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Pedro Weslley Rosario
Recently, it was proposed that the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (noninvasive E-FVPTC) start to be called "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP).1 As the original cohort of 109 patients with NIFTP studied by the consensus conference included only tumors which were equal or more than 1 cm in size, the consensus diagnostic criteria of NIFTP did not explicitly address subcentimeter lesions.1,2 In fact, in a recent review published in this journal, Hung & Barletta recognize that there are a few published subcentimetre NIFTP in the literature...
May 23, 2018: Histopathology
Tadao Nakazawa, Tetsuo Kondo, Huy Gia Vunong, Toru Odate, Masataka Kawai, Ippei Tahara, Kazunari Kasai, Tomohiro Inoue, Naoki Oishi, Kunio Mochizuki, Koichi Ito, Ryohei Katoh
AIMS: CD10 is an endopeptidase that degrades variable bioactive peptides in extra-cellular matrix. In addition to the enzymatic degradation, it affects multiple intra-cellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. However, its presence is not fully determined in thyroid carcinomas, especially in anaplastic thyroid carcinoma (ATC). METHODS AND RESULTS: We examined CD10 by immunohistochemistry (IHC) in 152 thyroid lesions: 9 adenomatous goiters (AGs) and 143 tumors including 47 anaplastic carcinomas...
May 23, 2018: Histopathology
Noemi Rudini, Chiara Novello, Annarita Destro, Elena Riboldi, Matteo Donadon, Luca Viganò, Emanuela Morenghi, Massimo Roncalli, Luca Di Tommaso
BACKGROUND: Nodule in nodule hepatocellular carcinoma (N/N HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer more differentiated tumor, which can be rapidly taken over by the former so that N/N HCC is rarely detected. METHODS AND RESULTS: Ten resected N/N HCC in cirrhosis characterized, as outer lesions, by early (n.3) and G1 (n.7) HCC and, as inner lesions, by G1 (n.3) and G2 (n.7) HCC. The largest/smallest diameters of outer and inner nodules were, respectively, 20/6 and 16/4 mm...
May 23, 2018: Histopathology
Bharat Rekhi, Prachi Bapat, Parul Tripathi, Omshree Shetty, Ajay Puri
a solitary fibrous tumour (SFT) is a mesenchymal tumour of fibroblastic origin that invariably displays a prominent hemangiopericytoma (HPC)-like vasculature. Currently, hemangiopericytoma (HPC) of soft tissues is a disregarded entity and is rather considered as a growth pattern, more often seen in tumours such as synovial sarcomas, malignant peripheral nerve sheath tumours, myopericytomas and SFTs. In most SFTs, tumour cells are CD34 immunopositive.1-2 Lately, signal transducer and activator of transcription (STAT)6 has been identified as a highly sensitive and specific immunohistochemical (IHC) marker for diagnosing a SFT, and a surrogate for a specific fusion gene, NAB2-STAT6, characterizing most SFTs...
May 23, 2018: Histopathology
M Angeles Montero, Javier de Gracia, Mario Culebras, Jacqueline Mugnier, Antonio Álvarez, Cristina Berastegui, Cristian Ortiz-Villalón
INTRODUCTION: Lung transplant monitoring is usually assessed by forceps transbronchial biopsies. These types of biopsies show limited reliability and high degree of variability due to insufficient material and compression artefact, which lead to misinterpretation and eventually mistreatment of the transplanted patients. The following study was undertaken to assess the diagnostic yield, histological quality and safety of cryobiopsy in comparison with conventional forceps biopsy for sampling lung tissue in transplant recipients...
May 19, 2018: Histopathology
Fadi Brimo, Michelle R Downes, Tamara Jamaspishvili, David Berman, Guliz A Barkan, Daniel Athanazio, Schuharazad Abro, Kash Visram, Asli Yilmaz, Shraddha Solanki, Elan Hahn, Robert Siemens, Wassim Kassouf, Kiril Trpkov
We undertook a systematic evaluation of the prognostic value of numerous histologic factors in 165 radical cystectomies (RC) of patients with invasive urothelial carcinoma who underwent surgery after neoadjuvant chemotherapy (NAC). Tumor regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0+pN0) and 28% had no evidence of residual muscle invasive carcinoma (≤pT1+N0)...
May 18, 2018: Histopathology
Daniel S Strasser, Shanon Seger, Christian Bussmann, Gabin M Pierlot, Peter M A Groenen, Anna K Stalder, Alex Straumann
BACKGROUND AND AIMS: Eosinophilic esophagitis (EoE) is a chronic-inflammatory disease characterized clinically by symptoms of esophageal dysfunction and histopathologically by a prominent eosinophilic inflammation. Despite eosinophils having histologically a pre-dominant position, their role in the immunopathogenesis of the disease is still questionable. Several other inflammatory cells are involved and may play a critical role as well. The purpose of this study was to characterize the mast cell infiltration, and to correlate it with clinical state of EoE...
