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International Archives of Allergy and Immunology

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https://www.readbyqxmd.com/read/28793302/safety-of-adrenaline-use-in-anaphylaxis-a-multicentre-register
#1
Victòria Cardona, Laia Ferré-Ybarz, Mar Guilarte, Nuria Moreno-Pérez, Catalina Gómez-Galán, Eva Alcoceba-Borràs, Maria Belén Delavalle, Teresa Garriga-Baraut
BACKGROUND: The use of intramuscular adrenaline to treat anaphylaxis is suboptimal, despite being the first-line treatment recommended by national and international anaphylaxis guidelines. Fear of potentially severe side effects may be one of the underlying factors. The aim of this study was to assess the incidence and severity of adverse side effects after the use of adrenaline in anaphylaxis, as well as potential risk factors. METHODS: Observational study based on a multicenter online registry of cases of adrenaline administration for suspected anaphylaxis...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28787742/a-pilot-study-investigating-clinical-responses-and-biological-pathways-of-azelastine-fluticasone-in-nonallergic-vasomotor-rhinitis-before-and-after-cold-dry-air-provocation
#2
Umesh Singh, Jonathan A Bernstein, Holly Lorentz, Tara Sadoway, Victoria Nelson, Piyush Patel, Anne Marie Salapatek
BACKGROUND: Nonallergic vasomotor rhinitis (NAVMR) has been considered a diagnosis by exclusion due to unknown mechanisms or lack of diagnostic biomarkers. METHODS: To determine clinical responses and biological pathways in NAVMR subjects challenged to cold dry air (CDA) in an environmental exposure chamber (EEC) pre- and posttreatment with azelastine/fluticasone (AzeFlu), 30 NAVMR subjects, prescreened for CDA-induced symptoms (approx. 14°C, <15% relative humidity, ×1 h) were randomized to treatment with AzeFlu (n = 20) or placebo (n = 10) for 2 weeks...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28787739/the-trend-of-change-of-allergic-diseases-over-the-years-three-repeated-surveys-from-1994-to-2014
#3
Dilek Doğruel, Gülbin Bingöl, Derya Ufuk Altıntaş, Gülşah Seydaoğlu, Ahmet Erkan, Mustafa Yılmaz
BACKGROUND: Although it is known that there has been an increase in asthma and allergic diseases among school-aged children, results vary between countries. The aim of this study was to examine trends in the prevalence of these diseases in the city of Adana (south Turkey) over the last 20 years based on the results of 3 cross-sectional studies. METHODS: Three cross-sectional surveys were performed 10 years apart in south Turkey. Here, we compare the surveys conducted among children between the ages of 6 and 14 years from 1994, 2004, and 2014...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28787736/molecular-recognition-profiles-and-clinical-patterns-of-pr-10-sensitization-in-a-birch-free-mediterranean-area
#4
Enrico Scala, Damiano Abeni, Lorenzo Cecchi, Emma Cristina Guerra, Maria Locanto, Lia Pirrotta, Mauro Giani, Riccardo Asero
BACKGROUND: The order Fagales represents an important cause of tree-pollen allergy in northern countries. We investigated the IgE recognition profiles, mutual relationships, and association with clinical symptoms of a panel of allergens belonging to the PR-10 family, the main proteins responsible for Fagales allergy (Act d 8, Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1). METHODS: A total of 526 PR-10-reactive subjects living in central and southern Italy were studied by ImmunoCAP-ISAC-112 microarray analysis...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28787733/association-between-caesarean-delivery-and-isolated-doses-of-formula-feeding-in-cow-milk-allergy
#5
Francisco Gil, Ana Amezqueta, Diana Martinez, Elena Aznal, Veronica Etayo, Teodoro Durá, Félix Sánchez-Valverde
BACKGROUND: Cow milk allergy (CMA) is the most common food allergy in breastfed infants. The aim of this study is to verify whether certain perinatal factors may influence the development of CMA immunoglobulin E (IgE)+. METHODS: A retrospective, observational study of case and control groups was carried out. Information was collected of patients with CMA IgE+ from our department during the years 1990-2013. Patients of the same age and sex were recruited for the control group...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28787729/local-allergic-rhinitis-in-adult-patients-with-chronic-nasal-symptoms
#6
Anna Krajewska-Wojtys, Jerzy Jarzab, Kamila Zawadzińska, Katarzyna Pyrkosz, Andrzej Bozek
BACKGROUND: Local allergic rhinitis (LAR) remains an underdiagnosed condition characterized by the local production of IgE antibodies during the natural exposure to aeroallergens. The prevalence of LAR in adult patients with a previous diagnosis of non-AR was assessed. MATERIAL AND METHODS: Eighty-four patients with perennial nasal allergy symptoms but a negative skin prick test and specific IgE antibodies against common inhalant allergens were included in the study...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28787717/modulation-of-cd4-t-helper-cell-memory-responses-in-the-human-skin
#7
Elisabetta Padovan
Immunological memory is defined as the capacity to mount faster and more effective immune responses against antigenic challenges that have been previously encountered by the host. CD4+ T helper (Th) cells play central roles in the establishment of immunological memory as they assist the functions of other leukocytes. Th cells express polarized cytokine profiles and distinct migratory and seeding capacities, but also retain a certain functional plasticity that allows them to modulate their proliferation, activity, and homing behaviour upon need...
