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Heart: Official Journal of the British Cardiac Society

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https://www.readbyqxmd.com/read/29217636/novel-united-kingdom-prognostic-model-for-30-day-mortality-following-transcatheter-aortic-valve-implantation
#1
Glen P Martin, Matthew Sperrin, Peter F Ludman, Mark A de Belder, Simon R Redwood, Jonathan N Townend, Mark Gunning, Neil E Moat, Adrian P Banning, Iain Buchan, Mamas A Mamas
OBJECTIVE: Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across registries. The aim of this study was to derive a UK-TAVI CPM to predict 30-day mortality risk for benchmarking purposes. METHODS: A two-step modelling strategy was undertaken: first, data from the UK-TAVI Registry between 2009 and 2014 were used to develop a multivariable logistic regression CPM using backwards stepwise regression...
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217635/early-days-in-congenital-heart-surgery-in-the-uk-the-peacock-club
#2
Tom Treasure
No abstract text is available yet for this article.
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217634/anthracycline-cardiotoxicity-an-update-on-mechanisms-monitoring-and-prevention
#3
REVIEW
Peter A Henriksen
Anthracycline chemotherapy causes dose-related cardiomyocyte injury and death leading to left ventricular dysfunction. Clinical heart failure may ensue in up to 5% of high-risk patients. Improved cancer survival together with better awareness of the late effects of cardiotoxicity has led to growing recognition of the need for surveillance of anthracycline-treated cancer survivors with early intervention to treat or prevent heart failure. The main mechanism of anthracycline cardiotoxicity is now thought to be through inhibition of topoisomerase 2β resulting in activation of cell death pathways and inhibition of mitochondrial biogenesis...
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217633/stress-echocardiography-in-patients-with-native-valvular-heart-disease
#4
REVIEW
Patrizio Lancellotti, Raluca Dulgheru, Yun Yun Go, Tadafumi Sugimoto, Stella Marchetta, Cécile Oury, Madalina Garbi
Valve stress echocardiography (VSE) can be performed as exercise stress echocardiography (ESE) or dobutamine stress echocardiography (DSE) depending on the patient's clinical status, severity and type of valve disease. ESE combines exercise testing with two-dimensional grey scale and Doppler echocardiography during exercise. Thus, it provides objective assessment of symptomatic status (exercise test), as well as exercise-induced changes of a series of echocardiographic parameters (different depending on the valve disease type), which yield prognostic information in individual patients and help in a better treatment planning...
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217632/perioperative-management-of-anticoagulant-and-antiplatelet-therapy
#5
Alfonso Tafur, James Douketis
No abstract text is available yet for this article.
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217631/how-to-deliver-optimal-cardiac-resynchronisation-therapy
#6
Panagiota Anna Chousou, Peter J Pugh
No abstract text is available yet for this article.
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29208632/right-ventricular-exercise-contractile-reserve-and-outcomes-after-early-surgery-for-primary-mitral-regurgitation
#7
Emilie Vitel, Elena Galli, Christophe Leclercq, Maxime Fournet, Christian Bosseau, Hervé Corbineau, Guillame Bouzille, Erwan Donal
OBJECTIVE: To assess if the lack of development of right ventricular (RV) contractile reserve during exercise echocardiography (ex-echo) might be a predictor of postoperative major adverse cardiovascular events (MACEs) in patients with primary mitral regurgitation (pMR) undergoing early surgery. METHODS: Comprehensive resting and ex-echo were performed in 142 asymptomatic patients (58±21 years, 68% men, New York Heart Association functional class ≤2) with isolated severe pMR and preserved left ventricular (LV) function (LV ejection >60%, LV end-systolic diameter <45 mm) undergoing mitral valve replacement (n=20) or repair...
December 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29203574/blunt-chest-trauma-a-clinical-chameleon
#8
REVIEW
Kaveh Eghbalzadeh, Anton Sabashnikov, Mohamed Zeriouh, Yeong-Hoon Choi, Alexander C Bunck, Navid Mader, Thorsten Wahlers
The incidence of blunt chest trauma (BCT) is greater than 15% of all trauma admissions to the emergency departments worldwide and is the second leading cause of death after head injury in motor vehicle accidents. The mortality due to BCT is inhomogeneously described ranging from 9% to 60%. BCT is commonly caused by a sudden high-speed deceleration trauma to the anterior chest, leading to a compression of the thorax. All thoracic structures might be injured as a result of the trauma. Complex cardiac arrhythmia, heart murmurs, hypotension, angina-like chest pain, respiratory insufficiency or distention of the jugular veins may indicate potential cardiac injury...
