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HIV Medicine

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https://www.readbyqxmd.com/read/30430742/late-diagnosis-delayed-presentation-and-late-presentation-among-persons-enrolled-in-a-clinical-hiv-cohort-in-ontario-canada-1999-2013
#1
J Wilton, L Light, S Gardner, B Rachlis, T Conway, C Cooper, P Cupido, C E Kendall, M Loutfy, F McGee, J Murray, J Lush, A Rachlis, W Wobeser, J Bacon, A E Kroch, M Gilbert, S B Rourke, A N Burchell
OBJECTIVES: Timely HIV diagnosis and presentation to medical care are important for treatment and prevention. Our objective was to measure late diagnosis, delayed presentation and late presentation among individuals in the Ontario HIV Treatment Network Cohort Study (OCS) who were newly diagnosed in Ontario. METHODS: The OCS is a multi-site clinical cohort study of people living with HIV in Ontario, Canada. We measured prevalence of late diagnosis [CD4 count < 350 cells/μL or an AIDS-defining condition (ADC) within 3 months of HIV diagnosis], delayed presentation (≥ 3 months from HIV diagnosis to presentation to care), and late presentation (CD4 count < 350 cells/μL or ADC within 3 months of presentation)...
November 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30411475/acute-kidney-injury-in-hiv-infected-patients-a-critical-review
#2
J Gameiro, J Agapito Fonseca, S Jorge, J A Lopes
Acute kidney injury (AKI) is characterized by a rapid decline of renal function associated with worse outcomes. The purpose of the authors is to perform a critical review of the incidence, risk factors, pathogenesis and outcome of AKI in HIV-infected patients. Human immunodeficiency virus (HIV)-infected patients have an increased risk of developing AKI, to which contribute both HIV-dependent and HIV-independent factors as well as the nephrotoxicity of drugs used. The increased risk of AKI in HIV-infected patients and its negative impact on prognosis highlights the need for identification of patients at risk, creation of prevention strategies and management...
November 8, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30402918/risk-of-neurosyphilis-in-hiv-infected-persons-with-syphilis-lacking-signs-or-symptoms-of-central-nervous-system-infection
#3
L Rotman, X Luo, A Thompson, M E Mackesy-Amiti, L R Young, J D Young
OBJECTIVES: People living with HIV (PLWH) are at increased risk of asymptomatic neurosyphilis; thus, it has been common practice to perform a lumbar puncture (LP) in all PLWH presenting with syphilis regardless of stage, signs or symptoms. However, this practice varies widely among clinicians. Our objective was to elucidate the number of LPs required to diagnose a single case of asymptomatic neurosyphilis. METHODS: We performed an electronic health record (EHR) review of PLWH who were diagnosed with syphilis of any stage over a 10-year period...
November 7, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30362282/shedding-light-on-iris-from-pathophysiology-to-treatment-of-cryptococcal-meningitis-and-immune-reconstitution-inflammatory-syndrome-in-hiv-infected-individuals
#4
A Balasko, Y Keynan
OBJECTIVES: The aim of this work was to review current treatment options and propose alternatives for immune reconstitution inflammatory syndrome (IRIS) in HIV-infected individuals with cryptococcal meningitis (CM) (termed 'HIV-CM IRIS'). As a consequence of the immunocompromised state of these individuals, the initial immune response to CM is predominantly type 2 T helper (Th2) /Th17 rather than Th1, leading to inefficient fungal clearance at the time of antiretroviral initiation, and a subsequent overexaggeration of the Th1 response and life-threatening IRIS development...
October 25, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30362279/heterogeneity-of-virological-suppression-in-the-national-antiretroviral-programme-of-cameroon-anrs-12288-evolcam
#5
F Liégeois, S Eymard-Duvernay, S Boyer, G Maradan, C Kouanfack, J Domyeum, V Boyer, E Mpoudi-Ngolé, B Spire, E Delaporte, L Vidal, C Kuaban, C Laurent
OBJECTIVES: In terms of HIV infection, western and central Africa is the second most affected region world-wide, and the gap between the regional figures for the testing and treatment cascade and the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets is particularly worrying. We assessed the prevalence of virological suppression in patients routinely treated in 19 hospitals in Cameroon. METHODS: A cross-sectional survey was performed in adult patients receiving antiretroviral therapy (ART) in the Centre and Littoral regions...
October 25, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30318718/identification-and-characterization-of-hiv-positive-ethiopian-elite-controllers-in-both-africa-and-israel
#6
Y K Kiros, H Elinav, A Gebreyesus, H Gebremeskel, J Azar, D Chemtob, H Abreha, D Elbirt, E Shahar, M Chowers, D Turner, Z Grossman, A Haile, R E Sutton, S L Maayan, D Wolday
OBJECTIVES: HIV elite controllers (ECs) are a unique subgroup of HIV-positive patients who are long-term virologically suppressed in the absence of antiretroviral treatment (ART). The prevalence of this subgroup is estimated to be < 1%. Various cohorts of ECs have been described in developed countries, most of which have been demographically heterogeneous. The aim of this study was to identify ECs in two large African cohorts and to estimate their prevalence in a relatively genetically homogenous population...
