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International Archives of Allergy and Immunology

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https://www.readbyqxmd.com/read/28505618/use-of-epinephrine-in-patients-with-drug-induced-anaphylaxis-an-analysis-of-the-beijing-pharmacovigilance-database
#1
Tiansheng Wang, Xiang Ma, Yan Xing, Shusen Sun, Hua Zhang, Til Stürmer, Bin Wang, Xiaotong Li, Huilin Tang, Ligong Jiao, Suodi Zhai
BACKGROUND: Few studies assessing the use of epinephrine in drug-induced anaphylaxis (DIA) in the hospital setting are available. We utilized the Beijing Pharmacovigilance Database (BPD) to evaluate the appropriateness of epinephrine for DIA management. METHODS: DIA cases collected in the BPD from January 2004 to December 2014 were adjudicated and analyzed for demographics, causative drugs, clinical signs, outcomes, initial treatment, route, dosing, and cardiovascular adverse events (CAE) of epinephrine...
May 16, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28494467/expression-and-characterization-of-functional-recombinant-bet-v-1-0101-in-the-chloroplast-of-chlamydomonas-reinhardtii
#2
Sonja Hirschl, Claudia Ralser, Claudia Asam, Alessandro Gangitano, Sara Huber, Christof Ebner, Barbara Bohle, Martin Wolf, Peter Briza, Fatima Ferreira, Christoph Griesbeck, Michael Wallner
BACKGROUND: Allergen immunotherapy (AIT) still plays a minor role in the treatment of allergic diseases. To improve the acceptance of AIT by allergic patients, the treatment has to become more convenient and efficacious. One possibility is the oral application of allergens or derivatives thereof. Therefore, we sought to produce a recombinant allergen in the green alga Chlamydomonas reinhardtii as a novel production platform. METHODS: The major birch pollen allergen Bet v 1 was selected as candidate molecule, and a codon-optimized gene was synthesized and stably integrated into the microalga C...
May 12, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28494455/the-clinical-impact-of-bet-v-6-in-birch-pollen-sensitized-patients
#3
Donata Gellrich, Katharina Eder, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Bet v 6, a minor birch pollen allergen, is commercially available for allergen-specific IgE antibody testing. However, there is hardly any literature on the clinical impact of Bet v 6. The aim of the present study was to analyze if testing specific IgE against Bet v 6 can add valuable benefit to the standard diagnostics of birch pollen-sensitized patients, especially in patients with unknown sensitization-eliciting allergens. METHODS: Birch pollen-sensitized patients with missing IgE reactivity against Bet v 1, 2, and 4 were tested for specific IgE antibodies against Bet v 6...
May 12, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28486236/human-invariant-natural-killer-t-cells-respond-to-antigen-presenting-cells-exposed-to-lipids-from-olea-europaea-pollen
#4
Beatriz Abos Gracia, Juan López Relaño, Ana Revilla, Lourdes Castro, Mayte Villalba, Beatriz Martín Adrados, Jose Ramon Regueiro, Edgar Fernández-Malavé, Eduardo Martínez Naves, Manuel Gómez Del Moral
BACKGROUND: Allergic sensitization might be influenced by the lipids present in allergens, which can be recognized by natural killer T (NKT) cells on antigen-presenting cells (APCs). The aim of this study was to analyze the effect of olive pollen lipids in human APCs, including monocytes as well as monocyte-derived macrophages (Mϕ) and dendritic cells (DCs). METHODS: Lipids were extracted from olive (Olea europaea) pollen grains. Invariant (i)NKT cells, monocytes, Mϕ, and DCs were obtained from buffy coats of healthy blood donors, and their cell phenotype was determined by flow cytometry...
May 10, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28482341/indigo-naturalis-ameliorates-oxazolone-induced-dermatitis-but-aggravates-colitis-by-changing-the-composition-of-gut-microflora
#5
Soichiro Adachi, Namiko Hoshi, Jun Inoue, Eiichiro Yasutomi, Takafumi Otsuka, Ramesh Dhakhwa, Zi Wang, Yuna Koo, Toshihiro Takamatsu, Yuriko Matsumura, Haruka Yamairi, Daisuke Watanabe, Makoto Ooi, Toshihito Tanahashi, Shin Nishiumi, Masaru Yoshida, Takeshi Azuma
BACKGROUND: Indigo naturalis (IND) is an herbal medicine that has been used as an anti-inflammatory agent to treat diseases including dermatitis and inflammatory bowel disease in China. However, the mechanism by which IND exerts its immunomodulatory effect is not well understood. METHODS: A murine model of dermatitis and inflammatory bowel disease, both induced by oxazolone (OXA), was treated with IND. The severity of dermatitis was evaluated based on ear thickness measurements and histological scoring...
May 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28467993/recombinant-allergens-in-structural-biology-diagnosis-and-immunotherapy
#6
Angelika Tscheppe, Heimo Breiteneder
The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible...
