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Histopathology

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https://www.readbyqxmd.com/read/29350783/malignant-mesothelioma-in-situ
#1
Andrew Churg, Harry Hwang, Lawrence Tan, Gefei Qing, Altaf Taher, Amy Tong, AnaMaria Bilawich, Sanja Dacic
The existence of malignant mesothelioma in situ (MIS) is often postulated, but there are no accepted morphologic criteria for making such a diagnosis. Here we report two cases that appear to be true MIS on the basis of in situ genomic analysis. In one case the patient had repeated unexplained pleural unilateral effusions. Two thoracoscopies 9 months apart revealed only visually normal pleura. Biopsies from both thoracoscopies showed only a single layer of mildly reactive mesothelial cells. However, these cells had lost BAP1 and showed loss of CDKN2A ("p16″) by FISH...
January 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29350777/the-pathology-of-lumbosacral-lipomas-macroscopic-and-microscopic-disparity-have-implications-for-embryogenesis-and-mode-of-clinical-deterioration
#2
Victoria Jones, Victoria Wykes, Nicki Cohen, Dominic Thompson, Thomas S Jacques
AIMS: Lumbosacral lipomas (LSL) are congenital disorders of the terminal spinal cord region that have the potential to cause significant spinal cord dysfunction in children. They are of unknown embryogenesis with variable clinical presentation and natural history. It is unclear whether the spinal cord dysfunction reflects a primary developmental dysplasia or whether it occurs secondarily to mechanical traction (spinal cord tethering) with growth. Whilst different anatomical subtypes are recognised and classified according to radiological criteria, these subtypes correlate poorly with clinical prognosis...
January 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29323731/expression-of-pd-l1-correlates-with-pleomorphic-morphology-and-histological-patterns-of-non-small-cell-lung-carcinomas
#3
Francois Ng Kee Kwong, Ute Laggner, Olivia Mc Kinney, James Croud, Alexandra Rice, Andrew G Nicholson
AIMS: With immunomodulatory therapy being integrated into treatment regimes for non-small cell carcinoma (NSCLC), we prospectively collected data on the immunohistochemical profile of tumours assessed in our institution and correlated this with morphological tumour features. METHODS AND RESULTS: Immunohistochemistry for PD-L1 was considered adequate when more than 100 tumour cells were seen microscopically. When adequate, PD-L1 staining was scored as <1%, ≥ 1-49% or ≥ 50% positive membrane staining within tumour cells only...
January 11, 2018: Histopathology
https://www.readbyqxmd.com/read/29323728/3d-reconstruction-of-prostate-cancer-architecture-with-serial-immunohistochemical-sections-hallmarks-of-tumour-growth-tumour-compartmentalization-and-implications-for-grading-and-heterogeneity
#4
Yuri Tolkach, Stefan Thomann, Glen Kristiansen
BACKGROUND: Conventional morphology of the prostate cancer (PCA) considers only two-dimensional architecture of the tumour. Our aim was to examine the feasibility of 3D-reconstruction of tumour morphology based on multiple consecutive histological sections and to decipher relevant features of PCA architecture. METHODS: Seventy-five consecutive histological sections (5μm) of a typical prostate adenocarcinoma (Gleason-Score 3+4=7) were immunostained (Pan-Cytokeratin) and scanned for further 3D reconstructions with Fiji / ImageJ software...
January 11, 2018: Histopathology
https://www.readbyqxmd.com/read/29314220/histopathology-of-synovial-cysts-of-the-spine
#5
Ivan Chebib, Connie Y Chang, Joseph H Schwab, Darcy A Kerr, Vikram Deshpande, G Petur Nielsen
AIMS: Cystic lesions derived from the synovial and ligamentous structures of the spine have varied histologic appearances. Not uncommonly, there is discrepancy between the clinico-radiologic diagnosis and histology. Therefore, we sought to characterize the histologic features of tissue submitted as "synovial cysts" of the spine. METHODS: Resected specimens of the spine labeled "synovial cysts" and "lumbar cysts" were histologically evaluated and classified based on histopathologic features...
January 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29314186/aggressive-nk-cell-leukaemia-and-extranodal-nk-t-cell-lymphoma-are-two-distinct-diseases-that-differ-in-their-clinical-presentation-and-cytogenetic-findings
#6
Ching-Fen Yang, Chih-Yi Hsu, Donald Ming-Tak Ho
AIMS: Distinguishing between aggressive NK-cell leukaemia (ANKCL) and extranodal NK/T-cell lymphoma (ENKTCL) with secondary bone marrow involvement is challenging, as they are rare bone marrow NK/T-cell neoplasms and share similar features. METHODS AND RESULTS: We studied bone marrow NK/T-cell neoplasms by classifying them into those with no extramedullary mass (group 1, 8 cases) and those with extramedullary mass (group 2, 13 cases). Both groups showed similar clinical presentations and pathological features...
