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Nicola Fusco, Arturo Bonometti, Claudia Augello, Sonia Fabris, Leonardo Boiocchi, Stefano Fiori, Denise Morotti, Nicola Fracchiolla, Emilio Berti, Umberto Gianelli
AIMS: The aims of this study were to define whether diffuse cutaneous reticulohistiocytosis could be underpinned by somatic genetic alterations and represent precursor to more aggressive forms of disease. METHODS AND RESULTS: A 59-year-old man with diffuse cutaneous reticulohistiocytosis, experienced bone marrow localisation of the disease, with associated systemic mastocytosis and acute myeloid leukaemia. Cytogenetic analyses of the bone marrow aspirate revealed the presence of a derivative chromosome giving rise to a partial trisomy of chromosome 1q and a partial monosomy of chromosome 9q...
January 11, 2017: Histopathology
Nicola Fusco, Elena Guerini-Rocco, Claudia Augello, Andrea Terrasi, Giulia Ercoli, Caterina Fumagalli, Davide Vacirca, Paola Braidotti, Antonina Parafioriti, Marta Jaconi, Letterio Runza, Vijayalakshmi Ananthanarayanan, Fabio Pagni, Silvano Bosari, Massimo Barberis, Stefano Ferrero
AIMS: Pulmonary adenofibromas are rare benign fibroepithelial tumours of the lung with unknown histogenesis and an indolent clinical behaviour. Their stroma resembles that of solitary fibrous tumours, while the glands are composed of respiratory epithelium organized in a phyllodes-like architecture. Differentiation of pulmonary adenofibromas from other more aggressive intrathoracic tumours is clinically relevant. However, their biology is unknown. Here, we sought to characterize pulmonary adenofibromas at a clinicopathologic level and to define whether they could be underpinned by a highly recurrent somatic genetic alteration akin to tumours with similar morphology...
January 10, 2017: Histopathology
Gregor Rieger, Viktor H Koelzer, Heather E Dawson, Martin D Berger, Marion Hädrich, Daniel Inderbitzin, Alessandro Lugli, Inti Zlobec
BACKGROUND: Tumour budding in colorectal cancer (CRC) is a recognized prognostic parameter. Aim of this study is to address the use of cytokeratin immunostaining for visualization and scoring of tumour buds. METHODS: Ten hotspots (0.238 mm(2) ) of peritumoural (PTB) and intratumoural (ITB) budding were evaluated in surgical resections from 215 patients. The budding counts in the 10 densest regions anywhere in the tumour were combined into an overall tumour budding (OTB) score...
January 6, 2017: Histopathology
Jennifer Chapman, Francisco Vega
The patient is a 54 year-old male with HIV diagnosed in 1992 who has been on HAART therapy with well controlled disease, no opportunistic infections, CD4 count >1000 cells / mm(3) with an undetectable viral load. He noticed a painless growing mass in his left parotid gland. The patient denied weight loss, fever and night sweats. Lymphadenopathy was not appreciated. CT-scan showed an enhancing lesion in the left parotid which was surgically excised. This article is protected by copyright. All rights reserved...
January 2, 2017: Histopathology
S Andreasen, J Bishop, T V O Hansen, W H Westra, A Bilde, C von Buchwald, K Kiss
AIMS: Human Papillomavirus (HPV) is known as causative for squamous cell carcinoma (SCC) of the oropharynx, but is also not infrequently found in carcinomas of the sinonasal tract. Recently, a subset of these carcinomas was recognized to harbour HPV33 and have a significant morphological overlap with adenoid cystic carcinoma (ACC), a rare and aggressive carcinoma originating in the minor salivary glands. Termed HPV-related carcinoma with ACC-like features, only 9 cases have been reported...
December 30, 2016: Histopathology
Gillian Charlotte Bethune, Alexandra Sophie Louise Pettit, Daniel Veldhuijzen van Zanten, Penelope Jane Barnes
AIMS: The 2013 ASCO/CAP HER2 guidelines recommend testing all invasive breast cancers for HER2, typically with IHC followed by ISH when IHC is equivocal. As well-differentiated breast cancers are rarely HER2 positive, we assessed the value of routine reflex HER2 ISH testing for this subset of breast cancers. METHODS AND RESULTS: We collected HER2 IHC 2+ cases and FISH data from primary breast cancers with well-differentiated tumor types (grade 1 ductal carcinomas, classic lobular carcinomas, tubular, cribriform and pure mucinous carcinomas) at our centre from 2010-2015...
