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Gastroenterology

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https://www.readbyqxmd.com/read/30227109/surveillance-for-early-stage-hepatocellular-carcinoma-by-ultrasound-plus-alpha-fetoprotein-measurement-more-details-more-significance
#1
LETTER
Xiu-Ping Zhang, Kang Wang, Shu-Qun Cheng
No abstract text is available yet for this article.
September 15, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30227108/bezlotoxumab-for-clostridium-difficile-infection-complicating-inflammatory-bowel-disease
#2
LETTER
Ciarán P Kelly, Mark H Wilcox, Henning Glerup, Nazimuddin Aboo, Misoo C Ellison, Karen Eves, Mary Beth Dorr
No abstract text is available yet for this article.
September 15, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30222962/factors-associated-with-histologic-response-in-adult-patients-with-nonalcoholic-steatohepatitis
#3
Rohit Loomba, Arun J Sanyal, Kris V Kowdley, Norah Terrault, Naga P Chalasani, Manal F Abdelmalek, Arthur J McCullough, Reshma Shringarpure, Beatrice Ferguson, Lois Lee, Jianfen Chen, Alexander Liberman, David Shapiro, Brent A Neuschwander-Tetri
BACKGROUND AND AIMS: Nonalcoholic steatohepatitis (NASH) is a leading cause of liver transplantation and many trials are underway to evaluate potential therapies. The farnesoid X receptor ligand obeticholic acid in NASH treatment trial evaluated the effects of obeticholic acid vs placebo on histologic response (defined as decrease in nonalcoholic fatty liver disease activity score [NAS] by ≥2, with no worsening of fibrosis); 45% of patients had a histologic response to obeticholic acid (25 mg) and 21% had a response to placebo (P<...
September 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30222943/ponder-the-innate-immunity-in-hepatitis-b-infection
#4
LETTER
Ashish Kumar Vyas, Ankur Jindal, Nirupma Trehanpati
No abstract text is available yet for this article.
September 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30222942/therapeutic-targets-in-inflammatory-bowel-disease-are-we-getting-the-point-across
#5
LETTER
Dario R Sorrentino
No abstract text is available yet for this article.
September 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30222941/damage-to-the-gastrointestinal-tract-from-nonsteroidal-anti-inflammatory-drugs-what-about-perforations-and-the-healing-intestine
#6
LETTER
Kjetil Soreide
No abstract text is available yet for this article.
September 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30222940/does-autophagy-promote-or-protect-against-the-pathogenesis-of-pancreatitis
#7
LETTER
Shaogui Wang, Wen-Xing Ding
No abstract text is available yet for this article.
September 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30218669/detection-and-analysis-of-circulating-epithelial-cells-in-liquid-biopsies-from-patients-with-liver-disease
#8
Irun Bhan, Kelly Mosesso, Lipika Goyal, Julia Philipp, Mark Kalinich, Joseph W Franses, Melissa Choz, Rahmi Oklu, Mehmet Toner, Shyamala Maheswaran, Daniel A Haber, Andrew X Zhu, Raymond T Chung, Martin Aryee, David T Ting
Epithelial cells in the circulation (circulating epithelial cells, or CECs) are analyzed as a non-invasive method to detect cancers; we investigated whether analysis of hepatocytes in the circulation can identify patients with chronic liver disease or hepatocellular carcinoma (HCC). We previously developed a cell-sorting device to isolate CECs from patient blood samples and combined it with an mRNA analysis system to identify CECs with liver-specific markers. We tested the ability of this device to detect CECs of hepatocyte origin in blood samples from healthy individuals (n=10), patients with chronic liver disease without HCC (n=39), and patients with HCC (n=54), using immunofluorescence...
September 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30218668/full-field-optical-coherence-tomography-a-new-imaging-modality-for-rapid-on-site-evaluation-of-resected-polyps-during-colonoscopy
#9
Marine Camus, Frederic Beuvon, Maximilien Barret, Eugenie Dalimier, Hicham El Bacha, Sarah Leblanc, Romain Coriat, Stanislas Chaussade, Benoit Terris, Frederic Prat
No abstract text is available yet for this article.
September 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30218667/roles-for-interleukin-17-and-adaptive-immunity-in-pathogenesis-of-colorectal-cancer
#10
REVIEW
Christopher G Hurtado, Fengyi Wan, Franck Housseau, Cynthia L Sears
Sporadic colorectal cancer (CRC) is one of the most common and lethal cancers worldwide. The locations and functions of immune cells in the colorectal tumor microenvironment are complex and heterogeneous. T-helper (Th)1 cell-mediated responses against established colorectal tumors are associated with better outcomes of patients (time of relapse-free or overall survival), whereas Th17-cell mediated responses and production of interleukin 17A (IL17A) have been associated with worse outcomes of patients. Tumors that develop in mouse models of CRC are rarely invasive and differ in many ways from human colorectal tumors...
September 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30218666/innate-immune-cells-regulate-oncoimmunity-and-cancer-development
#11
LETTER
Ai-Ping Bai, Yuan Guo
No abstract text is available yet for this article.