May 4, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28456812/comparison-of-the-performance-of-skin-prick-immunocap-and-isac-tests-in-the-diagnosis-of-patients-with-allergy
#7
Rebecca L M Griffiths, Tariq El-Shanawany, Stephen R A Jolles, Clive Selwood, Adrian G Heaps, Emily M Carne, Paul E Williams
BACKGROUND: Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively. The immuno-solid phase allergen chip (ISAC) enables testing for specific IgE against multiple allergen components in a multiplex assay. METHODS: We retrospectively analysed clinic letters, case notes, and laboratory results of 118 patients attending the National Adult Allergy Service at the University Hospital of Wales who presented diagnostic difficulty, to evaluate which testing strategy (SPT, ImmunoCAP, or ISAC) was the most appropriate to use to confirm the diagnosis in these complex patients, evaluated in a "real-life" clinical service setting...
April 29, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28456806/navigating-through-the-jungle-of-allergens-features-and-applications-of-allergen-databases
#8
Christian Radauer
The increasing number of available data on allergenic proteins demanded the establishment of structured, freely accessible allergen databases. In this review article, features and applications of 6 of the most widely used allergen databases are discussed. The WHO/IUIS Allergen Nomenclature Database is the official resource of allergen designations. Allergome is the most comprehensive collection of data on allergens and allergen sources. AllergenOnline is aimed at providing a peer-reviewed database of allergen sequences for prediction of allergenicity of proteins, such as those planned to be inserted into genetically modified crops...
April 29, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28456805/allergens-of-blomia-tropicalis-an-overview-of-recombinant-molecules
#9
Eduardo Santos da Silva, Claudia Asam, Peter Lackner, Heidi Hofer, Michael Wallner, Carina Silva Pinheiro, Neuza Maria Alcântara-Neves, Fatima Ferreira
Allergic diseases are considered a major problem for healthcare systems in both developed and developing countries. House dust mites are well-known triggers of allergic manifestations. While the Dermatophagoides genus is widely distributed globally, Blomia tropicalis is the most prominent mite species in the tropical and subtropical regions of the world. Over the last decades, an increase in sensitization rates to B. tropicalis has been reported, leading to increased research efforts on Blomia allergens. In fact, 8 new allergens have been identified and characterized to different degrees...
April 29, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28456804/climate-and-allergic-sensitization-to-airborne-allergens-in-the-general-population-data-from-the-french-six-cities-study
#10
Denis Charpin, Myriam Ramadour, François Lavaud, Chantal Raherison, Denis Caillaud, Frederic de Blay, Gabrielle Pauli, Isabella Annesi-Maesano
BACKGROUND: The results of international epidemiological surveys show large geographical variations in skin test reactivity but do not provide a rationale for such variations. OBJECTIVE: To assess the relationship between climate and allergic sensitization in schoolchildren. METHODS: In the present study, we analyzed data from a multicenter, epidemiological survey that included 6,461 schoolchildren, aged 9-11 years, living in 6 French cities scattered around France...
April 29, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28456795/sex-related-allergic-rhinitis-prevalence-switch-from-childhood-to-adulthood-a-systematic-review-and-meta-analysis
#11
Mariona Pinart, Theresa Keller, Andreas Reich, Matthias Fröhlich, Báltica Cabieses, Cynthia Hohmann, Dirkje S Postma, Jean Bousquet, Josep M Antó, Thomas Keil
BACKGROUND: A sex-related switch in the prevalence of asthma from childhood (male predominance) to adulthood (female predominance) has been described, but for allergic rhinitis this remains unclear. We aimed to examine sex- and age-group-specific differences in allergic rhinitis prevalence by systematically evaluating studies from across the globe. METHODS: A systematic search of MEDLINE and Embase for population-based cross-sectional studies was performed regardless of the language of publication...
