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Gastroenterology

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https://www.readbyqxmd.com/read/28082079/x-box-binding-protein-1-regulates-unfolded-protein-acute-phase-and-dna-damage-responses-during-regeneration-of-mouse-liver
#1
Josepmaria Argemí, Theresia R Kress, Haisul Cy Chang, Cristina Bértolo, Roberto Ferrero, Haritz Moreno, Manuela González-Aparicio, Rubén Hernández-Alcoceba, Victor Segura, Iker Uriarte, Laura Guembe, Matias A Avila, Bruno Amati, Jesús Prieto, Tomás Aragón
BACKGROUND & AIMS: Liver regeneration after partial hepatectomy increases the protein folding burden at the endoplasmic reticulum (ER) of remnant hepatocytes, resulting in induction of the unfolded protein response (UPR). We investigated the role of the core UPR transcription factor X-box binding protein 1 (XBP1) in liver regeneration using genome-wide chromatin immunoprecipitation analysis. METHODS: We performed studies with C57Bl6-J (control) and interleukin 6 (IL6)-knockout mice...
January 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28069350/prevalence-risk-factors-and-outcomes-of-irritable-bowel-syndrome-after-infectious-enteritis-a-systematic-review-and-meta-analysis
#2
Fabiane Klem, Akhilesh Wadhwa, Larry Prokop, Wendy Sundt, Gianrico Farrugia, Michael Camilleri, Siddharth Singh, Madhusudan Grover
BACKGROUND & AIMS: Foodborne illness affects 15% of the United States population each year and is a risk factor for irritable bowel syndrome (IBS). We evaluated risk of, risk factors for, and outcomes of IBS after infectious enteritis METHODS: We performed a systematic review of electronic databases from 1994 through August 31, 2015 to identify cohort studies of the prevalence of IBS 3 months or more after infectious enteritis. We used random effects meta-analysis to calculate the summary point prevalence of IBS after infectious enteritis, as well as relative risk (compared to individuals without infectious enteritis) and host- and enteritis-related risk factors...
January 6, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28065789/choline-kinase-alpha-mediates-interactions-between-the-epidermal-growth-factor-receptor-and-mtorc2-in-hepatocellular-carcinoma-cells-to-promote-drug-resistance-and-xenograft-tumor-progression
#3
Xi-Meng Lin, Liang Hu, Jin Gu, Ruo-Yu Wang, Liang Li, Jing Tang, Bao-Hua Zhang, Xing-Zhou Yan, Yan-Jing Zhu, Cong-Li Hu, Wei-Ping Zhou, Shao Li, Jing-Feng Liu, Frank J Gonzalez, Meng-Chao Wu, Hong-Yang Wang, Lei Chen
BACKGROUND & AIMS: Choline kinase alpha (CHKA) catalyzes conversion of choline to phosphocholine and can contribute to carcinogenesis. Little is known about the role of CHKA in the pathogenesis of hepatocellular carcinoma (HCC). METHODS: We performed whole-exome and transcriptome sequence analyses of 9 paired HCC and non-tumor adjacent tissues. We performed tissue chip analyses of 120 primary HCC and non-tumor adjacent tissues from patients who received surgery in Shanghai, China from January 2006 through December 2009; 48 sets of specimens (HCC and non-tumor adjacent tissues) were also analyzed...
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28065788/western-dietary-pattern-increases-whereas-prudent-dietary-pattern-decreases-risk-of-incident-diverticulitis-in-a-prospective-cohort-study
#4
Lisa L Strate, Brieze R Keeley, Yin Cao, Kana Wu, Edward L Giovannucci, Andrew T Chan
BACKGROUND & AIMS: Dietary fiber is implicated as a risk factor for diverticulitis. Analyses of dietary patterns may provide information on risk beyond those of individual foods or nutrients. We examined whether major dietary patterns are associated with risk of incident diverticulitis. METHODS: We performed a prospective cohort study of 46,295 men who were free of diverticulitis and known diverticulosis in 1986 (baseline) using data from the Health Professionals Follow-up Study...
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28065787/intestinal-farnesoid-x-receptor-controls-transintestinal-cholesterol-excretion-in-mice
#5
Jan Freark de Boer, Marleen Schonewille, Marije Boesjes, Henk Wolters, Vincent W Bloks, Trijnie Bos, Theo H van Dijk, Angelika Jurdzinski, Renze Boverhof, Justina C Wolters, Jan A Kuivenhoven, Jan M van Deursen, Ronald P J Oude Elferink, Antonio Moschetta, Claus Kremoser, Henkjan J Verkade, Folkert Kuipers, Albert K Groen
BACKGROUND & AIMS: The role of the intestine in the maintenance of cholesterol homeostasis is increasingly recognized. Fecal excretion of cholesterol is the last step in the atheroprotective reverse cholesterol transport pathway, to which biliary and transintestinal cholesterol excretion (TICE) contribute. The mechanisms controlling the flux of cholesterol through the TICE pathway are, however, poorly understood. We aimed to identify mechanisms that regulate and stimulate TICE. METHODS: We performed studies with C57Bl/6J mice, as well as mice with intestine-specific knockout of the farnesoid X receptor (FXR), mice that express an FXR transgene specifically in the intestine, and ABCG8-knockout mice...
