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European Journal of Pain: EJP

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https://www.readbyqxmd.com/read/29336523/quadratus-lumborum-block-in-management-of-severe-pain-after-uterine-artery-embolization
#1
B Ben-David, Z Kaligozhin, D Viderman
BACKGROUND AND OBJECTIVES: The quadratus lumborum (QL) block has been widely used for acute postoperative pain management after numerous surgical procedures including urological, abdominal, gynaecological and orthopaedic surgical procedures. The local anaesthetic spread in this area can provide unilateral sensory block in T6-L2 dermatomes. We performed bilateral quadratus lumborum block for the management of acute pain after the uterine artery embolization (UAE). METHODS: A 43-year-old woman was admitted to the gynaecology department of Mother and Child Hospital, University Medical Center, for uterine artery embolization...
January 16, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29336514/machine-learned-analysis-of-quantitative-sensory-testing-responses-to-noxious-cold-stimulation-in-healthy-subjects
#2
I Weyer-Menkhoff, M C Thrun, J Lötsch
BACKGROUND: Pain in response to noxious cold has a complex molecular background probably involving several types of sensors. A recent observation has been the multimodal distribution of human cold pain thresholds. This study aimed at analysing reproducibility and stability of this observation and further exploration of data patterns supporting a complex background. METHOD: Pain thresholds to noxious cold stimuli (range 32-0 °C, tonic: temperature decrease -1 °C/s, phasic: temperature decrease -8 °C/s) were acquired in 148 healthy volunteers...
January 16, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29336505/signalling-transduction-events-involved-in-agonist-induced-pge2-ep4-receptor-externalization-in-cultured-rat-dorsal-root-ganglion-neurons
#3
W Ma, B St-Jacques
BACKGROUND: Prostaglandin E2 (PGE2) enriched in inflamed tissues contributes to chronic pain by sensitizing nociceptive dorsal root ganglion (DRG) neurons (nociceptors). Of four PGE2 receptors (EP1-4), EP4 plays a major role in PGE2-induced nociceptor sensitization. We have previously reported that PGE2 or EP4 agonists stimulated EP4 externalization in cultured DRG neurons and this event contributes to nociceptor sensitization. However, the signalling transduction events governing this event remain unknown...
January 16, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29282846/meta-analysis-of-transcutaneous-electrical-nerve-stimulation-for-relief-of-spinal-pain
#4
REVIEW
L Resende, E Merriwether, É P Rampazo, D Dailey, J Embree, J Deberg, R E Liebano, K A Sluka
We conducted a systematic review and meta-analysis analysing the existing data on transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) for chronic low back pain (CLBP) and/or neck pain (CNP) taking into account intensity and timing of stimulation, examining pain, function and disability. Seven electronic databases were searched for TENS or IFC treatment in non-specific CLBP or CNP. Four reviewers independently selected randomized controlled trials (RCTs) of TENS or IFC intervention in adult individuals with non-specific CLBP or CNP...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29282807/blocking-of-cytokines-signalling-attenuates-evoked-and-spontaneous-neuropathic-pain-behaviours-in-the-paclitaxel-rat-model-of-chemotherapy-induced-neuropathy
#5
S Al-Mazidi, M Alotaibi, T Nedjadi, A Chaudhary, M Alzoghaibi, L Djouhri
BACKGROUND: Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a serious dose-limiting neurotoxic effect of cancer drug treatment. The underlying mechanism(s) of this debilitating condition, which lacks effective drug treatment, is incompletely understood. However, neural-immune interactions, involving increased expression and release of cytokines, are believed to be involved. Here, we examined, in the paclitaxel rat model of CIPNP, whether plasma levels of 24 cytokines/chemokines change after paclitaxel treatment, and whether blocking of signalling of some of those cytokines would reverse/attenuate behavioural signs of CIPNP...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29280242/pain-patterns-during-adolescence-can-be-grouped-into-four-pain-classes-with-distinct-profiles-a-study-on-a-population-based-cohort-of-2953-adolescents
#6
S Holden, M S Rathleff, E M Roos, M B Jensen, N Pourbordbari, T Graven-Nielsen
INTRODUCTION: Although multi-site pain is common in adolescents, pain conditions are frequently diagnosed and treated in isolation. Little is known about whether there are specific sites in which pain commonly co-occurs. This study examines the patterns of pain in adolescents, and whether these are associated with sports participation, health-related quality of life (HRQoL), and sex. METHODS: In previously collected cohort data ('Adolescent Pain in Aalborg-2011'), adolescents (aged 12-19) completed an online questionnaire, including demographic data, current pain sites, sports participation and HRQoL (assessed by Euro-QoL 5D-3L)...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29280233/operant-self-administration-of-pregabalin-in-a-mouse-model-of-neuropathic-pain
#7
S A Bura, D Cabañero, R Maldonado
BACKGROUND: Pregabalin is a first-line agent for neuropathic pain treatment whose abuse liability remains controversial. Surprisingly, studies exploring the reinforcing properties of pregabalin in operant mouse models are missing. METHODS: We evaluated the acquisition of operant pregabalin self-administration in mice exposed to a partial sciatic nerve ligation (PSNL) or a sham operation. After surgery, mice were trained in operant boxes to intravenously self-administer pregabalin at 1...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29280231/a-biopsychosocial-understanding-of-lower-back-pain-content-analysis-of-online-information
