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European Journal of Pain: EJP

Sajjad Rahimi Pordanjani, Sohrab Iranpour, Siamak Sabour
We were interested to read the recent paper by Foxen-Craft E and colleagues published online in Jul 2018 in the Eur J Pain. (Foxen et al., 2018). The authors aimed to explore the reliability and validity of a pain body map among youth with orthopedic conditions before surgery. Youth ages 10-17 years completed the body map and other self-reported outcomes at their preoperative clinic visit and at their day of surgery. Percent agreement and Kappa statistics were used to examine the discrepancy of children's pain location reports between baseline and second assessments This article is protected by copyright...
September 17, 2018: European Journal of Pain: EJP
S Nencini, J Thai, J Ivanusic
BACKGROUND: Pathologies that affect the bone marrow have a significant inflammatory component; however, it is not clear how inflammatory mediators affect nociceptive nerve terminals within the marrow cavity. METHODS: In this study, an in vivo bone-nerve preparation was used to directly record the physiological response properties of bone marrow nociceptors innervating the tibial marrow cavity of rats, before and after application of the inflammatory agent carrageenan...
September 15, 2018: European Journal of Pain: EJP
Krste Boric, Antonia Jelicic Kadic, Matija Boric, Melissa Zarandi-Nowroozi, Dora Jakus, Marija Cavar, Svjetlana Dosenovic, Milka Jeric, Marijan Batinic, Igor Vukovic, Livia Puljak
BACKGROUND: We analysed outcome domains and pain outcome measures in randomized controlled trials of interventions for postoperative pain management in children and adolescents and compared them to the core outcome set recommended by the Pediatric Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (PedIMMPACT). METHODS: Systematic literature search was conducted in MEDLINE, CDSR, DARE, CINAHL and PsycINFO up to 31 January 2017. One author extracted data and second verified the extraction...
September 4, 2018: European Journal of Pain: EJP
L Wood, P Hendrick
BACKGROUND AND OBJECTIVE: Pain neuroscience education (PNE) has shown promising ability in previous reviews to improve pain and disability in chronic low back pain (CLBP). This review aimed to evaluate randomised controlled trials comparing the effectiveness of PNE on pain and disability in CLBP. DATABASES AND DATA TREATMENT: A systematic search was performed using the databases of EBSCO, Medline, Cochrane and Web of Science. Meta-analysis was performed using the RevMan 5...
September 4, 2018: European Journal of Pain: EJP
Minoru Tsuji, Iwao Arai, Kazuya Miyagawa, Hiroko Miyagishi, Atsumi Saito, Kotaro Takeda, Hiroshi Takeda, Nobutake Akiyama, Saburo Saito
BACKGROUND: Morphine is an effective analgesic for the treatment of severe pain, but it can causes itching in patients. In the present study, we examined the possible involvement of interleukin-31 (IL-31) receptor A (IL-31RA) on the morphine-induced itching and antinociception in mice. METHODS: Long-lasting scratching (LLS) and short-lasting scratching (SLS) were estimated as an indicator of itching and nonspecific behavior, respectively, and antinociception was evaluated using a hot-plate test in mice...
September 3, 2018: European Journal of Pain: EJP
Adrián Pérez-Aranda, Jennifer Hofmann, Albert Feliu-Soler, Carmen Ramírez-Maestre, Laura Andrés-Rodríguez, Willibald Ruch, Juan V Luciano
BACKGROUND AND OBJECTIVE: The link between humor and sense of humor with pain has been a topic of research for decades. The purpose of the present article is to review the different studies that have been conducted to date on the association between humor and sense of humor with pain. DATABASES AND DATA TREATMENT: The literature search was conducted using the PubMed, Science Direct, and ProQuest databases. Forty-two studies were reviewed and the results are summarized and structured into three sections: experimental pain, chronic pain, and pain in children...
September 3, 2018: European Journal of Pain: EJP
Helen R Gilpin, Daniel R Stahl, Lance M McCracken
BACKGROUND: Psychological treatments are known to be effective for chronic pain, but little is understood about which patients are most likely to benefit from which ones. METHODS: The study reported here included 609 people who attended a residential, interdisciplinary, pain management programme based on Acceptance and Commitment Therapy between January 2012 and August 2014. A flexible and theoretically guided approach to model building based on fractional polynomials was used to identify potential predictors of outcome in domains of emotional, physical, and social functioning, and pain intensity...
