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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/28634685/poor-predictive-value-of-positive-interim-fdg-pet-ct-in-primary-mediastinal-large-b-cell-lymphoma
#1
Julien Lazarovici, Marie Terroir, Julia Arfi-Rouche, Jean-Marie Michot, Sacha Mussot, Valentina Florea, Maria-Rosa Ghigna, Peggy Dartigues, Cynthia Petrovanu, Alina Danu, Christophe Fermé, Vincent Ribrag, David Ghez
PURPOSE: Though commonly used to assess response to therapy, the prognostic value of interim FDG-PET/CT in Primary Mediastinal Large B-cell Lymphoma (PMBCL) is unclear. METHODS: We conducted a retrospective study on 36 consecutive patients treated at our institution for a PMBCL between 2006 and 2014. All patients with a positive interim FDG-PET/CT had undergone histological restaging consisting either in a surgical debulking of the residual lesion (15 patients) or a CT-guided core needle biopsy (two patients)...
June 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28634684/heterogeneity-index-evaluated-by-slope-of-linear-regression-on-18-f-fdg-pet-ct-as-a-prognostic-marker-for-predicting-tumor-recurrence-in-pancreatic-ductal-adenocarcinoma
#2
Yong-Il Kim, Yong Joong Kim, Jin Chul Paeng, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
PURPOSE: (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been investigated as a method to predict pancreatic cancer recurrence after pancreatic surgery. We evaluated the recently introduced heterogeneity indices of (18)F-FDG PET/CT used for predicting pancreatic cancer recurrence after surgery and compared them with current clinicopathologic and (18)F-FDG PET/CT parameters. METHODS: A total of 93 pancreatic ductal adenocarcinoma patients (M:F = 60:33, mean age = 64...
June 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28634683/players-of-hypoxia-orchestra-what-is-the-role-of-fmiso
#3
EDITORIAL
Takuya Toyonaga, Kenji Hirata, Tohru Shiga, Tamaki Nagara
No abstract text is available yet for this article.
June 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28631036/practical-recommendations-for-radium-223-treatment-of-metastatic-castration-resistant-prostate-cancer
#4
Yong Du, Ignasi Carrio, Giuseppe De Vincentis, Stefano Fanti, Harun Ilhan, Caroline Mommsen, Egbert Nitzsche, Francis Sundram, Wouter Vogel, Wim Oyen, Val Lewington
PURPOSE: Radium Ra 223 dichloride (radium-223, Xofigo®) is the first targeted alpha therapy for patients with castration-resistant prostate cancer and symptomatic bone metastases. Radium-223 provides a new treatment option for this setting, but also necessitates a new treatment management approach. We provide straightforward and practical recommendations for European nuclear medicine centres to optimize radium-223 service provision. METHODS: An independent research consultancy agency observed radium-223 procedures and conducted interviews with all key staff members involved in radium-223 treatment delivery in 11 nuclear medicine centres across six countries (Germany, Italy, the Netherlands, Spain, Switzerland and the UK) experienced in administering radium-223...
June 19, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28624849/the-accuracy-of-68-ga-psma-pet-ct-in-primary-lymph-node-staging-in-high-risk-prostate-cancer
#5
Can Öbek, Tünkut Doğanca, Emre Demirci, Meltem Ocak, Ali Rıza Kural, Asıf Yıldırım, Uğur Yücetaş, Çetin Demirdağ, Sarper M Erdoğan, Levent Kabasakal
PURPOSE: To assess the diagnostic accuracy of (68)Ga-PSMA PET in predicting lymph node (LN) metastases in primary N staging in high-risk and very high-risk nonmetastatic prostate cancer in comparison with morphological imaging. METHODS: This was a multicentre trial of the Society of Urologic Oncology in Turkey in conjunction with the Nuclear Medicine Department of Cerrahpasa School of Medicine, Istanbul University. Patients were accrued from eight centres. Patients with high-risk and very high-risk disease scheduled to undergo surgical treatment with extended LN dissection between July 2014 and October 2015 were included...
June 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28624848/-177-lu-psma-617-radioligand-therapy-and-outcome-in-patients-with-metastasized-castration-resistant-prostate-cancer
#6
Axel Bräuer, Lena Sophie Grubert, Wolfgang Roll, Andres Jan Schrader, Michael Schäfers, Martin Bögemann, Kambiz Rahbar
PURPOSE: Radioligand therapies targeting prostate-specific membrane antigen (PSMA) have been established for the treatment of metastasized castration-resistant prostate cancer (mCRPC) in the last decade and show promising response rates and a favourable toxicity profile. The aim of this study was to evaluate the overall survival (OS) and to identify parameters predicting outcome in mCRPC patients treated with (177)Lu-PSMA-617. METHODS: Between December 2014 and January 2017, 59 consecutive patients (median age 72 years; interquartile range, (IQR, 66-76 years) with mCRPC, who had been treated with at least one next-generation antihormonal drug as well as chemotherapy, were included in this study...
