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European Journal of Pain: EJP

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https://www.readbyqxmd.com/read/28318085/inflammatory-double-hit-model-of-temporomandibular-joint-disorder-with-elevated-ccl2-cxcl9-cxcl10-rantes-and-behavioural-hypersensitivity-in-tnfr1-r2-mice
#1
S L McIlwrath, R Nesemeier, F Ma, H S Oz, L Zhang, K N Westlund
BACKGROUND: Patients with temporomandibular joint disorders (TMD), reactive arthritis and rheumatoid arthritis often have combined etiology of hereditary and microenvironmental factors contributing to joint pain. Multiple clinical and animal studies indicate 'double-hit' inflammatory insults can cause chronic inflammation. The first inflammatory insult primes the immune system and subsequent insults elicit amplified responses. The present 'double hit' study produced a chronic orofacial pain model in mice with genetic deletion of both TNFα receptors (TNFR1/R2-/-), investigating the main nociceptive signalling pathways in comparisons to wild type mice...
March 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28295893/do-older-adults-with-chronic-low-back-pain-differ-from-younger-adults-in-regards-to-baseline-characteristics-and-prognosis
#2
S Manogharan, A Kongsted, M L Ferreira, M J Hancock
BACKGROUND: Low back pain (LBP) in older adults is poorly understood because the vast majority of the LBP research has focused on the working aged population. The aim of this study was to compare older adults consulting with chronic LBP to middle aged and young adults consulting with chronic LBP, in terms of their baseline characteristics, and pain and disability outcomes over 1 year. METHODS: Data were systematically collected as part of routine care in a secondary care spine clinic...
March 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28295825/effectiveness-of-manual-therapy-versus-surgery-in-pain-processing-due-to-carpal-tunnel-syndrome-a-randomized-clinical-trial
#3
C Fernández-de-Las-Peñas, J Cleland, M Palacios-Ceña, S Fuensalida-Novo, C Alonso-Blanco, J A Pareja, F Alburquerque-Sendín
BACKGROUND: People with carpal tunnel syndrome (CTS) exhibit widespread pressure pain and thermal pain hypersensitivity as a manifestation of central sensitization. The aim of our study was to compare the effectiveness of manual therapy versus surgery for improving pain and nociceptive gain processing in people with CTS. METHODS: The trial was conducted at a local regional Hospital in Madrid, Spain from August 2014 to February 2015. In this randomized parallel-group, blinded, clinical trial, 100 women with CTS were randomly allocated to either manual therapy (n = 50), who received three sessions (once/week) of manual therapies including desensitization manoeuvres of the central nervous system, or surgical intervention (n = 50) group...
March 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28272794/rumination-induces-a-pattern-of-attention-characterized-by-increased-vigilance-followed-by-avoidance-of-affective-pain-words
#4
M L Brookes, L Sharpe, B F Dear
BACKGROUND: This study examined the effects of rumination on attentional processes in relation to an acute experimental pain task. In keeping with recent theory and research, it was hypothesized that we would identify a pattern of attentional bias characterized by enhanced initial vigilance followed by avoidance of pain-related stimuli. METHOD: Undergraduate students were randomized to a rumination condition, which received threat-inducing information about the cold pressor task, or a distraction condition...
March 8, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28263427/body-mass-index-and-distribution-of-body-fat-can-influence-sensory-detection-and-pain-sensitivity
#5
O A Tashani, R Astita, D Sharp, M I Johnson
BACKGROUND: The aim of this study was to investigate the influence of body fat percentage and its distribution on sensory detection and pain sensitivity responses to experimentally induced noxious stimuli in otherwise pain-free individuals. METHODS: Seventy-two participants were divided into three equal groups according to their body mass index (BMI: normal, overweight and obese). Percentage body fat was estimated using a four-site skinfold method. Measurements of cold pressor pain threshold, tolerance and intensity; contact thermal sensory detection and heat pain threshold and tolerance (TSA-II - NeuroSensory Analyzer, Medoc); and blunt pressure pain threshold (algometer, Somedic SenseLab AB) were taken at the waist and thenar eminence...
March 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28263013/slow-brushing-reduces-heat-pain-in-humans
#6
J Liljencrantz, I Strigo, D M Ellingsen, H H Krämer, L C Lundblad, S S Nagi, S Leknes, H Olausson
BACKGROUND: C-tactile (CT) afferents are unmyelinated low-threshold mechanoreceptors optimized for signalling affective, gentle touch. In three separate psychophysical experiments, we examined the contribution of CT afferents to pain modulation. METHODS: In total, 44 healthy volunteers experienced heat pain and CT optimal (slow brushing) and CT sub-optimal (fast brushing or vibration) stimuli. Three different experimental paradigms were used: Concurrent application of heat pain and tactile (slow brushing or vibration) stimulation; Slow brushing, applied for variable duration and intervals, preceding heat pain; Slow versus fast brushing preceding heat pain...
