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HIV Medicine

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https://www.readbyqxmd.com/read/28070923/the-cascade-of-hiv-care-among-refugees-and-nationals-in-nakivale-refugee-settlement-in-uganda
#1
K N O'Laughlin, J Kasozi, D J Rabideau, R A Parker, E Mulogo, Z M Faustin, K E Greenwald, S Doraiswamy, R P Walensky, I V Bassett
OBJECTIVES: Refugees living in Uganda come from HIV-endemic countries, and many remain in refugee settlements for over a decade. Our objective was to evaluate the HIV care cascade in Nakivale Refugee Settlement and to assess correlates of linkage to care. METHODS: We prospectively enrolled individuals accessing clinic-based HIV testing in Nakivale Refugee Settlement from March 2013 to July 2014. Newly HIV-diagnosed clients were followed for 3 months post-diagnosis...
January 10, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28035766/impact-of-immigration-on-hiv-mother-to-child-transmission-in-western-europe
#2
LETTER
A Soriano-Arandes, A Noguera-Julian, C Fortuny
No abstract text is available yet for this article.
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28035758/genotypic-tropism-testing-of-proviral-dna-to-guide-maraviroc-initiation-in-aviraemic-subjects-48-week-analysis-of-results-from-the-protest-study
#3
E Poveda, J Hernández-Quero, M J Pérez-Elías, M A Ribas, O J Martínez-Madrid, J Flores, J Navarro, F Gutiérrez, M García-Deltoro, A Imaz, A Ocampo, A Artero, F Blanco, E Bernal, J Pasquau, C Mínguez-Gallego, N Pérez, A Aiestaran, F García, R Paredes
OBJECTIVES: Maraviroc (MVC) is a suitable drug for aviraemic subjects on antiretroviral treatment (ART) developing toxicity. Its prescription requires prior tropism testing. It is unknown if proviral DNA genotypic tropism testing is reliable for guiding MVC initiation in aviraemic subjects, so this study was carried out to address this issue. METHODS: PROTEST was a phase 4, prospective, single-arm clinical trial carried out in 24 HIV care centres in Spain. MVC-naïve HIV-1-infected patients with HIV-1 RNA < 50 copies/mL on stable ART during the previous 6 months who required an ART change because of toxicity and who had R5 HIV, as determined by proviral DNA genotypic tropism testing, initiated MVC with two nucleoside reverse transcriptase inhibitors (NRTIs) and were followed for 48 weeks...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28035738/predictors-for-and-coverage-of-influenza-vaccination-among-hiv-positive-patients-a-cross-sectional-survey
#4
N Harrison, W Poeppl, H Herkner, K D Tillhof, K Grabmeier-Pfistershammer, A Rieger, C Forstner, H Burgmann, H Lagler
OBJECTIVES: Influenza vaccination is recommended for HIV-infected patients, but limited data about vaccination rates are available. The aim of this study was to evaluate the coverage of and predictors for influenza vaccination among HIV-positive patients. METHODS: All HIV-positive patients who visited the HIV out-patient department of the University Hospital of Vienna, Austria, between June and August 2015 were asked to participate in this survey by completing a questionnaire...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28004523/accuracy-of-self-report-of-hiv-viral-load-among-people-with-hiv-on-antiretroviral-treatment
#5
J Sewell, M Daskalopoulou, F Nakagawa, F C Lampe, S Edwards, N Perry, E Wilkins, R O'Connell, M Jones, S Collins, A Speakman, A N Phillips, A J Rodger
OBJECTIVES: The aim of the study was to assess, among people living with HIV, knowledge of their latest HIV viral load (VL) and CD4 count. METHODS: Agreement between self-report and clinic record was assessed among 2771 HIV-diagnosed individuals on antiretroviral treatment (ART) in the UK Antiretrovirals, Sexual Transmission Risk and Attitudes Study (2011-2012). A confidential self-completed questionnaire collected information on demographic, socioeconomic, HIV-related and health-related factors...
December 22, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000390/an-oral-formulation-of-efavirenz-loaded-lactoferrin-nanoparticles-with-improved-biodistribution-and-pharmacokinetic-profile
#6
P Kumar, Y S Lakshmi, A K Kondapi
OBJECTIVES: Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, is a drug that is frequently included in highly active antiretroviral therapy for treatment of HIV infection. Decreased bioavailability and increased toxicity limit its use. We report a formulation of efavirenz-loaded lactoferrin nanoparticles (lacto-EFV-nano) for oral delivery which exhibited significantly improved pharmacological properties coupled with reduced toxicity compared with its free form. METHODS: Lacto-EFV-nano was prepared using the Sol-oil protocol and characterized using various sources of characterization...