October 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30318669/management-of-renal-disease-utility-of-a-joint-hiv-renal-clinic
#7
LETTER
D Williams, J Scott, D Richardson, E Kingdon
No abstract text is available yet for this article.
October 14, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30311440/serum-cryptococcal-antigen-titre-as-a-diagnostic-tool-and-a-predictor-of-mortality-in-hiv-infected-patients-with-cryptococcal-meningitis
#8
J Chen, R Zhang, Y Shen, L Liu, T Qi, Z Wang, V Mehraj, J P Routy, H Lu
OBJECTIVES: The aim was to determine the effectiveness of the serum cryptococcal antigen (CrAg) test in the diagnosis of concurrent cryptococcal meningitis (CM) and as a predictor of mortality in HIV-infected patients. METHODS: In this retrospective study, all HIV-infected patients admitted to Shanghai Public Health Clinical Center from 1 January 2014 to 31 August 2016 were screened for serum CrAg using the latex agglutination test. Serum CrAg-positive patients underwent lumbar puncture to confirm CM prior to the initiation of appropriate antifungal therapy and were followed up for at least 6 months...
October 12, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30270543/predictors-of-virological-failure-in-hiv-1-infected-patients-switching-to-dolutegravir-maintenance-monotherapy
#9
Iea Wijting, S L Rutsaert, C Rokx, D M Burger, A Verbon, Jja van Kampen, Cab Boucher, Bja Rijnders, L Vandekerckhove
OBJECTIVES: The Dolutegravir Monotherapy for HIV (DOMONO; NCT02401828) study showed that maintenance monotherapy with dolutegravir (DTG) is associated with virological failure (VF) and leads to DTG resistance and as a result should not be used. However, data on clinical and virological factors associated with VF during DTG monotherapy are lacking. We identified factors associated with VF during DTG monotherapy. METHODS: A randomized trial was carried out in which patients on combination antiretroviral therapy (cART) with an HIV-1 RNA zenith < 100 000 copies/mL and a CD4 T-cell nadir ≥ 200 cells/μL, who had never experienced VF, switched to DTG monotherapy...
September 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30270502/latent-tuberculosis-infection-screening-in-hiv-infected-patients-guidelines-versus-everyday-practice-in-a-uk-hiv-centre
#10
LETTER
S J Aston, K Doherty, B Black, G Davies
No abstract text is available yet for this article.
September 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30270487/risk-factors-for-loss-to-follow-up-transfer-or-death-among-people-living-with-hiv-on-their-first-antiretroviral-therapy-regimen-in-mali
#11
A Baldé, L Lièvre, A I Maiga, F Diallo, I A Maiga, D Costagliola, S Abgrall
OBJECTIVES: Risk factors for loss to follow-up (LTFU) were assessed for people living with HIV (PLHIV) at various reference out-patient clinics (expertise level II) and hospitals (expertise level III) in Mali. METHODS: HIV-1-positive adults starting antiretroviral therapy (ART) in 2006-2013 were eligible for inclusion. Risk factors for LTFU, defined as no visit in the 6 months preceding the last database update, were assessed with the Cox model, taking into account the competing risks of transfer and death...
September 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30182478/coronary-artery-calcium-and-intima-media-thickness-are-associated-with-level-of-cytomegalovirus-immunoglobulin-g-in-hiv-infected-patients
#12
A Knudsen, U S Kristoffersen, I Panum, Y B Hansen, P D Skottrup, P Hasbak, A Kjaer, A-M Lebech
Coinfection with cytomegalovirus (CMV) may be involved in cardiovascular disease in HIV-infected patients. We found that higher level of CMV immunoglobulin G (IgG) was independently associated with an increased risk of coronary artery calcium and higher intima-media thickness in HIV-infected patients but not in healthy controls after adjustment for other cardiovascular risk factors and levels of herpes viridae IgG.
September 4, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30178911/recurrence-after-hospitalization-for-acute-coronary-syndrome-among-hiv-infected-and-hiv-uninfected-individuals
#13
J L Marcus, L B Hurley, A Prasad, J Zaroff, D B Klein, M A Horberg, A S Go, G N DeLorenze, C P Quesenberry, S Sidney, J C Lo, M J Silverberg
OBJECTIVES: We evaluated the association of HIV infection and immunodeficiency with acute coronary syndrome (ACS) recurrence, and with all-cause mortality as a secondary outcome, after hospitalization for ACS among HIV-infected and HIV-uninfected individuals. METHODS: We conducted a retrospective cohort study within Kaiser Permanente Northern California of HIV-infected and HIV-uninfected adults discharged after ACS hospitalization [types: ST-elevation myocardial infarction (STEMI), non-STEMI, or unstable angina] during 1996-2010...
