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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/27924371/the-need-of-standardization-and-of-large-clinical-studies-in-an-emerging-indication-of-18-f-fdg-pet-the-autoimmune-encephalitis
#1
EDITORIAL
Silvia Morbelli, Javier Arbizu, Jan Booij, Ming-Kai Chen, Gael Chetelat, Donna J Cross, Mehdi Djekidel, Alexander Drzezga, Ozgul Ekmekcioglu, Valentina Garibotto, Swen Hesse, Kazunari Ishii, Lida Jafari Saraf, Adriaan A Lammertsma, Ian Law, Dana Mathews, Satoshi Minoshima, Karina Mosci, Marco Pagani, Sabina Pappata, Daniel Hillel Silverman, Alberto Signore, Elsmarieke Van De Giessen, Victor Villemagne, Henryk Barthel
No abstract text is available yet for this article.
December 6, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27913827/intra-lesional-spatial-correlation-of-static-and-dynamic-fet-pet-parameters-with-mri-based-cerebral-blood-volume-in-patients-with-untreated-glioma
#2
Jens Göttler, Mathias Lukas, Anne Kluge, Stephan Kaczmarz, Jens Gempt, Florian Ringel, Mona Mustafa, Bernhard Meyer, Claus Zimmer, Markus Schwaiger, Stefan Förster, Christine Preibisch, Thomas Pyka
PURPOSE: (18)F-fluorethyltyrosine-(FET)-PET and MRI-based relative cerebral blood volume (rCBV) have both been used to characterize gliomas. Recently, inter-individual correlations between peak static FET-uptake and rCBV have been reported. Herein, we assess the local intra-lesional relation between FET-PET parameters and rCBV. METHODS: Thirty untreated glioma patients (27 high-grade) underwent simultaneous PET/MRI on a 3 T hybrid scanner obtaining structural and dynamic susceptibility contrast sequences...
December 2, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27909770/the-natural-history-of-takotsubo-syndrome-a-two-year-follow-up-study-with-myocardial-sympathetic-and-perfusion-g-spect-imaging
#3
Stelvio Sestini, Francesco Pestelli, Mario Leoncini, Francesco Bellandi, Christian Mazzeo, Luigi Mansi, Ignasi Carrio, Antonio Castagnoli
PURPOSE: To investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T0) to post-onset conditions at 1 month (T1), 1-2 years (T2, T3). METHODS: Twenty-two patients (70 ± 11 years) underwent serial gated single photon emission tomography (G-SPECT) studies with (123)I-mIBG and (99m)Tc-Sestamibi. Statistics were performed using ANOVA/Sheffé post-hoc, correlation test, and receiver operating characteristic (ROC) curve analysis (p < 0...
December 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27909769/evaluation-of-131-i-scintigraphy-and-stimulated-thyroglobulin-levels-in-the-follow-up-of-patients-with-dtc-a-retrospective-analysis-of-1420-patients
#4
Jose Manuel Gonzalez Carvalho, Dennis Görlich, Otmar Schober, Christian Wenning, Burkhard Riemann, Frederik Anton Verburg, Alexis Vrachimis
AIM: To study the clinical yield of diagnostic whole body (131)I scintigraphy (DxWBS) in the follow-up of differentiated thyroid carcinoma (DTC) patients in relation to stimulated thyroglobulin (sTg) in the initial post-ablation setting, as well as in the setting of repeated monitoring in course of further DTC follow-up. METHODS: Data of 1420 thyroidectomized and radioiodine remnant-ablated DTC patients following a well-defined therapy and standardized follow-up protocol were evaluated...
December 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27909768/the-delicate-balance-between-present-and-future
#5
LETTER
Marco Spadafora, Leonardo Pace, Luigi Mansi
No abstract text is available yet for this article.
