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Human Pathology

Leonardo S Lino-Silva, Rosa A Salcedo-Hernández, Alejandro España-Ferrufino, Erika B Ruiz-García, Miguel Ruiz-Campos, Alberto M León-Takahashi, Abelardo Meneses-García
Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated in the head and neck and prostate carcinomas, but its significance in rectal cancer is controversial. Most studies have focused on evaluating mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis after rectal cancer resection. We evaluated the prognostic value of ePNI compared with mPNI and with non-PNI, in rectal resections after preoperative chemoradiotherapy in 148 patients with pT3 and pT4 rectal carcinomas...
May 16, 2017: Human Pathology
Yuting Zhang, Pei Xia, Wenhui Zhang, Min Yan, Xiujuan Xiong, Weiwei Yu, Enlin Song
Net1, a guanine nucleotide exchange factor, is implicated in cancer cell invasion through activation of RhoA. However, there is still no report on the association between Net1 and cancer angiogenesis. The current study was designed to explore the roles of Net1 in the angiogenesis of cervical squamous cell carcinoma (CSCC) and further observe the effects of Net1 siRNA on the tumor growth. Net1 was overexpressed in CSCC samples (n=80), correlated to the cancer microvessel density (MVD, r=0.223, P=.026) and related to aggressive clinical behaviors, including depth of cervical wall invasion (P=...
May 13, 2017: Human Pathology
Darcy A Kerr, Satya Vara Prasad Busarla, Devon C Gimbel, Aliyah R Sohani, Rosalynn M Nazarian
Kaposi sarcoma (KS) is a locally progressive, intermediate-grade vascular neoplasm with no known cure, high recurrence rates and potential for wide dissemination. Low efficacy and high toxicity limit current therapeutic options for advanced disease. Activation of mammalian target of rapamycin (mTOR), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and c-kit signaling pathways has been implicated in KS pathogenesis and may suggest a role for targeted inhibitors. KS cases were retrospectively retrieved (n=274), most (90%) associated with human immunodeficiency virus (HIV)...
May 12, 2017: Human Pathology
Hiroyuki Hayashi, Steven Mann, Chia-Sui Kao, David Grignon, Muhammad T Idrees
Upper urinary tract urothelial carcinoma exhibiting variant morphology, especially in higher-grade tumors, is a recognized phenomenon but has not been comparatively studied in biopsy versus resection material. We studied the morphologic patterns and clinicopathological features, and provide a comparison between biopsy and resection specimens. Consultation cases were evaluated separately to investigate for possible consultation bias. A total of 383 in-house cases from 352 patients including 314 resection specimens and 69 biopsies from 2001-2014 were reviewed from a single institution...
May 12, 2017: Human Pathology
Ilaria Posenato, Anna Caliò, Diego Segala, Salvatore Sgroi, Andrea Polara, Matteo Brunelli, Guido Martignoni
Primary seminal vesicle carcinoma is a rare entity whose diagnosis can be achieved ruling out the main carcinomas that commonly invade the seminal vesicles. Although a panel of immunohistochemical markers (CA125, CK7, CK20, PSA and PSAP) has been proposed as unique for primary seminal vesicle carcinoma, a reliable positive marker is lacking. In this article, we report a case of primary seminal vesicle carcinoma in a 57-years-old man. The tumor was localized to the left seminal vesicle and histologically characterized by papillae lined by broad eosinophilic cells with pleomorphic nuclei...
May 12, 2017: Human Pathology
Arpan V Prabhu, Christopher Kim, Tudor Crihalmeanu, David R Hansberry, Nitin Agarwal, Marie C DeFrances, Humberto E Trejo Bittar
Information for patients regarding their clinical conditions and treatment options is widely available online. The American Medical Association and National Institutes of Health recommend that online patient-oriented materials be written at no higher than a 7th grade reading level to ensure full comprehension by the average American. This study sought to determine whether online patient-oriented materials explaining common pathology procedures are written at appropriate reading levels. Ten pathology procedures that patients would likely research were queried into Google search, and plain text from the first 10 websites containing patient education materials for each procedure were analyzed using 10 validated readability scales...
