journal
MENU ▼
Read by QxMD icon Read
search

Histopathology

journal
https://www.readbyqxmd.com/read/28425135/image-editing-for-pathologists
#1
LETTER
Tim Helliwell
The correspondence from Driman and Schick (Histopathology 2017, 70, 840) provides useful guidance to contributors on how to optimise the quality of images in publications. As these authors note, care must be taken to avoid misrepresentation of the information provided in the image. Ethical guidance on the appropriate use and manipulation of digital images is available - see table (Cromey, 2010) and has been adopted by various print and online publications. This article is protected by copyright. All rights reserved...
April 20, 2017: Histopathology
https://www.readbyqxmd.com/read/28425130/histological-grading-based-on-poorly-differentiated-clusters-pdc-is-predictive-of-tumor-response-and-clinical-outcome-in-rectal-carcinoma-treated-with-neo-adjuvant-chemo-radiotherapy
#2
Luca Reggiani Bonetti, Simona Lionti, Federica Domati, Giuliana Pagliani, Elisabetta Mattioli, Valeria Barresi
AIMS: The clinical outcome of patients with locally advanced rectal cancer submitted to neo-adjuvant chemo-radiotherapy (CRT) is influenced by tumour response to treatment, which is reflected by tumour regression grade (TRG) and post-treatment (y) TNM stage. Little is known on the prognostic value of pre-treatment histopathological features of the tumour which may be useful to discriminate potential non-responders and to design tailored therapeutic strategies. In this study, we aimed to investigate the prognostic role of poorly differentiated clusters (PDC) of neoplastic cells in pre-treatment biopsies of rectal cancer submitted to neo-adjuvant CRT...
April 20, 2017: Histopathology
https://www.readbyqxmd.com/read/28418164/molecular-subtyping-of-mammary-like-adenocarcinoma-of-the-vulva-shows-molecular-similarity-to-breast-carcinomas
#3
Basile Tessier-Cloutier, Karama Asleh-Aburaya, Varsha Shah, W Glenn McCluggage, Anna Tinker, C Blake Gilks
AIMS: Mammary-like adenocarcinoma (MLA) of the vulva is thought to be derived from vulvar mammary-like glands. We characterized a series of MLA using an immunohistochemical algorithm that identifies the major molecular subtypes of breast cancer. METHODS AND RESULTS: Seven cases of vulval MLA were stained for ER, PR, HER2, Ki-67, EGFR, CK5, nestin and INPP4b. 17 cases of vulval extramammary Paget disease (EMPD), 7 with invasion, were studied for comparison. The median age of patients with MLA was 72 years...
April 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28417598/genetic-analysis-of-a-morphologically-heterogeneous-ovarian-endometrioid-carcinoma
#4
Felipe C Geyer, Fresia Pareja, Kathleen A Burke, Anne M Schultheis, Yaser R Hussein, Jiqing Ye, Maria R De Filippo, Caterina Marchio, Gabriel S Macedo, Salvatore Piscuoglio, Raymond S Lim, Eugene Toy, Rajmohan Murali, Achim A Jungbluth, Jorge S Reis-Filho, Robert A Soslow, Britta Weigelt
AIMS: Low-grade ovarian endometrioid carcinomas may be associated with high-grade components. Whether the latter are clonally-related to and originate from the low-grade endometrioid carcinoma remains unclear. Here we employed massively parallel sequencing to characterize the genomic landscape and clonal relatedness of an ovarian endometrioid carcinoma containing low- and high-grade components. METHODS AND RESULTS: DNA samples extracted from each tumor component (low-grade endometrioid, high-grade anaplastic, high-grade squamous) and matched normal tissue were subjected to targeted massively parallel sequencing using the 410 gene Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) sequencing assay...
April 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28419539/pd-l1-expression-in-extrahepatic-cholangiocarcinoma
#5
Dirk Walter, Eva Herrmann, Andreas Schnitzbauer, Stefan Zeuzem, Martin Leo Hansmann, Jan Peveling-Oberhag, Sylvia Hartmann
AIMS: To investigate expression of programmed cell death 1 (PD-1) receptor / programmed cell death ligand 1 (PD-L1) pathway as well as clinicopathological characteristics in extrahepatic cholangiocarcinoma (eCCA). METHODS: Tissue samples from patients with eCCA (n=69; perihilar CCA=40, distal CCA=29), who underwent surgical resection in the period from 2007 to 2015 were evaluated for PD-1, PD-L1, CD3 and CD163 expression and correlation with clinicopathological characteristics, including survival data, was performed...
