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European Journal of Pain: EJP

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https://www.readbyqxmd.com/read/29770535/ultrasound-guided-transversus-thoracic-plane-block-parasternal-block-and-fascial-planes-hydrodissection-for-internal-mammary-post-thoracotomy-pain-syndrome
#1
Emanuele Piraccini, Giulia Biondi, Helen Byrne, Morena Calli, Daniele Bellantonio, Giovanni Musetti, Stefano Maitan
INTRODUCTION: Pectoral Nerves Block (PECS) and Serratus Plane Block (SPB) have been used to treat persistent post-surgical pain after breast and thoracic surgery, however they cannot block the internal mammary region, so a residual pain may occur in that region. Parasternal block (PSB) and Thoracic Transversus Plane Block (TTP) anesthetize the anterior branches of T2-6 intercostal nerves thus they can provide analgesia to the internal mammary region. METHODS: We describe a 60-year-old man suffering from right post thoracotomy pain syndrome with residual pain located in the internal mammary region after a successful treatment with PECS and SPB We performed a PSB and TTP and hydrodissection of fascial planes with triamcinolone and Ropivacaine...
May 16, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29770520/quality-of-life-after-spinal-cord-injury-the-impact-of-pain
#2
D Burke, O Lennon, B M Fullen
BACKGROUND: Pain is a common complication after spinal cord injury (SCI). A mixture of nociceptive and neuropathic pain (NP) can present. Limited studies have investigated the impact of different pain phenotypes on quality of life (QoL) post-SCI. METHODS: Members registered to a national support group for those with SCIs were surveyed (n=1,574). The survey comprised questions relating to demographics and SCI characteristics, The Douleur Neuropathique 4 (DN4) (interview), the International SCI Pain Basic Data Set recording the worst pain and the World Health Organisation Quality of Life BREF (WHOQOL-BREF)...
May 16, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29758586/opioid-intake-prior-to-admission-is-not-increased-in-elderly-patients-with-low-energy-fractures-a-case-control-study-in-a-german-hospital-population
#3
A Schwarzer, M Kaisler, K Kipping, D Seybold, V Rausch, C Maier, J Vollert
BACKGROUND: Recent studies revealed an increased prescription rate of opioids for elderly patients suffering bone fractures. To gain further insight, we conducted face-to-face interviews in the present study to compare the opioid intake between patients with low energy fractures and patients suffering from internal diseases. METHODS: In this case-control study, 992 patients, aged 60 years and older, were enrolled between March 2014 and February 2015. The interview comprised a fall and medication history, comorbidities, mobility and other risk factors for fractures...
May 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29758584/inhibition-of-sympathetic-sprouting-in-ccd-rats-by-lacosamide
#4
Yuying Wang, Fuquan Huo
BACKGROUND: Early hyperexcitability activity of injured nerve/neuron is critical for developing sympathetic nerve sprouting within dorsal root ganglia (DRG). Since lacosamide (LCM), an anticonvulsant, inhibits Na+ channel. The present study tried to test the potential effect of LCM on inhibiting sympathetic sprouting in vivo. METHODS: LCM (50 mg/kg) was daily injected intraperitoneally into rats subjected to chronic compression DRG (CCD), an animal model of neuropathic pain that exhibits sympathetic nerve sprouting, for the 1st 7 days after injury...
May 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29756383/a-novel-affective-motivational-based-overground-system-for-detecting-spinal-cord-injury-associated-thermal-and-mechanical-hypersensitivity-in-rats
#5
Elizabeth A Dugan, Jacqueline Sagen
BACKGROUND: Preclinical research for neuropathic pain has depended primarily on the use of behavioral nociceptive testing that is sensory-discriminatory based and reflexive in nature. This can be particularly problematic in spinal cord injury (SCI) associated neuropathic pain research where hyperreflexia may develop thus confounding interpretation of reflexive responses as pain symptoms. To address this, we have designed an affective-motivational based Overground System that has interchangeable floors to allow examination of nociceptive behaviors in response to mechanical and cold stimuli prior to and following spinal cord injury...
May 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29756314/exploring-attentional-biases-towards-facial-expressions-of-pain-in-men-and-women
#6
E Keogh, F Cheng, S Wang
BACKGROUND: Interpersonal factors may help explain why men and women differ in their perception and expression of pain. Whilst the focus is often on the person in pain, how observers respond to those in pain is important. This study explored whether male-female differences exist in the way observers attend to expressions of pain in others. METHODS: 53 adults (26 females) completed a visual dot-probe task, to measure selective attentional biases to facial expressions of pain and fear...
