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Histopathology

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https://www.readbyqxmd.com/read/28722802/pathology-imagebase-a-reference-image-database-for-standardization-of-pathology
#1
Lars Egevad, John Cheville, Andrew J Evans, Jonas Hörnblad, James G Kench, Glen Kristiansen, Katia R M Leite, Cristina Magi-Galluzzi, Chin-Chen Pan, Hemamali Samaratunga, John R Srigley, Lawrence True, Ming Zhou, Mark Clements, Brett Delahunt
AIMS: Despite efforts to standardize histopathology practice through the development of guidelines, the interpretation of morphology is still hampered by subjectivity. We here describe Pathology Imagebase, a novel mechanism for establishing an international standard for the interpretation of pathology specimens. METHODS AND RESULTS: The International Society of Urological Pathology (ISUP) established a reference image database through the input of experts in the field...
July 19, 2017: Histopathology
https://www.readbyqxmd.com/read/28722262/braf-p-v600e-specific-immunohistochemical-assessment-in-colorectal-cancer-endoscopy-biopsies-is-consistent-with-the-mutational-profiling
#2
LETTER
Francesca Galuppini, Gianmaria Pennelli, Fotios Loupakis, Cristiano Lanza, Luca Vianello, Diana Sacchi, Claudia Mescoli, Roberta Salmaso, Marco Agostini, Sara Lonardi, Fabio Farinati, Massimo Rugge, Matteo Fassan
The assessment of BRAF p.V600E mutational status has already become an essential part of the diagnostic routine in colorectal cancer (CRC). Indeed, on one side, the BRAF mutational status is regarded as being a key molecular marker to definitely decide the most proper therapeutic options in a selected cohort of patients. On the other, it is used to exclude a suspicious of Lynch Syndrome in case of MLH1 absence in deficient mismatch repair (dMMR) tumors [1]. This article is protected by copyright. All rights reserved...
July 19, 2017: Histopathology
https://www.readbyqxmd.com/read/28722218/copper-copper-binding-protein-and-cytokeratin-7-in-biliary-disorders
#3
LETTER
Alberto Quaglia, Prithi Bathal
Accumulation of copper and copper binding protein in periportal hepatocytes is generally considered to be an indicator of chronic cholestasis and a sign of chronic biliary pathology, particularly at an early stage when bilirubinostasis is lacking (1). Rhodanine and Orcein or Victoria blue staining methods detect copper and copper binding protein respectively. Cytokeratin 7 expression by periportal hepatocytes or hepatocyte-like cells (intermediate hepatobiliary cells) (2) is also considered an early marker of chronic cholestasis (1)...
July 19, 2017: Histopathology
https://www.readbyqxmd.com/read/28718917/proliferation-of-elastic-fibers-in-idiopathic-pulmonary-fibrosis-a-whole-slide-image-analysis-and-comparison-with-pleuroparenchymal-fibroelastosis
#4
Yoshiaki Kinoshita, Kentaro Watanabe, Hiroshi Ishii, Hisako Kushima, Masaki Fujita, Kazuki Nabeshima
BACKGROUND: We occasionally encounter patients with idiopathic pulmonary fibrosis (IPF) who have similar imaging patterns to pleuroparenchymal fibroelastosis (PPFE) in the upper lung fields but are not diagnosed as PPFE clinically. The clinicopathological features and intrapulmonary distribution of elastic fibers and collagen fibers in these patients have not been fully elucidated. METHODS: We retrospectively reviewed the medical records of patients with a clinical diagnosis of IPF and selected the consecutive patients who received autopsy or pneumonectomy for lung transplantation...
July 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28718911/clear-cell-renal-cell-carcinoma-validation-of-who-isup-grading
#5
Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, John R Srigley, Geoffrey Coughlin, Nigel Dunglinson, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, John Yaxley, Hemamali Samaratunga
AIM: In 2012, the International Society of Urological Pathology (ISUP) introduced a novel grading system for clear cell and papillary renal cell carcinoma (RCC) based upon increasing nucleolar prominence in grades 1 to 3, with the presence of extreme nuclear pleomorphism and/or tumour giant cells and/or sarcomatoid and/or rhabdoid differentiation as criteria for grade 4. This system is now incorporated in the latest World Health Organization renal tumour classification, being designated WHO/ISUP grading...
