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HIV Medicine

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https://www.readbyqxmd.com/read/28205375/response-to-glinka-et-al-timing-matters-influenza-vaccination-to-hiv-infected-patients
#1
LETTER
C Williams
No abstract text is available yet for this article.
February 16, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28150466/who-will-be-lost-identifying-patients-at-risk-of-loss-to-follow-up-in-malawi-the-dream-program-experience
#2
S Mancinelli, K Nielsen-Saines, P Germano, G Guidotti, E Buonomo, P Scarcella, R Lunghi, H Sangare, S Orlando, G Liotta, M C Marazzi, L Palombi
OBJECTIVES: Retention of subjects in HIV treatment programmes is crucial for the success of treatment. We evaluated retention/loss to follow-up (LTFU) in subjects receiving established care in Malawi. METHODS: Data for HIV-positive patients registered in Drug Resource Enhancement Against AIDS and Malnutrition centres in Malawi prior to 2014 were reviewed. Visits entailing HIV testing/counselling, laboratory evaluations, nutritional evaluation/supplementation, community support, peer education, and antiretroviral (ART) monitoring/pharmacy were noted...
February 2, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28145050/cytochrome-2b6-polymorphism-and-efavirenz-induced-central-nervous-system-symptoms-a-substudy-of-the-anrs-alize-trial
#3
S Gallien, V Journot, M-A Loriot, H Sauvageon, P Morlat, J Reynes, V Reliquet, G Chêne, J-M Molina
OBJECTIVES: Single nucleotide polymorphisms in the cytochrome P450 (CYP) 2B6 gene have been associated with high interindividual variation in efavirenz pharmacokinetics. However, clinical data on the relationship of CYP2B6 polymorphisms with the occurrence of efavirenz-induced central nervous system (CNS) symptoms are limited. METHODS: We analysed four polymorphisms in the CYP2B6 (516 G>T), CYP3A5 (6986 A>G) and ATP-binding cassette, sub-family B, member 1 (ABCB1) (2677 G>T/A and 3435 C>T) genes in HIV-infected adults virologically suppressed on a protease inhibitor-based regimen who switched to a regimen containing emtricitabine, didanosine and efavirenz in the setting of the ANRS ALIZE trial...
February 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28127854/smaller-needles-lower-risks-occupational-hiv-risk-for-healthcare-professionals
#4
LETTER
J C Serna-Ojeda, A Navas, E O Graue-Hernandez
No abstract text is available yet for this article.
January 27, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28127837/hiv-incidence-in-an-open-national-cohort-of-men-who-have-sex-with-men-attending-sexually-transmitted-infection-clinics-in-england
#5
S Desai, A Nardone, G Hughes, V Delpech, F Burns, G Hart, O N Gill
OBJECTIVES: The aim of the study was to determine HIV incidence among men who have sex with men (MSM) who repeat test for HIV at sexually transmitted infection (STI) clinics in England, and identify associated factors. METHODS: Annual HIV incidence and 95% confidence interval (CI) were calculated for a national cohort of MSM who tested HIV negative at any STI clinic in England in 2012 and had a follow-up test within 1 year using routinely collected data. Cox regression analyses were performed to identify predictors of HIV acquisition and population attributable risk for HIV infection was calculated for predictors...
January 27, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28117545/recreational-drug-use-and-chemsex-among-hiv-infected-in-patients-a-unique-screening-opportunity
#6
E R Elliot, S Singh, S Tyebally, K Gedela, M Nelson
OBJECTIVES: While a high rate of recreational drug use (RDU) has been documented among HIV-infected out-patients, particularly in men who have sex with men (MSM), there is a distinct lack of data for HIV-infected in-patients. Hospital admission offers a unique opportunity to engage drug users. We aimed to establish and characterize RDU among new admissions to a large dedicated London HIV in-patient unit and compare it to RDU among general medical admissions to inform clinical pathways...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28117544/specialist-care-of-older-adults-with-hiv-infection-in-the-uk-a-service-evaluation
#7
F V Cresswell, T Levett
OBJECTIVES: There is a clear trajectory towards cohort ageing in the UK. HIV infection is associated with an increased prevalence of traditionally age-related comorbidities and geriatric syndromes. Some HIV services have been proactive in innovating models that cater for adapting needs. We aimed to describe how widespread this practice is and what form such services take. METHODS: We conducted an evaluation of the perceived need for and current provision of specialist ageing services, and the need for formal guidance on monitoring or treatment of older adults with HIV infection...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28117527/hiv-continuum-of-care-in-europe-and-central-asia
#8
R S Drew, B Rice, K Rüütel, V Delpech, K A Attawell, D K Hales, C Velasco, A J Amato-Gauci, A Pharris, L Tavoschi, T Noori
OBJECTIVES: The European Centre for Disease Prevention and Control (ECDC) supports countries to monitor progress in their response to the HIV epidemic. In line with these monitoring responsibilities, we assess how, and to what extent, the continuum of care is being measured across countries. METHODS: The ECDC sent out questionnaires to 55 countries in Europe and Central Asia in 2014. Nominated country representatives were questioned on how they defined and measured six elements of the continuum...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28116857/the-management-of-comorbidities-in-older-people-living-with-hiv-in-england-a-cross-sectional-survey
#9
LETTER
E Youssef, V Cooper, E Nixon, J H Vera, M Fisher, J Wright
No abstract text is available yet for this article.