#8
N M Black, S J Sullivan, R Mani
OBJECTIVES: (1) To develop a checklist to assess the representation of biopsychosocial lower back pain (LBP) online information; (2) to analyse publicly accessed online LBP information from a Google search for the degree that psychosocial contributors are described alongside the traditional biomedical approach to explaining LBP; (3) whether websites use information on pain biology to educate on LBP; (4) any inaccurate or false information regarding the mechanisms of LBP and; (5) the amount of websites certified by established benchmarks for quality health information...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29271541/pain-begets-pain-when-marathon-runners-are-not-in-pain-anymore-they-underestimate-their-memory-of-marathon-pain-a-mediation-analysis
#9
P Bąbel, E A Bajcar, M Śmieja, W Adamczyk, K Świder, P Kicman, N Lisińska
BACKGROUND: A previous study has shown that memory of pain induced by running a marathon might be underestimated. However, little is known about the factors that might influence such a memory distortion during pain recall. The aim of the study was to investigate the memory of pain induced by running a marathon and the factors that might influence it: (1) present pain during recall and (2) recall delay. METHODS: A total of 127 marathon runners participated in the study, which comprised of two phases...
December 22, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29271535/the-effect-of-visual-feedback-of-body-parts-on-pain-perception-a-systematic-review-of-clinical-and-experimental-studies
#10
REVIEW
P G Wittkopf, D M Lloyd, M I Johnson
The aim of this systematic review was to evaluate the effect of visual feedback techniques on pain perception by analysing the effect of normal-sized, magnified or minified visual feedback of body parts on clinical and experimentally-induced pain. Databases searched: Medline, Embase, PsychInfo, PEDro, CINAHL, CENTRAL and OpenSIGLE. Studies investigating pain patients and pain-free participants exposed to experimentally-induced pain were analysed separately. Risk of bias was assessed and data were meta-analysed...
December 22, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29266627/does-conditioned-pain-modulation-predict-the-magnitude-of-placebo-effects-in-patients-with-neuropathic-pain
#11
I Skyt, K Moslemi, C Baastrup, K Grosen, P Svensson, T S Jensen, L Vase
BACKGROUND: Conditioned pain modulation (CPM) is a validated measure of the function of endogenous pain inhibitory pathways. Placebo effects reflect top-down inhibitory modulation of pain. CPM and placebo effects are both influenced by expectations, albeit to varying degrees, and are related to neurotransmitter systems such as the endogenous opioid system, and it can be speculated that CPM responses are positively associated with the magnitude of placebo effects. Yet, no studies have tested this...
December 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29266544/expectations-about-the-effectiveness-of-pain-and-itch-relieving-medication-administered-via-different-routes
#12
K J Peerdeman, J Tekampe, A I M van Laarhoven, H van Middendorp, R C A Rippe, M L Peters, A W M Evers
BACKGROUND: Placebo effects on pain have been found to vary in size for different routes of medication administration (e.g. oral vs. injection). This has important implications for both clinical research and practice. To enhance our understanding of these differential placebo effects, research on the underlying expectations about multiple routes and symptoms other than pain is vital. METHODS: A cross-sectional, Internet-based survey was conducted in a representative sample of the Dutch population (n = 508)...
December 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29239055/brain-structural-alterations-associated-with-dysfunctional-cognitive-control-of-pain-in-patients-with-low-back-pain
#13
O Chehadi, A C Rusu, K Konietzny, E Schulz, O Köster, T Schmidt-Wilcke, M I Hasenbring
BACKGROUND: Recent evidence has shown that chronic back pain (CBP) can lead to functional alterations in the circuitry underlying the cognitive control of pain. Thought suppression (TS) is a common type of cognitive control of pain. Previous research has shown that TS has paradoxical effects that may increase the awareness of pain. Pain-related TS may also increase individuals' attention to pain, which may also increase pain sensation, but thus far, the relationship between pain-related TS and structural brain alterations is unknown...
December 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29235193/chronic-musculoskeletal-pain-in-european-older-adults-cross-national-and-gender-differences
#14
M Cimas, A Ayala, B Sanz, M S Agulló-Tomás, A Escobar, M J Forjaz
BACKGROUND: In an ageing Europe, chronic pain is a major public health problem, but robust epidemiological data are scarce. This study aimed to analyse the prevalence of and factors associated with chronic musculoskeletal pain by gender in older adults of 14 European countries. METHODS: A cross-sectional study was performed from wave 5 of the Survey of Health, Ageing and Retirement in Europe (SHARE). The study included people ≥50 years residing in Austria, Belgium, Czech Republic, Denmark, Estonia, France, Germany, Italy, Luxembourg, the Netherlands, Slovenia, Spain, Sweden and Switzerland...
