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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/28083691/personalized-medicine-a-new-option-for-nuclear-medicine-and-molecular-imaging-in-the-third-millennium
#1
EDITORIAL
Orazio Schillaci, Nicoletta Urbano
No abstract text is available yet for this article.
January 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28083690/the-68-ga-177-lu-theragnostic-concept-in-psma-targeting-of-castration-resistant-prostate-cancer-correlation-of-suvmax-values-and-absorbed-dose-estimates
#2
Lorenza Scarpa, Sabine Buxbaum, Dorota Kendler, Katharina Fink, Jasmin Bektic, Leonhard Gruber, Clemens Decristoforo, Christian Uprimny, Peter Lukas, Wolfgang Horninger, Irene Virgolini
INTRODUCTION: A targeted theragnostic approach based on increased expression of prostate-specific membrane antigen (PSMA) on PC cells is an attractive treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: Ten consecutive mCRPC patients were selected for (177)Lu-PSMA617 therapy on the basis of PSMA-targeted (68)Ga-PSMA-HBED-CC PET/CT diagnosis showing extensive and progressive tumour load. Following dosimetry along with the first therapy cycle restaging ((68)Ga-PSMA-HBED-CC and (18)F-NaF PET/CT) was performed after 2 and 3 therapy cycles (each 6...
January 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28083689/neural-correlates-of-the-popular-music-phenomenon-evidence-from-functional-mri-and-pet-imaging
#3
Qiaozhen Chen, Ying Zhang, Haifeng Hou, Fenglei Du, Shuang Wu, Lin Chen, Yehua Shen, Fangfang Chao, June-Key Chung, Hong Zhang, Mei Tian
PURPOSE: Music can induce different emotions. However, its neural mechanism remains unknown. The aim of this study was to use functional magnetic resonance imaging (fMRI) and position emission tomography (PET) imaging for mapping of neural changes under the most popular music in healthy volunteers. METHODS: Blood-oxygen-level-dependent (BOLD) fMRI and monoamine receptor PET imaging with (11)C-N-methylspiperone ((11)C-NMSP) were conducted under the popular music Gangnam Style and light music A Comme Amour in healthy subjects...
January 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28066877/central-noradrenaline-transporter-availability-in-highly-obese-non-depressed-individuals
#4
Swen Hesse, Georg-Alexander Becker, Michael Rullmann, Anke Bresch, Julia Luthardt, Mohammed K Hankir, Franziska Zientek, Georg Reißig, Marianne Patt, Katrin Arelin, Donald Lobsien, Ulrich Müller, S Baldofski, Philipp M Meyer, Matthias Blüher, Mathias Fasshauer, Wiebke K Fenske, Michael Stumvoll, Anja Hilbert, Yu-Shin Ding, Osama Sabri
PURPOSE: The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. METHODS: We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[(11)C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m(2)), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m(2)) healthy controls...
January 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28064344/diffuse-18-f-fdg-accumulation-in-the-subarachnoid-space-detected-by-pet-ct-in-a-patient-with-subarachnoid-hemorrhage-and-hyperglycemia
#5
Zhanli Fu, Jin Zhang, Meng Liu, Ziao Li, Qian Li
No abstract text is available yet for this article.
January 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28064343/quantitation-of-pet-signal-as-an-adjunct-to-visual-interpretation-of-florbetapir-imaging
#6
Michael J Pontecorvo, Anupa K Arora, Marybeth Devine, Ming Lu, Nick Galante, Andrew Siderowf, Catherine Devadanam, Abhinay D Joshi, Stephen L Heun, Brian F Teske, Stephen P Truocchio, Michael Krautkramer, Michael D Devous, Mark A Mintun
PURPOSE: This study examined the feasibility of using quantitation to augment interpretation of florbetapir PET amyloid imaging. METHODS: A total of 80 physician readers were trained on quantitation of florbetapir PET images and the principles for using quantitation to augment a visual read. On day 1, the readers completed a visual read of 96 scans (46 autopsy-verified and 50 from patients seeking a diagnosis). On day 2, 69 of the readers reinterpreted the 96 scans augmenting their interpretation with quantitation (VisQ method) using one of three commercial software packages...
January 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28062896/from-inflammation-to-calcification-in-atherosclerosis
#7
EDITORIAL
Takehiro Nakahara, H William Strauss
No abstract text is available yet for this article.
January 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28058463/erratum-to-role-of-pet-ct-in-malignant-pediatric-lymphoma
#8
Raef Riad, Walid Omar, Magdy Kotb, Magdy Hafez, Iman Sidhom, Manal Zamzam, Iman Zaky, Hussein Abdel-Dayem
No abstract text is available yet for this article.
