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HIV Medicine

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https://www.readbyqxmd.com/read/28444867/urine-assay-for-tenofovir-to-monitor-adherence-in-real-time-to-tenofovir-disoproxil-fumarate-emtricitabine-as-pre-exposure-prophylaxis
#1
H C Koenig, K Mounzer, G W Daughtridge, C E Sloan, L Lalley-Chareczko, G S Moorthy, S C Conyngham, A F Zuppa, L J Montaner, P Tebas
OBJECTIVES: Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is approved for pre-exposure prophylaxis (PrEP) against HIV infection. Adherence is critical for the success of PrEP, but current adherence measurements are inadequate for real-time adherence monitoring. We developed and validated a urine assay to measure tenofovir (TFV) to objectively monitor adherence to PrEP. METHODS: We developed a urine assay using high-performance liquid chromatography coupled to tandem mass spectrometry with high sensitivity/specificity for TFV that allowed us to determine TFV concentrations in log10 categories between 0 and 10 000 ng/mL...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444865/a-high-rate-of-hiv-1-acquisition-post-immigration-among-migrants-in-sweden-determined-by-a-cd4-t-cell-decline-trajectory-model
#2
J Brännström, A Sönnerborg, V Svedhem, U Neogi, G Marrone
OBJECTIVES: There is a lack of knowledge about the extent to which migrants become HIV-1 infected after arrival in European countries. The objective of this study was to assess the extent to which migrants to Sweden become HIV-1 infected post immigration using a CD4 T-cell decline trajectory model. METHODS: All migrants (n = 2268) who were ≥ 15 years old, were diagnosed with HIV-1 infection in the period 1983-2013, had a known year of arrival in Sweden, did not have primary HIV infection and were not infected via mother-to-child transmission were included in the study...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444829/disparities-in-hiv-1-transmitted-drug-resistance-detected-by-ultradeep-sequencing-between-men-who-have-sex-with-men-and-heterosexual-populations
#3
E Todesco, C Charpentier, M Bertine, M Wirden, A Storto, N Desire, M Grude, T Nguyen, S Sayon, Y Yazdanpanah, C Katlama, D Descamps, V Calvez, A G Marcelin
OBJECTIVES: Transmitted drug resistance (TDR) can impair the response to first-line antiretroviral therapy. In treatment-naïve patients chronically infected with HIV type 1 (HIV-1), it was previously shown through Sanger sequencing that TDR was more common in men who have sex with men (MSM) than in other transmission risk groups. We aimed to compare two HIV-1 transmission groups in terms of the presence of TDR mutations. METHODS: We investigated, through Sanger sequencing and ultradeep sequencing (UDS), the presence of resistance mutations, both in majority (> 20%) and in minority (1-20%) proportions, in 70 treatment-naïve MSM and 70 treatment-naïve heterosexual patients who recently screened positive for HIV-1...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444818/reduced-community-viral-load-does-not-coincide-with-a-reduction-in-the-rate-of-new-hiv-diagnoses-and-recent-infections-data-from-a-region-of-southern-italy
#4
L Monno, A Saracino, L Scudeller, C Santoro, G Brindicci, G Punzi, A Lagioia, S Lo Caputo, G Angarano
OBJECTIVES: We assessed whether changes in community viral load (CVL) over time were associated with the rate of new HIV diagnoses (NDs). METHODS: HIV-1-positive individuals referred to our institute and permanently residing in our province were considered for inclusion in the study. A total of 861 HIV-infected adults with at least one HIV RNA measurement (12 530 measurements in total) between 2008 and 2014 were included. Viraemia copy-years were calculated from all HIV RNA values for each patient using the trapezoidal rule; multiple CVL indicators were considered...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444816/efficacy-and-safety-of-dolutegravir-and-rilpivirine-dual-therapy-as-a-simplification-strategy-a-cohort-study
#5
LETTER
P Gantner, L Cuzin, C Allavena, A Cabie, P Pugliese, M-A Valantin, F Bani-Sadr, V Joly, T Ferry, I Poizot-Martin, R Garraffo, G Peytavin, S Fafi-Kremer, D Rey
No abstract text is available yet for this article.
