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Fertility and Sterility

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https://www.readbyqxmd.com/read/29428315/association-of-testosterone-and-antim%C3%A3-llerian-hormone-with-time-to-pregnancy-and-pregnancy-loss-in-fecund-women-attempting-pregnancy
#1
Lindsey A Sjaarda, Sunni L Mumford, Daniel L Kuhr, Tiffany L Holland, Robert M Silver, Torie C Plowden, Neil J Perkins, Enrique F Schisterman
OBJECTIVE: To examine whether higher T and/or antimüllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome. DESIGN: Prospective cohort study conducted as a secondary analysis from the Effects of Aspirin in Gestation and Reproduction randomized trial. SETTING: University medical centers. PATIENT(S): A total of 1,198 healthy, eumenorrheic women aged 18-40 years attempting spontaneous pregnancy with one to two prior pregnancy losses were included...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428314/gestational-carrier-in-assisted-reproductive-technology
#2
Gayathree Murugappan, Leslie V Farland, Stacey A Missmer, Katharine F Correia, Raymond M Anchan, Elizabeth S Ginsburg
OBJECTIVE: To compare clinical outcomes of in vitro fertilization (IVF) cycles with the use of gestational carriers (GCs) with non-GC IVF cycles. DESIGN: Retrospective cohort study of assisted reproductive technology (ART) cycles performed with (24,269) and without (1,313,452) the use of a GC. SETTING: ART centers. PATIENT(S): Infertile patients seeking IVF with or without use of a GC. INTERVENTIONS(S): Autologous and donor oocyte cycles, fresh and cryopreserved embryo transfer cycles...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428313/clinical-outcomes-in-carriers-of-complex-chromosomal-rearrangements-a-retrospective-analysis-of-comprehensive-chromosome-screening-results-in-seven-cases
#3
Liang Hu, Yajing Wei, Keli Luo, Pingyuan Xie, Fei Gong, Bo Xiong, Yueqiu Tan, Guangxiu Lu, Ge Lin
OBJECTIVE: To evaluate the clinical outcomes in carriers of complex chromosomal rearrangements (CCRs). DESIGN: Case series. SETTING: An institute for reproductive and stem cell engineering. PATIENT(S): Seven couples with CCRs. INTERVENTION(S): Assisted reproduction with preimplantation genetic diagnosis (PGD). MAIN OUTCOME MEASURE(S): PGD results, embryo rating, pregnancy outcomes...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428312/reproductive-and-metabolic-determinants-of-granulosa-cell-dysfunction-in-normal-weight-women-with-polycystic-ovary-syndrome
#4
Annie A Guedikian, Alexandria Y Lee, Tristan R Grogan, David H Abbott, Karla Largaespada, Gregorio D Chazenbalk, Daniel A Dumesic
OBJECTIVE: To determine the degree to which E2 hyperresponsiveness to FSH and antimüllerian hormone (AMH) overproduction in normal-weight women with polycystic ovary syndrome (PCOS) correlate with increased antral follicle number (AFN), hyperandrogenism, and/or metabolic dysfunction. DESIGN: Prospective cohort study. SETTING: Academic medical center. PATIENT(S): Seven normal-weight women with PCOS (1990 National Institutes of Health criteria) ages 20-34 years and 13 age- and body mass index- (BMI-; 18...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428311/impact-of-cancer-treatment-on-risk-of-infertility-and-diminished-ovarian-reserve-in-women-with-polycystic-ovary-syndrome
#5
Lisa M Shandley, Amy Fothergill, Jessica B Spencer, Ann C Mertens, Hanh N Cottrell, Penelope P Howards
OBJECTIVE: To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS). DESIGN: Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women's Study-a population-based cohort study. SETTING: Not applicable. PATIENT(S): Female cancer survivors (n = 1,090) aged 22-45 years, diagnosed between ages 20 and 35 years, and at least 2 years after diagnosis; 369 participated in a clinic visit...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428310/assessing-access-to-assisted-reproductive-services-for-serodiscordant-couples-with-human-immunodeficiency-virus-infection
#6
Ashley A Leech, Pietro Bortoletto, Cindy Christiansen, Mari-Lynn Drainoni, Benjamin P Linas, Cassandra Roeca, Megan Curtis, Meg Sullivan
OBJECTIVE: To understand the barriers that serodiscordant couples with human immunodeficiency virus (HIV) face in accessing services for risk reduction and infertility using assisted reproductive technology (ART). DESIGN: Two-arm cross-sectional telephone "secret shopper" study. SETTING: Infertility clinics designated by the Society for Assisted Reproductive Technology (SART), 140 from 15 American states with the highest prevalence of heterosexual HIV-infected men...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428309/mycoplasma-genitalium-can-modulate-the-local-immune-response-in-patients-with-endometriosis