September 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30217743/whole-exome-sequencing-leading-to-novel-therapeutic-discovery
#12
Konstantinos N Lazaridis, Angela C Cheung
No abstract text is available yet for this article.
September 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30217742/identification-of-genes-associated-with-hirschsprung-disease-based-on-whole-genome-sequence-analysis-and-potential-effects-on-enteric-nervous-system-development
#13
Clara Sze-Man Tang, Peng Li, Frank Pui-Ling Lai, Alexander Xi Fu, Sin-Ting Lau, Man Ting So, Kathy Nga-Chu Lui, Zhixin Li, Xuehan Zhuang, Michelle Yu, Xuelai Liu, Ngoc D Ngo, Xiaoping Miao, Xi Zhang, Bin Yi, Shaotao Tang, Xiaobing Sun, Furen Zhang, Hong Liu, Qiji Liu, Ruizhong Zhang, Hualong Wang, Liuming Huang, Xiao Dong, Jinfa Tou, Kathy Se Cheah, Wanling Yang, Zhenwei Yuan, Kevin Yuk-Lap Yip, Pak-Chung Sham, Paul Kwang-Hang Tam, Maria-Mercè Garcia-Barcelo, Elly Sau-Wai Ngan
BACKGROUND & AIMS: Hirschsprung disease, or congenital aganglionosis, is believed to be oligogenic-caused by multiple genetic factors. We performed whole-genome sequence analyses of patients with Hirschsprung disease to identify genetic factors that contribute to disease development and analyzed the functional effects of these variants. METHODS: We performed whole-genome sequence analyses of 443 patients with short-segment disease, recruited from hospitals in China and Vietnam, and 493 ethnically matched individuals without Hirschsprung disease (controls)...
September 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30217741/the-i-in-depression-how-feeding-the-immune-system-can-lead-to-behavioral-changes-in-inflammatory-conditions
#14
Adrian Gomez, Noble Ogbu, Fabio Cominelli, Maneesh Dave
No abstract text is available yet for this article.
September 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30217740/wide-area-transepithelial-sampling-in-barrett-s-esophagus-ready-for-primetime
#15
Chetan Mittal, Bashar Qumseya, Sachin Wani
No abstract text is available yet for this article.
September 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30012334/gastrointestinal-and-extra-intestinal-manifestations-of-igg4-related-disease
#16
REVIEW
Katsuyuki Miyabe, Yoh Zen, Lynn D Cornell, Govindarajan Rajagopalan, Vaidehi R Chowdhary, Lewis R Roberts, Suresh T Chari
IgG4-related disease (IgG4-RD) is a chronic relapsing multi-organ fibro-inflammatory syndrome of presumed autoimmune etiology. It is characterized by increased serum levels of IgG4 and tissue infiltration by IgG4+ cells. Increased titers of autoantibodies against a spectrum of self-antigens and response to steroids have led to its characterization as an autoimmune disease. However, the pathognomonic antigens probably differ among manifestations, and different antigens or autoantibodies produce similar immune reactions in different organs...
September 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30213555/expression-of-sting-is-increased-in-liver-tissues-from-patients-with-nafld-and-promotes-macrophage-mediated-hepatic-inflammation-and-fibrosis-in-mice
#17
Xianjun Luo, Honggui Li, Linqiang Ma, Jing Zhou, Xin Guo, Shih-Lung Woo, Ya Pei, Linda R Knight, Michael Deveau, Yanming Chen, Xiaoxian Qian, Xiaoqiu Xiao, Qifu Li, Xiangbai Chen, Yuqing Huo, Kelly McDaniel, Heather Francis, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Chaodong Wu
BACKGROUND & AIMS: Transmembrane protein 173 (TMEM173 or STING) signaling by macrophage activates the type I interferon-mediated innate immune response. The innate immune response contributes to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). We investigated wither STING regulates diet-induced in hepatic steatosis, inflammation, and liver fibrosis in mice. METHODS: Mice with disruption of Tmem173 (STINGgt ) on a C57BL/6J background, mice without disruption of this gene (controls), and mice with disruption of Tmem173 only in myeloid cells were fed a standard chow diet, a high-fat diet (HFD, 60% fat calories), or a methionine- and choline-deficient diet (MCD)...
September 10, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30205102/a-case-report-of-a-young-adult-with-progressive-bloody-diarrhea-protein-losing-enteropathy-and-extended-polyposis-coli
#18
Mariël Maria Helena Borgerink, Rinse Karel Weersma, Marijn Caroline Visschedijk
No abstract text is available yet for this article.
September 8, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30205101/severe-acute-gastrointestinal-bleed-in-a-patient-with-neurofibromatosis-type-1
#19
Laura Rotundo, Sushil Ahlawat
No abstract text is available yet for this article.
September 8, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30205100/edematous-colitis-of-an-unknown-cause-diagnosis-by-pattern-recognition
#20
Michiel Bronswijk, Gert de Hertogh, Marc Ferrante
No abstract text is available yet for this article.
September 8, 2018: Gastroenterology
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