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444809/retrospective-review-of-routine-clinical-patient-experiences-with-dolutegravir-virological-suppression-immunological-recovery-and-adverse-events
#6
LETTER
O Negedu, S-H Kim, R Weston, N Naous, N Mackie, S Fidler
No abstract text is available yet for this article.
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28440036/a-tale-of-two-countries-all-cause-mortality-among-people-living-with-hiv-and-receiving-combination-antiretroviral-therapy-in-the-uk-and-canada
#7
S Patterson, S Jose, H Samji, A Cescon, E Ding, J Zhu, J Anderson, A N Burchell, C Cooper, T Hill, M Hull, M B Klein, M Loutfy, F Martin, N Machouf, Jsg Montaner, M Nelson, J Raboud, S B Rourke, C Tsoukas, R S Hogg, C Sabin
OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged ≥ 18 years, had initiated antiretroviral therapy (ART) for the first time between 2000 and 2012 and who had acquired HIV through sexual transmission were included in the analysis. Cox regression was used to investigate the difference in mortality risk between the two cohort collaborations, accounting for loss to follow-up as a competing risk...
April 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28378387/mining-for-pairs-shared-clinic-visit-dates-identify-steady-hiv-positive-partnerships
#8
A Marzel, M Shilaih, T Turk, N K Campbell, W-L Yang, J Böni, S Yerly, T Klimkait, V Aubert, H Furrer, A Calmy, M Battegay, M Cavassini, E Bernasconi, P Schmid, K J Metzner, H F Günthard, R D Kouyos
OBJECTIVES: Here we examined the hypothesis that some stable HIV-infected partnerships can be found in cohort studies, as the patients frequently attend the clinic visits together. METHODS: Using mathematical approximations and shuffling to derive the probabilities of sharing a given number of visits by chance, we identified and validated couples that may represent either transmission pairs or serosorting couples in a stable relationship. RESULTS: We analysed 434 432 visits for 16 139 Swiss HIV Cohort Study patients from 1990 to 2014...
April 4, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28332270/changes-in-elevated-cholesterol-in-the-era-of-tenofovir-in-south-africa-risk-factors-clinical-management-and-outcomes
#9
L Jamieson, D Evans, A T Brennan, F Moyo, D Spencer, K Mahomed, M Maskew, L Long, S Rosen, M P Fox
OBJECTIVES: Antiretroviral therapy (ART) has been associated with unfavourable lipid profile changes and increased risk of cardiovascular disease (CVD). With a growing population on ART in South Africa, there has been concern about the increase in noncommunicable diseases such as CVD. We determined risk factors associated with increased total cholesterol (TC) in a large cohort on ART and describe the clinical management thereof. METHODS: We conducted an observational cohort study of ART-naïve adults initiating standard first-line ART in a large urban clinic in Johannesburg, South Africa...
March 23, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28317290/the-effect-of-engagement-in-an-hiv-aids-integrated-health-programme-on-plasma-hiv-1-rna-suppression-among-hiv-positive-people-who-use-illicit-drugs-a-marginal-structural-modelling-analysis
#10
L Ti, H Dong, T Kerr, R B Turje, S Parashar, J E Min, J Montaner, E Wood, M-J Milloy
OBJECTIVES: HIV treatment-as-prevention campaigns emphasize early diagnosis and immediate access to care and antiretroviral therapy for HIV-positive individuals in order to increase levels of plasma HIV RNA viral load (VL) suppression. However, the possible role of harm reduction-based programmes in this objective has not yet been well evaluated. The objective of the study was to examine the relationship between being a client of the Dr. Peter Centre (DPC; an HIV/AIDS-focused adult integrated health programme) and VL suppression among highly active antiretroviral therapy (HAART)-exposed HIV-positive people who use illicit drugs (PWUD) in Vancouver, Canada...
