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Histopathology

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https://www.readbyqxmd.com/read/28316088/gata3-expression-in-benign-prostate-glands-with-radiation-atypia-a-diagnostic-pitfall
#1
Wei Tian, David Dorn, Shi Wei, Ronald D Sanders, Andres Matoso, Rajal B Shah, Jennifer Gordetsky
OBJECTIVE: Patients who have undergone prostate radiation are at an increased risk for developing urothelial carcinoma. Radiation changes can cause significant cytologic atypia in benign prostate glands that may mimic pagetoid spread of urothelial carcinoma. GATA3 is a common marker to differentiate prostatic adenocarcinoma from urothelial carcinoma. We investigated the expression of GATA3 in the epithelium of irradiated benign and malignant prostate tissue. METHODS: We performed a retrospective review of prostate cases with radiation atypia...
March 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28316074/a-comparison-of-alk-gene-rearrangement-and-alk-protein-expression-in-primary-lung-carcinoma-and-matched-metastasis
#2
Humberto E Trejo Bittar, Alyssa Luvison, Caitlyn Miller, Sanja Dacic
AIMS: The 2013 CAP/IASLC/AMP guideline for EGFR and ALK testing in lung carcinoma indicates that either the primary tumor or the metastasis is suitable for testing. The heterogeneity of gene mutations has been extensively studied, while similar reports on gene rearrangements are limited. The aim of this study was to determine if ALK status between primary tumor and matched metastasis differs. METHODS AND RESULTS: 15 ALK-FISH rearranged and 19 non-ALK-FISH rearranged adenocarcinomas were retrospectively collected based on availability of tissue from a matched metastatic site...
March 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28295534/mucin-rich-variant-of-traditional-serrated-adenoma-mrtsa-a-distinct-morphological-variant
#3
Sangeetha N Kalimuthu, Stefano Serra, Sara Hafezi-Bakhtiari, Richard Colling, Lai Mun Wang, Runjan Chetty
Traditional serrated adenomas (TSAs) account for 5% of serrated polyps, have villiform architecture, eosinophilic cells with a brush border and indented, flat-topped luminal serrations. However, some are composed of mucin-filled goblet cells (GC): a mucin-rich variant (MrTSA). The aim of this study was to determine if this variant has unique features compared to classic TSA (cTSA). 156 TSAs were retrieved from 2010-2016. Patient demographics, site of polyps, and 16 microscopic variables, were evaluated. TSAs containing 50% or more GCs were classified as MrTSAs...
March 13, 2017: Histopathology
https://www.readbyqxmd.com/read/28295498/the-pulmonary-artery-sarcoma-that-wasn-t
#4
LETTER
Ciara Murray, Ronan Ryan, Finbar O'Connell, Niall Conlon, Siobhan Nicholson
IgG4-related disease (IgG4-RD) is a multi-organ immune-mediated process with shared pathologic, serologic and clinical features. Initially described in the pancreas in association with elevated levels of serum IgG4, it is increasingly recognised as the unifying diagnosis of many fibro-inflammatory conditions previously thought to be isolated single-organ diseases. [1] The greatest diversity of presentation of IgG4-RD is seen in the lung with bronchovascular, nodular, alveolar interstitial and ground-glass opacity subtypes described, which can mimic malignant, infectious and other inflammatory disorders...
March 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28295494/seeds-in-the-appendix-a-fruitful-exploration
#5
Michela Campora, Chiara Trambaiolo Antonelli, Federica Grillo, Alberto Bragoni, Laura Cornara, Paola Migliora, Simona Pigozzi, Luca Mastracci
Our contribution aims at clarifying and underlining a possible finding which can pose an interesting twist in routine appendix diagnostics: seeds in the appendiceal lumen, their histological aspects and their differential diagnosis with parasites. We work in a training centre with a large referral practice for gastrointestinal pathology and often the most banal cases are those which pose problems to junior or non-expert pathologists. This short study aims at providing simple iconographic tables, which are not at the moment available either in publications or on the web, with the most frequent seeds encountered in our routine practice or sent for second opinion...