April 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28407385/effect-of-formalin-fixation-and-tumor-size-in-small-sized-non-small-cell-lung-cancer-a-prospective-single-center-study
#6
Heae Surng Park, Sungsoo Lee, Seokjin Haam, Geun Dong Lee
AIM: Formalin fixation can cause tumor shrinkage. We prospectively evaluated the effect of overnight formalin fixation on tumor size and the effect of clinicopathological parameters on changes in tumor size in small-sized non-small cell lung cancer (NSCLC). METHODS AND RESULTS: Our study included 126 surgically resected NSCLC specimens submitted in a fresh state. We measured the largest cross-sectional tumor diameters in the fresh and formalin-fixed specimens. Tumor size significantly differed (mean, 0...
April 13, 2017: Histopathology
https://www.readbyqxmd.com/read/28401582/histological-features-of-malignancy-correlate-with-growth-patterns-and-patient-outcome-in-lung-adenocarcinoma
#7
Johanna M Mäkinen, Kirsi Laitakari, Shirley Johnson, Riitta Mäkitaro, Risto Bloigu, Paavo Pääkkö, Elisa Lappi-Blanco, Riitta Kaarteenaho
AIMS: Until the launch of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) adenocarcinoma classification in 2011, there were no uniform histological grading criteria for pulmonary adenocarcinomas. The current classification highlights the prognostic importance of the various histological growth patterns observed in these morphologically heterogeneous neoplasias. In this study, we aimed to evaluate the classic histological parameters of malignancy in correlation with the growth patterns and patient outcome in a series of 112 surgically operated stage I-IV lung adenocarcinomas...
April 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28394416/histopathological-characteristics-of-interstitial-cystitis-bladder-pain-syndrome-without-hunner-lesion
#8
Aram Kim, Ju-Young Han, Chae-Min Ryu, Hwan Yeul Yu, Seungun Lee, YongHwan Kim, Se Un Jeong, Yong Mee Cho, Dong-Myung Shin, Myung-Soo Choo
AIMS: We aimed to assess the distinct histopathological characteristics and their clinical significance between non-Hunner and Hunner interstitial cystitis/bladder pain syndrome(IC/BPS). METHODS AND RESULTS: We prospectively enrolled and classified IC/BPS patients, based on cystoscopic findings, as non-Hunner type IC and Hunner type IC. Specimens obtained from the posterior wall in non-Hunner type IC cases during hydrodistension or from Hunner /non-Hunner lesions in Hunner type IC cases during transurethral resection were evaluated...
April 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28394406/pbrm1-loss-is-a-late-event-during-the-development-of-cholangiocarcinoma
#9
Claudio Luchini, Scott A Robertson, Seung Mo Hong, Matthäus Felsenstein, Robert A Anders, Antonio Pea, Alessia Nottegar, Nicola Veronese, Jin He, Matthew J Weiss, Paola Capelli, Aldo Scarpa, Pedram Argani, Payal Kapur, Laura D Wood
Somatic mutations in genes encoding chromatin remodelers have been recently reported in several cancer types, including approximately half of cholangiocarcinomas. One of the most commonly mutated chromatin remodelers in cholangiocarcinoma is the PBRM1 gene located on chromosome 3p21, which encodes a subunit of the SWI/SNF complex. In order to determine the timing of PBRM1 mutations in biliary carcinogenesis, we used immunohistochemistry to assess PBRM1 protein expression in a series of precursor lesions and invasive biliary carcinomas...
April 10, 2017: Histopathology
https://www.readbyqxmd.com/read/28387954/immune-modulator-induced-changes-in-the-gastrointestinal-tract-reply
#10
Raul S Gonzalez, Safia N Salaria, Caitlin D Bohannon, Aaron R Huber, Michael M Feely, Chanjuan Shi
We thank Bavi et al for their response to our article, which includes a series of 34 gastrointestinal biopsies from 21 patients taking a PD-1 or PD-L1 inhibitor. It is not surprising that a sizable minority of their colon cases demonstrated increased intraepithelial lymphocytes; indeed, we considered it somewhat unusual that our cohort generally did not express this finding, given that CTLA-4 inhibitors commonly induce this pattern of injury in humans. Since publication of our series, we have learned of several additional cases of PD-1 inhibitor colitis, some from the literature(1) and others from lecture presentations...
