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Fertility and Sterility

Kelly Acharya, Suheil Muasher
No abstract text is available yet for this article.
July 23, 2018: Fertility and Sterility
Michelle M Denomme, Blair R McCallie, Jason C Parks, Keith Booher, William B Schoolcraft, Mandy G Katz-Jaffe
OBJECTIVE: To evaluate the epigenetic consequence on the methylome and subsequent transcriptome in euploid blastocysts of male-factor (MF) infertility patients. DESIGN: Methylome and transcriptome analysis on individual oligoasthenoteratozoospermia (OAT [MF]) blastocysts. SETTING: Infertility clinic. PATIENT(S): Clinical data from 128 couples presenting with OAT (MF) and 118 maternal age-matched control (no MF) subjects undergoing infertility treatment from 2010 to 2014, along with 72 surplus cryopreserved blastocysts donated from 33 couples with their informed consents...
June 28, 2018: Fertility and Sterility
Valerie L Baker, Clarisa Gracia, Michael J Glassner, Vicki L Schnell, Kevin Doody, Charles C Coddington, Sanghyuk S Shin, Lorna A Marshall, Michael M Alper, Arlene J Morales, Mary Ellen Pavone, Millie A Behera, Edward A Zbella, Bruce S Shapiro, Joely A Straseski, Dennis L Broyles
OBJECTIVE: To evaluate a new fully automated antimüllerian hormone (AMH) assay for prediction of poor ovarian response (POR) to ovarian stimulation defined as four or fewer oocytes retrieved. DESIGN: Prospective cohort study. SETTING: Thirteen private and academic fertility centers in the United States. PATIENTS(S): A total of 178 women undergoing their first in vitro fertilization (IVF) cycle eligible for the study were consented and enrolled, with data available from 160 women for prediction of POR and 164 women for AMH correlation with antral follicle count (AFC)...
June 27, 2018: Fertility and Sterility
Jacqueline R Ho, Nabil Arrach, Katherine Rhodes-Long, Ali Ahmady, Sue Ingles, Karine Chung, Kristin A Bendikson, Richard J Paulson, Lynda K McGinnis
OBJECTIVE: To determine the accuracy of cell-free DNA (cfDNA) in spent embryo medium (SEM) for ploidy and sex detection at the cleavage and blastocyst stages. To determine if assisted hatching (AH) and morphologic grade influence cfDNA concentration and accuracy. DESIGN: Prospective cohort. SETTING: Academic fertility center. PATIENT(S): Nine patients undergoing IVF; 41 donated two-pronuclei embryos and 20 embryos from patients undergoing preimplantation genetic testing for aneuploidy (PGT-A)...
June 27, 2018: Fertility and Sterility
Nadia N Khan, Amanda Vincent, Jacqueline A Boyle, Millicent Burggraf, Monisha Pillay, Helena Teede, Melanie Gibson-Helm
OBJECTIVE: To develop a question prompt list (QPL) for women with polycystic ovary syndrome (PCOS) and explore its acceptability and feasibility. DESIGN: Nationwide online survey, interviews, and clinical pilot test. SETTING: Australia. PATIENT(S): Two-hundred and forty-nine women online, 18 women in interviews, and 20 women in clinics. INTERVENTION(S): A QPL for PCOS. MAIN OUTCOME MEASURE(S): From survey, women's likeliness to use a QPL and priority topics; from interview, QPL user-friendliness and associated feelings; from pilot, women's QPL use, perceived helpfulness, and intended future use...
June 27, 2018: Fertility and Sterility
Paula C Brady, Elizabeth S Ginsburg
No abstract text is available yet for this article.
June 27, 2018: Fertility and Sterility
Kotaro Kitaya, Takumi Takeuchi, Shimpei Mizuta, Hidehiko Matsubayashi, Tomomoto Ishikawa
Endometritis is subdivided into two categories. Acute endometritis is symptomatic and characterized by microabscess formation and neutrophil invasion in the endometrial superficial epithelium, gland lumina, and uterine cavity. Chronic endometritis is rather silent and recognized as unusual plasmacyte infiltration in the endometrial stromal areas. Over the last decade, studies have disclosed the potential association between poor reproductive outcomes and endometritis, particularly chronic endometritis. The aim of this review is to address the current literature surrounding chronic endometritis and highlight recent advances in the research of this long-neglected gynecologic disease...