January 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28058462/imaging-the-dna-damage-response-with-pet-and-spect
#9
REVIEW
James C Knight, Sofia Koustoulidou, Bart Cornelissen
DNA integrity is constantly challenged by endogenous and exogenous factors that can alter the DNA sequence, leading to mutagenesis, aberrant transcriptional activity, and cytotoxicity. Left unrepaired, damaged DNA can ultimately lead to the development of cancer. To overcome this threat, a series of complex mechanisms collectively known as the DNA damage response (DDR) are able to detect the various types of DNA damage that can occur and stimulate the appropriate repair process. Each DNA damage repair pathway leads to the recruitment, upregulation, or activation of specific proteins within the nucleus, which, in some cases, can represent attractive targets for molecular imaging...
January 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28058461/pet-brain-imaging-in-hiv-associated-neurocognitive-disorders-hand-in-the-era-of-combination-antiretroviral-therapy
#10
REVIEW
Jaime H Vera, Basil Ridha, Yvonne Gilleece, Aliza Amlani, Patrick Thorburn, Sabina Dizdarevic
Effective combination antiretroviral therapy (cART) has lead to a significant reduction in the prevalence and incidence of central nervous system (CNS) HIV-associated brain disease, particularly CNS opportunistic infections and HIV encephalitis. Despite this, cognitive deficits in people living with HIV, also known as HIV-associated neurocognitive disorders (HAND) have become more prevalent in recent years. The pathogenesis of HAND is likely to be multifactorial, however recent evidence suggests that brain microglial activation is the most likely pathogenic mechanism...
January 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28050631/head-to-head-comparison-between-18-f-fdopa-pet-ct-and-mr-ct-angiography-in-clinically-recurrent-head-and-neck-paragangliomas
#11
Céline Heimburger, Francis Veillon, David Taïeb, Bernard Goichot, Sophie Riehm, Julie Petit-Thomas, Gerlinde Averous, Marcela Cavalcanti, Fabrice Hubelé, Gerard Chabrier, Izzie Jacques Namer, Anne Charpiot, Alessio Imperiale
PURPOSE: Head and neck paragangliomas (HNPGLs) can relapse after primary treatment. Optimal imaging protocols have not yet been established for posttreatment evaluation. The aim of the present study was to assess the diagnostic value of (18)F-FDOPA PET/CT and MR/CT angiography (MRA/CTA) in HNPGL patients with clinical relapse during their follow-up. METHODS: Sixteen consecutive patients presenting with local pain, tinnitus, dysphagia, hoarse voice, cranial nerve involvement, deafness, or retrotympanic mass appearing during follow-up after the initial treatment of HNPGLs were retrospectively evaluated...
January 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28050630/myocardial-blood-flow-and-left-ventricular-functional-reserve-in-hypertrophic-cardiomyopathy-a-13-nh3-gated-pet-study
#12
Roberto Sciagrà, Raffaella Calabretta, Fabrizio Cipollini, Alessandro Passeri, Angelo Castello, Franco Cecchi, Iacopo Olivotto, Alberto Pupi
INTRODUCTION: Ischemia in hypertrophic cardiomyopathy (HCM) is caused by coronary microvascular dysfunction (CMD), which is detected by measuring myocardial blood flow (MBF) with PET. Whether CMD may be associated with ischemic left ventricular (LV) dysfunction is unclear. We therefore assessed LV ejection fraction (EF) reserve in HCM patients undergoing dipyridamole (Dip) PET. METHODS: Resting and stress (13)NH3 dynamic as well as gated PET were performed in 34 HCM patients...
January 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28039496/fdg-pet-imaging-to-detect-and-characterize-infectious-disorders-an-unavoidable-path-for-the-foreseeable-future
#13
EDITORIAL
Abass Alavi, Thomas J Werner
No abstract text is available yet for this article.
December 30, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28025656/a-systematic-review-of-lessons-learned-from-pet-molecular-imaging-research-in-atypical-parkinsonism-niccolini-and-politis-2016-reply-to-jean-claude-baron-letter-to-editor
#14
LETTER
Marios Politis
No abstract text is available yet for this article.
December 26, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28025655/targets-and-probes-for-non-invasive-imaging-of-%C3%AE-cells
#15
REVIEW
Andreas Jodal, Roger Schibli, Martin Béhé
β-cells, located in the islets of the pancreas, are responsible for production and secretion of insulin and play a crucial role in blood sugar regulation. Pathologic β-cells often cause serious medical conditions affecting blood glucose level, which severely impact life quality and are life-threatening if untreated. With 347 million patients, diabetes is one of the most prevalent diseases, and will continue to be one of the largest socioeconomic challenges in the future. The diagnosis still relies mainly on indirect methods like blood sugar measurements...