April 29, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28380495/risk-factors-for-severe-reactions-during-double-blind-placebo-controlled-food-challenges
#12
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Severe anaphylactic symptoms can occur during oral food challenges (OFCs). Thus, high-risk patients (e.g., patients with a history of anaphylaxis or high antigen-specific immunoglobulin E [IgE] levels) must carefully undergo OFCs in hospitals. We attempted to identify the risk factors for severe symptoms during OFC testing among high-risk patients. METHODS: We retrospectively evaluated patients' characteristics and severe symptoms that were experienced during a double-blind placebo-controlled food challenge test performed before the patients underwent oral immunotherapy between June 2008 and June 2012...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28380494/accelerated-up-dosing-of-subcutaneous-immunotherapy-with-a-registered-allergoid-birch-pollen-preparation
#13
Krzysztof Buczyłko, Jan F van der Werf, Diderik Boot, Ronald van Ree
BACKGROUND: Early pollen flight and new allergens prolonging the pollen season means that the time for up-dosing of allergen-specific subcutaneous immunotherapy (SCIT) outside the pollen season becomes shorter. Hence, for patients who wish or need to be up-dosed faster, an accelerated induction regimen would provide a useful treatment option. METHODS: An accelerated up-dosing regimen (0.1-0.3-0.5 mL at weekly intervals) was compared to conventional up-dosing (0...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28380487/effectiveness-of-autologous-whole-blood-injections-in-patients-with-refractory-chronic-spontaneous-urticaria
#14
Nikolaos Aggelis Kitsioulis, Paraskevi Xepapadaki, Aggeliki-Victoria Roussaki-Schulze, Nikolaos Papadopoulos, Efterpi Zafiriou
BACKGROUND: Nonsedating antihistamines are the treatment of choice for chronic spontaneous urticaria (CSU), while omalizumab and immunosuppressants have also been approved as an add-on treatment. Autologous whole-blood injection (AWBI) has been used in previous studies with ambiguous results. The aim of our study was to evaluate changes in the Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and Chronic Urticaria Quality of Life (CU-Q2oL) score, and also the association of serologic markers with disease severity measures after AWBI...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28380482/allergic-and-nonallergic-asthma-have-distinct-phenotypic-and-genotypic-features
#15
Priscila Takejima, Rosana Câmara Agondi, Helcio Rodrigues, Marcelo Vivolo Aun, Jorge Kalil, Pedro Giavina-Bianchi
BACKGROUND: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. METHODS: A total of 109 patients with asthma were prospectively followed during 2 years...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28380479/serological-reactivity-and-identification-of-immunoglobulin-e-binding-polypeptides-of-ganoderma-applanatum-crude-spore-cytoplasmic-extract-in-puerto-rican-subjects
#16
Frances Vilá-Héreter, Félix E Rivera-Mariani, Benjamín Bolaños-Rosero
BACKGROUND: The allergenic potential of Ganoderma applanatum basidiospores has been demonstrated previously in Puerto Rico. However, basidiomycete allergens are not available for inclusion in allergy diagnostic panels. Therefore, we sought to confirm allergic sensitization to G. applanatum crude spore cytoplasmic extract through reactivity in serological assays and detection of immunoglobulin E (IgE)-binding polypeptides. METHODS: Via an indirect ELISA, serological reactivity was compared between groups of individuals with different allergic profiles...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28380475/long-term-follow-up-of-children-after-venom-immunotherapy-low-adherence-to-anaphylaxis-guidelines
#17
Claudia Fiedler, Ulrich Miehe, Regina Treudler, Wieland Kiess, Freerk Prenzel
BACKGROUND: Data on the long-term outcome of children after specific venom immunotherapy (VIT) are limited. Therefore, we assessed sting recurrence and anaphylaxis relapse rates as well as adherence to anaphylaxis guidelines with regard to the availability of emergency equipment and education status. METHODS: For this long-term survey, data of 311 children with a history of anaphylactic reactions to hymenoptera stings were collected by chart review. We included patients who were treated with a 3-year VIT between 1993 and 2009 and had completed a questionnaire...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28315874/multiple-drug-hypersensitivity
#18
Werner J Pichler, Yuttana Srinoulprasert, James Yun, Oliver Hausmann
Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS). Subsequent symptoms due to another drug often appear in the following weeks, overlapping with the first DHR, or months to years later after resolution of the initial presentation. The second DHR includes exanthema, erythroderma, DRESS, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hepatitis, and agranulocytosis...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28273659/self-reported-allergic-rhinitis-and-or-allergic-conjunctivitis-associate-with-il13-rs20541-polymorphism-in-finnish-adult-asthma-patients
#19
Kati Ådjers, Annika Luukkainen, Juha Pekkanen, Mikko Hurme, Heini Huhtala, Risto Renkonen, De Yun Wang, Mika J Mäkelä, Jussi Karjalainen, Sanna Toppila-Salmi
BACKGROUND: Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics. METHODS: A population-based sample of Finnish adult asthma patients (n = 1,156) and matched controls (n = 1,792) filled in a questionnaire. Asthma was diagnosed based on a typical history of asthma symptoms and lung function tests...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28268214/identifying-epithelial-endocytotic-mechanisms-of-the-peanut-allergens-ara-h-1-and-ara-h-2
#20
Dwan Price, M Leigh Ackland, Cenk Suphioglu
BACKGROUND: Peanuts are still one of the highest contributors to anaphylactic deaths after ingestion of a food allergen. At the molecular level, interactions between peanut allergens and the intestinal epithelium are largely unexplored. Previous findings by our research group demonstrated that the major peanut allergens, i.e., Ara h 1, Ara h 2, Ara h 3, and Ara h 6, were able to cross the Caco-2 human cell culture model of the intestinal epithelium. This research broadened our investigation to identify the mechanisms by which the Caco-2 monolayers uptake peanut allergens, specifically by endocytosis...
2017: International Archives of Allergy and Immunology
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