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European Urology

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https://www.readbyqxmd.com/read/28442164/if-you-want-to-make-an-important-discovery-listen-to-your-patients
#1
EDITORIAL
Patrick C Walsh
No one knows more about certain aspects of a disease than the patient who has it. So, listen to your patients and they may lead you in a direction in which no one else is going.
April 22, 2017: European Urology
https://www.readbyqxmd.com/read/28442163/the-search-for-the-missing-heritability-of-prostate-cancer
#2
EDITORIAL
Patrick C Walsh
Scientists and clinicians at Johns Hopkins have been working since 1987 to uncover the genetic pathogenesis of prostate cancer. A patient query about the hereditary nature of the disease led to data collection on family history, followed by segregation and linkage analyses. Collaborative investigations using next-generation sequencing to identify genetic variants associated with prostate cancer risk have revealed the significance of HOXB13, BRCA 1/2, and DNA repair mutations.
April 22, 2017: European Urology
https://www.readbyqxmd.com/read/28442162/morbidity-of-metastasectomy-for-renal-cell-carcinoma-emerging-evidence-and-unmet-needs
#3
EDITORIAL
Andrea Minervini, Riccardo Campi, Alberto Lapini, Marco Carini
No abstract text is available yet for this article.
April 22, 2017: European Urology
https://www.readbyqxmd.com/read/28434677/the-microbiome-of-the-prostate-tumor-microenvironment
#4
Ilaria Cavarretta, Roberto Ferrarese, Walter Cazzaniga, Diego Saita, Roberta Lucianò, Elisa R Ceresola, Irene Locatelli, Laura Visconti, Giovanni Lavorgna, Alberto Briganti, Manuela Nebuloni, Claudio Doglioni, Massimo Clementi, Francesco Montorsi, Filippo Canducci, Andrea Salonia
BACKGROUND: The advent of molecular-based methods of identification and characterization of complex microbial populations has led to a new era of microbial discovery. A detailed and comprehensive analysis of the microbial ecosystem of the pathologic and healthy prostate tissues has not been yet reported. OBJECTIVES: To characterize the microbiome possibly associated to the pathologic prostate microenvironment. DESIGN, SETTING, AND PARTICIPANTS: The microbiome profile of tumor, peri-tumor, and nontumor tissues was assessed on 16 radical prostatectomy-specimens...
April 20, 2017: European Urology
https://www.readbyqxmd.com/read/28434676/meta-analysis-of-results-of-testosterone-therapy-on-sexual-function-based-on-international-index-of-erectile-function-scores
#5
Giovanni Corona, Giulia Rastrelli, Abraham Morgentaler, Alessandra Sforza, Edoardo Mannucci, Mario Maggi
CONTEXT: The interpretation of available clinical evidence related to the effect of testosterone (T) treatment (TTh) on sexual function has been inconsistent, in part due to the use of different and self-reported measures to assess outcomes. The International Index of Erectile Function (IIEF) is the most frequently used validated tool to assess male sexual function. OBJECTIVE: To perform a meta-analysis of available data evaluating the effect of TTh on male sexual function using IIEF as the primary outcome...
April 20, 2017: European Urology
https://www.readbyqxmd.com/read/28433379/re-richard-j-sylvester-steven-e-canfield-thomas-b-l-lam-et-al-conflict-of-evidence-resolving-discrepancies-when-findings-from-randomized-controlled-trials-and-meta-analyses-disagree-eur-urol-2017-71-811-9
#6
LETTER
https://www.readbyqxmd.com/read/28433378/prostate-cancer-management-in-an-ageing-population
#7
EDITORIAL
Jeremy P Grummet, Karin Plass, James N'Dow
No abstract text is available yet for this article.
April 19, 2017: European Urology
https://www.readbyqxmd.com/read/28433377/neoadjuvant-chemotherapy-in-muscle-invasive-bladder-cancer-are-things-now-getting-personal
#8
EDITORIAL
Matthew D Galsky, John P Sfakianos, Bart S Ferket
No abstract text is available yet for this article.
April 19, 2017: European Urology
https://www.readbyqxmd.com/read/28433376/is-a-normal-testosterone-level-necessary-for-erectile-function
#9
EDITORIAL
Taylor P Kohn, Ranjith Ramasamy
No abstract text is available yet for this article.
