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International Archives of Allergy and Immunology

Annabelle M Watts, Nicholas P West, Allan W Cripps, Pete K Smith, Amanda J Cox
BACKGROUND: Investigations of gene expression in allergic rhinitis (AR) typically rely on invasive nasal biopsies (site of inflammation) or blood samples (systemic immunity) to obtain sufficient genetic material for analysis. New methodologies to circumvent the need for invasive sample collection offer promise to further the understanding of local immune mechanisms relevant in AR. METHODS: A within-subject design was employed to compare immune gene expression profiles obtained from nasal washing/brushing and whole blood samples collected during peak pollen season...
June 19, 2018: International Archives of Allergy and Immunology
Marcello Albanesi, Alessandro Sinisi, Flavia Frisenda, Danilo Di Bona, Maria Filomena Caiaffa, Luigi Macchia
No abstract text is available yet for this article.
June 19, 2018: International Archives of Allergy and Immunology
Inês Mota, Ângela Gaspar, Mário Morais-Almeida
BACKGROUND: Perioperative use of cefazolin has been associated with severe allergic reactions, and patients are usually labelled as allergic to penicillin afterwards. The aim of our study was to describe a group of patients with immediate reactions to cefazolin, with proven selective hypersensitivity reactions. METHODS: Systematic review of all patients followed at our drug centre with cefazolin-related reactions, between January 2012 and December 2016. All patients were investigated according to the European Network for Drug Allergy (ENDA) recommendations through skin testing (major and minor penicillin determinants, penicillin, amoxicillin, cefazolin, cefuroxime and ceftriaxone) and oral challenges tests...
June 18, 2018: International Archives of Allergy and Immunology
Bogusław Nedoszytko, Magdalena Lange, Joanna Renke, Marek Niedoszytko, Monika Zabłotna, Jolanta Gleń, Roman Nowicki
BACKGROUND: Data on the genetic predisposition to mastocytosis are scarce. The aim of this work was to study the association of single nucleotide polymorphisms of Toll-like receptor (TLR)-2, TLR-4, and TLR-9 genes in Polish patients with mastocytosis. OBJECTIVES: The study comprised 137 patients with mastocytosis (102 cutaneous [60 children and 42 adults] and 35 systemic cases); 171 disease-free individuals were used as controls. METHOD: The frequency of polymorphisms R753Q (rs5743708) of TLR-2, 896 A>G (rs496790) of TLR-4, and -1237C>T (rs5743836) of TLR-9 genes were determined with the use of the amplification refractory mutation system polymerase chain reaction method...
June 15, 2018: International Archives of Allergy and Immunology
Paola Conigliaro, Paola Triggianese, Gianluca Draghessi, Claudia Canofari, Gianluca Aloe, Maria Sole Chimenti, Claudia Valeri, Carlo Nucci, Roberto Perricone, Massimo Cesareo
BACKGROUND: Retinal involvement in systemic lupus erythematosus (SLE) and Sjögren syndrome (SS) may be subclinical and thus underdiagnosed. OBJECTIVES: We aimed at evaluating morphological and functional visual abnormalities in a cohort of SLE and SS patients in the absence of an overt clinical visual impairment. We also investigated potential associations between retinal disorders and disease activity, organ involvement, and treatment with steroid and/or hydroxychloroquine...
June 14, 2018: International Archives of Allergy and Immunology
Lin Lin, Zheng Chen, Xinyue Tang, Fei Dai, Jinjin Wei, Guangbin Sun
BACKGROUND: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant and activator that is synthesized not only in inflammatory cells but also in bronchial epithelial cells. The purpose of this study is to clarify whether 5-oxo-ETE can promote the production of eosinophil cation protein (ECP) by eosinophils in nasal polyps (NP) in vitro, and whether normal nasal epithelial cells can produce this lipid mediator in response to oxidative stress. MATERIALS AND METHODS: Nasal biopsy samples were obtained from normal subjects or subjects with chronic rhinosinusitis with NP...
June 13, 2018: International Archives of Allergy and Immunology
Petr Heneberg, Lucie Kocková, Marie Čecháková, Pavlína Daňková, Marie Černá
BACKGROUND: A portion of adults with humoral immune changes have clinical diabetes that is initially not insulin-requiring (latent autoimmune diabetes of the adult, LADA). One of the genes strongly associated with autoimmune diabetes is PTPN22. We hypothesized that the manifestation and clinical features of LADA are linked to functional variants of PTPN22. METHODS: We genotyped allelic frequencies of 1 protective and 3 risk-associated PTPN22 variants in 156 Czech LADA patients, 194 type 2 diabetes mellitus patients with LADA-like progression to insulinotherapy and 324 type 1 diabetes mellitus patients, and subsequently examined the associations of PTPN22 variants with the expression of autoantibodies and other clinical features of LADA...
