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International Archives of Allergy and Immunology

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https://www.readbyqxmd.com/read/30544119/expression-density-of-receptors-as-a-potent-regulator-of-cell-function-and-property-in-health-and-pathology
#1
REVIEW
Sergey Vitalievich Sennikov, Alina A Alshevskaya, Julia Zhukova, Irina Belomestnova, Alexander V Karaulov, Julia A Lopatnikova
The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy...
December 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30544116/clinical-response-to-subcutaneous-dermatophagoides-pteronyssinus-immunotherapy-in-children-with-allergic-rhinitis-and-asthma-is-independent-of-sensitization-to-blomia-tropicalis-allergens
#2
Shi Chen, Yiwu Zheng, Bing Chen, Haifeng Zhong, Feng Liao, Ling Wang, Siu Fu Hui, Xuxin Lai
BACKGROUND: Dermatophagoides pteronyssinus (DP) and Blomia tropicalis (BT) are the dominant house dust mites inducing allergic diseases in tropical climates. It is not known whether the efficacy of DP subcutaneous immunotherapy (SCIT) is similar in patients sensitized to DP alone or to both DP and BT. METHOD: Ninety-five children (5-17 years old) affected by asthma with rhinitis and sensitized to both DP and BT received 3 years of DP-SCIT. Clinical symptom and medication scores, serum-specific IgE and IgG4 were evaluated during DP-SCIT...
December 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30544107/characterization-of-patients-with-ibuprofen-hypersensitivity
#3
Erika Yue Lee, Daniel Teitelbaum, Marcus Chiam, Peter Vadas
BACKGROUND: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity. OBJECTIVES: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. METHODS: A retrospective chart review of patients diagnosed with ibuprofen allergy was conducted between 2008 and 2016 in an allergy clinic at a tertiary care academic institution...
December 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30522098/cigarette-smoke-extract-promotes-tim4-expression-in-murine-dendritic-cells-leading-to-th2-polarization-through-erk-dependent-pathways
#4
Rui Jiang, Yaping Jiang, Ping Xia, Guangwei Luo, Wei Huang, Zhimin Hu, Guilian Cheng, Yin Xiong, Yueqin Wang, Tianpen Cui
Smoking is considered to be the main source of indoor pollution, and it has been identified as an important environmental factor contributing to asthma onset. We know that T helper 2 (Th2) response plays a crucial role in the process of asthma disease. We have investigated the reaction of cigarette smoke extract (CSE) on Th polarization which is controlled by dendritic cells (DCs). Stimulated by CSE, immature DCs from murine bone marrow showed upregulated levels of TIM4. Cocultured with CD4+ T cells, stimulated DCs increased the ratio of IL-4+ versus IFN-γ+ of CD4+ T cells...
December 6, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30517941/suspected-reaction-with-cephalosporin-may-be-a-predictive-factor-for-%C3%AE-lactam-allergy-in-children
#5
Isil Eser Simsek, Mujde Tuba Cogurlu, Metin Aydogan
BACKGROUND: Most children diagnosed with β-lactam allergy based only on history are not truly allergic, and mislabeling leads to use of less effective and more costly alternative broader-spectrum antibiotics, significantly increasing drug resistance. OBJECTIVE: To determine the frequency and risk factors of confirmed allergy in patients with β-lactam allergy reported by parents or their doctors and evaluate cross-reactivity between β-lactams in children with confirmed allergy...
December 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30517928/an-animal-model-for-wheat-allergy-skin-sensitisation-a-comparative-study-in-naive-versus-tolerant-brown-norway-rats
#6
Anne-Sofie Ravn Ballegaard, Charlotte Bernhard Madsen, Katrine Lindholm Bøgh
BACKGROUND: Allergic sensitisation to foods may occur in infancy without prior oral exposure to the offending food, leading to the assumption that food allergy sensitisation may occur through the skin. Concerns have been raised regarding the safety of use of personal care products containing hydrolysed wheat proteins, since these products have been shown to induce allergy through the skin, and even cause an abrogation of an already established oral tolerance. OBJECTIVE: To establish an animal model for food allergy skin sensitisation and compare the sensitising capacity of an unmodified and an acid-hydrolysed gluten product via slightly damaged skin in naïve versus tolerant rats...
December 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30485850/immediate-type-hypersensitivity-cross-reactions-to-proton-pump-inhibitors-a-descriptive-study-of-data-from-the-french-national-pharmacovigilance-database
#7
Caroline Tourillon, Julien Mahe, Aurélie Baron, Aude Lambert, Mélissa Yélehé-Okouma, Gwenaelle Veyrac, Pascale Jolliet
BACKGROUND: Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been reached. OBJECTIVE: We sought to identify immediate-type hypersensitivity cross-reactions to PPIs using real-world data about hypersensitivity testing from French pharmacovigilance cases...
