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Human Reproduction

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https://www.readbyqxmd.com/read/29931333/reply-the-big-freeze-freeze-all-should-not-be-used-for-everyone
#1
Qianqian Zhu, Qiuju Chen, Li Wang, Xuefeng Lu, Qifeng Lyu, Yun Wang, Yanping Kuang
No abstract text is available yet for this article.
June 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912414/peroxiredoxin-6-is-the-primary-antioxidant-enzyme-for-the-maintenance-of-viability-and-dna-integrity-in-human-spermatozoa
#2
Maria C Fernandez, Cristian O'Flaherty
STUDY QUESTION: Are all components of the peroxiredoxins (PRDXs) system important to control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in spermatozoa? SUMMARY ANSWER: PRDX6 is the primary player of the PRDXs system for maintaining viability and DNA integrity in human spermatozoa. WHAT IS KNOWN ALREADY: Mammalian spermatozoa are sensitive to high levels of ROS and PRDXs are antioxidant enzymes proven to control the levels of ROS generated during sperm capacitation to avoid oxidative damage in the spermatozoon...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912389/the-big-freeze-freeze-all-should-not-be-used-for-everyone
#3
Matheus Roque, Thor Haahr, Sandro C Esteves, Peter Humaidan
No abstract text is available yet for this article.
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912377/novel-homozygous-nonsense-mutations-in-lhcgr-lead-to-empty-follicle-syndrome-and-46-xy-disorder-of-sex-development
#4
C Chen, X Xu, L Kong, P Li, F Zhou, S Zhao, X Xin, J Tan, X Zhang
Empty follicle syndrome (EFS) is a disorder associated with female infertility and presents as a complete failure to retrieve oocytes during ART cycles despite normal follicle development and careful aspiration. To date, only two EFS cases have been reported with homozygous missense mutations in the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) gene, and both cases showed normal estradiol (E2) production during ovulation induction. The molecular genetic mechanisms of EFS remain unknown. Herein, we report two novel homozygous inactivating LHCGR mutations, c...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912374/luteal-phase-anovulatory-follicles-result-in-the-production-of-competent-oocytes-intra-patient-paired-case-control-study-comparing-follicular-versus-luteal-phase-stimulations-in-the-same-ovarian-cycle
#5
Danilo Cimadomo, Alberto Vaiarelli, Silvia Colamaria, Elisabetta Trabucco, Carlo Alviggi, Roberta Venturella, Erminia Alviggi, Ramona Carmelo, Laura Rienzi, Filippo Maria Ubaldi
STUDY QUESTION: Are the mean numbers of blastocysts obtained from sibling cohorts of oocytes recruited after follicular phase and luteal phase stimulations (FPS and LPS) in the same ovarian cycle similar? SUMMARY ANSWER: The cohorts of oocytes obtained after LPS are larger than their paired-FPS-derived cohorts and show a comparable competence, thus resulting in a larger mean number of blastocysts. WHAT IS KNOWN ALREADY: Three theories of follicle recruitment have been postulated to date: (i) the 'continuous recruitment' theory, (ii) the 'single recruitment episode' theory and (iii) the 'wave' theory...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912343/impact-on-testicular-function-of-a-single-ablative-activity-of-3-7-gbq-radioactive-iodine-for-differentiated-thyroid-carcinoma
#6
N Bourcigaux, C Rubino, I Berthaud, M E Toubert, B Donadille, L Leenhardt, I Petrot-Keller, S Brailly-Tabard, J Fromigué, F de Vathaire, T Simon, J P Siffroi, M Schlumberger, P Bouchard, S Christin-Maitre
STUDY QUESTION: What are the consequences of radioactive iodine (RAI) therapy for testicular function? SUMMARY ANSWER: A single activity of 3.7 GBq RAI for differentiated thyroid carcinoma (DTC) treatment in young men transiently altered Sertoli cell function and induced sperm chromosomal abnormalities. WHAT IS KNOWN ALREADY: Few studies, mainly retrospective, have reported the potential impacts of RAI on endocrine and exocrine testicular function...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912341/on-the-pasta-theory-of-reproductive-research
#7
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912336/reproductive-life-in-women-with-celiac-disease-a-nationwide-population-based-matched-cohort-study
#8
L Grode, B H Bech, O Plana-Ripoll, M Bliddal, I E Agerholm, P Humaidan, C H Ramlau-Hansen
STUDY QUESTION: How does celiac disease (CD) influence women's reproductive life, both prior to and after the diagnosis? SUMMARY ANSWER: Prior to the diagnosis of CD, an increased risk of adverse pregnancy outcomes was seen, whereas after the diagnosis, no influence on reproductive outcomes was found. WHAT IS KNOWN ALREADY: CD has been associated with several conditions influencing female reproduction and pregnancy outcomes including spontaneous abortion and stillbirth...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912328/the-impact-of-cancer-on-subsequent-chance-of-pregnancy-a-population-based-analysis
