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Human Reproduction

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https://www.readbyqxmd.com/read/29462326/secreted-frizzled-related-protein-2-sfrp2-expression-promotes-lesion-proliferation-via-canonical-wnt-signaling-and-indicates-lesion-borders-in-extraovarian-endometriosis
#1
T Heinosalo, M Gabriel, L Kallio, P Adhikari, K Huhtinen, T D Laajala, E Kaikkonen, A Mehmood, P Suvitie, H Kujari, T Aittokallio, A Perheentupa, M Poutanen
STUDY QUESTION: What is the role of SFRP2 in endometriosis? SUMMARY ANSWER: SFRP2 acts as a canonical WNT/CTNNB1 signaling agonist in endometriosis, regulating endometriosis lesion growth and indicating endometriosis lesion borders together with CTNNB1 (also known as beta catenin). WHAT IS KNOWN ALREADY: Endometriosis is a common, chronic disease that affects women of reproductive age, causing pain and infertility, and has significant economic impact on national health systems...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29462324/endometriosis-induces-gut-microbiota-alterations-in-mice
#2
Ming Yuan, Dong Li, Zhe Zhang, Huihui Sun, Min An, Guoyun Wang
STUDY QUESTION: What happens to the gut microbiota during development of murine endometriosis? SUMMARY ANSWER: Mice with the persistence of endometrial lesions for 42 days develop a distinct composition of gut microbiota. WHAT IS KNOWN ALREADY: Disorders in the immune system play fundamental roles in changing the intestinal microbiota. No study has used high-throughput DNA sequencing to show how endometriosis changes the gut microbiota, although endometriosis is accompanied by abnormal cytokine expression and immune cell dysfunction...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29462319/cell-free-fetal-dna-testing-in-singleton-ivf-conceptions
#3
Timothy J Lee, Daniel L Rolnik, Melody A Menezes, Andrew C McLennan, Fabricio da Silva Costa
STUDY QUESTION: Are fetal fraction, test failure rate and positive predictive value (PPV) of cell-free fetal DNA (cffDNA) testing different in singleton IVF conceptions compared to spontaneous conceptions? SUMMARY ANSWER: Fetal fraction is significantly lower; test failure rate is higher and PPV of cffDNA testing is lower in singleton pregnancies conceived by IVF than those conceived spontaneously. WHAT IS ALREADY KNOWN: cffDNA testing, which analyses circulating cffDNA in maternal blood, has very high accuracy for detection of trisomy 21 in the general obstetric population...
February 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452422/asynchronous-and-pathological-windows-of-implantation-two-causes-of-recurrent-implantation-failure
#4
P Sebastian-Leon, N Garrido, J Remohí, A Pellicer, P Diaz-Gimeno
STUDY QUESTION: Is endometrial recurrent implantation failure (RIF) only a matter of an asynchronous (displaced) window of implantation (WOI), or could it also be a pathological (disrupted) WOI? SUMMARY ANSWER: Our predictive results demonstrate that both displaced and disrupted WOIs exist and can present independently or together in the same RIF patient. WHAT IS KNOWN ALREADY: Since 2002, many gene expression signatures associated with endometrial receptivity and RIF have been described...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452389/parity-associated-with-telomere-length-among-us-reproductive-age-women
#5
A Z Pollack, K Rivers, K A Ahrens
STUDY QUESTION: Is telomere length related to parity among a nationally representative sample of US reproductive age women? SUMMARY ANSWER: History of live birth was associated with shorter telomere length. WHAT IS KNOWN ALREADY: Shorter telomeres have been linked with a range of chronic health conditions and mortality and parity has been associated with health indicators. However, there is a lack of research on how parity relates to telomere length...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452353/a-diagnostic-germ-cell-score-for-immature-testicular-tissue-at-risk-of-germ-cell-loss
#6
L Heckmann, D Langenstroth-Röwer, T Pock, J Wistuba, J-B Stukenborg, M Zitzmann, S Kliesch, S Schlatt, N Neuhaus
STUDY QUESTION: Can a systematic scoring procedure provide crucial information on the status of highly heterogeneous immature human testicular tissues in the context of cryopreservation for fertility preservation? SUMMARY ANSWER: We developed a systematic histological score as a novel diagnostic tool which differentiates the patient cohort according to the status of germ cell differentiation and number of spermatogonia (normal, diminished and absent), and which could be relevant in the fertility clinic...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29447367/endometrial-natural-killer-nk-cells-reveal-a-tissue-specific-receptor-repertoire
#7
D Feyaerts, T Kuret, B van Cranenbroek, S van der Zeeuw-Hingrez, O W H van der Heijden, A van der Meer, I Joosten, R G van der Molen
STUDY QUESTION: Is the natural killer (NK) cell receptor repertoire of endometrial NK (eNK) cells tissue-specific? SUMMARY ANSWER: The NK cell receptor (NKR) expression profile in pre-pregnancy endometrium appears to have a unique tissue-specific phenotype, different from that found in NK cells in peripheral blood, suggesting that these cells are finely tuned towards the reception of an allogeneic fetus. WHAT IS KNOWN ALREADY: NK cells are important for successful pregnancy...
