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HIV Medicine

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https://www.readbyqxmd.com/read/28857427/the-extent-of-b-cell-activation-and-dysfunction-preceding-lymphoma-development-in-hiv-positive-people
#1
L Shepherd, Á H Borges, R Harvey, M Bower, A Grulich, M Silverberg, J Weber, M Ristola, J-P Viard, J R Bogner, P Gargalianos-Kakolyris, C Mussini, K Mansinho, I Yust, D Paduta, D Jilich, T Smiatacz, R Radoi, J Tomazic, P Plomgaard, R Frikke-Schmidt, J Lundgren, A Mocroft
OBJECTIVES: B-cell dysfunction and activation are thought to contribute to lymphoma development in HIV-positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B-cell dysfunction [free light chain (FLC)-κ, FLC-λ, immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV-positive people. METHODS: A nested matched case-control study was carried out within the EuroSIDA cohort, including 73 HIV-positive people with lymphoma and 143 HIV-positive lymphoma-free controls...
August 31, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28851009/reply-to-letter-morning-dosing-for-dolutegravir-related-insomnia-and-sleep-disorders-by-capetti-et%C3%A2-al
#2
LETTER
C Hoffmann, T Welz, M Sabranski, M Kolb, E Wolf, H-J Stellbrink, C Wyen
No abstract text is available yet for this article.
August 29, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28833949/argon-plasma-coagulation-treatment-of-anal-high-grade-squamous-intraepithelial-lesions-in-men-who-have-sex-with-men-living-with-hiv-results-of-a-2-year-prospective-pilot-study
#3
A de Pokomandy, D Rouleau, R Lalonde, C Beauvais, C de Castro, F Coutlée
OBJECTIVES: Men who have sex with men (MSM) living with HIV are at high risk for anal high-grade squamous intraepithelial lesions (HSILs) and cancer. The best management of anal HSIL remains unclear. Our objective was to assess whether argon plasma coagulation (APC) could be safe, well tolerated and efficient to treat anal HSILs in MSM living with HIV. METHODS: A prospective phase II, open-label, pilot study was conducted to evaluate APC to treat anal HSILs in 20 HIV-positive MSM...
August 23, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28834136/no-relationship-between-late-hiv-diagnosis-and-social-deprivation-in-newly-diagnosed-patients-in-france
#4
L Cuzin, Y Yazdanpanah, T Huleux, L Cotte, P Pugliese, C Allavena, J Reynes, I Poizot-Martin, F Bani-Sadr, C Delpierre
OBJECTIVES: The aim of the study was to determine whether there is a relationship between social deprivation and time of HIV diagnosis in France. METHODS: Prospectively collected data from a multicentre database were used in the study. Patients with a first HIV diagnosis between 1 January 2014 and 31 December 2015 were selected from the database. Deprivation was measured using the European Deprivation Index (EDI), which is an ecological index constructed from the address of residence and based on the smallest geographical census unit, in which individuals are classified so as to be comparable with national quintiles...
August 18, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28815917/hiv-infected-patients-beliefs-about-their-chronic-co-treatments-in-comparison-with-their-combined-antiretroviral-therapy
#5
S Kamal, O Bugnon, M Cavassini, M P Schneider
OBJECTIVES: Thanks to the success of combination antiretroviral therapy (cART), HIV-infected patients can have almost a normal life expectancy. This has resulted in an aging HIV-infected population with other chronic comorbidities such as cardiovascular diseases, osteoporosis, and depression. Our hypothesis is that patients' perceptions of and attitudes towards their cART, which is perceived as crucial to their survival, differ from their beliefs about their co-treatments, and this may have an impact on their medication adherence...
August 16, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28766827/are-fluconazole-or-sertraline-dose-adjustments-necessary-with-concomitant-rifampin
#6
LETTER
R Rajasingham, D B Meya, D R Boulware
No abstract text is available yet for this article.
August 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28762661/morning-dosing-for-dolutegravir-related-insomnia-and-sleep-disorders
#7
LETTER
A F Capetti, S Di Giambenedetto, A Latini, G Sterrantino, I De Benedetto, M V Cossu, A Gori
No abstract text is available yet for this article.
August 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28762652/hiv-incidence-in-the-estonian-population-in-2013-determined-using-the-hiv-1-limiting-antigen-avidity-assay
#8
P Soodla, R Simmons, K Huik, M Pauskar, E-L Jõgeda, H Rajasaar, E Kallaste, M Maimets, R Avi, G Murphy, K Porter, I Lutsar
OBJECTIVES: Estonia has one the highest number of new HIV diagnoses in the European Union, mainly among injecting drug users and heterosexuals. Little is known of HIV incidence, which is crucial for limiting the epidemic. Using a recent HIV infection testing algorithm (RITA) assay, we aimed to estimate HIV incidence in 2013. METHODS: All individuals aged ≥18 years newly-diagnosed with HIV in Estonia January- December 2013, except blood donors and those undergoing antenatal screening, were included...