December 29, 2016: Histopathology
Wen-Yu Chuang, Hung Chang, Gwo-Jyh Chang, Tzu-Hao Wang, Yu-Sun Chang, Tong-Hong Wang, Chi-Ju Yeh, Shir-Hwa Ueng, Hui-Ping Chien, Chiu-Yueh Chang, Yung-Liang Wan, Chuen Hsueh
AIMS: To characterize the clinicopathologic and genetic features of pleomorphic mantle cell lymphoma (PMCL) which morphologically mimics diffuse large B-cell lymphoma (DLBCL). METHODS AND RESULTS: We systematically screened 500 B-cell lymphomas morphologically compatible with DLBCL using an immunohistochemical algorithm of three markers (CD5, cyclin D1 and SOX11). Ten cases of PMCL were identified for further study, and surprisingly four (40%) of them were cyclin D1-negative...
December 29, 2016: Histopathology
Emad A Rakha, Nuno D M Coimbra, Zsolt Hodi, Enaam Juneinah, Ian O Ellis, Andrew H S Lee
BACKGROUND: Metaplastic breast carcinoma (MBC) is a rare type of breast cancer and its diagnosis in routine practice can be challenging and may require immunohistochemical (IHC) characterisation if no conventional invasive or in situ carcinoma is present. Previous IHC studies of MBC often had a small sample size and did not investigate the different histological subtypes. This study aimed to assess the immunoprofile of MBC subtypes in a large series. METHODS: 172 MBC diagnosed in routine and referral practice in Nottingham over 26 years were reviewed by 3 breast pathologists...
December 28, 2016: Histopathology
Nina Zidar, Cord Langner, Katarina Odar, Lea Hošnjak, Kateřina Kamarádová, Ondrej Daum, Marion J Pollheimer, Pavle Košorok, Mario Poljak
AIMS: Verrucous carcinoma (VC) is a variant of well differentiated squamous cell carcinoma and is in the anal region regarded as synonymous with giant condyloma (Buschke-Löwenstein tumor) (BLT). Etiology, diagnostic criteria and clinical behavior of both lesions are controversial. Recent studies suggest that VC at other sites is not associated with human papillomaviruses (HPV). We hypothesized that anal VC is also not related to HPV, while BLT is a HPV-induced lesion. METHODS AND RESULTS: Ten cases of VC and 4 cases of BLT were included...
December 24, 2016: Histopathology
Steven Johnson, Stephanie Mathews, David S Hudnall
AIMS: Lymphadenopathy, hematologic abnormalities, and constitutional symptoms are among the non-specific manifestations seen in drug rash with eosinophilia and systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse drug reaction. The ubiquitous human herpesvirus 6 (HHV-6) plays a unique role in the pathogenesis of DRESS, with emerging data suggesting that reactivation occurs in most cases and contributes to the clinical manifestations, including lymphadenopathy...
December 23, 2016: Histopathology
Chang-Tsu Yuan, Wen-Chih Huang, Cheng-Han Lee, Ming-Chieh Lin, Chen-Hui Lee, Yu-Chien Kao, Hsuan-Ying Huang, Kuan-Ting Kuo, Jen-Chieh Lee
BACKGROUND: MED12 exon 2 mutations have been identified in most uterine leiomyomas and mammary fibroepithelial tumors. MED12 has not been genotyped in most other gynecological mesenchymal tumors. DESIGN: 68 uncommon gynecological mesenchymal tumors were genotyped for MED12 exon 2, including 27 müllerian adenosarcomas (including 3 tentatively diagnosed as "variant adenosarcomas"), 6 cellular angiofibromas, 6 aggressive angiomyxomas, 5 angiomyofibroblastomas, 5 superficial myofibroblastomas, 5 atypical polypoid adenomyomas, and 14 endometrial stromal sarcomas...
December 21, 2016: Histopathology
Joep E G IJspeert, Ariana Madani, Lucy I H Overbeek, Evelien Dekker, Iris D Nagtegaal
BACKGROUND: Distinguishing premalignant sessile serrated lesions (SSL) from hyperplastic polyps (HP) is difficult for pathologists in daily practice. We aimed to evaluate nationwide variability within histopathology laboratories in the frequency of diagnosing SSL as compared to HP within the Dutch population based screening program for colorectal cancer (CRC) and to assess the effect of an e-learning module on interlaboratory consistency. METHODS: Data were retrieved from the Dutch Pathology Registry (PALGA) from start of the nationwide population screening program, January 2014, until December 2015...
December 21, 2016: Histopathology
Gauri Panse, Cheuk Hong Leung, Davis Ingram, Khalida Wani, Keila E Torres, Heather Lin, Alexander Lazar, Wei-Lien Wang
AIMS: STAT3 is a pro-oncogenic transcription factor that requires phosphorylation for transcriptional activation. We evaluated the role of pSTAT3 expression in neurofibromas, schwannomas and malignant peripheral nerve sheath tumors (MPNSTs). METHODS AND RESULTS: 26 neurofibromas, 62 schwannomas and 39 MPNSTs from a formalin-fixed paraffin-embedded tissue microarray were examined. Immunohistochemical analysis was performed using an anti-p-STAT3 (Tyr705) antibody...