May 17, 2018: Histopathology
Won-Tak Choi, Kwun Wah Wen, Peter S Rabinovitch, Danning Huang, Aras N Mattis, Ryan M Gill
AIMS: Serrated lesions (SLs), including sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA), are important premalignant lesions for colorectal cancer (CRC). Although a small subset of SLs are known to harbor TP53 mutations and Wnt/β-catenin pathway activation, suggesting that they may develop dysplasia or CRC via a 'chromosomal instability (CIN)-like' pathway, it is unclear if aneuploidy (characteristic of conventional adenoma) ever develops in SLs and is associated with development of dysplasia or CRC, in this context...
May 17, 2018: Histopathology
Gulisa Turashvili, Rachel N Grisham, Sarah Chiang, Deborah F Delair, Kay J Park, Robert A Soslow, Rajmohan Murali
AIMS: The most common BRAF mutation in ovarian low-grade serous neoplasms (LGSNs) involves substitution of valine by glutamic acid at position 600 (V600E). Small studies have demonstrated high specificity of immunohistochemistry with mutation-specific monoclonal antibody VE1. We sought to investigate expression of VE1 protein in LGSNs and its correlation with BRAF mutation-associated histological features and BRAF mutation status. METHODS AND RESULTS: We reviewed pathology reports and available slides from ovarian serous borderline tumours (SBTs) and low-grade serous carcinomas (LGSCs) diagnosed between 2000-2012...
May 16, 2018: Histopathology
Astrid De Meulenaere, Tijl Vermassen, David Creytens, Sandrine Aspeslagh, Philippe Deron, Frederic Duprez, Sylvie Rottey, Jo Van Dorpe, Liesbeth Ferdinande
INTRODUCTION: A great deal of research is being conducted into PD-L1 immunohistochemistry (IHC) and tumor infiltrating lymphocytes (TILs) as predictive or prognostic biomarkers for immunotherapy, although several practical issues exist concerning their assessment. The aim of this research was therefore to assess the importance of choice of materials and methods in PD-L1 and TILs scoring in oropharyngeal squamous cell carcinoma (OSCC). METHODS AND RESULTS: IHC for PD-L1 (SP142 and 22C3 clone) and TILs subtyping was performed on formalin-fixed paraffin-embedded tissue slides (biopsy, resection and/or lymph nodes specimens) of 99 patients with OSCC...
May 16, 2018: Histopathology
Sanda Alexandrescu, Vera Paulson, Adrian Dubuc, Azra Ligon, Hart G Lidov
INTRODUCTION: The PHOX2B gene regulates neuronal maturation in the brain stem nuclei associated with cardiorespiratory function, and in the autonomic sympathetic and enteric nervous system. PHOX2B expression is a reliable immunomarker for peripheral neuroblastic tumors, however no systematic evaluation of CNS embryonal tumors was included in the studies. We encountered two cases in which the differential diagnosis included neuroblastoma and CNS embryonal tumor, and we hypothesized that PHOX2B immunostain would be helpful establishing the diagnosis...
May 14, 2018: Histopathology
Lianne Koens, Peter M van de Ven, Nathalie J Hijmering, Marie José Kersten, Arjan Diepstra, Martine Chamuleau, Daphne de Jong
CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. For reliable implementation in daily practice and meaningful selection of patients for clinical trials, information on technical variation and interobserver reproducibility of CD30 IHC staining is required. We conducted a 3-round reproducibility assessment of CD30 scoring for categorized frequency and intensity, including a technical validation, a "live polling" pre- and post-instruction scoring round, and a web-based round including individual scoring with additional IHC information to mimic daily diagnostic practice...
May 14, 2018: Histopathology
Nooshin K Dashti, Rebecca N Wehrs, Brittany C Thomas, Asha Nair, Jaime Davila, Jan C Buckner, Anthony P Martinez, William R Sukov, Kevin C Halling, Benjamin M Howe, Andrew L Folpe
AIMS: Rhabdomyosarcomas of bone are extremely rare, with fewer than 10 reported cases. A very rare subtype of spindle cell/sclerosing rhabdomyosarcoma harboring a FUS-TFCP2 fusion and involving both soft tissue and bone locations has very recently been reported. We report only the fourth case of this unusual, clinically aggressive rhabdomyosarcoma. MATERIAL AND RESULTS: A previously-well 72-year old male presented with a destructive lesion of the mandible. Morphological and immunohistochemical study of a needle biopsy and the subsequent resection showed a spindle cell rhabdomyosarcoma...
