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Fertility and Sterility

Mingtao Huang, Meng Zhu, Tingting Jiang, Yifeng Wang, Cheng Wang, Guangfu Jin, Xuejiang Guo, Jiahao Sha, Juncheng Dai, Xiaoming Wang, Zhibin Hu
OBJECTIVE: To investigate the association between genetic variants in the major histocompatibility complex (MHC) region and nonobstructive azoospermia (NOA) susceptibility. DESIGN: MHC region fine-mapping analysis based on previous NOA genome-wide association study (GWAS) data. SETTING: Medical university. PATIENT(S): Nine hundred and eighty-one men with NOA and 1,657 normal fertile male controls. INTERVENTION(S): None...
November 28, 2018: Fertility and Sterility
Elena Labarta, Maria José de Los Santos, Sonia Herraiz, Maria José Escribá, Alicia Marzal, Anna Buigues, Antonio Pellicer
OBJECTIVE: To study if autologous mitochondrial transfer (AUGMENT) improves outcome in patients with previously failed in vitro fertilization (IVF). DESIGN: Randomized, controlled, triple-blind, experimental study. SETTING: Private infertility center, Valencian Institute of Infertility (IVI-RMA), Valencia, Spain. PATIENT(S): Infertile women ≤42 years of age, body mass index <30 kg/m2 , antimüllerian hormone ≥4 pmol/L, >5 million/mL motile sperm, at least one previous IVF with at least five metaphase oocytes (MIIs) collected, and low embryo quality...
November 24, 2018: Fertility and Sterility
Xing Yan Liu, Yun Jie Yang, Chuan Ling Tang, Kai Wang, Jun-Jiang Chen, Xiao Ming Teng, Ye Chun Ruan, Jian Zhi Yang
OBJECTIVE: To measure blood and follicular antimüllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technologies (ART) and to examine the direct action of insulin on AMH expression in human granulosa cells. DESIGN: Prospective clinical and experimental study. SETTING: University Hospital-based laboratory. PATIENT(S): Women with (n = 86) and without (n = 172) PCOS in ART...
November 23, 2018: Fertility and Sterility
Ana Corachán, Hortensia Ferrero, Alejandra Aguilar, Nuria Garcia, Javier Monleon, Amparo Faus, Irene Cervelló, Antonio Pellicer
OBJECTIVE: To assess the effect of vitamin D (VitD) on human uterine leiomyomas through Wnt/β-catenin pathway inhibition, apoptosis induction, and cell growth arrest. DESIGN: A prospective study comparing leiomyoma vs. myometrium tissues. Paired design study comparing human uterine leiomyoma primary (HULP) cells treated with or without VitD. SETTING: Hospital Universitario-Politécnico La Fe, Fundación IVI/INCLIVA, Universidad de Valencia, Valencia, Spain...
November 17, 2018: Fertility and Sterility
Jie Zhang, Yun Wang, Hongfang Liu, Xiaoyan Mao, Qiuju Chen, Yong Fan, Yitao Xiao, Yanping Kuang
OBJECTIVE: To investigate the effect of embryo culture duration on birth weight in vitrified-warmed cycles. DESIGN: Retrospective cohort study. SETTING: Tertiary-care academic medical center. PATIENT(S): A total of 4,201 women who gave birth to 3,520, 215, and 466 live-born singletons after frozen-thawed cleavage-stage (day 3) and day 5 and day 6 blastocyst transfer, respectively. INTERVENTION(S): None...
November 17, 2018: Fertility and Sterility
Jessica L Gleason, Edmond D Shenassa, Marie E Thoma
OBJECTIVE: To explore associations between infertility and metabolic syndrome, and cardiovascular events. Infertility is increasingly a public health issue, with emerging links to chronic disease. Existing literature on infertility focuses primarily on known causes, which likely excludes a substantial number of women for whom there is no known cause or formal diagnosis. DESIGN/SETTING: We conducted a cross-sectional analysis examining the association between self-reported infertility (i...
