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Histopathology

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https://www.readbyqxmd.com/read/29156101/primary-extra-axial-para-articular-chordoma-of-the-knee-a-case-report-and-the-review-of-literatur%C3%A4
#1
LETTER
Paweł Kurzawa, Magdalena Fundowicz, Michał Dopierała, Ana B Larque, G Petur Nielsen
Chordoma is a rare malignant tumor demonstrating notochordal differentiation [1]. It almost invariably arises in the axial skeleton however rare examples of primary extra-axial chordomas have been reported [2-5]. We describe herein, for the first time, a primary conventional chordoma arising in the synovium of the knee joint. This article is protected by copyright. All rights reserved.
November 20, 2017: Histopathology
https://www.readbyqxmd.com/read/29148086/novel-gene-fusion-of-prcc-mitf-defines-a-new-member-of-mit-family-translocation-renal-cell-carcinoma-clinicopathologic-analysis-and-detection-of-the-gene-fusion-by-rna-sequencing-and-fish
#2
Qiu-Yuan Xia, Xiao-Tong Wang, Sheng-Bing Ye, Xuan Wang, Rui Li, Shan-Shan Shi, Ru Fang, Ru-Song Zhang, Heng-Hui Ma, Zhen-Feng Lu, Qin Shen, Wei Bao, Xiao-Jun Zhou, Qiu Rao
AIMS: MITF, TFE3, TFEB and TFEC belong to the same microphthalmia-associated transcription factor family (MiT). Two transcription factors in this family have been identified in two unusual types of renal cell carcinoma (RCC): Xp11 translocation RCC harboring TFE3 gene fusions and t(6;11) RCC harboring a MALAT1-TFEB gene fusion. The 2016 World Health Organization classification of renal neoplasia grouped these two neoplasms together under the category of MiT family translocation RCC. RCCs associated with the other two MiT family members, MITF and TFEC, have rarely been reported...
November 17, 2017: Histopathology
https://www.readbyqxmd.com/read/29144557/penile-warty-mucoepidermoid-carcinoma-with-features-of-stratified-mucin-producing-intraepithelial-lesion-and-invasive-stratified-mucin-producing-carcinoma
#3
Kenji Yorita, Naoto Kuroda, Takushi Naroda, Masato Tamura, Chisato Ohe, Mukul Divatia, Mahul B Amin, Antonio L Cubilla, Dimitry V Kazakov, Ondrej Hes, Michael Michal, Michal Michal
AIMS: Stratified mucin-producing intraepithelial lesion (SMILE) and invasive stratified mucin-producing carcinoma (ISMC) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE/ISMC features. METHODS AND RESULTS: A 62-year-old Japanese man had a glans penis lesion of one and a half years duration, suggesting malignancy. Partial penectomy and left inguinal lymphadenectomy were performed...
November 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29143432/primary-myxoid-mesenchymal-tumor-with-intracranial-location-report-of-a-case-with-a-ewsr1-atf1-fusion
#4
LETTER
Raf Sciot, Sandra Jacobs, Frank Van Calenbergh, Philippe Demaerel, Agnieszka Wozniak, Maria Debiec-Rychter
About a third of soft tissue tumors are recognized by gene fusions. Some of these fusions are not histotype specific and occur in entities with totally different clinicopathological features. A good example is the fusion between EWSR1 and genes of the CREB transcription factor gene family (CREB1 or ATF1). This article is protected by copyright. All rights reserved.
November 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29143365/epigenetic-down-regulation-of-sox2-is-an-independent-poor-prognostic-factor-for-hypopharyngeal-cancers
#5
Mehmet Ozgur Avincsal, Naoe Jimbo, Kohei Fujikura, Hirotaka Shinomiya, Naoki Otsuki, Koichi Morimoto, Tatsuya Furukawa, Naruhiko Morita, Ritsuko Maehara, Tomoo Itoh, Ken-Ichi Nibu, Yoh Zen
AIMS: We recently reported that a small subset (7%) of oesophageal squamous cell carcinomas completely lacking SOX2 expression had unique clinicopathological features and a dismal prognosis. The present study aimed to elucidate whether the findings obtained in oesophageal cancers are applicable to hypopharyngeal or oropharyngeal squamous cell carcinomas (HPSCCs or OPSCCs, respectively). METHODS AND RESULTS: The study cohort consisted of consecutive patients with HPSCC (n=130) and OPSCC (n=65) who underwent surgery without preoperative therapy...
