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Human Pathology

Lea F Surrey, Pierre Russo, Jack Rychik, David J Goldberg, Kathryn Dodds, Michael L O'Byrne, Andrew C Glatz, Elizabeth B Rand, Henry C Lin
No abstract text is available yet for this article.
June 8, 2017: Human Pathology
Camilo Molina-Romero, Claudia Rangel-Escareño, Alette Ortega-Gómez, Gerardo J Alanis-Funes, Alejandro Aviles-Salas, Federico Avila-Moreno, Gabriela E Mercado, Andres F Cardona, Alfredo Hidalgo-Miranda, Oscar Arrieta
The current lung cancer classification from the Association for the Study of Lung Cancer (IASLC) / the American Thoracic Society (ATS)/ the European Respiratory Society (ERS) has considerably changed the pathologic diagnosis of lung invasive adenocarcinoma, identifying disease subtypes with substantial implications for medical practice, such as clinical, radiological, molecular and prognostic differences. We analyzed the differences in the genetic expression of adenocarcinoma subtypes according to the new classification...
June 8, 2017: Human Pathology
Jian-Zhong He, Zhi-Yong Wu, Shao-Hong Wang, Xia Ji, Cui-Xia Yang, Xiu-E Xu, Lian-Di Liao, Jian-Yi Wu, En-Min Li, Kai Zhang, Li-Yan Xu
Our previous studies have highlighted the importance of ezrin in esophageal squamous cell carcinoma (ESCC). Here our objective was to explore the clinical significance of ezrin-interacting proteins, which would provide a theoretical basis for understanding the function of ezrin and potential therapeutic targets for ESCC. We employed affinity purification and mass spectrometry to identify PDIA3, CNPY2 and STMN1 as potential ezrin-interacting proteins. Confocal microscopy and co-immunoprecipitation analysis further confirmed the colocalization and interaction of ezrin with PDIA3, CNPY2 and STMN1...
June 8, 2017: Human Pathology
Po-Ming Chen, Pei-Yi Chu, Shiao-Lin Tung, Chun-Yu Liu, Yi-Fang Tsai, Yen-Shu Lin, Wan-Lun Wang, Yu-Ling Wang, Pei-Ju Lien, Ta-Chung Chao, Ling-Ming Tseng
Breast cancer subtypes can be stratified by immunohistochemical (IHC) expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2). The signaling pathways mediated by these receptors are the dominant drivers of cell proliferation and survival in the majority of human breast cancers. One of the most frequently overactivated pathways in breast cancer is the AKT signaling cascade. Protein phosphatase 2A (PP2A) acts as a switch to turn off signal transduction in the AKT pathway; however, it is frequently inactivated in many cancers by phosphorylation of Tyr-307 to form phosphoprotein phosphatase 2A (p-PP2A)...
June 8, 2017: Human Pathology
Beate Haugk, Yvonne Bury, Louise Coats, John O'Sullivan, Mark Hudson
No abstract text is available yet for this article.
June 8, 2017: Human Pathology
Guangyi Liu, Xudong Peng, Yongqian Cai, Anqi Cheng, Lang Zha, Ziwei Wang
We investigated the expression of dimethyladenosine transferase 1 homolog (DIMT1) in human gastric carcinoma (GC) tissues, pericarcinoma histologically normal tissues (PCHNTs), and normal gastric tissues and explored its clinical significance. Immunohistochemistry staining was used to detect the expression of DIMT1, and the findings were compared with clinicopathologic features of patients with GC. The result also was ascertained by Western blotting. The Kaplan-Meier method and log-rank test were employed to compare the overall survival rate and time in the DIMT1 low-level and high-level expression groups...
