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European Journal of Pain: EJP

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https://www.readbyqxmd.com/read/28940720/diversity-in-the-emotional-modulation-of-pain-perception-an-account-of-individual-variability
#1
T A McIver, J Kornelsen, P W Stroman
BACKGROUND: While emotional state has been shown to modulate pain perception, there has been little consideration for the individual variability in this effect, or what factors may contribute to individual-level differences. The objective of this study was to characterize the variability in emotional modulation of pain in a healthy sample. METHODS: Twenty-five healthy, adult females participated in a heat pain-rating task. After calibration of the appropriate temperature for each participant, the pain-rating task was combined with viewing of positive, neutral, or negative valence images...
September 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28940665/prediction-of-persistent-post-operative-pain-pain-specific-psychological-variables-compared-with-acute-post-operative-pain-and-general-psychological-variables
#2
C Horn-Hofmann, J Scheel, V Dimova, A Parthum, R Carbon, N Griessinger, R Sittl, S Lautenbacher
BACKGROUND: Psychological variables and acute post-operative pain are of proven relevance for the prediction of persistent post-operative pain. We aimed at investigating whether pain-specific psychological variables like pain catastrophizing add to the predictive power of acute pain and more general psychological variables like depression. METHODS: In all, 104 young male patients undergoing thoracic surgery for pectus excavatum correction were studied on the pre-operative day (T0) and 1 week (T1) and 3 months (T2) after surgery...
September 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28913979/physical-pain-increases-interpersonal-trust-in-females
#3
C Wang, J Gao, Y Ma, C Zhu, X-W Dong
BACKGROUND: People behave and interact with others differently when experiencing physical pain. Pain has dramatic effects on one's emotional responses, cognitive functions and social interaction. However, little has been known about whether and how physical pain influences interpersonal trust in social interaction. In the present study, we examined the influence of physical pain on trusting behaviour. METHODS: A total of 112 healthy participants were recruited and assigned to physical pain condition (induced by Capsaicin) and control condition (with hand cream), respectively...
September 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28913854/preoperative-ultraviolet-b-inflammation-in-skin-modelling-individual-differences-in-acute-postoperative-pain-and-neuro-immune-interactions
#4
T H Lunn, J M Dawes, F Denk, D L Bennett, H Husted, H Kehlet, S B McMahon
BACKGROUND: Neuroimmune interactions play a vital role in many of the most common pain conditions, such as arthritis. There have been many attempts to derive clinically predictive information from an individual's inflammatory response in order to gauge subsequent pain perception. OBJECTIVES: Here, we wanted to test whether this effort could be enhanced and complemented by the use of a model system which takes into account the function of not just circulating, but also tissue-resident immune cells: ultraviolet B (UVB) irradiation of the skin...
September 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28898500/offset-analgesia-the-role-of-peripheral-and-central-mechanisms
#5
D Ligato, K K Petersen, C D Mørch, L Arendt-Nielsen
BACKGROUND: Offset Analgesia (OA) can be evoked by a three-heat-stimulus train (T1-T2-T3), with T1 (5 s) and T3 (20 s) having the same temperature (e.g. 48 °C) and T2 (5 s) being slightly higher (1-3 °C). OA is defined as a disproportional pain reduction caused by the slight temperature decrease from T2 to T3. As the pain modulatory mechanisms behind OA are still poorly understood, the current study aimed to investigate the role of peripheral and central mechanisms by applying heat stimuli to the same location and to different unilateral and bilateral locations...
September 12, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28898491/skin-denervation-does-not-alter-cortical-potentials-to-surface-concentric-electrode-stimulation-a-comparison-with-laser-evoked-potentials-and-contact-heat-evoked-potentials
#6
S La Cesa, G Di Stefano, C Leone, A Pepe, E Galosi, F Alu, A Fasolino, G Cruccu, M Valeriani, A Truini
BACKGROUND: In the neurophysiological assessment of patients with neuropathic pain, laser evoked potentials (LEPs), contact heat evoked potentials (CHEPs) and the evoked potentials by the intraepidermal electrical stimulation via concentric needle electrode are widely agreed as nociceptive specific responses; conversely, the nociceptive specificity of evoked potentials by surface concentric electrode (SE-PREPs) is still debated. METHODS: In this neurophysiological study we aimed at verifying the nociceptive specificity of SE-PREPs...
September 12, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28877402/effects-of-s-38093-an-antagonist-inverse-agonist-of-histamine-h3-receptors-in-models-of-neuropathic-pain-in-rats
#7
T Chaumette, E Chapuy, E Berrocoso, M Llorca-Torralba, L Bravo, J A Mico, M Chalus, A Eschalier, D Ardid, F Marchand, A Sors
BACKGROUND: Histamine H3 receptors are mainly expressed on CNS neurons, particularly along the nociceptive pathways. The potential involvement of these receptors in pain processing has been suggested using H3 receptor inverse agonists. METHODS: The antinociceptive effect of S 38093, a novel inverse agonist of H3 receptors, has been evaluated in several neuropathic pain models in rat and compared with those of gabapentin and pregabalin. RESULTS: While S 38093 did not change vocalization thresholds to paw pressure in healthy rats, it exhibited a significant antihyperalgesic effect in the Streptozocin-induced diabetic (STZ) neuropathy model after acute and chronic administration and, in the chronic constriction injury (CCI) model only after chronic administration, submitted to the paw-pressure test...
