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Human Pathology

Zhenying Guo, Ricardo V Lloyd
No abstract text is available yet for this article.
October 13, 2016: Human Pathology
Arnaud Uguen
No abstract text is available yet for this article.
October 13, 2016: Human Pathology
Michael Michal, Alena Skálová, Dmitry V Kazakov, Květoslava Pecková, Filip Heidenreich, Petr Grossmann, Michal Michal
We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces which were invariably surrounded by the OS. The cystic spaces were lined by flat, cuboidal or columnar epithelial cells, in most parts showing mucinous differentiation. The epithelial lining of the cysts strongly expressed cytokeratins AE1-3, CK7, CK8, CK18, CK19, EMA and S100 protein...
October 13, 2016: Human Pathology
Yoshiki Nando, Jiro Watari, Chiyomi Ito, Ken Hara, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Nagahide Matsubara, Naohiro Tomita, Seiichi Hirota, Hiroto Miwa
It is recommended that small (6-10 mm) lesions be treated with endoscopic resection (ER), while diminutive (≤ 5 mm) lesions are not currently an indication for ER according to the Japanese guidelines. The aim of this study was to evaluate the molecular alterations, and therefore treatment indications, in diminutive vs. small tubular adenoma (TA). We prospectively analyzed genetic instability, including microsatellite instability (MSI) and loss of heterozygosity, methylation status, KRAS/BRAF mutations, and Ki-67 staining in 96 TAs without a villous component...
October 13, 2016: Human Pathology
Cunxian Zhang, C James Sung, M Ruhul Quddus, Rochelle A Simon, Tarek Jazaerly, W Dwayne Lawrence
Ovarian hyperthecosis, a source of estrogen, may occur in postmenopausal women. In this study, we evaluated the possible association of ovarian hyperthecosis with endometrial polyp, endometrial hyperplasia, and endometrioid adenocarcinoma in postmenopausal women. Our study consisted of 238 postmenopausal women: 108 with endometrioid adenocarcinoma and 130 without endometrial carcinoma. The International Federation of Gynecology and Obstetrics system was used to grade endometrioid adenocarcinoma. Within the endometrioid adenocarcinoma cases, 48 (44...
October 13, 2016: Human Pathology
Alberto M Marchevsky, Ann E Walts
The checkpoint protein programmed cell death ligand-1 protein (PD-L1) binds to its receptor (PD-1) activating the PD-L1/PD-1 pathway, an important therapeutic target. There is limited information regarding PD-L1 and PD-1 expression in thymic lesions. Sections from non-neoplastic thymi (n=20), thymomas WHO types A, AB, B1, B2 and B3 (n=38) and thymic squamous cell carcinoma (n=8) were stained for PD-L1 (clone SP142 Spring BioScience), PD-1 (MRQ22 Cell Marque), CD4 (clone SPO32 Cell Marque) and CD8 (JCB117 Ventana)...
October 13, 2016: Human Pathology
Anneliese Velez-Perez, Xiaohong I Wang, Min Li, Songlin Zhang
Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papilloma virus (HPV) infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluated Sirtuin1 (SIRT1) expression in non-neoplastic cervix, CINs and SCC as a potential biomarker to predict disease progression. A total of 101 cases were selected including 29 CIN 1, 32 CIN 2, 16 CIN 3, 2 microinvasive SCC and 22 invasive SCC...
October 6, 2016: Human Pathology
S Piciucchi, S Tomassetti, T V Colby, V Poletti
No abstract text is available yet for this article.
October 5, 2016: Human Pathology
Simona Righi, Stefano Pileri, Claudio Agostinelli, Francesco Bacci, Sebastiano Spagnolo, Elena Sabattini
Mantle cell lymphoma (MCL) usually harbor the t(11;14)(q13;q32) with overexpression of CCND1 mRNA and transcription of the cyclin D1 nuclear protein. Regardless CCND1 status, most MCLs also express the SOX11 nuclear protein, which is thus helpful in the diagnosis of the rare CCND1 negative MCLs. Recently, SOX11 has been reported to be often negative in MCLs clinically resembling marginal zone lymphoma and recently defined as "leukemic non-nodal" MCL in the incoming revision of the WHO Classification of lymphoid tumors, for which the bone marrow biopsy is commonly the first diagnostic approach...
