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Human Pathology

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https://www.readbyqxmd.com/read/28899741/small-bowel-stenosis-a-manifestation-of-chronic-graft-versus-host-disease-in-children
#1
Mickael Tordjman, Marie Ouachee, Arnaud Bonnard, Bogdana Tilea, Karima Yakouben, Jerome Viala, Michel Peuchmaur, Dominique Berrebi
Digestive graft versus host disease (GVHD) is a frequent complication after bone marrow transplantation (BMT), but small bowel obstruction is an extremely rare event. We present herein the first pediatric series of 4 cases of small bowel obstruction after BMT with detailed gross, histological data and their genetic status of the NOD2 gene. All patients had a history of severe acute GVHD treated by immunosuppressive agents and/or infliximab (in 3 cases). Acute or progressively worsening abdominal pain accompanied by small bowel occlusion occurred 5-16months after graft and CT-scan revealed multiple small intestinal stenosis...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28899740/histone-3-3-mutations-in-giant-cell-tumor-and-giant-cell-rich-sarcomas-of-bone
#2
Alberto Righi, Irene Mancini, Marco Gambarotti, Piero Picci, Gabriella Gamberi, Cristina Marraccini, Angelo Paolo Dei Tos, Lisa Simi, Pamela Pinzani, Alessandro Franchi
Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. While over 90% of GCTB presents histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study we examined a series of giant cell rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cell rich sarcomas...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28899739/epithelial-mesenchymal-transition-of-tumor-budding-in-colorectal-cancer-the-mystery-of-cd44-positive-stromal-cells
#3
LETTER
Simona Gurzu, Laura Banias, Zsolt Kovacs, Ioan Jung
No abstract text is available yet for this article.
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28899738/angiomyomatous-hamartoma-of-lymph-nodes-revisited-clinico-pathologic-study-of-21-cases-emphasizing-its-distinction-from-lymphangioleiomyomatosis-of-lymph-nodes
#4
Michelle Moh, Ankur Sangoi, Joseph T Rabban
Angiomyomatous hamartoma of lymph nodes (AMH-LN) is an uncommon benign proliferation of smooth muscle, blood vessels, collagenous stroma and adipocytes, most commonly affecting inguinal LN. A similar constellation of cell types constitutes various members of the perivascular epithelioid cell tumor (PEComa) family, including lymphangioleiomyomatosis (LAM) which can involve LN in women. Because some LN-LAM patients have tuberous sclerosis complex (TSC) and/or other PEComa family lesions, it is clinically relevant to distinguish LN-LAM from AMH-LN...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28899737/expression-of-yes-associated-protein-yap-and-its-clinical-significance-in-breast-cancer-tissues
#5
Lanqing Cao, Ping-Li Sun, Min Yao, Meng Jia, Hongwen Gao
The transcriptional co-activator YES-associated protein (YAP) has been reported to act as both an oncogene and tumor suppressor in breast cancers. In this study, we evaluated YAP expression immunohistochemically in 324 breast cancer tissues and correlated the expression with clinicopathological findings and patient survival data. Additionally, we reviewed the literature to clarify the role of YAP in breast cancer. We detected YAP, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth receptor-2 (HER2) expression and a Ki67 labeling index >20% in 53...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28899736/characterization-of-genome-wide-copy-number-aberrations-in-colonic-mixed-adenoneuroendocrine-carcinoma-and-neuroendocrine-carcinoma-reveals-recurrent-amplification-of-ptger4-and-myc-genes
#6
Namita Sinha, Daniel Gaston, Daniel Manders, Marissa Goudie, Makoto Matsuoka, Tao Xie, Weei-Yuarn Huang
Colonic Mixed adenoneuroendocrine Carcinoma (MANEC) is an aggressive neoplasm with worse prognosis compared to adenocarcinoma. To gain a better understanding of the molecular features of colonic MANEC, we characterized the genome-wide copy number aberrations (CNA) of 14 MANECs and 5 neuroendocrine carcinomas using the OncoScan FFPE assay. Compared to 269 colonic adenocarcinomas, 19 of 42 chromosomal arms of MANEC exhibited a similar frequency of major aberrant events as adenocarcinomas, and 13 chromosomal arms exhibited a higher frequency of copy number gains...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28893532/passport-to-pathology-transforming-the-medical-student-pathology-elective-from-a-passive-educational-experience-to-an-exciting-immersive-clinical-rotation
#7
EDITORIAL
Paras S Minhas, Imarhia E Enogieru, Richard N Mitchell, Douglas A Mata
No abstract text is available yet for this article.