April 19, 2017: European Urology
https://www.readbyqxmd.com/read/28427786/reply-to-philipp-dahm-vikram-narayan-and-jae-hung-jung-s-letter-to-the-editor-re-richard-j-sylvester-steven-e-canfield-thomas-b-l-lam-et-al-conflict-of-evidence-resolving-discrepancies-when-findings-from-randomized-controlled-trials-and-meta-analyses-disagree
#10
LETTER
Thomas B L Lam, Richard J Sylvester, Steven E Canfield, Lorenzo Marconi, Steven MacLennan, Yuhong Yuan, Muhammad Imran Omar, James N'Dow
No abstract text is available yet for this article.
April 17, 2017: European Urology
https://www.readbyqxmd.com/read/28427785/seeking-the-molecular-truth-in-bladder-cancer-biology-genome%C3%A3-transcriptome-2
#11
EDITORIAL
Peter C Black
No abstract text is available yet for this article.
April 17, 2017: European Urology
https://www.readbyqxmd.com/read/28416351/intraductal-carcinoma-of-the-prostate-anonymous-to-ominous
#12
EDITORIAL
Melvin L K Chua, Theodorus H van der Kwast, Robert G Bristow
No abstract text is available yet for this article.
April 14, 2017: European Urology
https://www.readbyqxmd.com/read/28416350/survival-among-men-at-high-risk-of-disseminated-prostate-cancer-receiving-initial-locally-directed-radical-treatment-or-initial-androgen-deprivation-therapy
#13
Prasanna Sooriakumaran, Tommy Nyberg, Olof Akre, Anders Widmark, Freddie Hamdy, Markus Graefen, Stefan Carlsson, Gunnar Steineck, N Peter Wiklund
BACKGROUND: There is increasing low-quality evidence rationalizing the use of radical therapy for men at high risk of disseminated prostate cancer. OBJECTIVE: To investigate, using high-quality epidemiologic data, whether initial radical therapy in men at high risk of disseminated prostate cancer improves survival. DESIGN, SETTING, AND PARTICIPANTS: An observational population-based Swedish study from 1996 to 2010 of men at high risk of disseminated prostate cancer (prostate-specific antigen [PSA] >50) initially treated by radical therapy (radiation therapy [n=630] or radical prostatectomy [n=120]) or androgen deprivation therapy (n=17 602), and followed for up to 15 yr...
April 14, 2017: European Urology
https://www.readbyqxmd.com/read/28413128/immune-checkpoint-inhibition-in-metastatic-urothelial-cancer
#14
EDITORIAL
Tom Powles, Kate Smith, Arnulf Stenzl, Jens Bedke
Immune checkpoint inhibitors are a new treatment option in metastatic urothelial cancer on the basis of available phase 2 and 3 trials. Predictive biomarkers are needed. These should go beyond PD-L1 expression, which is showing inconsistent results across trials.
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28413127/evolution-of-circulating-tumor-dna-profile-from-first-line-to-subsequent-therapy-in-metastatic-renal-cell-carcinoma
#15
Sumanta K Pal, Guru Sonpavde, Neeraj Agarwal, Nicholas J Vogelzang, Sandy Srinivas, Naomi B Haas, Sabina Signoretti, Bradley A McGregor, Jeremy Jones, Richard B Lanman, Kimberly C Banks, Toni K Choueiri
BACKGROUND: Treatment of metastatic renal cell carcinoma (mRCC) typically entails mechanistically distinct agents across the first- and second-line setting. Activity of these agents may be predicated on selective pressure that modulates RCC biology. Circulating tumor DNA (ctDNA) is a platform to noninvasively ascertain temporal changes in genomic profile. OBJECTIVE: To assess the ctDNA profile in a large cohort of mRCC patients, and to assess changes across patients receiving first-line and later lines of therapy...