February 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29432583/the-clinical-utility-of-pgd-with-hla-matching-a-collaborative-multi-centre-eshre-study
#8
G Kakourou, S Kahraman, G C Ekmekci, H A Tac, G Kourlaba, E Kourkouni, A Cervero Sanz, J Martin, H Malmgren, C Giménez, V Gold, F Carvalho, C Billi, J F C Chow, X Vendrell, G Kokkali, J Liss, J Steffann, J Traeger-Synodinos
STUDY QUESTION: Has PGD-HLA been successful relative to diagnostic and clinical efficacy? SUMMARY ANSWER: The diagnostic efficacy of PGD-HLA protocols was found lower in this study in comparison to published PGD-HLA protocols and to that reported for general PGD by ESHRE (78.5 vs 94.1% and vs 92.6%, respectively), while the clinical efficacy has proven very difficult to assess due to inadequate follow-up of both the ART/PGD and HSCT procedure outcomes. WHAT IS KNOWN ALREADY: The first clinical cases for PGD-HLA were reported in 2001...
February 8, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29432528/reply-false-positive-blood-hcg-test-following-corifollitropin-alfa-injection
#9
Richard Gersh
No abstract text is available yet for this article.
February 8, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29425332/association-between-use-of-phthalate-containing-medication-and-semen-quality-among-men-in-couples-referred-for-assisted-reproduction
#10
A Broe, A Pottegård, J Hallas, T P Ahern, J Fedder, P Damkier
STUDY QUESTION: Does phthalate exposure from prescription drugs affect semen quality? SUMMARY ANSWER: Exposure to phthalate-containing drugs is associated with poor semen quality. WHAT IS KNOWN ALREADY: Phthalates and their metabolites have been shown to disrupt the hormone signalling in animal studies. One study has shown associations between medicinal phthalate exposure and poor semen quality, suggesting similar effects in humans. STUDY DESIGN, SIZE, DURATION: We included 18 515 males with poor semen quality (cases) and 31 063 males with normal semen quality (controls) registered in the Danish IVF Registry from 2006 to 2016...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29425298/-man-up-the-importance-and-strategy-for-placing-male-reproductive-health-centre-stage-in-the-political-and-research-agenda
#11
Christopher L R Barratt, Christopher J De Jonge, Richard M Sharpe
Approximately 1 in 20 young men today have sperm counts low enough to impair fertility, whereas this may not have been the case historically. The cause(s) of such a decline in male reproductive health is unknown, despite it being a global health issue. Concomitantly, little progress has been made in answering fundamental questions in andrology or in developing new diagnostic tools or alternative management strategies to ICSI in infertile men. We advocate formulation of a detailed roadmap for male reproductive health to facilitate development of a research agenda that highlights the present unmet needs and key unanswered questions, and seeks to deliver effective funding and investment to address them...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29425289/the-numbers-of-2-5-and-6-9-mm-ovarian-follicles-are-inversely-correlated-in-both-normal-women-and-in-polycystic-ovary-syndrome-patients-what-is-the-missing-link
#12
M Peigné, S Catteau-Jonard, G Robin, A Dumont, P Pigny, D Dewailly
STUDY QUESTION: Is the negative correlation between the numbers of 2-5 and 6-9 mm follicles influenced by ovarian and/or metabolic parameter(s) in young control women and in patients with polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER: Our study confirmed that the negative correlation between numbers of follicles sized 2-5 and 6-9 mm was stronger in PCOS than in young control women and was not linked to any ovarian or metabolic parameter. WHAT IS KNOWN ALREADY: Previous reports described a direct negative correlation between the number of small antral follicles (2-5 mm) and large antral follicle (6-9 mm) during the early follicular phase (cycle Days 2-5) in normal and PCOS women...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29425284/chromosomal-instability-in-women-with-primary-ovarian-insufficiency
#13
Sunita Katari, Mahmoud Aarabi, Angela Kintigh, Susan Mann, Svetlana A Yatsenko, Joseph S Sanfilippo, Anthony J Zeleznik, Aleksandar Rajkovic
STUDY QUESTION: What is the prevalence of somatic chromosomal instability among women with idiopathic primary ovarian insufficiency (POI)? SUMMARY ANSWER: A subset of women with idiopathic POI may have functional impairment in DNA repair leading to chromosomal instability in their soma. WHAT IS KNOWN ALREADY: The formation and repair of DNA double-strand breaks during meiotic recombination are fundamental processes of gametogenesis. Oocytes with compromised DNA integrity are susceptible to apoptosis which could trigger premature ovarian aging and accelerated wastage of the human follicle reserve...
