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Fertility and Sterility

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Although there is currently no definitive evidence linking West Nile virus (WNV) transmission with reproductive cells, it is recommended that practitioners defer gamete donors who have confirmed or suspected WNV infections. This document replaces the previously published document of the same name, last published in 2016 (Fertil Steril 2016;105:e9-10).
October 2018: Fertility and Sterility
Artur Ludwin, Inga Ludwin, Bala Bhagavath, Wellington P Martins, Steven R Lindheim
OBJECTIVES: To demonstrate the hymen-sparing management of a blind hemivagina in obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome with the use of transrectal ultrasound (TRUS)-guided vaginoscopic septoplasty supported by pre- and postoperative diagnostics with the use of a novel ultrasound technique: 3-dimensional saline-solution infusion contrast sonovaginocervicography (3D-SVC) with virtual speculoscopy. DESIGN: Video presentation of surgical and ultrasound techniques...
October 2018: Fertility and Sterility
Henri Azaïs, Charles-Henri Canova, Elie Vesale, Jean-Marc Simon, Geoffroy Canlorbe, Catherine Uzan
OBJECTIVE: To describe a surgical technique for laparoscopic uterine fixation (LUF) to decrease uterine radiation therapy side effects in case of rectal or anal cancer. DESIGN: This video article uses a surgical case to demonstrate the detailed technique. Institutional Review Board approval was not required for this video presentation. SETTING: University hospital. PATIENT(S): A 26-year-old nulliparous female patient diagnosed with rectal adenocarcinoma and liver metastases...
October 2018: Fertility and Sterility
Martha Hickey, Lauren P Lawson, Jennifer L Marino, Jeffrey A Keelan, Roger Hart
OBJECTIVE: To study the role of the prenatal environment in regulating reproductive development by measuring the prospective association between umbilical cord concentrations of sex hormone binding globulin (SHBG; principal regulator of sex steroid activity), bioavailable sex steroids, and age at menarche. DESIGN: Prospective population-based cohort. SETTING: Not applicable. PATIENT(S): In 286 female members of the Western Australian Pregnancy (Raine) cohort, concentrations of SHBG and steroids (estrogens: estrone, estradiol, estriol and estetrol [E4]; androgens: total testosterone, Δ4-androstenedione, androstenedione and dehydroepiandrosterone) were measured by liquid chromatography-tandem mass spectrometry from archived umbilical cord blood samples collected at birth...
October 2018: Fertility and Sterility
Tina Tellum, Staale Nygaard, Else K Skovholt, Erik Qvigstad, Marit Lieng
OBJECTIVE: To develop a multivariate prediction model for diagnosing adenomyosis using predictors available through transvaginal ultrasonography and clinical examinations. DESIGN: Prospective observational single-center study. SETTING: Teaching university hospital. PATIENT(S): One hundred consecutively enrolled premenopausal women aged 30-50 years, undergoing hysterectomy due to a benign condition and not using hormonal treatment...
October 2018: Fertility and Sterility
Lei Zhan, Shun Yao, Shiying Sun, Qian Su, Jun Li, Bing Wei
OBJECTIVE: To investigate the levels of NLRC5 and autophagy in women with leiomyoma and endometriosis and the correlation between NLRC5 level and autophagy level. DESIGN: Case-control study. SETTING: Clinics. PATIENT(S): Sixty-five patients were recruited: 30 women with endometriosis were compared with 35 women with leiomyoma. INTERVENTION(S): Endometriosis was definitively diagnosed during surgery by laparoscopy or laparotomy and was confirmed by histopathological evaluation (n=30)...
October 2018: Fertility and Sterility
Pietro Santulli, Chloe Tran, Vanessa Gayet, Mathilde Bourdon, Chloe Maignien, Louis Marcellin, Khaled Pocate-Cheriet, Charles Chapron, Dominique de Ziegler
OBJECTIVE: To study the prevalence of oligo-anovulation in women suffering from endometriosis compared to that of women without endometriosis. DESIGN: A single-center, cross-sectional study. SETTING: University hospital-based research center. PATIENT (S): We included 354 women with histologically proven endometriosis and 474 women in whom endometriosis was surgically ruled out between 2004 and 2016. INTERVENTION: None...
October 2018: Fertility and Sterility
Ludovico Muzii, Chiara Di Tucci, Mara Di Feliciantonio, Giulia Galati, Violante Di Donato, Angela Musella, Innocenza Palaia, Pierluigi Benedetti Panici
OBJECTIVE: To evaluate if the presence of endometriomas impacts on the ovarian reserve as evaluated with antimüllerian hormone (AMH). DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Patients with unoperated endometriomas versus controls without endometriomas. INTERVENTION(S): Electronic databases searched up to June 2017 to identify articles evaluating AMH levels in patients with unoperated endometriomas versus controls without endometriomas...
October 2018: Fertility and Sterility
Simone Garzon, Ricciarda Raffaelli, Umberto Montin, Fabio Ghezzi
OBJECTIVE: To report a case of primary hepatic pregnancy complicated by acute hemoperitoneum that was treated with a laparoscopic approach. DESIGN: Case report and review of the literature. SETTING: Obstetrics and gynecology unit of a university hospital. PATIENT(S): A 37-year-old pregnant woman who presented with vaginal bleeding. INTERVENTION(S): Diagnosis by abdominal ultrasound and computed tomography...