May 14, 2018: Histopathology
R Perret, M L Jullie, B Vergier, J M Coindre, F Le Loarer
Granular cell tumors (GCT) are frequent peripheral nerve sheath neoplasms with a wide anatomical distribution, mostly occurring in adults. Typically, tumor cells present an ample, intensely eosinophilic granular cytoplasm and express neural crest derived markers (S-100 and SOX10). In 1991, Leboit and colleagues1 described a cutaneous variant of GCT displaying otherwise similar histological features, lacking expression of neural markers and showing a polypoid configuration. This article is protected by copyright...
May 9, 2018: Histopathology
Sven Schneider, Lorenz Kadletz, Robert Wiebringhaus, Lukas Kenner, Edgar Selzer, Thorsten Füreder, Orsolya Rajky, Anna S Berghoff, Matthias Preusser, Gregor Heiduschka
AIMS: Expression profiles and clinical impact of programmed cell death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) expressing tumour infiltrating lymphocytes (TILs) in head and neck squamous cell carcinoma (HNSCC) are not fully elucidated. This study evaluates expression patterns in primary HNSCC and related lymph node metastasis and impact on patients' clinical outcome. METHODS AND RESULTS: Immunohistochemical staining patterns of PD-L1 and PD-1 were evaluated in 129 specimens of primary HNSCC and 77 lymph node metastases...
May 9, 2018: Histopathology
Authur Affleck, William B Lyman, W Carl Jacobs, Chad A Livasy, John B Martinie, David A Iannitti, Dionisios Vrochides
The hepatocyte paraffin 1 antibody (Hep Par 1) has a high positive predictive value for differentiating hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma.1 We report a case of metastatic breast cancer to the liver with hepatoid histology and strong positive staining for Hep Par 1 mimicking hepatocellular carcinoma. To our knowledge, primary breast carcinoma staining Hep Par 1 positive has not been reported in the setting of hepatic metastasis. This article is protected by copyright. All rights reserved...
May 9, 2018: Histopathology
Takafumi Hiromoto, Takashi Murakami, Yoichi Akazawa, Noriko Sasahara, Tsuyoshi Saito, Naoto Sakamoto, Hiroyuki Mitomi, Akihito Nagahara, Takashi Yao
AIMS: Recently, several morphological variants of traditional serrated adenoma (TSA) of the colorectum have been recognized, and mucin-rich TSA (MR-TSA) and serrated tubulovillous adenoma (S-TVA) were introduced as distinct morphological variants separate from conventional TSA (C-TSA). This study aimed to elucidate the immunohistochemical and genetic characteristics of MR-TSAs. METHODS AND RESULTS: We performed immunostaining for cytokeratins (e.g. CK7 and CK20), mucins (e...
May 5, 2018: Histopathology
Chitra Joseph, Athanasia Papadaki, Maryam Althobiti, Mansour Alsaleem, Mohammed A Aleskandarany, Emad A Rakha
Breast cancer (BC) is a heterogeneous disease that varies in presentation, morphological features, behaviour and response to therapy. High throughput molecular profiling studies have revolutionised our understanding of BC heterogeneity and demonstrated that molecular portraits of tumours are not only variable between tumours but also within individual tumours. Current evidence indicates that spatial and temporal intra-tumour heterogeneity of BC exists at levels beyond common anticipations. Intra-tumoural heterogeneity poses critical challenges in the diagnosis, prediction of behaviour and management of BC...
May 2, 2018: Histopathology
Colin Jr Stewart, Amy Pearn, Nicholas Pachter, Adeline Tan
AIMS: The observation of peri-tumoural granulomatous reactions (PGRs) in two endometrial carcinomas (ECs) with a PMS2-deficient/ MLH1-intact expression pattern led us to investigate whether PGRs in EC were specifically associated with DNA mismatch repair (MMR) protein deficiency, particularly PMS2 loss. METHODS AND RESULTS: Hysterectomy specimens from 22 MMR protein-intact and 54 MMR protein-deficient ECs were reviewed with specific attention to the presence of a PGR and a tumour-associated lymphoid reaction (including tumour-infiltrating lymphocytes (TILs) and stromal lymphoid infiltrates)...
April 30, 2018: Histopathology
Michael A den Bakker, Ronald A M Damhuis
Cancer treatment relies on accurate staging of which an essential aspect is determination of the size of a tumour. Measuring the size of a tumour in daily practice often proves problematic and results in rounding of values to approximate values. It has been shown that size values are more frequently reported with end digits of 0 or 5. We sought to determine if this observation holds true in our national cancer registry of breast and lung tumours. Data from patients with breast and lung cancer was retrieved from The Netherlands National Cancer Registry and analyzed for tumour size...
April 27, 2018: Histopathology
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