November 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29143359/indolent-t-lymphoblastic-proliferation-concomitant-to-acinic-cell-carcinoma-mimicking-t-lymphoblastic-lymphoma-case-report-and-literature-review
#6
Hajime Yasuda, Miyuki Tsutsui, Yasunori Ota, Masaru Tanaka, Norio Komatsu
Indolent T-lymphoblastic proliferation (iT-LBP) is a non-clonal benign condition showing extrathymic proliferation of T-lymphoblasts positive for CD3, CD4, CD8, and TdT. Isolated iT-LBP has been observed, but the majority of iT-LBP have been seen in conjunction with other disorders including Castleman disease, hepatocellular carcinoma, follicular dendritic cell tumors, angioimmunoblastic T-cell lymphoma, myasthenia gravis, and acinic cell carcinoma (ACC). The clinical course of iT-LBP is indolent, and no therapy is usually required...
November 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29119638/biphasic-papillary-renal-cell-carcinoma-is-a-rare-morphologic-variant-with-frequent-multifocality-a-study-of-28-cases
#7
Kiril Trpkov, Daniel Athanazio, Cristina Magi-Galluzzi, Helene Yilmaz, David Clouston, Abbas Agaimy, Sean R Williamson, Fadi Brimo, Jose I Lopez, Monika Ulamec, Nathalie Rioux-Leclercq, Maysoun Kassem, Nilesh Gupta, Arndt Hartmann, Xavier Leroy, Samir Al Bashir, Asli Yilmaz, Ondřej Hes
AIMS: To further characterize biphasic squamoid renal cell carcinoma (RCC), a recently proposed variant of papillary RCC. METHODS AND RESULTS: We identified 28 tumors from multiple institutions. They typically demonstrated two cell populations - larger cells with eosinophilic cytoplasm and higher-grade nuclei, surrounded by smaller, amphophilic cells with scanty cytoplasm. The dual morphology was variable (median 72.5% of tumor, range 5-100%); emperipolesis was found in all cases...
November 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29119584/concordance-in-braf-v600e%C3%A2-status-over-time-in-malignant-melanoma-and-corresponding-metastases
#8
Line Bjerrehave Nielsen, Nina Dabrosin, Karen Sloth, Marie Louise Bønnelykke-Behrndtz, Torben Steiniche, Johanne Lade-Keller
AIMS: The present study analysed the usability of an immunohistochemical (IHC) analysis compared to a frequently used mutation detection analysis and examined the extent of intra- and inter-tumour heterogeneity of BRAF V600E in primary tumours and their corresponding metastases. In the development of inter-tumour heterogeneity between the primary tumour and the corresponding metastases, time as a factor was also investigated. METHODS: In total, 227 samples from 224 melanoma patients were analysed using both the Cobas(®) 4800 BRAF V600 Mutation test and IHC anti-BRAF V600E staining...
November 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29106748/solitary-fibrous-tumor-of-the-female-genital-tract-a-clinicopathologic-analysis-of-25-cases
#9
Eric J Yang, Brooke E Howitt, Christopher Dm Fletcher, Marisa R Nucci
AIMS: Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of fibroblastic origin, first described as a tumor of the pleura and now well established at extrapleural sites. However, SFT in the female genital tract is rare and therefore not fully characterized. MATERIAL AND RESULTS: We describe a series of 25 SFTs arising throughout the gynecologic tract, including vulva (14 cases), vagina (1), cervix (1), uterus (6), ovary (2) and fallopian tube (1)...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29106744/germ-cell-tumor-growth-patterns-originating-from-clear-cell-carcinomas-of-the-ovary-and-endometrium-a-comparative-immunohistochemical-study-favouring-their-origin-from-somatic-stem-cells
#10
F F Nogales, J Prat, M Schuldt, N Cruz-Viruel, B Kau, E D'Angelo, X Matias-Guiu, A Vidal, W G McCluggage, J W Oosterhuis
AIMS: To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical and demonstrate a putative stem cell population. METHODS AND RESULTS: The clear cell tumours included 11 clear cell carcinomas (CCC) and 1 borderline clear cell tumour, while the GCT always included glandular yolk sac tumour (YST). In 4 cases, there were also foci of teratoma with immature neuroepithelial and endodermal tissues, and undifferentiated areas showing true embryoids...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29105175/the-world-health-organization-2016-classification-of-penile-carcinomas-a-review-and-update-from-the-international-society-of-urological-pathology-expert-driven-recommendations
#11
Antonio L Cubilla, Elsa F Velazquez, Mahul B Amin, Jonathan Epstein, Daniel M Berney, Cathy M Corbishley
The International Society of Urological Pathology (ISUP) held an expert driven penile cancer conference in Boston in March 2015 which focused on the new WHO classification of penile cancer: HPV-related tumors and histological grading. The conference was preceded by an online survey of the International Society of Urological Pathology members and the results were used to initiate discussions. Because of the rarity of penile tumors, this was not a consensus but an expert driven conference aiming to assist pathologists who do not see these tumor on a regular basis...