March 19, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28296019/health-care-provider-communication-training-in-rural-tanzania-empowers-hiv-infected-patients-on-antiretroviral-therapy-to-discuss-adherence-problems
#11
S Erb, E Letang, T R Glass, A Natamatungiro, D Mnzava, H Mapesi, M Haschke, U Duthaler, B Berger, L Muri, J Bader, C Marzolini, L Elzi, T Klimkait, W Langewitz, M Battegay
OBJECTIVES: Self-reported adherence assessment in HIV-infected patients on antiretroviral therapy (ART) is challenging and may overestimate adherence. The aim of this study was to improve the ability of health care providers to elicit patients' reports of nonadherence using a "patient-centred" approach in a rural sub-Saharan African setting. METHODS: A prospective interventional cohort study of HIV-infected patients on ART for ≥ 6 months attending an HIV clinic in rural Tanzania was carried out...
March 13, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28294530/the-association-between-physical-activity-and-cognition-in-men-with-and-without-hiv-infection
#12
A K Monroe, L Zhang, L P Jacobson, M W Plankey, T T Brown, E N Miller, E Martin, J T Becker, A J Levine, A Ragin, N C Sacktor
OBJECTIVES: HIV-associated neurocognitive disorders are highly prevalent, and physical activity (PA) is a modifiable behaviour that may affect neurocognitive function. Our objective was to determine the association between PA and neurocognitive function and the effect of HIV on this association. METHODS: PA was assessed in the Multicenter AIDS Cohort Study with the International Physical Activity Questionnaire. A neuropsychological test battery assessed global impairment and domain-specific impairment (executive function, speed of processing, working memory, learning, memory, and motor function) every 2 years...
March 13, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28294498/respiratory-health-status-is-impaired-in-uk-hiv-positive-adults-with-virologically-suppressed-hiv-infection
#13
J Brown, J A McGowan, H Chouial, S Capocci, C Smith, D Ivens, M Johnson, L Sathia, R Shah, F C Lampe, A Rodger, M Lipman
OBJECTIVES: We sought to evaluate whether people living with HIV (PLWH) using effective antiretroviral therapy (ART) have worse respiratory health status than similar HIV-negative individuals. METHODS: We recruited 197 HIV-positive and 93 HIV-negative adults from HIV and sexual health clinics. They completed a questionnaire regarding risk factors for respiratory illness. Respiratory health status was assessed using the St George's Respiratory Questionnaire (SGRQ) and the Medical Research Council (MRC) breathlessness scale...
March 13, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28294492/high-prevalence-of-willingness-to-use-direct-acting-antiviral-based-regimens-for-hepatitis-c-virus-hcv-infection-among-hiv-hcv-coinfected-people-who-use-drugs
#14
M E Socías, L Ti, H Dong, J Shoveller, T Kerr, J Montaner, M-J Milloy
OBJECTIVES: Despite the high burden of hepatitis C virus (HCV)-related morbidity and mortality among HIV-positive people who use illicit drugs (PWUD), uptake of interferon-based treatments for HCV infection has been negligible among this group. Direct-acting antiviral (DAA) therapies offer an opportunity to expand treatment access among this population. The aim of this study was to explore willingness to use DAA-based regimens among HIV/HCV-coinfected PWUD in Vancouver, Canada. METHODS: Data were drawn from the AIDS Care Cohort to evaluate Exposure to Survival Services (ACCESS), a prospective cohort of HIV-positive PWUD...
March 13, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28247589/ethnicity-predicts-viral-rebound-after-travel-to-the-tropics-in-hiv-infected-travelers-to-the-tropics-in-the-swiss-hiv-cohort-study
#15
H M Gebreselassie, D Kraus, C A Fux, S Haubitz, A Scherrer, C Hatz, O Veit, M Stoeckle, J Fehr, S de Lucia, M Cavassini, E Bernasconi, P Schmid, H Furrer, C Staehelin
OBJECTIVES: The number of HIV-infected individuals from developed countries travelling to tropical and subtropical areas has increased as a result of the clinical and survival benefits of combination antiretroviral therapy. The aim of our study was to describe the traveler population in the SHCS and to determine the frequency of viral rebound in virologically suppressed individuals after a travel episode to the tropics compared to non-travelers. METHODS: Swiss HIV Cohort Study participants with at least one follow-up visit between 1 January 1989 and 28 February 2015 were eligible for inclusion in the study...
