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European Urology

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https://www.readbyqxmd.com/read/28336080/re-mid-term-outcomes-after-advancexp-male-sling-implantation
#1
Emilio Rios, Luis Martinez-Piñeiro
No abstract text is available yet for this article.
March 20, 2017: European Urology
https://www.readbyqxmd.com/read/28336079/re-radiation-with-or-without-antiandrogen-therapy-in-recurrent-prostate-cancer
#2
Benjamin W Lamb, John Violet, Shankar Siva, Declan G Murphy
No abstract text is available yet for this article.
March 20, 2017: European Urology
https://www.readbyqxmd.com/read/28336078/what-is-the-negative-predictive-value-of-multiparametric-magnetic-resonance-imaging-in-excluding-prostate-cancer-at-biopsy-a-systematic-review-and-meta-analysis-from-the-european-association-of-urology-prostate-cancer-guidelines-panel
#3
REVIEW
Paul C Moldovan, Thomas Van den Broeck, Richard Sylvester, Lorenzo Marconi, Joaquim Bellmunt, Roderick C N van den Bergh, Michel Bolla, Erik Briers, Marcus G Cumberbatch, Nicola Fossati, Tobias Gross, Ann M Henry, Steven Joniau, Theo H van der Kwast, Vsevolod B Matveev, Henk G van der Poel, Maria De Santis, Ivo G Schoots, Thomas Wiegel, Cathy Yuhong Yuan, Philip Cornford, Nicolas Mottet, Thomas B Lam, Olivier Rouvière
CONTEXT: It remains unclear whether patients with a suspicion of prostate cancer (PCa) and negative multiparametric magnetic resonance imaging (mpMRI) can safely obviate prostate biopsy. OBJECTIVE: To systematically review the literature assessing the negative predictive value (NPV) of mpMRI in patients with a suspicion of PCa. EVIDENCE ACQUISITION: The Embase, Medline, and Cochrane databases were searched up to February 2016. Studies reporting prebiopsy mpMRI results using transrectal or transperineal biopsy as a reference standard were included...
March 20, 2017: European Urology
https://www.readbyqxmd.com/read/28330676/stromal-gene-expression-is-predictive-for-metastatic-primary-prostate-cancer
#4
Fan Mo, Dong Lin, Mandeep Takhar, Varune Rohan Ramnarine, Xin Dong, Robert H Bell, Stanislav V Volik, Kendric Wang, Hui Xue, Yuwei Wang, Anne Haegert, Shawn Anderson, Sonal Brahmbhatt, Nicholas Erho, Xinya Wang, Peter W Gout, James Morris, R Jeffrey Karnes, Robert B Den, Eric A Klein, Edward M Schaeffer, Ashley Ross, Shancheng Ren, S Cenk Sahinalp, Yingrui Li, Xun Xu, Jun Wang, Jian Wang, Martin E Gleave, Elai Davicioni, Yinghao Sun, Yuzhuo Wang, Colin C Collins
BACKGROUND: Clinical grading systems using clinical features alongside nomograms lack precision in guiding treatment decisions in prostate cancer (PCa). There is a critical need for identification of biomarkers that can more accurately stratify patients with primary PCa. OBJECTIVE: To identify a robust prognostic signature to better distinguish indolent from aggressive prostate cancer (PCa). DESIGN, SETTING, AND PARTICIPANTS: To develop the signature, whole-genome and whole-transcriptome sequencing was conducted on five PCa patient-derived xenograft (PDX) models collected from independent foci of a single primary tumor and exhibiting variable metastatic phenotypes...
March 19, 2017: European Urology
https://www.readbyqxmd.com/read/28325537/midline-extraperitoneal-approach-to-retroperitoneal-lymph-node-dissection-in-testicular-cancer-minimizing-surgical-morbidity
#5
Sumeet Syan-Bhanvadia, Soroush T Bazargani, Thomas G Clifford, Jie Cai, Gus Miranda, Siamak Daneshmand
BACKGROUND: Retroperitoneal lymph node dissection (RPLND) is an important component of the management of testicular germ cell tumor (GCT) but carries significant surgical morbidity. OBJECTIVE: To describe our experience with a midline extraperitoneal (EP) approach to RPLND for seminomatous and nonseminomatous GCT. DESIGN, SETTING, AND PARTICIPANTS: From 2010 to 2015, 122 consecutive patients underwent RPLND from a prospective database. Patients requiring aortic resection or retrocrural dissection or with intraperitoneal disease were excluded...
