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Histopathology

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https://www.readbyqxmd.com/read/27905140/herpes-simplex-infection-simulating-richter-transformation-a-series-of-four-cases-and-review-of-the-literature
#1
Alireza Salem, Sanam Loghavi, Joseph D Khoury, Rose Lou Marie C Agbay, Jeffrey L Jorgensen, Jeffrey L Medeiros
AIMS: Richter transformation (RT) occurs in 5-10% of patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and is associated with a poor outcome. Histologic manifestations of RT are variable and include an increase in the proportion of large cells including prolymphocytes, immunoblasts and other pleomorphic cells along with an increased proliferation rate and often necrosis. Rarely, superimposed Herpes simplex virus (HSV) infection involving lymph nodes in patients with CLL/SLL may mimic RT clinically and histologically...
December 1, 2016: Histopathology
https://www.readbyqxmd.com/read/27891692/smarce1-mutation-screening-in-classification-of-clear-cell-meningiomas
#2
Miriam J Smith, Soomin Ahn, Jung-Il Lee, Michael Bulman, Daniel du Plessis, Yeon-Lim Suh
AIMS: Clear cell meningioma is a rare subtype of meningioma and shows not only unusual histology, but also unique clinical features. Recently, SMARCE1 mutations have been shown to cause spinal and cranial clear cell meningiomas. We present 12 cases which were diagnosed with a clear cell meningioma in a single institution between 1997 and 2014, and investigate their SMARCE1 mutation status. METHODS AND RESULTS: To investigate the SMARCE1 mutation status of these tumours, we used a combination of Sanger sequencing and multiplex ligation dependent probe amplification analysis and also performed SMARCE1 immunohistochemical staining...
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27891673/igg4-related-disease-experience-of-100-consecutive-cases-from-a-specialist-centre
#3
Adrian C Bateman, Emma L Culver
AIMS: To describe the features of 100 consecutive cases referred to a single UK institution, in which a diagnosis of IgG4-related disease (IgG4-RD) was under consideration. METHODS AND RESULTS: The histological features were reviewed by a single histopathologist and cases categorised using the 2012 Boston criteria: Category 1 - histologically highly suggestive of IgG4-RD; 2 - probable histopathological features of IgG4-RD; 3 - insufficient histopathological features of IgG4-RD...
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27891660/small-bowel-ebv-positive-lymphoepithelioma-like-carcinoma-in-crohn-s-disease
#4
LETTER
Alessandro Vanoli, Antonio Di Sabatino, Livia Biancone, Michele Martino, Maria Cristina Macciomei, Francesca Zorzi, Francesco Pallone, Enrico Solcia, Gino Roberto Corazza
Lymphoepithelioma-like carcinoma (LEC) of the intestinal tract is extremely rare and yet unreported in the small bowel(1-3) . By definition, LEC is characterized by poorly developed tubular structures, associated with a prominent lymphoid infiltration of the stroma, and it is usually associated with Epstein Barr Virus (EBV) infection. This article is protected by copyright. All rights reserved.
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27891654/the-relationship-between-oestrogen-receptor-alpha-phosphorylation-and-the-tumour-microenvironment-in-patients-with-primary-operable-ductal-breast-cancer
#5
Kelvin K W Cheng, Ashley Dickson, Fadia J A Gujam, Donald C McMillan, Joanne Edwards
AIMS: Although the role of phosphorylation of oestrogen receptor (ER) at serines 118 (p-S118) and 167 (p-S167) have been studied, the relationship between p-S118, p-S167 and the tumour microenvironment in ER-positive primary operable ductal breast cancers have not been investigated. The aims of this study are to investigate (1) the relationship between p-S118/p-S167 and the tumour microenvironment and (2) the effect of p-S118/167 on survival and recurrence in ER-positive primary operable ductal breast cancers...
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27882585/significance-of-a-solid-component-in-the-papillary-thyroid-carcinoma-associated-with-clinicopathological-parameters
#6
Ryuji Ohashi, Kiyoko Kawahara, Shigeki Namimatsu, Takehito Igarashi, Takashi Sakatani, Iwao Sugitani, Zenya Naito
AIMS: Solid variant of papillary thyroid carcinoma (SVPTC) is characterized by a solid component (SC) involving more than 50% of the tumor with the preservation of the classical cytological features of papillary thyroid carcinoma (PTC). However, clinical significance of SC in PTC has rarely been examined. Herein, we retrospectively investigated the clinicopathological features of PTC with various degree (10 to 85%) of SC (PTCSC). METHODS: Patients with PTCSC (n=27) were stratified into SC-major (SC >50% of the tumor) and SC-minor (SC <49%) groups...
