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Heart: Official Journal of the British Cardiac Society

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https://www.readbyqxmd.com/read/30232090/how-to-succeed-as-an-academic-cardiologist-a-conversation-for-the-aspiring-cardiology-trainee
#1
Catherine M Otto
No abstract text is available yet for this article.
September 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228252/cochrane-corner-inotropic-agents-and-vasodilator-strategies-for-cardiogenic-shock-or-low-cardiac-output-syndrome
#2
EDITORIAL
Julia Schumann
No abstract text is available yet for this article.
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228251/accuracy-of-24-hour-ambulatory-blood-pressure-monitoring-by-a-novel-cuffless-device-in-clinical-practice
#3
Philipp Krisai, Annina Salome Vischer, Leo Kilian, Andrea Meienberg, Michael Mayr, Thilo Burkard
OBJECTIVE: Recently, a cuffless blood pressure (BP) measurement device using pulse transit time (PTT) for beat-to-beat calculation of BP values has been validated over a short time period. However, it remains unknown how values obtained with this device compare with standard ambulatory measurements over a 24-hour period. We hypothesised that BP values measured by a cuffless PTT device (TestBP) are comparable with measurements by a standard upper arm cuff-based BP device (RefBP) in clinical practice over 24 hours...
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228250/resistant-hypertension-in-times-of-changing-definitions-and-treatment-recommendations
#4
EDITORIAL
Milad Nazarzadeh, Ana-Catarina Pinho-Gomes, Kazem Rahimi
No abstract text is available yet for this article.
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228249/cardiovascular-imaging-in-turner-syndrome-state-of-the-art-practice-across-the-lifespan
#5
REVIEW
Kristian H Mortensen, Luciana Young, Julie De Backer, Michael Silberbach, Ronnie Thomas Collins, Anthonie L Duijnhouwer, Bejal Pandya, Claus H Gravholt, Leo Lopez, Jolien W Roos-Hesselink
Cardiovascular imaging is essential to providing excellent clinical care for girls and women with Turner syndrome (TS). Congenital and acquired cardiovascular diseases are leading causes of the lifelong increased risk of premature death in TS. Non-invasive cardiovascular imaging is crucial for timely diagnosis and treatment planning, and a systematic and targeted imaging approach should combine echocardiography, cardiovascular magnetic resonance and, in select cases, cardiac CT. In recent decades, evidence has mounted for the need to perform cardiovascular imaging in all females with TS irrespective of karyotype and phenotype...
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228248/b-type-natriuretic-peptide-disease-progression-and-clinical-outcomes-in-atrial-fibrillation
#6
Taku Inohara, Sunghee Kim, Karen Pieper, Rosalia G Blanco, Larry A Allen, Gregg C Fonarow, Bernard J Gersh, Michael D Ezekowitz, Peter R Kowey, James A Reiffel, Gerald V Naccarelli, Paul S Chan, Kenneth W Mahaffey, Daniel E Singer, James V Freeman, Benjamin A Steinberg, Eric D Peterson, Jonathan P Piccini
OBJECTIVE: The association with B-type natriuretic peptide (BNP), disease progression and outcomes in patients with atrial fibrillation (AF) has not been thoroughly investigated. METHODS: We evaluated the association between BNP levels and outcomes, including AF progression, composite outcome of major adverse cardiovascular or neurological events (MACNE) and major bleeding, via pooled logistic regression and Cox frailty models in Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II registry...
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228247/diagnostic-accuracy-and-bayesian-analysis-of-new-international-ecg-recommendations-in-paediatric-athletes
#7
Gavin McClean, Nathan R Riding, Guido Pieles, Victoria Watt, Carmen Adamuz, Sanjay Sharma, Keith P George, David Oxborough, Mathew G Wilson
OBJECTIVE: Historically, electrocardiographic (ECG) interpretation criteria for athletes were only applicable to adults. New international recommendations now account for athletes ≤16 years, but their clinical appropriateness is unknown. We sought to establish the diagnostic accuracy of new international ECG recommendations against the Seattle criteria and 2010 European Society of Cardiology (ESC) recommendations in paediatric athletes using receiver operator curve analysis. Clinical context was calculated using Bayesian analysis...