March 18, 2017: European Urology
https://www.readbyqxmd.com/read/28318727/re-giorgio-gandaglia-alberto-briganti-noel-clarke-et-al-adjuvant-and-salvage-radiotherapy-after-radical-prostatectomy-in-prostate-cancer-patients-eur-urol-in-press-http-dx-doi-org-10-1016-j-eururo-2017-01-039
#6
LETTER
Filippo Alongi, Dario Aiello, Rosario Mazzola, Stefano Cavalleri
No abstract text is available yet for this article.
March 15, 2017: European Urology
https://www.readbyqxmd.com/read/28318726/low-risk-prostate-cancer-identification-management-and-outcomes
#7
REVIEW
Marco Moschini, Peter R Carroll, Scott E Eggener, Jonathan I Epstein, Markus Graefen, Rodolfo Montironi, Christopher Parker
CONTEXT: The incidence of low-risk prostate cancer (PCa) has increased as a consequence of prostate-specific antigen testing. OBJECTIVE: In this collaborative review article, we examine recent literature regarding low-risk PCa and the available prognostic and therapeutic options. EVIDENCE ACQUISITION: We performed a literature review of the Medline, Embase, and Web of Science databases. The search strategy included the terms: prostate cancer, low risk, active surveillance, focal therapy, radical prostatectomy, watchful waiting, biomarker, magnetic resonance imaging, alone or in combination...
March 15, 2017: European Urology
https://www.readbyqxmd.com/read/28314611/clinical-outcomes-from-androgen-signaling-directed-therapy-after-treatment-with-abiraterone-acetate-and-prednisone-in-patients-with-metastatic-castration-resistant-prostate-cancer-post-hoc-analysis-of-cou-aa-302
#8
Matthew R Smith, Fred Saad, Dana E Rathkopf, Peter F A Mulders, Johann S de Bono, Eric J Small, Neal D Shore, Karim Fizazi, Thian Kheoh, Jinhui Li, Peter De Porre, Mary B Todd, Margaret K Yu, Charles J Ryan
In the COU-AA-302 trial, abiraterone acetate plus prednisone significantly increased overall survival for patients with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC). Limited information exists regarding response to subsequent androgen signaling-directed therapies following abiraterone acetate plus prednisone in patients with mCRPC. We investigated clinical outcomes associated with subsequent abiraterone acetate plus prednisone (55 patients) and enzalutamide (33 patients) in a post hoc analysis of COU-AA-302...
March 14, 2017: European Urology
https://www.readbyqxmd.com/read/28314610/subset-analyses-from-checkmate-025-a-challenge-to-current-clinical-dogma
#9
EDITORIAL
Sumanta K Pal, Manuel C Maia, Nazli Dizman, Neeraj Agarwal
No abstract text is available yet for this article.
March 14, 2017: European Urology
https://www.readbyqxmd.com/read/28314609/germline-dna-repair-mutations-and-response-to-hormonal-therapy-in-advanced-prostate-cancer
#10
EDITORIAL
Emmanuel S Antonarakis
No abstract text is available yet for this article.
March 14, 2017: European Urology
https://www.readbyqxmd.com/read/28292549/re-kenneth-a-iczkowski-s-letter-to-the-editor-re-re-rodolfo-montironi-silvia-gasparrini-roberta-mazzucchelli-et-al-s-letter-to-the-editor-re-karim-a-touijer-james-a-eastham-the-sentinel-lymph-node-concept-and-novel-approaches-in-detecting-lymph-node-metastasis
#11
LETTER
https://www.readbyqxmd.com/read/28292548/re-elective-nephron-sparing-surgery-decreases-other-cause-mortality-relative-to-radical-nephrectomy-only-in-specific-subgroups-of-patients-with-renal-cell-carcinoma
#12
https://www.readbyqxmd.com/read/28284740/re-rodolfo-montironi-silvia-gasparrini-roberta-mazzucchelli-et-al-s-letter-to-the-editor-re-karim-a-touijer-james-a-eastham-the-sentinel-lymph-node-concept-and-novel-approaches-in-detecting-lymph-node-metastasis-in-prostate-cancer-eur-urol-2016-70-738-9-sentinel
#13
LETTER
https://www.readbyqxmd.com/read/28284739/kiurologyx-urology-as-you-like-it-a-massive-open-online-course-for-medical-students-professionals-patients-and-laypeople-alike
#14
EDITORIAL
Lars Henningsohn, Nima Dastaviz, Natalia Stathakarou, Cormac McGrath
KIUrologyX is a massive open online course in clinical urology that allows a broad range of people access to important clinical knowledge. It is a course that can be made available to an unlimited number of students, professionals, patients, and their kin.
