Read by QxMD icon Read

European Journal of Pain: EJP

B M Fitzgibbon, K E Hoy, L A Knox, E K Guymer, G Littlejohn, D Elliot, L E Wambeek, S McQueen, K A Elford, S J Lee, P G Enticott, P B Fitzgerald
BACKGROUND: Fibromyalgia is a complex chronic disorder with few effective treatments currently available. One promising treatment option is repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive brain stimulation technique that has shown promise in disorders effecting the central nervous system. METHODS: We assessed the efficacy of a course of high-frequency (10Hz) left-hemisphere dorsolateral prefrontal cortex (DLPFC) rTMS in 26 patients (14 active; 12 sham) with a diagnosis of fibromyalgia...
March 15, 2018: European Journal of Pain: EJP
D Keszthelyi, Q Aziz, J K Ruffle, O O'Daly, D Sanders, K Krause, S C Williams, M A Howard
BACKGROUND: Traditional psychometric measures aimed at characterizing the pain experience often show considerable overlap, due to interlinked affective and modulatory processes under central nervous system control. Neuroimaging studies have been employed to investigate this complexity of pain processing, in an attempt to provide a quantifiable, adjunctive description of pain perception. In this exploratory study, we examine psychometric and neuroimaging data from 38 patients with painful osteoarthritis of the carpometacarpal joint...
March 9, 2018: European Journal of Pain: EJP
Y Fu, G Yu, E McNichol, K Marczewski, S J Closs
BACKGROUND: Self-management is recommended for patients with chronic back pain. Health professionals' support for self-management can be more effective when working in partnership with patients. The aim of this study was to investigate the associations between patient-professional partnerships and the self-management of chronic back pain. METHODS: An explanatory sequential mixed methods study was undertaken. Adults with chronic back pain referred to pain management clinics participated at baseline and three-month follow-up...
March 5, 2018: European Journal of Pain: EJP
E Sjögren, T Kullenberg, B Jonzon, M Segerdahl, O Stålberg, M M Halldin, A K Sundgren-Andersson
BACKGROUND: The transient receptor potential cation channel subfamily V 1 (TRPV1) is involved in nociception and has thus been of interest for drug developers, as a target for novel analgesics. However, several oral TRPV1 antagonists have failed in development, and novel approaches to target TRPV1 with innovative chemistry are needed. METHOD: This work describes an intradermal microdosing approach in humans for pharmacodynamic deductions and pharmacological profiling of compounds...
March 5, 2018: European Journal of Pain: EJP
Falk von Dincklage, Axel Jakuscheit, Johannes Weth, Gregor Lichtner, Carlo Jurth, Benno Rehberg-Klug
We would like to thank for the opportunity to reply to the important questions raised by Kendall et al. and also would like to thank the authors of that letter for their kind words. Our results indeed seem contrary to previous results about opioid-induced hyperalgesia (OIH), but on a detailed look there is not necessarily a contradiction. Until now no direct link between the short-lasting OIH and long-term pain has been shown in humans. This article is protected by copyright. All rights reserved.
February 18, 2018: European Journal of Pain: EJP
M C Basch, E T Chow, D E Logan, D Borsook, N L Schechter, L E Simons
BACKGROUND: The experience of persistent pain in multiple locations is common in youth. Based on current literature, youth with multiple pain sites (MPS) are at risk of experiencing poorer emotional outcomes and a spread of symptoms into late adolescence and adulthood. Little is known regarding the association between MPS with physical and school functioning domains, particularly after initiation of multidisciplinary pain treatment. Therefore, the objective of this study was to examine the association of MPS with disability and school functioning among youth with chronic pain...
February 13, 2018: European Journal of Pain: EJP
N E Van Loey, I Klein, A E E de Jong, H W C Hofland, E Vandermeulen, I M Engelhard
BACKGROUND: Pain and PTSD symptoms are significant problems in the aftermath of a burn injury and they often co-occur. Catastrophizing has been linked to both phenomena. The aim of this study was to investigate the underlying role of catastrophizing in PTSD symptoms and pain following burns. METHODS: This prospective study included 216 patients with burns. PTSD symptoms and pain were measured during hospitalization (T1) and 6 (T2) and 12 months (T3) postburn. The Impact of Event Scale-Revised (IES-R) indexed PTSD symptoms...
