journal
MENU ▼
Read by QxMD icon Read
search

Human Reproduction Update

journal
https://www.readbyqxmd.com/read/30239705/uterine-stem-cells-from-basic-research-to-advanced-cell-therapies
#1
Xavier Santamaria, Aymara Mas, Irene Cervelló, Hugh Taylor, Carlos Simon
BACKGROUND: Stem cell research in the endometrium and myometrium from animal models and humans has led to the identification of endometrial/myometrial stem cells and their niches. This basic knowledge is beginning to be translated to clinical use for incurable uterine pathologies. Additionally, the implication of bone marrow-derived stem cells (BMDSCs) in uterine physiology has opened the field for the exploration of an exogenous and autologous source of stem cells. OBJECTIVE AND RATIONALE: In this review, we outline the progress of endometrial and myometrial stem/progenitor cells in both human and mouse models from their characterization to their clinical application, indicating roles in Asherman syndrome, atrophic endometrium and tissue engineering, among others...
September 15, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30204882/the-psychological-impact-of-early-pregnancy-loss
#2
Jessica Farren, Nicola Mitchell-Jones, Jan Y Verbakel, Dirk Timmerman, Maria Jalmbrant, Tom Bourne
BACKGROUND: Early pregnancy loss (EPL) is a common event, with scope for long-term personal and societal impact. There are three decades worth of published evidence of profound psychological sequelae in a significant proportion of women. However, the wide variety of outcomes, screening instruments, assessment timings and geographical locations makes it challenging to form a coherent picture of the morbidity within the whole group and its subgroups. OBJECTIVE AND RATIONALE: This review aims to investigate three questions...
September 11, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30204868/insulin-like-peptide-3-insl3-is-a-major-regulator-of-female-reproductive-physiology
#3
Richard Ivell, Ravinder Anand-Ivell
BACKGROUND: Insulin-like peptide 3 (INSL3) is a member of the relaxin family of neohormones which has evolved to address specifically mammalian aspects of reproduction related to viviparity and internal fertilization. It was originally identified as a major product of testicular Leydig cells and has proved to be an important biomarker of Leydig cell functional capacity. However, INSL3 is also produced by theca interna cells of growing antral follicles and is secreted into the bloodstream in phases corresponding to the number and health of the follicles...
September 11, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30165449/ureteral-endometriosis-a-systematic-review-of-epidemiology-pathogenesis-diagnosis-treatment-risk-of-malignant-transformation-and-fertility
#4
Fabio Barra, Carolina Scala, Ennio Biscaldi, Valerio Gaetano Vellone, Marcello Ceccaroni, Carlo Terrone, Simone Ferrero
BACKGROUND: The ureter is the second most common site affected by urinary tract endometriosis, after the bladder. Optimal strategies in the diagnosis and treatment of ureteral endometriosis (UE) are not yet well defined. OBJECTIVE AND RATIONALE: The aim of this study was to systematically review evidence regarding the epidemiology, pathophysiology, diagnosis, medical and surgical treatment, impact on fertility and risk of malignant transformation of UE. SEARCH METHODS: A systematic literature review, by searching the MEDLINE and PUBMED database until April 2018, was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and was registered in the PROSPERO registry (www...
August 28, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30059968/understanding-variation-in-prevalence-estimates-of-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#5
Marina A Skiba, Rakibul M Islam, Robin J Bell, Susan R Davis
BACKGROUND: Polycystic ovary syndrome (PCOS) prevalence estimates vary when different diagnostic criteria are applied. Lack of standardization of individual elements within these criteria may contribute to prevalence differences. OBJECTIVE AND RATIONALE: A systematic review of studies reporting prevalence of PCOS, using at least one of the National Institutes of Health (NIH), Rotterdam or Androgen Excess Society (AE-PCOS) criteria, was conducted. The aim was to investigate the impact on prevalence reporting of different definitions of the clinical elements for PCOS diagnosis...
July 27, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30053022/reply-vascularization-in-endometriosis-and-its-clinical-applications
#6
Matthias W Laschke, Michael D Menger
No abstract text is available yet for this article.
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30052943/vascularization-in-endometriosis-and-its-clinical-applications
#7
N Galazis, A Raza
No abstract text is available yet for this article.