January 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29314151/comparison-of-ebv-positive-mucocutaneous-ulcer-ebvmcu-associated-with-treated-lymphoma-or-methotrexate-in-japan
#7
Teerada Daroontum, Kei Kohno, Ahmed E Eladl, Akira Satou, Ayako Sakakibara, Shoichi Matsukage, Naoki Yakushiji, Charin Ya-In, Shigeo Nakamura, Naoko Asano, Seiichi Kato
AIMS: The present study compared treated lymphoma-associated EBV-positive mucocutaneous ulcer (EBVMCU) and methotrexate (MTX)-associated EBVMCU. METHODS AND RESULTS: Of a series of 15 Japanese patients (11 women, 4 men; median age 74 years, range 35-84 years). 7 received MTX for autoimmune disease and 8 developed EBVMCU after treatment of malignant lymphoma (diffuse large B-cell lymphoma [n=4] without EBV association, adult T-cell leukaemia/lymphoma [n=2], angioimmunoblastic T-cell lymphoma [n=1], and follicular lymphoma [n=1])...
January 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29314176/improved-diagnostic-stratification-of-digitised-barrett-s-oesophagus-biopsies-by-tp53-immunohistochemical-staining
#8
M J van der Wel, L C Duits, R E Pouw, C A Seldenrijk, G J A Offerhaus, M Visser, F J Ten Kate, K Biermann, L A A Brosens, M Doukas, C Huysentruyt, A Karrenbeld, G Kats-Ugurlu, J S van der Laan, G van Lijnschoten, F C P Moll, A H A G Ooms, H van der Valk, J G Tijssen, J J Bergman, S L Meijer
AIMS: Interobserver agreement for dysplasia in Barrett's oesophagus (BO) is low and guidelines advise expert review of dysplastic cases. We assessed the added value of p53 immunohistochemistry (IHC) on the homogeneity within a group of dedicated gastro-intestinal (GI) pathologists. METHODS AND RESULTS: Sixty single hematoxylin & eosin (HE) slide referral BO cases (20 low-grade dysplasia (LGD); 20 high-grade dysplasia (HGD) and 20 non-dysplastic BO (NDBO) reference cases) were digitalised and independently assessed twice in a random order by 10 dedicated GI pathologists...
January 3, 2018: Histopathology
https://www.readbyqxmd.com/read/29297942/expression-pattern-of-immunosurveillance-related-antigen-in-adult-t-cell-leukemia-lymphoma
#9
Naoko Asano, Hiroaki Miyoshi, Takeharu Kato, Joji Shimono, Noriaki Yoshida, Daisuke Kurita, Yuya Sasaki, Keisuke Kawamoto, Koichi Ohshima, Masao Seto
AIMS: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with a poor prognosis. Human leukocyte antigen (HLA) and β2M serve as key molecules in tumor immunity, and their expression is frequently reduced in tumor cells. Programmed cell death (PD)-1/PD-ligand1 (PD-L1) interactions play a role in escape of tumor cells from T-cell immunity. Therefore, this study aimed to determine the clinicopathological relevance of HLA and β2M expressions in ATLL cells and PD-L1 expression in lymphoma or stromal cells and predict the overall survival of patients with ATLL...
January 3, 2018: Histopathology
https://www.readbyqxmd.com/read/29278427/gastric-pyloric-gland-adenoma-a-multicenter-clinicopathologic-study-of-67-cases
#10
Won-Tak Choi, Ian Brown, Tetsuo Ushiku, Masato Yozu, Namrata Setia, Amitabh Srivastava, Melanie Johncilla, Rish K Pai, Ryan M Gill, Masashi Fukayama, Joseph Misdraji, Gregory Y Lauwers
AIMS: There is limited information regarding the clinicopathologic and immunohistochemical characteristics of gastric pyloric gland adenomas (PGAs). METHODS AND RESULTS: Sixty seven cases of gastric PGA from 57 patients were analyzed. PGAs occurred with similar frequency in men and women (47.4% and 52.6%, respectively) with a mean age of 66 years. Most presented in the gastric body/fundus (67.2%). Fifteen cases (22.4%) developed in a background of autoimmune gastritis (AIG), whereas normal mucosa was seen in 35...