July 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28710830/prognostic-significance-of-a-comprehensive-histologic-evaluation-of-reticulin-fibrosis-collagen-deposition-and-osteosclerosis-in-primary-myelofibrosis-patients
#6
Umberto Gianelli, Stefano Fiori, Daniele Cattaneo, Anna Bossi, Ivan Cortinovis, Arturo Bonometti, Giulia Ercoli, Cristina Bucelli, Nicola Orofino, Gaetano Bulfamante, Alessandra Iurlo
AIMS: to evaluate whether a comprehensive histological evaluation of reticulin fibrosis, collagen deposition and osteosclerosis in bone marrow trephine biopsies (BMBs) of primary myelofibrosis (PMF) patients may have prognostic implications. METHODS: reticulin fibrosis, collagen deposition and osteosclerosis were graded from 0 to 3 in a series of 122 base-line BMBs. Then, we assigned to each case a comprehensive score (RCO score, ranging from 0 to 9) that allowed us to distinguish two groups of patients, with low-grade (RCO score 0-4) and high-grade (RCO score 5-9) stromal changes...
July 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28710822/prevalence-and-significance-of-hmga2-expression-in-esophageal-adenocarcinoma
#7
Jeffrey K Mito, Agoston T Agoston, Paola Dal Cin, Amitabh Srivastava
AIMS: Esophageal adenocarcinoma (EAC) tumorigenesis has been primarily linked to loss-of-function mutations in tumor suppressor genes. Knowledge of specific oncogenes that drive tumor progression, and their relationship to outcomes, is limited. High Mobility Group AT-Hook 2 (HMGA2) has been reported to be amplified in a subset of EACs, but the clinicopathologic and prognostic implications of HMGA2 expression in EAC is unknown. METHODS AND RESULTS: We performed HMGA2 immunohistochemistry and fluorescence in-situ hybridization (FISH) in EAC to determine its clinicopathologic and prognostic significance...
July 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28703285/cervical-mesonephric-hyperplasia-lacks-kras-nras-mutations
#8
LETTER
Jelena Mirkovic, Kenneth J Schoolmeester, Frank Campbell, Alexander Miron, Marisa R Nucci, Brooke E Howitt
Mesonephric carcinoma, a rare malignant tumor thought to be derived from mesonephric remnants and/or hyperplasia, has recently been characterized by recurrent KRAS/NRAS mutations (1). The molecular features of mesonephric hyperplasia and whether it truly represents a precursor lesion to mesonephric carcinoma are unknown. This article is protected by copyright. All rights reserved.
July 13, 2017: Histopathology
https://www.readbyqxmd.com/read/28677299/tdt-expression-in-normal-and-neoplastic-sebaceous-cells
#9
Sofia-Eleni Tzorakoleftheraki, Alexandros Iliadis, Ioannis Kostopoulos, Triantafyllia Koletsa
AIMS: Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase expressed in immature, normal and neoplastic, lymphoid or hematopoietic cells and in neuroendocrine carcinomas, like Merkel cell carcinoma and small cell carcinoma. It has not yet been described in cells of epithelial origin. After observing TdT immunoreactivity in normal sebaceous glands we analyzed its spectrum of expression in cases of sebaceous cell hyperplasia and sebaceous cell neoplasms. METHODS & RESULTS: Twelve cases of sebaceous gland hyperplasia (SGH), and three cases of other benign lesions, namely, sebaceoma, sebaceous adenoma and sebaceous nevus, along with four archived cases of sebaceous cell carcinomas (SC) were collected and stained with TdT antibody...
July 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28677240/application-of-automated-image-analysis-reduces-the-workload-of-manual-screening-of-sentinel-lymph-node-biopsies-in-breast-cancer
#10
Henrik Holten-Rossing, Maj-Lis Møller Talman, Anne Marie Bak Jylling, Anne-Vibeke Laenkholm, Martin Kristensson, Ben Vainer
INTRODUCTION: Breast cancer is one of the most common cancer diseases in women with more than 1.67 million cases diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumor spreads and it is usually located in the ipsilateral axilla. In patients with no clinical signs of metastatic disease in the axilla, a SLN biopsy (SLNB) is performed. Assessment of metastases in the SLNB is done in a conventional microscope by manually observing a metastasis and measuring its size and/or counting the number of tumor cells...