June 7, 2017: Human Pathology
Satoshi Kuwamoto, Michiko Matsushita, Kenichi Takeda, Natsumi Tanaka, Yukari Endo, Akira Yamasaki, Kenichi Kohashi, Yoshinao Oda, Yasushi Horie
SMARCA4-deficient thoracic sarcoma is a recently proposed new entity of soft tissue sarcomas with an undifferentiated round cell morphology that is diagnostically challenging. Here we report a case of this tumor where the diagnosis was established using limited samples and resources. A woman in her early 30s developed two intrathoracic masses. Biopsies for these lesions showed sheets of undifferentiated round/rhabdoid cells that retained SMARCB1 expression. Further analysis revealed a reduced SMARCA4 expression and a complete loss of SMARCA2 expression in tumor cells...
June 7, 2017: Human Pathology
Iñigo Espinosa, Neus Serrat, Gian Franco Zannoni, Ramón Rovira, Emanuela D'Angelo, Jaime Prat
In endometrioid endometrial carcinomas (EEC), MELF (microcystic, elongated and fragmented) myoinvasion is associated with easily overlooked lymph node metastases; however, the role of immunohistochemistry in their detection and their clinical significance have not been addressed. We identified MELF in 43 of 101 (43%) myoinvasive EECs. Nodes were removed in 49 (49%), 25 with MELF and 24 without MELF. Metastases were initially reported in 3 of the former (12%) and 2 of the latter (8%). All negative nodes were reviewed and cytokeratin immunohistochemistry was performed...
June 7, 2017: Human Pathology
Takashi Oide, Osamu Kadosono, Jun Matsushima, Di Wu, Hiroaki Nagashima, Hideto Saigusa, Atsuko Masunaga, Yukio Nakatani, Kenzo Hiroshima
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm originating from the nasopharyngeal surface epithelium. Histopathologically, TL-LGNPPA is characterized by cuboidal/columnar tumor cells forming papillary fronds and thyroid transcription factor-1 (TTF-1) expression resembling papillary thyroid carcinoma. To date, the recorded histological features of TL-LGNPPA have been almost uniform, and the range of histological variations in this tumor type has not been sufficiently understood...
June 7, 2017: Human Pathology
Ryan F Coates, Juli-Anne Gardiner, Yuan Gao, Valerie M Cortright, Jeannette M Mitchell, Takamaru Ashikaga, Joan Skelly, Michelle Yang
Inactivation of genes in the TGF-β/SMAD signaling pathway is a well-known step for the progression of colorectal cancers (CRC). Genetic mutations can occur in the precursors and the combined prevalence of SMAD4, SMAD2, and SMAD3 mutations was seen in up to 50% of CRCs. High levels of serum TGF-β1 were reported in patients with CRC and were associated with poor clinical outcome. PPM1A is an important inhibitory regulator in the TGF-β signaling pathway and contributes terminating the TGF-β/SMAD signaling activity...
June 7, 2017: Human Pathology
Julia Martinez Perez, Iker Lopez-Calderero, Carmen Saez, Marta Benavent, Maria L Limon, Reyes Gonzalez-Exposito, B Soldevilla, Maria C Riesco-Martinez, Javier Salamanca, Amancio Carnero, Rocio Garcia-Carbonero
Src belongs to a family of cytoplasmic tyrosine kinases that play a key role in tumor initiation and progression. Src activation has been associated with a more aggressive neoplastic phenotype and induces resistance to platinum agents in preclinical models. The aim of our study was to assess the prognostic and/or predictive value of Src activation in stage II-III colon cancer patients. pSrc expression was assessed in paraffin-embedded tumor samples by immunohistochemistry (phospho Y418, ab4816, Abcam). Cases were classified by staining intensity in four categories: no staining (0), weak (1+), moderate (2+) and intense (3+) staining...