August 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28662509/preventing-hereditary-angioedema-attacks-in-children-using-cinryze%C3%A2-interim-efficacy-and-safety-phase-3-findings
#8
Emel Aygören-Pürsün, Daniel Soteres, Dumitru Moldovan, Jim Christensen, Arthur Van Leerberghe, James Hao, Jennifer Schranz, Kraig W Jacobson, Inmaculada Martinez-Saguer
BACKGROUND: Hereditary angioedema (HAE) is a rare genetic disease causing unpredictable and potentially life-threatening subcutaneous and submucosal edematous attacks. Cinryze® (Shire ViroPharma Inc., Lexington, MA, USA), a nanofiltered C1 inhibitor (C1-INH), is approved in Europe for the treatment, preprocedure prevention, and routine prophylaxis of HAE attacks, and for the routine prophylaxis of attacks in the USA. This phase 3 study assessed the safety and efficacy of 2 C1-INH doses in preventing attacks in children aged 6-11 years...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28654924/influence-of-intrinsic-and-lifestyle-factors-on-the-development-of-ige-sensitization
#9
Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: IgE sensitization is a prerequisite for the development of allergic symptoms. The investigation of factors influencing the development of IgE is therefore crucial for understanding the onset of allergic diseases. METHODS: This epidemiological study investigated personal, intrinsic, and lifestyle factors in a nonselected cohort of 501 Austrian adolescents (aged 12-21 years). IgE levels to 112 allergen molecules were analyzed in the serum of participants using the ImmunoCAP ISAC®...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28654921/effect-of-maternal-dietary-patterns-during-pregnancy-on-self-reported-allergic-diseases-in-the-first-3-years-of-life-results-from-the-gusto-study
#10
Evelyn Xiu Ling Loo, Lynn Ong, Anne Goh, Ai-Ru Chia, Oon Hoe Teoh, Marjorelee T Colega, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D Gluckman, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Mary Foong-Fong Chong, Lynette Pei-Chi Shek
BACKGROUND: Maternal diet during pregnancy has been suggested to be an important early-life exposure that influences immune tolerance and the development of allergic diseases in offspring. METHODS: We examined the relationship between maternal dietary patterns assessed using 24-h recalls and food diaries at 26-28 weeks of pregnancy and the subsequent development of allergic outcomes in the offspring in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28654920/greater-real-life-diagnostic-efficacy-of-allergen-molecule-based-diagnosis-for-prescription-of-immunotherapy-in-an-area-with-multiple-pollen-exposure
#11
Ulbosin Saltabayeva, Victoria Garib, Marina Morenko, Rafail Rosenson, Zhanat Ispayeva, Madina Gatauova, Loreta Zulus, Alexander Karaulov, Felix Gastager, Rudolf Valenta
BACKGROUND: Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing for the identification of the disease-causing allergen sources. The study was conducted in an area where patients are exposed to pollen from multiple sources (trees, grasses, and weeds) at the same time to compare the diagnostic efficiency of the 2 forms of diagnosis...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28586781/house-dust-mites-induce-production-of-endothelin-1-and-matrix-metalloproteinase-9-in-keratinocytes-via-proteinase-activated-receptor-2-activation
#12
Yoshihito Yamada, Tatsumi Matsumoto
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and abnormal immune response. House dust mites (HDM) are a major source of allergens, some of which have cysteine and serine protease activities. Keratinocytes stimulated by HDM-derived proteases have been suggested to contribute to the pathogenesis of AD by producing various cytokines. However, whether keratinocytes contribute to the induction of pruritus in AD, especially by producing pruritus-related mediators upon stimulation with HDM-derived proteases, has not been fully elucidated...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28586774/the-use-of-mouse-asthma-models-to-successfully-discover-and-develop-novel-drugs
#13
Michelle M Epstein, Cornelia Tilp, Klaus J Erb
The past 20 years have seen a proliferation of scientific data on the pathophysiology of asthma. Most of these data were generated in mice using tool reagents, gene-deficient or transgenic animals. In contrast, studies on disease pathogenesis in patients are scarce. Previously, a good novel antiasthma target for drug development was one that abrogated asthma in mice when it was knocked out, neutralized or induced asthma when it was overexpressed. This type of approach led to many drug candidates that worked in mice but unfortunately failed in patients, thereby demonstrating that the results of experiments in mice are not always predictive of clinical efficacy...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28578324/eppikajutsuto-protects-against-food-allergy-induced-by-ovalbumin-in-a-murine-model
#14
Teruaki Matsui, Hirotaka Yamashita, Mikito Mori, Hiroyuki Tanaka, Naoki Inagaki