October 5, 2016: Human Pathology
Melanie C Bois, Xiaowen Hu, Jay H Ryu, Eunhee S Yi
No abstract text is available yet for this article.
October 5, 2016: Human Pathology
Liz Edmund, Katherine L Rotker, Nelli S Lakis, Joseph M Brito, Marcos Lepe, Kara A Lombardo, Joseph F Renzulli, Andres Matoso
Prostate cancer management changed in recent times given the recommendation against PSA-screening, adherence to active surveillance, and "cytoreductive" surgery. We hypothesized that radical prostatectomy (RP) findings changed as well. All consecutive RPs (n=1348), and first time prostate needle biopsies (n=1719) in a period of 9 years were reviewed. The cohort was separated into 3 groups: 1) from 5/2006 to 4/2009; 2) from 5/2009 to 4/2012; 3) from 5/2012 to 4/2015.The number of RPs decreased 15% from 551 in group-1 to 476 in group-2 and decreased further 35% to 311 in group-3...
October 5, 2016: Human Pathology
Melanie C Bois, Hiroshi Sekiguchi, Jay H Ryu, Eunhee S Yi
Pulmonary nodular lymphoid hyperplasia (PNLH) may show heavy lymphoplasmacytic infiltrates with increased Immunoglobulin G4 (IgG4)-positive plasma cells as in IgG4-related disease (IgG4-RD). However, it is unclear whether PNLH could be a manifestation of IgG4-RD. A recent study reported the presence of Epstein-Barr virus (EBV) in IgG4-related lymphadenopathy. We postulated that a subset of PNLH might represent IgG4-related lung disease (IgG4-RLD) with EBV-positive lymphocytes as has been reported in IgG4-related lymphadenopathy...
October 5, 2016: Human Pathology
Bingjian Lu, Haiyan Shi, Xiaofei Zhang
Uterine myxoid leiomyosarcoma (MLMS) is a rare tumor that requires modified diagnostic criteria compared with conventional leiomyosarcoma. We analyzed the clinicopathological and immunohistochemical features of 10 MLMS cases from a single institution. 9/10 MLMS showed an invasive border and 2/10 had vascular invasion. Seven cases exhibited low-grade nuclear features, low mitotic counts (median: 2/10HPFs) and no tumor cell necrosis. They were all at FIGO stage I. Two recurred at the vaginal vault at 38 and 61 months, respectively...
October 4, 2016: Human Pathology
Lori D Racsa, Marlene DeLeon-Carnes, Matthew Hiskey, Jeannette Guarner
16S sequencing on formalin-fixed paraffin-embedded (FFPE) material has been used to identify bacteria when culture-based phenotyping techniques have not worked. The objective of this study was to determine how frequently 16S sequencing used in FFPE material was helpful to clinicians in the diagnosis and treatment of infectious diseases. Requests for testing occurred upon consultation between an infectious disease pathologist and a surgical pathologist or an infectious disease physician. A selected paraffin block from each case was referred for 16S sequencing...
October 4, 2016: Human Pathology
Margot M Koeneman, Freyja Hm van Lint, Sander Mj van Kuijk, Luc Jm Smits, Loes Fs Kooreman, Roy Fpm Kruitwagen, Arnold J Kruse
This study aims to develop a prediction model for spontaneous regression of cervical intraepithelial neoplasia grade 2 (CIN 2) lesions based on simple clinical and pathological parameters. The study was conducted at Maastricht University Medical Center, the Netherlands. The prediction model was developed in a retrospective cohort of 129 women with a histological diagnosis of CIN 2 who were managed by watchful waiting for 6-24months. Five potential predictors for spontaneous regression were selected based on the literature and expert opinion and were analyzed in a multivariable logistic regression model, followed by backward stepwise deletion based on the Wald test...