December 26, 2017: Histopathology
https://www.readbyqxmd.com/read/29274092/insulinoma-associated-protein-1-insm1-differentiates-carcinoid-tumorlets-of-the-lung-from-pulmonary-meningothelial-like-nodules
#11
LETTER
Josephine K Dermawan, Sanjay Mukhopadhyay
Insulinoma-associated protein 1 (INSM1) is a zinc-finger transcription factor isolated from pancreatic insulinoma tissue. This protein controls expression of a neuroendocrine phenotype and is responsible for transcription of synaptophysin and chromogranin. In recent years, it has emerged as a sensitive and specific immunohistochemical marker of neuroendocrine neoplasms, and is currently the only commercially available nuclear marker of neuroendocrine differentiation. This article is protected by copyright. All rights reserved...
December 23, 2017: Histopathology
https://www.readbyqxmd.com/read/29266325/hmga2-but-not-hmga1-is-overexpressed-in-human-larynx-carcinomas
#12
Antonio Palumbo, Marco De Martino, Francesco Esposito, Filippo Fraggetta, Pedro Nicolau Neto, Priscila Valverde Fernandes, Izabella Costa Santos, Fernando Luiz Dias, Luiz Eurico Nasciutti, Nathalia Meireles Da Costa, Alfredo Fusco, Luis Felipe Ribeiro Pinto
Malignant tumors from the upper aerodigestive tract are collectively grouped in the class of head and neck squamous cell carcinoma (HNSCC). The head and neck tumors were responsible for more than 500,000 cancer cases in 2012, accounting for the sixth highest incidence rate and mortality worldwide among all tumor types. Laryngeal squamous cell carcinoma (LSCC), possesses the second highest incidence rate among all HNSCC. Despite significant advances in surgery and radiotherapy over the last few decades, no treatment has been shown to achieve a satisfactory therapeutic outcome and the mortality rate of LSCC is still high, with a 5-year survival rate of 64%...
December 21, 2017: Histopathology
https://www.readbyqxmd.com/read/29265482/eosinophilic-solid-and-cystic-esc-renal-cell-carcinomas-have-metastatic-potential
#13
LETTER
Jesse K McKenney, Christopher Przybycin, Kiril Trpkov, Cristina Magi-Galluzzi
We read with great interest the study by Li et al. entitled "Re-evaluation of 33 "Unclassified" Eosinophilic Renal Cell Carcinomas in Young Patients", in which the authors describe the significant degree of histologic overlap between different subtypes of renal cell carcinomas (RCCs) with eosinophilic/oncocytic features occurring in young patients. This study highlights the fact that the prototypical pathologic features, particularly for FH-deficient and SDH-deficient RCCs, are often not as well-developed in younger patients, a finding also recently described by Smith et al...
December 19, 2017: Histopathology
https://www.readbyqxmd.com/read/29247494/podocyte-and-endothelial-cell-injury-develop-nephrotic-syndrome-in-proliferative-lupus-nephritis
#14
Aya Nawata, Satoshi Hisano, Shohei Shimajiri, Ke-Yong Wang, Yoshiya Tanaka, Toshiyuki Nakayama
AIMS: Nephrotic syndrome (NS) is a major manifestation of lupus nephritis (LN). The dysregulation of podocyte, glomerular basement membrane (GBM) and endothelial cell (EC) develops proteinuria in glomerular diseases. The aim of our study is to clarify whether the dysregulation of these barriers is associated with NS in proliferative LN and membranous LN. METHODS AND RESULTS: Fifty six patients with NS including minimal change NS in 15, primary membranous nephropathy (PMN) in 13, Class III/IV LN in 15 and Class V LN in 13 were enrolled in this study...
December 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29243296/role-of-conventional-immunomarkers-hnf4-a-and-satb2-in-the-differential-diagnosis-of-pulmonary-and-colorectal-adenocarcinomas
#15
Mark Kriegsmann, Alexander Harms, Rémi Longuespée, Thomas Muley, Hauke Winter, Katharina Kriegsmann, Daniel Kazdal, Benjamin Goeppert, Anita Pathil, Arne Warth
OBJECTIVE: Pulmonary (ADC) and colorectal (CRC) adenocarcinomas are frequent entities in pathological routine diagnostics. Whereas the differential diagnosis is usually straight forward based on histomorphology, it can be challenging in small biopsies. In general, CDX-2, CK20, Napsin-A, and TTF-1 are recommended immunohistological markers in this scenario. Hepatocyte nuclear factor 4 alpha (HNF4-a) and special AT-rich sequence-binding protein 2 (SATB2) were recently described as promising additional markers, but comprehensive large scale data are lacking so far...
