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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29687207/diagnostic-accuracy-of-bone-scintigraphy-in-the-assessment-of-cardiac-transthyretin-related-amyloidosis-a-bivariate-meta-analysis
#1
Giorgio Treglia, Andor W J M Glaudemans, Francesco Bertagna, Bouke P C Hazenberg, Paola A Erba, Raffaele Giubbini, Luca Ceriani, John O Prior, Luca Giovanella, Riemer H J A Slart
PURPOSE: Cardiac transthyretin-related amyloidosis (ATTR) is a progressive and fatal cardiomyopathy. The diagnosis of this disease is frequently delayed or missed due to the limited specificity of echocardiography. An increasing amount of data in the literature demonstrate the ability of bone scintigraphy with bone-seeking radiopharmaceuticals to detect myocardial amyloid deposits, in particular in patients with ATTR. Therefore we performed a systematic review and bivariate meta-analysis of the diagnostic accuracy of bone scintigraphy in patients with suspected cardiac ATTR...
April 23, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29687206/brain-fdg-pet-clinical-use-in-dementing-neurodegenerative-conditions
#2
EDITORIAL
Flavio Nobili, Reinhold Schmidt, Ignasi Carriò, Giovanni B Frisoni
No abstract text is available yet for this article.
April 23, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29680989/challenging-pre-surgical-localization-of-hyperfunctioning-parathyroid-glands-in-primary-hyperparathyroidism-the-added-value-of-18-f-fluorocholine-pet-ct
#3
Serena Grimaldi, Jacques Young, Peter Kamenicky, Dana Hartl, Marie Terroir, Sophie Leboulleux, Amandine Berdelou, Julien Hadoux, Segolene Hescot, Hervé Remy, Eric Baudin, Martin Schlumberger, Désirée Deandreis
PURPOSE: To evaluate the added value of 18 F-Fluorocholine (18 F-FCH) PET/CT in presurgical imaging of patients with primary hyperparathyroidism (HPT) and challenging localization of the hyper-functioning parathyroid glands. METHODS: We included 27 consecutive patients with primary HPT (19 F; median age: 58 years), with either (i) non-conclusive pre-surgical localization with 99 mTc-sestaMIBI scintigraphy and neck ultrasonography (US), (ii) recurrence of previously operated HPT, or (iii) familiar HPT with a suspicion of multiple gland disease...
April 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679113/increased-evidence-for-the-prognostic-value-of-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-in-irradiated-patients-with-oesophageal-carcinoma
#4
Yimin Li, Frank Hofheinz, Christian Furth, Chen Lili, Wu Hua, Pirus Ghadjar, Sebastian Zschaeck
PURPOSE: 18 F-FDG uptake in irradiated non-tumour-affected oesophagus (NTO) on restaging PET is a potential surrogate for the measurement of radiation-induced inflammation. Radiation-induced inflammation itself has been shown to be of high prognostic relevance in patients undergoing preoperative radiochemotherapy (RCT) for locally advanced oesophageal cancer. We assessed the prognostic relevance of FDG uptake in the NTO in an independent cohort of patients treated with definitive RCT...
April 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679112/post-treatment-positron-emission-tomography-computed-tomography-is-highly-predictive-of-outcome-in-plasmablastic-lymphoma
#5
Yassine Al Tabaa, Emmanuelle Tchernonog, Pierre Faurie, Anne Ségolène Cottereau, Hélène Monjanel, Antoine Bonnet, Steven Le Gouill, Emmanuel Gyan, Hervé Ghesquieres, Denis Mariano-Goulart, Guillaume Cartron
PURPOSE: Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B cell lymphomas (DLBCL) clinically characterized by a poorer prognostic. Few clinical and imaging data are available and derived from pooled case reports and small series. The aim of the study was to evaluate the FDG avidity at baseline and the utility of 18-Fluorodeoxyglucose (FDG) positron-emission-tomography/computed-tomography (PET/CT) for staging and response assessment. METHODS: Patients with newly diagnosed PBL seen at Lymphoma Study Association centers during the period 2005-2015 were included if they underwent a PET/CT at staging and at the end of treatment (eotPET) and had received an anthracycline-based first line therapy...
