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Gastroenterology

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https://www.readbyqxmd.com/read/30031138/incidence-of-hepatocellular-carcinoma-after-direct-antiviral-therapy-for-hcv-in-patients-with-cirrhosis-included-in-surveillance-programs
#1
Pierre Nahon, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino, Angela Sutton, Françoise Roudot-Thoraval, Etienne Audureau
BACKGROUND & AIMS: Retrospective studies have found an unexpectedly high incidence of hepatocellular carcinoma (HCC) among patients with hepatitis C virus (HCV)-associated cirrhosis who received direct-acting antiviral (DAA) agents. We analyzed data from the ANRS CO12 CirVir cohort to compare the incidence of HCC in patients with cirrhosis who received DAA therapy vs patients treated with interferon (IFN). METHODS: Data were collected from 1270 patients with compensated biopsy-proven HCV-associated cirrhosis recruited from 2006 through 2012 at 35 centers in France...
July 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30031137/a-mysterious-calcified-target-lesion-causing-gastrointestinal-bleeding
#2
Muhamad Alhaj Moustafa, Ammar Alhaj Moustafa, Sherif Elmahdy
No abstract text is available yet for this article.
July 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30031136/an-82-year-old-man-with-vague-abdominal-pain-and-weakness
#3
Gregory Pajot, Barham Abu Dayyeh, Karthik Ravi
No abstract text is available yet for this article.
July 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30031135/a-middle-aged-male-with-jaundice-and-a-gastric-tumor
#4
Tom J Harryvan, L M Morsink, Maarten E Tushuizen
No abstract text is available yet for this article.
July 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30031134/-a-sweet-discovery
#5
António Correia-Varela-Almeida, Åke Öst, Francisco Baldaque-Silva
No abstract text is available yet for this article.
July 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30031133/in-god-we-trust-and-for-all-the-rest-we-need-pathology
#6
Alexander Vanden Bulcke, Marie Keuppens, Guido Deboever
No abstract text is available yet for this article.
July 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30025705/new-onset-villous-atrophy-in-a-patient-with-celiac-disease
#7
Amanda K Cartee, Juan P Reyes Genere, Amy S Oxentenko
No abstract text is available yet for this article.
July 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30025704/inhibiting-growth-of-clostridioides-difficile-by-restoring-valerate-produced-by-the-intestinal-microbiota
#8
Julie A K McDonald, Benjamin H Mullish, Alexandros Pechlivanis, Zhigang Liu, Jerusa Brignardello, Dina Kao, Elaine Holmes, Jia V Li, Thomas B Clarke, Mark R Thursz, Julian R Marchesi
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) is effective for treating recurrent Clostridioides difficile infection (CDI), but there are concerns about its long-term safety. Understanding the mechanisms of the effects of FMT could help us design safer, targeted therapies. We aimed to identify microbial metabolites that are important for C difficile growth. METHODS: We used a CDI chemostat model as a tool to study the effects of FMT in vitro. The following analyses were performed: C difficile plate counts, 16S rRNA gene sequencing, 1 H-NMR spectroscopy, and UPLC mass spectrometry bile acid profiling...
July 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30012334/gastrointestinal-and-extra-intestinal-manifestations-of-immunoglobulin-g4-related-disease
#9
REVIEW
Katsuyuki Miyabe, Yoh Zen, Lynn D Cornell, Govindarajan Rajagopalan, Vaidehi R Chowdhary, Lewis R Roberts, Suresh T Chari
Immunoglobulin G4-related disease (IgG4-RD) is a chronic relapsing multi-organ fibro-inflammatory syndrome of presumed autoimmune etiology. It is characterized by increased serum levels of IgG subclass 4 (IgG4) and tissue infiltration by IgG4+ cells. Increased titers of autoantibodies against a spectrum of self-antigens and response to steroids have led to its characterization as an autoimmune disease. However, the pathognomonic antigens probably differ among manifestations, and different antigens or autoantibodies produce similar immune reactions in different organs...
July 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30012333/mitochondrial-dysfunction-and-signaling-in-chronic-liver-diseases
#10
REVIEW
Abdellah Mansouri, Charles-Henry Gattolliat, Tarik Asselah
Mitochondria regulate hepatic lipid metabolism and oxidative stress. Ultrastructural mitochondrial lesions, altered mitochondrial dynamics, decreased activity of respiratory chain complexes, and impaired ability to synthesize ATP are observed in liver tissues from patients with alcohol-associated and non-associated liver diseases. Increased lipogenesis with decreased fatty acid β-oxidation leads to the accumulation of triglycerides in hepatocytes, which, combined with increased levels of reactive oxygen species, contributes to insulin resistance in patients with steatohepatitis...