September 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28890339/improving-undergraduate-pathology-teaching-medical-students-perspective-reply
#8
LETTER
YunXiang Chu, Richard N Mitchell, Douglas A Mata
No abstract text is available yet for this article.
September 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28890338/improving-undergraduate-pathology-teaching-medical-students-perspective
#9
LETTER
Nikhil Aggarwal, Subothini Sara Selvendran, Sudeep Kumar Biswas
No abstract text is available yet for this article.
September 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28889939/erratum-to-immunohistochemistry-staining-for-mismatch-repair-proteins-the-endoscopic-biopsy-material-provides-useful-and-coherent-results-hum-pathol-2015-46-1705-1711
#10
Alex Vilkin, Ya'ara Leibovici-Weissman, Marisa Halpern, Sara Morgenstern, Eli Brazovski, Rachel Gingold-Belfer, Nir Wasserberg, Baruch Brenner, Yaron Niv, Orly Sneh-Arbib, Zohar Levi
No abstract text is available yet for this article.
September 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882702/tumoral-foxp3-expression-is-associated-with-favorable-clinicopathological-variables-and-good-prognosis-in-gastric-adenocarcinoma-the-tumor-suppressor-function-of-tumoral-foxp3-is-related-with-the-p21-expression-in-gastric-adenocarcinoma
#11
Kyu Yeoun Won, Gou Young Kim, Hyung Kyung Kim, Sung Il Choi, Sang Hyun Kim, Go Eun Bae, Jun Uk Lim, Sung-Jig Lim
The function and its contribution of tumoral FOXP3 in gastric cancer development remains poorly understood. Thus, we studied the expression of tumoral FOXP3 and its relationship with the well-known tumor suppressor proteins P21 and P53 in gastric adenocarcinoma. The tissue microarray (TMA) was constructed from 182 cases of gastric adenocarcinoma. The immunohistochemistry was performed on 4μm tissue sections from each TMA block. We found that positive tumoral FOXP3 expression was significantly correlated with a lower T category, a lower N category, a lower recurrence rate, and less lymphatic invasion...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882701/diagnostic-value-of-histone-3-mutations-in-osteoclast-rich-bone-tumors
#12
Erik Nohr, Lik Hang Lee, Justin M Cates, Marco Perizzolo, Doha Itani
Differentiating osteoclast-rich lesions of bone (giant cell tumor of bone [GCTB], chondroblastoma [CBA], and aneurysmal bone cyst [ABC]) can be challenging, especially in small biopsies or fine needle aspirations. Mutations affecting codons 34 and 36 of either H3 Histone Family Member 3A (H3F3A) and/or 3B (H3F3B) are characteristically seen in GCTB and CBAs. We devised a simple assay to identify these mutations and evaluated its applicability for routine clinical diagnosis. 124 tissue specimens from 108 patients (43 GCTBs, 38 CBAs and 27 ABCs) were collected from the archives of the Calgary Laboratory Services/University of Calgary and Vanderbilt University Medical Center...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882700/net1-a-therapeutic-potential-target-for-cancer
#13
LETTER
Chen Chen, Qiu Ji
No abstract text is available yet for this article.