December 4, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29196542/cardiac-myosin-binding-protein-c-is-a-novel-marker-of-myocardial-injury-and-fibrosis-in-aortic-stenosis
#9
Atul Anand, Calvin Chin, Anoop S V Shah, Jacek Kwieciński, Alex Vesey, Joanna Cowell, Ekkehard Weber, Thomas Kaier, David E Newby, Marc Dweck, Michael S Marber, Nicholas L Mills
OBJECTIVE: Cardiac myosin-binding protein C (cMyC) is an abundant sarcomeric protein and novel highly specific marker of myocardial injury. Myocyte death characterises the transition from hypertrophy to replacement myocardial fibrosis in advanced aortic stenosis. We hypothesised that serum cMyC concentrations would be associated with cardiac structure and outcomes in patients with aortic stenosis. METHODS: cMyC was measured in two cohorts in which serum had previously been prospectively collected: a mechanism cohort of patients with aortic stenosis (n=161) and healthy controls (n=46) who underwent cardiac MRI, and an outcome cohort with aortic stenosis (n=104) followed for a median of 11...
December 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29196541/validation-of-the-grown-ups-with-congenital-heart-disease-score
#10
Jürgen Hörer, Régine Roussin, Emanuel LeBret, Mohamed Ly, Jarrah Abdullah, Rafaella Marzullo, Jelena Pabst von Ohain, Emre Belli
OBJECTIVES: Adults with congenital heart disease in need of heart surgery frequently present with significant comorbidity. Furthermore, additional technical difficulties often related to redo operations increase the risk for postoperative mortality and morbidity. Hence, next to the type of the procedure, additional procedure-dependent and procedure-independent factors have to be considered for risk evaluation. The recently proposed grown-ups with congenital heart disease (GUCH) mortality and morbidity scores account for these additional risk factors...
December 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29196540/propensity-score-matched-analysis-of-partial-atrioventricular-septal-defect-repair-in-infancy
#11
Edward Buratto, Michael Daley, Xin Tao Ye, Dorothy J Radford, Nelson Alphonso, Christian P Brizard, Yves d'Udekem, Igor E Konstantinov
OBJECTIVE: Partial atrioventricular septal defect (pAVSD) is usually repaired between 2 and 4 years of age with excellent results. Repair during infancy has been associated with poorer outcomes. However, most infants in reported series had heart failure or significant left atrioventricular valve (LAVV) regurgitation. The impact of surgery during infancy on outcomes remains unclear. METHODS: All children at three institutions who underwent repair of pAVSD from 1975 to 2015 were included...
December 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29191806/atrial-fibrillation-prevention-an-appraisal-of-current-evidence
#12
REVIEW
Giuseppe Boriani, Marco Proietti
Atrial fibrillation (AF), which is the most diagnosed arrhythmia, is becoming a significant issue for health policy-makers. In particular, more and more attention is being devoted to AF prevention. Indeed, several studies recently published point out how targeted interventions could be useful in reducing the risk of AF occurrence (or recurrence). In this review, we briefly summarised the role of the major risk factors associated with the incidence of AF, as well as the effectiveness of interventions aimed at controlling these risk factors...
November 30, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29180542/myocardial-revascularisation-in-high-risk-subjects
#13
Satpal S Arri, Tiffany Patterson, Rupert P Williams, Konstantinos Moschonas, Christopher P Young, Simon R Redwood
No abstract text is available yet for this article.
November 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29175979/takayasu-arteritis-challenges-in-diagnosis-and-management
#14
REVIEW
Esther S H Kim, Joshua Beckman
Takayasu arteritis (TA) is a rare disease affecting chiefly young women, although it can affect both men and women and persons of many different ethnicities. TA carries a high morbidity rate, but importantly, overall mortality has declined over time such that the 15-year survival rate has increased from 82.9% for patients diagnosed between 1957 and 1975 to 96.5% for those diagnosed from 1976 to 1990. Severity of presenting arterial complications and delay to diagnosis have also decreased over the past decade owing to advances in non-invasive diagnostic imaging and the development of medical therapies...