June 17, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28623376/eanm-earl-harmonization-strategies-in-pet-quantification-from-daily-practice-to-multicentre-oncological-studies
#7
REVIEW
Nicolas Aide, Charline Lasnon, Patrick Veit-Haibach, Terez Sera, Bernhard Sattler, Ronald Boellaard
Quantitative positron emission tomography/computed tomography (PET/CT) can be used as diagnostic or prognostic tools (i.e. single measurement) or for therapy monitoring (i.e. longitudinal studies) in multicentre studies. Use of quantitative parameters, such as standardized uptake values (SUVs), metabolic active tumor volumes (MATVs) or total lesion glycolysis (TLG), in a multicenter setting requires that these parameters be comparable among patients and sites, regardless of the PET/CT system used. This review describes the motivations and the methodologies for quantitative PET/CT performance harmonization with emphasis on the EANM Research Ltd...
June 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28616695/prediction-of-breast-cancer-recurrence-using-lymph-node-metabolic-and-volumetric-parameters-from-18-f-fdg-pet-ct-in-operable-triple-negative-breast-cancer
#8
Yong-Il Kim, Yong Joong Kim, Jin Chul Paeng, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
PURPOSE: Triple-negative breast cancer has a poor prognosis. We evaluated several metabolic and volumetric parameters from preoperative (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the prognosis of triple-negative breast cancer and compared them with current clinicopathologic parameters. METHODS: A total of 228 patients with triple-negative breast cancer (mean age 47.0 ± 10.8 years, all women) who had undergone preoperative PET/CT were included...
June 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28612079/the-potential-of-223-ra-and-18-f-fluoride-imaging-to-predict-bone-lesion-response-to-treatment-with-223-ra-dichloride-in-castration-resistant-prostate-cancer
#9
Iain Murray, Sarah J Chittenden, Ana M Denis-Bacelar, Cecilia Hindorf, Christopher C Parker, Sue Chua, Glenn D Flux
PURPOSE: The aims of this study were to calculate bone lesion absorbed doses resulting from a weight-based administration of (223)Ra-dichloride, to assess the relationship between those doses and corresponding (18)F-fluoride uptake and to assess the potential of quantitative (18)F-fluoride imaging to predict response to treatment. METHODS: Five patients received two intravenous injections of (223)Ra-dichloride, 6 weeks apart, at 110 kBq/kg whole-body weight. The biodistribution of (223)Ra in metastatic lesions as a function of time after administration as well as associated lesion dosimetry were determined from serial (223)Ra scans...
June 13, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28612078/an-insight-into-the-eanm-technologist-committee-benchmark-document-on-nuclear-medicine-technologists-competencies
#10
Pedro Fragoso Costa, Andrea Santos, Giorgio Testanera
No abstract text is available yet for this article.
June 13, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28600647/hybrid-18-f-fdg-pet-mri-might-improve-locoregional-staging-of-breast-cancer-patients-prior-to-neoadjuvant-chemotherapy
#11
Briete Goorts, Stefan Vöö, Thiemo J A van Nijnatten, Loes F S Kooreman, Maaike de Boer, Kristien B M I Keymeulen, Romy Aarnoutse, Joachim E Wildberger, Felix M Mottaghy, Marc B I Lobbes, Marjolein L Smidt
PURPOSE: Our purpose in this study was to assess the added clinical value of hybrid (18)F-FDG-PET/MRI compared to conventional imaging for locoregional staging in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). METHODS: In this prospective study, primary invasive cT2-4 N0 or cT1-4 N+ breast cancer patients undergoing NAC were included. A PET/MRI breast protocol was performed before treatment. MR images were evaluated by a breast radiologist, blinded for PET images...
June 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28600646/increased-fdg-uptake-on-late-treatment-pet-in-non-tumour-affected-oesophagus-is-prognostic-for-pathological-complete-response-and-disease-recurrence-in-patients-undergoing-neoadjuvant-radiochemotherapy
#12
Sebastian Zschaeck, Frank Hofheinz, Klaus Zöphel, Rebecca Bütof, Christina Jentsch, Julia Schmollack, Steffen Löck, Jörg Kotzerke, Gustavo Baretton, Jürgen Weitz, Michael Baumann, Mechthild Krause
PURPOSE: Early side effects including oesophagitis are potential prognostic factors in patients undergoing radiochemotherapy (RCT) for locally advanced oesophageal cancer (LAEC). We assessed the prognostic value of (18)F-fluorodeoxyglucose (FDG) uptake within irradiated non-tumour-affected oesophagus (NTO) during restaging positron emission tomography (PET) as a surrogate for inflammation/oesophagitis. METHODS: This retrospective evaluation included 64 patients with LAEC who had completed neoadjuvant RCT and had successful oncological resection...
