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HIV Medicine

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https://www.readbyqxmd.com/read/28719012/the-impact-of-immunoglobulin-in-acute-hiv-infection-on-the-hiv-reservoir-a-randomized-controlled-trial
#1
J Tiraboschi, S Ray, K Patel, A Teague, M Pace, P Phalora, N Robinson, E Hopkins, J Meyerowitz, Y Wang, J Cason, S Kaye, J Sanderson, P Klenerman, S Fidler, J Frater, J Fox
OBJECTIVES: Antiretroviral therapy (ART) during acute HIV infection (AHI) restricts the HIV reservoir, but additional interventions are necessary to induce a cure. Intravenous immunoglobulin (IVIG) is not HIV-specific but is safe and temporarily reduces the HIV reservoir in chronic HIV infection. We present a randomized controlled trial to investigate whether IVIG plus ART in AHI reduces the HIV reservoir and immune activation compared with ART alone. METHODS: Ten men with AHI (Fiebig II-IV) initiated ART (tenofovir, entricitabine, ritonavir boosted darunavir and raltegravir) at HIV-1 diagnosis and were randomized to ART alone or ART plus 5 days of IVIG, once virally suppressed (week 19)...
July 18, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28696029/insurance-status-and-mortality-among-patients-with-aids
#2
A W Jabs, D A Jabs, M L Van Natta, F J Palella, C L Meinert
OBJECTIVES: The aim of the study was to evaluate risk factors for mortality, including health care insurance status, among patients with AIDS in the era of modern combination antiretroviral therapy (cART). METHODS: This study was part of the prospective, multicentre, observational Longitudinal Study of the Ocular Complications of AIDS (LSOCA). Patients were classified as having private health care insurance, Medicare, Medicaid, or no insurance. Hazard ratios (HRs) for death were calculated using proportional hazards regression models and staggered entries, anchored to the AIDS diagnosis date...
July 11, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28675626/epidemiology-of-tuberculosis-and-hiv-coinfections-in-singapore-2000-2014
#3
K Nandar, L W Ang, J Tey, L James, K M Kyi Win, Cbe Chee, O T Ng, J L Cutter, Y T Wang
Cross-matching of records between Singapore's tuberculosis and HIV registries showed that 3.3% of individuals with tuberculosis (TB) were coinfected with HIV (2000-2014), the TB incidence among individuals with HIV infection was 1.65 per 100 person-years, and 53% of coinfections were diagnosed within 1 month of each other. The findings supported joint prevention programmes for early diagnosis and treatment.
July 4, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28671337/significant-improvement-in-triglyceride-levels-after-switching-from-ritonavir-to-cobicistat-in-suppressed-hiv-1-infected-subjects-with-dyslipidaemia
#4
P Echeverría, A Bonjoch, J Puig, A Ornella, B Clotet, E Negredo
OBJECTIVES: Cobicistat seems to have a low rate of adverse events compared with ritonavir. METHODS: This restrospective observational study to evaluated changes in lipid parameters and the percentage of subjects with dyslipidemia in virologically suppressed HIV-infected patients who were receiving a regimen containing darunavir/ritonavir and were then switched from ritonavir to cobicistat, carried out from December 2015 to May 2016, included 299 HIV-1-infected patients who were on stable antiretroviral treatment including darunavir/ritonavir (monotherapy, bitherapy or triple therapy for at least 6 months) and were then switched from ritonavir to cobicistat...
July 3, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28657199/interprep-internet-based-pre-exposure-prophylaxis-with-generic-tenofovir-disoproxil-fumarate-emtrictabine-in-london-analysis-of-pharmacokinetics-safety-and-outcomes
#5
X Wang, N Nwokolo, R Korologou-Linden, A Hill, G Whitlock, I Day-Weber, M O McClure, M Boffito
OBJECTIVES: The National Health Service in England (NHS England) does not provide pre-exposure prophylaxis (PrEP) against HIV, forcing people to purchase generic versions on the internet. However, there are concerns about the authenticity of medicines purchased online. We established an innovative service offering plasma tenofovir (TFV) and emcitrabine (FTC) therapeutic drug monitoring for people buying generic PrEP online, to ensure that drug concentrations in vivo were consistent with those of propriety brands and previously published data...
June 28, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28631883/importance-of-the-patient-physician-interaction-in-assessing-acceptability-of-hiv-cure-trials
#6
LETTER
C Protière, M Préau, P Carrieri, O Lambotte, B Spire, M Suzan-Monti
No abstract text is available yet for this article.
June 20, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28612490/hiv-testing-in-persons-diagnosed-with-hepatitis-b-and-c
#7
LETTER
G Ireland, D Ogaz, P Kirwan, S Mandal, V Delpech, N Connor, R Simmons
No abstract text is available yet for this article.
