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European Journal of Pain: EJP

K Beinert, B Lutz, W Zieglgänsberger, M Diers
BACKGROUND: Visual analgesia refers to the phenomena where people report decreased pain intensity when they see the painful or painfully-stimulated body part. Alongside pain, sensorimotor impairment (i.e. disturbed proprioception) is also evident in chronic pain. This study aims to investigate whether real-time visual feedback offers additional pain relief and proprioceptive improvement when used in combination with recommended therapies in neck pain patients who received manual therapy with or without real-time visual feedback...
July 12, 2018: European Journal of Pain: EJP
Y M Costa, E N S de Araújo-Júnior, L Fiedler, P R S Jara, L L C P Silva, D M A O Ferreira, P C R Conti, L R Bonjardim
BACKGROUND: This study estimated the interrater reliability and agreement of the somatosensory assessment performed at masseter and temporomandibular joint (TMJ) region in a group of healthy female and male participants. METHODS: Forty healthy participants (20 men and 20 men) were evaluated in two sessions by two different examiners. Cold detection threshold (CDT), warm detection threshold (WDT), thermal sensory limen (TSL), cold pain threshold (CPT), heat pain threshold (HPT), mechanical detection threshold (MDT), mechanical pain threshold (MPT), wind-up ratio (WUR) and pressure pain threshold (PPT) were assessed on the skin overlying TMJ and masseter body...
July 10, 2018: European Journal of Pain: EJP
Yahyah Aman, Thomas Pitcher, Clive Ballard, Marzia Malcangio
BACKGROUND: Chronic pain conditions, especially osteoarthritis (OA), are as common in individuals with Alzheimer's disease (AD) as in the general elderly population, which results in detrimental impact on patient's quality of life. However, alteration in perception of pain in AD coupled with deteriorating ability to communicate pain sensations often result in under-diagnosis and inappropriate management of pain. Therefore, a better understanding of mechanisms in chronic pain processing in AD is needed...
July 10, 2018: European Journal of Pain: EJP
Lenko Saric, Katarina Vucic, Karmen Dragicevic, Marija Vrdoljak, Dora Jakus, Ivana Vuka, Antonia Jelicic Kadic, Ian J Saldanha, Livia Puljak
Conference abstracts are a potential source of new and relevant information about randomized controlled trials (RCTs). However, their dependability is questionable. The objectives of this study were to quantify the agreement between results of RCTs reported in abstracts presented at the four most recent World Congresses on Pain (WCP) and their corresponding full publications, and to analyze the completeness of reporting in those abstracts. To identify RCTs, we screened all abstracts presented at four WCPs from 2008 to 2014...
July 10, 2018: European Journal of Pain: EJP
L Morton, M de Bruin, M Krajewska, D Whibley, G J Macfarlane
BACKGROUND AND OBJECTIVE: Previous mass media campaigns have aimed to influence how people manage back pain, with mixed success. Campaigns should target beliefs which are related to the behaviours they aim to change. This systematic review brings together research that has measured the prevalence of beliefs about back pain in the general population and factors associated with these beliefs, including future pain-related outcomes. DATABASES AND DATA TREATMENT: Five databases were searched up until April 2017...
July 8, 2018: European Journal of Pain: EJP
K Bernardy, P Klose, P Welsch, W Häuser
BACKGROUND AND OBJECTIVE: This systematic review aimed at evaluating the efficacy, acceptability and safety of internet-based psychological therapies (IPTs) in fibromyalgia syndrome (FMS). DATABASES AND DATA TREATMENT: Cochrane Library, MEDLINE, PsycINFO and SCOPUS were searched from inception to January 2018. Randomized controlled trials (RCTs) comparing IPTs with controls were analysed. Primary outcomes were ≥ 50% pain relief, disability, negative mood, acceptability and safety at end of therapy and at six months follow up...
July 8, 2018: European Journal of Pain: EJP
J Loeser, J A Blunk, H Ruschulte, J Knitsch, M Karst, T Hucho
OBJECTIVES: Previously we found in cultures of primary neurons and in animals that sensitized primary neurons can be desensitized by treatment with e.g. beta-adrenergic receptor agonists. We now tested whether also in human sensitization such as UVB-radiation induced sunburn-like hyperalgesia can be reduced by intradermal injection of the beta-adrenergic receptor agonist terbutaline. METHODS: In our prospective randomized study seventeen participants received an individual UVB dose to cause a defined local sunburn-like erythema at four locations, two on each forearm...