December 26, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28013350/textural-features-of-18-f-fluorodeoxyglucose-positron-emission-tomography-scanning-in-diagnosing-aortic-prosthetic-graft-infection
#16
Ben R Saleem, Roelof J Beukinga, Ronald Boellaard, Andor W J M Glaudemans, Michel M P J Reijnen, Clark J Zeebregts, Riemer H J A Slart
BACKGROUND: The clinical problem in suspected aortoiliac graft infection (AGI) is to obtain proof of infection. Although (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography scanning (PET) has been suggested to play a pivotal role, an evidence-based interpretation is lacking. The objective of this retrospective study was to examine the feasibility and utility of (18)F-FDG uptake heterogeneity characterized by textural features to diagnose AGI. METHODS: Thirty patients with a history of aortic graft reconstruction who underwent (18)F-FDG PET/CT scanning were included...
December 24, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28004135/nodal-parameters-of-fdg-pet-ct-performed-during-radiotherapy-for-locally-advanced-mucosal-primary-head-and-neck-squamous-cell-carcinoma-can-predict-treatment-outcomes-suvmean-and-response-rate-are-useful-imaging-biomarkers
#17
Peter Lin, Myo Min, Mark Lee, Lois Holloway, Dion Forstner, Victoria Bray, Allan Fowler
PURPOSE: To evaluate the prognostic utility of nodal metabolic parameters derived from FDG PET/CT performed before radiotherapy (prePET) and during the third week of radiotherapy (iPET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC). METHODS: This analysis included 75 patients with newly diagnosed locally advanced node-positive MPHNSCC treated with radical radiotherapy and concurrent systemic therapy who underwent prePET and iPET: N1 11 patients, N2a 38, N2b 12, N2c 9, N3 5...
December 21, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27999896/correlation-of-pretreatment-18-f-fdg-pet-tumor-textural-features-with-gene-expression-in-pharyngeal-cancer-and-implications-for-radiotherapy-based-treatment-outcomes
#18
Shang-Wen Chen, Wei-Chih Shen, Ying-Chun Lin, Rui-Yun Chen, Te-Chun Hsieh, Kuo-Yang Yen, Chia-Hung Kao
PURPOSE: This study investigated the correlation of the matrix heterogeneity of tumors on (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) with gene-expression profiling in patients with pharyngeal cancer and determined the prognostic factors for radiotherapy-based treatment outcomes. METHODS: We retrospectively reviewed the records of 57 patients with stage III-IV oropharyngeal or hypopharyngeal cancer who had completed definitive therapy...
December 20, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988802/local-recurrence-of-prostate-cancer-after-radical-prostatectomy-is-at-risk-to-be-missed-in-68-ga-psma-11-pet-of-pet-ct-and-pet-mri-comparison-with-mpmri-integrated-in-simultaneous-pet-mri
#19
Martin T Freitag, Jan P Radtke, Ali Afshar-Oromieh, Matthias C Roethke, Boris A Hadaschik, Martin Gleave, David Bonekamp, Klaus Kopka, Matthias Eder, Thorsten Heusser, Marc Kachelriess, Kathrin Wieczorek, Christos Sachpekidis, Paul Flechsig, Frederik Giesel, Markus Hohenfellner, Uwe Haberkorn, Heinz-Peter Schlemmer, A Dimitrakopoulou-Strauss
PURPOSE: The positron emission tomography (PET) tracer (68)Ga-PSMA-11, targeting the prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads to significant radioactivity in the bladder, which may limit the PET-detection of local recurrence (LR) of prostate cancer (PC) after radical prostatectomy (RP), developing in close proximity to the bladder. Here, we analyze if there is additional value of multi-parametric magnetic resonance imaging (mpMRI) compared to the (68)Ga-PSMA-11-PET-component of PET/CT or PET/MRI to detect LR...
December 17, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988801/measuring-the-actual-i-131-thyroid-uptake-curve-with-a-collar-detector-system-a-feasibility-study
#20
Peter Brinks, Koen Van Gils, Ellen Kranenborg, Jules Lavalaye, Dennis B M Dickerscheid, Jan B A Habraken
Radionuclide therapy using I-131 is commonly used for the treatment of benign thyroid diseases. The therapeutic dose to be administered is calculated based on the type of disease, the volume of the thyroid, and the measured uptake percentage. This methodology assumes a similar biological half-life of iodine, whereas in reality a large variation in biological half-life is observed. More knowledge about the actual biological half-life of iodine for individual patients will improve the quantification of the delivered radiation dose during radioiodine therapy and could aid the evaluation of the success of the therapy...
December 17, 2016: European Journal of Nuclear Medicine and Molecular Imaging
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