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European Journal of Pain: EJP

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https://www.readbyqxmd.com/read/28055142/executive-functions-deficits-impair-extinction-of-generalization-of-fear-of-movement-related-pain
#1
N G Niederstrasser, A Meulders, M Meulders, D Struyf, J W Vlaeyen
BACKGROUND: Generalization of fear of movement-related pain across novel but similar movements can lead to fear responses to movements that are actually not associated with pain. The peak-shift effect describes a phenomenon whereby particular novel movements elicit even greater fear responses than the original pain-provoking movement (CS+), because they represent a more extreme version of the CS+. There is great variance in the propensity to generalize as well as the speed of extinction learning when these novel movements are not followed by pain...
January 5, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27977073/preoperative-sleep-quality-predicts-postoperative-pain-after-planned-caesarean-delivery
#2
S Orbach-Zinger, S Fireman, A Ben-Haroush, T Karoush, Z Klein, N Mazarib, A Artyukh, R Chen, A Ioscovich, L A Eidelman, R Landau
BACKGROUND: Severe post-caesarean pain remains an important issue associated with persistent pain and postpartum depression. Women's sleep quality prior to caesarean delivery and its influence on postoperative pain and analgesic intake have not been evaluated yet. METHODS: Women undergoing caesarean delivery with spinal anaesthesia (bupivacaine 12 mg, fentanyl 20 μg, morphine 100 μg) were evaluated preoperatively for sleep quality using the Pittsburgh Sleep Quality Index (PSQI) questionnaire (PSQI 0-5 indicating good sleep quality, PSQI 6-21 poor sleep quality)...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27977072/mechanical-pinprick-pain-in-patients-with-unilateral-spatial-neglect-the-influence-of-space-representation-on-the-perception-of-nociceptive-stimuli
#3
V Vizzari, S Barba, P Gindri, S Duca, D Giobbe, P Cerrato, G Geminiani, D M Torta
BACKGROUND: Crossing the hands over the midline can reduce the perceived intensity of nociceptive stimuli applied onto the hands. It remains unclear to what extent intact representation of peripersonal space influences this effect. Here we used the crossed-hands paradigm in patients with unilateral spatial neglect, a neuropsychological condition characterized by the inability to detect, attend and respond to contralesional (most often left) stimuli, and spared ability to process stimuli in the non-affected space...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27977070/role-of-transient-receptor-potential-ankyrin-1-receptors-in-rodent-models-of-meningeal-nociception-experiments-in%C3%A2-vitro
#4
A C Denner, B Vogler, K Messlinger, R De Col
BACKGROUND: The TRP channel ankyrin type 1 (TRPA1) is a nonselective cation channel known to be activated by environmental irritants, cold and endogenous mediators of inflammation. Activation of TRPA1 in trigeminal afferents innervating meningeal structures has recently been suggested to be involved in the generation of headaches. METHODS: Two in vitro models of meningeal nociception were employed using the hemisected rodent head preparation, (1) recording of single meningeal afferents and (2) release of calcitonin gene-related peptide (CGRP) from the cranial dura mater...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27977069/biological-mechanism-of-post-herpetic-neuralgia-evidence-from-multiple-patho-psychophysiological-measures
#5
W W Peng, X L Guo, Q Q Jin, H Wei, X L Xia, Y Zhang, P C Huang, W C Wang, S L Li, J S Wang, J Chen, L Hu
BACKGROUND: Post-herpetic neuralgia (PHN), which develops after the resolution of a herpes zoster eruption, is an exceptionally drug-resistant neuropathic pain. The unsatisfactory management of PHN partly results from the difficulty in dissecting out its contributing factors due to the complexity of PHN mechanism. METHODS: Here, to elaborate our understanding of the PHN mechanism and to establish a basis for effective therapeutic strategies, we comprehensively investigated the contributions of multiple factors to PHN severity...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27977068/development-of-a-repository-of-individual-participant-data-from-randomized-controlled-trials-of-therapists-delivered-interventions-for-low-back-pain
#6
S W Hee, M Dritsaki, A Willis, M Underwood, S Patel
BACKGROUND: Individual patient data (IPD) meta-analysis of existing randomized controlled trials (RCTs) is a promising approach to achieving sufficient statistical power to identify sub-groups. We created a repository of IPD from multiple low back pain (LBP) RCTs to facilitate a study of treatment moderators. Due to sparse heterogeneous data, the repository needed to be robust and flexible to accommodate millions of data points prior to any subsequent analysis. METHODS: We systematically identified RCTs of therapist delivered intervention for inclusion to the repository...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27891705/spinal-cord-stimulation-in-experimental-chronic-painful-diabetic-polyneuropathy-delayed-effect-of-high-frequency-stimulation
#7
M van Beek, M van Kleef, B Linderoth, S M J van Kuijk, W M Honig, E A Joosten
BACKGROUND: Spinal cord stimulation (SCS) has been shown to provide pain relief in painful diabetic polyneuropathy (PDPN). As the vasculature system plays a great role in the pathophysiology of PDPN, a potential beneficial side-effect of SCS is peripheral vasodilation, with high frequency (HF) SCS in particular. We hypothesize that HF-SCS (500 Hz), compared with conventional (CON) or low frequency (LF)-SCS will result in increased alleviation of mechanical hypersensitivity in chronic experimental PDPN...
