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International Archives of Allergy and Immunology

Pelin Kuteyla Can, Pırıl Etikan, Utkan Kızıltaç, Kübra Kızıltaç, Ralfi Singer, Emek Kocaturk
BACKGROUND: Fric test is a useful tool for the diagnosis and threshold testing for symptomatic dermographism. When threshold testing is not available, Urticaria Control Test (UCT) and Dermatology Life Quality Index (DLQI) might be used to assess disease control and quality of life (QoL) impairment, respectively. OBJECTIVES: In this study, we aimed to describe a new scoring system for the Fric test and evaluate the correlations of Fric scores with UCT, DLQI, and other disease activity assessment scores...
October 4, 2018: International Archives of Allergy and Immunology
Nihal Mete Gökmen, Okan Gülbahar, Hüseyin Onay, Zeynep Peker Koc, Semiha Özgül, Timur Köse, Aslı Gelincik, Suna Büyüköztürk, Aytül Zerrin Sin
BACKGROUND: How genotype affects phenotype in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) has not been totally clarified. In this study, we investigated the relationship between different types of mutations and various phenotypic characteristics. METHODS: Clinical data from 81 patients from 47 families were recorded. Complement proteins were analyzed from 61 untreated patients. The coding exons and the exon-intron boundaries of the SERPING1 gene were sequenced, and deletion/duplication analysis with multiple ligation dependent probe amplification was performed...
October 2, 2018: International Archives of Allergy and Immunology
Simona Barni, Francesca Mori, Alessandra Piccorossi, Lucrezia Sarti, Neri Pucci, Maria Maresca, Mattia Giovannini, Giulia Liccioli, Elio Novembre
BACKGROUND: Hazelnut allergy (HA) is one of the more common food allergies (FAs) in Europe with a prevalence of 0.2%. The gold standard for diagnosing FA is oral food challenge (OFC) with the culprit food. Another purpose of OFC is to identify the "threshold level" of food as the dose that elicits symptoms. In this way it is possible to avoid a strict elimination diet and to determine the minimal quantity of the culprit food tolerated by the patient. OBJECTIVE: The aim of our study was to assess the efficacy and tolerability of hazelnut low-dose OFC (H-LDOFC) in children with HA...
September 27, 2018: International Archives of Allergy and Immunology
Debarati Dey, Priti Mondal, Arghya Laha, Tania Sarkar, Saibal Moitra, Srijit Bhattacharyya, Goutam Kumar Saha, Sanjoy Podder
BACKGROUND: Aeroallergen sensitization is increasing worldwide. The optimal management of allergic disease requires the identification of the allergic sensitivities of the patient. Complete data of offending aeroallergens are scant from West Bengal, India. Hence, we employed a retrospective analysis of an atopic population of West Bengal to investigate the rate of sensitivity toward common aeroallergens including pollens, molds and house dust mites. OBJECTIVES: The aim of the present study was to evaluate the profile of skin prick test (SPT) reactivity of an atopic population of eastern India...
September 26, 2018: International Archives of Allergy and Immunology
Sara Manti, Carmelo Salpietro, Caterina Cuppari
The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate...
September 25, 2018: International Archives of Allergy and Immunology
Monica Andreassen, Knut Rudi, Inga Leena Angell, Hubert Dirven, Unni C Nygaard
BACKGROUND: The incidence of food allergies in western countries has increased in recent decades. OBJECTIVES: To study the association between gut bacterial microbiota composition, short-chain fatty acids (SCFAs) and food allergy in a mouse model. METHODS: After oral immunizations with the human food allergen lupine with the adjuvant cholera toxin (CT) (or buffer in controls), sensitization and anaphylactic responses were determined. Gastrointestinal content was collected from the distal ileum, cecum, colon, and fecal pellets, and the bacterial diversity and composition was determined by deep sequencing of the 16S rRNA gene...
September 21, 2018: International Archives of Allergy and Immunology
Mohamed M Saleh, Susann Forkel, Michael P Schön, Thomas Fuchs, Timo Buhl
BACKGROUND: Natural rubber latex (NRL) allergy is commonly diagnosed according to medical history, skin allergy tests, and serological analyses. However, skin tests are increasingly being abandoned because of (i) their time-consuming nature, (ii) latex preparations for skin tests being not commercially available, and (iii) the use of in-house prepared test solutions is becoming ever more difficult due to increasing regulatory hurdles. In this light, we have evaluated differences in the profiles of current and former patients with suspected latex allergy...
