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Human Reproduction

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https://www.readbyqxmd.com/read/29688494/discordance-between-serum-anti-m%C3%A3-llerian-hormone-concentrations-and-antral-follicle-counts-not-only-technical-issues
#1
M Š Alebic, N Stojanovic, D Dewailly
STUDY QUESTION: Do patient-specific features contribute to the differences between measured serum anti-Müllerian hormone (AMH) concentrations and AMH values expected from the corresponding antral follicle count (AFC)? SUMMARY ANSWER: Patient-specific features contribute to the differences between measured AMH values and AMH values expected from the corresponding AFC (AMHp), potentially through their effect on follicular AMH production. WHAT IS KNOWN ALREADY: Both patient counselling and patient management could be hampered by finding of disagreement between AFC and AMH if both are used for the prediction of ovarian response...
April 24, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29688459/assessing-the-clinical-significance-of-elevated-progesterone-during-controlled-ovarian-stimulation-the-unanswered-question-about-embryo-quality
#2
V S Vanni, E Alleva, E Papaleo, M Candiani, E Somigliana, P Viganò
No abstract text is available yet for this article.
April 23, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#3
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684121/incidence-and-prevalence-of-diabetes-and-cost-of-illness-analysis-of-polycystic-ovary-syndrome-a-bayesian-modelling-study
#4
Tao Ding, Paul J Hardiman, Irene Petersen, Gianluca Baio
STUDY QUESTION: What is the incidence/prevalence of type 2 diabetes in women with polycystic ovary syndrome (PCOS) and the economic burden associated with PCOS in the UK? SUMMARY ANSWER: The incidence and prevalence of type 2 diabetes in women with PCOS are 3-33 per 1000 person years and 26.5%, respectively, with an associated annual healthcare burden of at least £237 million in the UK. WHAT IS KNOWN ALREADY: Although observational studies have been designed to assess the incidence of diabetes in women with PCOS, these have been open to criticism because of short periods of follow-up, small sample sizes or invalidated diagnosis of PCOS...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684118/spontaneous-endometriosis-in-cynomolgus-monkeys-as-a-clinically-relevant-experimental-model
#5
A Nishimoto-Kakiuchi, S Netsu, S Okabayashi, K Taniguchi, H Tanimura, A Kato, M Suzuki, T Sankai, R Konno
STUDY QUESTION: Does spontaneous endometriosis in cynomolgus monkeys have the characteristics required of a good experimental model? SUMMARY ANSWER: Spontaneous endometriosis in cynomolgus monkeys exhibited similar clinicopathological characteristics to the human disease and was useful as an experimental model. WHAT IS KNOWN ALREADY: The prevalence of endometriosis in autopsied cynomolgus monkeys (Macaca fascicularis) in a breeding colony was reported to be 28...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29669005/fertility-and-neonatal-outcomes-of-embryos-achieving-blastulation-on-day-7-are-they-of-clinical-value
#6
Tong Du, Yun Wang, Yong Fan, Shiyi Zhang, Zhiguang Yan, Weina Yu, Qianwen Xi, Qiuju Chen, Ben W Mol, Qifeng Lyu, Yanping Kuang
STUDY QUESTION: Is transferring embryos that achieve blastulation on Day 7 effective and safe? SUMMARY ANSWER: Embryos that achieve blastulation on Day 7 resulted in clinically relevant rates of clinical pregnancy (32.5%) and live birth (25.2%), and newborns have a similar risk of low birth weight, congenital malformations or early neonatal death compared with those derived from Days 5 and 6 blastocysts. WHAT IS KNOWN ALREADY: Potential advantages of blastocyst transfer over cleavage embryo transfer have led to a shift toward the former in IVF practice...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29668891/maternal-polycystic-ovarian-syndrome-and-early-offspring-development
#7
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney, Edwina H Yeung
STUDY QUESTION: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring? SUMMARY ANSWER: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ). WHAT IS KNOWN ALREADY: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659848/why-after-50-years-of-effective-contraception-do-we-still-have-unintended-pregnancy-a-european-perspective
#8
(no author information available yet)
Unintended pregnancy is a public health concern throughout Europe. There is no common definition and no standard way to measure unintended pregnancy. Identifying unintended births is difficult and prevalence estimates vary depending on how and when the question is asked. Abortion rates are not a proxy and are themselves notoriously inaccurate. An estimated 34% (in Western Europe) to 54% (in Eastern Europe) of pregnancies are unintended. The determinants of unintended pregnancy are the length of the reproductive span and exposure to the risk of conception; the desired number of children and contraceptive use and effectiveness...
