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Human Pathology

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https://www.readbyqxmd.com/read/27916625/validation-of-the-prognostic-role-of-the-helsinki-score-in-225-cases-of-adrenocortical-carcinoma
#1
Eleonora Duregon, Rocco Cappellesso, Valeria Maffeis, Barbara Zaggia, Laura Ventura, Alfredo Berruti, Massimo Terzolo, Ambrogio Fassina, Marco Volante, Mauro Papotti
Adrenocortical carcinoma patient prognosis is extremely variable and poorly predictable. The newly introduced Helsinki Score is the first so far proposed diagnostic and prognostic system based on the combined evaluation of morphological (mitoses and necrosis) and immunohistochemical (Ki-67) parameters. The aim of the study was to validate the prognostic role of the Helsinki Score for adrenocortical carcinoma characterization. Thus, 225 adrenocortical carcinomas were reclassified using the Weiss Score and the Helsinki Score (3× mitotic count +5× necrosis + Ki-67 index)...
December 1, 2016: Human Pathology
https://www.readbyqxmd.com/read/27916624/primary-paranasal-sinus-clear-cell-carcinoma-with-ewsr1-atf1-fusion-report-of-two-molecularly-confirmed-cases-exhibiting-unique-histopathology
#2
Jui Lan, Shun-Chen Huang, Yi-Hsien Chen, Wei-Chih Chen, Ying-Tai Jin, Ying-Chou Lu, Chih-Yen Chien, Hsuan-Ying Huang
Hyalinizing clear cell carcinoma (HCCC) is a rare low-grade tumor of the salivary glands made up of clear cells that form cords and nests in hyalinized stroma. To date, primary HCCCs of the paranasal sinus have not been described. This article presents two cases of HCCC of the maxillary sinus with unusual glandular formation and lymphoplasmacytic stroma in Case 1 and a characteristic solid nest pattern and fibrocellular and hyalinized stroma in Case 2. Immunohistochemical studies excluded myoepithelial origin and sinonasal renal cell-like adenocarcinomas...
December 1, 2016: Human Pathology
https://www.readbyqxmd.com/read/27867103/lymphoblastic-lymphoma-with-a-triple-hit-profile-a-rare-but-distinct-and-relevant-entity
#3
Laura S Hiemcke-Jiwa, Roos J Leguit, Lars T van der Veken, Arjan Buijs, Jan Willem Leeuwis, Mirthe de Boer, N Mehdi Jiwa, Andries C Bloem, Eefke J Petersen, Roel A de Weger, Manon M H Huibers
Follicular lymphoma with progression to a high grade lymphoma bears a poor prognosis. We describe a case of a 60-year old man who presented in 2012 with an epidural mass, diagnosed as a diffuse large B-cell lymphoma (DLBCL) with concurrent low grade follicular lymphoma. Three years later, the patient presented with a cervical mass, diagnosed as a lymphoblastic lymphoma (LBL). Both the DLBCL and LBL contained a "triple hit" with BCL2, BCL6 and cMYC translocations demonstrated by fluorescence in situ hybridization analysis and a complex karyotype by SNP-array analysis...
November 17, 2016: Human Pathology
https://www.readbyqxmd.com/read/27865795/hepatic-angiomyolipomas-may-overexpress-tfe3-but-have-no-relevant-genetic-alterations
#4
Naoe Jimbo, Takashi Nishigami, Masayuki Noguchi, Hiroko Iijima, Seiichi Hirota, Takuma Tajiri, Takeshi Inoue, Takanori Hirose, Tomoo Itoh, Yoh Zen
The fusion or amplification of TFE3 has been identified as one of the molecular events underlying tumorigenesis in perivascular epithelioid cell tumors (PEComas). TFE3 rearrangements in PEComas are related to the morphological features of the epithelioid appearance and weaker expression of immunohistochemical muscular markers. This study aimed to clarify whether these genetic alterations are involved in hepatic angiomyolipomas (AMLs), which are a member of the PEComa tumor family. We examined 28 liver specimens (15 biopsies and 13 surgical specimens) of hepatic AMLs obtained from 26 patients...