June 27, 2018: Fertility and Sterility
Bulent Yilmaz, Priyathama Vellanki, Baris Ata, Bulent Okan Yildiz
OBJECTIVE(S): To analyze whether first-degree relatives (FDR) of patients with polysystic ovary syndrome (PCOS) have an increased risk of insulin resistance and glucose intolerance. DESIGN: Systematic review and meta-analysis. SETTING: None. PATIENT(S): Parents and siblings of women with and without PCOS. INTERVENTION(S): Search of PubMed database from 1960 to September 2017 with cross-checking of references of relevant articles in English...
June 27, 2018: Fertility and Sterility
Luciana Cacciottola, Diego Daniel Manavella, Christiani Andrade Amorim, Jacques Donnez, Marie-Madeleine Dolmans
OBJECTIVE: To characterize oxidative stress and metabolic activity in xenografted human ovarian tissue using microdialysis. DESIGN: Prospective experimental study. SETTING: Gynecology research unit at a university hospital. PATIENT(S): Cryopreserved ovarian cortex from five women 27-35 years of age. INTERVENTION(S): Frozen-thawed human ovarian tissue fragments were xenografted to the back muscle of ten nude mice...
June 27, 2018: Fertility and Sterility
Sonia Herraiz, Mónica Romeu, Anna Buigues, Susana Martínez, César Díaz-García, Inés Gómez-Seguí, José Martínez, Nuria Pellicer, Antonio Pellicer
OBJECTIVE: To evaluate effects of autologous stem cell ovarian transplant (ASCOT) on ovarian reserve and IVF outcomes of women who are poor responders with very poor prognosis. DESIGN: Prospective observational pilot study. SETTING: University hospital. PATIENT(S): Seventeen women who are poor responders. INTERVENTION(S): Ovarian infusion of bone marrow-derived stem cells. MAIN OUTCOME MEASURE(S): Serum antimüllerian hormone levels and antral follicular count (AFC), punctured follicles, and oocytes retrieved after stimulation (controlled ovarian stimulation) were measred...
June 27, 2018: Fertility and Sterility
Ari P Sanders, Ally Murji
OBJECTIVE: To demonstrate an approach to the hysteroscopic repair of cesarean scar isthmocele and discuss its association with secondary infertility. DESIGN: A step-by-step explanation of the procedure with surgical video footage. SETTING: Academic medical center. PATIENT(S): Two patients undergoing hysteroscopic repair of symptomatic cesarean scar isthmoceles. Surgical candidates for this procedure include patients with a symptomatic isthmocele and a residual myometrial thickness of at least 3 mm confirmed with pre-operative imaging...
August 2018: Fertility and Sterility
Ping-Yuan Xie, Yi Tang, Liang Hu, Qi Ouyang, Yi-Fan Gu, Fei Gong, Li-Zhi Leng, Shuo-Ping Zhang, Bo Xiong, Guang-Xiu Lu, Ge Lin
OBJECTIVE: To select normal fertilized diploid blastocysts in patients who had only monopronucleated (1PN) embryos for transfer. DESIGN: Experimental study. SETTING: University-affiliated center. PATIENT(S): Couples who were undergoing intracytoplasmic sperm injection treatment and had 1PN blastocysts. INTERVENTION(S): In a preliminary test, limited cells of parthenogenetic human embryonic stem cells (phESCs) and normal fertilized blastocysts were analyzed with the use of a low-density single-nucleotide polymorphism (SNP) array to identify the distribution pattern and rate of heterozygosity...
August 2018: Fertility and Sterility
Chengming Zhou, Yonghua Niu, Hao Xu, Zongzhe Li, Tao Wang, Weimin Yang, Shaogang Wang, Dao Wen Wang, Jihong Liu
OBJECTIVE: To investigate the mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism (IHH) and discover new pathogenic genes that cause IHH. DESIGN: A gene panel, including 31 known IHH genes and 52 candidate genes, was used to perform semiconductor next-generation sequencing. SETTING: University hospital. PATIENTS: One hundred thirty-eight sporadic male IHH patients and 10 IHH families; 100 healthy men with normal fertility served as control subjects...