November 3, 2017: Histopathology
https://www.readbyqxmd.com/read/29105119/lymphoproliferative-disorders-with-concurrent-hhv8-and-ebv-infection-beyond-primary-effusion-lymphoma-and-germinotropic-lymphoproliferative-disorder
#12
Wei Wang, Rashmi Kanagal-Shamanna, Jeffrey L Medeiros
AIMS: Lymphoproliferative disorders (LPD) characterized by human herpesvirus 8 (HHV8) and Epstein-Barr virus (EBV) infection are rare and two entities are included in the World and Health Organization classification: primary effusion lymphoma (PEL) and germinotropic LPD. These two entities have very different clinicopathological presentations and prognosis. Here we describe two cases of HHV8-positive, EBV-positive lymphoma with clinicopathological features that are not consistent with either PEL or germinotropic LPD...
November 3, 2017: Histopathology
https://www.readbyqxmd.com/read/29094386/characteristics-and-outcome-of-prostate-cancer-patients-with-overall-biopsy-gleason-score-3-4-7-and-highest-gleason-score-3-4-7-or-3-4-7
#13
Esther I Verhoef, Charlotte F Kweldam, Intan P Kümmerlin, Daan Nieboer, Chris H Bangma, Luca Incrocci, Theodorus H van der Kwast, Monique J Roobol, Geert J van Leenders
AIM: Prostate cancer heterogeneity and multifocality might result in different Gleason scores (GS) at individual biopsy cores. According to WHO/ISUP guidelines, the GS in each biopsy core should be recorded with optional reporting of overall GS for the entire case. We aimed to compare the clinicopathologic characteristics and outcome of men with overall biopsy GS 3+4=7 with highest GS 3+4=7 (HI=OV) to those with highest GS > 3+4=7 (HI>OV). METHODS AND RESULTS: Prostate cancer biopsies from the European Randomized Study of Screening for Prostate Cancer (ERSPC) were revised according to WHO/ISUP 2014 guidelines (n=1031)...
November 1, 2017: Histopathology
https://www.readbyqxmd.com/read/29077232/insulin-like-growth-factor-ii-messenger-rna-binding-protein-3-is-an-independent-prognostic-factor-in-uterine-leiomyosarcoma
#14
Nobuko Yasutake, Yoshihiro Ohishi, Kenichi Taguchi, Yuka Hiraki, Masafumi Oya, Yumi Oshiro, Mari Mine, Takeshi Iwasaki, Hidetaka Yamamoto, Kenichi Kohashi, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda
AIMS: We aimed to identify the prognostic factors of uterine leiomyosarcoma (ULMS). METHODS AND RESULTS: We reviewed 6160 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expressions of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. In addition, mediator complex subunit 12 (MED12) mutation analysis was also performed...
October 27, 2017: Histopathology
https://www.readbyqxmd.com/read/29076540/osteogenic-differentiation-in-dedifferentiated-liposarcoma-a-study-of-36-cases-in-comparison-to-the-cases-without-ossification
#15
Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Takeaki Ishii, Yoshihiro Nishida, Hiroshi Urakawa, Ichiro Ito, Mitsuru Takahashi, Takeshi Inoue, Masafumi Ito, Yuuki Ohara, Yoshinao Oda, Shinya Toyokuni
AIMS: Ossification is occasionally found in dedifferentiated liposarcoma (DDLPS). The aims of this study were to elucidate whether the formed bone tissue is usually produced by tumor cells or by reactive non-neoplastic cells, and to reveal the clinicopathological characteristics of DDLPS with ossification. METHODS AND RESULTS: We examined 36 cases of ossified DDLPS by comparing them to 31 cases of non-ossified DDLPS. MDM2 amplification was confirmed in osteocytes and/or osteoblastic cells in all but one ossified DDLPS cases (27/28) using fluorescence in-situ hybridization, although morphological impression of ossification was mostly metaplastic looking (27/36) or high grade osteosarcoma like (6/36)...