BACKGROUND: Currently, there are no efficient medications available for the prevention and treatment of food allergy (FA). Herbal medicines, including traditional Japanese Kampo medicines (TJKMs), are promising therapeutic drugs. METHODS: We screened 18 TJKMs for treatment of FA symptoms in a mouse FA model induced by ovalbumin (OVA). BALB/c mice were sensitized intraperitoneally by an OVA/aluminum hydroxide gel mixture followed by 4 booster doses of oral OVA and FA symptom induction by 50 mg of OVA...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28505618/use-of-epinephrine-in-patients-with-drug-induced-anaphylaxis-an-analysis-of-the-beijing-pharmacovigilance-database
#15
Tiansheng Wang, Xiang Ma, Yan Xing, Shusen Sun, Hua Zhang, Til Stürmer, Bin Wang, Xiaotong Li, Huilin Tang, Ligong Jiao, Suodi Zhai
BACKGROUND: Few studies assessing the use of epinephrine in drug-induced anaphylaxis (DIA) in the hospital setting are available. We utilized the Beijing Pharmacovigilance Database (BPD) to evaluate the appropriateness of epinephrine for DIA management. METHODS: DIA cases collected in the BPD from January 2004 to December 2014 were adjudicated and analyzed for demographics, causative drugs, clinical signs, outcomes, initial treatment, route, dosing, and cardiovascular adverse events (CAE) of epinephrine...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28494467/expression-and-characterization-of-functional-recombinant-bet-v-1-0101-in-the-chloroplast-of-chlamydomonas-reinhardtii
#16
Sonja Hirschl, Claudia Ralser, Claudia Asam, Alessandro Gangitano, Sara Huber, Christof Ebner, Barbara Bohle, Martin Wolf, Peter Briza, Fatima Ferreira, Christoph Griesbeck, Michael Wallner
BACKGROUND: Allergen immunotherapy (AIT) still plays a minor role in the treatment of allergic diseases. To improve the acceptance of AIT by allergic patients, the treatment has to become more convenient and efficacious. One possibility is the oral application of allergens or derivatives thereof. Therefore, we sought to produce a recombinant allergen in the green alga Chlamydomonas reinhardtii as a novel production platform. METHODS: The major birch pollen allergen Bet v 1 was selected as candidate molecule, and a codon-optimized gene was synthesized and stably integrated into the microalga C...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28494455/the-clinical-impact-of-bet-v-6-in-birch-pollen-sensitized-patients
#17
Donata Gellrich, Katharina Eder, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Bet v 6, a minor birch pollen allergen, is commercially available for allergen-specific IgE antibody testing. However, there is hardly any literature on the clinical impact of Bet v 6. The aim of the present study was to analyze if testing specific IgE against Bet v 6 can add valuable benefit to the standard diagnostics of birch pollen-sensitized patients, especially in patients with unknown sensitization-eliciting allergens. METHODS: Birch pollen-sensitized patients with missing IgE reactivity against Bet v 1, 2, and 4 were tested for specific IgE antibodies against Bet v 6...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28486236/human-invariant-natural-killer-t-cells-respond-to-antigen-presenting-cells-exposed-to-lipids-from-olea-europaea-pollen
#18
Beatriz Abos Gracia, Juan López Relaño, Ana Revilla, Lourdes Castro, Mayte Villalba, Beatriz Martín Adrados, Jose Ramon Regueiro, Edgar Fernández-Malavé, Eduardo Martínez Naves, Manuel Gómez Del Moral
BACKGROUND: Allergic sensitization might be influenced by the lipids present in allergens, which can be recognized by natural killer T (NKT) cells on antigen-presenting cells (APCs). The aim of this study was to analyze the effect of olive pollen lipids in human APCs, including monocytes as well as monocyte-derived macrophages (Mϕ) and dendritic cells (DCs). METHODS: Lipids were extracted from olive (Olea europaea) pollen grains. Invariant (i)NKT cells, monocytes, Mϕ, and DCs were obtained from buffy coats of healthy blood donors, and their cell phenotype was determined by flow cytometry...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28482341/indigo-naturalis-ameliorates-oxazolone-induced-dermatitis-but-aggravates-colitis-by-changing-the-composition-of-gut-microflora
#19
Soichiro Adachi, Namiko Hoshi, Jun Inoue, Eiichiro Yasutomi, Takafumi Otsuka, Ramesh Dhakhwa, Zi Wang, Yuna Koo, Toshihiro Takamatsu, Yuriko Matsumura, Haruka Yamairi, Daisuke Watanabe, Makoto Ooi, Toshihito Tanahashi, Shin Nishiumi, Masaru Yoshida, Takeshi Azuma
BACKGROUND: Indigo naturalis (IND) is an herbal medicine that has been used as an anti-inflammatory agent to treat diseases including dermatitis and inflammatory bowel disease in China. However, the mechanism by which IND exerts its immunomodulatory effect is not well understood. METHODS: A murine model of dermatitis and inflammatory bowel disease, both induced by oxazolone (OXA), was treated with IND. The severity of dermatitis was evaluated based on ear thickness measurements and histological scoring...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28467993/recombinant-allergens-in-structural-biology-diagnosis-and-immunotherapy
#20
Angelika Tscheppe, Heimo Breiteneder
The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible...
2017: International Archives of Allergy and Immunology
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