November 24, 2016: Histopathology
https://www.readbyqxmd.com/read/27878841/intraductal-papillary-mucinous-neoplasms-of-the-pancreas-reporting-clinically-relevant-features
#7
REVIEW
Marco Del Chiaro, Caroline Verbeke
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas can exhibit a wide spectrum of macroscopic and microscopic appearances. This not only causes occasional difficulties for the reporting pathologist in distinguishing these tumours from other lesions, but is also relevant clinically. As evidence accumulates, it becomes clear that multiple macroscopic and histological features of these neoplasms are relevant to the risk for malignant transformation and, consequently, of prime importance for clinical patient management...
November 22, 2016: Histopathology
https://www.readbyqxmd.com/read/27864835/intrahepatic-cholangiocarcinoma-frequently-shows-loss-of-bap1-and-pbrm1-expression-and-demonstrates-specific-clinicopathologic-and-genetic-characteristics-with-bap1-loss
#8
Kento Misumi, Akimasa Hayashi, Junji Shibahara, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fukayama
AIMS: BAP1 and PBRM1 expression loss has been observed in multiple cancers, including intrahepatic cholangiocarcinoma (ICC). We investigated BAP1 and PBRM1 expression in ICC using immunohistochemistry, and analyzed its association with clinicopathological and genetic features, including two histologic subtypes. METHODS AND RESULTS: Whole-section slides of 108 consecutive primary ICC cases were immunostained against BAP1 and PBRM1. Complete loss of BAP1 and PBRM1 was observed in 21 (19...
November 19, 2016: Histopathology
https://www.readbyqxmd.com/read/27864998/rnf43-mutation-frequently-occurs-with-gnas-mutation-and-mucin-hypersecretion-in-intraductal-papillary-neoplasms-of-the-bile-duct
#9
Jia-Huei Tsai, Jau-Yu Liau, Chang-Tsu Yuan, Mei-Ling Cheng, Ray-Hwang Yuan, Yung-Ming Jeng
RNF43 is a tumor suppressor gene that is frequently mutated in intraductal papillary mucinous neoplasms of the pancreas (IPMN). RNF43 suppresses the Wnt/β-catenin signaling pathway. We conducted mutation analysis of RNF43 in intraductal papillary neoplasms of the bile duct (IPNBs) and identified RNF43 mutation in 6 (12%) out of 50 IPNBs. RNF43 mutation was more frequent in the intestinal subtype of IPNB (17%) than in the gastric/pancreatobiliary subtype (5%). There were a strong association of RNF43 mutation with GNAS (P = ...
November 16, 2016: Histopathology
https://www.readbyqxmd.com/read/27864989/the-mitosis-specific-marker-phosphohistone-h3-phh3-is-an-independent-prognosticator-in-uterine-smooth-muscle-tumors-an-outcome-based-study
#10
Kin-Long Chow, Ka-Yu Tse, Ching-Lung Cheung, Ka-Wing Wong, Annie N Y Cheung, Richard W C Wong, Alice N H Chan, Nancy W F Yuen, Hextan Y S Ngan, Philip P C Ip
: Accurate mitosis-counting, which is important in the diagnosis of uterine smooth muscle tumors (USMT), is often difficult and subjective. The mitosis-specific immunohistochemical marker phosphohistone H3 (PHH3) has been shown to be diagnostically useful but its expression, in relation to outcome, has not been thoroughly investigated. AIMS AND METHODS: PHH3 expression was evaluated on 55 leiomyosarcomas (LMSs), 26 smooth muscle tumors of uncertain malignant potential (STUMPs), 18 leiomyomas with bizarre nuclei (LBNs) and 12 leiomyomas (LMs)...
November 16, 2016: Histopathology
https://www.readbyqxmd.com/read/27864982/unusual-findings-in-common-peripheral-ossifying-fibromas-transepithelial-elimination-and-epithelial-inclusion
#11
LETTER
Fumio Ide, Kentaro Kikuchi, Hideki Sakashita, Takashi Muratsu, Kaoru Kusama
Peripheral ossifying fibroma (POF) is by far the most common of the reactive fibro-osseous processes affecting the gingiva.(1) Histologically, POF shows a wide spectrum, the types and patterns of calcification and ossification varying in both amount and appearance, mostly depending on the stage of development, although the diagnosis is straightforward nevertheless.(1) Here we describe two rare findings in mature lesions of POF: transepithelial elimination (TEE) of bony sequestrae (case 1) and multiple inclusions of odontogenic epithelium in the intervening fibrous stroma (case 2)...
