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European Journal of Pain: EJP

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https://www.readbyqxmd.com/read/28211588/is-this-back-pain-killing-me-all-cause-and-cardiovascular-specific-mortality-in-older-danish-twins-with-spinal-pain
#1
M Fernandez, E Boyle, J Hartvigsen, M L Ferreira, K M Refshauge, C G Maher, K Christensen, J L Hopper, P H Ferreira
BACKGROUND: Few studies have examined the potentially reduced life expectancy associated with spinal pain (i.e. low back and neck pain) in an ageing population, particularly after controlling for familial factors, including genetics. METHODS: We investigated whether spinal pain increased the rate of all-cause and disease-specific cardiovascular mortality in older Danish twins aged ≥70 years. Data from 4391 participants collected at baseline were linked with the Danish Cause of Death Registry with the study ending on 31 December 2014...
February 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28211587/histaminergic-and-non-histaminergic-elicited-itch-is-attenuated-in-capsaicin-evoked-areas-of-allodynia-and-hyperalgesia-a-healthy-volunteer-study
#2
H H Andersen, J Elberling, N Sharma, L E Hauberg, P Gazerani, L Arendt-Nielsen
BACKGROUND: Chronic pain patients with sensitization may exhibit decreased sensitivity to normally pruritogenic sensory stimuli and moreover occasionally perceive these as painful. This study explored the relationship between itch and pain, by evaluating histaminergic and non-histaminergic itch evoked in capsaicin-induced allodynic and hyperalgesic areas. METHODS: In 28 healthy volunteers, capsaicin (100 μg/0.1 mL) was injected intradermally in the volar forearm to establish secondary dysesthesias...
February 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28207186/skin-conductance-as-a-pain-assessment-tool-during-chest-tube-removal-an-observational-study
#3
J O Hansen, H Storm, A Boglino-Hörlin, M Le Guen, E Gayat, M Fischler
BACKGROUND: Skin conductance variability to assess pain has shown varying results. Skin conductance responses per second (SCR) during a standardized painful stimulus in awake adults may give further understanding of the method's validity. The purpose of this study was to validate the SCR with the visual analogue scale (VAS) for pain (P-VAS) and anxiety (A-VAS) during chest tube removal (CTR). METHODS: Ninety-five patients receiving epidural or non-epidural treatment, scheduled for CTR, were studied...
February 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28207185/age-related-changes-in-laser-evoked-potentials-following-trigeminal-and-hand-stimulation-in-healthy-subjects
#4
M de Tommaso, K Ricci, A Montemurno, E Vecchio
OBJECTIVE: This study aimed to evaluate age-related changes in laser-evoked potential (LEP) features, including habituation, via trigeminal and hand stimulation in a large group of healthy volunteers. METHODS: We recorded the LEPs by right-hand stimulation in 237 healthy subjects and by stimulation of the right supraorbital zone in 170 cases. The subjects ranged in age from 7 to 72 years and were divided into six groups by age. RESULTS: At the trigeminal level, the N2 and P2 latencies were significantly shorter and the N2-P2 amplitude was significantly larger in the 7-17 age group than in the other groups...
February 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28185371/do-depression-and-anxiety-profiles-over-time-predict-persistent-post-surgical-pain-a-study-in-cardiac-surgery-patients
#5
M Gabrielle Pagé, J Watt-Watson, M Choinière
BACKGROUND: Rates of depression and anxiety in cardiac surgery patients are higher than in the general population. The development of persistent post-surgical pain (PPSP) in this population is also concerning. The objectives of this study were to (1) identify anxiety and depression trajectories of cardiac surgery patients over a 2-year period; (2) examine demographic and clinical characteristics associated with trajectory memberships and (3) determine if anxiety and/or depression trajectories predict PPSP...
February 10, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28182316/tissue-mechanics-during-temporal-summation-of-sequentially-cuff-pressure-induced-pain-in-healthy-volunteers-and-patients-with-painful-osteoarthritis
#6
B Manafi-Khanian, K Kjaer Petersen, L Arendt-Nielsen
BACKGROUND: The phenomenon of temporal summation to repetitive pressure pain stimuli is an important central neural mechanism for pain intensity encoding. This study evaluated the time-dependent behaviour of mechanical characteristics of soft tissue during repeated cuff stimulation used for eliciting temporal summation of cuff pressure-evoked pain. Such information of tissue mechanics is important for the interpretation of the pain response evoked during sequential stimulations. METHODS: Temporal summation was assessed in 16 subjects separated into two groups (healthy controls and severe knee osteoarthritis patients) using a visual analogue scale during 10 repetitive painful cuff stimuli (1-s duration, 1-s break) of the lower leg...