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29992283/epigenetic-regulation-in-development-is-the-mouse-a-good-model-for-the-human
#8
Courtney W Hanna, Hannah Demond, Gavin Kelsey
BACKGROUND: Over the past few years, advances in molecular technologies have allowed unprecedented mapping of epigenetic modifications in gametes and during early embryonic development. This work is allowing a detailed genomic analysis, which for the first time can answer long-standing questions about epigenetic regulation and reprogramming, and highlights differences between mouse and human, the implications of which are only beginning to be explored. OBJECTIVE AND RATIONALE: In this review, we summarise new low-cell molecular methods enabling the interrogation of epigenetic information in gametes and early embryos, the mechanistic insights these have provided, and contrast the findings in mouse and human...
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29924306/clinical-relevance-of-genetic-variants-of-gonadotrophins-and-their-receptors-in-controlled-ovarian-stimulation-a-systematic-review-and-meta-analysis
#9
Carlo Alviggi, Alessandro Conforti, Daniele Santi, Sandro C Esteves, Claus Yding Andersen, Peter Humaidan, Paolo Chiodini, Giuseppe De Placido, Manuela Simoni
BACKGROUND: Genotype has been implicated in the outcome of ovarian stimulation. The analysis of patient-specific genotypes might lead to an individualized pharmacogenomic approach to controlled ovarian stimulation (COS). However, the validity of such an approach remains to be established. OBJECTIVE AND RATIONALE: To define the impact of specific genotype profiles of follicle-stimulating hormone, luteinizing hormone and their receptors (FSHR, LHR and LHCGR) on ovarian stimulation outcome...
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29893860/is-it-time-for-a-paradigm-shift-in-drug-research-and-development-in-endometriosis-adenomyosis
#10
Sun-Wei Guo, Patrick G Groothuis
BACKGROUND: The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did report how they foundered, the reasons why they failed are often completely unclear. Surprisingly, there has been no open discussion on why these trials failed. If the causes for these failed trials remain unelucidated, mistakes made in these failed trials may be repeated in the future...
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29800303/the-contribution-of-human-sperm-proteins-to-the-development-and-epigenome-of-the-preimplantation-embryo
#11
Judit Castillo, Meritxell Jodar, Rafael Oliva
BACKGROUND: Knowledge of the proteomic composition of the gametes is essential to understand reproductive functions. Most of the sperm proteins are related to spermatogenesis and sperm function, but less abundant protein groups with potential post-fertilization roles have also been detected. The current data are challenging our understanding of sperm biology and functionality, demanding an integrated analysis of the proteomic and RNA-seq datasets available for spermatozoa, oocytes and early embryos, in order to unravel the impact of the male gamete on the generation of the new individual...
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29762669/ethics-of-oocyte-banking-for-third-party-assisted-reproduction-a-systematic-review
#12
E M Kool, A M E Bos, R van der Graaf, B C J M Fauser, A L Bredenoord
BACKGROUND: The demand for donor oocytes has increased dramatically over the years. Today people in need of ART with the use of donor oocytes can appeal to commercial or public donor oocyte banks. The introduction of oocyte banks has shed a new light on the practice of ART using donor oocytes. The establishment and maintenance of oocyte banks should be sensitive to the ethical considerations. However, it is currently unclear which ethical aspects have to be taken into account. OBJECTIVE AND RATIONALE: The aim of this article is to identify the ethical aspects of establishing and maintaining oocyte banks for third-party ART...
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29757366/a-systematic-review-and-meta-analysis-reveals-pervasive-effects-of-germline-mitochondrial-replacement-on-components-of-health
#13
Ralph Dobler, Damian K Dowling, Edward H Morrow, Klaus Reinhardt
BACKGROUND: Mitochondrial replacement, a form of nuclear transfer, has been proposed as a germline therapy to prevent the transmission of mitochondrial diseases. Mitochondrial replacement therapy has been licensed for clinical application in the UK, and already carried out in other countries, but little is known about negative or unintended effects on the health of offspring born using this technique. OBJECTIVE AND RATIONALE: Studies in invertebrate models have used techniques that achieve mitochondrial replacement to create offspring with novel combinations of mitochondrial and nuclear genotype...
September 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29912342/reply-excessive-fetal-growth-in-frozen-embryo-transfer-false-alarm-or-clinical-concern
#14
Abha Maheshwari, Mark Hamilton, Asha Shetty, Edwin Amalraj Raja, Siladitya Bhattacharya
No abstract text is available yet for this article.