April 20, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679111/the-impact-of-a-bayesian-penalized-likelihood-reconstruction-algorithm-on-delayed-time-point-ga-68-psma-pet-for-improved-recurrent-prostate-cancer-detection
#6
Tiago Sampaio Vieira, Diogo Borges Faria, Fernando Azevedo Silva, Sérgio Barroso, Graça Fonseca, José Pereira Oliveira
No abstract text is available yet for this article.
April 20, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29671039/three-days-of-high-dose-glucocorticoid-treatment-attenuates-large-vessel-18f-fdg-uptake-in-large-vessel-giant-cell-arteritis-but-with-a-limited-impact-on-diagnostic-accuracy
#7
Berit Dalsgaard Nielsen, Lars Christian Gormsen, Ib Tønder Hansen, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge
PURPOSE: To evaluate the in-treatment diagnostic accuracy of FDG PET/CT in large-vessel giant cell arteritis (LV-GCA) by serial scans before and after a short course of high-dose glucocorticoid treatment. METHODS: Twenty-four glucocorticoid-naïve patients with new-onset PET/CT verified LV-GCA (pre-treatment baseline PET) were prospectively included. Excluded were patients with a previous history of GCA or polymyalgia rheumatica, LV-GCA-mimicking conditions and patients on immunosuppressive therapy...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29671038/-18-f-fdg-pet-and-high-resolution-mri-co-registration-for-pre-surgical-evaluation-of-patients-with-conventional-mri-negative-refractory-extra-temporal-lobe-epilepsy
#8
Yao Ding, Yuankai Zhu, Biao Jiang, Yongji Zhou, Bo Jin, Haifeng Hou, Shuang Wu, Junming Zhu, Zhong Irene Wang, Chong H Wong, Meiping Ding, Hong Zhang, Shuang Wang, Mei Tian
PURPOSE: Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography (18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes...
April 18, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29666891/should-we-assess-repeatability-of-pet-quantitative-uptake-measurements-of-each-18-f-labelled-tracer
#9
LETTER
Eric Laffon, Henri de Clermont, Sébastien Buj, Roger Marthan
No abstract text is available yet for this article.
April 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29663014/prediction-and-diagnosis-of-interval-metastasis-after-neoadjuvant-chemoradiotherapy-for-oesophageal-cancer-using-18-f-fdg-pet-ct
#10
Lucas Goense, Jelle P Ruurda, Brett W Carter, Penny Fang, Linus Ho, Gert J Meijer, Richard van Hillegersberg, Wayne L Hofstetter, Steven H Lin
OBJECTIVE: During neoadjuvant chemoradiotherapy for oesophageal cancer, or in the interval prior to surgery, some patients develop systemic metastasis. This study aimed to evaluate the diagnostic performance of 18 F-FDG PET/CT for the detection of interval metastasis and to identify predictors of interval metastases in a large cohort of oesophageal cancer patients. METHODS: In total, 783 consecutive patients with potentially resectable oesophageal cancer who underwent chemoradiotherapy and pre- and post-treatment 18 F-FDG PET/CT between 2006 and 2015 were analyzed from a prospectively maintained database...
April 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29654344/reply-should-we-assess-repeatability-of-pet-quantitative-uptake-measurements-of-each-18-f-labelled-tracer
#11
LETTER
G M Kramer, O S Hoekstra, R Boellaard
No abstract text is available yet for this article.
April 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29651546/is-there-an-optimal-method-for-measuring-baseline-metabolic-tumor-volume-in-diffuse-large-b-cell-lymphoma
#12
LETTER
Anne-Ségolène Cottereau, Irene Buvat, Salim Kanoun, Annibale Versari, Olivier Casasnovas, Stephane Chauvie, Jérôme Clerc, Andrea Gallamini, Michel Meignan
No abstract text is available yet for this article.