December 1, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900521/-18-f-fluorodihydroxyphenylalanine-pet-ct-in-pheochromocytoma-and-paraganglioma-relation-to-genotype-and-amino-acid-transport-system-l
#6
Chloé C Feral, Floriane S Tissot, Lionel Tosello, Nicolas Fakhry, Fréderic Sebag, Karel Pacak, David Taïeb
PURPOSE: F-FDOPA is a highly sensitive and specific radiopharmaceutical for pheochromocytoma and paraganglioma (PPGL) imaging. However, (18)F-FDOPA might be falsely negative in these tumors, especially those related to mutations in succinate dehydrogenase genes (SDHx). The aim of the present study was to evaluate the relationship between expression of L-DOPA transporters and (18)F-FDOPA PET imaging results in PPGL. METHODS: From 2007 to 2015, 175 patients with non-metastatic PPGL were evaluated by (18)F-FDOPA PET/CT for initial diagnosis/staging and follow-up...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900520/nuclear-medicine-imaging-of-multiple-myeloma-particularly-in-the-relapsed-setting
#7
REVIEW
Esther G M de Waal, Andor W J M Glaudemans, Carolien P Schröder, Edo Vellenga, Riemer H J A Slart
Multiple myeloma (MM) is characterized by a monoclonal plasma cell population in the bone marrow. Lytic lesions occur in up to 90 % of patients. For many years, whole-body X-ray (WBX) was the method of choice for detecting skeleton abnormalities. However, the value of WBX in relapsing disease is limited because lesions persist post-treatment, which restricts the capacity to distinguish between old, inactive skeletal lesions and new, active ones. Therefore, alternative techniques are necessary to visualize disease activity...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900519/early-dynamic-imaging-in-68-ga-psma-11-pet-ct-allows-discrimination-of-urinary-bladder-activity-and-prostate-cancer-lesions
#8
Christian Uprimny, Alexander Stephan Kroiss, Clemens Decristoforo, Josef Fritz, Boris Warwitz, Lorenza Scarpa, Llanos Geraldo Roig, Dorota Kendler, Elisabeth von Guggenberg, Jasmin Bektic, Wolfgang Horninger, Irene Johanna Virgolini
PURPOSE: PET/CT with (68)Ga-labelled prostate-specific membrane antigen (PSMA)-ligands has been proven to establish a promising imaging modality in the work-up of prostate cancer (PC) patients with biochemical relapse. Despite a high overall detection rate, the visualisation of local recurrence may be hampered by high physiologic tracer accumulation in the urinary bladder on whole body imaging, usually starting 60 min after injection. This study sought to verify whether early dynamic (68)Ga-PSMA-11 (HBED-CC)PET/CT can differentiate pathologic PC-related tracer uptake from physiologic tracer accumulation in the urinary bladder...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900518/the-reconstruction-algorithm-used-for-68-ga-psma-hbed-cc-pet-ct-reconstruction-significantly-influences-the-number-of-detected-lymph-node-metastases-and-coeliac-ganglia
#9
Thomas Krohn, Anita Birmes, Oliver H Winz, Natascha I Drude, Felix M Mottaghy, Florian F Behrendt, Frederik A Verburg
PURPOSE: To investigate whether the numbers of lymph node metastases and coeliac ganglia delineated on [(68)Ga]PSMA-HBED-CC PET/CT scans differ among datasets generated using different reconstruction algorithms. METHODS: Data were constructed using the BLOB-OS-TF, BLOB-OS and 3D-RAMLA algorithms. All reconstructions were assessed by two nuclear medicine physicians for the number of pelvic/paraaortal lymph node metastases as well the number of coeliac ganglia. Standardized uptake values (SUV) were also calculated in different regions...
November 29, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27896369/detection-rate-of-pet-ct-in-patients-with-biochemical-relapse-of-prostate-cancer-using-68-ga-psma-i-t-and-comparison-with-published-data-of-68-ga-psma-hbed-cc
#10
Christoph Berliner, Milena Tienken, Thorsten Frenzel, Yuske Kobayashi, Annabelle Helberg, Uve Kirchner, Susanne Klutmann, Dirk Beyersdorff, Lars Budäus, Hans-Jürgen Wester, Janos Mester, Peter Bannas
PURPOSE: To determine the detection rate of PET/CT in biochemical relapse of prostate cancer using [(68)Ga]PSMA I&T and to compare it with published detection rates of [(68)Ga]PSMA HBED-CC. METHODS: We performed a retrospective analysis in 83 consecutive patients with documented biochemical relapse after prostatectomy. All patients underwent whole body [(68)Ga]PSMA I&T PET/CT. PET/CT images were evaluated for presence of local recurrence, lymph node metastases, and distant metastases...
