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Heart: Official Journal of the British Cardiac Society

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https://www.readbyqxmd.com/read/29444808/cochrane-corner-pcsk9-monoclonal-antibodies-for-the-primary-and-secondary-prevention-of-cardiovascular-disease
#1
EDITORIAL
Amand F Schmidt, Lucy S Pearce, John T Wilkins, Juan P Casas, Aroon D Hingorani
No abstract text is available yet for this article.
February 14, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29444807/hypoxic-challenge-testing-fitness-to-fly-in-children-with-complex-congenital-heart-disease
#2
Nitha N Naqvi, Victoria L Doughty, Luke Starling, Rodney C Franklin, Simon Ward, Piers E F Daubeney, Ian M Balfour-Lynn
OBJECTIVE: Commercial airplanes fly with an equivalent cabin fraction of inspired oxygen of 0.15, leading to reduced oxygen saturation (SpO 2 ) in passengers. How this affects children with complex congenital heart disease (CHD) is unknown. We conducted Hypoxic Challenge Testing (HCT) to assess need for inflight supplemental oxygen. METHODS: Children aged <16 years had a standard HCT. They were grouped as (A) normal versus abnormal baseline SpO 2 (≥95% vs <95%) and (B) absence versus presence of an actual/potential right-to-left (R-L) shunt...
February 14, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29440192/impact-of-anticoagulation-therapy-on-valve-haemodynamic-deterioration-following-transcatheter-aortic-valve-replacement
#3
María Del Trigo, Antonio J Muñoz-García, Azeem Latib, Vincent Auffret, Harindra C Wijeysundera, Luis Nombela-Franco, Enrique Gutierrez, Asim N Cheema, Vicenç Serra, Ignacio J Amat-Santos, Joelle Kefer, Luis Miguel Benitez, Florence Leclercq, Antonio Mangieri, Hervé Le Breton, Pilar Jiménez-Quevedo, Bruno Garcia Del Blanco, Antonio Dager, Omar Abdul-Jawad Altisent, Rishi Puri, Philippe Pibarot, Josep Rodés-Cabau
OBJECTIVE: To evaluate the changes in transvalvular gradients and the incidence of valve haemodynamic deterioration (VHD) following transcatheter aortic valve replacement (TAVR), according to use of anticoagulation therapy. METHODS AND RESULTS: This multicentre study included 2466 patients (46% men; mean age 81±7 years) who underwent TAVR with echocardiography performed at 12-month follow-up. Anticoagulation therapy was used in 707 patients (28.7%) following TAVR (AC group)...
February 13, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29440185/differing-associations-for-sport-versus-occupational-physical-activity-and-cardiovascular-risk
#4
Marco Mario Ferrario, Mattia Roncaioli, Giovanni Veronesi, Andreas Holtermann, Els Clays, Rossana Borchini, Marco Cavicchiolo, Guido Grassi, Giancarlo Cesana
OBJECTIVES: We investigate the independent and interacting long-term associations of occupational physical activity (OPA) and sport physical activity (SpPA) with the incidence of coronary heart disease (CHD) and cardiovascular diseases (CVD; CHD plus ischaemic stroke) in North Italian male workers. METHODS: 3574 employed men aged 25-64 years, free of CVD at baseline, recruited in three population-based and one factory-based cohorts, were included in the analysis...
February 9, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29440184/household-air-pollution-and-measures-of-blood-pressure-arterial-stiffness-and-central-haemodynamics
#5
Jill Baumgartner, Ellison Carter, James J Schauer, Majid Ezzati, Stella S Daskalopoulou, Marie-France Valois, Ming Shan, Xudong Yang
OBJECTIVE: We evaluated the exposure-response associations between personal exposure to air pollution from biomass stoves and multiple vascular and haemodynamic parameters in rural Chinese women. METHODS: We analysed the baseline information from a longitudinal study in southwestern China. Women's brachial and central blood pressure and pulse pressure, carotid-femoral pulse wave velocity and augmentation index, and their 48-hour personal exposures to fine particulate matter (PM 2...
February 9, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29440183/ambulatory-blood-pressure-and-long-term-risk-for-atrial-fibrillation
#6
Valérie Tikhonoff, Tatiana Kuznetsova, Lutgarde Thijs, Nicholas Cauwenberghs, Katarzyna Stolarz-Skrzypek, Jitka Seidlerová, Sofia Malyutina, Natasza Gilis-Malinowska, Ewa Swierblewska, Kalina Kawecka-Jaszcz, Jan Filipovský, Krzysztof Narkiewicz, Gregory Y H Lip, Edoardo Casiglia, Jan A Staessen
OBJECTIVE: Data on the contribution of ambulatory blood pressure (ABP) components to the risk of developing atrial fibrillation (AF) are limited. We prospectively tested the hypothesis that ABP may represent a potentially modifiable risk factor for the development of AF in a European population study. METHODS: We recorded daytime blood pressure (BP) in 3956 subjects randomly recruited from the general population in five European countries. Of these participants, 2776 (70...