September 3, 2018: European Journal of Pain: EJP
J R Zadro, D Shirley, G E Duncan, P H Ferreira
BACKGROUND: It is unknown how familial factors influence the recovery from low back pain (LBP) and the maintenance activity behaviours. We aimed to investigate whether individual and within-family physical activity (PA) and sedentary behaviour influenced recovery from LBP, and maintenance of PA and sedentary behaviour in people with and without LBP. METHODS: Longitudinal logistic regression analyses were performed on adult twins from the Washington State Twin Registry...
September 3, 2018: European Journal of Pain: EJP
T da Silva, P Macaskill, A Kongsted, K Mills, C G Maher, M J Hancock
BACKGROUND: The prognosis of acute low back pain (LBP) is typically good; however, there is substantial variation in individual patient's outcomes. We recently developed a prediction model that was able to predict the likelihood of pain recovery in patients with acute LBP who continue to have pain approximately 1-week after initially seeking care. The aims of the current study were to: a) re-categorize the variables in the developmental dataset to be able to validate the model in the validation dataset; b) refit the existing model in the developmental dataset and c) validate the model in the validation dataset...
August 24, 2018: European Journal of Pain: EJP
Catherine E Ferland, Alisson R Teles, Pablo Ingelmo, Neil Saran, Serge Marchand, Jean A Ouellet
BACKGROUND: Monoaminergic pathways are involved in the process of pain inhibition and facilitation. The objective of this study was to investigate the role of blood monoamines as biomarkers of conditioned pain modulation (CPM) efficacy. METHODS: One hundred and five paediatric patients with chronic back pain were enrolled in this observational study. The protocol involved dosage of plasma monoamines (dopamine, DOPA; serotonin, 5-HT; epinephrine, Epi; norepinephrine, NE; metanephrine, ME; and normetanephrine, NME) and clinical assessment (CPM, functional disability, pain, sleep quality, anxiety and depression)...
August 19, 2018: European Journal of Pain: EJP
David Kang, James H McAuley, Mustafa S Kassem, Justine M Gatt, Sylvia M Gustin
BACKGROUND AND OBJECTIVE: Alterations in the gray matter volume of several brain regions have been reported in people with chronic pain. The most consistent observation is a decrease of gray matter volume in the medial prefrontal cortex. These findings are important as the medial prefrontal cortex plays a critical role in emotional and cognitive processing in chronic pain. Although a logical cause of gray matter volume decrease may be neurodegeneration, this is not supported by the current evidence...
August 12, 2018: European Journal of Pain: EJP
Inese Gobina, Jari Villberg, Raili Välimaa, Jorma Tynjälä, Ross Whitehead, Alina Cosma, Fiona Brooks, Franco Cavallo, Kwok Ng, Margarida Gaspar de Matos, Anita Villerusa
BACKGROUND: Reports of the overall chronic pain prevalence and its associated demographic characteristics among adolescents vary greatly across existing studies. Using internationally comparable data, this study investigates age, sex and country-level effects in the prevalence of chronic single-site and multi-site pain among adolescents during the last six months preceding the survey. METHODS: Data (n = 214,283) from the 2013/2014 Health Behaviour in School-aged Children (HBSC) study were used including nationally representative samples of 11-, 13- and 15-year-olds from general schools in 42 participating countries...
August 11, 2018: European Journal of Pain: EJP
Bettina Böttcher, Elke R Gizewski, Christian Siedentopf, Ruth Steiger, Michael Verius, David Riedl, Anja Ischebeck, Julia Schmid, Ludwig Wildt, Sigrid Elsenbruch
BACKGROUND: Chronic pelvic pain, in particular dysmenorrhoea, is a significant yet unresolved healthcare problem in gynaecology. As interoceptive sensitivity and underlying neural mechanisms remain incompletely understood, this functional magnetic resonance imaging (fMRI) study assessed behavioural and neural responses to visceral stimuli in primary dysmenorrhoea (PMD). METHODS: Women with PMD (N = 19) without psychological comorbidity and healthy women (N = 20) were compared with respect to visceral sensory and pain thresholds, and to neural responses to individually calibrated mildly painful and painful rectal distensions implemented during scanning...