May 10, 2017: Human Pathology
Shira Ronen, Daniel W Abbott, Oleksandr Kravtsov, Amrou Abdelkader, Yayun Xu, Anjishnu Banerjee, Kenneth A Iczkowski
The presence and extent of cribriform pattern of prostate cancer portend recurrence and cancer death. Therelative expressions within this morphology of the prognostically adverse loss of PTEN, and the downstream inactivation of cell cycle inhibitor p27/Kip1 had been uncertain. In this study, we examined 52 cases of cribriform cancer by immunohistochemistry (IHC) for PTEN, p27, and CD44 variant (v)7/8, and a subset of 17 casesby chromogenic in situ hybridization (ISH) using probe for PTEN or CDKN1B (gene for p27)...
May 10, 2017: Human Pathology
Kentaro Inamura, Maki Kobayashi, Hiroko Nagano, Yoshiya Sugiura, Masahiro Ogawa, Hitoshi Masuda, Junji Yonese, Yuichi Ishikawa
Here, we report an inflammatory myofibroblastic tumor (IMT) of the urinary bladder with a novel HNRNPA1-ALK fusion. To the best of our knowledge, this is the first case of a tumor with HNRNPA1-ALK fusion. A 42-year-old Japanese man underwent total cystectomy because of an invasive urinary bladder tumor. Grossly, the tumor had invaded the peribladder fat tissue. Histologically, it comprised spindle neoplastic cells with intermingled inflammatory cells. Immunohistochemically, it was positive for ALK, SMA, desmin, cytokeratin, and vimentin, consistent with the immunohistochemical characteristics of IMTs...
May 10, 2017: Human Pathology
Piti Techavichit, Darintr Sosothikul, Thiamjit Chaichana, Chinachote Teerapakpinyo, Paul Scott Thorner, Shanop Shuangshoti
Juvenile xanthogranuloma (JXG) is a cutaneous form of non-Langerhans cell histiocytosis (LCH), primarily affecting children. The lesion is presumed to originate from either macrophages or dermal dendritic cells. JXG can rarely present as an isolated intracranial lesion and, in contrast to the dismal outcome of patients with systemic disease, cranial JXG has been shown to carry a more favorable prognosis. Here, we report for the first time 3 pediatric cases of JXG with a BRAF V600E mutation, 2 with intracranial lesions and one with cranial lesions...
May 10, 2017: Human Pathology
Akiko Miyagi Maeshima, Hirokazu Taniguchi, Tomotaka Suzuki, Sayako Yuda, Kosuke Toyoda, Nobuhiko Yamauchi, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Yukio Kobayashi, Yutaka Saito, Kensei Tobinai
We compared the incidence, esophagogastroduodenoscopy (EGD) findings, and histopathologic characteristics of gastric and duodenal follicular lymphomas (FL). Of 626 FL cases, primary gastric FL and secondary gastric involvement of FL were observed in 1% and 5% of the cases, respectively, which were lower incidences than duodenal FL (10% and 9%, respectively). Gastric FL usually appeared as submucosal tumors (primary, 71%: secondary, 79%), whereas duodenal FL as granular lesions (primary, 92%: secondary, 87%)...
May 10, 2017: Human Pathology
Guang Lei, Haiyan Yang, Ting Hong, Chunhua Zhou, Jigang Li, Wenbin Liu, Jun Hu, Liang Zeng, Gong Chen, Qiong Chen, Yongchang Zhang, Nong Yang
Prognosis of pT3N0M0 gastric cancer (GC) varies greatly, though the major factor conferring poor prognosis is unclear. Subserosal elastic lamina invasion (ELI+) is closely associated with poor outcomes in pT3 colorectal cancer, but related research on GC is unavailable. This study aimed to identify the influence of ELI+ on the prognosis of patients with pT3N0M0 GC and its relationship with serosal invasion using elastic staining. We retrospectively reviewed 94 and 28 patients with pT3N0M0 and pT4aN0M0 GC who underwent gastrectomy between 1994 and 2005...