February 7, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29420768/which-cell-defines-endometriosis
#14
Ivo Brosens, Patrick Puttemans, Giuseppe Benagiano
No abstract text is available yet for this article.
February 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29420752/the-significance-of-human-spermatozoa-vacuoles-can-be-elucidated-by-a-novel-procedure-of-array-comparative-genomic-hybridization
#15
Arie Berkovitz, Yaron Dekel, Revital Goldstein, Shhadeh Bsoul, Yossy Machluf, Dani Bercovich
STUDY QUESTION: Is there an association between spermatozoon genomic stability and vacuolar morphology and location? SUMMARY ANSWER: The genomic stability of spermatozoa is associated with specific characteristics of vacuolar morphology (depth) and location (cellular compartment, i.e. nucleus and equatorial region). WHAT IS KNOWN ALREADY: Genetic anomalies in sperm are correlated with semen abnormalities, yet the advantage of morphologically based selection of spermatozoa for IVF according to current criteria is controversial...
February 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29420711/fibrogenesis-resulting-from-cyclic-bleeding-the-holy-grail-of-the-natural-history-of-ectopic-endometrium
#16
Sun-Wei Guo
No abstract text is available yet for this article.
February 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29415225/reply-is-single-ovary-a-detrimental-factor-for-live-birth-rate-in-ivf-understanding-the-real-clinical-effect-of-unilateral-oophorectomy
#17
Tekla Lind, Jan I Olofsson, Lars Berglund, Kenny Rodriguez-Wallberg
No abstract text is available yet for this article.
February 3, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29408962/ibuprofen-is-deleterious-for-the-development-of-first-trimester-human-fetal-ovary-ex-vivo
#18
S Leverrier-Penna, R T Mitchell, E Becker, L Lecante, M Ben Maamar, N Homer, V Lavoué, D M Kristensen, N Dejucq-Rainsford, B Jégou, S Mazaud-Guittot
STUDY QUESTION: Does ibuprofen use during the first trimester of pregnancy interfere with the development of the human fetal ovary? SUMMARY ANSWER: In human fetuses, ibuprofen exposure is deleterious for ovarian germ cells. WHAT IS KNOWN ALREADY: In utero stages of ovarian development define the future reproductive capacity of a woman. In rodents, analgesics can impair the development of the fetal ovary leading to early onset of fertility failure...
February 2, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29394365/live-birth-rate-following-frozen-thawed-blastocyst-transfer-is-higher-with-blastocysts-expanded-on-day-5-than-on-day-6
#19
Lucile Ferreux, Mathilde Bourdon, Amira Sallem, Pietro Santulli, Virginie Barraud-Lange, Nathalie Le Foll, Chloé Maignien, Charles Chapron, Dominique de Ziegler, Jean-Philippe Wolf, Khaled Pocate-Cheriet
STUDY QUESTION: The aim of this study was to evaluate the live birth rate (LBR) after frozen-thawed Day 5 (D5) and Day 6 (D6) blastocyst transfers. SUMMARY ANSWER: LBR following frozen-thawed blastocyst transfer is significantly lower with D6 than with D5 blastocyst regardless of embryo quality. WHAT IS KNOWN ALREADY: During fresh embryo transfer cycles, pregnancy rates (PR) are significantly higher when transferring blastocysts expanded on D5 compared with slow developing blastocysts (D6)...
February 2, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29401296/changes-in-keratin-8-18-expression-in-human-granulosa-cell-lineage-are-associated-to-cell-death-survival-events-potential-implications-for-the-maintenance-of-the-ovarian-reserve
#20
F Gaytan, C Morales, J Roa, M Tena-Sempere
STUDY QUESTION: Is keratin 8/18 (K8/K18) expression linked to cell death/survival events in the human granulosa cell lineage? SUMMARY ANSWER: A close association exists between changes in K8/K18 expression and cell death/survival events along the human granulosa cell lineage lifespan. WHAT IS KNOWN ALREADY: In addition to their structural and mechanical functions, K8/K18 play essential roles regulating cell death, survival and differentiation in several non-gonadal epithelial tissues...
February 1, 2018: Human Reproduction
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