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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/30116837/propensity-score-analysis-of-18-fdg-pet-ct-enhanced-staging-in-patients-undergoing-surgery-for-esophageal-cancer
#1
N Patel, Kieran G Foley, A G Powell, J R Wheat, D Chan, P Fielding, S A Roberts, W G Lewis
PURPOSE: PET/CT is now integral to the staging pathway for potentially curable esophageal cancer (EC), primarily to identify distant metastases undetected by computed tomography. The aim of this study was to analyze the effect of PET/CT introduction on survival and assess patterns of recurrence after esophagectomy. METHODS: A longitudinal cohort of EC patients staged between 1998 and 2016 were considered for inclusion. After co-variate adjustment using propensity scoring, a cohort of 496 patients (273 pre-PET/CT and 223 post-PET/CT) who underwent esophagectomy [median age 63 years (31-80), 395 males, 425 adenocarcinomas, 71 squamous cell carcinomas, 325 neoadjuvant therapy] were included...
August 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30109402/differences-in-gray-and-white-matter-18-f-thk5351-uptake-between-behavioral-variant-frontotemporal-dementia-and-other-dementias
#2
Hye Joo Son, Jungsu S Oh, Jee Hoon Roh, Sang Won Seo, Minyoung Oh, Sang Ju Lee, Seung Jun Oh, Jae Seung Kim
PURPOSE: We investigated the regional distribution of 18 F-THK5351 uptake in gray (GM) and white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and compared it with that in patients with Alzheimer's disease (AD) or semantic dementia (SD). METHODS: 18 F-THK-5351 positron emission tomography (PET), 18 F-florbetaben PET, magnetic resonance imaging, and neuropsychological testing were performed in 103 subjects including 30, 24, 9, and 8 patients with mild cognitive impairment, AD, bvFTD, and SD, respectively, and 32 normal subjects...
August 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30109401/region-by-region-analysis-of-pet-mri-and-histology-in-en-bloc-resected-oligodendrogliomas-reveals-intra-tumoral-heterogeneity
#3
Kenney Roy Roodakker, Ali Alhuseinalkhudhur, Mohammed Al-Jaff, Maria Georganaki, Maria Zetterling, Shala G Berntsson, Torsten Danfors, Robin Strand, Per-Henrik Edqvist, Anna Dimberg, Elna-Marie Larsson, Anja Smits
PURPOSE: Oligodendrogliomas are heterogeneous tumors in terms of imaging appearance, and a deeper understanding of the histopathological tumor characteristics in correlation to imaging parameters is needed. We used PET-to-MRI-to-histology co-registration with the aim of studying intra-tumoral 11 C-methionine (MET) uptake in relation to tumor perfusion and the protein expression of histological cell markers in corresponding areas. METHODS: Consecutive histological sections of four tumors covering the entire en bloc-removed tumor were immunostained with antibodies against IDH1-mutated protein (tumor cells), Ki67 (proliferating cells), and CD34 (blood vessels)...
August 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30109400/delivering-pet-imaging-results-to-cancer-patients-steps-for-handling-ethical-issues
#4
LETTER
Sandra Gonzalez, Eric Guedj, Stefano Fanti, Elisabetta Lalumera, Pierre Le Coz, David Taïeb
No abstract text is available yet for this article.
August 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30105585/regulation-of-human-brown-adipose-tissue-by-adenosine-and-a-2a-receptors-studies-with-15-o-h-2-o-and-11-c-tmsx-pet-ct
#5
Minna Lahesmaa, Vesa Oikonen, Semi Helin, Pauliina Luoto, Mueez U Din, Alexander Pfeifer, Pirjo Nuutila, Kirsi A Virtanen
PURPOSE: Brown adipose tissue (BAT) has emerged as a potential target to combat obesity and diabetes, but novel strategies to activate BAT are needed. Adenosine and A2A receptor (A2AR) agonism activate BAT in rodents, and endogenous adenosine is released locally in BAT as a by-product of noradrenaline, but physiological data from humans is lacking. The purpose of this pilot study was to investigate the effects of exogenous adenosine on human BAT perfusion, and to determine the density of A2ARs in human BAT in vivo for the first time, using PET/CT imaging...