March 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28273383/optimal-block-sampling-of-routine-non-tumorous-gallbladders
#6
LETTER
Newton Acs Wong
Gallbladders are common specimens in routine histopathological practice and there are, at least in the United Kingdom and Australia, national guidance on how to sample gallbladders without macroscopically-evident, focal lesions/tumours (hereafter referred to as non-tumorous gallbladders).(1) Nonetheless, this author has seen considerable variation in the numbers of blocks used and the parts of the gallbladder sampled, even within one histopathology department. The recently re-issued 'Tissue pathways for gastrointestinal and pancreatobiliary pathology' from the Royal College of Pathologists (RCPath), first recommends sampling of the cystic duct margin and "at least one section each of neck, body and any focal lesion"...
March 8, 2017: Histopathology
https://www.readbyqxmd.com/read/28267250/counting-invasive-breast-cancer-cells-in-her2-silver-in-situ-hybridization-test-how-many-cells-are-enough
#7
António Polónia, Catarina Eloy, João Pinto, Ana Costa Braga, Guilherme Oliveira, Fernando Schmitt
AIM: Evaluate the intra and interobserver reproducibility of the HER2 ISH test in breast cancer measuring the impact of counting different numbers of invasive cancer cells. MATERIALS AND METHODS: A cohort of 101 primary invasive breast cancer cases were evaluated for HER2 gene amplification by SISH and the concordance among 4 observers with different levels of experience was determined counting different numbers of invasive cancer cells. The evaluation of the samples included scoring 20 nuclei, in three different areas...
March 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28261866/morphologic-and-immunophenotypic-features-of-hairy-cell-leukemia-involving-lymph-nodes-and-extranodal-tissues
#8
Jacqueline M Cortazar, Daniel J DeAngelo, Geraldine S Pinkus, Elizabeth A Morgan
Hairy cell leukemia (HCL) is a rare B-cell neoplasm that mainly affects bone marrow (BM), peripheral blood (PB), and spleen. Involvement of lymph nodes and extranodal structures is considered infrequent. Herein we describe our institutional experience of nodal (n=10) and extranodal (n=3) HCL over a thirty-year period. Ten patients had prior evidence of HCL within the BM or PB at a median 35.8 months before nodal/extranodal diagnosis (range, <1 to 175 months), and HCL was diagnosed concurrently within the bone marrow of 1 additional patient...
March 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28261852/acute-leukemia-with-a-pure-erythroid-phenotype-underrecognized-morphologic-and-cytogenetic-signatures-universally-associated-with-primary-refractory-disease-and-a-dismal-clinical-outcome
#9
David C Park, Neval Ozkaya, Scott B Lovitch
AIMS: Pure erythroid leukemia (PEL) is a very rare and aggressive subtype of acute myeloid leukemia defined by the World Health Organization (WHO) as a neoplastic proliferation of immature cells committed exclusively to the erythroid lineage comprising >80% of bone marrow cells and not meeting criteria of other well-defined myeloid neoplasms. The aim of this study was to describe the clinicopathologic features of acute leukemias with a pure erythroid phenotype (ALPEP) irrespective of their WHO classification and determine if ALPEP represents a distinct clinicopathologic entity...
March 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28257152/hpv-independent-vulvar-squamous-cell-carcinoma-has-a-worse-prognosis-than-hpv-associated-disease-a-retrospective-cohort-study
#10
Jessica N McAlpine, Samuel Leung, Angela Cheng, Dianne Miller, Aline Talhouk, C Blake Gilks, Anthony N Karnezis
BACKGROUND: Vulvar squamous cell carcinoma (VSCC) can be subdivided by HPV status into two clinicopathological entities. Studies on the prognostic significance of HPV in VSCC are discordant. METHODS: We performed a retrospective analysis of overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS) in 217 patients with VSCC. Cases were extracted from an era of more aggressive en bloc radical dissections (1985-1995) and more localized radical surgery through separate vulvar and groin excisions (1996-2005)...
