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Gastroenterology

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https://www.readbyqxmd.com/read/27932312/targeted-apoptosis-of-parietal-cells-is-insufficient-to-induce-metaplasia-in-stomach
#1
Joseph Burclaff, Luciana H Osaki, Dengqun Liu, James R Goldenring, Jason C Mills
Parietal cell atrophy is considered to cause metaplasia in the stomach. We developed mice that express the diphtheria toxin receptor specifically in parietal cells to induce their death, and found this to increase proliferation in the normal stem cell zone and neck but not to cause metaplastic reprogramming of chief cells. Furthermore, the metaplasia-inducing agents tamoxifen or DMP-777 still induced metaplasia even following previous destruction of parietal cells by diphtheria toxin. Atrophy of parietal cells alone is therefore not sufficient to induce metaplasia-completion of metaplastic reprogramming of chief cells requires mechanisms beyond parietal cell injury or death...
December 5, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27932311/daclatasvir-prevents-hepatitis-c-virus-by-blocking-transfer-of-viral-genome-to-assembly-sites
#2
Bertrand Boson, Solène Denolly, Fanny Turlure, Christophe Chamot, Marlène Dreux, François-Loïc Cosset
BACKGROUND & AIMS: Daclatasvir is a direct-acting antiviral agent and potent inhibitor of NS5A, which is involved in replication of the hepatitis C virus (HCV) genome, presumably via membranous web shaping, and assembly of new virions, likely via transfer of the HCV RNA genome to viral particle assembly sites. Daclatasvir inhibits the formation of new membranous web structures and, ultimately, of replication complex vesicles, but also inhibits an early assembly step. We investigated the relationship between daclatasvir-induced clustering of HCV proteins, intracellular localization of viral RNAs and inhibition of viral particle assembly...
December 5, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27923728/a-clinical-prediction-model-to-assess-risk-for-pancreatic-cancer-among-patients-with-new-onset-diabetes
#3
Ben Boursi, Brian Finkelman, Bruce J Giantonio, Kevin Haynes, Anil K Rustgi, Andrew D Rhim, Ronac Mamtani, Yu-Xiao Yang
BACKGROUND AND AIMS: Approximately 50% of all patients with pancreatic ductal adenocarcinoma (PDA) develop diabetes mellitus before their cancer diagnosis. Screening individuals with new-onset diabetes might therefore allow earlier diagnosis of PDA. We sought to develop and validate a PDA risk prediction model to identify high-risk individuals among those with new-onset diabetes. METHODS: We conducted a retrospective cohort study in a population representative database from the UK...
December 3, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27923727/novel-technique-of-submucosal-tunneling-endoscopic-resection-ster-for-en-bloc-removal-of-large-esophageal-gastrointestinal-stromal-tumor-gist
#4
Nikhil A Kumta, Monica Saumoy, Amy Tyberg, Michel Kahaleh
No abstract text is available yet for this article.
December 3, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27916669/prevalence-and-morbidity-of-undiagnosed-celiac-disease-from-a-community-based-study
#5
Rok Seon Choung, Scott A Larson, Shahryar Khaleghi, Alberto Rubio-Tapia, Inna G Ovsyannikova, Katherine S King, Joseph J Larson, Brian D Lahr, Gregory A Poland, Michael J Camilleri, Joseph A Murray
BACKGROUND & AIMS: Little is known about the prevalence and burden of undiagnosed celiac disease in individuals younger than 50 years old. We determined the prevalence and morbidity of undiagnosed celiac disease in individuals younger than 50 years in a community. METHODS: We tested sera from 31,255 residents of Olmsted County, Minnesota (younger than 50 years old) without a prior diagnosis of celiac disease assay using an assay for immunoglobulin A (IgA) against tissue transglutaminase (tTG); in subjects with positive test results, celiac disease was confirmed using an assay for endomysial IgA...
December 1, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27899016/bismuth-and-non-bismuth-quadruple-therapy-for-helicobacter-pylori-eradication-time-to-make%C3%A2-the%C3%A2-switch-in-clinical%C3%A2-practice
#6
LETTER
Jyh-Ming Liou, Jaw-Town Lin, Ming-Shiang Wu
No abstract text is available yet for this article.
November 26, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27899015/the-toronto-helicobacter-pylori-consensus-in-context
#7
LETTER
Yaron Niv
No abstract text is available yet for this article.
November 26, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893985/unusual-colonic-obstruction
#8
Yang-Yuan Chen, Cheng-Che Chen, Chia-Yu Chen
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893984/indomethacin-to-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-when-and-how
#9
LETTER
John George, Ashok K Saluja, Jamie S Barkin
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893983/a-rare-submucosal-tumor-of-the-esophagus
#10
Masayuki Shibata, Kimihide Kusafuka, Hiroyuki Ono
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893982/reply
#11
LETTER
Nikhil R Thiruvengadam, Kimberly A Forde, Vinay Chandrasekhara, Michael L Kochman
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893981/an-unusual-rash-during-evaluation-for-chronic-pancreatitis
#12
Feng Li, Benjamin Kaffenberger, Phil A Hart
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893980/managing-crohn-s-disease-after-surgery-a-patient-guide
#13
(no author information available yet)
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893979/no-excess-cancers-after-immunosuppressive-drugs-in-a-meta-analysis-of-cohorts-%C3%A2-a-mirage-related-to%C3%A2-propensity%C3%A2-bias
#14
LETTER
Laurent Beaugerie, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893978/unusual-thickened-gastric-folds-in-a-patient-with-breast-cancer
#15
Tsutomu Namikawa, Michiya Kobayashi, Kazuhiro Hanazaki
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893977/reply
#16
LETTER
Carlo A Fallone, Javier P Gisbert, Naoki Chiba, Sander Veldhuyzen van Zanten, Lori Fischbach, Richard H Hunt, Nicola L Jones, Craig Render, Grigorios I Leontiadis, Paul Moayyedi, John K Marshall
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893976/reply
#17
LETTER
Edward Shelton, Ashwin N Ananthakrishnan
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893975/gingival-carcinoma-in-a-patient-with-ulcerative-colitis
#18
Takeshi Shiraishi, Hiroyuki Shoji, Yuko Akazawa
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893974/a-surprising-case-of-acute-diarrhea-in-south-of-france
#19
Antoine Debourdeau, Magdalena Meszaros, Romain Altwegg
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893973/progressive-dysphagia-in-a-pregnant-woman
#20
Menachem Schechter, Jenny J Choi, Joan A Culpepper-Morgan
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
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