November 16, 2016: Histopathology
https://www.readbyqxmd.com/read/27859460/diagnostic-utility-of-bap1-and-ezh2-expression-in-malignant-mesothelioma
#12
Aya Shinozaki-Ushiku, Tetsuo Ushiku, Shigeki Morita, Masaki Anraku, Jun Nakajima, Masashi Fukayama
AIMS: Malignant mesothelioma is a highly aggressive cancer usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of the study is to evaluate the diagnostic utility and prognostic significance of BRCA1-Associated Protein 1 (BAP1) and enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) in malignant mesothelioma. METHODS AND RESULTS: The expression of BAP1 and EZH2 was investigated by immunohistochemistry in 32 malignant mesothelioma and 44 benign mesothelial proliferative lesions, including well-differentiated papillary mesothelioma (n = 4), mesothelial inclusion cyst (n = 22), and reactive mesothelial hyperplasia (n = 18)...
November 11, 2016: Histopathology
https://www.readbyqxmd.com/read/27862202/-inside-out-p120-immunostaining-pattern-in-invasive-micropapillary-carcinoma-of-breast-additional-unequivocal-evidence-of-reversed-polarity
#13
LETTER
Marcos Lepe, Elizabeth T Kalife, Joyce Ou, M Ruhul Quddus, Kamaljeet Singh
Invasive micropapillary carcinoma (IMPC) of the breast is a distinct histologic variant of ductal carcinoma in which tumor cells display reverse polarity. Tumor cells form morula-like clusters and tubular structures suspended in a clear space, with a characteristic "inside-out" pattern.(1) Although IMPC can be readily identified by its typical histological features, immunohistochemistry (IHC) for epithelial membrane antigen (EMA) and sialyl Lewis X can be employed to confirm this "inside-out" pattern, especially where the IMPC component is focal...
November 8, 2016: Histopathology
https://www.readbyqxmd.com/read/27801954/the-who-2016-classification-of-testicular-non-germ-cell-tumours-a-review-and-update-from-the-international-society-of-urological-pathology-testis-consultation-panel
#14
REVIEW
Muhammad T Idrees, Thomas M Ulbright, Esther Oliva, Robert H Young, Rodolfo Montironi, Lars Egevad, Daniel Berney, John R Srigley, Jonathan I Epstein, Satish K Tickoo
The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of the germ cell tumours; however, several modifications were also initiated for the non-germ cell tumours...
November 1, 2016: Histopathology
https://www.readbyqxmd.com/read/27791295/vascular-architecture-as-diagnostic-marker-for-differentiation-of-who-thymoma-subtypes-and-thymic-carcinoma
#15
Frederick Pfister, Hussam Hussain, Djeda Belharazem, Svenja Busch, Katja Simon-Keller, Dominic Becker, Eva Pfister, Ralf Rieker, Philipp Ströbel, Alexander Marx
BACKGROUND: Thymomas and thymic squamous cell carcinomas (TSQCC) are rare thymic epithelial tumors. Data on angiogenesis and vascular phenotype in these tumors is limited, and no study took histological WHO subtypes into account. METHODS: Vascular density, diameter and architecture and expression of SMA, PDGFRb, VEGFR1 and VEGFR2 were investigated in WHO type A, AB, B1, B2 and B3 thymomas and TSQCC, using immuno-stainings, quantitative morphometry and tumor vessel isolation by trypsin digestion...
October 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27790742/the-utility-of-etv1-etv4-and-etv5-rna-in-situ-hybridization-in-the-diagnosis-of-cic-dux4-sarcomas
#16
Steven C Smith, Nallasivam Palanisamy, Elizabeth Martin, Jorge Almenara, Jonathan B McHugh, Eun-Young Karen Choi, David R Lucas, Bryan L Betz, Dafydd Thomas, Rajiv M Patel
AIMS: A recently characterized group of undifferentiated small round cell sarcomas harbours fusions of the genes CIC and DUX4. Studies report a distinctive gene expression profile for these sarcomas, including expression of E26 transformation specific (ETS)-family protooncogenic transcription factors ETV1, ETV4, and ETV5. To test the utility of an ancillary diagnostic technique for these tumors, we evaluated chromogenic RNA in situ hybridization assays for ETV1, ETV4, and ETV5, as diagnostic adjuncts for this emerging group of highly malignant sarcomas...