June 12, 2018: International Archives of Allergy and Immunology
Nora Nilsson, Caroline Nilsson, Helena Ekoff, Sandra Wieser-Pahr, Magnus P Borres, Rudolf Valenta, Gunilla Hedlin, Sigrid Sjölander
BACKGROUND: Specific immunoglobulin E (IgE) sensitization to wheat is more common than a doctor's confirmed wheat allergy and is also frequently observed in grass pollen-allergic patients (pollinosis patients). Thus, the objective of this study was to investigate the level and feature of serological IgE cross-reactivity between grass pollen and wheat in a cohort of pollinosis subjects with no diagnosis of wheat allergy. METHODS: Seventy-two children, aged 5-17 years, with a doctor's diagnosis of pollinosis, IgE towards grass pollen, and currently eating wheat were recruited...
June 12, 2018: International Archives of Allergy and Immunology
Mats W Johansson, Elizabeth A Kelly, Christopher L Nguyen, Nizar N Jarjour, Bruce S Bochner
BACKGROUND: Siglec-8 is present at a high level on human blood eosinophils and low level on blood basophils. Engagement of Siglec-8 on blood eosinophils causes its internalization and results in death. Siglec-8 is a potential therapeutic target in eosinophilic asthma. OBJECTIVES: The aim of this study was to determine Siglec-8 levels on eosinophils and basophils recruited during lung inflammation. METHOD: We analyzed surface Siglec-8 by flow cytometry on cells obtained by bronchoalveolar lavage (BAL) 48 h after segmental lung allergen challenge of human subjects with mild allergic asthma and used confocal microscopy to compare Siglec-8 distribution on BAL and blood eosinophils...
June 7, 2018: International Archives of Allergy and Immunology
Beatriz Cabanillas, Soheila J Maleki, Hsiaopo Cheng, Natalija Novak
Roasting has been implicated in the increase of peanut allergenicity due to the chemical reactions that occur during the process. However, this increase is not fully understood, and little information is available regarding the role of roasted peanut allergens in the initial phase of allergy, where dendritic cells (DCs) play a key role. We sought to analyze differences in the internalization of Ara h 3 from raw and roasted peanut by immature monocyte-derived DCs (MDDCs) and the implication of the mannose receptor in the uptake...
June 7, 2018: International Archives of Allergy and Immunology
Xia Xi, Jing-Mei Liu, Jun-Ying Guo
BACKGROUND: The balance between T helper 17 (Th17) and regulatory T cells (Treg) is a new paradigm in asthma pathogenesis, but no therapeutic targets could modulate the Th17/Treg balance specifically for asthma. Since previous studies have shown the programmed cell death-1(PD-1)/PD-ligand 1 (PD-L1) pathway is critical to immune homeostasis in this disease, we hypothesized that the PD-1/PD-L1 pathway might be involved in the regulation of Treg/Th17 imbalance in asthmatic children. METHODS: The percentage of Treg and Th17 cells and the expression of PD-1 and PD-L1 were detected by flow cytometry in children with asthma and healthy controls...
June 6, 2018: International Archives of Allergy and Immunology
Jun Kido, Natsuko Nishi, Tomoaki Matsumoto
BACKGROUND: Many researchers have made efforts to develop diagnostic tools for predicting the outcome of oral food challenges (OFCs). The aim of this study was to assess the diagnostic value of the skin prick test (SPT) and blood-specific IgE concentrations based on the outcome of the OFCs for heated and raw hen egg. METHODS: This study included 103 children with suspected hen egg allergy (HEA; median age 23 months, range 10-155; 72 boys, 31 girls). Forty-three patients were diagnosed with HEA by OFC...
June 6, 2018: International Archives of Allergy and Immunology
Tasuku Kawano, Ryusuke Ouchi, Takahiro Ishigaki, Chiaki Masuda, Tomomitsu Miyasaka, Yuichi Ohkawara, Nobuo Ohta, Motoaki Takayanagi, Tomoko Takahashi, Isao Ohno
BACKGROUND: Bronchial asthma is characterized by type 2 T helper (Th2) cell inflammation, essentially due to a breakdown of immune tolerance to harmless environmental allergens. Etiologically, experiences of psychological stress can be associated with a heightened prevalence of asthma. However, the mechanisms underlying stress-related asthma development are unclear. In this study, we examined whether psychological stress increases susceptibility to allergic asthma by downregulating immune tolerance...
