Junya Arai, Yoku Hayakawa, Hiroaki Tateno, Keita Murakami, Takeru Hayashi, Masahiro Hata, Yuki Matsushita, Hiroto Kinoshita, Sohei Abe, Ken Kurokawa, Yukiko Oya, Mayo Tsuboi, Sozaburo Ihara, Ryota Niikura, Nobumi Suzuki, Yusuke Iwata, Toshiro Shiokawa, Chihiro Shiomi, Chie Uekura, Keisuke Yamamoto, Hiroaki Fujiwara, Satoshi Kawamura, Hayato Nakagawa, Seiya Mizuno, Takashi Kudo, Satoru Takahashi, Tetsuo Ushiku, Yoshihiro Hirata, Chifumi Fujii, Jun Nakayama, Shinsuke Shibata, Susan Woods, Daniel L Worthley, Masanori Hatakeyama, Timothy C Wang, Mitsuhiro Fujishiro
BACKGROUND: Gastric cancer is often accompanied by a loss of MUC6, but its pathogenic role in gastric carcinogenesis remains unclear. METHOD: Muc6 knockout (Muc6-/-) mice and Muc6-dsRED mice were newly generated. Tff1Cre, Golph3-/-, R26-Golgi-mCherry, Hes1flox/flox , Cosmcflox/flox , A4gnt-/- mice were also used. Histology, DNAs and RNAs, proteins, and sugar chains were analyzed by whole exon DNA sequence, RNA sequence, immunohistochemistry, lectin-binding assays, and LC-MS analysis...
April 5, 2024: Gastroenterology