May 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29756270/impact-of-suggestion-on-the-human-experimental-model-of-cold-hyperalgesia-after-topical-application-of-high-concentration-menthol-40
#7
Stephanie Helfert, Maren Reimer, Lutz Barnscheid, Philipp Hüllemann, Jens Rengelshausen, Thomas Keller, Ralf Baron, Andreas Binder
BACKGROUND: Human experimental pain models in healthy subjects offer unique possibilities to study mechanisms of pain within a defined setting of expected pain symptoms, signs and mechanisms. Previous trials in healthy subjects demonstrated that topical application of 40% menthol is suitable to induce cold hyperalgesia. The objective of this study was to evaluate the impact of suggestion on this experimental human pain model. METHODS: The study was performed within a single-center, randomized, placebo controlled, double-blind, 2 period cross-over trial in a cohort of 16 healthy subjects...
May 14, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29754439/exploring-psychological-mechanisms-of-clinical-response-to-an-internet-delivered-psychological-pain-management-program
#8
Milena Gandy, Eyal Karin, Michael Jones, Sarah McDonald, Louise Sharpe, Nick Titov, Blake Farran Dear
BACKGROUND: The evidence for Internet-delivered pain management programs for chronic pain is growing, but there is little empirical understanding of how they effect change. Understanding mechanisms of clinical response to these programs could inform their effective development and delivery. METHODS: A large sample (n = 396) from a previous randomised controlled trial of a validated internet-delivered psychological pain management program, the Pain Course, was used to examine the influence of three potential psychological mechanisms (pain acceptance, pain self-efficacy, fear of movement/re-injury) on treatment-related change in disability, depression, anxiety and average pain...
May 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29754428/tapering-off-long-term-opioid-therapy-in-chronic-non-cancer-pain-patients-a-randomized-clinical-trial
#9
Geana Paula Kurita, Jette Højsted, Per Sjøgren
BACKGROUND: The indications for initiating long-term opioid treatment (L-TOT) for chronic non-cancer pain (CNCP) are often unclear and associated with problematic use. This study aimed at evaluating the efficacy of stabilizing opioid therapy followed by a sequential opioid tapering off program in CNCP patients. METHODS: A randomized clinical trial with a medications stabilization period (Phase 1) followed by a opioid tapering off program (Phase 2). In Phase 2, patients were randomized to Control Group (stable treatment) or Taper off Group (sequential opioid dose reduction) and assessed at baseline, after stabilization and up to six months...
May 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29754420/the-predictive-value-of-the-heart-rate-variability-derived-analgesia-nociception-index-in-children-anaesthetised-with-sevoflurane-an-observational-pilot-study
#10
Frank Weber, Noortje J E Geerts, Hilde G Roeleveld, Annejet T Warmenhoven, Chantal A Liebrand
BACKGROUND: The heart rate variability (HRV) derived Analgesia Nociception Index (ANI™ ) is a continuous non-invasive tool to assess the nociception/anti-nociception balance in unconscious patients. It has been shown to be superior to hemodynamic variables in detecting insufficient anti-nociception in children, while little is known about its predictive value. METHODS: The primary objective of this prospective observational pilot study in paediatric surgical patients under sevoflurane anaesthesia, was to compare the predictive value of the ANI and heart rate to help decide to give additional opioids...
May 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29754398/development-and-course-of-chronic-pain-over-four-years-in-the-general-population-the-hunt-pain-study
#11
Tormod Landmark, Ola Dale, Pål Romundstad, Astrid Woodhouse, Stein Kaasa, Petter C Borchgrevink
BACKGROUND: Epidemiological studies of chronic pain frequently report high prevalence estimates. However, there is little information about the development and natural course of chronic pain. METHODS: We followed a random sample of participants from a population-based study (HUNT 3) with annual measures over four years. RESULTS: Among those without chronic pain at baseline, the probability of developing moderate to severe chronic pain (cumulative incidence) during the first year was 5%, a pain status that was maintained among 38% at the second follow-up...
May 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29704885/parental-chronic-widespread-pain-and-the-association-with-chronic-widespread-pain-in-adult-offspring-family-linkage-data-from-the-norwegian-hunt-study
#12
J R Zadro, T I L Nilsen, D Shirley, A B Amorim, P H Ferreira, P J Mork
BACKGROUND: Individuals experiencing chronic widespread pain (CWP) have greater disability and poorer quality-of-life compared to those with other chronic painful conditions; although research identifying risk factors for CWP is lacking. We aimed to investigate if parental CWP increases the risk of offspring CWP, and if offspring body mass index (BMI) and leisure-time physical activity modify this association. METHODS: We included 6,589 parent-offspring trios participating in the Norwegian HUNT Study in 1995-97 and 2006-08...
April 28, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29704880/feasibility-randomized-controlled-trial-of-online-acceptance-and-commitment-therapy-for-patients-with-complex-chronic-pain-in-the-united-kingdom
#13
W Scott, J Chilcot, B Guildford, A Daly-Eichenhardt, L M McCracken
BACKGROUND: Acceptance and Commitment Therapy (ACT) has growing support for chronic pain. However, more accessible treatment delivery is needed. This study evaluated the feasibility of online ACT for patients with complex chronic pain in the United Kingdom to determine whether a larger trial is justified. METHODS: Participants with chronic pain and clinically meaningful disability and distress were randomly assigned to ACT online plus specialty medical pain management, or specialty medical management alone...