August 11, 2018: European Journal of Pain: EJP
Claudia Pitzer, Carmen La Porta, Rolf-Detlef Treede, Anke Tappe-Theodor
BACKGROUND: Chronic pain is often accompanied by comorbidities like anxiety and depression. The temporal correlations, as well as the underlying mechanisms of these reciprocal correlations, are unclear. Moreover, preclinical studies examining emotional behaviour are very controversial, and a chronological analysis of anxiety-like behaviour in mouse pain models considering both genders has not been performed so far. METHODS: We used several behavioural tests to assess and validate anxiety-like behaviour in complete Freund's adjuvant (CFA) and spared nerve injury (SNI) pain models in C57BL/6 mice...
August 11, 2018: European Journal of Pain: EJP
Ainhoa Coloma-Carmona, José Luis Carballo, Jesús Rodríguez-Marín, Carlos Javier van-der Hofstadt
BACKGROUND: Withdrawal symptoms have been widely shown to be a useful indicator of the severity of opioid dependence. One of the most used instruments to assess them is the Adjective Rating Scale for Withdrawal (ARSW). However, there is a lack of adaptations and validations for its use with prescription opioids, even less for chronic pain patients under treatment with these analgesics. Thus, the aims of this study were to analyse the psychometric properties and invariance across gender of the ARSW in a sample of chronic noncancer pain patients...
August 10, 2018: European Journal of Pain: EJP
T Fung, Y I Asiri, K Taheri, R Wall, S K W Schwarz, E Puil, B A MacLeod
BACKGROUND: Neuraxial opioids are widely used for intraoperative and postoperative analgesia. The risk of severe adverse effects including respiratory depression accompanies this analgesia, prompting the need for effective non-opioid alternatives. Systemic 1-amino-1-cyclobutanecarboxylic acid showed promise in preliminary studies to produce antinociception without observable toxicity. However, the effects of 1-amino-1-cyclobutanecarboxylic acid after intrathecal administration are unknown...
August 9, 2018: European Journal of Pain: EJP
Ryan Patel, Mateusz Kucharczyk, Carlota Montagut-Bordas, Stevie Lockwood, Anthony H Dickenson
BACKGROUND: The term 'irritable nociceptor' was coined to describe neuropathic patients characterized by evoked hypersensitivity and preservation of primary afferent fibres. Oxcarbazepine is largely ineffectual in an overall patient population, but has clear efficacy in a subgroup with the irritable nociceptor profile. We examine whether neuropathy in rats induced by spinal nerve injury shares overlapping pharmacological sensitivity with the irritable nociceptor phenotype using drugs that target sodium channels...
August 9, 2018: European Journal of Pain: EJP
Laurent Misery, Henri Duboc, Benoit Coffin, Emilie Brenaut, Flavien Huet, Charles Taieb
BACKGROUND: Irritable bowel and sensitive skin syndromes are common painful conditions that are poorly understood, with alterations of the peripheral (and possibly central) nervous system that lead to a lowering of perception thresholds as the main pathophysiological mechanism. METHODS: A cross-sectional epidemiological study was carried out on a representative sample of French people, according to the quota method using a questionnaire. RESULTS: Among the 5,000 respondents, 48...
August 3, 2018: European Journal of Pain: EJP
Michael Melia, Britta Geissler, Jochem König, Hans Jürgen Ottersbach, Matthias Umbreit, Stefan Letzel, Axel Muttray
BACKGROUND: The assessment of pressure pain has become an integral part in pain research. The distribution of pressure under a plunger can be uneven. However, measurements based on conventional devices show the applied force or mean pressure, failing to take local pressure peaks into account. Our main question was whether peak pressures under the probe are responsible for pain onset. METHODS: A force-controlled algometer was fitted with a newly developed pressure-indicating film...
August 3, 2018: European Journal of Pain: EJP
Juliane Traxler, Marjolein M Hanssen, Stefan Lautenbacher, Fabian Ottawa, Madelon L Peters
BACKGROUND: Previous studies found evidence that dispositional optimism is related to lower pain sensitivity. Recent findings suggest that temporarily increasing optimism by means of imagining a positive future may also have pain-alleviating effects. OBJECTIVES: The present experiment was designed to investigate conditioned pain modulation (CPM) as a potential underlying mechanism of this pain-alleviating effect of induced optimism. METHODS: For this purpose, 45 healthy participants were randomized into an optimistic or neutral imagery condition...
August 3, 2018: European Journal of Pain: EJP
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