March 3, 2017: Histopathology
https://www.readbyqxmd.com/read/28248435/trpm4-expression-is-associated-with-activated-b-cell-subtype-and-poor-survival-in-diffuse-large-b-cell-lymphoma
#11
Suet Kee Loo, Ewe Seng Ch'ng, Md Salzihan Md Salleh, Alison H Banham, Lars M Pedersen, Michael B Møller, Tina M Green, Kah Keng Wong
AIMS: Transient receptor potential channel melastatin 4 (TRPM4) is an ion channel that regulates influx of calcium cations (Ca(2+) ). Recent studies suggest that TRPM4 is an oncoprotein and its upregulated transcript level has been reported in diffuse large B-cell lymphoma (DLBCL). We aim to investigate TRPM4 protein expression pattern in non-malignant tissues and DLBCL cases, and its association with clinico-demographical parameters and survival in DLBCL. METHODS AND RESULTS: Analysis of publicly-available DLBCL microarray datasets showed that TRPM4 transcripts were upregulated in DLBCL compared to normal germinal centre B (GCB) cells, were more highly expressed in the activated B-cell-like DLBCL (ABC-DLBCL) subtype, and higher TRPM4 transcripts conferred worse overall survival (OS) in R-CHOP-treated DLBCL cases (P<0...
March 1, 2017: Histopathology
https://www.readbyqxmd.com/read/28239904/uicc-drops-the-ball-in-the-8th-edition-tnm-staging-of-urological-cancers
#12
Brett Delahunt, Lars Egevad, Hemamali Samaratunga, Murali Varma, Clare Verrill, John Cheville, Glen Kristiansen, Catherine Corbishley, Daniel M Berney
The publication of each successive edition of the TNM staging classification by the International Union Against Cancer (UICC) is widely anticipated, as the staging system is accepted and utilized internationally. Late in 2016 the eighth edition of the TNM classification (UICC 8)(1) was released but unfortunately, and despite the passage of six years since the publication of the seventh edition of the staging classification, the new edition incorporates little new data. In addition to this there are a number of differences between the staging recommendations of UICC 8 and those recently published as part of the 8(th) edition of the American Joint Committee for Cancer (AJCC 8)...
February 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28239886/fibrocartilaginous-mesenchymoma-of-bone-a-single-institution-experience-with-molecular-investigations-and-a-review-of-the-literature
#13
M Gambarotti, A Righi, D Vanel, S Cocchi, S Benini, F M Elli, G Mantovani, P Ruggieri, S Boriani, D Donati, M Sbaraglia, A P Dei Tos, P Picci
AIMS: Fibrocartilaginous mesenchymoma is a rare intraosseous lesion with a total of 25 cases described in the literature. This study describes the clinical, radiological, and histological features of eight new cases of fibrocartilaginous mesenchymoma collected at a single institution between 1982 and 2016. The presence of GNAS and IDH1/2 mutations and MDM2 amplification was explored to evaluate possible links between fibrocartilaginous mesenchymoma, fibrous dysplasia, dedifferentiated chondrosarcoma, and low-grade osteosarcoma...
February 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28231401/reappraisal-of-ebv-in-diffuse-large-b-cell-lymphoma-dlbcl-comparative-analysis-between-ebv-positive-and-negative-dlbcl-with-ebv-positive-bystander-cells
#14
Akiko Ohashi, Seiichi Kato, Akinao Okamoto, Yoko Inaguma, Akira Satou, Toyonori Tsuzuki, Nobuhiko Emi, Masataka Okamoto, Shigeo Nakamura
AIMS: Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) is defined as monoclonal EBV(+) B-cell proliferation affecting patients without any known immunosuppression. Non-neoplastic EBV(+) cells proliferating in or adjacent to EBV(-) DLBCL were reported recently, but their clinical significance is unclear. Thus, we investigated the prognostic impact of EBV(+) cells in DLBCL. METHODS AND RESULTS: We compared the clinico-pathological characteristics of 30 EBV(+) DLBCL patients and 29 and 604 EBV(-) DLBCL patients with and without EBV(+) bystander cells (median age of onset 71, 67, and 62 years, respectively)...
February 23, 2017: Histopathology
https://www.readbyqxmd.com/read/28231386/evaluating-the-effectiveness-of-rna-in-situ-hybridization-for-detecting-lung-adenocarcinoma-with-anaplastic-lymphoma-kinase-rearrangement
#15
Naoki Nakajima, Akihiko Yoshizawa, Kyoko Kondo, Mariyo Rokutan-Kurata, Masahiro Hirata, Ayako Furuhata, Shinji Sumiyoshi, Makoto Sonobe, Toshi Menju, Masanobu Momose, Masakazu Fujimoto, Hiroshi Date, Hironori Haga
AIMS: An easy and rapid assay for detecting mRNA in formalin-fixed paraffin-embedded samples (RNA-in situ hybridization; RNA-ISH) has been reported recently. We investigated the diagnostic accuracy of RNA-ISH for detecting lung adenocarcinoma (LA) with anaplastic lymphoma kinase (ALK) gene rearrangement. METHODS AND RESULTS: We tested ALK RNA-ISH on 11 resected LAs for which ALK fusion was confirmed by immunohistochemistry (IHC) and/or fluorescence in situ hybridization (FISH)...