April 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28383817/cd70-and-pdl1-in-anaplastic-thyroid-cancer-ndash-promising-targets-for-immunotherapy
#11
Karen Zwaenepoel, Julie Jacobs, Astrid De Meulenaere, Karen Silence, Evelien Smits, Vasiliki Siozopoulou, Esther Hauben, Christian Rolfo, Sylvie Rottey, Patrick Pauwels
AIMS: Over the last years, immune checkpoint inhibition has proven to be effective in several solid malignancies. The aim of this study was to identify novel targets for immunotherapy in anaplastic thyroid cancer by analysis of the expression of tumor antigens for which therapeutic agents are available. METHOD AND RESULTS: By immunohistochemistry we observed tumoral expression of CD70 in 49% of cases. Expression of its receptor, CD27 was mainly present in lymphocytes surrounding and infiltrating the tumor and only rarely observed in tumor cells...
April 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28383794/secretory-breast-carcinoma-with-a-papillary-predominant-pattern-an-uncommon-morphology-variant
#12
Ruohong Shui, Yufan Cheng, Qianming Bai, Wentao Yang
AIMS: Secretory breast carcinoma is a rare, low-grade, translocation-associated invasive carcinoma with unique morphology and excellent prognosis. Three patterns (microcystic, tubular, solid) have often been described in secretory carcinoma. Herein, we reported one case of secretory breast carcinoma with uncommon papillary predominant growth pattern. METHODS AND RESULTS: The patient was a 53-year-old female with a mass located in outer upper quadrant of her right breast...
April 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28383777/the-pd-1-expressing-immune-phenotype-of-t-cell-exhaustion-is-prominent-in-the-immunoreactive-microenvironment-of-colorectal-carcinoma
#13
Friedrich Prall, Maja Hühns
AIMS: This study was designed to test PD-1 expression of T cells, the hallmark of T cell exhaustion, in different "immune-classes" of colorectal carcinoma microenvironments as delineated by unsupervised hierarchical cluster analysis. METHODS AND RESULTS: A tissue microarray was made with punches from the invasive margins of 40 microsatellite unstable and 34 microsatellite stable colorectal carcinomas. Immune cells were phenotyped by CD8, granzyme B, CD4, FoxP3, CD68, S-100, PD-1, and PD-L1 immunohistochemistry; tumour area per tissue spot was quantified by CK18 immunohistochemistry...
April 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28374498/utility-of-gata3-in-the-differential-diagnosis-of-pheochromocytoma
#14
Carmen M Perrino, Alex Ho, Christopher P Dall, Debra L Zynger
AIMS: GATA3 is a relatively new immunohistochemical marker which shows consistent nuclear expression in a variety of tumors, including breast and urothelial carcinoma. The staining pattern of GATA3 in adrenal lesions is not well established. We aim to describe the expression of GATA3 in adrenal tumors and determine if there is differential staining between pheochromocytoma and adrenal cortical carcinoma. METHODS AND RESULTS: A retrospective search was performed to identify 74 adrenal lesions which were immunohistochemically tested for GATA3 expression...
April 4, 2017: Histopathology
https://www.readbyqxmd.com/read/28370248/the-pathology-and-causes-of-tissue-eosinophilia-in-the-gastrointestinal-tract
#15
REVIEW
James R Conner, Richard Kirsch
Eosinophilic inflammation in the gastrointestinal tract may occur as a primary eosinophilic disorder or as a secondary response to other causes. Primary eosinophilic gastrointestinal disorders (EGIDs) are Th-2 mediated allergic diseases that overlap pathogenetically with atopic conditions involving other organs. Pathologic diagnosis of primary EGIDs can be challenging since the quantity of eosinophils considered "abnormal" is difficult to define, and the diagnosis, by definition, requires exclusion of the far more common secondary causes...
