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Human Pathology

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https://www.readbyqxmd.com/read/29981770/diagnostic-criterion-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-absence-of-papillae
#1
LETTER
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Human Pathology
https://www.readbyqxmd.com/read/29981769/telocytes-as-possible-precursors-of-pdgfra-mutant-gastrointestinal-mesenchymal-tumors
#2
LETTER
Maria C Giustiniani, Paola Lanza, Riccardo Ricci
No abstract text is available yet for this article.
July 5, 2018: Human Pathology
https://www.readbyqxmd.com/read/29981768/telocytes-as-possible-precursors-of-pdgfra-mutant-gastrointestinal-mesenchymal-tumors-reply
#3
LETTER
Paul Manley, Jagdeep S Walia, Richard Kirsch, Robert Riddell
No abstract text is available yet for this article.
July 5, 2018: Human Pathology
https://www.readbyqxmd.com/read/29981308/co-expression-of-cdx2-and-ck20-in-hepatocellular-carcinoma-an-exceedingly-rare-co-incidence-with-potential-diagnostic-pitfall-reply
#4
LETTER
Vishal S Chandan, Sejal S Shah, Michael S Torbenson, Tsung-Teh Wu
No abstract text is available yet for this article.
July 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29969607/benign-tdt-positive-cells-in-pediatric-and-adult-lymph-nodes-a-potential-diagnostic-pitfall
#5
Marco Pizzi, Stefano Brignola, Simona Righi, Claudio Agostinelli, Clara Bertuzzi, Marta Pillon, Gianpietro Semenzato, Massimo Rugge, Elena Sabattini
Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes. This study is aimed to: (i) characterize the presence/distribution of benign TdT-positive cells in pediatric and adult reactive lymph nodes; (ii) define the phenotype and nature of such elements. This retrospective study considered 141 reactive lymph nodes from pediatric and adult patients without history of neoplastic disease. TdT-positive cells were characterized by immunohistochemical and morphometric analyses and their presence was correlated with the clinical-pathological features...
June 30, 2018: Human Pathology
https://www.readbyqxmd.com/read/29969606/pd-l1-expression-in-tumor-cells-and-the-immunologic-milieu-of-bladder-carcinomas-a-pathologic-review-of-165-cases
#6
Jonathan J Davick, Henry F Frierson, Mark Smolkin, Alejandro A Gru
Programmed death ligand 1 (PD-L1) is a transmembrane protein that plays a major role in immune suppression. Its interaction with the receptor PD-1 results in downregulation of antitumoral immunity. Humanized monoclonal antibodies that interrupt the PD-L1/PD-1 interaction have shown therapeutic efficacy in patients with advanced urothelial cancer. However, immunohistochemical staining of PD-L1 in bladder tumors and its relationship to tumor histologic type, grade, and overall survival has been incompletely analyzed...
June 30, 2018: Human Pathology
https://www.readbyqxmd.com/read/29958927/the-role-of-next-generation-sequencing-in-the-differential-diagnosis-of-composite-neoplasms
#7
Andres M Acosta, Mohamed R H Al Rasheed, Michael R Pins, Kristina R Borgen, Dipti Panchal, Magdalena Rogozinska, Elizabeth L Wiley, Frederick G Behm, Gayatry Mohapatra
Composite neoplasms (CN) are rare and diagnostically challenging lesions that require differentiating between mixed clonal tumors with divergent phenotypes (MT), collision of two independent tumors adjacent to each other (CT) and tumor-to-tumor metastasis (TTM). To that end, pathologists have traditionally used Immunohistochemistry and limited molecular studies, such as Sanger sequencing. Herein we evaluate the potential application of NGS in the differential diagnosis of these rare neoplasms. Four CNs were included in the study...
June 26, 2018: Human Pathology
https://www.readbyqxmd.com/read/29958926/clinicopathologic-characterization-of-breast-carcinomas-in-patients-with-non-brca-germline-mutations-results-from-a-single-institution-s-high-risk-population
#8
Alice E Meiss, Martha Thomas, Susan C Modesitt, Kari L Ring, Kristen A Atkins, Anne M Mills
As multigene panel testing for hereditary cancer syndromes becomes commonplace, germline mutations in genes other than BRCA1/2 are increasingly identified in breast cancer patients. While histopathologic features of BRCA-mutated breast cancers have been well-characterized, less is known about non-BRCA-related hereditary cancers. We herein investigate the clinicopathologic characteristics of breast cancers in women with non-BRCA germline mutations. Out of 612 women who underwent germline testing, 16 (2.6%) of women with 18 cancers had mutations in non-BRCA genes: ATM, CHEK2, PALB2, TP53, BMPR1A, BRIP1, MUTYH, and RAD50...