February 23, 2017: Histopathology
https://www.readbyqxmd.com/read/28226191/in-reply-to-hynes-s-o-et%C3%A2-al-back-to-the-future-routine-morphological-assessment-of-the-tumour-microenvironment-is-prognostic-in-stage-ii-iii-colon-cancer-in-a-large-population-based-study
#16
LETTER
James Hugh Park, Campbell S Roxburgh, Joanne Edwards, Paul G Horgan, Donald C McMillan
We read with interest the recent study by Hynes et al (1) . In this study of 445 patients undergoing surgical resection of stage II/III colon cancer, the presence of a conspicuous peritumoural inflammatory cell infiltrate, as measured by the Crohn's like reaction (CLR) and a modification of the Klintrup-Mäkinen grade (examining only the lymphoid cell population), was associated with improved prognosis. A high proportion of tumour-associated stroma, as measured by a 'global' assessment of the tumour stroma percentage (TSP) but not 'focal' assessment, was also associated with poorer survival...
February 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28226185/p53-protein-accumulation-predicts-malignant-progression-in-barrett-s-metaplasia-a-prospective-study-of-275-patients
#17
Mamoun Younes, Keith Brown, Gregory Y Lauwers, Gulchin Ergun, Frank Meriano, A Carl Schmulen, Alberto Barroso, Atilla Ertan
AIMS: The purpose of this study was to determine prospectively whether p53 protein accumulation in biopsies of Barrett's metaplasia (BM) is a predictor of malignant progression, without relying on dysplasia grading. METHODS AND RESULTS: Sections of formalin fixed paraffin embedded tissue from the initial biopsies of 275 patients with BM, who had no high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC), were stained for p53 by immunohistochemistry. Mean follow up was 41 months...
February 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28226184/cd117-kit-is-a-useful-marker-in-the-diagnosis-of-plasmablastic-plasma-cell-myeloma
#18
Etan Marks, Yang Shi, Yanhua Wang
AIMS: Plasmablastic plasma cell myeloma (PPCM) is a rare morphological presentation of multiple myeloma and can resemble plasmablastic lymphoma (PBL), an HIV related lymphoid neoplasm, morphologically and immunophenotypically. We retrospectively searched for factors that could help differentiate these two entities. METHODS: We used Clinical Looking Glass (CLG), a data mining tool, to identify patients with a diagnosis of either PPCM or PBL with a CD117 test performed...
February 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28226180/a33-shows-similar-sensitivity-to-but-is-more-specific-than-cdx2-as-an-immunomarker-of-colorectal-carcinoma
#19
Newton A C S Wong, Lukasz A Adamczyk, Shanna Evans, Jayne Cullen, Anca Oniscu, Karin A Oien
AIMS: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC. METHODS AND RESULTS: As a pilot study, whole sections of 51 cases of liver metastatic carcinoma of different origins - colorectum (n=32), breast (n=3), oesophagogastric tract (n=4), lung (n=3), pancreas (n=8), and prostate (n=1) - were immunostained with CDX1, CDX2 and A33...
February 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28211946/extra-ampullary-duodenal-adenoma-a-clinicopathological-study
#20
Kazunori Hijikata, Tetsuo Nemoto, Yoshinori Igarashi, Kazutoshi Shibuya
AIM: Extra-ampullary duodenal adenoma (EADA) is a rare condition with poorly described clinicopathological details. In this study, we aimed to clinicopathologically characterize EADA. METHODS AND RESULTS: We performed a retrospective review of 44 serial cases of EADA. Each EADA was categorized as either gastric-type (n=5) or intestinal-type (n=39). All gastric-type adenomas were located in the first portion of the duodenum and exhibited a pedunculated shape. Gastric-type adenomas were classified into two subtypes: a pyloric gland type and a foveolar type...
February 17, 2017: Histopathology
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