July 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28675515/micrometastatic-gastric-glomus-tumor-confirmed-by-next-generation-sequencing
#11
LETTER
John Davis, Matthew Petterson, James Newell, Gregory Y Lauwers, Thomas Royce, Michael J Demeure
Glomus tumors are uncommon perivascular neoplasms.(1) Derived from the glomus bodies of the dermis involved in thermoregulation, glomus tumors are found most frequently in areas of the body rich in such glomus bodies, including the subungual areas of the digits and the distal extremities in general. Although they are most common in the superficial tissues, glomus tumors may occur in visceral organs, including the liver, lung, pancreas, and gastrointestinal and genitourinary tracts.(2) When glomus tumors do occur in the gastrointestinal tract, they are most often located in the stomach...
July 4, 2017: Histopathology
https://www.readbyqxmd.com/read/28670692/reply-to-low-grade-intraductal-carcinoma-of-the-prostate-an-idea-whose-time-has-not-yet-come-evidence-based-medicine-suggests-that-the-time-is-now
#12
LETTER
Rajal B Shah
In the above-referenced commentary,(1) Murali Varma raises two valid concerns regarding implications for communication from the message of our study(2) . First, introducing a term "Atypical Intraductal Proliferation (AIP)" or "low-grade intraductal carcinoma (IDC-P)" for which there are no well-defined morphological cut-offs or criteria and, second, for the risk of overtreatment. In this author's experience which is based on current(2) and previous studies,(3-6) AIPs represent significant lesions and must be distinguished from HGPIN...
July 3, 2017: Histopathology
https://www.readbyqxmd.com/read/28664668/human-papillomavirus-related-carcinoma-with-adenoid-cystic-like-features-a-series-of-5-cases-expanding-the-pathologic-spectrum
#13
Jen-Fan Hang, Min-Shu Hsieh, Wing-Yin Li, Jo-Yu Chen, Shih-Yao Lin, Shih-Hao Liu, Chin-Chen Pan, Ying-Ju Kuo
AIMS: Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a newly described entity of the sinonasal tract. In this study, we evaluated histomorphology, immunophenotype, and molecular testing to identify potentially helpful features in distinguishing it from classical adenoid cystic carcinoma (AdCC). METHODS AND RESULTS: We retrospectively collected 5 HPV-related carcinomas with adenoid cystic-like features and 14 AdCCs of the sinonasal tract...
June 30, 2017: Histopathology
https://www.readbyqxmd.com/read/28660626/hepatocellular-malignant-neoplasm-nos-a-clinicopathologic-study-of-11-cases-from-a-single-institution
#14
Shengmei Zhou, Rajkumar Venkatramani, Shveta Gupta, Kasper Wang, Larry Wang, Leo Mascarenhas
AIMS: The primary aim of this study is to characterize hepatocellular malignant neoplasm, NOS (HEMNOS), a new provisional entity describing a subset of paediatric hepatocellular tumours, which have histological features of neither typical hepatoblastoma (HB) nor hepatocellular carcinoma (HCC). METHODS AND RESULTS: The clinicopathological features of 11 patients with HEMNOS were analyzed retrospectively. The median age and serum alpha-fetoprotein level at diagnosis was 7 years and 182,000 ng/mL respectively...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28657118/clinicopathologic-findings-in-female-to-male-gender-affirming-breast-surgery
#15
Ellen G East, Katherine M Gast, William M Kuzon, Emily Roberts, Lili Zhao, Julie M Jorns
AIMS: Gender dysphoria is a diagnosis wherein an individual identifies as the opposite gender. Management of patients seeking female-to-male (FTM) transition includes hormonal therapy and surgical intervention, including mastectomy. We aim to characterize the immunohistologic findings in resection specimens from FTM patients. METHODS AND RESULTS: We reviewed 68 cases (67 patients, 1 with re-excision) of FTM breast tissue resection by collecting clinical data, reviewing breast imaging and pathology reports (gross fibrous density, specimen weight and number of cassettes submitted), and reviewing pathology slides (number of tissue pieces submitted, number of terminal duct lobule units [TDLUs], and presence of histologic findings)...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28657117/low-grade-intraductal-carcinoma-of-the-prostate-an-idea-whose-time-has-not-yet-come