July 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30009820/overexpression-of-rac-gtpase-activating-protein-1-contributes-to-proliferation-of-cancer-cells-by-reducing-hippo-signaling-to-promote-cytokinesis
#11
Xiao-Mei Yang, Xiao-Yan Cao, Ping He, Jun Li, Ming-Xuan Feng, Yan-Li Zhang, Xue-Li Zhang, Ya-Hui Wang, Qin Yang, Lei Zhu, Hui-Zhen Nie, Shu-Heng Jiang, Guang-Ang Tian, Xiao-Xin Zhang, Qiang Liu, Jianguang Ji, Xuefeng Zhu, Qiang Xia, Zhi-Gang Zhang
BACKGROUND & AIMS: Agents designed to block or alter cytokinesis can kill or stop proliferation of cancer cells. We aimed to identify cytokinesis-related proteins that are overexpressed in hepatocellular carcinoma (HCC) cells and might be targeted to slow liver tumor growth. METHODS: Using the Oncomine database, we compared the gene expression patterns in 16 cancer microarray datasets and assessed gene enrichment sets using Gene Ontology. We performed immunohistochemical analysis of an HCC tissue microarray and identified changes in protein levels that associated with patient survival times...
July 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30009819/updated-international-consensus-diagnostic-criteria-for-eosinophilic-esophagitis-proceedings-of-the-agree-conference
#12
Evan S Dellon, Chris A Liacouras, Javier Molina-Infante, Glenn T Furuta, Jonathan M Spergel, Noam Zevit, Stuart J Spechler, Stephen E Attwood, Alex Straumann, Seema S Aceves, Jeffrey A Alexander, Dan Atkins, Nicoleta C Arva, Carine Blanchard, Peter A Bonis, Wendy M Book, Kelley E Capocelli, Mirna Chehade, Edaire Cheng, Margaret H Collins, Carla M Davis, Jorge A Dias, Carlo Di Lorenzo, Ranjan Dohil, Christophe Dupont, Gary W Falk, Cristina T Ferreira, Adam Fox, Nirmala P Gonsalves, Sandeep K Gupta, David A Katzka, Yoshikazu Kinoshita, Calies Menard-Katcher, Ellyn Kodroff, David C Metz, Stephan Miehlke, Amanda B Muir, Vincent A Mukkada, Simon Murch, Samuel Nurko, Yoshikazu Ohtsuka, Rok Orel, Alexandra Papadopoulou, Kathryn A Peterson, Hamish Philpott, Philip E Putnam, Joel E Richter, Rachel Rosen, Marc E Rothenberg, Alain Schoepfer, Melissa M Scott, Neil Shah, Javed Sheikh, Rhonda F Souza, Mary J Strobel, Nicholas J Talley, Michael F Vaezi, Yvan Vandenplas, Mario C Vieira, Marjorie M Walker, Joshua B Wechsler, Barry K Wershil, Ting Wen, Guang-Yu Yang, Ikuo Hirano, Albert J Bredenoord
BACKGROUND AND AIMS: Over the last decade, clinical experiences and research studies raised concerns regarding use of proton pump inhibitors (PPIs) as part of the diagnostic strategy for eosinophilic esophagitis (EoE). We aimed to clarify the use of PPIs in the evaluation and treatment of children and adults with suspected EoE in order to develop updated international consensus criteria for EoE diagnosis. METHODS: A consensus conference was convened to address the issue of PPI use for esophageal eosinophilia using a process consistent with standards described in the Appraisal of Guidelines for Research and Evaluation II...
July 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30009818/cpg-island-methylation-in-sessile-serrated-adenomas-increases-with-age-indicating-lower-risk-of-malignancy-in-young-patients
#13
Cheng Liu, Mark L Bettington, Neal I Walker, Joel Dwine, Gunter F Hartel, Barbara A Leggett, Vicki L J Whitehall
Among sessile serrated adenomas (SSAs) with identical histologic features, some never progress whereas others become dysplastic and develop into invasive cancers. Development of the CpG island methylator phenotype (CIMP) is a feature of SSA progression; we examined the CIMP status of 448 SSAs and examined the association with patient outcomes. Overall 190 SSAs were CIMP positive. CIMP positivity was associated with older patient age (P<.001) and proximal polyp site (P<.001), but not with patient sex (P=...