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28063818/a-rare-endoscopic-clue-to-a-common-clinical-condition
#6
Bradley Anderson, Seth Sweetser
No abstract text is available yet for this article.
January 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28063956/differentiation-of-mouse-enteric-nervous-system-progenitor-cells-is-controlled-by-endothelin-3-and-requires-regulation-of-ednrb-by-sox10-and-zeb2
#7
Yuli Watanabe, Laure Stanchina, Laure Lecerf, Nadjet Gacem, Andrea Conidi, Viviane Baral, Veronique Pingault, Danny Huylebroeck, Nadege Bondurand
BACKGROUND & AIMS: Maintenance and differentiation of progenitor cells in the developing enteric nervous system (ENS) are controlled by molecules such as the signaling protein endothelin 3 (EDN3), its receptor (the endothelin receptor type B, EDNRB), and the transcription factors SRY-box 10 (SOX10) and zinc finger E-box binding homeobox 2 (ZEB2). We used enteric progenitor cell (EPC) cultures and mice to study the roles of these proteins in enteric neurogenesis and their cross regulation...
January 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28063955/asymptomatic-carriers-contribute-to-nosocomial-clostridium-difficile-infection-a-cohort-study-of-4508-patients
#8
Thomas Blixt, Kim Oren Gradel, Christian Homann, Jakob Benedict Seidelin, Kristian Schønning, Anne Lester, Jette Houlind, Marie Stangerup, Magnus Gottlieb, Jenny Dahl Knudsen
BACKGROUND & AIMS: Nosocomial infection with Clostridium difficile pose a considerable problem despite numerous attempts by health care workers to reduce risk of transmission. Asymptomatic carriers of C difficile might spread their infection to other patients. We investigated the effects of of asymptomatic carriers on nosocomial C difficile infections. METHODS: We performed a population-based prospective cohort study at 2 university hospitals in Denmark, screening all patients for toxigenic C difficile in the intestine upon admittance, from October 1, 2012, to January 31, 2013...
January 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28063287/clinical-practice-guidelines-for-the-use-of-video-capsule%C3%A2-endoscopy
#9
Robert A Enns, Lawrence Hookey, David Armstrong, Charles N Bernstein, Steven J Heitman, Christopher Teshima, Grigorios I Leontiadis, Frances Tse, Daniel Sadowski
BACKGROUND & AIMS: Video capsule endoscopy (CE) provides a noninvasive option to assess the small intestine, but its use with respect to endoscopic procedures and cross-sectional imaging varies widely. The aim of this consensus was to provide guidance on the appropriate use of CE in clinical practice. METHODS: A systematic literature search identified studies on the use of CE in patients with Crohn's disease, celiac disease, gastrointestinal bleeding, and anemia...
January 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28063286/a-rare-cause-of-colonic-stricture
#10
Vu Q Nguyen, Douglas J Grider, Paul Yeaton
No abstract text is available yet for this article.
January 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28063285/spontaneous-self-expulsion-of-a-large-stone-from-the-abdomen
#11
Kherru Sarah Sim, Chung Yip Chan, Ser Yee Lee
No abstract text is available yet for this article.
January 4, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28062202/commentary-on-2016-multi-society-task-force-endoscope-reprocessing-guidelines
#12
Susan M Hutfless, Anthony N Kalloo
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28061340/an-unusual-case-of-cholangitis
#13
Ming-Chang Ku, Pei-Yu Lee, Victor C Kok
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28061339/how-to-perform-high-quality-endoscopic-mucosal-resection-during-colonoscopy
#14
Amir Klein, Michael J Bourke
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28061338/american-gastroenterology-association-institute-technical-review-on-initial-testing-and-management-of-acute-liver-disease
#15
Steven K Herrine, Paul Moayyedi, Robert S Brown, Yngve T Falck-Ytter
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28061337/an-unusual-painless-groin-mass-in-an-elderly-man
#16
Chung-Liang Chiang, Zheng-Yi Huang, Bao-Chung Chen
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28061336/a-rare-cause-of-massive-gastrointestinal-bleeding
#17
Rafael Noronha Cavalcante, Fernanda Uchiyama, Francisco Cesar Carnevale
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28061335/covering-the-cover
#18
Andrew T Chan, Christopher S Williams
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28056353/abdominal-pain-after-colonoscopy
#19
Derek J Erstad, Leandre S Krowsoski, Haytham M A Kaafarani
No abstract text is available yet for this article.
January 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28056352/painful-perineal-mass-what-is-the-diagnosis
#20
Niccolo' Petrucciani, Tarek Debs, Jean Gugenheim
No abstract text is available yet for this article.
January 2, 2017: Gastroenterology
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