August 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28758335/discordant-rapid-hiv-tests-lessons-from-a-low-resource-community
#9
A A Adetunji, M A Kuti, R A Audu, S A Muyibi, M Imhansoloeva, O A Mosuro, E A Solanke, O M Akpa, A E Irabor, Mma Ladipo, B Berzins, K Robertson, A Ogunniyi, I F Adewole, B O Taiwo
OBJECTIVES: HIV rapid antibody tests are widely used in Africa, but dual testing sometimes produces discordant results. It is not clear if discordant rapid HIV tests should always heighten suspicion by frontline health workers that early HIV infection is present. Some studies have reported that discordant rapid tests have value for identifying early HIV infection in high HIV prevalence populations. It is not known if rapid test performance influenced this conclusion, or if this observation will hold true for low HIV prevalence populations...
July 31, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28744997/severe-depression-as-a-neuropsychiatric-side-effect-induced-by-dolutegravir
#10
LETTER
H Scheper, N van Holten, Jgfm Hovens, Mgj de Boer
No abstract text is available yet for this article.
July 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28741837/immunological-and-virological-response-to-antiretroviral-treatment-in-migrant-and-native-men-and-women-in-western-europe-is-benefit-equal-for-all
#11
(no author information available yet)
OBJECTIVES: The aim of the study was to evaluate differences in immunovirological response to combination antiretroviral therapy (cART) in migrant and native men and women within a European collaboration of HIV cohorts Collaboration of Observational HIV Epidemiological Research in Europ (COHERE) in EuroCoord, 2004-2013. METHODS: Migrants were defined as those with geographical origin (GO) different from the reporting country and were grouped as originating from Western Europe and Western Countries (WEWC), Eastern Europe (EE), North Africa and the Middle East (NAME), sub-Saharan Africa (SSA), Latin America (LA), Caribbean (CRB) and Asia/Oceania (ASIA/OCE)...
July 25, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28737297/correlates-of-frailty-phenotype-and-frailty-index-and-their-associations-with-clinical-outcomes
#12
G Guaraldi, A Malagoli, O Theou, T D Brothers, Lmk Wallace, R Torelli, C Mussini, S Sartini, S A Kirkland, K Rockwood
OBJECTIVES: Frailty is a predictor of adverse health outcomes and can be measured across the life course, including among people living with HIV. The purpose of this study was to examine two commonly used measures of frailty - the frailty index (FI) and frailty phenotype - to assess common characteristics and to describe associations with multimorbidity, falls, and disability in people aging with HIV. METHODS: This was a cross-sectional observational study including 482 consecutive HIV-infected patients (mean age 53...
July 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28737291/nucleoside-reverse-transcriptase-inhibitor-reducing-strategies-in-hiv-treatment-assessing-the-evidence
#13
REVIEW
C Orkin, J M Llibre, S Gallien, A Antinori, Gmn Behrens, A Carr
Antiretroviral (ARV) therapy, comprising a backbone of two nucleos(t)ide reverse transcriptase inhibitors (NRTIs) plus another ARV, is the recognized standard of care (SOC), which has helped extend life expectancy in people living with HIV. In a quest to reduce lifelong drug exposure and minimize or avoid the toxicity of NRTIs, "NRTI-reducing" regimens have been investigated. This descriptive review assessing the results of NRTI-reducing strategies from the largest randomized trials focuses on virological efficacy, resistance, regimen safety (in terms of bone mineral density, renal function, lipids and central nervous system function) and simplicity...
July 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28719012/the-impact-of-immunoglobulin-in-acute-hiv-infection-on-the-hiv-reservoir-a-randomized-controlled-trial
#14
J Tiraboschi, S Ray, K Patel, A Teague, M Pace, P Phalora, N Robinson, E Hopkins, J Meyerowitz, Y Wang, J Cason, S Kaye, J Sanderson, P Klenerman, S Fidler, J Frater, J Fox
OBJECTIVES: Antiretroviral therapy (ART) during acute HIV infection (AHI) restricts the HIV reservoir, but additional interventions are necessary to induce a cure. Intravenous immunoglobulin (IVIG) is not HIV-specific but is safe and temporarily reduces the HIV reservoir in chronic HIV infection. We present a randomized controlled trial to investigate whether IVIG plus ART in AHI reduces the HIV reservoir and immune activation compared with ART alone. METHODS: Ten men with AHI (Fiebig II-IV) initiated ART (tenofovir, entricitabine, ritonavir boosted darunavir and raltegravir) at HIV-1 diagnosis and were randomized to ART alone or ART plus 5 days of IVIG, once virally suppressed (week 19)...