July 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29912325/excessive-fetal-growth-in-frozen-embryo-transfer-false-alarm-or-clinical-concern
#15
Edgardo Somigliana, Valeria Stella Vanni, Andrea Busnelli, Marco Reschini, Enrico Papaleo, Paola Viganò
No abstract text is available yet for this article.
July 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29726895/the-risk-of-tese-induced-hypogonadism-a-systematic-review-and-meta-analysis
#16
Jitske Eliveld, Madelon van Wely, Andreas Meißner, Sjoerd Repping, Fulco van der Veen, Ans M M van Pelt
BACKGROUND: Testicular sperm extraction (TESE) is a surgical procedure to retrieve spermatozoa from the testes of men with azoospermia to help them achieve biological parenthood. Although effective, the surgical procedure is not without complications and haematoma, devascularization, inflammation and a decrease in testosterone levels have been described as such. The prevalence and duration of hypogonadism and associated symptoms after TESE have not been studied systematically. OBJECTIVE AND RATIONALE: In this systematic review we addressed the following research questions: Are serum testosterone levels decreased after TESE and, if so, do these levels recover over time? What is the prevalence of symptoms and signs related to hypogonadism after TESE and are they related to testosterone levels? SEARCH METHODS: We searched the databases Pubmed and Embase from 1 January 1993 to 26 June 2017...
July 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29697794/non-coding-rnas-in-endometriosis-a-narrative-review
#17
Kavita Panir, John E Schjenken, Sarah A Robertson, M Louise Hull
BACKGROUND: Endometriosis is a benign gynaecological disorder, which affects 10% of reproductive-aged women and is characterized by endometrial cells from the lining of the uterus being found outside the uterine cavity. However, the pathophysiological mechanisms causing the development of this heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. There is international recognition that accurate non-invasive diagnostic tests and more effective therapies are urgently needed...
July 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29668899/how-uterine-microbiota-might-be-responsible-for-a-receptive-fertile-endometrium
#18
Marilen Benner, Gerben Ferwerda, Irma Joosten, Renate G van der Molen
BACKGROUND: Fertility depends on a receptive state of the endometrium, influenced by hormonal and anatomical adaptations, as well as the immune system. Local and systemic immunity is greatly influenced by microbiota. Recent discoveries of 16S rRNA in the endometrium and the ability to detect low-biomass microbiota fueled the notion that the uterus may be indeed a non-sterile compartment. To date, the concept of the 'sterile womb' focuses on in utero effects of microbiota on offspring and neonatal immunity...
July 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29648649/infectious-inflammatory-and-autoimmune-male-factor-infertility-how-do-rodent-models-inform-clinical-practice
#19
Monika Fijak, Adrian Pilatz, Mark P Hedger, Nour Nicolas, Sudhanshu Bhushan, Vera Michel, Kenneth S K Tung, Hans-Christian Schuppe, Andreas Meinhardt
BACKGROUND: Infection and inflammation of the reproductive tract are significant causes of male factor infertility. Ascending infections caused by sexually transmitted bacteria or urinary tract pathogens represent the most frequent aetiology of epididymo-orchitis, but viral, haematogenous dissemination is also a contributory factor. Limitations in adequate diagnosis and therapy reflect an obvious need for further understanding of human epididymal and testicular immunopathologies and their contribution to infertility...
July 1, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29608700/trophoblast-retrieval-and-isolation-from-the-cervix-origins-of-cervical-trophoblasts-and-their-potential-value-for-risk-assessment-of-ongoing-pregnancies
#20
Gerit Moser, Sascha Drewlo, Berthold Huppertz, D Randall Armant
BACKGROUND: Early during human development, the trophoblast lineage differentiates to commence placentation. Where the placenta contacts the uterine decidua, extravillous trophoblast (EVT) cells differentiate and invade maternal tissues. EVT cells, identified by expression of HLA-G, invade into uterine blood vessels (endovascular EVT), as well as glands (endoglandular EVT), and open such luminal structures towards the intervillous space of the placenta. Endoglandular invasion diverts the contents of uterine glands to the intervillous space, while glands near the margin of the placenta that also contain endoglandular EVT cells open into the reproductive tract...
July 1, 2018: Human Reproduction Update
journal
journal
20121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"