November 17, 2018: Fertility and Sterility
Eleni A Greenwood, Lauri A Pasch, Kanade Shinkai, Marcelle I Cedars, Heather G Huddleston
OBJECTIVE: To [1] characterize depression symptoms over time and [2] test the hypothesis that adverse metabolic parameters would associate with risk of enduring depression risk in women with polycystic ovary syndrome (PCOS). DESIGN: Prospective cohort study. SETTING: University center. PATIENT(S): One hundred sixty-three women with PCOS. INTERVENTION(S): The Beck Depression Inventory Fast Screen (BDI-FS) was self-administered at baseline and follow-up to identify depression risk, using a cutoff score >4...
November 17, 2018: Fertility and Sterility
Tim Sanchez, Tianren Wang, Marta Venturas Pedro, Man Zhang, Ecem Esencan, Denny Sakkas, Dan Needleman, Emre Seli
OBJECTIVE: To determine whether metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) identifies metabolic differences between normal oocytes and those with metabolic dysfunction. DESIGN: Experimental study. SETTING: Academic research laboratories. PATIENT(S): None. INTERVENTION(S): Oocytes from mice with global knockout of Clpp (caseinolytic peptidase P; n = 52) were compared with wild-type (WT) oocytes (n = 55) as a model of severe oocyte dysfunction...
November 13, 2018: Fertility and Sterility
Ami R Zota, Ruth J Geller, Antonia M Calafat, Cherie Q Marfori, Andrea A Baccarelli, Gaby N Moawad
OBJECTIVES: To examine the association between phthalate exposure and two measures of uterine fibroid burden: diameter of largest fibroid and uterine volume. DESIGN: Pilot, cross-sectional study. SETTING: Academic medical center. PATIENT(S): Fifty-seven premenopausal women undergoing either hysterectomy or myomectomy for fibroids. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The diameter of the largest fibroid and uterine dimensions were abstracted from medical records...
November 12, 2018: Fertility and Sterility
Jigal Haas, Jim Meriano, Rawad Bassil, Eran Barzilay, Eran Zilberberg, Robert F Casper
OBJECTIVE: To describe and compare the ongoing pregnancy rate between morulae and cavitating morulae (CAVM) transferred on day 5, to describe and compare the blastulation rate between day 5 morulae and CAVM, and to describe the pregnancy rate of these slow-developing blastocysts during a frozen embryo transfer (FET) cycle. DESIGN: Retrospective cohort study. SETTING: Single tertiary care medical center. PATIENT(S): Delayed-development embryos: 3,321 cycles that included 10,304 embryos on day 5 that were cultured until day 6...
November 12, 2018: Fertility and Sterility
Temeka Zore, Lindsay L Kroener, Chunmin Wang, Lian Liu, Richard Buyalos, Gary Hubert, Mousa Shamonki
OBJECTIVE: To evaluate the impact of segmental mosaicism on pregnancy outcomes from the transfer of embryos previously designated as euploid. DESIGN: Retrospective cohort analysis. SETTING: Single, private, high-volume fertility center. PATIENT(S): Three hundred and twenty-seven women who underwent 377 frozen single euploid embryo transfers. INTERVENTION(S): Trophectoderm biopsy of embryos cultured to the blastocyst stage, where all transferred embryos were designated euploid by high-density oligonucleotide array comparative genomic hybridization (aCGH); after ascertaining all outcomes, revaluation of aCGH results for evidence of segmental mosaicism (defined as mosaicism on a portion of a chromosome)...
November 10, 2018: Fertility and Sterility
Andria G Besser, David H McCulloh, James A Grifo
OBJECTIVE: To assess patient decisions regarding mosaic embryos and their impact on clinical outcomes. DESIGN: Review of patients who had genetic counseling regarding mosaic embryos. SETTING: Academic department. PATIENT(S): Ninety-eight patients who had mosaic embryos but no euploid embryos. INTERVENTION(S): Genetic counseling to discuss mosaic-embryo transfer (MET) after preimplantation genetic testing for aneuploidy...
November 10, 2018: Fertility and Sterility
Thomas B Pool
No abstract text is available yet for this article.
November 10, 2018: Fertility and Sterility
Ashok Agarwal, Manesh Kumar Panner Selvam, Rakesh Sharma, Kruyanshi Master, Aditi Sharma, Sajal Gupta, Ralf Henkel
OBJECTIVE: To test the ability of the smartphone-based YO Home Sperm Test to accurately and precisely measure motile sperm concentration (MSC) versus the SQA-Vision, an automated laboratory semen analyzer. DESIGN: MSC compared for the YO device on Galaxy and iPhone smartphones versus the SQA-Vision in a double-blind manner. SETTING: Academic medical center. PATIENT(S): Donor semen samples from 24 men in 144 aliquots...