June 14, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28585361/prevalence-of-hiv-1-transmitted-drug-resistance-in-the-incarcerated-population
#8
J Sapozhnikov, J D Young, M Patel, T D Chiampas, P Vaughn, M E Badowski
OBJECTIVES: The aim of the study was to determine the prevalence of transmitted drug resistance (TDR)-associated mutations among treatment-naïve, incarcerated individuals with HIV-1 infection in the USA as well as the class TDR and antiretroviral (ARV) mutations present at baseline. METHODS: Patients over the age of 18 years were included in the study if they had been diagnosed with HIV infection, if their HIV infection was managed through telemedicine and if they were incarcerated in the State of Illinois Department of Corrections between 10 July 2010 and 29 April 2016...
June 6, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28556456/gender-violence-poverty-and-hiv-infection-risk-among-persons-engaged-in-the-sex-industry-cross-national-analysis-of-the-political-economy-of-sex-markets-in-30-european-and-central-asian-countries
#9
A Reeves, S Steele, D Stuckler, M McKee, A Amato-Gauci, J C Semenza
OBJECTIVES: Persons engaged in the sex industry are at greater risk of HIV and other sexually transmitted infections than the general population. One major factor is exposure to higher levels of risky sexual activity. Expanding condom use is a critical prevention strategy, but this requires negotiation with those buying sex, which takes place in the context of cultural and economic constraints. Impoverished individuals who fear violence are more likely to forego condoms. METHODS: Here we tested the hypotheses that poverty and fear of violence are two structural drivers of HIV infection risk in the sex industry...
May 28, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28544321/assessment-of-mode-of-delivery-and-predictors-of-emergency-caesarean-section-among-women-living-with-hiv-in-a-matched-pair-setting-with-women-from-the-general-population-in-denmark-2002-2014
#10
M Ørbaek, K Thorsteinsson, M Helleberg, E Moseholm, T L Katzenstein, M Storgaard, I S Johansen, G Pedersen, N Weis, A-M Lebech
OBJECTIVES: We aimed to assess mode of delivery and predictors of emergency caesarean section (EmCS) in women living with HIV (WLWH) in a matched-pair setting with women from the general population (WGP) in Denmark. Further, we analysed birth plan in WLWH. METHODS: All WLWH giving birth to live-born children from 2002 to 2014 were included in the study. Data were retrieved from medical records and national registries. WLWH were matched 1:5 by age, birth year, parity and ethnicity to WGP...
May 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28544123/assessing-the-need-for-a-pre-exposure-prophylaxis-programme-using-the-social-media-app-grindr%C3%A2
#11
B Hampel, K Kusejko, D L Braun, J Harrison-Quintana, R Kouyos, J Fehr
OBJECTIVES: HIV pre-exposure prophylaxis (PrEP) is not approved in Switzerland and therefore must be paid for by the users themselves. We conducted a survey to find out whether men who have sex with men (MSM) in Switzerland are already taking PrEP, or are considering using it, and whether it is being taken under medical supervision or not. METHODS: Grindr® is a geosocial networking app for MSM. Between 5 and 24 January 2017, users of the app who were located in Switzerland by a global positioning system (GPS) were asked to participate in a ten-question survey on PrEP use...
May 19, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28503915/dual-therapy-with-a-combination-of-unboosted-atazanavir-and-lamivudine-as-maintenance-treatment-in-virologically-suppressed-hiv-1-infected-patients
#12
LETTER
F Rigo, G Cucchetto, M Lanzafame, S Nicolè, E Lattuada, E Concia, S Vento
No abstract text is available yet for this article.
May 15, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28503912/high-burden-of-metabolic-comorbidities-in-a-citywide-cohort-of-hiv-outpatients-evolving-health-care-needs-of-people-aging-with-hiv-in-washington-dc
#13
M E Levy, A E Greenberg, R Hart, L Powers Happ, C Hadigan, A Castel
OBJECTIVES: With the increasing impact of cardiovascular disease among populations aging with HIV, contemporary prevalence estimates for predisposing metabolic comorbidities will be important for guiding the provision of relevant lifestyle and pharmacological interventions. We estimated the citywide prevalence of hypertension, type 2 diabetes, dyslipidaemia, and obesity; examined differences by demographic subgroups; and assessed clinical correlates. METHODS: Utilizing an electronic medical record (EMR) database from the DC Cohort study - a multicentre prospective cohort study of HIV-infected outpatients - we assessed the period prevalence of metabolic comorbidities between 2011 and 2015 using composite definitions that incorporated diagnoses, pharmacy records, and clinical/laboratory results...
