828787/speed-in-clinical-magnetic-resonance
#11
Val M Runge, Johannes K Richter, Johannes T Heverhagen
The relevant clinical accelerated magnetic resonance techniques that are available currently for routine patient examinations are reviewed, presenting and discussing the benefits therein when compared with more conventional scans. The focus is on clinical use and practicality, with the review divided into 3 sections. Improvements in 3-dimensional acquisition are first discussed, specifically controlled aliasing in parallel imaging results in higher acceleration, related radial techniques, and CAIPI-Dixon-TWIST-VIBE...
November 8, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27805917/caval-subtraction-2d-phase-contrast-mri-to-measure-total-liver-and-hepatic-arterial-blood-flow-proof-of-principle-correlation-with-portal-hypertension-severity-and-validation-in-patients-with-chronic-liver-disease
#12
Manil D Chouhan, Rajeshwar P Mookerjee, Alan Bainbridge, Shonit Punwani, Helen Jones, Nathan Davies, Simon Walker-Samuel, David Patch, Rajiv Jalan, Steve Halligan, Mark F Lythgoe, Stuart A Taylor
OBJECTIVES: Caval subtraction phase-contrast magnetic resonance imaging (PCMRI) noninvasive measurements of total liver blood flow (TLBF) and hepatic arterial (HA) flow have been validated in animal models and translated into normal volunteers, but not patients. This study aims to demonstrate its use in patients with liver cirrhosis, evaluate measurement consistency, correlate measurements with portal hypertension severity, and invasively validate TLBF measurements. MATERIALS AND METHODS: Local research ethics committee approval was obtained...
October 31, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27755154/intrathecal-contrast-enhanced-magnetic-resonance-imaging-related-brain-signal-changes-residual-gadolinium-deposition
#13
Ali Yusuf Öner, Berrak Barutcu, Şükrü Aykol, Emin Turgut Tali
OBJECTIVES: There have been recent studies evaluating brain magnetic resonance imaging changes in patients with normal renal function, after intravenous administration of gadolinium-based contrast agents (GBCAs). Their findings were supported by histological evidence as well and brought a new vision concerning what needs to be learned to provide better patient care. In this report, we aim to present brain magnetic resonance imaging changes after intrathecal administration of a linear ionic agent (gadopentetate dimeglumine)...
October 13, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27741021/left-atrial-performance-in-the-course-of-hypertrophic-cardiomyopathy-relation-to-left-ventricular-hypertrophy-and-fibrosis
#14
Johannes T Kowallick, Miguel Silva Vieira, Shelby Kutty, Joachim Lotz, Gerd Hasenfu, Amedeo Chiribiri, Andreas Schuster
OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is associated with left atrial (LA) functional abnormalities. The determinants and the degree of LA dysfunction in the course of HCM are not fully understood. We aimed to characterize LA mechanics in HCM, according to the extent of left ventricular (LV) hypertrophy and fibrosis. METHODS AND RESULTS: Seventy-three HCM patients and 23 age- and sex-matched controls underwent cardiovascular magnetic resonance imaging including late gadolinium enhancement (LGE)...
October 12, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27662577/simultaneous-multislice-diffusion-weighted-imaging-of-the-kidney-a-systematic-analysis-of-image-quality
#15
David Kenkel, Borna K Barth, Marco Piccirelli, Lukas Filli, Tim Finkenstädt, Cäcilia S Reiner, Andreas Boss
OBJECTIVES: The aims of this study were to implement a protocol for simultaneous multislice (SMS) accelerated diffusion-weighted imaging (DWI) of the kidneys and to perform a systematic analysis of image quality of the data sets. MATERIALS AND METHODS: Ten healthy subjects and 5 patients with renal masses underwent DWI of the kidney in this prospective institutional review board-approved study on a 3 T magnetic resonance scanner. Simultaneous multislice DWI echo-planar sequences (acceleration factors [AFs] 2 and 3) were compared with conventional echo-planar DWI as reference standard for each acquisition scheme...