#7
Guilherme B Campos, Lucas M Marques, Izadora S Rezende, Maysa S Barbosa, Mauricio S Abrão, Jorge Timenetsky
OBJECTIVE: To detect Mollicutes in women with endometriosis and healthy peritoneal tissues and evaluate the participation of these bacteria in the immune response during endometriosis. DESIGN: Cross-sectional study. SETTING: University hospitals. PATIENT (S): Women with endometriosis (n = 73) and without endometriosis (n = 31). INTERVENTION(S): Endocervical swabs, peritoneal fluid, and biopsied lesions of endometriosis of women with endometriosis (study group) and healthy peritoneal tissues (control group) were collected during surgery...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428308/differential-rate-in-decline-in-ovarian-reserve-markers-in-women-with-polycystic-ovary-syndrome-compared-with-control-subjects-results-of-a-longitudinal-study
#8
Asima K Ahmad, Chia-Ning Kao, Molly Quinn, Nikolaus Lenhart, Mitchell Rosen, Marcelle I Cedars, Heather Huddleston
OBJECTIVE: To estimate rates of ovarian aging in polycystic ovary syndrome (PCOS) subjects versus a community control population. DESIGN: Longitudinal. SETTING: Tertiary academic center. SUBJECT(S): PCOS subjects diagnosed according to the 2004 Rotterdam criteria were systematically enrolled in a PCOS cohort study. The comparison control subjects were from the Ovarian Aging study, a prospective longitudinal study of ovarian aging in healthy women with regular menstrual cycles...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428307/oocyte-vitrification-versus-ovarian-cortex-transplantation-in-fertility-preservation-for-adult-women-undergoing-gonadotoxic-treatments-a-prospective-cohort-study
#9
Cesar Diaz-Garcia, Javier Domingo, Juan Antonio Garcia-Velasco, Sonia Herraiz, Vicente Mirabet, Ignacio Iniesta, Ana Cobo, José Remohí, Antonio Pellicer
OBJECTIVE: To compare the efficacy of oocyte vitrification (OV) with that of ovarian cortex cryopreservation and transplantation (OCT) in women undergoing gonadotoxic treatments. DESIGN: Prospective observational cohort study. SETTING: Not applicable. PATIENT(S): Candidates for chemo-/radiotherapy who joined our fertility preservation (FP) program were included in this study between 2005 and 2015. One cohort included 1,024 patients undergoing OV; the other cohort included 800 patients undergoing OCT...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428306/cumulus-cell-transcriptome-profiling-is-not-predictive-of-live-birth-after-in%C3%A2-vitro-fertilization-a-paired-analysis-of-euploid-sibling-blastocysts
#10
Katherine A Green, Jason M Franasiak, Marie D Werner, Xin Tao, Jessica N Landis, Richard T Scott, Nathan R Treff
OBJECTIVE: To compare the transcriptome of cumulus cells associated with a euploid embryo that resulted in live birth with that of a sibling euploid embryo without sustained implantation. DESIGN: Paired analysis. SETTING: Academic institution. PATIENT(S): Couples undergoing IVF/intracytoplasmic sperm injection with preimplantation genetic screening with female age ≤42 years and normal ovarian reserve. INTERVENTION(S): Transcriptome profiling of cumulus cells from sibling oocytes for correlation with live birth after euploid blastocyst transfer...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29428305/high-molecular-weight-adiponectin-is-inversely-associated-with-sympathetic-activity-in-polycystic-ovary-syndrome
#11
Soulmaz Shorakae, Sally K Abell, Danielle S Hiam, Elisabeth A Lambert, Nina Eikelis, Eveline Jona, Carolina Ika Sari, Nigel K Stepto, Gavin W Lambert, Barbora de Courten, Helena J Teede
OBJECTIVE: To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS). DESIGN: Cross sectional study using biobanked samples. SETTING: Not applicable. PATIENT(S): Premenopausal women with PCOS (n = 46, Rotterdam diagnostic criteria) and without PCOS (n = 22). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): High-molecular-weight adiponectin levels with secondary outcomes of sympathetic activity and leptin levels...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29397924/dehydroepiandrosterone-enhances-decidualization-in-women-of-advanced-reproductive-age
#12
Douglas A Gibson, Ioannis Simitsidellis, Olympia Kelepouri, Hilary O D Critchley, Philippa T K Saunders
OBJECTIVE: To investigate the impact of the androgen precursor dehydroepiandrosterone (DHEA) on the decidualization of human endometrial stromal cells isolated from women of advanced reproductive age. DESIGN: In vitro study. SETTING: University research institute. PATIENT(S): Proliferative phase primary human endometrial stromal fibroblasts (hESFs) were isolated from women of advanced reproductive age (n = 16; mean age, 44...