November 25, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29175978/constrictive-pericarditis-diagnosis-management-and-clinical-outcomes
#15
REVIEW
Terrence D Welch
Constrictive pericarditis (CP) is a form of diastolic heart failure that arises because an inelastic pericardium inhibits cardiac filling. This disorder must be considered in the differential diagnosis for unexplained heart failure, particularly when the left ventricular ejection fraction is preserved. Risk factors for the development of CP include prior cardiac surgery and radiation therapy, but most cases are still deemed to be idiopathic. Making the diagnosis may be challenging and requires meticulous echocardiographic assessment, often supplemented by cross-sectional cardiac imaging and haemodynamic catheterisation...
November 25, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29175977/patients-with-atrial-fibrillation-and-coronary-events-are-we-any-closer-to-coming-out-from-the-labyrinth-of-the-various-antithrombotic-strategies
#16
EDITORIAL
Giuseppe Patti
No abstract text is available yet for this article.
November 25, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29175976/heart-rate-at-first-postdischarge-visit-and-outcomes-in-patients-with-heart-failure
#17
Tae-Hun Kim, Hyungseop Kim, In-Cheol Kim, Hyuck-Jun Yoon, Hyoung-Seob Park, Yun-Kyeong Cho, Chang-Wook Nam, Seongwook Han, Seung-Ho Hur, Yoon-Nyun Kim
OBJECTIVE: Heart rate control is important to prevent adverse outcomes in patients with heart failure (HF). However, postdischarge activity may worsen heart rate control, resulting in readmission. This study aimed to explore the implications of the heart rate differences between discharge and the first outpatient visit (D-O diff). METHODS: We retrospectively identified 458 patients (male: 46%; mean age: 72 years) discharged after HF. The heart rates at admission, discharge and first outpatient visit were analysed...
November 25, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29175975/lamin-and-the-heart
#18
REVIEW
Gabriella Captur, Eloisa Arbustini, Gisèle Bonne, Petros Syrris, Kevin Mills, Karim Wahbi, Saidi A Mohiddin, William J McKenna, Stephen Pettit, Carolyn Y Ho, Antoine Muchir, Paul Gissen, Perry M Elliott, James C Moon
Lamins A and C are intermediate filament nuclear envelope proteins encoded by the LMNA gene. Mutations in LMNA cause autosomal dominant severe heart disease, accounting for 10% of dilated cardiomyopathy (DCM). Characterised by progressive conduction system disease, arrhythmia and systolic impairment, lamin A/C heart disease is more malignant than other common DCMs due to high event rates even when the left ventricular impairment is mild. It has several phenotypic mimics, but overall it is likely to be an under-recognised cause of DCM...
November 25, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29170358/cardiopulmonary-fitness-in-children-with-congenital-heart-diseases-versus-healthy-children
#19
Pascal Amedro, Arthur Gavotto, Sophie Guillaumont, Helena Bertet, Marie Vincenti, Gregoire De La Villeon, Charlène Bredy, Philippe Acar, Caroline Ovaert, Marie-Christine Picot, Stefan Matecki
OBJECTIVE: We aimed to compare the cardiopulmonary fitness of children with congenital heart diseases (CHD) with that of age-adjusted and gender-adjusted controls. We also intended to identify clinical characteristics associated with maximum oxygen uptake (VO2max) in this population. METHODS AND RESULTS: We included in a cross-sectional multicentre study a total of 798 children (496 CHD and 302 controls) who underwent a complete cardiopulmonary exercise test (CPET)...
November 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29170357/role-of-cardiovascular-magnetic-resonance-in-the-management-of-patients-with-stable-coronary-artery-disease
#20
REVIEW
Manish Motwani, Peter P Swoboda, Sven Plein, John P Greenwood
Cardiovascular magnetic resonance (CMR) assesses cardiac function, ischaemia, viability and tissue characterisation, all within a single scan. Many studies regarding the role of CMR in stable coronary artery disease (CAD) have been published over the last decade providing important technical advances, large-scale clinical validation and prognostic data. As a result, CMR has emerged as a highly accurate technique for diagnosis and risk stratification in stable CAD and has been incorporated into national and international guidelines...
November 23, 2017: Heart: Official Journal of the British Cardiac Society
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