November 16, 2016: Human Pathology
https://www.readbyqxmd.com/read/27865794/mutations-of-cancer-related-genes-in-benign-tumors-the-example-of-hidradenoma-papilliferum
#5
LETTER
Nicole Pfarr, Albrecht Stenzinger
No abstract text is available yet for this article.
November 16, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864125/solid-pseudopapillary-tumor-a-new-tumor-entity-in-the-testis
#6
LETTER
Maria Cecilia Mengoli, Luca Reggiani Bonetti, Donatella Intersimone, Franco Fedeli, Giulio Rossi
No abstract text is available yet for this article.
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864124/cd133-expression-in-well-differentiated-pancreatic-neuroendocrine-tumors-a-potential-predictor-of-progressive-clinical-courses
#7
Yasuhiro Sakai, Seung-Mo Hong, Soyeon An, Joo Young Kim, Denis Corbeil, Jana Karbanová, Kyoko Otani, Kohei Fujikura, Ki-Byung Song, Song Cheol Kim, Masayuki Akita, Yoshihide Nanno, Hirochika Toyama, Takumi Fukumoto, Yonson Ku, Takanori Hirose, Tomoo Itoh, Yoh Zen
The present study aimed to elucidate whether the stemness molecule, CD133, is expressed in well-differentiated pancreatic neuroendocrine tumors (PanNETs; WHO grades 1 and 2) and establish its clinical relevance using two separate cohorts. In the first series (n=178) in which tissue microarrays were available, immunohistochemistry revealed that CD133 was expressed in 14 cases (8%). CD133+ PanNETs had higher TNM stages (P<.01), more frequent lymphovascular invasion (P=.01), and higher recurrence rates (P=...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864123/pten-pi3k-akt-protein-expression-is-related-to-clinicopathologic-features-and-prognosis-in-breast-cancer-with-axillary-lymph-node-metastases
#8
Ling-Li Wang, Shuai Hao, Shu Zhang, Ling-Ji Guo, Chun-Yan Hu, Gang Zhang, Bo Gao, Jian-Jie Zhao, Yan Jiang, Wu-Guo Tian, Jun Wang, Dong-Lin Luo
We explored the relations between PTEN/PI3K/AKT expression and clinicopathologic characteristics and prognosis in breast cancer patients with and without axillary lymph node metastasis (LNM). Tissues and follow-up data from 142 patients with (LNM group) and 154 without (non-LNM group) metastases were collected. Expression of PTEN/PI3K/AKT was detected using immunohistochemistry staining. With axillary LNM, the positive rate of PTEN was reduced, whereas that of PI3K and AKT was increased. Expression of AKT was negatively correlated with PTEN expression but positively correlated with PI3K expression...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864122/sclerosing-tfeb-rearrangement-renal-cell-carcinoma-a-recurring-histologic-pattern
#9
Sean R Williamson, John N Eble, Nallasivam Palanisamy
Renal cell carcinoma with TFEB rearrangement [t(6;11)(p21;q13)] was initially recognized to be composed of dual populations of large cells with clear cytoplasm and small cells forming rosettes around hyaline material. With increasing awareness, however, the spectrum of described morphology has been found to be more heterogeneous. We report a 54 year-old woman who underwent partial nephrectomy for a 2.4 cm renal mass, composed of fibrosis, hyalinization, calcification and ossification, and a smaller component of epithelioid cells...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864121/gene-amplification-of-ccne1-ccnd1-and-cdk6-in-gastric-cancers-detected-by-multiplex-ligation-dependent-probe-amplification-and-fluorescence-in-situ-hybridization
#10
Akishi Ooi, Takeru Oyama, Ritsuko Nakamura, Ryousuke Tajiri, Hiroko Ikeda, Sachio Fushida, Yoh Dobashi