April 12, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29651545/extracardiac-18-f-florbetapir-imaging-in-patients-with-systemic-amyloidosis-more-than-hearts-and-minds
#13
T Wagner, J Page, M Burniston, A Skillen, J C Ross, R Manwani, D McCool, P N Hawkins, Ashutosh D Wechalekar
PURPOSE: 18 F-Florbetapir has been reported to show cardiac uptake in patients with systemic light-chain amyloidosis (AL). This study systematically assessed uptake of 18 F-florbetapir in patients with proven systemic amyloidosis at sites outside the heart. METHODS: Seventeen patients with proven cardiac amyloidosis underwent 18 F-florbetapir PET/CT imaging, 15 with AL and 2 with transthyretin amyloidosis (ATTR). Three patients had repeat scans. All patients had protocolized assessment at the UK National Amyloidosis Centre including imaging with 123 I-serum amyloid P component (SAP)...
April 12, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29644393/treatment-of-carcinoma-in-situ-of-the-urinary-bladder-with-an-alpha-emitter-immunoconjugate-targeting-the-epidermal-growth-factor-receptor-a-pilot-study
#14
Michael E Autenrieth, Christof Seidl, Frank Bruchertseifer, Thomas Horn, Florian Kurtz, Benedikt Feuerecker, Calogero D'Alessandria, Christian Pfob, Stephan Nekolla, Christos Apostolidis, Saed Mirzadeh, Jürgen E Gschwend, Markus Schwaiger, Klemens Scheidhauer, Alfred Morgenstern
PURPOSE: Patients with carcinoma in situ (CIS) of the bladder refractory to bacillus Calmette-Guérin (BCG) treatment are usually treated with cystectomy. Therefore, new treatment options with preservation of the urinary bladder are needed. The objective of the study was to investigate the feasibility, safety and efficacy of a novel targeted alpha-emitter immunotherapy for CIS after BCG treatment failure. METHODS: A pilot study was conducted in 12 patients (age range 64-86 years, ten men, two women) with biopsy-proven CIS of the bladder refractory to BCG treatment...
April 11, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29637252/fdg-pet-ct-a-imaging-in-large-vessel-vasculitis-and-polymyalgia-rheumatica-joint-procedural-recommendation-of-the-eanm-snmmi-and-the-pet-interest-group-pig-and-endorsed-by-the-asnc
#15
REVIEW
Riemer H J A Slart
Large vessel vasculitis (LVV) is defined as a disease mainly affecting the large arteries, with two major variants, Takayasu arteritis (TA) and giant cell arteritis (GCA). GCA often coexists with polymyalgia rheumatica (PMR) in the same patient, since both belong to the same disease spectrum. FDG-PET/CT is a functional imaging technique which is an established tool in oncology, and has also demonstrated a role in the field of inflammatory diseases. Functional FDG-PET combined with anatomical CT angiography, FDG-PET/CT(A), may be of synergistic value for optimal diagnosis, monitoring of disease activity, and evaluating damage progression in LVV...
April 11, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29627935/noradrenaline-transporter-availability-on-11-c-mrb-pet-predicts-weight-loss-success-in-highly-obese-adults
#16
Franziska J Vettermann, Michael Rullmann, Georg A Becker, Julia Luthardt, Franziska Zientek, Marianne Patt, Philipp M Meyer, Anke McLeod, Matthias Brendel, Matthias Blüher, Michael Stumvoll, Anja Hilbert, Yu-Shin Ding, Osama Sabri, Swen Hesse
PURPOSE: Although the mechanisms by which the central noradrenaline (NA) system influences appetite and controls energy balance are quite well understood, its relationship to changes in body weight remains largely unknown. The main goal of this study was to further clarify whether the brain NA system is a stable trait or whether it can be altered by dietary intervention. METHODS: We aimed to compare central NA transporter (NAT) availability in ten obese, otherwise healthy individuals with a body mass index (BMI) of 42...