February 13, 2018: European Journal of Pain: EJP
J Wager, L Stahlschmidt, F Heuer, S Troche, B Zernikow
BACKGROUND: School-based health education programs on chronic pain providing information about the proper management of recurrent and chronic pain may increase health literacy in terms of pain knowledge, may thereby prevent dysfunctional coping and may decrease the risk of pain chronification. The aim of the present feasibility study was to evaluate the effectiveness of an educational movie on recurrent and chronic pain in increasing pain knowledge among students. METHODS: N = 95 adolescent students provided demographic and pain-related information and completed a pain knowledge questionnaire before and after viewing an educational movie on recurrent and chronic pain...
February 13, 2018: European Journal of Pain: EJP
J Maarrawi, J Abdel Hay, S Kobaiter-Maarrawi, P Tabet, R Peyron, L Garcia-Larrea
BACKGROUND: Amitriptyline has well-established efficacy in several chronic pain conditions. While optimal treatment for chronic neck pain (CNP) remains controversial, amitriptyline was not tested for CNP. We evaluated the effect of bedtime amitriptyline in the management of CNP. METHODS: 220 patients suffering from idiopathic CNP were randomized to receive either placebo pill (n = 108) or 5 mg of amitriptyline (n = 112) at bedtime for two months. Primary outcome measure was visual analog scale (VAS) for pain...
February 13, 2018: European Journal of Pain: EJP
E Ikeda, T Li, H Kobinata, S Zhang, J Kurata
BACKGROUND: Chronification of pain is associated with both anatomical and functional alterations of the brain. Alteration in regional gray matter volume might potentially be associated with modified activity of specific brain networks. In this cross-sectional, observational study, we sought to identify brain regions with gray matter volume changes in patients with chronic pain and to reveal its significance by analysing alteration in functional connectivity from those regions. We further explored relevance of such alterations with psychometrics of chronic pain...
February 13, 2018: European Journal of Pain: EJP
S K Totsch, R Y Meir, T L Quinn, S A Lopez, B A Gower, R E Sorge
SIGNIFICANCE: Obesity may increase susceptibility to chronic pain often due to poor diet. Diet has potential to be used as treatment for pain. The current study investigates the use of a novel translatable diet to act as a preventative (i.e., prior to surgery) or an intervention (i.e., following an injury). BACKGROUND: Obesity and chronic pain are prevalent concerns. Pain is frequently experienced in weight bearing joints, but is common in other areas of the body as well, suggesting other factors...
February 13, 2018: European Journal of Pain: EJP
Eivind Hasvik, Anne Julsrud Haugen, Johannes Gjerstad, Lars Grøvle
BACKGROUND: Low back-related leg pain with nerve root involvement is conceptually regarded as a neuropathic condition. However, it is uncertain to what extent patients with this condition can be formally classified with neuropathic pain. METHOD: First, we used the 2016 revision of the IASP Special Interest Group on Neuropathic Pain (NeuPSIG) grading system for neuropathic pain to grade patients suffering from low back-related leg pain and a corresponding disc herniation with either unlikely, possible, probable or definite neuropathic pain...
February 13, 2018: European Journal of Pain: EJP
M L Plinsinga, B K Coombes, R Mellor, P Nicolson, A Grimaldi, P Hodges, K Bennell, B Vicenzino
BACKGROUND: Gluteal tendinopathy is the most common lower limb tendinopathy presenting to general practice. It has a high prevalence among middle-aged females and impacts on daily activities, work participation and quality of life. The aim was to compare physical and psychological characteristics between subgroups of severity of pain and disability. METHODS: A multi-centre cross-sectional cohort of 204 participants (mean age 55 years, 82% female) who had a clinical diagnosis of gluteal tendinopathy with MRI confirmation were assessed...