November 10, 2018: Fertility and Sterility
Luís F Sávio, Robert J Carrasquillo, Justin M Dubin, Hemendra Shah, Ranjith Ramasamy
OBJECTIVE: To demonstrate a safe and effective approach to the treatment of obstructing midline prostate utricle cyst with the use of a holmium laser. DESIGN: Video presentation. SETTING: University hospital. PATIENT(S): A 33-year-old man presented with chronic pelvic pain, pain with ejaculation, and infertility. Semen analysis demonstrated oligoasthenospermia with poor viability and computerized tomographic scan identified the presence of a midline 2-3-cm prostatic cyst with dilated seminal vesicles bilaterally...
December 2018: Fertility and Sterility
Ari P Sanders, Barry Sanders
OBJECTIVE: To introduce and demonstrate an approach to the hysteroscopic removal of retained intrauterine devices (IUDs) in pregnancy. Pregnancy risks associated with retained IUDs are also discussed, specifically spontaneous abortion and preterm labor. DESIGN: A step-by-step explanation of the procedure with surgical video footage. SETTING: Academic medical center. PATIENT(S): We present four patients undergoing hysteroscopic removal of IUDs in pregnancy...
December 2018: Fertility and Sterility
Minnie Malik, Joy Britten, Mostafa Borahay, James Segars, William H Catherino
OBJECTIVE: To observe the antifibroid effects of therapeutic concentrations of simvastatin, which interferes with cholesterol biosynthesis, a known precursor of five major classes of steroid hormones, including progesterone and estrogen, which play a major role in the development and growth of uterine leiomyomas. DESIGN: Two-dimensional and three-dimensional cell culture study of immortalized human leiomyoma and patient-matched myometrium cells treated with simvastatin...
December 2018: Fertility and Sterility
Samira Behboudi-Gandevani, Fahimeh Ramezani Tehrani, Farhad Hosseinpanah, Davood Khalili, Leila Cheraghi, Hadigheh Kazemijaliseh, Fereidoun Azizi
OBJECTIVE: To evaluate the incidence of hypertension, metabolic syndrome, dyslipidemia, and obesity in comparing women with polycystic ovary syndrome (PCOS) and a control group of healthy women. DESIGN: Prospective cohort study with the median and interquartile range of 12.9 (10.8-13.9) years. SETTING: Population-based cohort of the Tehran Lipid and Glucose Study. PATIENT(S): A total of 1,702 reproductive-age women including 178 women with PCOS and 1,524 controls...
December 2018: Fertility and Sterility
Samantha C Fisch, Ariella Farzan Nikou, Elizabeth A Wright, Julia D Phan, Karen L Leung, Tristan R Grogan, David H Abbott, Gregorio D Chazenbalk, Daniel A Dumesic
OBJECTIVE: To examine whether abnormal subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes in polycystic ovary syndrome (PCOS) correlates with hyperandrogenism. DESIGN: Prospective cohort study. SETTING: Academic medical center. PATIENT(S): Eight normal-weight women with PCOS and eight normoandrogenic ovulatory (control) women matched for age and body mass index. INTERVENTION(S): Circulating hormone and metabolic measurements, intravenous glucose tolerance testing, total body dual-energy X-ray absorptiometry, and SC abdominal fat biopsy...
December 2018: Fertility and Sterility
Vincenza Barbato, Roberto Gualtieri, Teresa Capriglione, Maria Michela Pallotta, Sabrina Braun, Maddalena Di Nardo, Valentina Costanzo, Raffaele Ferraro, Gerardo Catapano, Riccardo Talevi
OBJECTIVE: To study whether slush nitrogen (SN) vs. liquid nitrogen (LN) vitrification affects human ovarian tissue gene expression and preserves follicle health during extended in vitro culture. DESIGN: Randomized experimental study. SETTING: University research laboratory. PATIENT(S): Ovarian biopsies collected by laparoscopic surgery from patients with benign gynaecologic conditions. INTERVENTION(S): None...
December 2018: Fertility and Sterility
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