October 27, 2017: Histopathology
https://www.readbyqxmd.com/read/29044604/epstein-barr-virus-positive-mucocutaneous-ulcer-in-a-background-of-crohn-s-disease-and-waldenstr%C3%A3-m-macroglobulinemia-a-case-report-highlighting-diagnostic-pitfalls
#16
Larissa Sena Teixeira Mendes, James McCaul, Andrew Wotherspoon, Ayoma D Attygalle
A specialist haematopathology opinion was sought on a left palatine tonsillar excision biopsy performed for suspected carcinoma. The patient, a 72-year old male, presented with oropharyngeal dysphagia in May 2015 and was diagnosed with hypertrophic, ulcerated lichen planus on an incision biopsy of a white patch on the posterior third of the tongue. Topical steroids were commenced with clinical improvement. This article is protected by copyright. All rights reserved.
October 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29034552/cervical-carcinomas-with-a-micropapillary-component-a-clinicopathological-study-of-8-cases
#17
Colin J R Stewart, M H E Koay, Connull Leslie, Nathan Acott, Yee C Leung
AIMS: Micropapillary carcinomas, or carcinomas with a micropapillary component, are well-recognised in the breast and other anatomical sites. However, they have seldom been described in the cervix. In this report we present a clinicopathological analysis of eight cervical tumours that showed at least a focal (≥5%) component of micropapillary carcinoma. METHODS AND RESULTS: The study group comprised eight cervical carcinomas (4 adenocarcinomas and 4 adenosquamous carcinomas) with a micropapillary component...
October 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29023984/partial-to-complete-abrogation-of-the-sub-epithelial-macrophage-barrier-against-the-gut-microbiota-in-patients-with-ulcerative-colitis-and-crohn-s-colitis
#18
Carlos A Rubio, Cord Langner, Peter T Schmidt
AIMS: The integrity of the subepithelial band of indigenous macrophages in the lamina-propria (SLP-MΦ) is crucial in deterring the commensal gut-microbiota from host-assailment. The breakdown of the SLP-MΦ barrier results in microbiota inflow and improper immune responses; this might lead to IBD. During inflammation, the SLP-MΦ-barrier is reinforced by inflammation-elicited MΦ (IEMΦ, derived from blood-circulating monocytes). The aim was to explore the characteristics of the SLP-MΦ band in a cohort of biopsies without inflammation, in patients with ulcerative colitis-in remission (UCre), and in patients with right-sided Crohn's colitis (RCC)...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29023936/understanding-patterns-of-invasion-a-novel-approach-to-assessment-of-podoplanin-expression-in-prediction-of-lymph-node-metastasis-in-oscc
#19
Ankita Sharma, Karen Boaz, Srikant Natarajan
BACKGROUND: Cellular motility is considered central to the process of metastasis and podoplanin expression can be explored as a prospective link due to its ability to modulate actin cytoskeleton. We aimed to evaluate the tumoural expression of D2-40 (mono-clonal antibody to podoplanin) in pathologically neck-node negative/positive cases (pN0/N+) to characterise the pattern of invasion, potentially explaining the role of various patterns of invasion in causing tumor metastasis. METHODS: Paraffin-embedded tissue blocks of 60 cases of OSCC of known nodal status were selected for immunohistochemical staining of tumour (invasive front) by D2-40 (anti-podoplanin) along with routine staining by Haematoxylin & Eosin...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29023932/xanthogranulomatous-cholecystitis-exhibits-overlapping-histologic-features-with-igg4-related-cholecystitis
#20
Soon Auck Hong, You Na Sung, Hyoung Jung Kim, Sang Soo Lee, Jae Hoon Lee, Chul-Soo Ahn, Shin Hwang, Eunsil Yu, Yoh Zen, Myung-Hwan Kim, Seung-Mo Hong
AIMS: Xanthogranulomatous cholecystitis (XGC), an unusual histologic variant of chronic cholecystitis, is characterized by mixed foamy histiocytic and lymphoplasmocytic infiltration and fibrosis. Radiologically, the poorly defined nodular growth pattern often leads to the misinterpretation of XGC as gallbladder cancer. In this study, we aimed to identify the relationship of XGC with IgG4-related cholecystitis, METHODS AND RESULTS: We re-evaluated 57 surgically resected XGCs and 104 conventional chronic cholecystitis cases, according to the histologic features observed in IgG4-related disease, including lymphoplasmocytic infiltration, storiform fibrosis, obliterative phlebitis, and IgG4-positive plasma cells...
October 11, 2017: Histopathology
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