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Gastroenterology

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https://www.readbyqxmd.com/read/29155309/prognostic-utility-of-total-68-ga-dotatate-avid-tumor-volume-in-patients-with-neuroendocrine-tumors
#1
Amit Tirosh, Georgios Z Papadakis, Corina Millo, Dima Hammoud, Samira M Sadowski, Peter Herscovitch, Karel Pacak, Stephen J Marx, Lily Yang, Pavel Nockel, Jasmine Shell, Patience Green, Xavier M Keutgen, Dhaval Patel, Naris Nilubol, Electron Kebebew
BACKGROUND & AIMS: Survival times vary among patients with neuroendocrine tumors (NETs)-even among those with the same site, stage, and grade of primary tumor. This makes it difficult to select treatment for patients with unresectable NETs, because some patients can survive decades without treatment. (68)Gallium-DOTATATE positron emission tomography with computed tomography ((68)Ga-DOTATATE PET/CT) is a sensitive imaging technique for detection of NETs. We investigated the prognostic accuracy of (68)Ga-DOTATATE PET/CT analysis of tumor volume in patients with NETs...
November 16, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29154778/viral-hepatitis-knowledge-and-treatments-for-hbv-hcv-and-associated-transplantation-and-neoplasia
#2
Kenneth E Sherman, Vijay H Shah
No abstract text is available yet for this article.
November 14, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29146523/factors-that-contribute-to-differences-in-survival-of-black-vs-white-patients-with-colorectal-cancer
#3
Helmneh M Sineshaw, Kimmie Ng, W Dana Flanders, Otis W Brawley, Ahmedin Jemal
BACKGROUND & AIMS: Previous studies reported that black vs white disparities in survival among elderly patients with colorectal cancer (CRC) were due to differences in tumor characteristics (tumor stage, grade, nodal status, and comorbidity) rather than differences in treatment. We sought to determine the sequential contribution of differences in insurance, comorbidity, tumor characteristics, and treatment receipt to the black-white survival disparity among patients with CRC in 18-64 years old...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29146521/hla-dq-gluten-tetramer-blood-test-accurately-identifies-patients-with-and-without-celiac-disease-in-absence-of-gluten-consumption
#4
Vikas K Sarna, Knut E A Lundin, Lars Mørkrid, Shuo-Wang Qiao, Ludvig M Sollid, Asbjørn Christophersen
BACKGROUND & AIMS: Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence and duodenal histology requires patients to be on gluten-containing diets. The growing number of individuals adhering to a gluten-free diet (GFD) without exclusion of celiac disease complicates its detection. HLA-DQ-gluten tetramers can be used to detect gluten-specific T cells in blood of patients with celiac disease, even if they are on a GFD...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29146520/patterns-of-resistance-associated-substitutions-in-patients-with-chronic-hcv-infection-following-treatment-with-direct-acting-antivirals
#5
Julia Dietz, Simone Susser, Johannes Vermehren, Kai-Henrik Peiffer, Georgios Grammatikos, Annemarie Berger, Peter Ferenci, Maria Buti, Beat Müllhaupt, Bela Hunyady, Holger Hinrichsen, Stefan Mauss, Jörg Petersen, Peter Buggisch, Gisela Felten, Dietrich Hüppe, Gaby Knecht, Thomas Lutz, Eckart Schott, Christoph Berg, Ulrich Spengler, Thomas von Hahn, Thomas Berg, Stefan Zeuzem, Christoph Sarrazin
BACKGROUND & AIMS: Little is known about substitutions that mediate resistance of HCV to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. METHODS: We performed a comprehensive analysis for resistance-associated substitutions (RASs) in HCV genes (NS3, NS5A, NS5B) targeted by DAAs. We compared NS3, NS5A, and NS5B sequences from 626 patients in Europe with DAA failure with sequences from 2322 DAA-naïve patients, infected with HCV genotypes 1-4...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29146522/germline-genetic-features-of-young-individuals-with-colorectal-cancer
#6
Elena M Stoffel, Erika Koeppe, Jessica Everett, Peter Ulintz, Mark Kiel, Jenae Osborne, Linford Williams, Kristen Hanson, Stephen B Gruber, Laura S Rozek
BACKGROUND & AIMS: The incidence of colorectal cancer (CRC) in individuals younger than 50 years old is increasing. We sought to ascertain the proportion of young CRC cases associated with genetic predisposition. METHODS: We performed a retrospective study of individuals diagnosed with CRC at an age younger than 50 years, evaluated by the clinical genetics service at a single tertiary care cancer center from 1998 through 2015. We collected data on patient histories, tumor phenotypes, and results of germline DNA sequencing...
November 12, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29133078/enteric-delivery-of-regenerating-family-member-3-alpha-alters-the-intestinal-microbiota-and-controls-inflammation-in-mice-with-colitis
#7
Marion Darnaud, Alexandre Dos Santos, Patrick Gonzalez, Sandrine Augui, Claire Lacoste, Christophe Desterke, Gert De Hertogh, Emma Valentino, Emilie Braun, Jinzi Zheng, Raphael Boisgard, Christel Neut, Laurent Dubuquoy, Franck Chiappini, Didier Samuel, Patricia Lepage, Francesca Guerrieri, Joel Doré, Christian Bréchot, Nicolas Moniaux, Jamila Faivre
BACKGROUND & AIMS: Paneth cell dysfunction causes deficiencies in intestinal C-type lectins and antimicrobial peptides, which leads to dysbiosis of the intestinal microbiota, alters the mucosal barrier, and promotes development of inflammatory bowel diseases. We investigated whether transgenic expression of the human regenerating family member 3 alpha gene (REG3A) alters the fecal microbiota and affects development of colitis in mice. METHODS: We performed studies with C57BL/6 mice that express human regenerating family member 3 alpha (hREG3A) in hepatocytes, via the albumin gene promoter...