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30228246/toxicity-of-cancer-therapy-what-the-cardiologist-needs-to-know-about-angiogenesis-inhibitors
#8
REVIEW
Stephen J H Dobbin, Alan C Cameron, Mark C Petrie, Robert J Jones, Rhian M Touyz, Ninian N Lang
Clinical outcomes for patients with a wide range of malignancies have improved substantially over the last two decades. Tyrosine kinase inhibitors (TKIs) are potent signalling cascade inhibitors and have been responsible for significant advances in cancer therapy. By inhibiting vascular endothelial growth factor receptor (VEGFR)-mediated tumour blood vessel growth, VEGFR-TKIs have become a mainstay of treatment for a number of solid malignancies. However, the incidence of VEGFR-TKI-associated cardiovascular toxicity is substantial and previously under-recognised...
September 18, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30209127/cardiac-transplantation-indications-eligibility-and-current-outcomes
#9
Sai Kiran Bhagra, Stephen Pettit, Jayan Parameshwar
No abstract text is available yet for this article.
September 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30209126/effect-of-apixaban-compared-with-warfarin-on-coagulation-markers-in-atrial-fibrillation
#10
Christina Christersson, Lars Wallentin, Ulrika Andersson, John H Alexander, Marco Alings, Raffaele De Caterina, Bernard J Gersh, Christopher B Granger, Sigrun Halvorsen, Michael Hanna, Kurt Huber, Elaine M Hylek, Renato D Lopes, Byung-Hee Oh, Agneta Siegbahn
OBJECTIVES: Compare the effect of apixaban and warfarin on coagulation and primary haemostasis biomarkers in atrial fibrillation (AF). METHODS: The biomarker substudy from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial included 4850 patients with AF randomised to treatment with apixaban or warfarin. Sixty per cent of patients used vitamin K antagonist (VKA) within 7 days before randomisation. Prothrombin fragment 1+2 (F1+2), D-dimer, soluble CD40 ligand (sCD40L) and von Willebrand factor (vWF) antigen were analysed at randomisation and after 2 months of study treatment...
September 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30209125/discharge-against-medical-advice-after-hospitalisation-for-acute-myocardial-infarction
#11
Chun Shing Kwok, Mary Norine Walsh, Annabelle Volgman, Mirvat Alasnag, Glen Philip Martin, Diane Barker, Ashish Patwala, Rodrigo Bagur, David L Fischman, Mamas A Mamas
BACKGROUND: Discharge against medical advice (AMA) occurs infrequently but is associated with poor outcomes. There are limited descriptions of discharges AMA in national cohorts of patients with acute myocardial infarction (AMI). This study aims to evaluate discharge AMA in AMI and how it affects readmissions. METHODS: We conducted a cohort study of patients with AMI in USA in the Nationwide Readmission Database who were admitted between the years 2010 and 2014...
September 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30209124/coronary-artery-bypass-graft-versus-percutaneous-coronary-intervention-in-acute-heart-failure
#12
Sang Eun Lee, Hae-Young Lee, Hyun-Jai Cho, Won-Seok Choe, Hokon Kim, Jin Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Jae-Joong Kim, Byung-Hee Oh
OBJECTIVE: Myocardial ischaemia is a leading cause of acute heart failure (AHF). However, optimal revascularisation strategies in AHF are unclear. We aimed to compare two revascularisation strategies, coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI), in patients with AHF. METHODS: Among 5625 consecutive patients enrolled prospectively in the Korean Acute Heart Failure registry from March 2011 to February 2014, 717 patients who received CABG or PCI during the index hospitalisation for AHF were included in this analysis...
September 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30209123/digoxin-and-clinical-outcomes-in-the-global-rheumatic-heart-disease-registry
#13
Ganesan Karthikeyan, Niveditha Devasenapathy, Liesl Zühlke, Mark Emmanuel Engel, Sumathy Rangarajan, Koon K Teo, Bongani M Mayosi, Salim Yusuf
OBJECTIVE: Digoxin is widely used in patients with rheumatic heart disease (RHD) despite a lack of data on its impact on clinical outcomes. We aimed to determine the association of digoxin use on clinical outcomes in patients with RHD. METHODS: We performed a retrospective analysis of the association of digoxin use with mortality at 2 years in a large RHD registry. Secondary outcomes were recurrent heart failure (HF) and hospitalisation for any cause. We assessed associations using multivariable logistic regression in the entire cohort and in subgroups of patients with atrial fibrillation (AF) and HF...
September 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30209122/cardiovascular-risk-model-performance-in-women-with-and-without-hypertensive-disorders-of-pregnancy
#14
Veerle Dam, N Charlotte Onland-Moret, W M Monique Verschuren, Jolanda M A Boer, Laura Benschop, Arie Franx, Karel G M Moons, Eric Boersma, Yvonne T van der Schouw
OBJECTIVES: Compare the predictive performance of Framingham Risk Score (FRS), Pooled Cohort Equations (PCEs) and Systematic COronary Risk Evaluation (SCORE) model between women with and without a history of hypertensive disorders of pregnancy (hHDP) and determine the effects of recalibration and refitting on predictive performance. METHODS: We included 29 751 women, 6302 with hHDP and 17 369 without. We assessed whether models accurately predicted observed 10-year cardiovascular disease (CVD) risk (calibration) and whether they accurately distinguished between women developing CVD during follow-up and not (discrimination), separately for women with and without hHDP...