March 31, 2017: Histopathology
https://www.readbyqxmd.com/read/28370249/possible-role-of-nuclear-%C3%AE-catenin-in-resistance-to-preoperative-chemoradiotherapy-in-locally-advanced-rectal-cancer
#16
Hiroyuki Takahashi, Kie Nakamura, Akane Usami, Tomoko Tsuruta, Miki Hashimura, Toshihide Matsumoto, Makoto Saegusa
AIMS: β-catenin signaling participates in regulation of epithelial-mesenchymal transition (EMT)/cancer stem cell (CSC) properties. We focused on the role of β-catenin in resistance to neoadjuvant chemoradiotherapy in patients with rectal cancer especially pertaining to its association with EMT/CSC features. METHODS AND RESULTS: A total of 109 cases of locally advanced rectal cancer, along with a colon cancer cell line, were investigated. Nuclear β-catenin accumulation in pretreatment biopsied samples was inversely associated with therapeutic efficacy for chemoradiotherapy in resected rectal cancer...
March 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28370175/expression-of-cancer-testis-antigens-in-salivary-gland-carcinomas-with-reference-to-mage-a-and-ny-eso-1-expression-in-adenoid-cystic-carcinoma
#17
Shintaro Beppu, Yohei Ito, Kana Fujii, Kousuke Saida, Hisashi Takino, Ayako Masaki, Takayuki Murase, Kimihide Kusafuka, Yoshiyuki Iida, Tetsuro Onitsuka, Yasushi Yatabe, Nobuhiro Hanai, Yasuhisa Hasegawa, Kei Ijichi, Shingo Murakami, Hiroshi Inagaki
BACKGROUND: Salivary gland carcinomas comprise a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biological behaviors. However, recurrent or metastatic tumors are difficult to treat with currently available therapies. Cancer-testis antigens (CTAs) are detected in cancer cells but not in healthy normal tissues, with the exception of gametogenic tissues. CTAs are highly immunogenic proteins and thus represent ideal targets for cytotoxic T-lymphocyte-mediated specific immune therapy...
March 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28342232/immune-modulator-induced-changes-in-the-gastrointestinal-tract
#18
LETTER
Prashant Bavi, Marcus Butler, Stefano Serra, Runjan Chetty
We read with interest the article by Gonzalez et al (1)  wherein they describe meticulously the spectrum of changes in series of gastrointestinal (GI) biopsies in patients treated with immune checkpoint inhibitors targeting Programmed cell death protein-1 (PD-1). With the demonstrated success of immune checkpoint blockade monoclonal antibodies, such as PD-1/PD-L1, resulting in both tumour response and durable remission in melanoma and non- small cell lung carcinoma(2) , it is expected that their use will expanded to other tumours...
March 25, 2017: Histopathology
https://www.readbyqxmd.com/read/28342221/p53-immunohistochemistry-in-high-grade-urothelial-carcinoma-of-the-bladder-is-prognostically-significant
#19
Anjelica Hodgson, Bin Xu, Michelle R Downes
AIMS: TP53 mutations are characteristic of the high grade pathway in the dual pathway of urothelial carcinogenesis. These mutations have been correlated with aberrant accumulation of p53 protein, however the definition and significance of this varies in the literature. We assessed p53 immunostaining in a cohort of high grade urothelial carcinomas using standard published cut offs and a novel binarized method which included assessment of the null phenotype. Each scoring method was correlated with oncologic outcome...
March 25, 2017: Histopathology
https://www.readbyqxmd.com/read/28342197/clinicopathological-analysis-of-primary-central-nervous-system-nk-t-cell-lymphoma-rare-and-localised-aggressive-tumour-among-extranasal-nk-t-cell-tumours
#20
Tomoko Miyata-Takata, Katsuyoshi Takata, Seiichi Kato, Lei-Ming Hu, Mai Noujima-Harada, Shih-Sung Chuang, Yasuharu Sato, Yoshinobu Maeda, Tadashi Yoshino
AIMS: The central nervous system (CNS) is a rare primary site of non-Hodgkin lymphoma. Although direct invasion of nasal NK/T-cell tumours into CNS is occasionally reported, primary CNS NK/T-cell lymphoma is extremely rare, and the clinicopathological features of primary CNS NK/T-cell lymphoma remain largely unknown. METHODS AND RESULTS: We identified four cases from our consultation files and analysed the clinicopathological features. Three were immunocompetent (IC) and one was immunosuppressive patient...
March 25, 2017: Histopathology
journal
journal
20117
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"