December 19, 2016: Histopathology
Nobuyasu Awano, Minoru Inomata, Soichiro Ikushima, Daisuke Yamada, Masatoshi Hotta, Shunji Tsukuda, Toshio Kumasaka, Tamiko Takemura, Yoshinobu Eishi
AIMS: To evaluate pulmonary vasculopathy in an autopsy series of patients with combined pulmonary fibrosis and emphysema (CPFE) and compare these findings with those of patients with idiopathic pulmonary fibrosis (IPF) alone and emphysema alone. METHODS AND RESULTS: We retrospectively analysed the clinical, radiological, and pathological features of 26 patients with CPFE, 11 with IPF, and 23 with emphysema. We evaluated pulmonary vascular, venous-venular, and arteriolar tissue changes in the fibrotic, emphysematous, and relatively unaffected (preserved) areas by the Heath-Edwards scoring system...
December 19, 2016: Histopathology
Murali Varma, Lars Egevad, Brett Delahunt, Glen Kristiansen
We thank Drs Khani and Epstein(1) for their interest in our commentary on intraductal carcinoma of the prostate (IDC-P) and welcome the opportunity to further discuss this controversial issue of whether IDC-P should be graded, particularly in needle biopsies.(2) While we agree that pure IDC-P (lacking an invasive component) should not be graded to avoid confusion among clinicians, it is our considered opinion that IDC-P component associated with invasive carcinoma should be graded. This article is protected by copyright...
December 19, 2016: Histopathology
Raul S Gonzalez, Volkan Adsay, Rondell P Graham, Stuti G Shroff, Michael M Feely, Michael G Drage, David N Lewin, Eric A Swanson, Rhonda K Yantiss, Pelin Bağci, Alyssa M Krasinskas
AIMS: Massive gastric polyposis is a rare entity often associated with juvenile polyposis syndrome (JPS). We evaluated the clinicopathologic features of 22 patients with abundant gastric juvenile-type or hyperplastic-like polyps. METHODS AND RESULTS: The study included 12 males and 10 females with a median age of 48 years (range: 13-79). Fourteen (64%) patients carried a diagnosis of JPS, and three had prior gastrointestinal adenocarcinomas. Patients without known JPS presented at an older median age (60 versus 40 years; P=0...
December 19, 2016: Histopathology
B G Skov, P Clementsen, K R Larsen, J B Sørensen, A Mellemgaard
AIMS: To assess the prevalence of EML4-ALK rearrangement gene measured by immunohistochemistry in an unselected population-based consecutive cohort of patients with adenocarcinoma of the lung (ACL), and the correlation with smoking history, TTF1, gender, and age. METHODS AND RESULTS: All patients diagnosed in the population of the greater Copenhagen area were included, irrespective of gender, age, smoking habits, stage, or type of available diagnostic material. Tumours were stained with immunohistochemistry (clone 5A4)...
December 10, 2016: Histopathology
D M Parham, S E Pinder
Breast cancer is the most commonly diagnosed malignancy in women and with the advent of programmatic mammographic screening the proportion presenting as ductal carcinoma in situ (DCIS) now represents 20-30% of all breast carcinomas diagnosed(1) . The natural history of DCIS is unclear with few studies documenting its evolution. It is recognised to be a non-obligate precursor of invasive breast cancer and in one study 36% of women with low grade DCIS on biopsy progressed to invasive breast cancer up to 42 years after missed diagnosis...
December 10, 2016: Histopathology
Francesca Khani, Jonathan I Epstein
In Varma M et al.'s recently published commentary, "Reporting intraductal carcinoma of the prostate: A plea for greater standardization," the authors provide an overview of intraductal carcinoma of the prostate (IDC-P) and discuss the problematic issues pathologists may encounter in reporting this diagnosis.(1) While the 2016 World Health Organization (WHO) now defines IDC-P as a distinct entity and provides specific histologic criteria for diagnosis, efforts to further reduce the interobserver variability by diminishing any ambiguity that remains by further clarification of the current definition are sensible...
December 10, 2016: Histopathology
Katsutoshi Hirose, Masaya Okura, Sunao Sato, Shumei Murakami, Jyun-Ichiro Ikeda, Yuri Noda, Yasuo Fukuda, Eiichi Morii, Satoru Toyosawa
Osteosarcoma (OS) is the most common non-hemopoietic primary malignant bone tumour in which the neoplastic cells produce bone.(1) Conventional OS is the most frequent subtype of OS, and is further subdivided into osteoblastic, chondroblastic, fibroblastic, and giant cell-rich variants.(1) The gnathic OS exhibits a prominent chondroblastic component and has a high percentage of low-grade OS. This article is protected by copyright. All rights reserved.
December 7, 2016: Histopathology
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