September 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28871611/long-term-trajectories-of-patients-with-neck-pain-and-low-back-pain-presenting-to-chiropractic-care-a-latent-class-growth-analysis
#8
L Ailliet, S M Rubinstein, T Hoekstra, M W van Tulder, H C W de Vet
BACKGROUND: Information on the course of neck pain (NP) and low back pain (LBP) typically relies on data collected at few time intervals during a period of up to 1 year. METHODS: In this prospective, multicentre practice-based cohort study, patients consulting a chiropractor responded weekly for 52 weeks to text messages on their cell phones. Data from 448 patients (153 NP, 295 LBP) who had returned at least one set of answers in the first 26 weeks were used...
September 4, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28869318/exercise-for-the-prevention-of-low-back-and-pelvic-girdle-pain-in-pregnancy-a-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
R Shiri, D Coggon, K Falah-Hassani
BACKGROUND AND OBJECTIVE: The effect of exercise in prevention of low back and pelvic girdle pain during pregnancy is uncertain. This study aimed to assess the effect of exercise on low back pain, pelvic girdle pain and associated sick leave. DATABASES AND DATA TREATMENT: Literature searches were conducted in PubMed, EMBASE, Cochrane Library, Google Scholar, ResearchGate and ClinicalTrials.gov databases from their inception through May 2017. Randomized controlled trials (RCTs) were eligible for inclusion in the review if they compared an exercise intervention with usual daily activities and at least some of the participants were free from low back pain and/or pelvic girdle pain at baseline...
September 4, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28845598/altered-pain-sensitivity-and-axioscapular-muscle-activity-in-neck-pain-patients-compared-with-healthy-controls
#10
S W Christensen, R P Hirata, T Graven-Nielsen
BACKGROUND: Previous studies have indicated that neck pain patients feel increased symptoms following upper limb activities, and altered axioscapular muscle function has been proposed as a contributing factor. METHODS: Pain sensitivity and muscle activity, during arm movements, were assessed in neck pain patients and controls. Patients with ongoing insidious-onset neck pain (IONP, N = 16) and whiplash-associated disorders (WAD, N = 9) were included along with sex- and age-matched controls (N = 25)...
August 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28845556/the-association-between-sleep-quality-low-back-pain-and-disability-a-prospective-study-in-routine-practice
#11
F M Kovacs, J Seco, A Royuela, J N Betegon, S Sánchez-Herráez, M Meli, M E Martínez Rodríguez, M Núñez, L Álvarez-Galovich, J Moyá, C Sánchez, S Luna, P Borrego, J Moix, V Rodríguez-Pérez, J Torres-Unda, N Burgos-Alonso, I Gago-Fernández, Y González-Rubio, V Abraira
BACKGROUND: The objective of this study was to estimate the association between sleep quality (SQ) and improvements in low back pain (LBP) and disability, among patients treated for LBP in routine practice. METHODS: This prospective cohort study included 461 subacute and chronic LBP patients treated in 11 specialized centres, 14 primary care centres and eight physical therapy practices across 12 Spanish regions. LBP, leg pain, disability, catastrophizing, depression and SQ were assessed through validated questionnaires upon recruitment and 3 months later...
August 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28833988/beyond-weakness-characterization-of-pain-sensory-profile-and-conditioned-pain-modulation-in-patients-with-motor-neuron-disease-a-controlled-study
#12
L C G Lopes, R Galhardoni, V Silva, F M H Jorge, L T Yeng, D Callegaro, G Chadi, M J Teixeira, D Ciampi de Andrade
BACKGROUND: Motor neuron diseases (MND) represent a group of disorders that evolve with inexorable muscle weakness and medical management is based on symptom control. However, deeper characterization of non-motor symptoms in these patients have been rarely reported. METHODS: This cross-sectional study aimed to describe non-motor symptoms in MND and their impact on quality of life and functional status, with a focus on pain and sensory changes. Eighty patients (31 females, 55...
August 22, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28815801/chronic-widespread-pain-prevalence-in-the-general-population-a-systematic-review
#13
REVIEW
P Andrews, M Steultjens, J Riskowski
Chronic widespread pain (CWP) is a significant burden in communities. Understanding the impact of population-dependent (e.g., age, gender) and contextual-dependent (e.g. survey method, region, inequality level) factors have on CWP prevalence may provide a foundation for population-based strategies to address CWP. Therefore, the purpose of this study was to estimate the global prevalence of CWP and evaluate the population and contextual factors associated with CWP. A systematic review of CWP prevalence studies (1990-2017) in the general population was undertaken...
