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Wenzel M Hackeng, Elizabeth A Montgomery, Francis M Giardiello, Aatur D Singhi, Marija Debeljak, James R Eshleman, Michael Vieth, G Johan A Offerhaus, Laura D Wood, Lodewijk A A Brosens
BACKGROUND: Gastric pyloric gland adenomas (PGAs) are rare epithelial polyps that are more commonly found in autoimmune atrophic gastritis and familial adenomatous polyposis. Little is known about the morphology and genetics of PGAs in familial adenomatous polyposis. AIMS: PGAs in familial adenomatous polyposis are studied morphologically and genetically. Findings in FAP associated PGAs are compared to sporadic PGAs and related lesions such as oxyntic gland adenoma (OGA) to increase our understanding of these rare polyps...
October 21, 2016: Histopathology
Yoko Kojima, Koji Okudela, Mai Matsumura, Takahiro Omori, Tomohisa Baba, Akimasa Sekine, Tetsukan Woo, Shigeaki Umeda, Tamiko Takemura, Hideaki Mitsui, Takehisa Suzuki, Yoko Tateishi, Tae Iwasawa, Hiromasa Arai, Michihiko Tajiri, Takashi Ogura, Yoichi Kameda, Munetaka Masuda, Kenich Ohashi
AIMS: To investigate the pathological features of idiopathic interstitial pneumonia (IIP) - associated pulmonary adenocarcinoma. METHODS: Surgically resected adenocarcinomas associated with IIP (the IIP group) and adenocarcinomas without IIP (the non-IIP group) were subjected. We here further focused on adenocarcinomas that developed in the honeycomb lesions. Adenocarcinomas in the IIP group were subdivided into two groups, one group included tumors connected to bronchiolar metaplasia in honeycomb lesions (the H-IIP group) and the other included tumors unrelated to honeycomb lesions (the NH-IIP group)...
October 19, 2016: Histopathology
Sean R Williamson, Brett Delahunt, Cristina Magi-Galluzzi, Ferran Algaba, Lars Egevad, Thomas M Ulbright, Satish K Tickoo, John R Srigley, Jonathan I Epstein, Daniel M Berney
Since the last World Health Organization (WHO) Classification scheme for tumours of the urinary tract and male genital organs, there have been a number of advances in the understanding, classification, immunohistochemistry, and genetics of testicular germ cell tumours. The updated 2016 draft classification was discussed at an International Society of Urological Pathology (ISUP) Consultation on Testicular and Penile Cancer. This review addresses the main updates to germ cell tumour classification. Major changes include a pathogenetically derived classification using germ cell neoplasia in situ (GCNIS) as a new name for the precursor lesion, as well as distinction of prepubertal (non-GCNIS-derived) from postpubertal-type tumours (GCNIS-derived), acknowledging the existence of rare benign prepubertal-type teratomas in the postpubertal testis...
October 17, 2016: Histopathology
Carolina Martínez-Ciarpaglini, Carles Saus, Nohelia Rojas-Ferrer, Liria Terrádez, Marta Serra, Rafael Botella-Estrada, Carlos Monteagudo
we report three cases of pure cutaneous Rosai-Dorfman disease (RDD) showing prominent nuclear pleomorphism. This unusual finding confers a worrisome appearance to these lesions, challenging their recognition and creating difficulty in the differential diagnosis with malignant neoplasms. This article is protected by copyright. All rights reserved.
October 15, 2016: Histopathology
Ahmed Ali Elsayed, Akira Satou, Ahmed E Eladl, Seiichi Kato, Shigeo Nakamura, Naoko Asano
AIMS: To report the clinicopathologic features of EBV-positive (EBV(+) ) grey zone lymphoma (GZL) with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (CHL). METHODS AND RESULTS: We report the clinicopathologic features of 14 cases of EBV(+) GZL in Japan. The control group included 173 cases of EBV(+) CHL and 64 cases of EBV(+) DLBCL of the elderly (polymorphous type). Patients included 10 men and 4 women with a median age of 62 years...
October 13, 2016: Histopathology
Andrew G Nicholson, Frank Detterbeck, Alexander Marx, Anja C Roden, Alberto M Marchevsky, Kiyoshi Mukai, Gang Chen, Mirella Marino, Michael A den Bakker, Woo-Ick Yang, Meagan Judge, Lynn Hirschowitz
AIMS: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation formed by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists-Association Canadienne des Pathologists (CAP-ACP) in association with the Canadian Partnership Against Cancer (CPAC), and the European Society of Pathology (ESP). Its goal is to produce standardised, internationally agreed, evidence-based datasets for use throughout the world...