July 8, 2018: European Journal of Pain: EJP
Christian Ziegeler, Kathrin Wasiljeff, Arne May
Patients with non-dental orofacial pain syndromes will often primarily consult general dentists and other dental specialists. Early and correct diagnosis and therapy is crucial to prevent chronification. We assessed the experience of dentists (general dentists and dental specialists) (n=533) and knowledge level of dental students (n=130) on the diagnosis and treatment of non-dental orofacial pain. We used an anonymized survey containing 14 items with the 4 main themes (i) prescription patterns, (ii) treatment strategies in non-dental orofacial pain, (iii) interdisciplinary cooperation and (iiii) self-assessment of knowledge as well as post-graduate education...
July 5, 2018: European Journal of Pain: EJP
Emily Foxen-Craft, Eric L Scott, Kristin A Kullgren, Reilly Philliben, Caroline Hyman, Marianna Dorta, Anne Murphy, Terri Voepel-Lewis
BACKGROUND: Pain location and widespread pain are important but underexamined dimensions of pediatric pain. Body map tools to assess pain location in youth have been used for several decades, but few studies have established reliability and validity of these measures. The purpose of this study was to explore the reliability and validity of a pain body map among youth with orthopedic conditions before surgery. METHOD: Youth ages 10-17 years completed the body map and other self-reported outcomes at their preoperative clinic visit and at their day of surgery...
July 5, 2018: European Journal of Pain: EJP
Anja Engelking, Marija Cavar, Livia Puljak
AIMS: New randomized clinical trials (RCTs) should be initiated if previous systematic reviews (SRs) indicate that new trials are needed. We analysed whether RCTs published in anesthesiology journals mentioned previous SRs as a rationale for conducting trial and for discussing results. METHODS: This was a meta-epidemiological, descriptive cross-sectional study. We analysed RCTs published in the seven first-quartile Anesthesiology journals between 2014 and 2016. We studied text and bibliography of the RCTs to assess whether the authors made a reference to previous SRs when justifying the need for their own clinical trial and discussing the results...
July 5, 2018: European Journal of Pain: EJP
Wen-Zhe Zhou, Tai-Yun Zhao, Zhi-Yuan Wang, Guan-Yi Lu, Shu-Zhuo Zhang, Cheng Zhang, Ning Wu, Jin Li
BACKGROUND: A combination of analgesic agents with different mechanisms can induce additive or synergistic analgesia. The N-type voltage-dependent calcium channel (N-VDCC) is a novel therapeutic target for pain control. In addition to providing effective pain relief when used alone, N-VDCC blockers produce synergistic analgesia when used in combination with opiates. However, the interaction between N-VDCC blockers and non-steroidal anti-inflammatory drugs (NSAIDs) remains unclear. METHODS: Using isobolographic analysis and composite additive curve analysis, the antinociceptive interaction between ZC88, a selective N-VDCC blocker, and ibuprofen, a classical NSAID, was investigated in two mouse models of visceral and somatic inflammatory pain...
July 5, 2018: European Journal of Pain: EJP
S A Amr, R M Reyad, A H Othman, M F Mohamad, M M Mostafa, N H Alieldin, F A Hamed
BACKGROUND: Radiofrequency ablation (RFA) of the splanchnic nerves has been reported as a predictable and safe technique for abdominal pain management. We compare between RFA and chemical neurolysis of bilateral thoracic splanchnic nerves in the management of refractory cancer pain. METHODS: The study was conducted on 60 patients aged ≥ 18 years who suffered from abdominal pain (visceral pain, VAS ≥ 4) due to upper abdominal cancers. Participants were randomised into two groups...
July 5, 2018: European Journal of Pain: EJP
M Ayranci, M Koutris, F Lobbezoo, P Svensson, L Baad-Hansen
BACKGROUND: Simple thermal devices providing reliable data are needed to detect somatosensory disturbances in non-specialized clinical settings. Currently, evidence is lacking about their use. Therefore, the aim was to compare the assessment of perceived thermal sensitivity/pain in healthy humans with a state-of-the-art thermotester and with simple inexpensive customized thermal aluminum devices. METHODS: Twenty healthy volunteers participated in the study. The infraorbital region and the tip of the tongue were tested with the Medoc Pathway thermotester and simple aluminium thermal devices, with temperatures varying between 5°C - 50°C...
June 29, 2018: European Journal of Pain: EJP
E Scala Emmanuelle, I Decosterd, M Faouzi, B Burnand, P-Y Rodondi
Given the limited alleviation of chronic pain with pharmacological treatments, various non-pharmacological and self-care approaches are often proposed, that require patients' motivation OBJECTIVE: Evaluation of the level of readiness (LOR) to practice different types of active self-care among chronic pain patients METHOD: A quantitative cross-sectional survey was conducted among all chronic pain patients seeking care at the Pain Center of an academic hospital from June 2013 to March 2015. Sociodemographic data, pain characteristics, treatments and the LOR to practice active self-care were investigated RESULTS: Among the 1524 eligible patients, 639 (41...