October 2018: Fertility and Sterility
Celine Blank, Imke T Duijf, Els Slappendel, Massimo Mischi, Saskia Houterman, Jacques W M Maas, Petra de Sutter, Benedictus C Schoot
OBJECTIVE: To evaluate the multivariate embryo selection model by van Loendersloot et al. (2014) (VL) in a different geographical context. DESIGN: This is a retrospective external validation study of a 5-year cohort of women undergoing in vitro fertilization or intracytoplasmatic sperm injection. SETTING: Two outpatient fertility clinics. PATIENT(S): A total of 1,197 women who underwent 1,610 fresh in vitro fertilization or intracytoplasmatic sperm injection cycles with single embryo transfer were included...
October 2018: Fertility and Sterility
Shan Wei, Zachary R Weiss, Pallavi Gaur, Eric Forman, Zev Williams
OBJECTIVE: To determine if a handheld, nanopore-based DNA sequencer can be used for rapid preimplantation genetic screening (PGS). DESIGN: Laboratory study. SETTING: Academic medical center. PATIENT(S): Amplified genomic DNA from euploid and aneuploid trophectoderm biopsy samples (n=9) that was also tested using traditional next generation sequencing (NGS). INTERVENTION(S): Short-read DNA library preparation and nanopore-based sequencing using a hand-held MinION sequencer...
October 2018: Fertility and Sterility
Pietro Bortoletto, Malavika Prabhu, Elizabeth M Garry, Krista F Huybrechts, Raymond M Anchan, Brian T Bateman
OBJECTIVE: To study opioid dispensing patterns following oocyte retrieval. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Women undergoing oocyte retrieval with a maximum of 1 opioid prescription in the 12 weeks prior to the procedure, without an opioid use or other substance use disorder. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): We measured the frequency of opioids dispensed within 3 days of oocyte retrieval, most common opioids dispensed; and quantity dispensed, in median (interquartile range [IQR] and 10th-90th percentile ranges) oral morphine milligram equivalents (MME)...
October 2018: Fertility and Sterility
Shelby A Neal, Scott J Morin, Jason M Franasiak, Linnea R Goodman, Caroline R Juneau, Eric J Forman, Marie D Werner, Richard T Scott
OBJECTIVE: To determine if preimplantation genetic testing for aneuploidy (PGT-A) is cost-effective for patients undergoing in vitro fertilization (IVF). DESIGN: Decision analytic model comparing costs and clinical outcomes of two strategies: IVF with and without PGT-A. SETTING: Genetics laboratory. PATIENTS: Women ≤ 42 years of age undergoing IVF. INTERVENTION(S): Decision analytic model applied to the above patient population utilizing a combination of actual clinical data and assumptions from the literature regarding the outcomes of IVF with and without PGT-A...
October 2018: Fertility and Sterility
Thalia R Segal, Keewan Kim, Sunni L Mumford, James M Goldfarb, Rachel S Weinerman
OBJECTIVE: To assess the reproductive and neonatal outcomes of cycles in which donor oocyte embryos were transferred to gestational carriers compared to intended parent recipients. DESIGN: Retrospective cohort study. SETTING: Not applicable. PATIENT(S): Intended parent recipients and gestational carriers receiving donor oocyte embryos in 2014 in the United States. INTERVENTIONS(S): None. MAIN OUTCOMES MEASURE(S): Clinical pregnancy, live birth, miscarriage, plurality, prematurity, and birth weight from pregnancies conceived with donor oocyte embryos transferred to either a gestational carrier or an intended parent recipient...
October 2018: Fertility and Sterility
Antonio Capalbo, Valeria Romanelli, Cristina Patassini, Maurizio Poli, Laura Girardi, Adriano Giancani, Marta Stoppa, Danilo Cimadomo, Filippo Maria Ubaldi, Laura Rienzi
OBJECTIVE: To determine whether blastocoel fluid (BF) or spent blastocyst medium (SBM) is a suitable template for genotype and/or karyotype assessment of in vitro fertilization-generated embryos. DESIGN: Prospective blinded study. SETTING: Genetic laboratory. PATIENT(S): From 26 patients undergoing preimplantation genetic testing (PGT) treatments, 103 trophectoderms (TE), 92 BF samples, and 72 SBM samples. INTERVENTION(S): The BF and SBM were retrieved at the time of TE biopsy...
October 2018: Fertility and Sterility
Sarah M Capelouto, Zsolt Peter Nagy, Daniel B Shapiro, Sydney R Archer, Deandrea P Ellis, Alicia K Smith, Jessica B Spencer, Heather S Hipp
OBJECTIVE: To examine the degree to which paternal variables of age, body mass index (BMI), and sperm parameters affect vitrified donor oocyte IVF outcomes. Previous studies examining the impact of male partner characteristics on in-vitro fertilization (IVF) have found conflicting results. Concerns are rising over the potential effects of paternal factors, such as age and obesity, on pregnancy and child health. Frozen donor oocyte IVF offers an ideal model to study these effects. DESIGN: Retrospective chart review...
October 2018: Fertility and Sterility
Caterina Exacoustos, Errico Zupi
No abstract text is available yet for this article.
October 2018: Fertility and Sterility
Edgardo Somigliana
No abstract text is available yet for this article.
October 2018: Fertility and Sterility
Elpida Fragouli, Dagan Wells
No abstract text is available yet for this article.
October 2018: Fertility and Sterility
Tricia E Wright
No abstract text is available yet for this article.
October 2018: Fertility and Sterility
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