March 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28263010/bilateral-analgesic-effects-of-abobotulinumtoxina-dysport-%C3%A2-following-unilateral-administration-in-the-rat
#7
C Favre-Guilmard, P-E Chabrier, M Kalinichev
BACKGROUND: In addition to inhibition of muscle and glandular hyperactivity, botulinum neurotoxin (BoNT) type A also interferes with pain processing. Previously, in a rat model of paclitaxel-induced polyneuropathy, abobotulinumtoxinA (aboBoNT-A) elicited analgesic effects not only in the injected paw, but also in the contralateral, non-injected paw. METHODS: Here, we assessed bilateral analgesic effects of unilateral aboBoNT-A in several chronic pain models in Sprague-Dawley rats...
March 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28230331/the-development-and-assessment-of-the-worry-about-pain-questionnaire
#8
J C Lefebvre, M P Jensen, S J Waters, I R Molton, F J Keefe, D S Caldwell
BACKGROUND: Worry can be conceptualized as a cognitive-affective automatic process initiated in order to address uncertainty and potential personal inadequacies that could result in negative outcomes. The purpose of the current study was to develop a measure of pain-specific worry - the Worry About Pain Questionnaire (WAPQ). METHOD: In study 1, responses of 335 pain-free participants were used to complete an item analysis and exploratory factors analysis to develop and assess the internal structure of the WAPQ...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28230300/opposite-patterns-of-change-in-perception-of-imagined-and-physically-induced-pain-over-the-course-of-repeated-thermal-stimulations
#9
B Gács, T Szolcsányi, Á Csathó
BACKGROUND: Individuals frequently show habituation to repeated noxious heat. However, given the defensive function of human pain processing, it is reasonable to assume that individuals anticipate that they would become increasingly sensitive to repeated thermal pain stimuli. No previous studies have, however, been addressed to this assumption. Therefore, in the current study, we investigated how healthy human individuals imagine the intensity of repeated thermal pain stimulations, and compared this with the intensity ratings given after physically induced thermal pain trials...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28230292/age-related-changes-in-pain-sensitivity-in-healthy-humans-a-systematic-review-with-meta-analysis
#10
REVIEW
H El Tumi, M I Johnson, P B F Dantas, M J Maynard, O A Tashani
Literature suggests that pain perception diminishes in old age. The most recent review used search strategies conducted over a decade ago and concluded that study findings were equivocal. The aim of this systematic review, with meta-analysis, was to determine age-related changes in pain sensitivity in healthy pain-free adults, children and adolescents. A search of PubMed, Science Direct, and PsycINFO identified studies that compared pain sensitivity response to noxious stimuli at different time points in the lifespan of healthy individuals...
February 23, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28211588/is-this-back-pain-killing-me-all-cause-and-cardiovascular-specific-mortality-in-older-danish-twins-with-spinal-pain
#11
M Fernandez, E Boyle, J Hartvigsen, M L Ferreira, K M Refshauge, C G Maher, K Christensen, J L Hopper, P H Ferreira
BACKGROUND: Few studies have examined the potentially reduced life expectancy associated with spinal pain (i.e. low back and neck pain) in an ageing population, particularly after controlling for familial factors, including genetics. METHODS: We investigated whether spinal pain increased the rate of all-cause and disease-specific cardiovascular mortality in older Danish twins aged ≥70 years. Data from 4391 participants collected at baseline were linked with the Danish Cause of Death Registry with the study ending on 31 December 2014...
February 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28211587/histaminergic-and-non-histaminergic-elicited-itch-is-attenuated-in-capsaicin-evoked-areas-of-allodynia-and-hyperalgesia-a-healthy-volunteer-study
#12
H H Andersen, J Elberling, N Sharma, L E Hauberg, P Gazerani, L Arendt-Nielsen
BACKGROUND: Chronic pain patients with sensitization may exhibit decreased sensitivity to normally pruritogenic sensory stimuli and moreover occasionally perceive these as painful. This study explored the relationship between itch and pain, by evaluating histaminergic and non-histaminergic itch evoked in capsaicin-induced allodynic and hyperalgesic areas. METHODS: In 28 healthy volunteers, capsaicin (100 μg/0.1 mL) was injected intradermally in the volar forearm to establish secondary dysesthesias...
February 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28207186/skin-conductance-as-a-pain-assessment-tool-during-chest-tube-removal-an-observational-study
#13
J O Hansen, H Storm, A Boglino-Hörlin, M Le Guen, E Gayat, M Fischler
BACKGROUND: Skin conductance variability to assess pain has shown varying results. Skin conductance responses per second (SCR) during a standardized painful stimulus in awake adults may give further understanding of the method's validity. The purpose of this study was to validate the SCR with the visual analogue scale (VAS) for pain (P-VAS) and anxiety (A-VAS) during chest tube removal (CTR). METHODS: Ninety-five patients receiving epidural or non-epidural treatment, scheduled for CTR, were studied...