September 12, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30185458/sexual-function-and-cardiovascular-disease-what-the-general-cardiologist-needs-to-know
#15
Stella Roushias, Nicholas Ossei-Gerning
No abstract text is available yet for this article.
September 5, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30181202/integration-of-echocardiographic-screening-by-non-physicians-with-remote-reading-in-primary-care
#16
Bruno R Nascimento, Andrea Z Beaton, Maria Carmo Pereira Nunes, Allison R Tompsett, Kaciane K B Oliveira, Adriana C Diamantino, Márcia M Barbosa, Tainá V Lourenço, Isabella M Teixeira, Gabriela Z L Ruiz, João Pedro P Rios, Antonio Luiz P Ribeiro, Craig Sable
INTRODUCTION: Heart disease (HD) accounts for high morbidity and mortality in Brazil. Underserved populations often suffer long delays in diagnosis. We aimed to evaluate the feasibility of integrating screening echocardiography (echo) with remote interpretation in the established primary care system (PC) in Brazil and to assess HD prevalence. METHODS: Over 11 months, 20 healthcare workers (four physicians, four nurses, and 12 technicians) at 16 PC centres were trained on simplified handheld echo protocols...
September 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30181201/demonstration-of-living-anatomy-clarifies-the-morphology-of-interatrial-communications
#17
REVIEW
Shumpei Mori, Tatsuya Nishii, Justin T Tretter, Diane E Spicer, Ken-Ich Hirata, Robert H Anderson
Inferences made regarding the postnatal anatomy of the atrial septum still tend to be based on developmental evidence. Although atrial septation is a well-defined process, it is remarkably complex and remains poorly understood. It is now established, however, that the process involves the conjugation of several myocardial structures and mesenchymal tissues of both intracardiac and extracardiac origin. The resultant postnatal morphology is equally complex, evidenced by the fact that, in the normal heart, only the floor of the oval fossa, along with its anteroinferior muscular buttress, are true anatomical septums...
September 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30181200/twenty-three-year-old-with-pleuritic-chest-pain
#18
Karina P Gopaul, Helen M Parry, Damien Cullington
CLINICAL INTRODUCTION: A 23-year-old woman followed at another medical centre for congenital heart disease (CHD) presented to our emergency clinic with 3 weeks of bilateral pleuritic chest pain. She returned from holiday in Greece 6 weeks earlier where a tattoo and nasal piercing had been performed. There was no history of night sweats or fever.Her temperature was 37.5°C, heart rate 120 beats/min, oxygen saturations 94% on room air and blood pressure 110/74. Her chest was clear and there was systolic murmur on auscultation...
September 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30181199/a-52-year-old-woman-with-ventricular-tachycardia
#19
Ana Fidalgo, Leticia Fernandez-Friera, Jorge Solis
CLINICAL INTRODUCTION: A 52-year-old woman with shortness of breath and palpitations was referred to a cardiologist. A 24-hour Holter demonstrated high density (37%) of ventricular premature beats (VPBs) and long runs of non-sustained (eventually sustained) monomorphic ventricular tachycardia (VT) with the same morphology as several VPBs detected in a 12-lead ECG (figure 1A). A transthoracic echocardiogram was performed, and the patient's evaluation was completed with a functional and gadolinium-enhanced cardiovascular MR (CMR) study (figure 1B,C) to assess structural heart disease...
September 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30181198/acute-onset-abdominal-pain-in-a-woman-in-her-30s
#20
Rory O'Donohoe, Samantha Fitzsimmons, Timothy J C Bryant
CLINICAL INTRODUCTION: A woman in her 30s presented to the emergency department with sudden-onset abdominal pain with hypotension and tachycardia. She gave a history of congenital heart disease for which she had previously undergone multiple operations. On examination she demonstrated right upper quadrant tenderness. She underwent an urgent multiphase CT (figure 1A-C).heartjnl;heartjnl-2018-313691v1/F1F1F1Figure 1(A) Arterial phase coronal CT. (B) Arterial phase axial CT. (C) Portal venous phase axial CT...
September 4, 2018: Heart: Official Journal of the British Cardiac Society
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