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28116848/plasma-trough-concentrations-of-darunavir-ritonavir-and-raltegravir-in-older-patients-with-hiv-1-infection
#10
L Calza, V Colangeli, E Magistrelli, L Bussini, M Conti, E Ramazzotti, R Mancini, P Viale
OBJECTIVES: The aim of the study was to assess plasma concentrations of darunavir/ritonavir and raltegravir in older patients compared with younger patients with HIV-1 infection. METHODS: In this observational, open-label study, adult HIV-infected out-patients aged ≤ 40 years (younger patients) or ≥ 60 years (older patients) and treated with tenofovir/emtricitabine plus darunavir/ritonavir (800/100 mg daily) or raltegravir (400 mg twice daily) were asked to participate...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28116842/fat-mass-and-obesity-associated-gene-variations-are-related-to-fatty-liver-disease-in-hiv-infected-patients
#11
R Núñez-Torres, J Macías, A Rivero-Juarez, K Neukam, D Merino, F Téllez, N Merchante, J Gómez-Mateos, A Rivero, J A Pineda, L M Real
OBJECTIVES: Fatty liver disease (FLD) is frequently observed in HIV-infected patients. Obesity and type 2 diabetes mellitus (T2DM) are strongly associated with FLD. Because genetic variants within the fat mass and obesity-associated (FTO) gene have been associated with both pathologies, our aim was to evaluate the association of single nucleotide polymorphisms (SNPs) within the FTO, previously related to obesity or T2DM, with FLD in HIV-infected patients. METHODS: FLD was defined as a value of the controlled attenuation parameter (CAP) ≥ 238 dB/m, obtained by transient elastography...
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28116796/now-is-the-time-to-study-the-timing-of-influenza-vaccine
#12
LETTER
E R Glinka, D M Smith, S T Johns
No abstract text is available yet for this article.
January 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28070923/the-cascade-of-hiv-care-among-refugees-and-nationals-in-nakivale-refugee-settlement-in-uganda
#13
K N O'Laughlin, J Kasozi, D J Rabideau, R A Parker, E Mulogo, Z M Faustin, K E Greenwald, S Doraiswamy, R P Walensky, I V Bassett
OBJECTIVES: Refugees living in Uganda come from HIV-endemic countries, and many remain in refugee settlements for over a decade. Our objective was to evaluate the HIV care cascade in Nakivale Refugee Settlement and to assess correlates of linkage to care. METHODS: We prospectively enrolled individuals accessing clinic-based HIV testing in Nakivale Refugee Settlement from March 2013 to July 2014. Newly HIV-diagnosed clients were followed for 3 months post-diagnosis...
January 10, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28035766/impact-of-immigration-on-hiv-mother-to-child-transmission-in-western-europe
#14
LETTER
A Soriano-Arandes, A Noguera-Julian, C Fortuny
No abstract text is available yet for this article.