December 21, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000379/rate-correlates-and-outcomes-of-repeat-pregnancy-in-hiv-infected-women
#7
M Floridia, E Tamburrini, G Masuelli, P Martinelli, A Spinillo, G Liuzzi, A Vimercati, S Alberico, A Maccabruni, C Pinnetti, V Frisina, S Dalzero, M Ravizza
OBJECTIVES: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. METHODS: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. RESULTS: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs...
December 21, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000358/a-feasibility-study-for-a-clinical-decision-support-system-prompting-hiv-testing
#8
D R Chadwick, C Hall, C Rae, Ml Rayment, M Branch, J Littlewood, A Sullivan
OBJECTIVES: Levels of undiagnosed HIV infection and late presentation remain high globally despite attempts to increase testing. The objective of this study was to evaluate a risk-based prototype application to prompt HIV testing when patients undergo routine blood tests. METHODS: Two computer physician order entry (CPOE) systems were modified using the application to prompt health care workers (HCWs) to add an HIV test when other tests selected suggested that the patient was at higher risk of HIV infection...
December 21, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000338/opt-out-screening-strategy-for-hiv-infection-among-patients-attending-emergency-departments-systematic-review-and-meta-analysis
#9
C Henriquez-Camacho, P Villafuerte-Gutierrez, J A Pérez-Molina, J Losa, E Gotuzzo, N Cheyne
OBJECTIVES: International health agencies have promoted nontargeted universal (opt-out) HIV screening tests in different settings, including emergency departments (EDs). We performed a systematic review and meta-analysis to assess the testing uptake of strategies (opt-in targeted, opt-in nontargeted and opt-out) to detect new cases of HIV infection in EDs. METHODS: We searched the Pubmed and Embase databases, from 1984 to April 2015, for opt-in and opt-out HIV diagnostic strategies used in EDs...
December 21, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27981723/microrna-155-is-a-biomarker-of-t-cell-activation-and-immune-dysfunction-in-hiv-1-infected-patients
#10
C Jin, L Cheng, S Höxtermann, T Xie, X Lu, H Wu, A Skaletz-Rorowski, N H Brockmeyer, N Wu
OBJECTIVES: MicroRNA-155 (miR-155) regulates T-cell differentiation and activation. It has also been associated with HIV infection. However, it remains unclear whether miR-155 is related to the T-cell response in HIV-infected individuals (e.g. T-cell activation and exhaustion). METHODS: We performed a cross-sectional study involving 121 HIV-1-infected patients on highly active antiretroviral therapy (HAART) and 43 HAART-naïve patients. MiR-155 levels in the peripheral blood were determined by quantitative reverse transcription-polymerase chain reaction (PCR)...
December 16, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27981720/off-licence-use-of-once-daily-maraviroc-in-children-and-adolescents-with-perinatally-acquired-hiv-1-infection
#11
LETTER
T Fraser-Taliente, N E Mackie, S Kaye, M Nyirenda, C Foster
No abstract text is available yet for this article.
December 16, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27882706/high-frequency-of-potential-interactions-between-direct-acting-antivirals-and-concomitant-therapy-in-hiv-hepatitis-c-virus-coinfected-patients-in-clinical-practice
#12
J Macías, P Monge, M Mancebo, N Merchante, K Neukam, L M Real, J A Pineda
OBJECTIVES: The aim of the study was to analyse the frequency and degree of potential drug-drug interactions (DDIs) between direct-acting antivirals (DAAs) and concomitant medication used by HIV/hepatitis C virus (HCV)-coinfected patients, including antiretroviral therapy (ART) and other drugs. METHODS: All patients with HIV infection and viraemic HCV genotype 1, 3 or 4 coinfection attending a tertiary care centre in Spain (November 2014 to November 2015) were included in the study...
November 24, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27862854/pregnancies-in-older-women-living-with-hiv-in-the-uk-and-ireland
#13
C L Townsend, A de Ruiter, H Peters, C Nelson-Piercy, P Tookey, C Thorne
OBJECTIVES: The aim of the study was to compare maternal characteristics and pregnancy outcomes in women aged < 40 years and ≥ 40 years in a large unselected population of HIV-positive women delivering in the UK and Ireland between 2000 and 2014. METHODS: Comprehensive population-based surveillance data on all HIV-positive pregnant women and their children seen for care in the UK and Ireland are collected through the National Study of HIV in Pregnancy and Childhood...