October 13, 2016: Histopathology
Tomonori Sasahira, Miyako Kurihara, Yukiko Nishiguchi, Chie Nakashima, Tadaaki Kirita, Hiroki Kuniyasu
AIMS: Pancreatic adenocarcinoma upregulated factor (PAUF) is a novel secretory protein, which promotes tumor progression, metastasis, and poor prognosis in pancreatic, cervical, and colorectal carcinoma. It is also associated with gemcitabine resistance in pancreatic cancer cells. However, the expression and function of PAUF in oral squamous cell carcinoma (OSCC) remain unknown. METHODS AND RESULTS: We performed an immunohistochemical analysis of PAUF in 222 clinicopathologically characterized cases of OSCC...
October 5, 2016: Histopathology
Dorian R A Swarts, Martina Rudelius, Sandra M H Claessen, Jack P Cleutjens, Stefan Seidl, Marco Volante, Frans C S Ramaekers, Ernst J M Speel
AIMS: Currently pulmonary carcinoids are separated into typical (TC) and atypical (AC) based on mitotic count and presence of necrosis, according to the WHO. At variance with gastroenteropancreatic neuroendocrine tumors, which are graded based on mitotic count and Ki-67 proliferative index, the use of Ki-67 for grading pulmonary carcinoids is still under debate. METHODS AND RESULTS: In this study we evaluated the prognostic impact of Ki-67 assessment in a multicenter cohort of 201 carcinoids (147 TCs, 54 ACs), using manual analysis (2000 cells counted) and digital image analysis (in-house Leica Qwin program; ≥ 4500 cells counted)...
October 4, 2016: Histopathology
Eduardo Rodrigues Fregnani, Danyel Elias da Cruz Perez, Oslei Paes de Almeida, Felipe Paiva Fonseca, Fernando Augusto Soares, Gilberto de Castro Junior, Fábio Abreu de Alves
AIMS: The aim of this study was to investigate whether the expression of BRAF-V600E determines an aggressive clinical and molecular presentation of ameloblastoma. METHODS AND RESULTS: Ninety-three cases of solid ameloblastomas were arranged in a 1.0-mm tissue microarray block. Immunohistochemistry against a large panel of cytokeratins (CK), epidermal growth factor receptor (EGFR), parathyroid hormone-related peptide (PTHrP), syndecan-1, Ki67, p53, and BRAF-V600E were done...
September 28, 2016: Histopathology
Colin Jr Stewart, Maxine L Crook
AIMS: To review the clinicopathological features of 14 cases of CIN 3-like squamous cell carcinoma (SCC) of the cervix and to investigate possible mechanisms of tumour invasion in the CIN 3-like and 'conventional' (infiltrative) tumour components. METHODS AND RESULTS: The median patient age was 43.4 years. Of the twelve cases with known stage, eight were stage IB and four were stage II. Initial biopsies were often misinterpreted as CIN 3 alone or CIN 3 with only superficial stromal invasion and eight patients underwent multiple biopsy procedures prior to definitive diagnosis: upon review, an earlier diagnosis was possible in six of these cases...
September 28, 2016: Histopathology
Makoto Eizuka, Kodai Tsuchida, Ryo Sugimoto, Kazuyuki Ishida, Noriyuki Uesugi, Syunichi Yanai, Risaburo Akasaka, Yosuke Toya, Keisuke Kawasaki, Syotaro Nakamura, Takayuki Matsumoto, Tamotsu Sugai
Intravascular papillary endothelial hyperplasia (IPEH) is a proliferation of endothelial cells in a papillary formation that occurs within a blood vessel lumen. Although IPEH occurs mainly in the skin, head-and-neck region, and fingers, IPEH occurring in the gastrointestinal tract is very rare (1). Furthermore, to the best of our knowledge, its occurrence in the stomach has never been reported. This article is protected by copyright. All rights reserved.
September 27, 2016: Histopathology
Rebecca K L Griggs, Marco R Novelli, D Scott A Sanders, Bryan F Warren, Geraint T Williams, Philip Quirke, Neil A Shepherd
The diagnostic difficulties of differentiating epithelial misplacement from invasive cancer in colorectal adenomatous polyps have been recognised for many years. Nevertheless, the introduction of population screening in the UK has provided extraordinary diagnostic problems. Larger sigmoid colonic adenomatous polyps, those most likely to show epithelial misplacement, are specifically selected into such screening programmes because these polyps are likely to bleed and screening is based on the detection of occult blood...
September 27, 2016: Histopathology
Preetha Ramalingam, Sabrina Croce, W Glenn McCluggage
AIM: Abnormalities of SMARCB1 (INI1) gene, a member of the SWI/SNF pathway, are found in neoplasms with rhabdoid morphology such as malignant rhabdoid tumor of the kidney and atypical teratoid/rhabdoid tumor of the central nervous system. SMARCA4 (BRG1), another member of the SWI/SNF pathway, which is mutated in virtually all small cell carcinomas of the ovary, hypercalcemic type, has been investigated in endometrial carcinomas and mutations with resultant loss of immunohistochemical staining has been demonstrated in some endometrial undifferentiated carcinomas /dedifferentiated carcinomas...