November 28, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30466080/effects-of-migration-on-allergic-diseases
#8
REVIEW
Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Yanan Zhu, Lynette Pei-Chi Shek
Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from less affluent countries with lower allergy prevalence tend to have a lower prevalence of allergic disorders compared to native-born residents of the more affluent host country. The patterns of allergic disease prevalence also differ between first- and second-generation migrants...
November 22, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30458444/bronchial-asthma-and-bronchial-hyperresponsiveness-and-their-characteristics-in-patients-with-common-variable-immunodeficiency
#9
Tomas Milota, Marketa Bloomfield, Zuzana Parackova, Anna Sediva, Jirina Bartunkova, Rudolf Horvath
BACKGROUND: Common variable immunodeficiency (CVID) is one of the most frequent primary immunodeficiencies and is characterized by disturbed immunoglobulin production and dysregulation of the immune system. Results of previous studies suggest a higher prevalence of bronchial asthma (BA) in CVID patients than in the general population. We initiated this study to evaluate lung functions and identify risk factors for BA and bronchial hyperresponsiveness (BHR) in patients with CVID. METHODS: Twenty-three patients with CVID were included in this study...
November 20, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30448840/evaluation-of-the-potential-risk-factors-for-drug-induced-anaphylaxis-in-adult-patients
#10
Semra Demir, Fusun Erdenen, Asli Gelincik, Derya Unal, Muge Olgac, Raif Coskun, Bahauddin Colakoglu, Suna Buyukozturk
AIM: To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD: The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonanaphylaxis group. The anaphylaxis group was diagnosed according to the criteria of the World Allergy Organization. Skin testing with culprit drugs was performed...
November 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30428479/intranasal-administration-of-il-27-ameliorates-nasal-allergic-responses-and-symptoms
#11
Motohiko Suzuki, Makoto Yokota, Shinya Ozaki, Tamami Matsumoto
BACKGROUND: Interleukin 27 (IL-27) is an initiator of the Th1 response and inhibits inflammatory responses. In a mouse model of asthma, administration of IL-27 reduced eosinophil numbers in bronchoalveolar lavage fluid and airway hyperresponsiveness. However, it is unclear whether administration of IL-27 can inhibit symptoms of allergic diseases and allergic rhinitis as a therapeutic agent. Therefore, we investigated the in vivo effect of IL-27 on nasal symptoms and allergic rhinitis...
November 14, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30423562/recent-advances-in-experimental-allergy
#12
REVIEW
Olivia Joan Adams, Stephan von Gunten
Atopic disorders are on the rise and pose a great burden on society. A better understanding of the underlying mechanisms is required for the development of improved or novel therapeutic strategies. Here we aim to highlight recent advances in experimental allergy, with a particular focus on proposed treatment alternatives for airway disorders, atopic dermatitis, and food allergy. Furthermore, we discuss recent work focusing on molecular and cellular mechanisms that might offer candidates for future preventive or therapeutic intervention...
November 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30415264/urine-bacteria-derived-extracellular-vesicles-and-allergic-airway-diseases-in-children
#13
Mona Samra, Soo Kyung Nam, Dae Hyun Lim, Dong Hyun Kim, Jinho Yang, Yoon-Keun Kim, Jeong Hee Kim
BACKGROUND: Microbiota and human allergic airway diseases have been proven to be interrelated. Bacteria-derived extracellular vesicle (EV)s are known to play important roles in interbacterial and human-bacteria communications, but their relationship with allergies has not been examined yet. Urine EVs were investigated to determine whether they could be used as biomarkers for monitoring allergic airway diseases in children. METHODS: Subjects were 4 groups of chronic rhinitis (CR), allergic rhinitis (AR), atopic asthma (AS) and healthy controls...
November 9, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30408809/effect-of-cellulose-powder-on-human-nasal-epithelial-cell-activity-and-ciliary-beat-frequency
#14
Min Zhou, Ke-Jun Zuo, Zhao-Feng Xu, Wei-Jie Guan, Li-Jie Jiang, Xin Luo, Rui Zheng, Dang Wang, Yu-Jie Cao, Yang Chen, Fei Yang, Chen Liu, Jian-Bo Shi, Yin-Yan Lai
BACKGROUND: Cellulose powder (CP) has been reported as a safe and effective complementary treatment for allergic rhinitis (AR). Currently, CP has gained increasing application for clinical management worldwide, particularly in China. However, studies focusing on the effect of CP on normal human nasal epithelial cells (hNECs) and ciliary function are lacking. Here, we aimed to explore the adverse effects of CP on the activity and ciliary function of hNECs. METHODS: We biopsied ethmoid sinus or middle turbinate tissues during surgical resection from control subjects who underwent endoscopic sinus surgery for diseases other than AR...