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28035758/genotypic-tropism-testing-of-proviral-dna-to-guide-maraviroc-initiation-in-aviraemic-subjects-48-week-analysis-of-results-from-the-protest-study
#15
E Poveda, J Hernández-Quero, M J Pérez-Elías, M A Ribas, O J Martínez-Madrid, J Flores, J Navarro, F Gutiérrez, M García-Deltoro, A Imaz, A Ocampo, A Artero, F Blanco, E Bernal, J Pasquau, C Mínguez-Gallego, N Pérez, A Aiestaran, F García, R Paredes
OBJECTIVES: Maraviroc (MVC) is a suitable drug for aviraemic subjects on antiretroviral treatment (ART) developing toxicity. Its prescription requires prior tropism testing. It is unknown if proviral DNA genotypic tropism testing is reliable for guiding MVC initiation in aviraemic subjects, so this study was carried out to address this issue. METHODS: PROTEST was a phase 4, prospective, single-arm clinical trial carried out in 24 HIV care centres in Spain. MVC-naïve HIV-1-infected patients with HIV-1 RNA < 50 copies/mL on stable ART during the previous 6 months who required an ART change because of toxicity and who had R5 HIV, as determined by proviral DNA genotypic tropism testing, initiated MVC with two nucleoside reverse transcriptase inhibitors (NRTIs) and were followed for 48 weeks...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28035738/predictors-for-and-coverage-of-influenza-vaccination-among-hiv-positive-patients-a-cross-sectional-survey
#16
N Harrison, W Poeppl, H Herkner, K D Tillhof, K Grabmeier-Pfistershammer, A Rieger, C Forstner, H Burgmann, H Lagler
OBJECTIVES: Influenza vaccination is recommended for HIV-infected patients, but limited data about vaccination rates are available. The aim of this study was to evaluate the coverage of and predictors for influenza vaccination among HIV-positive patients. METHODS: All HIV-positive patients who visited the HIV out-patient department of the University Hospital of Vienna, Austria, between June and August 2015 were asked to participate in this survey by completing a questionnaire...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28004523/accuracy-of-self-report-of-hiv-viral-load-among-people-with-hiv-on-antiretroviral-treatment
#17
J Sewell, M Daskalopoulou, F Nakagawa, F C Lampe, S Edwards, N Perry, E Wilkins, R O'Connell, M Jones, S Collins, A Speakman, A N Phillips, A J Rodger
OBJECTIVES: The aim of the study was to assess, among people living with HIV, knowledge of their latest HIV viral load (VL) and CD4 count. METHODS: Agreement between self-report and clinic record was assessed among 2771 HIV-diagnosed individuals on antiretroviral treatment (ART) in the UK Antiretrovirals, Sexual Transmission Risk and Attitudes Study (2011-2012). A confidential self-completed questionnaire collected information on demographic, socioeconomic, HIV-related and health-related factors...
December 22, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000390/an-oral-formulation-of-efavirenz-loaded-lactoferrin-nanoparticles-with-improved-biodistribution-and-pharmacokinetic-profile
#18
P Kumar, Y S Lakshmi, A K Kondapi
OBJECTIVES: Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, is a drug that is frequently included in highly active antiretroviral therapy for treatment of HIV infection. Decreased bioavailability and increased toxicity limit its use. We report a formulation of efavirenz-loaded lactoferrin nanoparticles (lacto-EFV-nano) for oral delivery which exhibited significantly improved pharmacological properties coupled with reduced toxicity compared with its free form. METHODS: Lacto-EFV-nano was prepared using the Sol-oil protocol and characterized using various sources of characterization...
December 21, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000379/rate-correlates-and-outcomes-of-repeat-pregnancy-in-hiv-infected-women
#19
M Floridia, E Tamburrini, G Masuelli, P Martinelli, A Spinillo, G Liuzzi, A Vimercati, S Alberico, A Maccabruni, C Pinnetti, V Frisina, S Dalzero, M Ravizza
OBJECTIVES: The aim of the study was to assess the rate, determinants, and outcomes of repeat pregnancies in women with HIV infection. METHODS: Data from a national study of pregnant women with HIV infection were used. Main outcomes were preterm delivery, low birth weight, CD4 cell count and HIV plasma viral load. RESULTS: The rate of repeat pregnancy among 3007 women was 16.2%. Women with a repeat pregnancy were on average younger than those with a single pregnancy (median age 30 vs...
December 21, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28000358/a-feasibility-study-for-a-clinical-decision-support-system-prompting-hiv-testing
#20
D R Chadwick, C Hall, C Rae, Ml Rayment, M Branch, J Littlewood, A Sullivan
OBJECTIVES: Levels of undiagnosed HIV infection and late presentation remain high globally despite attempts to increase testing. The objective of this study was to evaluate a risk-based prototype application to prompt HIV testing when patients undergo routine blood tests. METHODS: Two computer physician order entry (CPOE) systems were modified using the application to prompt health care workers (HCWs) to add an HIV test when other tests selected suggested that the patient was at higher risk of HIV infection...
December 21, 2016: HIV Medicine
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