June 29, 2018: European Journal of Pain: EJP
Hiroki Nakata, Ryusuke Kakigi, Manabu Shibasaki
BACKGROUND: The present study investigated the characteristics of temperature-related evoked neural activities to baseline skin temperatures on target and adjacent sites using contact heat evoked potentials (CHEPs). METHODS: CHEPs were recorded from 12 normal subjects during three stimuli: target temperatures for Warm, Hot, and Pain were set to 41°C, 46°C, and 51°C, respectively. The baseline temperature was separately set at 30 °C, 35 °C, and 40 °C under all conditions, and a heat pulse was delivered over the right forearm at 41 °C under the Warm condition, at 46 °C under the Hot condition, and at 51 °C under the Pain condition RESULTS: The N2-P2 amplitude was significantly larger at the 40 °C baseline than at the 30 °C and 35 °C baselines during the Pain condition, whereas no significant differences were observed during the Hot and Warm conditions...
June 29, 2018: European Journal of Pain: EJP
M Hoegh, K K Petersen, T Graven-Nielsen
BACKGROUND: Conditioned pain modulation (CPM) may be impaired in chronic pain patients compared with healthy subjects. The CPM-effect is the difference between pain sensitivity assessments (test-stimuli) with and without a painful conditioning stimulus. CPM has been extensively explored but effects of repeated CPM-effects and differences between repeated CPM assessments and comparable control conditions are less studied. METHODS: In 20 healthy men, four 5-min bouts with a test-stimulus in the beginning and midway were applied by cuff-algometry to the dominant leg...
June 29, 2018: European Journal of Pain: EJP
Stefan Hakansson, Matthew D Jones, Michael Ristov, Lauren Marcos, Tomasin Clark, Adrian Ram, Rob Morey, Aysha Franklin, Chris McCarthy, Leal De Carli, Rachel Ward, Andrew Keech
PURPOSE: To investigate the chronic and acute effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on pressure pain thresholds (PPT) in overweight males. METHODS: Twenty-eight participants performed stationary cycling exercise 3 times per week for 6 weeks. Participants were randomly allocated to HIIT (10 × 1-minute intervals at 90% peak heart rate) or MICT (30 minutes at 65-75% peak heart rate). PPTs were assessed over the rectus femoris, tibialis anterior and upper trapezius before and after the 6-week training program (chronic effect) as well as before and after the first, middle and final exercise session (acute effect)...
June 29, 2018: European Journal of Pain: EJP
A Haehner, T Hummel, W Heinritz, S Krueger, M Meinhardt, K L Whitcroft, R Sabatowski, G Gossrau
Mutations in the sodium-channel Nav 1.7, encoded by the gene SCN9A, are known to cause pain disorders. In particular, gain-of-function missense mutations in Nav 1.7 have been shown to be causal in primary erythromelalgia. We present a patient with erythromelalgia, pain attacks and hyperosmia with a mutation within the sodium channel gene SCN9A. A 50-year-old woman presented with burning pain in both feet and abdominal pain attacks developed over the course of 10 years. Furthermore, this patient experienced a hypersensitivity for odors...
June 23, 2018: European Journal of Pain: EJP
Shota Oda, Masashi Izumi, Koji Aso, Masahiko Ikeuchi
BACKGROUND: Accumulating evidence indicates that knee pain gives rise to sensory and motor alterations, however, whether different profile of knee pain causes different alterations has not been investigated. The purpose of this experimental study is to clarify characteristics of medial and lateral knee pain and its potential for modulating sensory and motor function in humans. METHODS: Fourteen healthy men were included. Medial knee pain (MP) was induced by injection of hypertonic saline (0...
June 23, 2018: European Journal of Pain: EJP
Lance M McCracken, Shrina Patel, Whitney Scott
BACKGROUND: Suicidal thinking (ST) is common in people with chronic pain. It is relevant as it can be associated with suicidal attempts, and typically reflects significant suffering. While little is known about the psychological processes that contribute to ST, current psychological models, such as the Psychological Flexibility (PF) model, could help guide further investigation. This study investigates relations between ST and components of PF in chronic pain. METHODS: Participants were 424 adults attending treatment for chronic pain in the UK...
June 23, 2018: European Journal of Pain: EJP
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