New and effective treatments for advanced gastric cancer are urgently needed. Cyclins E and D1 form a complex with cyclin-dependent kinase 2 (CDK2), 4 or 6 to regulate G1-S transition. The G1-S regulatory genes encoding cyclin E (CCNE1), cyclin D1 (CCND1) and CDK6 (CDK6) are frequently amplified in gastric cancer and may therefore influence molecularly targeted therapies against ERBB2 or EGFR when co-amplified. A total of 179 formalin-fixed and paraffin-embedded gastric cancer specimens were examined for these gene amplifications by multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH)...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864120/epidermal-growth-factor-receptor-as-an-adverse-survival-predictor-in-squamous-cell-carcinoma-of-the-penis
#11
Alice Muglia Thomaz da Silva Amancio, Isabela Werneck da Cunha, José Ivanildo Neves, Josiane da Silva Quetz, Dirce Maria Carraro, Rafael Malagoli Rocha, Stenio Cássio Zequi, Antonio Leopoldo Cubilla, Francisco Paulo da Fonseca, Ademar Lopes, Maria do Perpétuo Socorro Saldanha da Cunha, Marcos Venício Alves Lima, José Vassallo, Gustavo Cardoso Guimarães, Fernando Augusto Soares
Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted therapy in PC patients, although there is no test that provides accurate patient selection. The aim of the present study was to evaluate the prognostic value of EGFR gene and protein status in tumor samples from patients with primary penile squamous cell carcinoma (SCC)...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864119/role-of-mir-139-as-a-surrogate-marker-for-tumor-aggression-in-breast-cancer
#12
Hongyan Dai, Dan Gallagher, Sarah Schmitt, Ziyan Y Pessetto, Fang Fan, Andrew K Godwin, Ossama Tawfik
MicroRNAs (miRNAs) are non-protein coding molecules that play a key role in oncogenesis, tumor progression and metastasis in many types of malignancies including breast cancer. In the current study, we studied the expression of miRNA-139-5p (miR-139) in invasive ductal carcinoma (IDC) of the breast and correlated its expression with tumor grade, molecular subtype, hormonal status, human epidermal growth factor receptor 2 (HER2) status, proliferation index, tumor size, lymph node status, patient's age and overall survival in 74 IDC cases...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864118/azzopardi-phenomenon-reported-in-metal-on-metal-arthroplasties-is-in-fact-iron-encrustation-of-blood-vessels
#13
LETTER
Sonali Natu, David J Langton, Raghavendra P Sidaginamale
No abstract text is available yet for this article.
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864117/microcystic-elongated-and-fragmented-melf-pattern-invasion-is-mainly-associated-with-isolated-tumor-cell-pattern-metastases-in-figo-grade-i-endometrioid-endometrial-cancer-eec
#14
Mathieu P Pelletier, Vincent Q Trinh, Philippe Stephenson, Anne-Marie Mes-Masson, Vanessa Samouelian, Diane M Provencher, Kurosh Rahimi
While many studies have evaluated the impact of mismatch repair protein loss of expression (MMR LOE) or microcystic, elongated and fragmented (MELF) pattern of myometrial invasion as individual factors in endometrial cancer, we analyzed the combined impact of both. We reviewed every case of FIGO grade 1 endometrioid endometrial cancers (EEC) from our institution, between 2011 and 2015, that had a sentinel lymph node biopsy and/or a lymphadenectomy, and examined the following data: age, myometrial infiltration, MELF infiltration, lymphovascular space invasion and lymph node status...
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27864116/solid-pseudopapillary-tumor-a-new-tumor-entity-in-the-testis-reply
#15
LETTER
Kvetoslava Michalova, Michael Michal, Dmitry V Kazakov, Michal Michal
No abstract text is available yet for this article.