September 30, 2016: Human Pathology
Sanghui Park, Soomin Ahn, Mineui Hong, Young Hyeh Ko
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a rare extranodal marginal zone B-cell lymphoma that is often associated with plasmacytic differentiation. However, the clinicopathologic characteristics of gastric MALT lymphoma with increased plasmacytic differentiation have not yet been studied. To assess the clinicopathologic implications of gastric MALT lymphoma with increased plasmacytic differentiation, thirty-six cases with increased plasmacytic differentiation and a control group of 16 cases with minimal plasmacytic differentiation were retrospectively collected from 65 primary gastric MALT lymphomas (2010~2012)...
September 30, 2016: Human Pathology
Misa Yoshida, Satoshi Hamanoue, Masafumi Seki, Mio Tanaka, Kenichi Yoshida, Hiroaki Goto, Seishi Ogawa, Junko Takita, Yukichi Tanaka
Anaplastic sarcoma of the kidney (ASK) is a tumor found in the pediatric age group and shows many histopathological similarities to pleuropulmonary blastoma (PPB). We present a 12-year-old girl diagnosed with ASK and, three years later, with thyroid follicular carcinoma (TFC) with DICER1 abnormalities. Germline insertion/deletion (p.G1809_S1814delinsA) and independent somatic mutations (p.E1705K in ASK, p.E1813D in TFC) were identified. All of these abnormalities are in the catalytic domain of RNase IIIb. Single-nucleotide polymorphism genotyping microarray revealed independent copy number alterations (trisomy 8, monosomy 10, loss of 17p and partial gain of 17q in ASK; trisomy 5 and partial loss of Xq in TFC)...
September 30, 2016: Human Pathology
Gordana Juric-Sekhar, Melissa P Upton, Paul E Swanson, Maria A Westerhoff
Cytomegalovirus (CMV) causes clinically significant gastrointestinal (GI) injury. CMV inclusions can be identified on routine hematoxylin and eosin (H&E) stain, but immunohistochemistry (IHC) is also available for identifying CMV in tissue. The advent of accountable care organization (ACO) models of care bring into question whether it is cost-effective for immunohistochemistry to be performed upfront at the request of clinicians and whether the quality of viral detection is compromised when the diagnosis of CMV is predicated on histologic review...
September 22, 2016: Human Pathology
Deniz Tuncel, Juan Carlos Roa, Juan Carlos Araya, Enrique Bellolio, Miguel Villaseca, Oscar Tapia, Kee-Taek Jang, Brian Quigley, Burcu Saka, Olca Basturk, Juan Sarmiento, Hector F Losada, Samip Patel, Michelle D Reid, Bahar Memis, Volkan Adsay
Signet-ring cell carcinoma is an extremely rare type of gallbladder carcinoma. In the gastrointestinal system, carcinomas with single-cell or cord-like infiltration, previously called "diffuse-infiltrative" type or "signet-ring cell", are now designated as "poorly cohesive cell" (PCC) type (regardless of with/without signet-ring cells) in the WHO-2010 classification. 628 primary invasive gallbladder carcinomas were reviewed for the PCC pattern. 24 cases in which classical poorly cohesive cell pattern constituted >50% of the tumor were included in the study...
September 22, 2016: Human Pathology
Jun-Ichiro Ikeda, Masaharu Kohara, Yoko Tsuruta, Satoshi Nojima, Shinichiro Tahara, Kenji Ohshima, Masako Kurashige, Naoki Wada, Eiichi Morii
Marginal zone lymphoma (MZL) is a low-grade B-cell lymphoma derived from marginal-zone B cells. Because of a lack of specific immunohistochemical markers, MZL is mainly diagnosed based on the cytological appearance and growth pattern of the tumor. Marginal-zone B cells were recently shown to selectively express immunoglobulin superfamily receptor translocation-associated 1 (IRTA1), but the antibody used in that study is not commercially available. We therefore investigated the IRTA1 expression in non-neoplastic lymphoid tissues and 261 malignant lymphomas, examining the ability of a commercially available antibody to accurately diagnose MZL...
September 22, 2016: Human Pathology
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