September 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27662576/radiation-dose-comparison-between-70-kvp-and-100-kvp-with-spectral-beam-shaping-for-non-contrast-enhanced-pediatric-chest-computed-tomography-a-prospective-randomized-controlled-study
#16
Meike Weis, Thomas Henzler, John W Nance, Holger Haubenreisser, Mathias Meyer, Sonja Sudarski, Stefan O Schoenberg, K Wolfgang Neff, Claudia Hagelstein
OBJECTIVE: The aim of this prospective randomized controlled study was to compare 2 techniques for radiation dose reduction in non-contrast-enhanced pediatric chest computed tomography (CT): low peak kilovoltage imaging at 70 kVp and spectral beam shaping at 100 kVp using a dedicated tin filter (100-kVp Sn). MATERIALS AND METHODS: All chest CT examinations were performed on a third-generation dual-source CT system (SOMATOM Force; Siemens Healthineers, Germany). Fifty children (mean age, 6...
September 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27662575/hyperpolarized-129xenon-magnetic-resonance-imaging-to-quantify-regional-ventilation-differences-in-mild-to-moderate-asthma-a-prospective-comparison-between-semiautomated-ventilation-defect-percentage-calculation-and-pulmonary-function-tests
#17
Lukas Ebner, Mu He, Rohan S Virgincar, Timothy Heacock, Suryanarayanan S Kaushik, Matthew S Freemann, H Page McAdams, Monica Kraft, Bastiaan Driehuys
OBJECTIVES: The aim of this study was to investigate ventilation in mild to moderate asthmatic patients and age-matched controls using hyperpolarized (HP) Xenon magnetic resonance imaging (MRI) and correlate findings with pulmonary function tests (PFTs). MATERIALS AND METHODS: This single-center, Health Insurance Portability and Accountability Act-compliant prospective study was approved by our institutional review board. Thirty subjects (10 young asthmatic patients, 26 ± 6 years; 3 males, 7 females; 10 older asthmatic patients, 64 ± 6 years; 3 males, 7 females; 10 healthy controls) were enrolled...
September 22, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27654582/ultra-low-dose-ultrasound-molecular-imaging-for-the-detection-of-angiogenesis-in-a-mouse-murine-tumor-model-how-little-can-we-see
#18
Shiying Wang, Elizabeth B Herbst, F William Mauldin, Galina B Diakova, Alexander L Klibanov, John A Hossack
OBJECTIVES: The objective of this study was to evaluate the minimum microbubble dose for ultrasound molecular imaging to achieve statistically significant detection of angiogenesis in a mouse model. MATERIALS AND METHODS: The preburst minus postburst method was implemented on a Verasonics ultrasound research scanner using a multiframe compounding pulse inversion imaging sequence. Biotinylated lipid (distearoyl phosphatidylcholine-based) microbubbles that were conjugated with antivascular endothelial growth factor 2 (VEGFR2) antibody (MBVEGFR2) or isotype control antibody (MBControl) were injected into mice carrying adenocarcinoma xenografts...
December 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27115702/a-proposed-computed-tomography-contrast-agent-using-carboxybetaine-zwitterionic-tantalum-oxide-nanoparticles-imaging-biological-and-physicochemical-performance
#19
Paul F FitzGerald, Matthew D Butts, Jeannette C Roberts, Robert E Colborn, Andrew S Torres, Brian D Lee, Benjamin M Yeh, Peter J Bonitatibus
OBJECTIVES: The aim of this study was to produce and evaluate a proposed computed tomography (CT) contrast agent based on carboxybetaine zwitterionic (CZ)-coated soluble tantalum oxide (TaO) nanoparticles (NPs). We chose tantalum to provide superior imaging performance compared with current iodine-based clinical CT contrast agents. We developed the CZ coating to provide biological and physical performance similar to that of current iodinated contrast agents. In addition, the aim of this study was to evaluate the imaging, biological, and physicochemical performance of this proposed contrast agent compared with clinically used iodinated agents...
December 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27760058/time-of-arrival-parametric-maps-and-virtual-bolus-images-derived-from-contrast-enhanced-time-resolved-radial-magnetic-resonance-angiography-improve-the-display-of-brain-arteriovenous-malformation-vascular-anatomy
#20
Tilman Schubert, Yijing Wu, Kevin M Johnson, Oliver Wieben, Jane Maksimovic, Charles Mistretta, Patrick Turski
OBJECTIVES: Time-of-arrival (TOA) maps can be derived from high-resolution 4-dimensional (4D) contrast-enhanced magnetic resonance angiography (MRA) data sets to provide a quantitative description of contrast material arrival time in each voxel. This information can further be processed to create a compressed time evolution curve that virtually shortens the contrast bolus (virtual bolus [VB]). The purpose of this project was to determine whether TOA-enhanced 4D MRA and/or VB imaging improve the display of contrast kinetics in patients with vascular disease...
November 2016: Investigative Radiology
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