February 9, 2018: European Journal of Pain: EJP
H Chiang, K-C Chang, H-W Kan, S-W Wu, M-T Tseng, H-W Hsueh, Y-H Lin, C-C Chao, S-T Hsieh
BACKGROUND: The study aimed to investigate the physiology, psychophysics, pathology and their relationship in reversible nociceptive nerve degeneration, and the physiology of acute hyperalgesia. METHODS: We enrolled 15 normal subjects to investigate intraepidermal nerve fibre (IENF) density, contact heat-evoked potential (CHEP) and thermal thresholds during the capsaicin-induced skin nerve degeneration-regeneration; and CHEP and thermal thresholds at capsaicin-induced acute hyperalgesia...
February 2, 2018: European Journal of Pain: EJP
Y-J Lue, H-H Wang, K-I Cheng, C-H Chen, Y-M Lu
BACKGROUND: Thermal detection thresholds and thermal pain thresholds are important in quantitative sensory testing. Although they have been well studied for assessing somatosensory function, the investigation of thermal pain tolerance has been insufficient. The aim of this study was to explore the characteristics of thermal pain tolerance and pain ratings in healthy subjects. METHODS: Cold pain tolerance (CPTol) and heat pain tolerance (HPTol) were tested in 213 healthy adults aged 18-81 years recruited from the local community...
February 1, 2018: European Journal of Pain: EJP
S A Mohamed, D M Sayed, F A El Sherif, A M Abd El-Rahman
BACKGROUND AND OBJECTIVES: Postoperative pain and stress elicit hormonal changes. We aimed at comparing the effects of wound infiltration with ketamine versus dexmedetomidine on postoperative pain and stress response. METHODS: This double-blinded study included ninety patients scheduled for total abdominal hysterectomy and were randomly assigned into three groups to receive local wound infiltration with 40 mL of 0.25% bupivacaine (group C), plus 2 mg/kg ketamine (group K) or 2 μg/kg dexmedetomidine (group D)...
February 1, 2018: European Journal of Pain: EJP
P Hansson, T S Jensen, G Kvarstein, M Strömberg
CONTEXT: Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. OBJECTIVE: To determine whether treatment and re-treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. METHODS: Three non-interventional, observational studies were concurrently conducted in Denmark, Norway and Sweden...
February 1, 2018: European Journal of Pain: EJP
M K Marttinen, N Santavirta, M J Kauppi, H Pohjankoski, H Vuorimaa
OBJECTIVE: The Pain Coping Questionnaire (PCQ), the first validated pain coping measurement developed specifically for children, has lacked proper validation in Finnish. The original PCQ by Reid et al. (Pain 1998; 76; 83-96) comprises eight-first-order and three higher-order scales. The aim herein was to determine the factor structure and validity of the Finnish PCQ translation in Finnish children. METHODS: Exploratory factor analysis was used for the first-order and higher-order classification of 91 recruited patients aged 8-15...
February 1, 2018: European Journal of Pain: EJP
L Reist, J Erlenwein, W Meissner, T Stammschulte, F Stüber, U M Stamer
PURPOSE: Nonopioid analgesics are frequently used for the treatment of acute and chronic pain. Dipyrone is an alternative to NSAIDs and paracetamol, however, data on the frequency of its usage by anaesthesiologists in the perioperative and chronic pain setting are lacking and its adverse reactions are a matter of debate. METHODS: The link to a questionnaire on the use of nonopioid analgesics (NSAIDs, COX-2 inhibitors, paracetamol, dipyrone) and the safety of dipyrone in the perioperative and chronic pain setting was mailed to anaesthesiologists and pain physicians...
January 29, 2018: European Journal of Pain: EJP
M A Fitzcharles, E Eisenberg
Medical cannabis has entered mainstream medicine and is here to stay. Propelled by public advocacy, the media and mostly anecdote rather than sound scientific study, patients worldwide are exploring marijuana use for a vast array of medical conditions including management of chronic pain. Contrary to the usual path of drug approval, medical cannabis has bypassed traditional evidence-based study and has been legalized as a therapeutic product by legislative bodies in various countries. While there is a wealth of basic science and preclinical studies demonstrating effects of cannabinoids in neurobiological systems, especially those pertaining to pain and inflammation, clinical study remains limited...
January 29, 2018: European Journal of Pain: EJP
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"