April 11, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659832/average-sperm-count-remains-unchanged-despite-reduction-in-maternal-smoking-results-from-a-large-cross-sectional-study-with-annual-investigations-over-21-years
#9
L Priskorn, L Nordkap, A K Bang, M Krause, S A Holmboe, D L Egeberg Palme, S B Winge, N Mørup, E Carlsen, U N Joensen, M Blomberg Jensen, K M Main, A Juul, N E Skakkebaek, T K Jensen, N Jørgensen
STUDY QUESTION: How are temporal trends in lifestyle factors, including exposure to maternal smoking in utero, associated to semen quality in young men from the general population? SUMMARY ANSWER: Exposure to maternal smoking was associated with lower sperm counts but no overall increase in sperm counts was observed during the study period despite a decrease in this exposure. WHAT IS KNOWN ALREADY: Meta-analyses suggest a continuous decline in semen quality but few studies have investigated temporal trends in unselected populations recruited and analysed with the same protocol over a long period and none have studied simultaneous trends in lifestyle factors...
April 11, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29648647/a-prospective-study-of-physical-activity-and-fecundability-in-women-with-a-history-of-pregnancy-loss
#10
Lindsey M Russo, Brian W Whitcomb, Sunni L Mumford, Marquis Hawkins, Rose G Radin, Karen C Schliep, Robert M Silver, Neil J Perkins, Keewan Kim, Ukpebo R Omosigho, Daniel L Kuhr, Tiffany L Holland, Lindsey A Sjaarda, Enrique F Schisterman
STUDY QUESTION: Is physical activity (PA) associated with fecundability in women with a history of prior pregnancy loss? SUMMARY ANSWER: Higher fecundability was related to walking among overweight/obese women and to vigorous PA in women overall. WHAT IS KNOWN ALREADY: PA may influence fecundability through altered endocrine function. Studies evaluating this association have primarily utilized Internet-based recruitment and self-report for pregnancy assessment and have yielded conflicting results...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29648645/does-human-endometrial-lgr5-gene-expression-suggest-the-existence-of-another-hormonally-regulated-epithelial-stem-cell-niche
#11
N Tempest, A M Baker, N A Wright, D K Hapangama
STUDY QUESTION: Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated? SUMMARY ANSWER: LGR5 expressing cells are not limited to the postulated stem cell niche but LGR5 expression is hormonally regulated. WHAT IS KNOWN ALREADY: The human endometrium is a highly regenerative tissue; however, endometrial epithelial stem cell markers are yet to be confirmed...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29648640/should-extended-blastocyst-culture-include-day-7
#12
Elizabeth R Hammond, Lynsey M Cree, Dean E Morbeck
Extended culture to the blastocyst stage is widely practised, improving embryo selection and promoting single embryo transfer. Selection of useable blastocysts typically occurs on Days 5 and 6 of embryo culture. Embryos not suitable for transfer, biopsy or cryopreservation after Day 6 are routinely discarded. Some embryos develop at a slower rate, however, forming blastocysts on Day 7 of culture. Day 7 blastocysts can be viable, they can be of top morphological grade, euploid and result in a healthy live birth...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29635630/creatine-enhances-the-duration-of-sperm-capacitation-a-novel-factor-for-improving-in-vitro-fertilization-with-small-numbers-of-sperm
#13
Takashi Umehara, Tomoko Kawai, Masaaki Goto, JoAnne S Richards, Masayuki Shimada
STUDY QUESTION: Why are many sperm required for successful fertilization of oocytes in vitro, even though fertilization occurs in vivo when only a few sperm reach the oocyte? SUMMARY ANSWER: Creatine produced in the ovary promotes efficient fertilization in vivo; however, in vitro, creatine is not contained in the in vitro fertilization (IVF) medium. WHAT IS KNOWN ALREADY: The IVF medium enables capacitation of sperm. However, the IVF medium does not fully mimic the in vivo environment during fertilization...