April 28, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29704875/frequency-dependent-top-down-modulation-of-temporal-summation-by-anodal-transcranial-direct-current-stimulation-of-the-primary-motor-cortex-in-healthy-adults
#14
S Hughes, M Ali, P Sharma, N Insan, P H Strutton
BACKGROUND: Transcranial direct-current stimulation (tDCS) applied over the primary motor cortex has been shown to be effective in the treatment of a number of chronic pain conditions. However, there is a lack of understanding of the top-down analgesic mechanisms involved. METHOD: In this study, we investigated the effects of tDCS on the facilitation of subjective sensory and pain scores using a transcutaneous electrically-evoked measure of temporal summation. In this randomised, blinded, cross-over study healthy subjects received a single stimulus given at 0...
April 28, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29676840/behavioral-morphological-and-electrophysiological-assessment-of-the-effects-of-type-2-diabetes-mellitus-on-large-and-small-nerve-fibers-in-zucker-diabetic-fatty-rat-zucker-lean-and-wistar-rats
#15
E Garcia-Perez, T Schönberger, M Sumalla, B Stierstorfer, R Solà, H Doods, J Serra, N Gorodetskaya
BACKGROUND: Peripheral neuropathy is a common complication in type 2 diabetes mellitus (T2DM). The most common presentation is in the form of a distal axonal sensory-motor polyneuropathy that involves large and small nerve fibers in variable proportion. METHODS: Zucker Diabetic Fatty rats (ZDF), Zucker Lean (ZL) and Wistar Han (WH) rats were used to asses the behavioral, morphological and electrophysiological effects that T2DM have on peripheral large and small nerve fibers of 6-40 week-old rats...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29676839/analgesic-consumption-trajectories-in-8-975-patients-1-year-after-fast-track-total-hip-or-knee-arthroplasty
#16
C C Jørgensen, M Petersen, H Kehlet, E K Aasvang
BACKGROUND: Persistent or increased long-term opioid consumption has previously been described following total hip- (THA) and knee arthroplasty (TKA). However, detailed information on postoperative analgesic consumption trajectories and risk factors associated with continued need of analgesics in fast-track THA and TKA is sparse. METHODS: Descriptive multicenter study in primary unilateral fast-track THA or TKA with prospective data on patient characteristics and information on reimbursement entitled dispensed prescriptions of paracetamol, non-steroidal anti-inflammatory drugs, opioids, anticonvulsants, and antidepressants one month preoperatively and one year postoperatively...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29676837/twelve-year-follow-up-of-chronic-pain-in-twins-changes-in-environmental-and-genetic-influence-over-time
#17
A Burri, S Ogata, D Rice, F M K Williams
BACKGROUND: While genetic influences on chronic pain have been repeatedly demonstrated, we do not know whether these effects are stable or dynamic over time. AIMS: To determine the temporal pattern of genetic and environmental effects to individual differences in chronic pain over 12 years, we use a sample of n = 961 female twins. METHODS: Data on chronic pain were collected in 2004 (T1) and 2016 (T2) using the same comprehensive body map which divides the body into 31 distinct anatomical areas...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29676836/visually-induced-analgesia-in-a-deep-tissue-experimental-pain-model-a-randomised-cross-over-experiment
#18
M J van Selm, W I Gibson, M J Travers, G L Moseley, D Hince, B M Wand
BACKGROUND: Visualizing one's own painful body part appears to have an effect on reported pain intensity. Furthermore, it seems that manipulating the size of the viewed image can determine the direction and extent of this phenomenon. When visual distortion has been applied to clinical populations the analgesic effects have been in opposition to those observed in some experimental pain models. To help resolve this problem we explored the effect of visualisation and magnification of the visual image on reported pain using a delayed onset muscle soreness (DOMS) pain model...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29635880/avoiding-or-enduring-painful-sex
#19
L Engman, I K Flink, J Ekdahl, K Boersma, S J Linton
BACKGROUND: Recurring vulvovaginal pain is common, with evident effects on affected women's lives. Little is known about how affected women cope with painful sexual activities and how coping relates to pain intensity and psychosexual functioning over time. This prospective study explored the impact of avoidance and endurance on sexual function over time. Additionally, patterns of coping were studied on an individual level to increase knowledge about coping and its relation to psychosexual functioning...
April 10, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29635857/effect-profile-of-paracetamol-%C3%AE-9-thc-and-promethazine-using-an-evoked-pain-test-battery-in-healthy-subjects
#20
G van Amerongen, P Siebenga, M L de Kam, J L Hay, G J Groeneveld
BACKGROUND: A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and non-classic analgesics compared to a sedating negative control in a randomized placebo-controlled crossover study in 24 healthy volunteers using the PainCart...
April 10, 2018: European Journal of Pain: EJP
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