September 13, 2018: International Archives of Allergy and Immunology
Danilo Villalta, Enrico Scala, Gianni Mistrello, Stefano Amato, Riccardo Asero
Seed storage proteins are extremely stable allergens in nuts, seeds, and legumes and are responsible for the most severe allergic reactions to these foods. The cross-reactivity between seed storage proteins from different sources has not been studied at a molecular level so far. This study aimed to ascertain the cross-reactivity between walnut and hazelnut seed storage proteins using recombinant allergens. Sera from 13 consecutive patients with severe primary walnut and/or hazelnut allergy and hypersensitive to both nuts were studied...
September 13, 2018: International Archives of Allergy and Immunology
Shuichi Suzuki, Eduardo Campos-Alberto, Yoshinori Morita, Makoto Yamaguchi, Takayuki Toshimitsu, Katsunori Kimura, Shuji Ikegami, Toshiyuki Katsuki, Yoichi Kohno, Naoki Shimojo
BACKGROUND: Altered regulatory immune responses to microbial stimuli and intestinal colonization of beneficial bacteria early in life may contribute to the development of allergic diseases (e.g., atopic dermatitis [AD]). However, few reports have investigated these factors simultaneously. The purpose of this study was to analyze neonatal immune responses to microbial stimuli as well as intestinal colonization of beneficial bacteria, in relation to the development of AD in a birth cohort...
September 11, 2018: International Archives of Allergy and Immunology
Bandar Al-Saud, Sigurveig T Sigurdardóttir
BACKGROUND: The timing of the introduction of egg to an infant's diet is of current interest, as new evidence raises questions regarding the benefit of delaying egg introduction. The objective of this study was to systematically review the existing literature regarding the effect of the early introduction of egg on the development of egg allergy. METHODS: Literature searches were conducted in MEDLINE, EMBASE, and CENTRAL, and trial protocols were searched in Meta Register and OpenGREY...
September 5, 2018: International Archives of Allergy and Immunology
Oliviero Quercia, Vittoria Cova, Matteo Martini, Gabriele Cortellini, Francesco Murzilli, Donatella Bignardi, Marcello Cilia, Alessandro Scarpa, Maria Beatrice Bilò
Cross-reactions between Polistes dominula and Vespula species are common in southern Europe. Currently, only CAP-inhibition demonstrates high accuracy in identifying genuine sensitizations, but this method is time-consuming and expensive, so a new approach is required. This study investigates skin tests, molecular diagnostics, total IgE (tIgE), and the Ves v 5/Pol d 5 (or vice versa) ratio. The ratio generated low-accuracy results and poor agreement with CAP-inhibition, and we did not find any agreement between CAP-inhibition test and double values of Ves v 5/Pol d 5...
September 3, 2018: International Archives of Allergy and Immunology
Carmen Oeo-Santos, Salvador Mas, Joaquín Quiralte, Carlos Colás, Miguel Blanca, Javier Fernández, Francisco Feo Brito, Mayte Villalba, Rodrigo Barderas
BACKGROUND: Cross-reactivity reactions between allergenic polygalacturonases (PGs) from different biological sources, especially foods and pollens from the Oleaceae family, have been described using Salsola kali PG (Sal k 6). No PG from olive pollen has been characterized to date, hampering further knowledge about cross-reactions through PGs. OBJECTIVES: The aim of this work was to determine the potential allergenicity of the PG from olive pollen and clarify its role in cross-reactivity...
August 31, 2018: International Archives of Allergy and Immunology
Alireza S Nejad, Donald W MacGlashan
BACKGROUND: The characteristics of the aggregation reaction that follows allergen binding to cell surface IgE on basophils and mast cells depend on a variety of factors that include the density of IgE and the affinity of the allergen for IgE. For simple bivalent stimuli, one prediction is that the location of the optimum for aggregation is not dependent on IgE density, only the affinity for IgE. However, this behavior does not occur for stimulation with an anti-IgE antibody (Ab) during the treatment of patients with omalizumab...