August 13, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30099578/-18-f-fdgpet-ct-in-fever-of-unknown-origin-and-inflammation-of-unknown-origin-a-chinese-multi-center-study
#6
Qian Wang, Ya-Ming Li, Yuan Li, Feng-Chun Hua, Quan-Shi Wang, Xiao-Li Zhang, Chao Cheng, Hua Wu, Zhi-Ming Yao, Wei-Fang Zhang, Qing-Yi Hou, Wei-Bing Miao, Xue-Mei Wang
PURPOSE: To evaluate the clinical value of 18 F-FDG-PET/CT for the diagnosis of fever of unknown origin (FUO) and inflammation of unknown origin (IUO) in Chinese population, as well as the characteristics of PET/CT in different category of etiological disease. METHODS: A total of 376 consecutive patients with FUO/IUO who underwent FDG-PET/CT at 12 hospitals were retrospectively studied. FDG uptake was quantitatively and visually evaluated, by using SUVmax and a 4-grade scale respectively...
August 11, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30099577/radiochemotherapy-induced-reactivation-of-scar-tissue-on-18-f-fdg-pet-ct
#7
Axel Van Damme, Fréderic Duprez, Peter Tomassen, David Creytens, Ingeborg Goethals
No abstract text is available yet for this article.
August 11, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30097670/influence-of-lanreotide-on-uptake-of-68-ga-dotatate-in-patients-with-neuroendocrine-tumours-a-prospective-intra-patient-evaluation
#8
E A Aalbersberg, B J de Wit-van der Veen, M W J Versleijen, L J Saveur, G D Valk, M E T Tesselaar, M P M Stokkel
INTRODUCTION: Somatostatin receptor imaging with PET is the standard of care for patients with a neuroendocrine tumour (NET). Since therapy and imaging with somatostatin analogues utilize the same receptor, current guidelines recommend withdrawing long-acting somatostatin analogues for 3-4 weeks prior to somatostatin receptor PET imaging. The aim of this study is to prospectively assess the effect of lanreotide use on the uptake of 68 Ga-DOTATATE intra-individually 1 day prior to and 1 day post injection of lanreotide...
August 10, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30094462/amyloid-imaging-for-differential-diagnosis-of-dementia-incremental-value-compared-to-clinical-diagnosis-and-18-f-fdg-pet
#9
Sabine Hellwig, Lars Frings, Tobias Bormann, Werner Vach, Ralph Buchert, Philipp T Meyer
PURPOSE: Cerebral beta-amyloid and regional glucose metabolism assessed by positron emission tomography (PET) are used as diagnostic biomarkers for Alzheimer's disease (AD). The present study validates the incremental diagnostic value of amyloid PET in addition to clinical diagnosis and [18 F]FDG PET in a real-life memory clinic population. METHODS: Of 138 consecutive patients with cognitive impairment who received combined [18 F]FDG and [11 C]PIB PET, 84 were diagnosed with major neurocognitive disorder (DSM-5) and included...
August 10, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30094461/diagnostic-performance-of-choline-pet-for-detection-of-hyperfunctioning-parathyroid-glands-in-hyperparathyroidism-a-systematic-review-and-meta-analysis
#10
Giorgio Treglia, Arnoldo Piccardo, Alessio Imperiale, Klaus Strobel, Philipp A Kaufmann, John O Prior, Luca Giovanella
PURPOSE: Hyperparathyroidism (HPT) is a common endocrine disorder caused by hyperfunctioning parathyroid glands (HP). The correct detection and localization of HP is challenging but crucial, as it may guide surgical treatment, particularly in patients with primary HPT. There is a growing body of data regarding the role of radiolabelled choline positron emission tomography (PET) in this setting. Therefore, we performed a systematic review and meta-analysis of the diagnostic performance of this method in detecting HP in patients with HPT...
August 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30094460/radiomics-analysis-of-pre-treatment-18-f-fdg-pet-ct-for-patients-with-metastatic-colorectal-cancer-undergoing-palliative-systemic-treatment
#11
E J van Helden, Y J L Vacher, W N van Wieringen, F H P van Velden, H M W Verheul, O S Hoekstra, R Boellaard, C W Menke-van der Houven van Oordt
BACKGROUND: The aim of this study was to assess radiomics features on pre-treatment [18 F]FDG positron emission tomography (PET) as potential biomarkers for response and survival in patients with metastatic colorectal cancer (mCRC). METHODS: Patients with mCRC underwent [18 F]FDG PET/computed tomography (CT) prior to first- or third-line palliative systemic treatment. Tumour lesions were semiautomatically delineated and standard uptake value (SUV), metabolically active tumour volume (MATV), total lesion glycolysis (TLG), entropy, area under the curve of the cumulative SUV-volume histogram (AUC-CSH), compactness and sphericity were obtained...