June 7, 2017: Human Pathology
Yoh Dobashi, Hiroyoshi Tsubochi, Kentaro Minegishi, Masatoshi Kitagawa, Shinichi Otani, Akishi Ooi
Downregulation of cyclin-dependent kinase inhibitor protein p27, due to enhanced degradation, is frequently observed in various cancers. The ubiquitin ligases that mediate this degradation have been identified as S-phase kinase-associated protein-2 (Skp2), Kip1 ubiquitylation-promoting complex (KPC), and p53-inducible protein with RING-H2 domain (Pirh2) as well. We investigated the correlation among expression of these 3 ligases and p27 status in surgical specimens of human lung carcinomas by immunohistochemical analysis...
June 7, 2017: Human Pathology
Lingwei Shen, Yun Qian, Weigen Wu, Tianhao Weng, Frederick X C Wang, Bo Hong, Zhigang Wu, Qi Wang, Yiwen Sang, Hong Zhang, Xinhui Zhou, Hangping Yao
B7-H4 belongs to the immune costimulatory B7 family and is thought to negatively regulate T-cell mediated immunity, and may contribute an important role in tumor immune evasion. Although the expression of B7-H4 has been observed in human pancreatic cancer, the prognostic significance of this expression is poorly understood. This present study explored the prognostic value of B7-H4 in pancreatic cancer. Patients with pancreatic cancer and healthy controls were recruited at the Second Affiliated Hospital to Zhejiang University from January 2011 to December 2014...
June 6, 2017: Human Pathology
Adel K El-Naggar, John Chan, Takashi Takata, Jennifer Grandis, Pieter Slootweg
No abstract text is available yet for this article.
June 2, 2017: Human Pathology
Mariana M Cajaiba, Paula E North, Shunyou Gong, Paul S Dickman, Elizabeth Mroczek-Musulman, David A Sauer, Elizabeth J Perlman
Renal vascular lesions (RVL) are rare and their morphological spectrum remains largely unknown, particularly in children. In this study, we characterize the clinicopathological features of RVL in a cohort of twelve children. Seven lesions were classified as previously recognized entities: vascular malformations (four), papillary endothelial hyperplasia (two), and pyogenic granuloma (lobular capillary hemangioma) (one). An eighth lesion showed nonspecific findings which were interpreted as reactive during our review...
May 26, 2017: Human Pathology
Yingying Chen, Shuo Wang, Zhixian He, Fulan Sun, Yeqing Huang, Qichao Ni, Hua Wang, Yingying Wang, Chun Cheng
Dyrk1B, also called minibrain-related kinase (Mirk), is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (Dyrk)/minibrain family of dual-specificity protein kinases. It is a serine/threonine kinase involved in the regulation of tumor progression and cell proliferation. In this study, the role of Dyrk1B in breast cancer development was investigated. The expression of Dyrk1B was detected by Western blot and immunohistochemistry staining, both of which demonstrated that Dyrk1B was overexpressed in breast cancer tissues and cells...
May 26, 2017: Human Pathology
Lingxin Zhang, Chen Yang, James S Lewis, Samir K El-Mofty, Rebecca D Chernock
Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm that most commonly occurs in cervical lymph nodes. It has histologic and clinical overlap with the much more common p16-positive human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx which characteristically has nonkeratinizing morphology and often presents as an isolated neck mass. Not surprisingly, follicular dendritic cell sarcomas are commonly misdiagnosed as squamous cell carcinoma. Immunohistochemistry is helpful in separating the two entities...
May 26, 2017: Human Pathology
Lanqing Cao, Ping-Li Sun, Min Yao, Shifan Chen, Hongwen Gao
Most cervical low-grade squamous intraepithelial lesions (LSILs) do not progress to high-grade squamous intraepithelial lesions (HSILs); however, reliable biomarkers that predict LSIL progression are lacking. We investigated the association of cytokeratin 7 (CK7), human papillomavirus-L1 capsid protein (HPV-L1), and koilocytosis with clinical outcomes of patients with LSIL. CK7, HPV-L1, Ki67, and p16-INK4A expression was determined in 72 cervical LSIL and 28 HSIL biopsy samples; koilocytosis was evaluated by reviewing biopsy slides...
May 26, 2017: Human Pathology
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