February 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28207185/age-related-changes-in-laser-evoked-potentials-following-trigeminal-and-hand-stimulation-in-healthy-subjects
#14
M de Tommaso, K Ricci, A Montemurno, E Vecchio
OBJECTIVE: This study aimed to evaluate age-related changes in laser-evoked potential (LEP) features, including habituation, via trigeminal and hand stimulation in a large group of healthy volunteers. METHODS: We recorded the LEPs by right-hand stimulation in 237 healthy subjects and by stimulation of the right supraorbital zone in 170 cases. The subjects ranged in age from 7 to 72 years and were divided into six groups by age. RESULTS: At the trigeminal level, the N2 and P2 latencies were significantly shorter and the N2-P2 amplitude was significantly larger in the 7-17 age group than in the other groups...
February 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28185371/do-depression-and-anxiety-profiles-over-time-predict-persistent-post-surgical-pain-a-study-in-cardiac-surgery-patients
#15
M Gabrielle Pagé, J Watt-Watson, M Choinière
BACKGROUND: Rates of depression and anxiety in cardiac surgery patients are higher than in the general population. The development of persistent post-surgical pain (PPSP) in this population is also concerning. The objectives of this study were to (1) identify anxiety and depression trajectories of cardiac surgery patients over a 2-year period; (2) examine demographic and clinical characteristics associated with trajectory memberships and (3) determine if anxiety and/or depression trajectories predict PPSP...
February 10, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28182316/tissue-mechanics-during-temporal-summation-of-sequentially-cuff-pressure-induced-pain-in-healthy-volunteers-and-patients-with-painful-osteoarthritis
#16
B Manafi-Khanian, K Kjaer Petersen, L Arendt-Nielsen
BACKGROUND: The phenomenon of temporal summation to repetitive pressure pain stimuli is an important central neural mechanism for pain intensity encoding. This study evaluated the time-dependent behaviour of mechanical characteristics of soft tissue during repeated cuff stimulation used for eliciting temporal summation of cuff pressure-evoked pain. Such information of tissue mechanics is important for the interpretation of the pain response evoked during sequential stimulations. METHODS: Temporal summation was assessed in 16 subjects separated into two groups (healthy controls and severe knee osteoarthritis patients) using a visual analogue scale during 10 repetitive painful cuff stimuli (1-s duration, 1-s break) of the lower leg...
February 9, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28182310/ankyrin-rich-membrane-spanning-protein-as-a-novel-modulator-of-transient-receptor-potential-vanilloid-1-function-in-nociceptive-neurons
#17
J Peter, C Kasper, M Kaufholz, R Buschow, J Isensee, T Hucho, F W Herberg, F Schwede, C Stein, S-E Jordt, M Brackmann, V Spahn
BACKGROUND: The ion channel TRPV1 is mainly expressed in small diameter dorsal root ganglion (DRG) neurons, which are involved in the sensation of acute noxious thermal and chemical stimuli. Direct modifications of the channel by diverse signalling events have been intensively investigated, but little is known about the composition of modulating macromolecular TRPV1 signalling complexes. Here, we hypothesize that the novel adaptor protein ankyrin-rich membrane spanning protein/kinase D interacting substrate (ARMS) interacts with TRPV1 and modulates its function in rodent DRG neurons...
February 9, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28169489/psychological-and-endocrine-factors-and-pain-after-mastectomy
#18
D Nishimura, S Kosugi, Y Onishi, N Ihara, K Wakaizumi, H Nagata, T Yamada, T Suzuki, S Hashiguchi, H Morisaki
BACKGROUND: This prospective study was designed to examine the associations of demographic, clinical, psychological and neuroendocrine factors with acute and chronic post-operative pain following partial mastectomy. METHODS: Sixty-four female patients scheduled for partial mastectomy were enrolled. Pre-operative anxiety/depression was assessed, using the Hospital Anxiety and Depression Scale (HADS). Pre-operative 24-h urinary cortisol levels were measured 2 days before surgery...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28169487/endogenous-analgesic-effect-of-pregabalin-a-double-blind-and-randomized-controlled-trial
#19
S Sugimine, S Saito, T Araki, K Yamamoto, H Obata
BACKGROUND: Conditioned pain modulation (CPM) is widely used to measure endogenous analgesia, and a recent study indicated that drugs that act on endogenous analgesia are more effective in individuals with lower CPM. Recent animal studies have indicated that pregabalin activates endogenous analgesia by stimulating the descending pain inhibitory system. The present study examined whether the analgesic effect of pregabalin is greater in individuals with lower original endogenous analgesia using CPM...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28169480/pain-patients-letters-the-visit-before-the-visit-a-qualitative-analysis-of-letters-from-patients-referred-to-a-tertiary-pain-center
#20
S Perrot, A Launay, D Desjeux, C Cedraschi
BACKGROUND: Pain centers manage only selected patients, and have long waiting lists. Some patients spontaneously send letters, before the visit, and these letters represent the first contact between the patients and the pain centers. We report a study of the content and format of these letters, for a patient perspective analysis. METHODS: During a 3 month-period, all newly referred patients to a tertiary pain center were considered. If a patient letter was provided, it was collected for analysis...
February 7, 2017: European Journal of Pain: EJP
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