November 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29129714/non-invasive-diagnosis-of-pancreatic-cancer-through-detection-of-volatile-organic-compounds-in-urine
#8
Ramesh Arasaradnam, Alfian Wicaksono, Harrison O'Brien, Hemant M Kocher, James A Covington, Tatjana Crnogorac-Jurcevic
No abstract text is available yet for this article.
November 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29128318/the-75-th-diamond-anniversary-of-gastroenterology-1943-2018
#9
Richard M Peek, Douglas A Corley
No abstract text is available yet for this article.
November 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29127773/the-sentinel-bleed
#10
Mena M Bakhit, Marcos Lepe, Edward Pensa
No abstract text is available yet for this article.
November 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29122547/low-dose-aspirin-use-does-not-increase-survival-in-2-independent-population-based-cohorts-of-patients-with-esophageal-or-gastric-cancer
#11
Andrew D Spence, John Busby, Brian T Johnston, John A Baron, Carmel M Hughes, Helen G Coleman, Chris R Cardwell
BACKGROUND & AIMS: Pre-clinical studies have shown aspirin to have anti-cancer properties and epidemiologic studies have associated aspirin use with longer survival times of patients with cancer. We studied 2 large cohorts to determine the association between aspirin use and cancer-specific mortality in patients with esophageal or gastric cancer. METHODS: We performed a population-based study using cohorts of patients newly diagnosed with esophageal or gastric cancer, identified from cancer registries in England from 1998 through 2012 and the Scottish Cancer Registry from 2009 through 2012...
November 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29122546/no-increase-in-risk-of-acute-myocardial-infarction-in-privately-insured-adults-prescribed-proton-pump-inhibitors-vs-histamine-2-receptor-antagonists-2002-2014
#12
Suzanne N Landi, Robert S Sandler, Virginia Pate, Jennifer L Lund
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) are commonly used medications. Recent studies reported an increased risk of acute myocardial infarction (MI) in PPI users vs non-users. We evaluated MI risk associated with PPIs compared with histamine-2 receptor antagonists (H2RAs) in privately insured adults in the United States. METHODS: Using administrative claims from commercial and Medicare Supplemental plans (2001-2014), we compared risk of MI in patients who started a new prescription for PPIs vs H2RAs...
November 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29122545/portal-hypertension-and-unexplained-diarrhea-in-an-80-year-old-man
#13
Danse Bi, Thomas M Malikowski, Seth Sweetser
No abstract text is available yet for this article.
November 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29122544/population-health-management-for-inflammatory-bowel-disease
#14
REVIEW
Parambir S Dulai, Siddharth Singh, Lucilla Ohno-Machado, William J Sandborn
Inflammatory bowel diseases (IBD) are chronic and impose significant, multi-dimensional burdens on patients and healthcare systems. The increasing prevalence of IBD will only worsen this problem globally-population health management (PHM) strategies are needed to increase quality of care and population health outcomes while reducing healthcare costs. We discuss the key components of PHM in IBD. Effective implementation of PHM strategies requires accurate identification of at-risk patients and of key areas of variability in care...
November 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29122543/dense-mysterious-small-balls-in-the-abdomen
#15
Biao Wang, Heng Zhang
No abstract text is available yet for this article.
November 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29113809/mir21-drives-resistance-to-heat-shock-protein-90-inhibition-in-cholangiocarcinoma
#16
Andrea Lampis, Pietro Carotenuto, Georgios Vlachogiannis, Luciano Cascione, Somaieh Hedayat, Rosemary Burke, Paul Clarke, Else Bosma, Michele Simbolo, Aldo Scarpa, Sijia Yu, Rebecca Cole, Elizabeth Smyth, Javier Fernández Mateos, Ruwaida Begum, Blanka Hezelova, Zakaria Eltahir, Andrew Wotherspoon, Nicos Fotiadis, Maria Antonietta Bali, Chirag Nepal, Khurum Khan, Mark Stubbs, Jens C Hahne, Pierluigi Gasparini, Vincenza Guzzardo, Carlo M Croce, Suzanne Eccles, Matteo Fassan, David Cunningham, Jesper B Andersen, Paul Workman, Nicola Valeri, Chiara Braconi
BACKGROUND & AIMS: Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We investigated whether miRNA21 mediates resistance of CCA cells and organoids to HSP90 inhibitors. METHODS: We performed a high-throughput screen of 484 small molecule compounds to identify those that reduced viability of 6 human CCA cell lines...
November 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29112833/pancreatic-fusion-abnormality-found-during-a-whipple-procedure
#17
Bin Zhang, Xiao-Jun Yang, Zhu-Yin Qian
No abstract text is available yet for this article.
November 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29112832/a-novel-cause-of-rectal-hemorrhage-in-the-intensive-care-unit
#18
Daniel Glass, Ali Al-Khafaji
No abstract text is available yet for this article.
November 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29112831/reply
#19
LETTER
Miriam Juárez, Cecilia Egoavil, Rodrigo Jover
No abstract text is available yet for this article.
November 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29112830/a-liver-full-of-stars-hepatostellular
#20
Shelly Kakar, Amir A Borhani, Shahid M Malik
No abstract text is available yet for this article.
November 4, 2017: Gastroenterology
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