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882699/neutrophil-infiltration-is-a-favorable-prognostic-factor-in-early-stages-of-colon-cancer
#14
Maria L Wikberg, Agnes Ling, Xingru Li, Åke Öberg, Sofia Edin, Richard Palmqvist
The tumor immune response has been proven critical to prognosis in colorectal cancer (CRC), but studies on the prognostic role of neutrophil infiltration have shown contradictory results. The aim of this study was to elucidate the prognostic role of infiltrating neutrophils at different intratumoral subsites and in different molecular subgroups of CRC. The relations between neutrophil infiltration and infiltration of other immune cells (T-cell and macrophage subsets) were also addressed. Expression of the neutrophil marker CD66b was assessed by immunohistochemistry in 448 archival human tumor tissue samples from patients surgically resected for CRC...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882698/prognostic-value-of-microrna-9-and-microrna-155-expression-in-triple-negative-breast-cancer
#15
Min Hye Jang, Hyun Jeong Kim, Jae Moon Gwak, Yul Ri Chung, So Yeon Park
MicroRNAs (miRNAs) are involved in regulation of epithelial-mesenchymal transition (EMT) during breast cancer progression. The purpose of this study was to analyze the clinicopathologic significance of expression of EMT-related miRNAs, miR-9 and miR-155, in triple-negative breast cancers (TNBCs). We analyzed relative expression levels of miR-9 and miR-155 in 190 surgically resected TNBC specimens using quantitative real-time polymerase chain reaction. Then we analyzed the relationship between these miRNA expression levels and EMT marker expression (vimentin, smooth muscle actin (SMA), osteonectin, N-cadherin, E-cadherin, CD146, and ZEB1) assessed by immunohistochemistry...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882697/clinicopathologic-and-gene-expression-analysis-of-initial-biopsies-from-patients-with-eosinophilic-esophagitis-refractory-to-therapy
#16
Ayesha S Siddique, David C Corney, Shamlal Mangray, Kara A Lombardo, Sonja Chen, Alexander S Marwaha, Murray B Resnick, Michael Herzlinger, Andres Matoso
Some patients with eosinophilic esophagitis (EoE) do not respond to therapy. The clinicopathologic characteristics, and gene expression profile at time of presentation could help predict response to therapy. Refractory EoE was defined as persistence of symptoms and biopsies with histologic features of EoE after 6months of therapy with proton pump inhibitors and topical corticosteroids. Initial biopsies from refractory EoE patients (n=21), responder to therapy (n=8), patients who relapsed (n=6), and reflux controls (n=24) were studied...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882696/histone-deacetylases-inhibition-a-potential-diagnostic-and-therapeutic-target-for-cancers
#17
LETTER
Dexi Zhou, Kui Yang, Yuanyuan Wu, Jiajie Luan
No abstract text is available yet for this article.
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28873357/histone-deacetylases-inhibition-a-potential-diagnostic-and-therapeutic-target-for-cancers-reply
#18
LETTER
Daniel Neureiter, Tobias Kiesslich
No abstract text is available yet for this article.
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28873356/follicular-lymphoma-with-hyaline-vascular-castleman-like-features-analysis-of-6-cases-and-review-of-the-literature
#19
Sergio Pina-Oviedo, Roberto N Miranda, Pei Lin, John T Manning, L Jeffrey Medeiros
Follicular lymphoma (FL) with features reminiscent of hyaline-vascular Castleman disease (CD) is an unusual morphologic variant that may create diagnostic difficulties. To our knowledge, only 5 cases of this variant have been reported. We describe the clinicopathologic features of 6 cases including 2 men and 4 women with a median age of 63years (range, 41-77). Morphologically, all lymph node biopsy specimens showed at least a focal area of conventional FL; 4 cases showed neoplastic follicles with hyalinized blood vessels penetrating into germinal centers (lollipop-like lesions); 4 cases had interfollicular areas with increased vascular stroma, 2 cases showed small neoplastic follicles with prominent, onion skin-like mantle zones, and 1 case showed two or more germinal centers within follicles (twinning)...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28873355/pulmonary-interstitial-glycogenosis-associated-with-a-spectrum-of-neonatal-pulmonary-disorders
#20
Ernest Cutz, Rose Chami, Sharon Dell, Jacob Langer, David Manson
Primary or isolated pulmonary interstitial glycogenosis (PIG) is a rare disease presenting as tachypnea and hypoxemia during the perinatal period. A diffuse interstitial infiltrate with focal hyperinflation is visible on chest imaging. The biopsy findings include diffuse expansion of the interstitium by spindle-shaped cells with pale cytoplasm that, on electron microscopy (EM), are poorly differentiated mesenchymal cells containing abundant monoparticulate glycogen. This glycogenosis appears to be a transient abnormality, usually with a favorable prognosis...
September 2, 2017: Human Pathology
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