November 15, 2016: Human Pathology
https://www.readbyqxmd.com/read/27836787/tumor-budding-at-the-invasive-front-of-colorectal-cancer-may-not-be-associated-with-the-epithelial-mesenchymal-transition
#16
Noriyuki Yamada, Tamotsu Sugai, Makoto Eizuka, Koudai Tsuchida, Ryo Sugimoto, Yoshiharu Mue, Masamichi Suzuki, Mitsumasa Osakabe, Noriyuki Uesugi, Kazuyuki Ishida, Kouki Otsuka, Takayuki Matsumoto
Tumor budding is thought to reflect the epithelial-mesenchymal transition (EMT). However, the molecular mechanism linking tumor buds and the EMT remains unclear. Here, we examined the induction of tumor budding and EMT and their association with EMT-related proteins (ZEB1, TWIST, SNAIL and SLUG) in colorectal cancer (CRC). Immunohistochemical expression of pan-cytokeratin was examined for identification of tumor budding in 101 CRCs. Grading of tumor budding was classified into low and high grade groups. Tissue micro-array was conducted to identify tumor budding sites...
November 8, 2016: Human Pathology
https://www.readbyqxmd.com/read/27825812/tsap6-is-a-novel-candidate-marker-of-poor-survival-in-metastatic-high-grade-serous-carcinoma
#17
Esther Channah Broner, Claes G Tropé, Reuven Reich, Ben Davidson
The objective of this study was to analyze the expression and clinical role of molecules involved in exosome synthesis and secretion in high-grade serous carcinoma (HGSC), with focus on malignant effusions. The mRNA expression levels of ARF6, nSMase2, TSAP6, Rab27a and Rab27b by qRT-PCR were analyzed in 103 HGSC effusions and 65 solid specimens (35 ovarian, 30 abdominal metastases). Protein expression of ARF6, nSMase2, TSAP6 and Rab27a by Western blotting was analyzed in 150 specimens (94 effusions, 29 ovarian carcinomas, 27 solid metastases)...
November 4, 2016: Human Pathology
https://www.readbyqxmd.com/read/27825811/superficial-acral-fibromyxoma-clinicopathologic-immunohistochemical-and-molecular-study-of-11-cases-highlighting-frequent-rb1-loss-deletions
#18
Abbas Agaimy, Michael Michal, Johannes Giedl, Ladislav Hadravsky, Michal Michal
Superficial acral fibromyxoma (SAF) is an uncommon benign dermal mesenchymal lesion of adults with predilection for acral sites, in particular the nail region. To date, <300 cases have been reported. SAFs consistently express CD34 but other diagnostic markers or specific genetic alterations have not been established yet. We describe 11 SAFs occurring in 7 males and 4 females aged 37 to 86years (median, 48). Mean size was 6mm (range, 4-20mm). Affected sites were fingers (n=5), toes (n=3), heel (n=1), calf (n=1) and unspecified digit (n=1)...
November 4, 2016: Human Pathology
https://www.readbyqxmd.com/read/27825810/dss1-promoter-hypomethylation-and-overexpression-predict-poor-prognosis-in-melanoma-and-squamous-cell-carcinoma-patients
#19
Mario Venza, Maria Visalli, Teresa Catalano, Concetta Beninati, Diana Teti, Isabella Venza
Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved. Evaluation of DSS1 expression profile indicated that the gene is overexpressed in 112/130 cutaneous melanomas (86.1%), 41/64 uveal melanomas (64.1%), 67/82 mucosal melanomas (81.7%), and 61/75 SCC samples (81...
November 4, 2016: Human Pathology
https://www.readbyqxmd.com/read/27818289/hpip-expression-predicts-chemoresistance-and-poor-clinical-outcomes-in-patients-with-epithelial-ovarian-cancer
#20
Yao Wang, Mingxun Li, Fanling Meng, Ge Lou
This study aims to investigate the expression of HPIP, the Hematopoietic pre-B cell leukemia transcription factor (PBX)-interacting protein, and its association with platinum resistance in epithelial ovarian cancer (EOC). The protein expression of HPIP was analyzed by immunohistochemistry in 248 patients with EOC. Furthermore, we analyzed the association between HPIP expression and clinicopathological features including prognosis in EOC samples. High HPIP expression was correlated with platinum resistance in EOCs...
November 3, 2016: Human Pathology
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