March 8, 2017: European Urology
https://www.readbyqxmd.com/read/28284738/procedure-specific-risks-of-thrombosis-and-bleeding-in-urological-non-cancer-surgery-systematic-review-and-meta-analysis
#15
REVIEW
Kari A O Tikkinen, Samantha Craigie, Arnav Agarwal, Reed A C Siemieniuk, Rufus Cartwright, Philippe D Violette, Giacomo Novara, Richard Naspro, Chika Agbassi, Bassel Ali, Maha Imam, Nofisat Ismaila, Denise Kam, Michael K Gould, Per Morten Sandset, Gordon H Guyatt
CONTEXT: Pharmacological thromboprophylaxis involves a trade-off between a reduction in venous thromboembolism (VTE) and increased bleeding. No guidance specific for procedure and patient factors exists in urology. OBJECTIVE: To inform estimates of absolute risk of symptomatic VTE and bleeding requiring reoperation in urological non-cancer surgery. EVIDENCE ACQUISITION: We searched for contemporary observational studies and estimated the risk of symptomatic VTE or bleeding requiring reoperation in the 4 wk after urological surgery...
March 8, 2017: European Urology
https://www.readbyqxmd.com/read/28283344/-gotta-catch-em-all-or-do-we-pokemet-approach-to-metastatic-prostate-cancer
#16
EDITORIAL
Declan G Murphy, Christopher J Sweeney, Bertrand Tombal
Metastasis-directed therapy is of interest for the management of oligometastatic prostate cancer. Improved imaging may help with patient selection, but the approach to metastatic prostate cancer of "catching 'em all", or "Pokemet", must be considered experimental.
March 7, 2017: European Urology
https://www.readbyqxmd.com/read/28279514/re-j-alfred-witjes-thierry-lebret-eva-m-comp%C3%A3-rat-et-al-updated-2016-eau-guidelines-on-muscle-invasive-and-metastatic-bladder-cancer-eur-urol-2017-71-462-75
#17
LETTER
Pero Bokarica, Adelina Hrkac, Ivan Gilja
No abstract text is available yet for this article.
March 6, 2017: European Urology
https://www.readbyqxmd.com/read/28262412/minimally-invasive-laparoscopic-and-robotic-assisted-techniques-versus-open-techniques-for-kidney-transplant-recipients-a-systematic-review
#18
Sven Wagenaar, Johanna H Nederhoed, Arjan W J Hoksbergen, H Jaap Bonjer, Willem Wisselink, Gabrielle H van Ramshorst
CONTEXT: Literature on conventional and minimally invasive operative techniques has not been systematically reviewed for kidney transplant recipients. OBJECTIVE: To systematically evaluate, summarize, and review evidence supporting operating technique and postoperative outcome for kidney transplant recipients. EVIDENCE ACQUISITION: A systematic review was conducted in PubMed-Medline, Embase, and Cochrane Library between 1966 up to September 1, 2016, according to Preferred Reporting Items for Systematic Review and Meta-analysis guidelines...
March 3, 2017: European Urology
https://www.readbyqxmd.com/read/28262414/prostate-imaging-reporting-and-data-system-version-2-and-the-implementation-of-high-quality-prostate-magnetic-resonance-imaging
#19
EDITORIAL
Jelle Barentsz, Maarten de Rooij, Geert Villeirs, Jeffrey Weinreb
No abstract text is available yet for this article.
March 2, 2017: European Urology
https://www.readbyqxmd.com/read/28262413/checkmate-025-randomized-phase-3-study-outcomes-by-key-baseline-factors-and-prior-therapy-for-nivolumab-versus-everolimus-in-advanced-renal-cell-carcinoma
#20
Bernard Escudier, Padmanee Sharma, David F McDermott, Saby George, Hans J Hammers, Sandhya Srinivas, Scott S Tykodi, Jeffrey A Sosman, Giuseppe Procopio, Elizabeth R Plimack, Daniel Castellano, Howard Gurney, Frede Donskov, Katriina Peltola, John Wagstaff, Thomas C Gauler, Takeshi Ueda, Huanyu Zhao, Ian M Waxman, Robert J Motzer
BACKGROUND: The randomized, phase 3 CheckMate 025 study of nivolumab (n=410) versus everolimus (n=411) in previously treated adults (75% male; 88% white) with advanced renal cell carcinoma (aRCC) demonstrated significantly improved overall survival (OS) and objective response rate (ORR). OBJECTIVE: To investigate which baseline factors were associated with OS and ORR benefit with nivolumab versus everolimus. DESIGN, SETTING, AND PARTICIPANTS: Subgroup OS analyses were performed using Kaplan-Meier methodology...
March 2, 2017: European Urology
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