April 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29623376/trifunctional-psma-targeting-constructs-for-prostate-cancer-with-unprecedented-localization-to-lncap-tumors
#17
James Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, David Schlyer, Yize Zhao, Dohyun Kim, John W Babich
PURPOSE: Treatment of late-stage prostate cancer by targeted radiotherapeutics such as131 I-MIP-1095 and177 Lu-PSMA-617 has shown encouraging early results. Lu-177 is preferred to I-131 in clinical settings, but targeted radioligand therapy (RLT) with177 Lu-PSMA-617 has not reached its full potential due to insufficient dose delivery to the tumor. We recently developed a dual-targeting radioiodinated ligand, RPS-027, that targets PSMA and uses albumin binding to enable good tumor uptake and significantly reduced kidney uptake in a preclinical model...
April 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29623375/ability-of-fdg-pet-and-ct-radiomics-features-to-differentiate-between-primary-and-metastatic-lung-lesions
#18
Margarita Kirienko, Luca Cozzi, Alexia Rossi, Emanuele Voulaz, Lidija Antunovic, Antonella Fogliata, Arturo Chiti, Martina Sollini
PURPOSE: To evaluate the ability of CT and PET radiomics features to classify lung lesions as primary or metastatic, and secondly to differentiate histological subtypes of primary lung cancers. METHODS: A cohort of 534 patients with lung lesions were retrospectively studied. Radiomics texture features were extracted using the LIFEx package from semiautomatically segmented PET and CT images. Histology data were recorded in all patients. The patient cohort was divided into a training and a validation group and linear discriminant analysis (LDA) was performed to classify the lesions using both direct and backward stepwise methods...
April 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29616304/tumor-metabolism-assessed-by-fdg-pet-ct-and-tumor-proliferation-assessed-by-genomic-grade-index-to-predict-response-to-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer
#19
David Groheux, L Biard, J Lehmann-Che, L Teixeira, F A Bouhidel, B Poirot, P Bertheau, P Merlet, M Espié, M Resche-Rigon, C Sotiriou, P de Cremoux
PURPOSE: Survival is increased when pathological complete response (pCR) is reached after neoadjuvant chemotherapy (NAC), especially in triple-negative breast cancer (TNBC) patients. Positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) and the genomic grade index (GGI), each separately, showed good potential to predict pCR. Our study was designed to evaluate the predictive value for the therapeutic response of a combination of parameters based on FDG-PET, histoclinical features and molecular markers of proliferation...
April 4, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29610956/prognostic-role-of-serial-quantitative-evaluation-of-18-f-fluorodeoxyglucose-uptake-by-pet-ct-in-patients-with-cardiac-sarcoidosis-presenting-with-ventricular-tachycardia
#20
Daniele Muser, Pasquale Santangeli, Simon A Castro, Jackson J Liang, Andres Enriquez, Thomas J Werner, Gaetano Nucifora, Silvia Magnani, Tatsuya Hayashi, Erica S Zado, Fermin C Garcia, David J Callans, Sanjay Dixit, Benoit Desjardins, Francis E Marchlinski, Abass Alavi
BACKGROUND: Positron emission tomography (PET) with18 F-fluorodeoxyglucose (FDG) has shown to be useful in diagnosis, staging and monitoring of cardiac sarcoidosis (CS) but its interpretation is not standardized. OBJECTIVES: We sought to investigate the clinical impact of serial quantitative FDG uptake analysis in patients with CS presenting with ventricular tachycardia (VT) treated by catheter ablation (CA). METHODS: We followed 20 patients (51 ± 9 years, 70% males) with CS and VT who underwent CA, with 92 serial FDG-PET scans (3-10 per patient)...
April 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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