October 27, 2016: Histopathology
https://www.readbyqxmd.com/read/27782313/cytotoxic-ebv-positive-large-b-cell-lymphoma-a-breg-derived-neoplasia
#17
Valentina Tabanelli, Vanessa Santiago-Pacheco, Mario Corbellino, Angelica Calleri, Claudio Agostinelli, Carlo Parravicini, Stefano A Pileri
AIMS: A new subtype of granzyme B (GrB) producing "regulatory B cells" (Bregs) has been recently described; these peculiar cytotoxic B-cells are significantly increased in interleukin-21 (IL-21)-rich settings, and in particular during HIV and EBV infection. Our aim is to report a unique case of an EBV-positive diffuse large B-cell lymphoma (DLBCL) with cytotoxic features arisen in an HIV+ patient, and to understand if this lesion may represent a proliferation of neoplastic cytotoxic Bregs...
October 26, 2016: Histopathology
https://www.readbyqxmd.com/read/27782306/prognostic-stratification-of-oestrogen-receptor-positive-her2-negative-lymph-node-negative-class-of-breast-cancer
#18
Emad A Rakha, Devika Agarwal, Andrew R Green, Ibraheem Ashankyty, Ian O Ellis, Graham Ball, Mohammed A Alaskandarany
: Multigene assay is currently recommended for prognostic stratification of the clinically indeterminate group of breast cancer (BC) patients defined as lymph node (LN)-negative, oestrogen receptor (ER)-positive HER2-negative (LN-/ER+/HER2-) to determine the use of chemotherapy. However this cohort, comprising approximately 40% of BC, is not a homogeneous group and shows variable outcome. This study aims to determine the prognostic value of routinely assessed variables, singly and in combination, in the LN-/ER+/HER2- BC...
October 26, 2016: Histopathology
https://www.readbyqxmd.com/read/27775850/clinicopathological-characteristics-and-genomic-profile-of-primary-sinonasal-tract-diffuse-large-b-cell-lymphoma-dlbcl-reveals-gain-at-1q31-and-rgs1-encoding-protein-high-rgs1-immunohistochemical-expression-associates-with-poor-overall-survival-in-dlbcl-nos
#19
Joaquim Carreras, Yara Yukie Kikuti, Sílvia Beà, Masashi Miyaoka, Shinichiro Hiraiwa, Haruka Ikoma, Ryoko Nagao, David Martin-Garcia, Itziar Salaverria, Ai Sato, Ichiki Akifumi, Giovanna Roncador, Juan F Garcia, Kiyoshi Ando, Elias Campo, Naoya Nakamura
AIMS AND METHODS: We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B-cell lymphoma (DLBCL(sn) ) in a series of 240 DLBCL(all ()(NOS)()) including DLBCL(sn) training set (n=11) and validation set (n=18), and DLBCL(non-sn) (n=211). RESULTS: In the training set 82% had non-GCB phenotype and 18% were EBER(+) . The genomic profile showed gains((+)) of 1q21.3q31.2 (55%), 10q24.1 (46%), 11q14.1 (46%) and 18q12.1q23 (46%); losses((-)) of 6q26q27 (55%) and 9p21...
October 24, 2016: Histopathology
https://www.readbyqxmd.com/read/27767239/morphology-and-genetics-of-pyloric-gland-adenomas-in-familial-adenomatous-polyposis
#20
Wenzel M Hackeng, Elizabeth A Montgomery, Francis M Giardiello, Aatur D Singhi, Marija Debeljak, James R Eshleman, Michael Vieth, G Johan A Offerhaus, Laura D Wood, Lodewijk A A Brosens
BACKGROUND: Gastric pyloric gland adenomas (PGAs) are rare epithelial polyps that are more commonly found in autoimmune atrophic gastritis and familial adenomatous polyposis. Little is known about the morphology and genetics of PGAs in familial adenomatous polyposis. AIMS: PGAs in familial adenomatous polyposis are studied morphologically and genetically. Findings in FAP associated PGAs are compared to sporadic PGAs and related lesions such as oxyntic gland adenoma (OGA) to increase our understanding of these rare polyps...
October 21, 2016: Histopathology
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