June 6, 2018: International Archives of Allergy and Immunology
De Yun Wang, Sang-Heon Cho, Horng-Chyuan Lin, Aloke Gopal Ghoshal, Abdul Razak Bin Abdul Muttalif, Sanguansak Thanaviratananich, Kaan Tunceli, Eduardo Urdaneta, Dongmu Zhang, Rab Faruqi
BACKGROUND: Allergic rhinitis (AR), asthma, chronic obstructive pulmonary disease (COPD), and rhinosinusitis are common and little studied in the Asia-Pacific region. OBJECTIVES: We sought to investigate real-world practice patterns for these respiratory diseases in India, Korea, Malaysia, Singapore, Taiwan, and Thailand. METHODS: This cross-sectional observational study enrolled adults (age ≥18 years) presenting to general practitioners (GP) or specialists for physician-diagnosed AR, asthma, COPD, or rhinosinusitis...
June 6, 2018: International Archives of Allergy and Immunology
Yumi Koike, Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Kiyotaka Ohtani, Takanori Imai, Motohiro Ebisawa
BACKGROUND: Wheat allergy is the third most common food allergy that develops during infancy in Japan. To identify factors associated with persistent wheat allergy, we assessed the rate of tolerance acquisition among Japanese children aged less than 6 years with an immediate-type wheat allergy using the oral food challenge (OFC) method. METHODS: This retrospective cohort study included 83 children (born in 2005-2006) who had a history of immediate-type allergic reaction to wheat and were followed until 6 years of age...
June 5, 2018: International Archives of Allergy and Immunology
Sarah Micozzi, Sonsoles Infante, Victoria Fuentes-Aparicio, Alberto Álvarez-Perea, Lydia Zapatero
INTRODUCTION: Celiac disease and wheat allergy (WA) are infrequent diseases in the general population, and a combination of the 2 is particularly rare. Celiac disease occurs in around 1% of the general population and WA in around 1% of all children. CASE REPORT: We report 2 patients with celiac disease and a gluten-free diet who developed WA consistent in anaphylaxis and an eyelid angioedema, respectively, through accidental wheat exposure. A serum study and an intestinal biopsy confirmed celiac disease...
May 30, 2018: International Archives of Allergy and Immunology
Akihiro Maeta, Marin Matsushima, Risako Katahira, Natsumi Sakamoto, Kyoko Takahashi
BACKGROUND: The objective of this study was to determine the required concentration of egg white (EW) in the diet to induce oral desensitization and/or immune tolerance within 4 weeks of oral immunotherapy (OIT) in an EW allergic mouse model. METHODS: Female BALB/c mice were systemically sensitized to EW by intraperitoneal injections and subsequently subjected to oral allergen gavage. Sensitized mice were provided 4 weeks of OIT by supplementing with 0 (non-OIT), 0...
May 30, 2018: International Archives of Allergy and Immunology
Kuan-Wei Chen, Laura Marusciac, Paul Tudor Tamas, Rudolf Valenta, Carmen Panaitescu
Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen...
May 22, 2018: International Archives of Allergy and Immunology
Bernardo Sousa-Pinto, Luís Araújo, Alberto Freitas, Luís Delgado
BACKGROUND: Beta-lactam allergy is overdiagnosed. Diagnosis of penicillin allergy has been associated with a greater use of hospital resources and an increased risk of antibiotic-resistant infections, although this issue remains poorly studied in children. We aimed to compare patient characteristics and use of hospital resources in hospitalized children with and without a record of penicillin allergy. METHODS: We identified all hospitalizations in children labelled as being allergic to penicillin in a database containing all hospitalizations in Portuguese public hospitals between 2000 and 2014, and compared these with a similar number of age-, sex-, and main diagnosis-matched hospitalizations without a penicillin allergy label...
May 22, 2018: International Archives of Allergy and Immunology
Cheol Hong Kim, Ju Suk Lee
BACKGROUND: The association between smoking and asthma remains controversial. In our previous study, we were not able to show an association between asthma and smoking in Korean adults. One Korean study demonstrated underreporting of smoking history by female adults. The aim of the present study was to investigate the effects of hidden female smoking on the association between asthma and smoking in Korean adults. METHODS: Data were acquired from 23,483 men and women aged ≥19 years who participated in the Korean National Health and Nutrition Examination Surveys (KNHANES)...
May 22, 2018: International Archives of Allergy and Immunology
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