February 9, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28182310/ankyrin-rich-membrane-spanning-protein-as-a-novel-modulator-of-transient-receptor-potential-vanilloid-1-function-in-nociceptive-neurons
#7
J Peter, C Kasper, M Kaufholz, R Buschow, J Isensee, T Hucho, F W Herberg, F Schwede, C Stein, S-E Jordt, M Brackmann, V Spahn
BACKGROUND: The ion channel TRPV1 is mainly expressed in small diameter dorsal root ganglion (DRG) neurons, which are involved in the sensation of acute noxious thermal and chemical stimuli. Direct modifications of the channel by diverse signalling events have been intensively investigated, but little is known about the composition of modulating macromolecular TRPV1 signalling complexes. Here, we hypothesize that the novel adaptor protein ankyrin-rich membrane spanning protein/kinase D interacting substrate (ARMS) interacts with TRPV1 and modulates its function in rodent DRG neurons...
February 9, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28169489/psychological-and-endocrine-factors-and-pain-after-mastectomy
#8
D Nishimura, S Kosugi, Y Onishi, N Ihara, K Wakaizumi, H Nagata, T Yamada, T Suzuki, S Hashiguchi, H Morisaki
BACKGROUND: This prospective study was designed to examine the associations of demographic, clinical, psychological and neuroendocrine factors with acute and chronic post-operative pain following partial mastectomy. METHODS: Sixty-four female patients scheduled for partial mastectomy were enrolled. Pre-operative anxiety/depression was assessed, using the Hospital Anxiety and Depression Scale (HADS). Pre-operative 24-h urinary cortisol levels were measured 2 days before surgery...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28169487/endogenous-analgesic-effect-of-pregabalin-a-double-blind-and-randomized-controlled-trial
#9
S Sugimine, S Saito, T Araki, K Yamamoto, H Obata
BACKGROUND: Conditioned pain modulation (CPM) is widely used to measure endogenous analgesia, and a recent study indicated that drugs that act on endogenous analgesia are more effective in individuals with lower CPM. Recent animal studies have indicated that pregabalin activates endogenous analgesia by stimulating the descending pain inhibitory system. The present study examined whether the analgesic effect of pregabalin is greater in individuals with lower original endogenous analgesia using CPM...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28169480/pain-patients-letters-the-visit-before-the-visit-a-qualitative-analysis-of-letters-from-patients-referred-to-a-tertiary-pain-center
#10
S Perrot, A Launay, D Desjeux, C Cedraschi
BACKGROUND: Pain centers manage only selected patients, and have long waiting lists. Some patients spontaneously send letters, before the visit, and these letters represent the first contact between the patients and the pain centers. We report a study of the content and format of these letters, for a patient perspective analysis. METHODS: During a 3 month-period, all newly referred patients to a tertiary pain center were considered. If a patient letter was provided, it was collected for analysis...
February 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28158929/the-analgesic-and-anti-inflammatory-effects-of-salvinorin-a-analogue-%C3%AE-tetrahydropyran-salvinorin-b-in-mice
#11
K F Paton, N Kumar, R S Crowley, J L Harper, T E Prisinzano, B M Kivell
BACKGROUND: Drugs activating the mu opioid receptor are routinely used to treat severe acute and chronic pain. Unfortunately, side effects including nausea, constipation, respiratory depression, addiction and tolerance can limit clinical utility. In contrast, kappa opioid receptor (KOPr) agonists, such as Salvinorin A (SalA), have analgesic properties with little potential for abuse. METHODS: We evaluated SalA and the novel analogue β-tetrahydropyran Salvinorin B (β-THP SalB) for the ability to modulate pain and inflammation in vivo...
February 3, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28146324/psychiatric-comorbidity-in-new-daily-persistent-headache-a-cross-sectional-study
#12
R Uniyal, V K Paliwal, A Tripathi
BACKGROUND: New daily persistent headache (NDPH) is a type of chronic daily headache. NDPH can have migrainous (NDPH-CM) or tension-type character (NDPH-CTTH). Recently, NDPH patients have shown to have associated anxiety and depression. We compared anxiety, depressive symptoms, somatization and pain catastrophization among NDPH, healthy controls and patients with chronic low-back pain and between NDPH-CM and NDPH-CTTH. METHODS: We assessed the study population for depressive symptoms by Patient Health Questionnaire-9, anxiety by Generalized Anxiety Disorder Scale - 7, somatoform disorder using DSM IV (TR) criteria and pain catastrophizing by using Pain Catastrophizing Scale...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28146319/unimpaired-endogenous-pain-inhibition-in-the-early-phase-of-complex-regional-pain-syndrome
#13
N Kumowski, T Hegelmaier, J Kolbenschlag, C Maier, T Mainka, J Vollert, E Enax-Krumova
BACKGROUND: The complex regional pain syndrome (CRPS) is characterized by distal generalisation of pain beyond the initial trauma. This might be the result of impaired endogenous pain inhibition. METHOD: We compared Conditioned Pain Modulation (CPM) between patients with CRPS (n = 24; pain: 4.5 ± 2.2, NRS 0-10; disease duration <1 year), neuralgia (n = 17; pain: 5.5 ± 1.1) and healthy subjects (n = 23) and its correlation with loss and gain of function as assessed by Quantitative Sensory Testing (QST)...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28146318/inhibition-of-%C3%AE-5-subunit-containing-gabaa-receptors-facilitated-spinal-nociceptive-transmission-and-plasticity