#9
Richard A Anderson, David H Brewster, Rachael Wood, Sian Nowell, Colin Fischbacher, Tom W Kelsey, W Hamish B Wallace
STUDY QUESTION: What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy? SUMMARY ANSWER: Cancer survivors achieved fewer pregnancies across all cancer types, and the chance of achieving a first pregnancy was also lower. WHAT IS KNOWN ALREADY: The diagnosis and treatment of cancer in young females may be associated with reduced fertility but the true pregnancy deficit in a population is unknown. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study relating first incident cancer diagnosed between 1981 and 2012 to subsequent pregnancy in all female patients in Scotland aged 39 years or less at cancer diagnosis (n = 23 201)...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29912323/decreased-clinical-pregnancy-and-live-birth-rates-after-short-interval-from-delivery-to-subsequent-assisted-reproductive-treatment-cycle
#10
Molly M Quinn, Mitchell P Rosen, Isabel Elaine Allen, Heather G Huddleston, Marcelle I Cedars, Victor Y Fujimoto
STUDY QUESTION: Does the interval from delivery to initiation of a subsequent ART treatment cycle impact clinical pregnancy or live birth rates? SUMMARY ANSWER: An interval from delivery to treatment start of <6 months or ≥24 months is associated with decreased likelihood of clinical pregnancy and live birth. WHAT IS KNOWN ALREADY: Short interpregnancy intervals are associated with poor obstetric outcomes in the naturally conceiving population prompting birth spacing recommendations of 18-24 months from international organizations...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29897458/increased-aif-1-mediated-tnf-%C3%AE-expression-during-implantation-phase-in-ivf-cycles-with-gnrh-antagonist-protocol
#11
Bufang Xu, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Feng Guo, Chenchen Si, Peter C K Leung, Aijun Zhang
STUDY QUESTION: Is allograft inflammatory factor-1 (AIF-1), a cytokine associated with inflammation and allograft rejection, aberrantly elevated in in vitro fertilization (IVF) cycles with gonadotropin-releasing hormone (GnRH) antagonist protocol with potential effects on endometrial receptivity? SUMMARY ANSWER: Our findings indicated AIF-1 is increased in IVF cycles with GnRH antagonist protocol and mediates greater TNF-α expression during implantation phase, which may be unfavorable for embryo implantation...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29897449/icsi-does-not-increase-the-cumulative-live-birth-rate-in-non-male-factor-infertility
#12
Z Li, A Y Wang, M Bowman, K Hammarberg, C Farquhar, L Johnson, N Safi, E A Sullivan
STUDY QUESTION: What is the cumulative live birth rate following ICSI cycles compared with IVF cycles for couples with non-male factor infertility? SUMMARY ANSWER: ICSI resulted in a similar cumulative live birth rate compared with IVF for couples with non-male factor infertility. WHAT IS KNOWN ALREADY: The ICSI procedure was developed for couples with male factor infertility. There has been an increased use of ICSI regardless of the cause of infertility...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29897442/latent-genital-tuberculosis-adversely-affects-the-ovarian-reserve-in-infertile-women
#13
P R Jirge, S M Chougule, A Keni, S Kumar, D Modi
STUDY QUESTION: What is the effect of latent genital tuberculosis (GTB) on ovarian reserve in infertile women? SUMMARY ANSWER: Women with latent GTB have lower ovarian reserves and yield lower numbers of oocytes in IVF. WHAT IS KNOWN ALREADY: Limited evidence suggests that women with GTB may have a low ovarian reserve. Infertile women have a high incidence of latent GTB and treatment improves fertility outcomes. STUDY DESIGN, SIZE, DURATION: This prospective study from February 2013 to January 2016 compared 431 infertile women diagnosed with latent GTB (Group I) to 453 infertile women without latent GTB (Group II)...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29860321/premature-ovarian-insufficiency-and-early-depletion-of-the-ovarian-reserve-in-the-monogenic-mulibrey-nanism-disorder
#14
Susann Karlberg, Aila Tiitinen, Henrik Alfthan, Marita Lipsanen-Nyman
STUDY QUESTION: What is the timing of onset and clinical course of premature ovarian insufficiency (POI) in patients with Mulibrey nanism (MUL), a monogenic disorder caused by mutations of the peroxisomal TRIM37 gene? SUMMARY ANSWER: The number of ovarian follicles is highly reduced already in infant and young MUL girls and the majority of them will have early depletion of follicles resulting in clinical and biochemical signs of POI. WHAT IS KNOWN ALREADY: Both female and male patients with MUL show failure of sexual maturation, signs of hypogonadism and infertility...