February 9, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29439169/cochrane-corner-complete-versus-culprit-only-revascularisation-in-st-segment-elevation-myocardial-infarction-with-multivessel-disease
#7
EDITORIAL
Claudio A Bravo, Sameer A Hirji, Deepak L Bhatt, Christian Gluud, David P Faxon, E Magnus Ohman, Tsuyoshi Kaneko, Thomas Engstrøm, Dan Eik Høfsten, J Matthew Brennan
No abstract text is available yet for this article.
February 8, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29436381/subcutaneous-treprostinil-in-congenital-heart-disease-related-pulmonary-arterial-hypertension
#8
Nika Skoro-Sajer, Christian Gerges, Olga Hajnalka Balint, Dora Kohalmi, Monika Kaldararova, Iveta Simkova, Johannes Jakowitsch, Harald Gabriel, Helmut Baumgartner, Mario Gerges, Roela Sadushi-Kolici, David S Celermajer, Irene Marthe Lang
OBJECTIVE: To assess the efficacy and safety of subcutaneous treprostinil in adult patients with congenital heart disease (CHD)-associated pulmonary arterial hypertension (PAH) after 12 months of treatment. METHODS: Consecutive adult patients with CHD-PAH received subcutaneous treprostinil to maximum tolerated doses in an observational study. RESULTS: Advanced CHD-PAH patients with WHO class III or IV disease (n=32, age 40±10 years, 20 females) received treprostinil for suboptimal response to bosentan (n=12), WHO functional class IV disease (FC, n=7) or prior to bosentan approval (n=13)...
February 7, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29437704/coronary-intervention-door-to-balloon-time-and-outcomes-in-st-elevation-myocardial-infarction-a-meta-analysis
#9
Chee Yoong Foo, Kwadwo Osei Bonsu, Brahmajee K Nallamothu, Christopher M Reid, Teerapon Dhippayom, Daniel D Reidpath, Nathorn Chaiyakunapruk
OBJECTIVE: This study aims to determine the relationship between door-to-balloon delay in primary percutaneous coronary intervention and ST-elevation myocardial infarction (MI) outcomes and examine for potential effect modifiers. METHODS: We conducted a systematic review and meta-analysis of prospective observational studies that have investigated the relationship of door-to-balloon delay and clinical outcomes. The main outcomes include mortality and heart failure...
February 5, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29437887/preventing-stroke-in-patients-with-heart-failure-why-are-patients-losing-out
#10
EDITORIAL
Martin R Cowie, Rosita Zakeri
No abstract text is available yet for this article.
February 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29437886/secondary-mitral-regurgitation-part-2-deliberations-on-mitral-surgery-and-transcatheter-repair
#11
REVIEW
William H Gaasch, Theo E Meyer
Secondary mitral regurgitation (MR) develops as a consequence of postinfarction remodelling of the ventricle or other causes of left ventricular (LV) dilatation and dysfunction. The presence of MR amplifies the poor prognosis of the failing ventricle, but it has not been established whether the adverse outcomes stem from the MR or whether the MR is simply a marker of progressive LV dysfunction. In this article, an attempt will be made to clarify the clinical impact of mitral surgery and transcatheter repair in patients with secondary MR...
February 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29437885/association-of-different-antiplatelet-therapies-with-mortality-after-primary-percutaneous-coronary-intervention
#12
Ivan Olier, Alex Sirker, David J R Hildick-Smith, Tim Kinnaird, Peter Ludman, Mark A de Belder, Andreas Baumbach, Jonathan Byrne, Muhammad Rashid, Nick Curzen, Mamas A Mamas
OBJECTIVES: Prasugrel and ticagrelor both reduce ischaemic endpoints in high-risk acute coronary syndromes, compared with clopidogrel. However, comparative outcomes of these two newer drugs in the context of primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) remains unclear. We sought to examine this question using the British Cardiovascular Interventional Society national database in patients undergoing primary PCI for STEMI. METHODS: Data from January 2007 to December 2014 were used to compare use of P2Y12 antiplatelet drugs in primary PCI in >89 000 patients...