August 9, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30090966/disease-related-patterns-of-in-vivo-pathology-in-corticobasal-syndrome
#12
Flavia Niccolini, Heather Wilson, Stephanie Hirschbichler, Tayyabah Yousaf, Gennaro Pagano, Alexander Whittington, Silvia P Caminiti, Roberto Erro, Janice L Holton, Zane Jaunmuktane, Marcello Esposito, Davide Martino, Ali Abdul, Jan Passchier, Eugenii A Rabiner, Roger N Gunn, Kailash P Bhatia, Marios Politis
PURPOSE: To assess disease-related patterns of in vivo pathology in 11 patients with Corticobasal Syndrome (CBS) compared to 20 healthy controls and 33 mild cognitive impairment (MCI) patients due to Alzheimer's disease. METHODS: We assessed tau aggregates with [18 F]AV1451 PET, amyloid-β depositions with [18 F]AV45 PET, and volumetric microstructural changes with MRI. We validated for [18 F]AV1451 standardised uptake value ratio (SUVRs) against input functions from arterial metabolites and found that SUVRs and arterial-derived distribution volume ratio (DVRs) provide equally robust measures of [18 F]AV1451 binding...
August 8, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30090965/first-in-human-study-of-177-lu-eb-psma-617-in-patients-with-metastatic-castration-resistant-prostate-cancer
#13
Jie Zang, Xinrong Fan, Hao Wang, Qingxing Liu, Jingnan Wang, Hui Li, Fang Li, Orit Jacobson, Gang Niu, Zhaohui Zhu, Xiaoyuan Chen
PURPOSE: This translational study is designed to assess the safety, dosimetry and therapeutic response to a single, low-dose of 177 Lu-EB-PSMA-617 in comparison to 177 Lu-PSMA-617 in patients with mCRPC. METHODS: Following institutional review board approval and informed consent, nine patients with mCRPC were recruited. Four patients accepted intravenous injection of 0.80-1.1 GBq (21.5-30 mCi) of 177 Lu-EB-PSMA-617, then underwent serial whole-body planar and SPECT/CT imaging at 2, 24, 72, 120 and 168 h...
August 8, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30083825/-90-y-radioembolization-of-hepatocellular-carcinoma-from-a-theranostic-perspective-towards-a-personalized-approach
#14
LETTER
Luca Filippi, Orazio Schillaci, Oreste Bagni
No abstract text is available yet for this article.
August 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30083824/outcome-of-patients-with-early-stage-follicular-lymphoma-staged-with-18-f-fluorodeoxyglucose-fdg-positron-emission-tomography-pet-and-treated-with-radiotherapy-alone
#15
Sweet Ping Ng, Richard Khor, Mathias Bressel, Michael MacManus, John F Seymour, Rodney J Hicks, Andrew Wirth
PURPOSE/OBJECTIVE(S): To evaluate the impact of positron emission tomography (PET) staging on overall survival (OS) and progression-free survival (PFS) in patients with early-stage (stages I and II) follicular lymphoma (ESFL) treated with radiation therapy alone. MATERIALS/METHODS: Eighty-five patients with ESFL treated with curative-intent radiation therapy (RT) between December 2000 and May 2011 were identified. Of those, 13 who had no PET staging and 25 who received additional systemic therapy were excluded from the analysis...
August 7, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30074073/prospective-comparison-of-18-f-fdg-pet-mri-and-18-f-fdg-pet-ct-for-thoracic-staging-of-non-small-cell-lung-cancer
#16
Julian Kirchner, Lino M Sawicki, Felix Nensa, Benedikt M Schaarschmidt, Henning Reis, Marc Ingenwerth, Simon Bogner, Clemens Aigner, Christian Buchbender, Lale Umutlu, Gerald Antoch, Ken Herrmann, Philipp Heusch
OBJECTIVES: To compare the diagnostic performance of 18 F-FDG PET/MRI and 18 F-FDG PET/CT for primary and locoregional lymph node staging in non-small cell lung cancer (NSCLC). METHODS: In this prospective study, a total of 84 patients (51 men, 33 women, mean age 62.5 ± 9.1 years) with histopathologically confirmed NSCLC underwent 18 F-FDG PET/CT followed by 18 F-FDG PET/MRI in a single injection protocol. Two readers independently assessed T and N staging in separate sessions according to the seventh edition of the American Joint Committee on Cancer staging manual for 18 F-FDG PET/CT and 18 F-FDG PET/MRI, respectively...