December 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29235144/histological-assessment-of-the-liver-explant-in-transplanted-hcv-patients-achieving-sustained-virologic-response-with-direct-acting-antiviral-agents
#16
Juan Putra, Thomas D Schiano, M Isabel Fiel
AIMS: The use of direct-acting anti-viral agents (DAAs) has resulted in extremely high sustained virologic response (SVR) rates in patients being treated while on liver transplantation (LT) waiting lists. The aim of this study was to evaluate the histological findings of HCV patients who achieved SVR after receiving DAA treatment (SVR(+)) prior to LT and comparing them to HCV patients who had not achieved SVR (SVR(-)). METHODS AND RESULTS: Fifty-eight adult HCV patients who underwent LT at our institution from 2014-2016 were included in the study...
December 13, 2017: Histopathology
https://www.readbyqxmd.com/read/29220097/invasive-mucinous-carcinoma-of-the-breast-and-response-patterns-after-neoadjuvant-chemotherapy-nac
#17
Susan Fineberg, Rosemarie Didonato, Nella Shapiro, Tova Koenigsberg, Timothy D'Alfonso, Shabnam Jaffer
AIMS: Neoadjuvant chemotherapy (NAC) is often used to treat localized invasive breast cancer. Invasive mucinous carcinoma (IMC) is considered to be an indolent form of invasive breast cancer and is rarely treated with NAC. We report the largest series of IMC treated with NAC, and report a characteristic, but not well recognized, pattern of pathologic response. METHODS AND RESULTS: Our series included 7 patients with IMC treated with NAC. Three patients presented with locally advanced disease, three patients had tumors that were Her/2Neu positive, and four patients had tumors with admixed mucinous and micropapillary features...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29220096/hepatic-progenitor-cells-in-metastatic-liver-carcinomas
#18
Ioanna Delladetsima, Stratigoula Sakellariou, Olivier Govaere, Elpida Poulaki, Evangelos Felekouras, Dina Tiniakos
AIMS: Hepatic progenitor cells (HPCs) are activated in various liver diseases but their role in carcinomatous environment remains unknown. We aimed to identify the possible presence and topography of HPCs in liver metastases. METHODS: We examined 14 liver resection specimens for colorectal adenocarcinoma (CRC) (n=13) and anal squamous cell carcinoma (SCC) (n=1) metastases. Immunohistochemical markers of colonic (keratin 20-K20, CDX2) and squamous cell origin (p63), HPC (K19, CD56) and stem cell (CD44) markers, and the biliary marker K7 which may also highlight HPCs were applied on routinely processed tissue sections...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29220095/digital-image-analysis-of-ki67-in-hot-spots-is-superior-to-both-manual-ki67-and-mitotic-counts-in-breast-cancer
#19
Gustav Stålhammar, Stephanie Robertson, Lena Wedlund, Michael Lippert, Mattias Rantalainen, Jonas Bergh, Johan Hartman
AIMS: During pathological examination of breast tumours, proliferative activity is routinely evaluated by a count of mitoses. Adding immunohistochemical stains of Ki67 provides extra prognostic and predictive information. However, currently used methods for these evaluations suffer from imperfect reproducibility. It is still unclear whether analysis of Ki67 should be performed in hot spots, in the tumour periphery or as an average of the whole tumour section. In this paper, we compare the clinical relevance of mitoses, Ki67 and Phosphohistone H3 in two cohorts of primary breast cancer specimens (total n=294)...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29206290/primary-effusion-lymphoma-in-taiwan-shows-two-distinctive-clinicopathological-subtypes-with-rare-hiv-association
#20
Bo-Jung Chen, Ran-Ching Wang, Chung-Han Ho, Chang-Tsu Yuan, Wan-Ting Huang, Sheau-Fang Yang, Pin-Pen Hsieh, Yun-Chih Yung, Shih-Yao Lin, Chen-Fang Hsu, Ying-Zhen Su, Chun-Chi Kuo, Shih-Sung Chuang
AIMS: To investigate the clinicopatholoigcal and molecular features of primary effusion lymphoma (PEL) in Taiwan and the association with HIV, HHV8, and EBV. METHODS AND RESULTS: We retrospectively investigated 26 cases with a median age of 76.5. Only one (4%) patient was infected with HIV. Cytologically, all lymphoma cells revealed typical immunoblastic to plasmablastic morphology. Immunohistochemically, HHV8 was positive in 8 (32%) tumours, negative in 17 (68%) cases...
December 5, 2017: Histopathology
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