February 1, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29395096/exome-and-genome-sequencing-in-reproductive-medicine
#13
REVIEW
Elizabeth A Normand, Joseph T Alaimo, Ignatia B Van den Veyver
The advent of next-generation sequencing has enabled clinicians to assess many genes simultaneously and at high resolution. This is advantageous for diagnosing patients in whom a genetic disorder is suspected but who have a nonspecific or atypical phenotype or when the disorder has significant genetic heterogeneity. Herein, we describe common clinical applications of next-generation sequencing technology, as well as their respective benefits and limitations. We then discuss key considerations of variant interpretation and reporting, clinical utility, pre- and posttest genetic counseling, and ethical challenges...
January 27, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29395095/nature-versus-science-transferring-embryos-or-blame
#14
EDITORIAL
Neil Ryan Chappell, William E Gibbons
No abstract text is available yet for this article.
January 27, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29395094/robotic-assisted-surgery-in-live-donor-uterus-transplantation
#15
EDITORIAL
Mats Brännström, Pernilla Dahm-Kähler, Niclas Kvarnström
No abstract text is available yet for this article.
January 27, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338857/obstetric-complications-after-frozen-versus-fresh-embryo-transfer-in-women-with-polycystic-ovary-syndrome-results-from-a-randomized-trial
#16
Bo Zhang, Daimin Wei, Richard S Legro, Yuhua Shi, Jing Li, Lin Zhang, Yan Hong, Gang Sun, Ting Zhang, Weiping Li, Zi-Jiang Chen
OBJECTIVE: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS). DESIGN: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). SETTING: Reproductive medicine centers. PATIENT(S): A total of 1,508 patients with a diagnosis of PCOS who were undergoing IVF were enrolled...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338856/parental-health-status-and-infant-outcomes-upstate-kids-study
#17
Germaine M Buck Louis, Erin Bell, Yunlong Xie, Rajeshwari Sundaram, Edwina Yeung
OBJECTIVE: To assess parental health status inclusive of infertility and infant outcomes. DESIGN: Birth cohort with cross-sectional analysis of parental health status and infant outcomes. SETTING: Not applicable. PATIENT(S): Parents (n = 4,886) and infants (n = 5,845) participating in the Upstate KIDS birth cohort. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Infertility was defined as [1] sexually active without contraception for 1+ years without pregnancy, [2] ever requiring ≥12 months to become pregnant, and [3] requiring ≥12 months for index pregnancy...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338855/vitrified-blastocyst-transfer-cycles-with-the-use-of-only-vaginal-progesterone-replacement-with-endometrin-have-inferior-ongoing-pregnancy-rates-results-from-the-planned-interim-analysis-of-a-three-arm-randomized-controlled-noninferiority-trial
#18
Kate Devine, Kevin S Richter, Eric A Widra, Jeffrey L McKeeby
OBJECTIVE: To assess the noninferiority of vaginal P (Endometrin) compared with daily intramuscular P for replacement in programmed vitrified-warmed blastocyst transfer cycles and to assess the noninferiority of vaginal P in combination with intramuscular progesterone every third day compared with daily intramuscular P. DESIGN: Three-arm randomized controlled noninferiority study. To enable early recognition of inferiority if present, an a priori interim analysis was planned and completed once ongoing pregnancy data were available for 50% of the total enrollment goal...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338854/long-term-outcomes-in-cancer-patients-who-did-or-did-not-pursue-fertility-preservation
#19
Molly B Moravek, Rafael Confino, Kristin N Smith, Ralph R Kazer, Susan C Klock, Angela K Lawson, William J Gradishar, Mary Ellen Pavone
OBJECTIVE: To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle-specific (CS) protocols for FP. DESIGN: Retrospective cohort. SETTING: Single urban academic institution. PATIENT(S): Oncology patients who contacted the FP patient navigator, 2005-2015. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Time to cancer treatment, disease-free survival, and reproductive outcomes in FP versus no-FP patients and cycle outcomes for RS versus CS protocols...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29331240/a-new-predictive-parameter-for-embryo-transfer-success-but-a-path-forward-is-needed-to-implement-it-in-technique-training-path-forward-needed-to-implement-in-technique-training
#20
EDITORIAL
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