July 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30009817/rome-foundation-working-team-report-on-post-infection-irritable-bowel-syndrome
#14
Giovanni Barbara, Madhusudan Grover, Premysl Bercik, Maura Corsetti, Uday C Ghoshal, Lena Ohman, Mirjana Rajilić-Stojanović
BACKGROUND & AIMS: The existence of post-infection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team report was to summarize the available evidence on the pathophysiology of PI-IBS and provide guidance for diagnosis and treatment, based upon findings reported in the literature and clinical experience...
July 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30009816/changing-trends-in-etiology-based-annual-mortality-from-chronic-liver-disease-from-2007-through-2016
#15
Donghee Kim, Andrew A Li, Chiranjeevi Gadiparthi, Muhammad Ali Khan, George Cholankeril, Jeffrey S Glenn, Aijaz Ahmed
BACKGROUND & AIMS: Although treatment of hepatitis C virus (HCV) infection has improved, the prevalence of alcoholic liver disease (ALD) has been increasing, so we need an updated estimate of the burden and etiology-specific mortality of chronic liver diseases. We studied the trends in age-standardized mortality of chronic liver diseases among adults 20 years or older in the United States (US), from 2007 through 2016. METHODS: We collected data from the US Census and National Center for Health Statistics mortality records, identifying individuals with HCV infection, ALD, nonalcoholic fatty liver disease (NAFLD), or hepatitis B virus (HBV) infection using ICD-10 codes...
July 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30009815/fermentable-sugar-ingestion-gas-production-and-gastrointestinal-and-central-nervous-system-symptoms-in-patients-with-functional-disorders
#16
Clive H Wilder-Smith, Søren S Olesen, Andrea Materna, Asbjørn M Drewes
BACKGROUND & AIMS: Functional gastrointestinal disorders (FGID) are defined by broad phenotypic descriptions and exclusion of recognizable disease. FGIDs cause multi-organ symptoms and abnormal results in a wide range of laboratory tests, indicating broad mechanisms of pathogenesis. Many patients with FGID develop symptoms following ingestion of fermentable sugars; we investigated the associations between symptoms and intestinal gas production following sugar provocation tests, to elucidate mechanisms of FGID...
July 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30003886/new-onset-hematochezia-in-a-post-transplant-patient
#17
Cassandra Gandle, Vinshi Khan, Suneal Agarwal
No abstract text is available yet for this article.
July 9, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30001991/pulmonary-arterial-hypertension-associated-with-the-chinese-herb-indigo-naturalis-for-ulcerative-colitis-it-may-be-reversible
#18
LETTER
Mayu Nishio, Keiji Hirooka, Yasuji Doi
No abstract text is available yet for this article.
July 9, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29990488/simtuzumab-is-ineffective-for-patients-with-bridging-fibrosis-or-compensated-cirrhosis-caused-by-nonalcoholic-steatohepatitis
#19
Stephen A Harrison, Manal F Abdelmalek, Stephen Caldwell, Mitchell L Shiffman, Anna Mae Diehl, Reem Ghalib, Eric J Lawitz, Don C Rockey, Raul Aguilar Schall, Catherine Jia, Bryan J McColgan, John G McHutchison, G Mani Subramanian, Robert P Myers, Zobair Younossi, Vlad Ratziu, Andrew J Muir, Nezam H Afdhal, Zachary Goodman, Jaime Bosch, Arun J Sanyal
BACKGROUND & AIMS: Lysyl oxidase like 2 (LOXL2) contributes to fibrogenesis by catalyzing cross linkage of collagen. We evaluated the safety and efficacy of simtuzumab, a monoclonal antibody against LOXL2, in a phase 2b trial of patients with advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). METHODS: We performed a double-blind study of 219 patients with bridging fibrosis, caused by NASH, randomly assigned (1:1:1) to groups given weekly subcutaneous injections of simtuzumab (75 or 125 mg) or placebo for a planned duration of 240 weeks...
July 7, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29990487/prevalence-of-antibiotic-resistance-in-helicobacter-pylori-a-systematic-review-and-meta-analysis-in-world-health-organization-regions
#20
Alessia Savoldi, Elena Carrara, David Y Graham Prof, Michela Conti, Evelina Tacconelli
BACKGROUND & AIMS: In 2017, the World Health Organization (WHO) designated clarithromycin-resistant Helicobacter pylori a high priority for antibiotic research and development. However, there are no clear data on the global distribution of resistance or its clinical effects. We performed a systematic review and meta-analysis to assess the distribution of H pylori resistance to commonly used antibiotics and to measure the association between antibiotic resistance and treatment failure...
July 7, 2018: Gastroenterology
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