August 2018: Fertility and Sterility
Cristiana L Miranda-Furtado, Heloise R Luchiari, Daiana C Chielli Pedroso, Gislaine S Kogure, Lisandra C Caetano, Bárbara A Santana, Viviane P Santana, Cristina L Benetti-Pinto, Fernando M Reis, Mariella A Maciel, Rui A Ferriani, Ester S Ramos, Rodrigo T Calado, Rosana M Dos Reis
OBJECTIVE: To analyze whether telomere length, X-chromosome inactivation (XCI), and androgen receptor (AR) GAG polymorphism are related to idiopathic premature ovarian insufficiency (POI). DESIGN: Case-control study. SETTING: University hospital. PATIENT(S): A total of 121 women, including 46 nonsyndromic POI and 75 controls. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Age, weight, height, body mass index (BMI), systolic and diastolic arterial pressure, E2 , androstenedione, T, and C-reactive protein were assessed...
August 2018: Fertility and Sterility
Konstantinos Nirgianakis, Maria Luisa Gasparri, Anda-Petronela Radan, Anna Villiger, Brett McKinnon, Beatrice Mosimann, Andrea Papadia, Michael D Mueller
OBJECTIVE: To study obstetric outcomes and complications in women with previously excised posterior deep infiltrating endometriosis (DIE) in comparison with women without endometriosis. DESIGN: Matched case-control study. SETTING: Tertiary-level academic center. PATIENT(S): All surgeries for endometriosis performed in the Department of Gynecology and Gynecological Oncology, University of Bern between March 2004 and July 2015, were assessed...
August 2018: Fertility and Sterility
Shirley Cueva, Channing Burks, Dana McQueen, Marla S Barkoff, Mary D Stephenson
OBJECTIVE: To determine whether an association exists between maternal antithyroid antibodies and euploid miscarriage in women with recurrent early pregnancy loss (REPL). DESIGN: Observational cohort study. SETTING: Two academic medical centers. PATIENT(S): Women seen between 2004-2015 with a history of REPL, who were euthyroid or had subclinical hypothyroidism, had maternal antithyroid antibody testing and had at least one subsequent early pregnancy loss (<10 weeks' gestation)...
August 2018: Fertility and Sterility
Atsushi Tanaka, Kohta Suzuki, Motoi Nagayoshi, Akihiro Tanaka, Youichi Takemoto, Seiji Watanabe, Satoru Takeda, Minoru Irahara, Naoaki Kuji, Zentaro Yamagata, Ryuzo Yanagimachi
OBJECTIVE: To compare physical and cognitive development of babies born after round spermatid injection (ROSI) with those born after natural conception. DESIGN: Comparison of efficiencies of ROSI and ICSI using testicular spermatozoa, performed in the St. Mother Clinic. Physical and cognitive development of ROSI babies recorded by parents in the government-issued Mother-Child Handbook was checked and verified by attending pediatricians. Data included baby's weight gain and response to parents' voice/gesture...
August 2018: Fertility and Sterility
Caroline R Juneau, Jason M Franasiak, Linnea R Goodman, Diego Marin, Katherine Scott, Scott J Morin, Shelby A Neal, Jeffrey E Juneau, Richard T Scott
OBJECTIVE: To study the prevalence of celiac disease in the infertile population undergoing in vitro fertilization (IVF) and assess outcomes. DESIGN: Prospective cohort study. SETTING: A single infertility center from January 2016 to March 2017. PATIENT(S): Women 18-45 years of age participating in IVF. INTERVENTION(S): Patients had serum tissue transglutaminase (tTG) and endomysial (EMA) IgA testing to screen for celiac disease and completed a 10-question "yes or no" survey to assess their medical history, previous testing, dietary habits, and pertinent symptoms...
August 2018: Fertility and Sterility
Judy E Stern, Chia-Ling Liu, Howard J Cabral, Elliott G Richards, Charles C Coddington, Stacey A Missmer, Hafsatou Diop
OBJECTIVE: To quantify the effect of medical and obstetrical factors on the odds of cesarean delivery, comparing assisted reproductive technology (ART)-treated women and women with subfertility not treated with ART versus fertile women. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Singleton deliveries to primiparous women; with the source of this data being the Massachusetts vital and hospital records linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System data (2004-2010)...
August 2018: Fertility and Sterility
Bala Bhagavath, Steven R Lindheim
No abstract text is available yet for this article.
August 2018: Fertility and Sterility
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