June 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28597120/long-term-prognostic-implications-of-myocardial-perfusion-imaging-in-octogenarians-an-all-comer-cohort-study
#13
Athanasios Katsikis, Athanasios Theodorakos, Vassiliki Manira, Spyridon Papaioannou, Genovefa Kolovou, Vassilios Voudris, Maria Koutelou
PURPOSE: Evaluation of the long-term prognostic value of myocardial perfusion imaging (MPI) in octogenarians. METHODS: Six hundred and twenty-nine octogenarians [51% previous myocardial infarction (MI) or revascularization] who underwent single-isotope MPI (78% (201)Tl, 22% (99m)Tc-tetrofosmin) with exercise (38% Bruce, 2% leg ergometry) or pharmacologic (58% adenosine, 2% dobutamine) stress were studied. All patients had LVEF determined by echocardiography within 1 month from MPI...
June 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28597119/highlights-lecture-eanm-2016-embracing-molecular-imaging-and-multi-modal-imaging-a-smart-move-for-nuclear-medicine-towards-personalized-medicine
#14
REVIEW
Eric O Aboagye, Françoise Kraeber-Bodéré
The 2016 EANM Congress took place in Barcelona, Spain, from 15 to 19 October under the leadership of Prof. Wim Oyen, chair of the EANM Scientific Committee. With more than 6,000 participants, this congress was the most important European event in nuclear medicine, bringing together a multidisciplinary community involved in the different fields of nuclear medicine. There were over 600 oral and 1,200 poster or e-Poster presentations with an overwhelming focus on development and application of imaging for personalized care, which is timely for the community...
June 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28593386/prostate-specific-membrane-antigen-pet-imaging-and-immunohistochemistry-in-adenoid-cystic-carcinoma-%C3%AF-a-preliminary-analysis
#15
Thomas J W Klein Nulent, Robert J J van Es, Gerard C Krijger, Remco de Bree, Stefan M Willems, Bart de Keizer
BACKGROUND: Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. A retrospective analysis of 9 AdCC patients was conducted to analyse the visualization of AdCC on PSMA PET/CT and to investigate the expression of PSMA on primary, recurrent and metastatic AdCC tumour tissue using immunohistochemistry...
June 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28589254/characterisation-of-malignant-peripheral-nerve-sheath-tumours-in-neurofibromatosis-1-using-heterogeneity-analysis-of-18-f-fdg-pet
#16
Gary J R Cook, Eitan Lovat, Muhammad Siddique, Vicky Goh, Rosalie Ferner, Victoria S Warbey
PURPOSE: Measurement of heterogeneity in (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) images is reported to improve tumour phenotyping and response assessment in a number of cancers. We aimed to determine whether measurements of (18)F-FDG heterogeneity could improve differentiation of benign symptomatic neurofibromas from malignant peripheral nerve sheath tumours (MPNSTs). METHODS: (18)F-FDG PET data from a cohort of 54 patients (24 female, 30 male, mean age 35...
June 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28589253/early-pet-imaging-with-68-ga-psma-11-increases-the-detection-rate-of-local-recurrence-in-prostate-cancer-patients-with-biochemical-recurrence
#17
Christian Uprimny, Alexander Stephan Kroiss, Josef Fritz, Clemens Decristoforo, Dorota Kendler, Elisabeth von Guggenberg, Bernhard Nilica, Johanna Maffey-Steffan, Gianpaolo di Santo, Jasmin Bektic, Wolfgang Horninger, Irene Johanna Virgolini
PURPOSE: PET/CT using (68)Ga-labelled prostate-specific membrane antigen PSMA-11 (HBEDD-CC) has emerged as a promising imaging method in the diagnostic evaluation of prostate cancer (PC) patients with biochemical recurrence. However, assessment of local recurrence (LR) may be limited by intense physiologic tracer accumulation in the urinary bladder on whole-body scans, normally conducted 60 min post-tracer injection (p.i.). It could be shown on early dynamic imaging studies that (68)Ga-PSMA-11 uptake in PC lesions occurs earlier than tracer accumulation in the urinary bladder...
June 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28584972/relation-between-thoracic-aortic-inflammation-and-features-of-plaque-vulnerability-in-the-coronary-tree-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-an-fdg-positron-emission-tomography-and-optical
#18
Nevio Taglieri, Cristina Nanni, Gabriele Ghetti, Rachele Bonfiglioli, Francesco Saia, Maria Letizia Bacchi Reggiani, Giacomo Maria Lima, Valeria Marco, Francesco Prati, Stefano Fanti, Claudio Rapezzi
PURPOSE: To evaluate the relationship between aortic inflammation as assessed by (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET) and features of plaque vulnerability as assessed by frequency domain-optical coherence tomography (FD-OCT). METHODS: We enrolled 30 consecutive non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. All patients underwent three-vessel OCT before intervention and (18)F-FDG-PET before discharge...
June 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28584971/f-18-fdg-and-f-18-tau-pet-in-posterior-cortical-atrophy
#19
Madhavi Tripathi, Abhinav Bansal, Vivek Baghel, Praveen Kumar, Chandrasekhar Bal
No abstract text is available yet for this article.
June 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28573331/fdg-pet-ct-for-systemic-staging-of-patients-with-newly-diagnosed-breast-cancer
#20
EDITORIAL
David Groheux
No abstract text is available yet for this article.
June 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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