December 12, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29226545/nitrous-oxide-oxygen-mixture-for-analgesia-in-adult-cancer-patients-with-breakthrough-pain-a-randomized-double-blind-controlled-trial
#15
Q Liu, L-L Gao, Y-L Dai, Y-X Li, Y Wang, C-F Bai, G-X Mu, X-M Chai, W-J Han, L-J Zhou, Y-J Zhang, L Tang, J Liu, J-Q Yu
BACKGROUND: The aim of this study was to assess the efficacy of a fixed nitrous oxide/oxygen mixture for the management of breakthrough cancer pain. METHODS/DESIGN: A double-blind, placebo-controlled, randomized clinical trial was undertaken in the Medical ward of Tumor Hospital of General Hospital of Ningxia Medical University. 240 cancer patients with breakthrough pain were recruited and randomly received a standard pain treatment (morphine sulphate immediate release) plus a pre-prepared nitrous oxide/oxygen mixture, or the standard pain treatment plus oxygen...
December 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29226500/anti-inflammatory-effects-of-propranolol-in-the-temporomandibular-joint-of-female-rats-and-its-contribution-to-antinociceptive-action
#16
F B Zanelatto, E V Dias, J M Teixeira, C R Sartori, C A Parada, C H Tambeli
BACKGROUND: β-Blockers reduce temporomandibular joint (TMJ) pain. We asked whether they also reduce TMJ inflammation and, if so, whether this anti-inflammatory effect contributes to its analgesic action. METHODS: We measured many parameters of the inflammatory response after co-administration of the β-blocker propranolol with the inflammatory agent carrageenan in the TMJ of female rats. We also hypothesized that the activation of β-adrenoceptors in the TMJ induces nociception mediated, at least in part, by the inflammatory response...
December 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29226495/forgetting-to-remember-prospective-memory-within-the-context-of-pain
#17
R Gatzounis, M G S Schrooten, G Crombez, J W S Vlaeyen
BACKGROUND: Pain interferes with cognitive functioning in several ways. Among other symptoms, pain patients often report difficulties with remembering future intentions. It remains unclear, however, whether it is the pain per se that impairs prospective remembering or other factors that often characterize people with pain (e.g. poor sleep quality). In this experiment, we investigated whether prospective memory is impaired within the context of pain, and whether this impairment is enhanced when the threat value of pain is increased...
December 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29214679/the-relationship-between-negative-metacognitive-thoughts-pain-catastrophizing-and-adjustment-to-chronic-pain
#18
M S Ziadni, J A Sturgeon, B D Darnall
BACKGROUND: Cognitive appraisals, most notably pain catastrophizing, play an important role in chronic pain. The role of metacognition and its impact on the relationship between pain catastrophizing and health are understudied. The identification of metacognition as a moderator of psychological constructs may have clinical and empirical implications. We hypothesized that negative metacognitive beliefs would moderate the relationships between pain catastrophizing and emotional functioning and physical activity...
December 7, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29194912/sharing-of-prescription-analgesics-amongst-patients-in-family-practice-frequency-and-associated-factors
#19
F Markotic, D Jurisic, M Curkovic, M Puljiz, M Novinscak, K Bonassin, D Vrdoljak, Z Vojvodic, S Permozer Hajdarovic, T Pekez-Pavlisko, M Tomicic, I Diminic-Lisica, S Fabris Ivsic, D Nejasmic, I Miosic, I Novak, L Puljak
OBJECTIVE: To analyse the frequency of nonrecreational prescription analgesic sharing, associated factors and differences between lenders and borrowers. METHODS: A cross-sectional study was conducted in 10 outpatient family medicine practices in Croatia amongst 1000 patients to whom their physicians have prescribed analgesics at least once in their lives. A questionnaire was used to collect data about patients' pain intensity, prescription analgesic sharing habits, factors associated with this behaviour, perception of risks associated with the conduct and demographic data...
December 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29194871/are-you-better-a-multi-centre-study-of-patient-defined-recovery-from-complex-regional-pain-syndrome
#20
A Llewellyn, C S McCabe, Y Hibberd, P White, L Davies, J Marinus, R G S M Perez, I Thomassen, F Brunner, C Sontheim, F Birklein, T Schlereth, A Goebel, R Haigh, R Connett, C Maihöfner, L Knudsen, R N Harden, A Zyluk, D Shulman, H Small, F Gobeil, P Moskovitz
BACKGROUND: Complex Regional Pain Syndrome (CRPS) symptoms can significantly differ between patients, fluctuate over time, disappear or persist. This leads to problems in defining recovery and in evaluating the efficacy of therapeutic interventions. OBJECTIVES: To define recovery from the patients' perspective and better understand their priorities for treatment approaches. METHODS: Establishing an international consortium, we used a 2-Round Delphi-based study in eight countries across Europe and North America...
December 1, 2017: European Journal of Pain: EJP
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