#16
Murali Varma
Shah et al describe a prostatic intraductal proliferation morphologically intermediate between high-grade PIN (HGPIN) and intraductal carcinoma (IDCP) for which they use the term "atypical intraductal proliferation (AIP).(1) They compared the clinicopathological and immunohistochemical characteristics (ERG and PTEN expression) of AIP and IDCP in consecutive prostate biopsies and concluded based on this and previous findings(2) that AIP represents lower-grade morphological spectrum of IDCP associated with an intermediate risk of associated prostate cancer compared to HGPIN and IDCP...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28656712/uterine-tumour-resembling-ovarian-sex-cord-tumour-utrosct-first-report-of-a-large-series-with-follow-up
#17
Michelle Moore, W Glenn McCluggage
AIMS: Uterine tumour resembling ovarian sex cord tumour (UTROSCT) is an uncommon mesenchymal neoplasm of uncertain histogenesis. While it is considered a neoplasm of uncertain but low malignant potential, there is limited evidence for this since there are no large studies with follow-up. We aimed to determine the clinical behaviour of this uncommon neoplasm and investigate clinicopathological parameters which predict behaviour. METHODS AND RESULTS: From a series of 34 cases of UTROSCT, mainly from consultation practice, we obtained follow-up information which was obtained by contacting referring pathologists and clinicians...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28656700/chromosomal-abnormalities-of-high-grade-mucinous-tubular-and-spindle-cell-carcinoma-of-the-kidney
#18
Evita T Sadimin, Ying-Bei Chen, Lu Wang, Pedram Argani, Jonathan I Epstein
INTRODUCTION: Mucinous tubular and spindle cell carcinoma (MTSC) of the kidney is a distinct entity characterized by bland tightly packed elongated tubules and spindle cells with low nucleolar grade in a basophilic mucinous stroma. Several case studies have reported MTSC with high grade features and have brought into question whether they represented MTSC or a variant of papillary renal cell carcinoma. MATERIALS AND METHODS: We searched our pathology database and identified seven cases: six MTSC with high International Society of Urological Pathology (ISUP) nucleolar grade, and one MTSC with overall low nucleolar grade but extensive necrosis...
June 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28644569/gastrointestinal-stromal-tumors-of-the-esophagus-a-clinicopathologic-and-molecular-analysis-of-27-cases
#19
Guhyun Kang, Yuna Kang, Kyung-Hee Kim, Sang Yun Ha, Jung Yeon Kim, Young Mog Shim, Michael C Heinrich, Kyoung-Mee Kim, Christopher L Corless
AIMS: Gastrointestinal stromal tumors (GISTs) may arise anywhere in the gastrointestinal tract, but are rare in the esophagus. We describe the clinical, pathologic, and molecular characteristics of 27 primary esophageal GISTs, the largest series to date. METHODS AND RESULTS: DNA was extracted and exons 9, 11, 13 and 17 of KIT, exons 12, 14 and 18 of PDGFRA and exon 15 of BRAF were amplified and sequenced. Esophageal GISTs occurred in 14 men and 13 women between 22 and 80 years of age (mean, 56 years)...
June 23, 2017: Histopathology
https://www.readbyqxmd.com/read/28644513/benign-vascular-lesions-of-the-breast-diagnosed-by-core-needle-biopsy-do-not-require-excision
#20
Christopher Sebastiano, Lucas Gennaro, Edi Brogi, Elizabeth Morris, Zenica L Bowser, Cristina R Antonescu, Fresia Pareja, Sandra Brennan, Melissa P Murray
AIMS: Surgical excision of all benign vascular lesions of the breast identified by core needle biopsy has been recommended in the past to rule out a more serious lesion. In this study we investigated the clinical, radiologic, and pathologic findings in patients diagnosed with a benign vascular lesion at our institution to assess whether excision may be spared for lesions without atypia. METHODS AND RESULTS: We searched the electronic medical record for patients with a vascular lesion of the breast diagnosed between 2000 and 2015...
June 23, 2017: Histopathology
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