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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/28233086/-18-f-fdg-pet-ct-predicts-survival-after-90-y-transarterial-radioembolization-in-unresectable-hepatocellular-carcinoma
#1
Mario Jreige, Periklis Mitsakis, Axel Van Der Gucht, Anastasia Pomoni, Marina Silva-Monteiro, Silvano Gnesin, Ariane Boubaker, Marie Nicod-Lalonde, Rafael Duran, John O Prior, Alban Denys, Niklaus Schaefer
PURPOSE: To compare the value of pretreatment functional and morphological imaging parameters for predicting survival in patients undergoing transarterial radioembolization using yttrium-90 ((90)Y-TARE) for unresectable hepatocellular carcinoma (uHCC). METHODS: We analysed data from 48 patients in our prospective database undergoing (90)Y-TARE treatment for uHCC (31 resin, 17 glass). All patients underwent (18)F-FDG PET/CT and morphological imaging (CT and MRI scans) as part of a pretherapeutic work-up...
February 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28229191/-18-f-fdg-pet-ct-imaging-versus-bone-marrow-biopsy-in-pediatric-hodgkin-s-lymphoma-a-quantitative-assessment-of-marrow-uptake-and-novel-insights-into-clinical-implications-of-marrow-involvement
#2
Aamna Hassan, Maimoona Siddique, Humayun Bashir, Saima Riaz, Rabia Wali, Asma Mahreen, M Khalid Nawaz
OBJECTIVE: To evaluate whether positron emission tomography/computed tomography using fluorine-18 fluoro-deoxyglucose ((18)F-FDG PET-CT) predicts bone marrow involvement (BMI) in pediatric Hodgkin's lymphoma (pHL) with sufficient accuracy to supplant routine staging bone marrow biopsy (BMB), and to assess the clinical importance of marrow disease by comparing the prognosis of stage IV HL with BMI versus that without BMI. METHODS: Data were retrospectively analyzed for all cases of pHL between July 2010 and June 2015 referred for staging (18)F-FDG PET-CT scan and BMB...
February 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28213773/radioiodine-treatment-after-surgery-for-differentiated-thyroid-cancer-a-reasonable-option
#3
EDITORIAL
Jérôme Clerc, Frederik A Verburg, Anca M Avram, Luca Giovanella, Elif Hindié, David Taïeb
No abstract text is available yet for this article.
February 17, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28210770/the-reset-button-revisited-why-high-activity-131-i-therapy-of-advanced-differentiated-thyroid-cancer-after-dosimetry-is-advantageous-for-patients
#4
EDITORIAL
Frederik A Verburg, Markus Luster, Luca Giovanella, Michael Lassmann, Carlo Chiesa, Nicolas Chouin, Glenn Flux
No abstract text is available yet for this article.
February 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28197686/pre-therapeutic-factors-for-predicting-survival-after-radioembolization-a-single-center-experience-in-389-patients
#5
K J Paprottka, F Schoeppe, M Ingrisch, J Rübenthaler, N N Sommer, E De Toni, H Ilhan, M Zacherl, A Todica, P M Paprottka
PURPOSE: To determine pre-therapeutic predictive factors for overall survival (OS) after yttrium (Y)-90 radioembolization (RE). METHODS: We retrospectively analyzed the pre-therapeutic characteristics (sex, age, tumor entity, hepatic tumor burden, extrahepatic disease [EHD] and liver function [with focus on bilirubin and cholinesterase level]) of 389 consecutive patients with various refractory liver-dominant tumors (hepatocellular carcinoma [HCC], cholangiocarcinoma [CCC], neuroendocrine tumor [NET], colorectal cancer [CRC] and metastatic breast cancer [MBC]), who received Y-90 radioembolization for predicting survival...
February 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28197685/test-retest-measurements-of-dopamine-d1-type-receptors-using-simultaneous-pet-mri-imaging
#6
Simon Kaller, Michael Rullmann, Marianne Patt, Georg-Alexander Becker, Julia Luthardt, Johanna Girbardt, Philipp M Meyer, Peter Werner, Henryk Barthel, Anke Bresch, Thomas H Fritz, Swen Hesse, Osama Sabri
PURPOSE: The role of dopamine D1-type receptor (D1R)-expressing neurons in the regulation of motivated behavior and reward prediction has not yet been fully established. As a prerequisite for future research assessing D1-mediated neuronal network regulation using simultaneous PET/MRI and D1R-selective [(11)C]SCH23390, this study investigated the stability of central D1R measurements between two independent PET/MRI sessions under baseline conditions. METHODS: Thirteen healthy volunteers (7 female, age 33 ± 13 yrs) underwent 90-min emission scans, each after 90-s bolus injection of 486 ± 16 MBq [(11)C]SCH23390, on two separate days within 2-4 weeks using a PET/MRI system...