May 15, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28503852/smoking-associated-morbidities-on-computed-tomography-lung-cancer-screens-in-hiv-infected-smokers
#14
LETTER
S Bommart, A Cournil, S Eymard-Duvernay, F Raffi, I Bouassida, V Le Moing, J Reynes, A Makinson
No abstract text is available yet for this article.
May 15, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444865/a-high-rate-of-hiv-1-acquisition-post-immigration-among-migrants-in-sweden-determined-by-a-cd4-t-cell-decline-trajectory-model
#15
J Brännström, A Sönnerborg, V Svedhem, U Neogi, G Marrone
OBJECTIVES: There is a lack of knowledge about the extent to which migrants become HIV-1 infected after arrival in European countries. The objective of this study was to assess the extent to which migrants to Sweden become HIV-1 infected post immigration using a CD4 T-cell decline trajectory model. METHODS: All migrants (n = 2268) who were ≥ 15 years old, were diagnosed with HIV-1 infection in the period 1983-2013, had a known year of arrival in Sweden, did not have primary HIV infection and were not infected via mother-to-child transmission were included in the study...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444829/disparities-in-hiv-1-transmitted-drug-resistance-detected-by-ultradeep-sequencing-between-men-who-have-sex-with-men-and-heterosexual-populations
#16
E Todesco, C Charpentier, M Bertine, M Wirden, A Storto, N Desire, M Grude, T Nguyen, S Sayon, Y Yazdanpanah, C Katlama, D Descamps, V Calvez, A G Marcelin
OBJECTIVES: Transmitted drug resistance (TDR) can impair the response to first-line antiretroviral therapy. In treatment-naïve patients chronically infected with HIV type 1 (HIV-1), it was previously shown through Sanger sequencing that TDR was more common in men who have sex with men (MSM) than in other transmission risk groups. We aimed to compare two HIV-1 transmission groups in terms of the presence of TDR mutations. METHODS: We investigated, through Sanger sequencing and ultradeep sequencing (UDS), the presence of resistance mutations, both in majority (> 20%) and in minority (1-20%) proportions, in 70 treatment-naïve MSM and 70 treatment-naïve heterosexual patients who recently screened positive for HIV-1...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444818/reduced-community-viral-load-does-not-coincide-with-a-reduction-in-the-rate-of-new-hiv-diagnoses-and-recent-infections-data-from-a-region-of-southern-italy
#17
L Monno, A Saracino, L Scudeller, C Santoro, G Brindicci, G Punzi, A Lagioia, S Lo Caputo, G Angarano
OBJECTIVES: We assessed whether changes in community viral load (CVL) over time were associated with the rate of new HIV diagnoses (NDs). METHODS: HIV-1-positive individuals referred to our institute and permanently residing in our province were considered for inclusion in the study. A total of 861 HIV-infected adults with at least one HIV RNA measurement (12 530 measurements in total) between 2008 and 2014 were included. Viraemia copy-years were calculated from all HIV RNA values for each patient using the trapezoidal rule; multiple CVL indicators were considered...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444816/efficacy-and-safety-of-dolutegravir-and-rilpivirine-dual-therapy-as-a-simplification-strategy-a-cohort-study
#18
LETTER
P Gantner, L Cuzin, C Allavena, A Cabie, P Pugliese, M-A Valantin, F Bani-Sadr, V Joly, T Ferry, I Poizot-Martin, R Garraffo, G Peytavin, S Fafi-Kremer, D Rey
No abstract text is available yet for this article.
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28444809/retrospective-review-of-routine-clinical-patient-experiences-with-dolutegravir-virological-suppression-immunological-recovery-and-adverse-events
#19
LETTER
O Negedu, S-H Kim, R Weston, N Naous, N Mackie, S Fidler
No abstract text is available yet for this article.
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28440036/a-tale-of-two-countries-all-cause-mortality-among-people-living-with-hiv-and-receiving-combination-antiretroviral-therapy-in-the-uk-and-canada
#20
S Patterson, S Jose, H Samji, A Cescon, E Ding, J Zhu, J Anderson, A N Burchell, C Cooper, T Hill, M Hull, M B Klein, M Loutfy, F Martin, N Machouf, Jsg Montaner, M Nelson, J Raboud, S B Rourke, C Tsoukas, R S Hogg, C Sabin
OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged ≥ 18 years, had initiated antiretroviral therapy (ART) for the first time between 2000 and 2012 and who had acquired HIV through sexual transmission were included in the analysis. Cox regression was used to investigate the difference in mortality risk between the two cohort collaborations, accounting for loss to follow-up as a competing risk...
April 24, 2017: HIV Medicine
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