September 22, 2016: Histopathology
Abir A Muftah, Mohammed Aleskandarany, Sultan N Sonbul, Christopher C Nolan, Maria Diez Rodriguez, Carlos Caldas, Ian O Ellis, Andrew R Green, Emad A Rakha
BACKGROUND AND AIM: Although oestrogen receptor (ER)-negative breast cancers (BC) do not respond to hormone therapy, the response of ER-positive BC is reported to be variable which may suggest a dose dependent effect. This study aimed to assess the pattern of ER-expression in BC at the protein (IHC) and transcriptome (microarray-based gene expression) levels. MATERIALS AND METHODS: ER IHC expression was assessed in a large series of BC including 3649 core biopsies and 1892 cases prepared as TMA stained using specific antibodies...
September 20, 2016: Histopathology
I Weng Lao, Lin Yu, Jian Wang
AIMS: We describe an additional series of superficial CD34-positive fibroblastic tumor, a newly described neoplasm, to enhance the recognition of an emerging novel entity. METHODS AND RESULTS: The clinicopathological features and immunophenotypes of 11 cases of superficial CD34-positive fibroblastic tumor were studied. There were 8 males and 3 females with a median age of 36 years. Tumor occurred in the thigh (n=4), buttock (n=3), shoulder (n=2), upper arm (n=1) and waist (n=1)...
September 16, 2016: Histopathology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
BACKGROUNDS/AIMS: Combined hepatocellular-cholangiocarcinoma (cHC-CC), which generally has a poor prognosis, comprises of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and diverse components with intermediate features between HCC and CC. Histological subtypes with stem cell features (the SC subtype) have different clinicopathological significance in cHC-CC. The mutational status may reflect the clinicopathological subgroup of cHC-CC together with the histological subtype. METHODS: We examined the mutational statuses of KRAS, IDH1 or 2 (IDH1/2), ARID1A, the TERT promoter, and p53 and their relationships with clinicopathological features in 53 patients with cHC-CC...
September 16, 2016: Histopathology
Keen Shawn Foong, Stephen McGrath, Lai Mun Wang, Neil A Shepherd
Following our recently published correspondence on this subject(1) , we have been made aware that the UICC/TNM have given a view on the staging of colorectal cancer in neo-adjuvant therapy-naïve colorectal cancer patients, whereby acellular mucin in lymph nodes has been detected. Like us, they view such a finding as representing lymph node disease positive for metastatic colorectal cancer(2) . This article is protected by copyright. All rights reserved.
September 16, 2016: Histopathology
Diogo Morbeck, Aline Caldart Tregnago, Glauco Baiocchi Netto, Carlos Sacomani, Patricia Maria Peresi, Cynthia Toledo Osório, Luciana Schutz, Stephania Martins Bezerra, Louise de Brot, Isabela Werneck Cunha
AIMS: GATA3 has been reported as a specific urothelial marker among organs in the pelvic region and has been classified as highly sensitive and specific for urothelial and breast carcinomas. Our aim was to verify GATA3 expression in extramammary Paget disease (EMPD) and check if it can be use to differentiate primary vulvar Paget disease (PVPD) from pagetoid urothelial intraepithelial neoplasia (PUIN). Also we analyzed Her2 protein expression and HER2 gene amplification and its role as prognostic factors in EMPD METHODS AND RESULTS: We analyzed GATA3 and Her2 expression in 11 primary vulvar Paget disease and also 2 PUIN cases...
September 16, 2016: Histopathology
Kung-Chao Chang, Paul Chih-Hsueh Chen, Yao Chang, Yu-Hsuan Wu, Ya-Ping Chen, Chien-Hsien Lai, L Jeffrey Medeiros, Ih-Jen Su, Hsei-Wei Wang
AIMS: Previously, we reported an association between Epstein-Barr virus (EBV)-positive Hodgkin lymphoma (HL), older age and poorer prognosis. The mechanisms underlying this association remain unclear. METHODS AND RESULTS: Transfection of HL cell lines with EBV-latent membrane protein-1 (LMP1) resulted in upregulation of many cytokine genes as assessed by using oligonucleotide microarrays. Three upregulated cytokines, were validated by using an inflammatory cytokine protein array: MIP-1α, MIP-1β, IL-13...
September 16, 2016: Histopathology
Robert H Young
I very much enjoyed the recent review on the evolution of knowledge concerning the nomenclature of pre-invasive germ cell malignancy in the testis (1) and would like to congratulate Dr. Berney and his co-authors and indeed the journal for publishing this short but interesting document of an historical nature. There is in certain quarters much less knowledge and consideration of historical aspects of pathology, including giving credit to previous eminent authorities, and how knowledge developed, than is ideal...
September 15, 2016: Histopathology
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