November 16, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27860212/alcohol-and-dietary-factors-associate-with-gut-integrity-and-inflammation-in-hiv-infected-adults
#14
A R Webel, A Sattar, N T Funderburg, B Kinley, C T Longenecker, D Labbato, Sm Khurshid Alam, G A McComsey
OBJECTIVES: HIV-infected adults have heightened monocyte activation and inflammation, at least partially as a consequence of altered gut integrity. The role of dietary factors in microbial translocation and inflammation and their downstream effect on markers of cardiovascular disease (CVD) have not been explored. Our purpose was to describe the longitudinal dietary patterns of HIV-infected adults, and to examine the relationship between dietary intake, gut integrity, inflammation and subclinical markers of CVD in HIV-infected adults...
November 9, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27785907/associations-between-cognitive-impairment-and-patient-reported-measures-of-physical-mental-functioning-in-older-people-living-with-hiv
#15
J Underwood, D De Francesco, F A Post, J H Vera, I Williams, M Boffito, P W Mallon, J Anderson, M Sachikonye, C Sabin, A Winston
OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState(™) ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 years participating in the Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study...
October 26, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27785892/hepatitis-c-virus-hcv-rna-profiles-among-chronic-hiv-hcv-coinfected-individuals-in-esprit-spontaneous-hcv-rna-clearance-observed-in-nine-individuals
#16
D Grint, E Tedaldi, L Peters, A Mocroft, B Edlin, S Gallien, H Klinker, C Boesecke, P Kokordelis, J K Rockstroh
OBJECTIVES: Studies have shown that hepatitis C virus (HCV) RNA levels remain stable over time in HIV/HCV-coinfected individuals taking combination antiretroviral therapy (cART), while spontaneous clearance of HCV RNA during the persistent infection phase has been documented only rarely among those with the CC interleukin (IL)-28B genotype. This study describes HCV RNA profiles and factors associated with changes over time in HCV RNA levels in the ESPRIT study. METHODS: HIV/HCV-coinfected individuals positive for HCV RNA were included in the study...
October 26, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27905675/asking-advice-the-need-for-specialist-dermatologists-in-hiv-units
#17
LETTER
M Noy, E E Merika, N Morar, M Nelson, L C Fuller
No abstract text is available yet for this article.
January 2017: HIV Medicine
https://www.readbyqxmd.com/read/27905674/screening-for-intimate-partner-violence-in-a-london-hiv-clinic-characteristics-of-those-screening-positive
#18
LETTER
S Madge, C Smith, C Warren-Gash, J Bayly, A Bartley
No abstract text is available yet for this article.
January 2017: HIV Medicine
https://www.readbyqxmd.com/read/27860104/higher-rates-of-neuropsychiatric-adverse-events-leading-to-dolutegravir-discontinuation-in-women-and-older-patients
#19
C Hoffmann, T Welz, M Sabranski, M Kolb, E Wolf, H-J Stellbrink, C Wyen
OBJECTIVES: Dolutegravir (DTG), a second-generation integrase strand transfer inhibitor (INSTI), is now among the most frequently used antiretroviral agents. However, recent reports have raised concerns about potential neurotoxicity. METHODS: We performed a retrospective analysis of a cohort of HIV-infected patients who had initiated an INSTI in two large German out-patient clinics between 2007 and 2016. We compared discontinuation rates because of adverse events (AEs) within 2 years of starting treatment with dolutegravir, raltegravir or elvitegravir/cobicistat...
January 2017: HIV Medicine
https://www.readbyqxmd.com/read/27625009/reference-curves-for-cd4-t-cell-count-response-to-combination-antiretroviral-therapy-in-hiv-1-infected-treatment-na%C3%A3-ve-patients
#20
V Bouteloup, C Sabin, A Mocroft, L Gras, N Pantazis, V Le Moing, A d'Arminio Monforte, M Mary-Krause, B Roca, J M Miro, M Battegay, N Brockmeyer, J Berenguer, P Morlat, N Obel, S De Wit, G Fätkenheuer, R Zangerle, J Ghosn, S Pérez-Hoyos, M Campbell, M Prins, G Chêne, L Meyer, M Dorrucci, C Torti, R Thiébaut
OBJECTIVES: The aim of this work was to provide a reference for the CD4 T-cell count response in the early months after the initiation of combination antiretroviral therapy (cART) in HIV-1-infected patients. METHODS: All patients in the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) cohort who were aged ≥ 18 years and started cART for the first time between 1 January 2005 and 1 January 2010 and who had at least one available measurement of CD4 count and a viral load ≤ 50 HIV-1 RNA copies/mL at 6 months (± 3 months) after cART initiation were included in the study...
January 2017: HIV Medicine
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