#14
M Xue, J P Liu, Y H Yang, Z W Suo, X Yang, X D Hu
BACKGROUND: γ-Aminobutyric acid (GABA) type A receptors (GABAA Rs) locate at both synaptic and extrasynaptic membrane, which generate phasic and tonic inhibition, respectively. In spinal cord dorsal horn, the phasic inhibition produced by transient activation of synaptic GABAA Rs plays an important role in the gating control over nociceptive conveyance. Although extrasynaptic GABAA Rs that contain α5 subunits (α5-GABAA Rs) are also detectable in spinal dorsal horn, much less is known about the function of these receptors...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28146317/attentional-performance-may-help-to-identify-duloxetine-responders-in-chronic-pain-fibromyalgia-patients
#15
G Schmidt, R Alvarenga, A Manhães, S Schmidt
BACKGROUND: Long-term pain affects brain in response to attention tasks. This study aimed to verify the relationship between performance in a computerized visual attention test (CVAT) and response to duloxetine in fibromyalgia patients. Duloxetine is approved for the treatment but the response is not immediate. METHODS: Patients were drawn from a sample of 74 patients with chronic pain. These patients were selected because they kept their subjective perceptions of pain as severe after 1 week of duloxetine treatment...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28146315/brain-changes-associated-with-cognitive-and-emotional-factors-in-chronic-pain-a-systematic-review
#16
REVIEW
A Malfliet, I Coppieters, P Van Wilgen, J Kregel, R De Pauw, M Dolphens, K Ickmans
: An emerging technique in chronic pain research is MRI, which has led to the understanding that chronic pain patients display brain structure and function alterations. Many of these altered brain regions and networks are not just involved in pain processing, but also in other sensory and particularly cognitive tasks. Therefore, the next step is to investigate the relation between brain alterations and pain related cognitive and emotional factors. This review aims at providing an overview of the existing literature on this subject...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28107604/predicting-recovery-in-patients-with-acute-low-back-pain-a-clinical-prediction-model
#17
T da Silva, P Macaskill, K Mills, C Maher, C Williams, C Lin, M J Hancock
BACKGROUND: There is substantial variability in the prognosis of acute low back pain (LBP). The ability to identify the probability of individual patients recovering by key time points would be valuable in making informed decisions about the amount and type of treatment to provide. Predicting recovery based on presentation 1-week after initially seeking care is clinically important and may be more accurate than predictions made at initial presentation. The aim of this study was to predict the probability of recovery at 1-week, 1-month and 3-months after 1-week review in patients who still have LBP 1-week after initially seeking care...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28107599/the-prevalence-and-impact-of-chronic-neuropathic-pain-on-daily-and-social-life-a-nationwide-study-in-a-japanese-population
#18
S Inoue, T Taguchi, T Yamashita, M Nakamura, T Ushida
BACKGROUND: This study marks the first epidemiological evaluation of the prevalence and burden of chronic neuropathic pain (NeP) in an Asian population. The objective of this nationwide cross-sectional study was to identify the characteristics of individuals with NeP, detect the NeP features that affect their quality of life (QOL), and demonstrate the negative effects of NeP on social and daily living as well as comorbidities including depression, anxiety and sleep disorders. METHODS: We mailed a cross-sectional, population-based epidemiological survey to a random nationwide sample of 10,000 Japanese adults over 20 years old...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28107590/endocannabinoid-activation-of-cb1-receptors-contributes-to-long-lasting-reversal-of-neuropathic-pain-by-repetitive-spinal-cord-stimulation
#19
L Sun, L Tai, Q Qiu, R Mitchell, S Fleetwood-Walker, E A Joosten, C W Cheung
BACKGROUND: Spinal cord stimulation (SCS) has been shown to be effective in the management of certain neuropathic pain conditions, however, the underlying mechanisms are incompletely understood. In this study, we investigated repetitive SCS in a rodent neuropathic pain model, revealing long-lasting and incremental attenuation of hyperalgesia and a mechanism of action involving endocannabinoids. METHOD: Animals were implanted with monopolar electrodes at the time of partial sciatic nerve injury...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28106324/verbal-instructions-influence-pain-thresholds-assessment-a-study-using-manual-and-electronic-mechanical-stimulators
#20
K Suzuki, L Baad-Hansen, P Svensson
BACKGROUND: Quantitative sensory testing (QST) relies on psychophysical techniques and instructions to test subjects. This study examined the effect of different verbal instructions for mechanical pain thresholds (MPTs) using two different stimulation techniques; weighted pinprick stimulators and an electronic von Frey device (EvF). The test-retest reliability and within session variability in the MPTs for each verbal instruction were compared in addition. METHODS: Sixteen healthy volunteers participated...
January 20, 2017: European Journal of Pain: EJP
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