February 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29386325/socioeconomic-deprivation-and-mode-specific-outcomes-in-patients-with-chronic-heart-failure
#13
Klaus K Witte, Peysh A Patel, Andrew M N Walker, Clyde B Schechter, Michael Drozd, Anshuman Sengupta, Rowenna Byrom, Lorraine C Kearney, Robert J Sapsford, Mark T Kearney, Richard M Cubbon
OBJECTIVE: To characterise the association between socioeconomic deprivation and adverse outcomes in patients with chronic heart failure (CHF). METHODS: We prospectively observed 1802 patients with CHF and left ventricular ejection fraction (LVEF) ≤45%, recruited in four UK hospitals between 2006 and 2014. We assessed the association between deprivation defined by the UK Index of Multiple Deprivation (IMD) and: mode-specific mortality (mean follow-up 4 years); mode-specific hospitalisation; and the cumulative duration of hospitalisation (after 1 year)...
January 31, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29382691/resting-heart-rate-what-is-normal
#14
EDITORIAL
David Nanchen
No abstract text is available yet for this article.
January 30, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29382690/man-in-his-50s-with-chest-pain-and-dyspnoea
#15
Yuki Obayashi, Chisato Izumi, Yoshihisa Nakagawa
CLINICAL INTRODUCTION: A man in his 50s with sudden-onset chest pain and dyspnoea was transferred to the emergency room. He had a history of aortic valve replacement due to aortic regurgitation with a mechanical valve 6 years previously. Heart rate was 90 bpm, and blood pressure was too low to measure. In the emergency room, he presented with severe dyspnoea and a chest X-ray showed severe lung congestion (figure 1A). ECG showed complete left bundle branch block. His respiratory status rapidly worsened, and he went into cardiopulmonary arrest...
January 30, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29371376/renin-angiotensin-aldosterone-blockade-reduces-atrial-fibrillation-in-hypertrophic-cardiomyopathy
#16
Chen-Yu Huang, Yao-Hsu Yang, Lian-Yu Lin, Chia-Ti Tsai, Juey-Jen Hwang, Pau-Chung Chen, Jiunn-Lee Lin
OBJECTIVES: Atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) is associated with increased mortality, mainly mediated by increased thromboembolic events and progressive heart failure. Many studies suggested inhibition of renin-angiotensin-aldosterone system (RAAS) could reduce new AF in various clinical conditions. However, evidence concerning the effects of RAAS inhibitors on AF prevention remains unclear in HCM. Our study is to investigate whether treatment with ACE inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) could lower the risk of new AF in HCM...
January 25, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29371375/socioeconomic-status-and-outcomes-in-heart-failure-with-reduced-ejection-fraction
#17
EDITORIAL
Iain Squire
No abstract text is available yet for this article.
January 25, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29371374/reasons-for-and-consequences-of-oral-anticoagulant-underuse-in-atrial-fibrillation-with-heart-failure
#18
Gianluigi Savarese, Ulrik Sartipy, Leif Friberg, Ulf Dahlström, Lars H Lund
OBJECTIVE: Atrial fibrillation (AF) is common in patients with heart failure (HF), and oral anticoagulants (OAC) are indicated. The aim was to assess prevalence of, predictors of and consequences of OAC non-use. METHODS: We included patients with AF, HF and no previous valve replacement from the Swedish Heart Failure Registry. High and low CHA2DS2-VASc and HAS-BLED scores were defined as above/below median. Multivariable logistic regressions were used to assess the associations between baseline characteristics and OAC use and between CHA2DS2-VASc and HAS-BLED scores and OAC use...
January 25, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29371373/interventional-treatments-and-risk-factors-in-patients-born-with-hypoplastic-left-heart-syndrome-in-england-and-wales-from-2000-to-2015
#19
Libby Rogers, Christina Pagel, Ian D Sullivan, Muhammed Mustafa, Victor Tsang, Martin Utley, Catherine Bull, Rodney C Franklin, Kate L Brown
OBJECTIVE: To describe the long-term outcomes, treatment pathways and risk factors for patients diagnosed with hypoplastic left heart syndrome (HLHS) in England and Wales. METHODS: The UK's national audit database captures every procedure undertaken for congenital heart disease and updated life status for resident patients in England and Wales. Patients with HLHS born between 2000 and 2015 were identified using codes from the International Paediatric and Congenital Cardiac Code...
January 25, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29353251/cardiopulmonary-resuscitation-the-science-behind-the-hands
#20
REVIEW
Andrew W Harris, Peter J Kudenchuk
Sudden cardiac arrest is a leading cause of death worldwide. Despite significant advances in resuscitation science since the initial use of external chest compressions in humans nearly 60 years ago, there continues to be wide variability in rates of successful resuscitation across communities. The American Heart Association (AHA) and European Resuscitation Council emphasise the importance of high-quality chest compressions as the foundation of resuscitation care. We review the physiological basis for the association between chest compression quality and clinical outcomes and the scientific basis for the AHA's key metrics for high-quality cardiopulmonary resuscitation...
January 20, 2018: Heart: Official Journal of the British Cardiac Society
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