June 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29850888/mutation-specific-effects-in-germline-transmission-of-pathogenic-mtdna-variants
#15
Auke B C Otten, Suzanne C E H Sallevelt, Phillippa J Carling, Joseph C F M Dreesen, Marion Drüsedau, Sabine Spierts, Aimee D C Paulussen, Christine E M de Die-Smulders, Mary Herbert, Patrick F Chinnery, David C Samuels, Patrick Lindsey, Hubert J M Smeets
STUDY QUESTION: Does germline selection (besides random genetic drift) play a role during the transmission of heteroplasmic pathogenic mitochondrial DNA (mtDNA) mutations in humans? SUMMARY ANSWER: We conclude that inheritance of mtDNA is mutation-specific and governed by a combination of random genetic drift and negative and/or positive selection. WHAT IS KNOWN ALREADY: mtDNA inherits maternally through a genetic bottleneck, but the underlying mechanisms are largely unknown...
May 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29850857/testicular-microbiome-in-azoospermic-men-first-evidence-of-the-impact-of-an-altered-microenvironment
#16
Massimo Alfano, Roberto Ferrarese, Irene Locatelli, Eugenio Ventimiglia, Silvia Ippolito, Pierangela Gallina, Daniela Cesana, Filippo Canducci, Luca Pagliardini, Paola Viganò, Massimo Clementi, Manuela Nebuloni, Francesco Montorsi, Andrea Salonia
STUDY QUESTION: Given the relevant role of the extracellular microenvironment in regulating tissue homeostasis, is testicular bacterial microbiome (BM) associated with germ cell aplasia in idiopathic non-obstructive azoospermia (iNOA)? SUMMARY ANSWER: A steady increase of dysbiosis was observed among testis with normal spermatogenesis vs. iNOA with positive sperm retrieval and iNOA with complete germ cell aplasia. WHAT IS KNOWN ALREADY: Tissue-associated BM has been reported to be a biologically important extracellular microenvironment component for numerous body habitats, but not yet for the human testis...
May 30, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29796631/chromosomal-mosaicism-in-human-blastocysts-the-ultimate-challenge-of-preimplantation-genetic-testing
#17
M Popovic, A Dheedene, C Christodoulou, J Taelman, L Dhaenens, F Van Nieuwerburgh, D Deforce, E Van den Abbeel, P De Sutter, B Menten, B Heindryckx
STUDY QUESTION: To what extent does a trophectoderm (TE) biopsy reliably reflect the chromosomal constitution of the inner cell mass (ICM) in human blastocysts? SUMMARY ANSWER: Concordance between TE and ICM was established in 62.1% of the embryos analysed. WHAT IS KNOWN ALREADY: Next generation sequencing (NGS) platforms have recently been optimised for preimplantation genetic testing for aneuploidies (PGT-A). However, higher sensitivity has led to an increase in reports of chromosomal mosaicism within a single TE biopsy...
May 23, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29796614/anxiety-and-depressive-symptoms-and-stress-biomarkers-in-pregnant-women-after-in-vitro-fertilization-a-prospective-cohort-study
#18
Ana García-Blanco, Vicente Diago, David Hervás, Farah Ghosn, Máximo Vento, Consuelo Cháfer-Pericás
STUDY QUESTION: Does in vitro fertilization (IVF) affect the course of anxiety and depressive symptoms as well as physiological stress from pregnancy to postpartum period? SUMMARY ANSWER: IVF mothers have more anxiety symptoms and higher stress biomarker levels but fewer depression symptoms than natural conception mothers at the third trimester of pregnancy, but these differences are negligible during postpartum period. WHAT IS KNOWN ALREADY: Cross-sectional studies have found an association between IVF and high stress levels during the prenatal period...
May 23, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29788175/prevalence-of-xxy-karyotypes-in-human-blastocysts-multicentre-data-from-7549-trophectoderm-biopsies-obtained-during-preimplantation-genetic-testing-cycles-in-ivf
#19
Rossella Mazzilli, Danilo Cimadomo, Laura Rienzi, Antonio Capalbo, Paolo Emanuele Levi Setti, Claudia Livi, Damiano Vizziello, Carlo Foresta, Alberto Ferlin, Filippo Maria Ubaldi
STUDY QUESTION: Which is the prevalence of a 47,XXY karyotype in human blastocysts biopsied during preimplantation genetic testing for aneuploidies (PGT-A) cycles? SUMMARY ANSWER: The prevalence of a 47,XXY karyotype amongst male blastocysts without autosomal aneuploides is ~1%. WHAT IS KNOWN ALREADY: The prevalence of Klinefelter syndrome is estimated as 0.1-0.2% in male newborns. However, the KS phenotype is extremely variable and there are men with a 47,XXY karyotype and less evident signs, who may go undetected...
May 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29788467/reply-an-informed-decision-between-cleavage-stage-and-blastocyst-stage-transfers-in-ivf-requires-data-on-the-transfers-of-frozen-thawed-embryos
#20
Lanlin Yang, Ge Lin
No abstract text is available yet for this article.
May 18, 2018: Human Reproduction
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