May 10, 2017: Human Pathology
Zena Salih, Angela Lamarca, Daisuke Nonaka, Richard A Hubner, Nicola de Liguori-Carino, Mairéad G McNamara, Paul Fulford, Annamaria Minicozzi, Sarah O'Dwyer, Bipasha Chakrabarty, Juan W Valle
No abstract text is available yet for this article.
May 9, 2017: Human Pathology
Karan Saluja, Randall T Butler, Kristen B Pytynia, Bihong Zhao, Ron J Karni, Randal S Weber, Adel K El-Naggar
We report the development of mucoepidermoid carcinomas (MEC) of the parotid gland in two adult patients after a relatively short duration of radioactive iodine (RAI) treatment for papillary thyroid carcinoma (PTC). Both instances, together with those previously reported, underscore the selective nature of the MEC phenotype development in patients with PTC as a consequence of RAI treatment. Efforts to alleviate salivary pathophysiologic damage by RAI in these patients are warranted.
May 9, 2017: Human Pathology
Anand C Annan, Keith A Stevens, Adeboye O Osunkoya
Although tumors involving the bladder and ureter have been well described, there are only few studies in the pathology literature specifically analyzing tumors involving the ureteral orifice (UO). A search was performed for biopsy and resection specimens (transurethral resection, radical cystectomy/cystoprostatectomy, nephroureterectomy and bladder cuff resection) of urothelial carcinoma (UCa) involving the UO. Ninety three cases were identified. Sixty two (67%) patients were male. Mean patient age was 71years (range: 43-91years)...
April 29, 2017: Human Pathology
Michelle van der Linden, Peter Bult, Iris D Nagtegaal, Leon F A G Massuger, Joanne A de Hullu, Johan Bulten
Vulvar Paget disease is a rare skin disorder, considered an in situ adenocarcinoma. It is characterized by intraepithelial Paget cells, of which the origin is unclear. About 75% of cases have a cutaneous origin, the other 25% originate from an intestinal or urological malignancy. We report the first case of retrograde Pagetoid spread from a rectal adenocarcinoma to the vulva and cervix. A 66-year-old woman presented with postmenopausal bleeding and a history of Crohn's disease. Gynaecological work-up revealed vulvar and endocervical lesions consisting of Paget cells and adenocarcinoma, respectively...
April 28, 2017: Human Pathology
Claudio Agostinelli, Elena Sabattini, Stefano A Pileri, Marco Fabbri
No abstract text is available yet for this article.
April 28, 2017: Human Pathology
Xiao-Fang Zhang, Min Dong, Yu-Hang Pan, Jian-Ning Chen, Xiang-Qi Huang, Yi Jin, Chun-Kui Shao
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and lacks of effective treatment, characterized by dense desmoplastic stroma rich in cancer-associated fibroblasts (CAFs), which have been indicated to facilitate tumor progression in several types of human cancer. However, the clinical relevance of CAFs in ICC has not been fully characterized. Here, we evaluated the histological phenotype of CAFs and immunohistochemical expressions of α-SMA, FSP-1, and PDGFRβ in 71 ICC cases, and found that immature CAF phenotype was significantly associated with lymph node metastasis (P=...
April 27, 2017: Human Pathology
Kamaljeet Singh, Yihong Wang, Shivali Marketkar, Elizabeth T Kalife, Margaret M Steinhoff
There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurrent biopsies with invasive breast tumors. Consecutive ipsilateral concurrent biopsies with invasive breast tumors were identified retrospectively. Biomarker results, histologic grade and histologic subtype among the tumors in concurrent samples were compared...
April 27, 2017: Human Pathology
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