August 27, 2018: International Archives of Allergy and Immunology
Shuguang Han, Chenhui Ma, Liang Bao, Lei Lv, Mao Huang
BACKGROUND: The prevalence of allergic asthma has increased dramatically. Previous studies have found that the microRNA 146a (miR-146a) expression in asthma inhibits cell proliferation and promotes apoptosis of bronchial smooth muscle cells. We aimed to investigate the effect of miR-146a mimics on ovalbumin (OVA)-induced asthma in a mouse model. METHODS: Inflammatory cell infiltration in bronchoalveolar lavage fluid (BALF) was measured by flow cytometry. Levels of OVA-specific immunoglobulin E (IgE) in serum and cytokines in BALF were examined by enzyme-linked immunosorbent assay...
August 22, 2018: International Archives of Allergy and Immunology
Chisato Inuo, Kenichi Tanaka, Satoko Suzuki, Yoichi Nakajima, Kazuo Yamawaki, Ikuya Tsuge, Atsuo Urisu, Yasuto Kondo
BACKGROUND: Partially hydrolyzed cow's milk protein-based formula (pHF) possesses low allergenicity. Here, we investigate the safety and efficacy of oral immunotherapy using pHF for children with cow's milk protein allergy (CMPA). OBJECTIVES: A randomized, double-blind, controlled single-center trial was conducted to evaluate the efficacy and safety of pHF oral immunotherapy in children with CMPA. METHODS: Participants were randomized into double-blind pHF-pHF and extensively hydrolyzed cow's milk protein-based formula (eHF)-pHF groups...
August 22, 2018: International Archives of Allergy and Immunology
Emek Kocatürk, Gustavo Deza, Kübra Kızıltaç, Ana M Giménez-Arnau
The recommended dose of omalizumab for the treatment of chronic spontaneous urticaria (CSU) is 300 mg every 4 weeks, but there is no recommendation for patients who do not benefit from this dose. Our aim is to present the experiences on the use of doses of omalizumab higher than those recommended for CSU patients and to propose a protocol for updosing. This was a retrospective analysis of patients treated with omalizumab for CSU from 2 urticaria centers in Istanbul and Barcelona. The weekly urticaria activity score and/or the Urticaria Control Test (UCT) were used to monitor response...
August 21, 2018: International Archives of Allergy and Immunology
Chang Hoon Han, Seung Jun Kim, Jae Ho Chung
OBJECTIVES: We explored the association between asthma severity and lower urinary tract symptoms (LUTS) using the International Prostate Symptom Score in a population-based study of males (aged ≥19 years) and evaluated voiding and urine storage symptoms. METHODS: This was a cross-sectional study of 101,848 males, 2,544 of whom had asthma, who participated in the 2011 Korean Community Health Survey. All subjects were assessed in terms of sociodemographic data, pre-existing conditions, and the presence of LUTS...
August 21, 2018: International Archives of Allergy and Immunology
Steven L Staal, Sarika K L Hogendoorn, Sophie A Voets, Rebecca C Tepper, Mirte Veenstra, Ivo I de Vos, Koen C van Son, Jari K Gool, Antonia C Paramitha, Kevin Aristyo, Ardy Wildan, Chici Pratiwi, Ronald van Ree, Maria Yazdanbakhsh, Taniawati Supali, Yenny Djuardi, Lucja A Labuda, Dicky L Tahapary, Erliyani Sartono
BACKGROUND: In many rural areas of tropical countries such as Indonesia, the prevalence of soil-transmitted helminths (STH) infections remains high. At the same time, the burden of allergic disorders in such rural areas is reported to be low and inversely associated with helminth infections. To reduce the morbidity and transmission of helminth infections, the world health organization recommends preventive treatment of school children by providing mass drug administration (MDA) with albendazole...
August 21, 2018: International Archives of Allergy and Immunology
Kashinath Bhattacharya, Gaurab Sircar, Angira Dasgupta, Swati Gupta Bhattacharya
The growing prevalence of allergy and asthma in India has become a major health concern with symptoms ranging from mild rhinitis to severe asthma and even life-threatening anaphylaxis. The "allergen repertoire" of this subcontinent is highly diverse due to the varied climate, flora, and food habits. The proper identification, purification, and molecular characterization of allergy-eliciting molecules are essential in order to facilitate an accurate diagnosis and to design immunotherapeutic vaccines...
July 27, 2018: International Archives of Allergy and Immunology
Lyudmila V Savvateeva, Svetlana I Erdes, Anton S Antishin, Andrey A Zamyatnin
Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development...
July 27, 2018: International Archives of Allergy and Immunology
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