June 26, 2018: Human Pathology
https://www.readbyqxmd.com/read/29958690/corrigendum-to-pericytic-mimicry-in-well-differentiated-liposarcoma-atypical-lipomatous-tumor-hum-pathol-2016-54-92-99
#9
Jia Shen, Swati Shrestha, P Nagesh Rao, Greg Asatrian, Michelle A Scott, Vi Nguyen, Paulina Giacomelli, Chia Soo, Kang Ting, Fritz C Eilber, Bruno Peault, Sarah M Dry, Aaron W James
No abstract text is available yet for this article.
June 26, 2018: Human Pathology
https://www.readbyqxmd.com/read/29953896/temporal-small-arterial-inflammation-is-common-in-patients-with-giant-cell-arteritis
#10
Chaohui Lisa Zhao, Yiang Hui, Ali Amin
Giant cell arteritis (GCA) primarily involves medium-to-large arteries. Small vessel inflammation is a recognized phenomenon occurring in association with GCA. However, its significance is poorly elucidated. Histologic sections and medical records of105 temporal artery specimens were retrospectively reviewed between 2008 and 2017 to examine associated clinical manifestations and laboratory data including ANA and p-ANCA titers. Immunohistochemical staining for CD4 and CD8 was performed in select cases to assess the nature of the inflammatory response...
June 25, 2018: Human Pathology
https://www.readbyqxmd.com/read/29953895/co-expression-of-cdx2-and-ck20-in-hepatocellular-carcinoma-an-exceedingly-rare-coincidence-with-potential-diagnostic-pitfall
#11
LETTER
Tony El Jabbour, Nicole Durie, Hwajeong Lee
No abstract text is available yet for this article.
June 25, 2018: Human Pathology
https://www.readbyqxmd.com/read/29953894/clinicopathological-and-prognostic-significance-of-shp2-and-hook1-expression-in-patients-with-thyroid-carcinoma
#12
Jun Cao, Yu-Qing Huang, Jiao-Sun, Xia-Bin Lan, Ming-Hua Ge
Some thyroid carcinomas (TCs) have a violent biological behavior and poor prognosis, and lacking of effective molecular markers is still the main obstacle for clinical stratified diagnosis and treatment of TC. The aim of the study was to discover the clinicopathological and prognostic implications of Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) and Hook microtubule tethering protein 1(Hook1) expression in TC. The expression of SHP2 and Hook1was detected by immunohistochemistry on tissue microarrays from 313 primary TC who underwent surgery during January 2006 and January 2010 in Zhejiang Cancer Hospital...
June 25, 2018: Human Pathology
https://www.readbyqxmd.com/read/29949742/microglandular-adenosis-of-the-breast-a-deceptive-and-still-misterious-benign-lesion
#13
Maria P Foschini, Vincenzo Eusebi
Microglandular adenosis of the breast (MA), a benign glandular proliferation, was originally described about 35years ago. The lesion, is constituted by small glands all of the same size. Glands are lined by one layer of cuboidal epithelial cells encircled by basal lamina without any evidence of interposed myoepithelial elements. Cells are positive for low weight keratins and S-100 protein and negative for ER, PR and HER 2. Since then, in the years, several malignant lesions all showing microglandular architecture have been regarded either as a precursor or an equivalent manifestation of MA...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29949741/genomic-structures-of-dysplastic-nodule-and-concurrent-hepatocellular-carcinoma
#14
Minho Lee, Kyung Kim, Shinn Young Kim, Seung-Hyun Jung, Jonghwan Yoon, Min Sung Kim, Hyeon-Chun Park, Eun Sun Jung, Yeun-Jun Chung, Sug Hyung Lee
Although high-grade dysplastic nodule (HGDN) is a preneoplastic lesion that precedes hepatocellular carcinoma (HCC), the genomic structures of HGDN in conjunction with HCC remain elusive. The objective of this study was to identify genomic alterations of HGDN and its difference from HCC that may drive HGDN progression to HCC. We analyzed 16 regions of paired HGDN and HCC from 6 patients using whole-exome sequencing to find somatic mutation and copy number alteration (CNA) profiles of HGDN and HCC. The number of mutations, driver mutations, and CNAs of HGDNs were not significantly different from those of HCCs...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29949740/fluorescence-in-situ-hybridization-for-the-diagnosis-of-nphp1-deletion-related-nephronophthisis-on-renal-biopsy
#15
Christopher P Larsen, Stephen M Bonsib, Marjorie L Beggs, Jon D Wilson
Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end stage renal disease in children and young adults. Approximately 60% of patients with a known genetic etiology of nephronophthisis are due to homozygous deletion of the NPHP1 gene. We identified a total of 45 renal biopsies from young patients with chronic kidney disease of undetermined etiology and analyzed them for the possibility of nephronophthisis due to NPHP1 deletion using interphase fluorescence in situ hybridization and/or polymerase chain reaction...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29949739/mixed-phenotype-large-granular-lymphocytic-leukemia-lgll-a-rare-subtype-in-the-lgll-spectrum
#16
Jadee L Neff, Aruna Rangan, Dragan Jevremovic, Phuong L Nguyen, April Chiu, Ronald S Go, Dong Chen, William G Morice, Min Shi
Large granular lymphocytic leukemia (LGLL) is a chronic proliferation of cytotoxic lymphocytes in which over 70% of patients develop cytopenia(s) requiring therapy. LGLL includes T-cell LGLL (T-LGLL) and chronic lymphoproliferative disorder of NK-cells (CLPD-NK). The neoplastic cells in LGLL usually exhibit a single immunophenotype in a patient, with CD8-positive/αβ T-cell type being the most common, followed by NK-cell, γδ T-cell, and CD4-positive/αβ T-cell types. We investigated a total of 220 LGLL cases and identified 12 mixed-phenotype LGLLs (5%): 7 cases with coexistent αβ T-cell and NK-cell clones and 5 with coexistent αβ and γδ T-cell clones...