March 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28247479/does-efavirenz-replacement-improve-neurological-function-in-treated-hiv-infection
#16
B Payne, T J Chadwick, A Blamire, K N Anderson, J Parikh, J Qian, A M Hynes, J Wilkinson, D A Price
OBJECTIVES: The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy is a modifier of neurocognitive and neurometabolic function in the setting of suppressive highly active antiretroviral therapy. METHODS: We performed an open-label phase IV controlled trial. Adult subjects who were stable on suppressive EFV therapy for at least 6 months were switched to ritonavir-boosted lopinavir (LPV/r) with no change in the nucleoside reverse transcriptase inhibitor (NRTI) backbone...
March 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28230318/liver-related-mortality-and-hospitalizations-attributable-to-chronic-hepatitis-c-virus-coinfection-in-persons-living-with-hiv
#17
A Mena, H Meijide, I Rodríguez-Osorio, A Castro, E Poveda
OBJECTIVES: The aim of this study was to compare liver-related mortality and liver-related hospitalizations for persons living with HIV (PLWH) with and without hepatitis C virus (HCV) exposure, and to estimate the fraction of liver disease attributable to chronic HCV coinfection. METHODS: An ambispective cohort study followed PLWH between 1993 and 2014. PLWH were classified into three groups: those who were HIV-monoinfected, those who cleared HCV spontaneously and those with chronic HCV coinfection...
February 23, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28230311/prevalence-of-and-factors-associated-with-unprotected-anal-intercourse-with-regular-and-nonregular-male-sexual-partners-among-newly-diagnosed-hiv-positive-men-who-have-sex-with-men-in-china
#18
Z Wang, X Wu, Jtf Lau, Pkh Mo, Wws Mak, X Wang, X Yang, D Gross, H Jiang
OBJECTIVES: This study investigated the prevalence of, and multi-dimensional factors associated with, unprotected anal intercourse (UAI) with regular male sexual partners ('regular partners') and nonregular male sexual partners ('nonregular partners') among newly diagnosed HIV-positive men who have sex with men (MSM) in Chengdu, China. METHODS: A total of 225 newly diagnosed HIV-positive MSM were interviewed using a combined interviewer-computer-assisted method in Chengdu, China...
February 23, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28224755/the-impact-of-changes-in-hiv-management-guidelines-on-time-to-treatment-initiation-in-australia
#19
LETTER
R Puhr, K Petoumenos, D Youds, M G Law, D J Templeton
No abstract text is available yet for this article.
February 22, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28218480/human-leucocyte-antigen-hla-dqb1-03-02-and-hla-a-02-01-have-opposite-patterns-in-their-effects-on-susceptibility-to-hiv-infection
#20
N Rallón, C Restrepo, J L Vicario, J Del Romero, C Rodríguez, J García-Samaniego, M García, A Cabello, M Górgolas, J M Benito
OBJECTIVES: The objective of this study was to seek correlates of immune protection in HIV infection. We sought to elucidate the association between the presence of human leucocyte antigen (HLA) alleles, as well as killer immunoglobulin receptor (KIR) genotypes, and the susceptibility to HIV infection in a Spanish cohort of HIV-exposed seronegative (HESN) individuals. METHODS: A total of 152 individuals were evaluated: 29 HESN individuals in stable heterosexual relationships with an HIV-infected partner admitting high-risk sexual intercourse for at least 12 months prior to inclusion in the study, 61 HIV-infected patients and 62 healthy controls...
February 20, 2017: HIV Medicine
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