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28413126/consensus-statement-of-the-european-urology-association-and-the-european-urogynaecological-association-on-the-use-of-implanted-materials-for-treating-pelvic-organ-prolapse-and-stress-urinary-incontinence
#16
REVIEW
Christopher R Chapple, Francisco Cruz, Xavier Deffieux, Alfredo L Milani, Salvador Arlandis, Walter Artibani, Ricarda M Bauer, Fiona Burkhard, Linda Cardozo, David Castro-Diaz, Jean Nicolas Cornu, Jan Deprest, Alfons Gunnemann, Maria Gyhagen, John Heesakkers, Heinz Koelbl, Sheila MacNeil, Gert Naumann, Jan-Paul W R Roovers, Stefano Salvatore, Karl-Dietrich Sievert, Tufan Tarcan, Frank Van der Aa, Francesco Montorsi, Manfred Wirth, Mohamed Abdel-Fattah
CONTEXT: Surgical nonautologous meshes have been used for several decades to repair abdominal wall herniae. Implantable materials have been adopted for the treatment of female and male stress urinary incontinence (SUI) and female pelvic organ prolapse (POP). OBJECTIVE: A consensus review of existing data based on published meta-analyses and reviews. EVIDENCE ACQUISITION: This document summarises the deliberations of a consensus group meeting convened by the European Association of Urology (EAU) and the European Urogynecological Association, to explore the current evidence relating to the use of polypropylene (PP) materials used for the treatment of SUI and POP, with reference to the 2016 EAU guidelines (European Association of Urology 2016), the European Commission's SCENIHR report on the use of surgical meshes (SCENIHR 2015), other available high-quality evidence, guidelines, and national recommendations...
April 13, 2017: European Urology
https://www.readbyqxmd.com/read/28412065/comparative-effectiveness-of-trimodal-therapy-versus-radical-cystectomy-for-localized-muscle-invasive-urothelial-carcinoma-of-the-bladder
#17
Thomas Seisen, Maxine Sun, Stuart R Lipsitz, Firas Abdollah, Jeffrey J Leow, Mani Menon, Mark A Preston, Lauren C Harshman, Adam S Kibel, Paul L Nguyen, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
Given the lack of randomized evidence comparing trimodal therapy (TMT) to radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB), we performed an observational cohort study to examine the comparative effectiveness of these two definitive treatments. Within the National Cancer Data Base (2004-2011),we identified 1257 (9.8%) and 11 586 (90.2%) patients who received TMT and RC, respectively. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier analysis showed that median overall survival (OS) was similar between the TMT (40 mo, 95% confidence interval [CI] 34-46) and RC groups (43 mo 95% CI 41-45; p=0...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28412064/re-diagnostic-accuracy-of-multi-parametric-magnetic-resonance-imaging-and-transrectal-ultrasound-biopsy-in-prostate-cancer-promis-a-paired-validating-confirmatory-study
#18
https://www.readbyqxmd.com/read/28412063/diagnostic-performance-of-magnetic-resonance-imaging-for-the-detection-of-bone-metastasis-in-prostate-cancer-a-systematic-review-and-meta-analysis
#19
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
CONTEXT: Magnetic resonance imaging (MRI) has been tested for detecting bone metastasis and has shown promising results. Yet, consensus has not been reached regarding whether it can replace the role of bone scintigraphy in this clinical setting or not. OBJECTIVE: To review the diagnostic performance of contemporary (≥1.5 T) MRI for the detection of bone metastasis in patients with prostate cancer. EVIDENCE ACQUISITION: MEDLINE and EMBASE were searched up to January 22, 2017...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28412062/development-and-internal-validation-of-a-novel-model-to-identify-the-candidates-for-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#20
Giorgio Gandaglia, Nicola Fossati, Emanuele Zaffuto, Marco Bandini, Paolo Dell'Oglio, Carlo Andrea Bravi, Giuseppe Fallara, Francesco Pellegrino, Luigi Nocera, Pierre I Karakiewicz, Zhe Tian, Massimo Freschi, Rodolfo Montironi, Francesco Montorsi, Alberto Briganti
BACKGROUND: Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND). OBJECTIVE: To update a nomogram predicting LNI in contemporary PCa patients with detailed biopsy reports. DESIGN, SETTING, AND PARTICIPANTS: Overall, 681 patients with detailed biopsy information, evaluated by a high-volume uropathologist, treated with radical prostatectomy and ePLND between 2011 and 2016 were identified...
April 12, 2017: European Urology
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