June 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29944973/ovarian-carcinomas-at-least-five-different-diseases-with-distinct-histological-features-and-molecular-genetics
#17
Jaime Prat, Emanuela D'Angelo, Iñigo Espinosa
Based on histopathology and molecular genetics, ovarian carcinomas are divided into five main types: high-grade serous (70%), endometrioid (10%), clear cell (10%), mucinous (3%), and low-grade serous (<5%) carcinomas. These tumors, which account for over 95% of cases, represent distinct diseases with different prognosis and treatments. TP53 mutations are identified in almost all (96%) high-grade serous carcinomas (HGSCs). Early p53 loss followed by BRCA loss leads to deficiency in homologous recombination (DHR) repair, which in turn triggers chromosomal instability and widespread somatic copy number changes...
June 23, 2018: Human Pathology
https://www.readbyqxmd.com/read/29944972/med12-is-frequently-mutated-in-ovarian-and-other-adnexal-leiomyomas
#18
Zhuo Li, Daichi Maeda, Yukitsugu Kudo-Asabe, Daisuke Tamura, Hiroshi Nanjo, Akimasa Hayashi, Masako Ikemura, Masashi Fukayama, Akiteru Goto
In the female genital tract, extra-uterine leiomyomas such as those that arise in the ovary and paraovarian/paratubal regions are rare. Currently, little is known about the background genetic changes in such adnexal leiomyomas. Recent studies have found that the MED12 mutation is common in uterine leiomyomas, which suggests that such mutations may play an oncogenic role in smooth muscle neoplasms in females. Herein, we examined a series of ovarian and other adnexal leiomyomas in terms of MED12 mutational status to investigate possible MED12 involvement in the pathogenesis of extra-uterine smooth muscle tumors...
June 23, 2018: Human Pathology
https://www.readbyqxmd.com/read/29944971/giant-cell-tumor-of-bone-updated-molecular-pathogenesis-and-tumor-biology
#19
Byeong-Joo Noh, Yong-Koo Park
GCTB-related clonal aberrations occur in a background of epigenetic histone modifications (especially, the G34 W mutation of H3F3A gene) that induce cytogenetic abnormalities. Clonal aberrations are closely linked to the aggressiveness of GCTB. The "neoplastic" mononuclear stromal cells in GCTB express fundamental RANKLs and various chemokines and cytokines associated with monocyte recruitment and "reactive" multinucleated giant cells (osteoclastogenesis). The reciprocal and orchestrated actions between mononuclear stromal cells and multinucleated giant cells helps in the understanding of the molecular pathogenesis and tumor biology of GCTB...
June 23, 2018: Human Pathology
https://www.readbyqxmd.com/read/29944970/nf2-and-atrx-gene-copy-number-losses-on-a-case-of-ovarian-ependymoma
#20
Liurka V Lopez, Siddharth Bhattacharyya, Eric D Carlsen, David Bartlett, Uma N M Rao
Ovarian ependymomas are rare glial neoplasms that typically occur in females on their 3rd to 4th decade of life. They are histologically similar to ependymomas of the central nervous system (CNS) but may have a broader immunophenotype. We describe a 27year old female who presented to the emergency room with a 3week history of cough and shortness of breath. Further workup disclosed a left pelvic mass and extensive intra-abdominal metastases. Pathology revealed sheets of monomorphic cells within a fibrillary stroma, papillary projections, true ependymal rosettes, and pseudorosettes consistent with an ependymoma of ovarian origin...
June 23, 2018: Human Pathology
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