September 4, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30160367/a-structural-equation-model-to-predict-pre-exposure-prophylaxis-acceptability-in-men-who-have-sex-with-men-in-leicester-uk
#14
R Jaspal, B Lopes, J Bayley, P Papaloukas
OBJECTIVES: Pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool for high-risk men who have sex with men (MSM). However, acceptability and uptake have been variable. This study explored the factors that predict PrEP acceptability in MSM in Leicester, where HIV prevalence is double the national average. METHODS: A total of 191 HIV-negative MSM completed a cross-sectional survey. Participants provided demographic information, and completed measures of HIV knowledge, perceived HIV risk, engagement in sexual risk behaviour, acquisition of a sexually transmitted infection (STI) in the last 12 months, frequency of HIV testing and PrEP acceptability...
August 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30160365/peripheral-artery-disease-in-hiv-infected-older-adults-on-antiretroviral-treatment-in-thailand
#15
L Aurpibul, P Sugandhavesa, K Srithanaviboonchai, W Sitthi, A Tangmunkongvorakul, C Chariyalertsak, K Rerkasem
OBJECTIVES: HIV infection has become a chronic disease requiring long-term treatment. Premature cardiovascular disease resulting from atherosclerosis in the HIV-infected population has been observed. We assessed the prevalence of peripheral artery disease (PAD), a common consequence of atherosclerosis, in HIV-infected patients aged ≥ 50 years receiving antiretroviral treatment (ART). METHODS: This cross-sectional study was conducted in 12 community hospitals in Chiang Mai, Thailand...
August 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30160349/hiv-infection-is-independently-associated-with-a-higher-concentration-of-alpha-1-antitrypsin
#16
R F Thudium, J Lundgren, T Benfield, B G Nordestgaard, Á H Borges, J Gerstoft, S D Nielsen, A Ronit
OBJECTIVES: Alpha-1 antitrypsin (AAT) deficiency is associated with an increased risk of chronic obstructive pulmonary disease and has been related to CD4 T-cell count decline in people living with HIV (PLWH). We determined whether HIV status is associated with AAT concentrations and assessed associations between AAT concentration, pulmonary function and immunological status. METHODS: Alpha-1 antitrypsin was measured and spirometry performed in 1011 PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and in 11 962 age- and sex-matched uninfected controls...
August 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30160347/longitudinal-evaluation-of-markers-of-inflammation-in-hiv-positive-and-hiv-negative-rwandan-women
#17
E M Kiefer, D R Hoover, Q Shi, J C Dusingize, J D Sinayobye, K Anastos
OBJECTIVES: African women are disproportionately affected by HIV infection and may experience non-AIDS-related complications associated with inflammation. High-sensitivity C-reactive protein (hsCRP), d-dimer and transthyretin have been examined as inflammatory markers elsewhere, but it is unclear how they change over time in HIV-negative or HIV-positive African women with or without antiretroviral therapy (ART) initiation. METHODS: We examined hsCRP, d-dimer and transthyretin levels at baseline and at follow-up of ≥2 years in 185 HIV-negative and 510 HIV-positive Rwandan women who were ART naïve at study entry...
August 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30160344/diagnostic-performance-of-clinical-characteristics-to-detect-airflow-limitation-in-people-living-with-hiv-and-in-uninfected-controls
#18
A Ronit, T Benfield, A Mocroft, J Gerstoft, B G Nordestgaard, J Vestbo, S D Nielsen
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is underdiagnosed in the general population and possibly also in people living with HIV (PLWH). We evaluated the diagnostic performance of symptoms and risk factors for assessment of airflow limitation in PLWH and in uninfected controls. METHODS: Spirometry was performed in the Copenhagen Comorbidity in HIV Infection (COCOMO) study and Copenhagen General Population Study (CGPS), and airflow limitation was defined by forced expiratory volume in 1 s/forced vital capacity < lower limit of normal...
August 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30160342/central-obesity-and-nonalcoholic-fatty-liver-disease-in-people-living-with-hiv-a-case-for-targeted-screening
#19
LETTER
C Dewar, Q M Anstee, D A Price, Bai Payne
No abstract text is available yet for this article.
August 30, 2018: HIV Medicine
https://www.readbyqxmd.com/read/30338931/a-note-of-thanks-to-referees-for-volume-19-2018
#20
(no author information available yet)
No abstract text is available yet for this article.
November 2018: HIV Medicine
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