November 28, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27891703/an-investigation-into-the-inhibitory-function-of-serotonin-in-diffuse-noxious-inhibitory-controls-in-the-neuropathic-rat
#8
K Bannister, S Lockwood, L Goncalves, R Patel, A H Dickenson
BACKGROUND: Following neuropathy α2-adrenoceptor-mediated diffuse noxious inhibitory controls (DNIC), whereby a noxious conditioning stimulus inhibits the activity of spinal wide dynamic range (WDR) neurons, are abolished, and spinal 5-HT7 receptor densities are increased. Here, we manipulate spinal 5-HT content in spinal nerve ligated (SNL) animals and investigate which 5-HT receptor mediated actions predominate. METHODS: Using in vivo electrophysiology we recorded WDR neuronal responses to von frey filaments applied to the hind paw before, and concurrent to, a noxious ear pinch (the conditioning stimulus) in isoflurane-anaesthetised rats...
November 28, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27862681/differences-in-analgesic-use-in-community-dwelling-persons-with-and-without-alzheimer-s-disease
#9
A Hamina, H Taipale, A Tanskanen, A-M Tolppanen, J Tiihonen, S Hartikainen
BACKGROUND: There are conflicting findings about analgesic use among persons with cognitive impairment compared to cognitively intact older persons. The objective of our study was to investigate the prevalence of analgesic use in community-dwelling persons with and without Alzheimer's disease (AD), within six months after AD diagnosis and to find out factors associated with the use of analgesics and specific analgesic groups. METHOD: We utilized data from register based MEDALZ (Medication use and Alzheimer's disease) cohort consisting of all community-dwelling persons diagnosed with AD during 2005-2011 in Finland and their matched comparison persons without AD...
November 14, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27862644/bilateral-experimental-neck-pain-reorganize-axioscapular-muscle-coordination-and-pain-sensitivity
#10
S W Christensen, R P Hirata, T Graven-Nielsen
BACKGROUND: Neck pain is a large clinical problem where reorganized trunk and axioscapular muscle activities have been hypothesised contributing to pain persistence and pain hypersensitivity. This study investigated the effects of bilateral experimental neck pain on trunk and axioscapular muscle function and pain sensitivity. METHODS: In 25 healthy volunteers, bilateral experimental neck pain was induced in the splenius capitis muscles by hypertonic saline injections...
November 11, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27859944/user-independent-assessment-of-conditioning-pain-modulation-by-cuff-pressure-algometry
#11
T Graven-Nielsen, M Izumi, K K Petersen, L Arendt-Nielsen
BACKGROUND: The use of conditioning pain modulation (CPM) is hampered by poor reproducibility and lack of user-independent paradigms. This study refined the CPM paradigm by applying user-independent cuff algometry. METHODS: In 20 subjects, the CPM effect of conditioning with cuff stimulation on the arm was investigated by pain test stimuli on the contralateral leg before and in parallel with different cuff conditionings (10, 30, 60 kPa/60 s; 30, 60 kPa/10 s)...
November 11, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27862616/topical-gabapentin-gel-alleviates-allodynia-and-hyperalgesia-in-the-chronic-sciatic-nerve-constriction-injury-neuropathic-pain-model
#12
M Shahid, F Subhan, N Ahmad, G Ali, S Akbar, K Fawad, R D E Sewell
BACKGROUND: Systemic gabapentin is a mainstay treatment for neuropathic pain though there are side-effects. Localized therapy may curtail such side-effects so a topical gabapentin dermal application was examined in the chronic constriction injury (CCI) model of neuropathic pain. METHODS: Partial denervation CCI was achieved by rat sciatic nerve ligation. Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days...