August 3, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30069578/prognostic-value-of-posttreatment-18-f-fdg-pet-ct-and-predictors-of-metabolic-response-to-therapy-in-patients-with-locally-advanced-cervical-cancer-treated-with-concomitant-chemoradiation-therapy-an-analysis-of-intensity-and-volume-based-pet-parameters
#17
Giacomo Maria Lima, Antonella Matti, Giulio Vara, Giulia Dondi, Nicoletta Naselli, Eugenia Maria De Crescenzo, Alessio Giuseppe Morganti, Anna Myriam Perrone, Pierandrea De Iaco, Cristina Nanni, Stefano Fanti
PURPOSE: To investigate the prognostic value of posttreatment 18 F-FDG PET/CT in patients with locally advanced cervical cancer (LACC) treated with concomitant chemoradiation therapy (CCRT). The secondary aim was to assess the possible role of intensity-based and volume-based PET parameters including SUVmax, SUVmean, MTV and TLG, and clinical parameters including age, pathology, FIGO stage and nodal involvement as factors predicting response to treatment. METHODS: This retrospective study included 82 patients affected by LACC treated with CCRT...
August 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30069577/pet-imaging-of-egfr-expression-using-an-18-f-labeled-rna-aptamer
#18
Siyuan Cheng, Orit Jacobson, Guizhi Zhu, Zhen Chen, Steve H Liang, Rui Tian, Zhen Yang, Gang Niu, Xiaohua Zhu, Xiaoyuan Chen
OBJECTIVE: Epidermal growth factor receptor (EGFR) is a theranostic biomarker for a variety of cancer types. The aim of the present study was to develop an 18 F radiolabeled EGFR targeting RNA aptamer, and to investigate its ability to visualize and quantify EGFR in xenograft models. METHODS: Biolayer interferometry binding assay was used to detect the binding affinity of the alkyne-modified EGFR aptamer MinE07 (denoted as ME07) with recombinant human wild-type EGFR protein and the mutant EGFRvIII protein...
August 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30069576/piscom-a-new-procedure-for-epilepsy-combining-ictal-spect-and-interictal-pet
#19
Andrés Perissinotti, Aida Niñerola-Baizán, Sebastià Rubí, Mar Carreño, Berta Marti-Fuster, Javier Aparicio, Maria Mayoral, Antonio Donaire, Nuria Sanchez-Izquierdo, Nuria Bargalló, Jordi Rumiá, Teresa Boget, Francesca Pons, Francisco Lomeña, Domènec Ros, Javier Pavía, Xavier Setoain
PURPOSE: We present a modified version of the SISCOM procedure that uses interictal PET instead of interictal SPECT for seizure onset zone localization. We called this new nuclear imaging processing technique PISCOM (PET interictal subtracted ictal SPECT coregistered with MRI). METHODS: We retrospectively studied 23 patients (age range 4-61 years) with medically refractory epilepsy who had undergone MRI, ictal SPECT, interictal SPECT and interictal FDG PET and who had been seizure-free for at least 2 years after surgical treatment...
August 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30066157/simple-dichotomous-assessment-of-cranial-artery-inflammation-by-conventional-18f-fdg-pet-ct-shows-high-accuracy-for-the-diagnosis-of-giant-cell-arteritis-a-case-control-study
#20
Berit Dalsgaard Nielsen, Ib Tønder Hansen, Stine Kramer, Ate Haraldsen, Karin Hjorthaug, Trond Velde Bogsrud, June Anita Ejlersen, Lars Bjørn Stolle, Kresten Krarup Keller, Philip Therkildsen, Ellen-Margrethe Hauge, Lars Christian Gormsen
PURPOSE: To estimate the diagnostic accuracy of conventional 18F-FDG PET/CT of cranial arteries in the diagnosis of giant cell arteritis (GCA). METHODS: The study was a retrospective case-control study. The reference diagnosis was fulfillment of the 1990 ACR criteria for GCA. All patients had new-onset GCA. Conventional 18F-FDG PET/CT was performed before glucocorticoid treatment. Controls were age- and sex-matched patients with a previous history of malignant melanoma (MM) undergoing surveillance PET/CT >6 months after MM resection...
July 31, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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