April 9, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29635371/two-step-transplantation-with-adipose-tissue-derived-stem-cells-increases-follicle-survival-by-enhancing-vascularization-in-xenografted-frozen-thawed-human-ovarian-tissue
#14
D D Manavella, L Cacciottola, S Pommé, C M Desmet, B F Jordan, J Donnez, C A Amorim, M M Dolmans
STUDY QUESTION: Do adipose tissue-derived stem cells (ASCs) enhance vascularization and follicle survival in xenografted ovarian tissue using a two-step transplantation approach? SUMMARY ANSWER: Higher rates of oxygenation and vascularization of ovarian tissue, as well as increased follicle survival rates, were detected in the early post-grafting period. WHAT IS KNOWN ALREADY: ASCs have multilineage differentiation potential, proangiogenic properties and enhance vascularization in a peritoneal grafting site...
April 9, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29635353/the-relation-of-age-at-menarche-with-age-at-natural-menopause-a-population-study-of-336-788-women-in-norway
#15
E K Bjelland, S Hofvind, L Byberg, A Eskild
STUDY QUESTION: Is age at menarche associated with age at menopause or with duration of the reproductive period (interval between menarche and menopause)? SUMMARY ANSWER: The association of age at menarche with age at menopause was weak and non-linear, and the duration of the reproductive period decreased by increasing age at menarche. WHAT IS KNOWN ALREADY: It remains uncertain whether age at menarche is associated with age at menopause. Some studies report that women with early menarche also have early menopause...
April 9, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659847/follicle-growth-and-endocrine-dynamics-in-women-with-spontaneous-luteinized-unruptured-follicles-versus-ovulation
#16
S T Bashir, A R Baerwald, M O Gastal, R A Pierson, E L Gastal
STUDY QUESTION: Do growth patterns and endocrine profiles differ between ovulatory follicles (OvFs) and luteinized unruptured follicles (LUFs) in women? SUMMARY ANSWER: Growth rates, diameters and associated endocrine profiles differed between OvFs and LUFs in unstimulated cycles. WHAT IS KNOWN ALREADY: Two-three waves of antral follicles develop during the menstrual cycle in ovulatory women of reproductive age, with the second or third wave terminating in ovulation...
April 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659829/take-a-break
#17
(no author information available yet)
No abstract text is available yet for this article.
April 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659835/anti-m%C3%A3-llerian-hormone-levels-and-incidence-of-early-natural-menopause-in-a-prospective-study
#18
Elizabeth R Bertone-Johnson, JoAnn E Manson, Alexandra C Purdue-Smithe, Anne Z Steiner, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Brian W Whitcomb
STUDY QUESTION: Are anti-Müllerian hormone (AMH) levels assessed in women aged 32-44 associated with risk of incident early natural menopause? SUMMARY ANSWER: We observed strong, significant associations between lower AMH levels and higher risk of early menopause. WHAT IS KNOWN ALREADY: The ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659827/a-mei1-homozygous-missense-mutation-associated-with-meiotic-arrest-in-a-consanguineous-family
#19
M Ben Khelifa, F Ghieh, R Boudjenah, C Hue, D Fauvert, R Dard, H J Garchon, F Vialard
Although meiotic arrest in males is observed in about 25% of azoospermic patients, pure homogeneous arrest in all seminiferous tubules is less frequent, and may be due to mutation of a single gene. However, given the large number of genes involved in meiosis, this gives rises to extensive genetic heterogeneity. Only two genetic abnormalities have been reported on a regular basis: the X-linked exonic TEX11 deletion, and the AZFb microdeletion on the Y chromosome. Other single gene defects were private and found in consanguineous families...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659826/association-between-ambient-air-pollution-and-pregnancy-rate-in-women-who-underwent-ivf
#20
S A Choe, Y B Jun, W S Lee, T K Yoon, S Y Kim
STUDY QUESTION: Are the concentrations of five criteria air pollutants associated with probabilities of biochemical pregnancy loss and intrauterine pregnancy in women? SUMMARY ANSWER: Increased concentrations of ambient particulate matter (PM10), nitrogen dioxide (NO2), carbon monoxide (CO) during controlled ovarian stimulation (COS) and after embryo transfer were associated with a decreased probability of intrauterine pregnancy. WHAT IS KNOWN ALREADY: Exposure to high ambient air pollution was suggested to be associated with low fertility and high early pregnancy loss in women...
April 5, 2018: Human Reproduction
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