November 8, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27860026/medical-specialists-care-and-hospital-costs-for-low-back-pain-in-the-netherlands
#13
C J Itz, B L T Ramaekers, M van Kleef, C D Dirksen
BACKGROUND: To examine the organization of medical specialist care and hospital costs for low back pain (LBP) in the Netherlands. METHODS: Aggregated health insurance claims data were provided on all diagnosis treatment combination (DTC) declarations for LBP patients first referred to the hospital in the 2nd half of 2008 and retrieved from Vektis, an organization that collects health insurance claims data. Data were available up to 1 January 2012. The data included patient characteristics, DTC-specific information including: neurology, neurosurgery, orthopaedic surgery, anaesthesiology and radiology...
November 8, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27807916/alpha-range-visual-and-auditory-stimulation-reduces-the-perception-of-pain
#14
K Ecsy, A K P Jones, C A Brown
BACKGROUND: Alpha power is believed to have an inverse relationship with the perception of pain. Increasing alpha power through an external stimulus may, therefore, induce an analgesic effect. Here, we attempt to modulate the perception of a moderately painful acute laser stimulus by separately entraining three frequencies across the alpha band: 8, 10 and 12 Hz. METHODS: Participants were exposed to either visual or auditory stimulation at three frequencies in the alpha-band range and a control frequency...
November 2, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27805769/basal-ganglia-dysfunction-in-complex-regional-pain-syndrome-a-valid-hypothesis
#15
REVIEW
M Azqueta-Gavaldon, H Schulte-Göcking, C Storz, S Azad, A Reiners, D Borsook, L Becerra, E Kraft
: Complex regional pain syndrome (CRPS) is a poorly understood pain disorder of the limbs. Maladaptive cortical plasticity has been shown to play a major role in its pathophysiological presentation. Recently, there is increasing interest in the role of the basal ganglia (BG), since clinical findings and neuroimaging studies point to possible BG involvement in CRPS. CRPS symptoms are often characterized by movement disorders associated with BG dysfunction. Very frequently, dystonia and tremor are reported and, to a lesser extent, myoclonus...
November 2, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27805755/vendor-derived-differences-in-injury-induced-pain-phenotype-and-pharmacology-of-sprague-dawley-rats-does-it-matter
#16
P J Kristensen, A M Heegaard, S Hestehave, R D Jeggo, O J Bjerrum, G Munro
BACKGROUND: Outbred Sprague-Dawley (SD) rats are a commonly used strain in preclinical pain research. Here, we established empirically how SD rats obtained from different vendors might vary in sensitivity to injury and pharmacotherapy. METHODS: Chronic Constriction Injury (CCI) or complete Freund's adjuvant (CFA) hindpaw inflammation was induced in male SD rats sourced from three to four different vendors, respectively. Neuropathic hypersensitivity was evaluated over 58 days using von Frey filaments, pinprick stimulation and the hot plate test...
November 2, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27774680/threat-and-fear-of-pain-induces-attentional-bias-to-pain-words-an-eye-tracking-study
#17
L Sharpe, M Brookes, E Jones, C Gittins, E Wufong, M K Nicholas
BACKGROUND: This study aimed to investigate the effects of fear of pain (FOP) and threat on attentional biases, using eye-tracking methods. METHOD: One hundred and seven undergraduate students were randomized to receive threatening or reassuring information about the cold pressor task; and divided into high and low FOP groups. Participants completed the dot-probe task, while their eye movements were tracked. RESULTS: Results showed that those who received threatening information were less likely to have their first fixation on pain words, particularly affective pain words...
October 24, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28068006/comment-on-abdel-shaheed-et%C3%A2-al-efficacy-and-tolerability-of-muscle-relaxants-for-low-back-pain-systematic-review-and-meta-analysis
#18
LETTER
Sharanbasappa Durg
No abstract text is available yet for this article.
February 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28068005/authors-reply-to-the-comment-by-durg
#19
LETTER
C Abdel Shaheed, A J McLachlan, C G Maher
No abstract text is available yet for this article.
February 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27896907/efficacy-acceptability-and-safety-of-guided-imagery-hypnosis-in-fibromyalgia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
N Zech, E Hansen, K Bernardy, W Häuser
: This systematic review aimed at evaluating the efficacy, acceptability and safety of guided imagery/hypnosis (GI/H) in fibromyalgia. Cochrane Library, MEDLINE, PsycINFO and SCOPUS were screened through February 2016. Randomized controlled trials (RCTs) comparing GI/H with controls were analysed. Primary outcomes were ≥50% pain relief, ≥20% improvement of health-related quality of life, psychological distress, disability, acceptability and safety at end of therapy and 3-month follow-up...
February 2017: European Journal of Pain: EJP
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