November 8, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30408806/mir-202-5p-promotes-m2-polarization-in-allergic-rhinitis-by-targeting-matn2
#15
Li Wang, Xueyan Liu, Xicheng Song, Lei Dong, Dawei Liu
BACKGROUND: The aim of this study was to investigate the effect of MiR-202-5p on macrophages involved in allergic rhinitis. METHODS: Thirty allergic rhinitis patients and 10 healthy controls were recruited. Nasal lavage was utilized to collect mucosal tissues and mucus-derived macrophages. Flow cytometry was used to detect and sort type 2 macrophages, and qRT-PCR and Western blot were adopted to determine the expression of miR-202-5p and MATN2. Luciferase reporter assay and biotin-RNA pulldown were performed to testify the direct binding of miR-202-5p with MATN2...
November 8, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30404088/evaluation-of-a-standardized-bakery-product-sutmek-as-a-potential-tool-for-baked-milk-tolerance-and-immunotherapy-research-studies
#16
Ayca Kiykim, Elif Karakoc-Aydiner, Esra Gunes, Ercan Nain, Ismail Ogulur, Duygu Yazici, Sule Aktac, Ayse Humeyra Bicer, Cansin Sackesen, Safa Baris, Ahmet Ozen
BACKGROUND AND OBJECTIVES: About 65-80% of children with IgE-mediated cow's milk allergy (CMA) can tolerate extensively heated milk. We have invested in the mass fabrication of a test product containing milk protein baked at 180°C for 30 min (SUTMEK-milk) and a milk-free placebo (SUTMEK-placebo) to carry out a standardised double-blind placebo-controlled food challenge (DBPCFC) test in patients with CMA. METHODS: We studied children with IgE-mediated CMA between 13 and 48 months of age...
November 7, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30399611/recent-advances-in-clinical-allergy-and-immunology
#17
REVIEW
Dagmar Simon
Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients' physical and psychological health, the huge burden they place on patients' quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new technologies such as "omics" has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets...
November 6, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30396176/omalizumab-in-chronic-urticaria-an-italian-survey
#18
Giovanni Damiani, Marco Diani, Rosalynn R Z Conic, Laura Colli, Silvia Ferrucci, Emanuela Martina, Anna Maria Offidani, Paolo Daniele Maria Pigatto
Omalizumab is approved for use in chronic spontaneous urticaria (CSU); however, it is not approved for chronic inducible urticaria (CIndU). The aim of the present study was to assess the effectiveness of omalizumab in treating CSU and CIndU in Italy. This is a multicentre prospective observational real-life study involving patients with severe urticaria capable of undergoing omalizumab therapy. We enrolled 127 patients (59.1% females), ranging in age from 15 to 83 years, 69.3% had CSU alone, 26.8% had CSU and CIndU, and 3...
November 5, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30391960/notch-signaling-promotes-development-of-allergic-rhinitis-by-suppressing-foxp3-expression-and-treg-cell-differentiation
#19
Wo-Er Jiao, Jin-Feng Wei, Yong-Gang Kong, Yu Xu, Ze-Zhang Tao, Shi-Ming Chen
BACKGROUND: The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. OBJECTIVE: To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. METHOD: The sera of 100 patients with AR and 50 controls were collected to assess the differences in Notch1, Jagged1, and DLL1 (Delta-like 1) expression...
November 2, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/30391954/intralymphatic-immunotherapy-update-and-unmet-needs
#20
REVIEW
Gabriela Senti, Andreas U Freiburghaus, Désirée Larenas-Linnemann, Hans Jürgen Hoffmann, Amber M Patterson, Ludger Klimek, Danilo Di Bona, Oliver Pfaar, Lars Ahlbeck, Mübeccel Akdis, Dan Weinfeld, Francisco A Contreras-Verduzco, Alvaro Pedroza-Melendez, Søren H Skaarup, Sang Min Lee, Lars-Olaf Cardell, Johannes M Schmid, Ulla Westin, Ralph Dollner, Thomas M Kündig
Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i.e., directly into lymph nodes - intralymphatic immunotherapy (ILIT)...
November 2, 2018: International Archives of Allergy and Immunology
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