February 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28190123/preclinical-imaging-characteristics-and-quantification-of-platinum-195m-spect
#7
E A Aalbersberg, B J de Wit-van der Veen, O Zwaagstra, K Codée-van der Schilden, E Vegt, Wouter V Vogel
AIMS: In vivo biodistribution imaging of platinum-based compounds may allow better patient selection for treatment with chemo(radio)therapy. Radiolabeling with Platinum-195m ((195m)Pt) allows SPECT imaging, without altering the chemical structure or biological activity of the compound. We have assessed the feasibility of (195m)Pt SPECT imaging in mice, with the aim to determine the image quality and accuracy of quantification for current preclinical imaging equipment. METHODS: Enriched (>96%) (194)Pt was irradiated in the High Flux Reactor (HFR) in Petten, The Netherlands (NRG)...
February 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28188325/correlation-between-tumour-characteristics-suv-measurements-metabolic-tumour-volume-tlg-and-textural-features-assessed-with-18-f-fdg-pet-in-a-large-cohort-of-oestrogen-receptor-positive-breast-cancer-patients
#8
Charles Lemarignier, Antoine Martineau, Luis Teixeira, Laetitia Vercellino, Marc Espié, Pascal Merlet, David Groheux
PURPOSE: The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (BC) patients, and 2) the capability of those parameters to predict response to neoadjuvant chemotherapy (NAC). METHODS: 171 consecutive patients with large or locally advanced ER+ BC without distant metastases underwent an (18)F-FDG PET examination before NAC...
February 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28184971/yes-we-can-analyse-amyloid-images-now-what
#9
EDITORIAL
Henryk Barthel, John Seibyl, Osama Sabri
No abstract text is available yet for this article.
February 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28180966/an-update-on-the-role-of-pet-ct-and-pet-mri-in-ovarian-cancer
#10
REVIEW
Benjapa Khiewvan, Drew A Torigian, Sahra Emamzadehfard, Koosha Paydary, Ali Salavati, Sina Houshmand, Thomas J Werner, Abass Alavi
This review article summarizes the role of PET/CT and PET/MRI in ovarian cancer. With regard to the diagnosis of ovarian cancer, the presence of FDG uptake within the ovary of a postmenopausal woman raises the concern for ovarian cancer. Multiple studies show that FDG PET/CT can detect lymph node and distant metastasis in ovarian cancer with high accuracy and may, therefore, alter the management to obtain better clinical outcomes. Although PET/CT staging is superior for N and M staging of ovarian cancer, its role is limited for T staging...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28180965/-18-f-fdg-pet-as-novel-imaging-biomarker-for-disease-progression-after-ablation-therapy-in-colorectal-liver-metastases
#11
M Samim, W Prevoo, B J de Wit-van der Veen, K F Kuhlmann, T Ruers, R van Hillegersberg, M A A J van den Bosch, H M Verkooijen, M G E H Lam, M P M Stokkel
PURPOSE: Recurrent disease following thermal ablation therapy is a frequently reported problem. Preoperative identification of patients with high risk of recurrent disease might enable individualized treatment based on patients' risk profile. The aim of the present work was to investigate the role of metabolic parameters derived from the pre-ablation (18)F-FDG PET/CT as imaging biomarkers for recurrent disease in patients with colorectal liver metastases (CLM). METHODS: Included in this retrospective study were all consecutive patients with CLM treated with percutaneous or open thermal ablation therapy who had a pre-treatment baseline (18)F-FDG PET/CT available...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28180964/radionuclide-imaging-of-subendocardial-ischaemia-an-insight-into-coronary-pathophysiology-or-a-technical-artefact
#12
EDITORIAL
Gianmario Sambuceti, Silvia Morbelli, Alessandro Bellini, Cecilia Marini
No abstract text is available yet for this article.
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28180963/-18-f-fdg-pet-reveals-unique-features-of-large-vessel-inflammation-in-patients-with-takayasu-s-arteritis
#13
Elena Incerti, Enrico Tombetti, Federico Fallanca, Elena M Baldissera, Pierpaolo Alongi, Elisabetta Tombolini, Silvia Sartorelli, Maria Grazia Sabbadini, Maurizio Papa, Francesco De Cobelli, Justin C Mason, Luigi Gianolli, Angelo A Manfredi, Maria Picchio
PURPOSE: The object of this study was to assess whether (18)F-fluorodeoxyglucose PET/CT (FDG PET/CT) provides novel information in patients with Takayasu's arteritis (TA) in addition to that provided by current activity assessment, to analyse the effects of possible confounders, such as arterial grafts, and to verify whether PET/CT could be informative in lesions <4 mm thick. METHODS: We studied 30 patients with TA, evaluated from October 2010 to April 2014 by both PET/CT and magnetic resonance imaging (MRI)...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28175934/investigating-the-role-of-spect-ct-in-dynamic-sentinel-lymph-node-biopsy-for-penile-cancers
#14
Ziauddin Zia Saad, Savvas Omorphos, Sofia Michopoulou, Svetislav Gacinovic, Peter Malone, Raj Nigam, Asif Muneer, Jamshed Bomanji
PURPOSE: Currently, most centres use 2-D planar lymphoscintigraphy when performing dynamic sentinel lymph node biopsy in penile cancer patients with clinically impalpable inguinal nodes. This study aimed to investigate the role of SPECT/CT following 2-D planar lymphoscintigraphy (dynamic and static) in the detection and localization of sentinel lymph nodes in the groin. METHODS: A qualitative (visual) review was performed on planar followed by SPECT/CT lymphoscintigraphy in 115 consecutive patients (age 28-86 years) who underwent injection of (99m)Tc-nanocolloid followed by immediate acquisition of dynamic (20 min) and early static scans (5 min) initially and further delayed static (5 min) images at 120 min followed by SPECT/CT imaging...