July 18, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28696029/insurance-status-and-mortality-among-patients-with-aids
#15
A W Jabs, D A Jabs, M L Van Natta, F J Palella, C L Meinert
OBJECTIVES: The aim of the study was to evaluate risk factors for mortality, including health care insurance status, among patients with AIDS in the era of modern combination antiretroviral therapy (cART). METHODS: This study was part of the prospective, multicentre, observational Longitudinal Study of the Ocular Complications of AIDS (LSOCA). Patients were classified as having private health care insurance, Medicare, Medicaid, or no insurance. Hazard ratios (HRs) for death were calculated using proportional hazards regression models and staggered entries, anchored to the AIDS diagnosis date...
July 11, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28675626/epidemiology-of-tuberculosis-and-hiv-coinfections-in-singapore-2000-2014
#16
K Nandar, L W Ang, J Tey, L James, K M Kyi Win, Cbe Chee, O T Ng, J L Cutter, Y T Wang
Cross-matching of records between Singapore's tuberculosis and HIV registries showed that 3.3% of individuals with tuberculosis (TB) were coinfected with HIV (2000-2014), the TB incidence among individuals with HIV infection was 1.65 per 100 person-years, and 53% of coinfections were diagnosed within 1 month of each other. The findings supported joint prevention programmes for early diagnosis and treatment.
July 4, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28671337/significant-improvement-in-triglyceride-levels-after-switching-from-ritonavir-to-cobicistat-in-suppressed-hiv-1-infected-subjects-with-dyslipidaemia
#17
P Echeverría, A Bonjoch, J Puig, A Ornella, B Clotet, E Negredo
OBJECTIVES: Cobicistat seems to have a low rate of adverse events compared with ritonavir. METHODS: This restrospective observational study to evaluated changes in lipid parameters and the percentage of subjects with dyslipidemia in virologically suppressed HIV-infected patients who were receiving a regimen containing darunavir/ritonavir and were then switched from ritonavir to cobicistat, carried out from December 2015 to May 2016, included 299 HIV-1-infected patients who were on stable antiretroviral treatment including darunavir/ritonavir (monotherapy, bitherapy or triple therapy for at least 6 months) and were then switched from ritonavir to cobicistat...
July 3, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28657199/interprep-internet-based-pre-exposure-prophylaxis-with-generic-tenofovir-disoproxil-fumarate-emtrictabine-in-london-analysis-of-pharmacokinetics-safety-and-outcomes
#18
X Wang, N Nwokolo, R Korologou-Linden, A Hill, G Whitlock, I Day-Weber, M O McClure, M Boffito
OBJECTIVES: The National Health Service in England (NHS England) does not provide pre-exposure prophylaxis (PrEP) against HIV, forcing people to purchase generic versions on the internet. However, there are concerns about the authenticity of medicines purchased online. We established an innovative service offering plasma tenofovir (TFV) and emcitrabine (FTC) therapeutic drug monitoring for people buying generic PrEP online, to ensure that drug concentrations in vivo were consistent with those of propriety brands and previously published data...
June 28, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28880486/out-of-focus-tailoring-the-cascade-of-care-to-the-needs-of-women-living-with-hiv
#19
REVIEW
A M Geretti, M Loutfy, A D'Arminio Monforte, I Latysheva, M J Pérez Elías, J Rymer, M Boffito
Around half of the global adult HIV-positive population are women, yet historically women have been under-represented in clinical studies of antiretroviral therapy (ART) and there has been minimal exploration of gender-specific factors related to the response to and appropriateness of treatment choices in women living with HIV (WLWH). There are several key issues pertaining to the cascade of HIV care that make it important to differentiate WLWH from men living with HIV. Factors that are gender specific may impact on the status of WLWH, affecting access to diagnosis and treatment, optimal clinical management, ART outcomes, retention in care, and the overall long-term wellbeing of WLWH...
September 2017: HIV Medicine
https://www.readbyqxmd.com/read/28332270/changes-in-elevated-cholesterol-in-the-era-of-tenofovir-in-south-africa-risk-factors-clinical-management-and-outcomes
#20
L Jamieson, D Evans, A T Brennan, F Moyo, D Spencer, K Mahomed, M Maskew, L Long, S Rosen, M P Fox
OBJECTIVES: Antiretroviral therapy (ART) has been associated with unfavourable lipid profile changes and increased risk of cardiovascular disease (CVD). With a growing population on ART in South Africa, there has been concern about the increase in noncommunicable diseases such as CVD. We determined risk factors associated with increased total cholesterol (TC) in a large cohort on ART and describe the clinical management thereof. METHODS: We conducted an observational cohort study of ART-naïve adults initiating standard first-line ART in a large urban clinic in Johannesburg, South Africa...
September 2017: HIV Medicine
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