August 17, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28809075/allosteric-modulation-of-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-desformylflustrabromine-potentiates-antiallodynic-response-of-nicotine-in-a-mouse-model-of-neuropathic-pain
#14
D Bagdas, D Ergun, A Jackson, W Toma, M K Schulte, M I Damaj
BACKGROUND: Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels. The α4β2 subtype of nAChRs plays an important role in the mediation of pain and several nicotine-evoked responses. Agonists and partial agonists of α4β2 nAChRs show efficacy in animal pain models. In addition, the antinociceptive properties of nicotine, a non-selective nAChR agonist with a high affinity for α4β2 nAChRs, is well-known. There is a growing body of evidence pointing to allosteric modulation of nAChRs as an alternative treatment strategy in experimental pain...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28805336/matrix-stimulation-in-cancer-pain-methodology-safety-and-effectiveness
#15
M Mücke, M Tils, R Conrad, D Kravchenko, H Cuhls, L Radbruch, M Marinova, V Peuckmann-Post, R Rolke
BACKGROUND: This feasibility study addresses the applicability of matrix electrodes for the reduction of ongoing pain in cancer patients via low-frequency electrical stimulation (LFS). METHODS: Low-frequency matrix stimulation (4 Hz) was applied to the skin within the 'Head's zones' referring to the tumour localization of cancer pain patients. Pain at baseline was compared to a 3-day treatment interval consisting of 5 min of matrix stimulation in the morning and evening followed by a 3-day follow-up period without therapy...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28805288/conditioned-pain-modulation-is-affected-by-occlusion-cuff-conditioning-stimulus-intensity-but-not-duration
#16
A Smith, A Pedler
BACKGROUND: Various conditioned pain modulation (CPM) methodologies have been used to investigate diffuse noxious inhibitory control pain mechanisms in healthy and clinical populations. Occlusion cuff parameters have been poorly studied. We aimed to investigate whether occlusion cuff intensity and/or duration influenced CPM magnitudes. We also investigated the role of physical activity levels on CPM magnitude. METHODS: Two studies were performed to investigate the role of intensity and duration of occlusion cuff conditioning stimulus on test stimulus (tibialis anterior pressure pain thresholds)...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28805281/efficacy-and-safety-of-a-fixed-dose-combination-of-ibuprofen-and-caffeine-in-the-management-of-moderate-to-severe-dental-pain-after-third-molar-extraction
#17
T Weiser, E Richter, A Hegewisch, D D Muse, R Lange
BACKGROUND: Ibuprofen is an effective analgesic treatment with a ceiling effect at doses above 400 mg. This study compared the combination of ibuprofen 400 mg and caffeine 100 mg with ibuprofen 400 mg monotherapy, caffeine and placebo in the analgesic treatment of moderate to severe acute dental pain following third molar extraction. METHODS: Phase III, active-/placebo-controlled, double-blind, single-centre, two-stage, parallel-group study in adult patients with at least moderate baseline pain intensity...
August 14, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28758313/altered-theta-oscillations-in-resting-eeg-of-fibromyalgia-syndrome-patients
#18
N Fallon, Y Chiu, T Nurmikko, A Stancak
BACKGROUND: Fibromyalgia syndrome (FM) is a chronic pain disorder characterized by widespread pain, sleep disturbance, fatigue and cognitive/affective symptoms. Functional imaging studies have revealed that FM and other chronic pain syndromes can affect resting brain activity. This study utilized electroencephalographic (EEG) recordings to investigate the relative power of ongoing oscillatory activity in the resting brain. METHODS: A 64-channel EEG was recorded at rest in 19 female FM patients and 18 healthy, age-matched, control subjects...
July 31, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28758312/testing-the-validity-of-telephone-interviews-to-assess-chronic-pain-in-children-and-adolescents-a-randomized-cross-over-trial
#19
J Wager, F Barth, L Stahlschmidt, B Zernikow
BACKGROUND: Telephone surveys are intended to reduce attrition in longitudinal studies. For paediatric chronic pain patients, the comparability of pain-related information gathered using telephone interviews and postal surveys remain unknown. Furthermore, it remains unknown how social desirability may influence answers. METHODS: To compare data from telephone interviews and postal surveys, a randomized cross-over design with two measure points 2 weeks apart and four conditions (combinations of telephone interviews (T) and postal surveys (P): P-T, T-P, P-P, T-T) was conducted in a sample of N = 323 paediatric chronic pain patients...
July 31, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28758311/was-it-less-painful-for-knights-influence-of-appearance-on-pain-perception
#20
A Weeth, A Mühlberger, Y Shiban
BACKGROUND: Pain perception is a subjective experience shaped by different factors. In this study, we investigated the influence of a visually manipulated appearance of a virtual arm on pain perception. Specifically, we investigated how pain perception and vegetative skin responses were modified by inducing a virtual protection on the right arm by a virtual armour. METHODS: Participants (n = 32) immersed in virtual reality embodied a virtual arm, which appeared in three different versions (uncovered, neutral or protected)...
July 31, 2017: European Journal of Pain: EJP
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