February 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28161723/-18-f-fdg-pet-mri-in-patients-suffering-from-lymphoma-how-much-mri-information-is-really-needed
#15
Julian Kirchner, Cornelius Deuschl, Johannes Grueneisen, Ken Herrmann, Michael Forsting, Philipp Heusch, Gerald Antoch, Lale Umutlu
OBJECTIVES: To evaluate and compare the diagnostic potential of different reading protocols, entailing non-enhanced/contrast-enhanced and diffusion-weighted (18)F-FDG PET/MR imaging for lesion detection and determination of the tumor stage in lymphoma patients. METHODS: A total of 101 (18)F-FDG PET/MRI datasets including a (1) transverse T2-w HASTE and (18)F-FDG PET (PET/MRI1), (2) with an additional contrast enhanced VIBE (PET/MRI2), and (3) with additional diffusion-weighted imaging (PET/MRI3) were evaluated...
February 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28154905/changes-in-dorsolateral-prefrontal-connectivity-after-rtms-in-treatment-resistant-depression-a-brain-perfusion-spect-study
#16
Raphaëlle Richieri, Damien Jouvenoz, Antoine Verger, Patrick Fiat, Laurent Boyer, Christophe Lançon, Eric Guedj
PURPOSE: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and safe alternative to electroconvulsive therapy for treatment-resistant depression (TRD). After rTMS, changes in brain SPECT perfusion have been remotely identified within medial temporal limbic areas, while no local effects have been found within the left dorsolateral prefrontal cortex (DLPFC)-i.e. under the coil. Functional changes in connectivity may underlie these remote effects. Interestingly, functional connectivity has been recently investigated using perfusion SPECT, and abnormalities identified in TRD patients...
February 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28154904/less-is-more-reconsidering-the-need-for-regular-use-of-diagnostic-whole-body-radioiodine-scintigraphy-in-the-follow-up-of-differentiated-thyroid-cancer
#17
EDITORIAL
Christian Pirich, Gregor Schweighofer-Zwink
No abstract text is available yet for this article.
February 2, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28138747/-68-ga-psma-11-pet-ct-in-primary-staging-of-prostate-cancer-psa-and-gleason-score-predict-the-intensity-of-tracer-accumulation-in-the-primary-tumour
#18
Christian Uprimny, Alexander Stephan Kroiss, Clemens Decristoforo, Josef Fritz, Elisabeth von Guggenberg, Dorota Kendler, Lorenza Scarpa, Gianpaolo di Santo, Llanos Geraldo Roig, Johanna Maffey-Steffan, Wolfgang Horninger, Irene Johanna Virgolini
PURPOSE: Prostate cancer (PC) cells typically show increased expression of prostate-specific membrane antigen (PSMA), which can be visualized by (68)Ga-PSMA-11 PET/CT. The aim of this study was to assess the intensity of (68)Ga-PSMA-11 uptake in the primary tumour and metastases in patients with biopsy-proven PC prior to therapy, and to determine whether a correlation exists between the primary tumour-related (68)Ga-PSMA-11 accumulation and the Gleason score (GS) or prostate-specific antigen (PSA) level...
January 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28138746/nuclear-medicine-training-and-practice-in-turkey
#19
Zehra Ozcan, M Fani Bozkurt, Belkıs Erbas, Hatice Durak
Nuclear medicine applications in Turkey started in the early 1950s, grew as an independent medical discipline and finally were recognized by the Ministry of Health in 1973. Later on, the professional organization of nuclear medicine physicians and other related professionals including radiopharmacists and technologists under the Turkish Society of Nuclear Medicine were established in 1975. Recently after completing more than a half century in Turkey, nuclear medicine has proved to be a strong and evolving medical field with more than 600 physicians serving for the changing needs of clinical practice throughout these years...
January 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28132110/the-added-value-of-spect-ct-for-the-identification-of-sentinel-lymph-nodes-in-early-stage-oral-cancer
#20
Inne J den Toom, Annelies van Schie, Stijn van Weert, K Hakki Karagozoglu, Elisabeth Bloemena, Otto S Hoekstra, Remco de Bree
PURPOSE: To assess the role of single-photon emission computed tomography with computed tomography (SPECT-CT) for the identification of sentinel lymph nodes (SLNs) in patients with early stage (T1-T2) oral cancer and a clinically negative neck (cN0). METHODS: In addition to planar lymphoscintigraphy, SPECT-CT was performed in 66 consecutive patients with early stage oral cancer and a clinically negative neck. The addition of SPECT-CT to planar images was retrospectively analyzed for the number of additional SLNs, more precise localization of SLNs, and importance of anatomical information by a team consisting of a nuclear physician, surgeon, and investigator...
January 29, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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