November 28, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27889802/f-18-labelled-psma-1007-biodistribution-radiation-dosimetry-and-histopathological-validation-of-tumor-lesions-in-prostate-cancer-patients
#11
Frederik L Giesel, B Hadaschik, J Cardinale, J Radtke, M Vinsensia, W Lehnert, C Kesch, Y Tolstov, S Singer, N Grabe, S Duensing, M Schäfer, O C Neels, W Mier, U Haberkorn, K Kopka, C Kratochwil
PURPOSE: The prostate-specific membrane antigen (PSMA) targeted positron-emitting-tomography (PET) tracer (68)Ga-PSMA-11 shows great promise in the detection of prostate cancer. However, (68)Ga has several shortcomings as a radiolabel including short half-life and non-ideal energies, and this has motivated consideration of (18)F-labelled analogs. (18)F-PSMA-1007 was selected among several (18)F-PSMA-ligand candidate compounds because it demonstrated high labelling yields, outstanding tumor uptake and fast, non-urinary background clearance...
November 26, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27888325/total-lesion-glycolysis-tlg-as-an-imaging-biomarker-in-metastatic-colorectal-cancer-patients-treated-with-regorafenib
#12
Yoojoo Lim, Ji-In Bang, Sae-Won Han, Jin Chul Paeng, Kyung-Hun Lee, Jee Hyun Kim, Gyeong Hoon Kang, Seung-Yong Jeong, Kyu Joo Park, Tae-You Kim
PURPOSE: This study was performed to evaluate whether fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) could predict treatment outcome of regorafenib in metastatic colorectal cancer (mCRC). METHODS: Previously treated refractory mCRC patients were enrolled into a prospective biomarker study of regorafenib. For this sub-study, the results of FDG PET/CT scans at baseline and after two cycles of treatment were analyzed. Various metabolic parameters obtained from PET images were analyzed in relation to treatment outcome...
November 25, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27882397/reply-by-l-maffioli
#13
LETTER
Lorenzo Maffioli, Luca Dellavedova, Luigia Florimonte
No abstract text is available yet for this article.
November 23, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27878594/healthy-brain-ageing-assessed-with-18f-fdg-pet-and-age-dependent-recovery-factors-after-partial-volume-effect-correction
#14
Stijn Bonte, Pieter Vandemaele, Stijn Verleden, Kurt Audenaert, Karel Deblaere, Ingeborg Goethals, Roel Van Holen
No abstract text is available yet for this article.
November 23, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27872957/utility-of-18-f-fluoroestradiol-18-f-fes-pet-ct-imaging-as-a-pharmacodynamic-marker-in-patients-with-refractory-estrogen-receptor-positive-solid-tumors-receiving-z-endoxifen-therapy
#15
Frank I Lin, E M Gonzalez, S Kummar, K Do, J Shih, S Adler, K A Kurdziel, A Ton, B Turkbey, P M Jacobs, S Bhattacharyya, A P Chen, J M Collins, J H Doroshow, P L Choyke, M L Lindenberg
BACKGROUND: Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because it bypasses potential drug resistance mechanisms attributable to patient variability in the expression of the hepatic microsomal enzyme CYP2D6. (18)F-FES is a positron emission tomography (PET) imaging agent which selectively binds to estrogen receptor alpha (ER-α) and has been used for non-invasive in vivo assessment of ER activity in tumors. This study utilizes (18)F-FES PET imaging as a pharmacodynamic biomarker in patients with ER+ tumors treated with Z-endoxifen...
November 21, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27864590/do-we-need-fdg-pet-ct-to-assess-atherosclerosis
#16
EDITORIAL
Nicolò Pipitone, Carlo Salvarani, Annibale Versari
No abstract text is available yet for this article.
November 18, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27853826/brain-perfusion-spect-for-brain-death-assessment
#17
Pedro Barata Silva Coelho, Ana Fernandes, Ana Oliveira, Teresa Faria, Jorge Pereira
No abstract text is available yet for this article.
November 16, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27847991/synthesis-and-pre-clinical-evaluation-of-a-new-class-of-high-affinity-18-f-labeled-psma-ligands-for-detection-of-prostate-cancer-by-pet-imaging
#18
James Kelly, Alejandro Amor-Coarasa, Anastasia Nikolopoulou, Dohyun Kim, Clarence Williams, Shashikanth Ponnala, John W Babich
PURPOSE: Current clinical imaging of PSMA-positive prostate cancer by positron emission tomography (PET) mainly features (68)Ga-labeled tracers, notably [(68)Ga]Ga-PSMA-HBED-CC. The longer half-life of fluorine-18 offers significant advantages over Ga-68, clinically and logistically. We aimed to develop high-affinity PSMA inhibitors labeled with fluorine-18 as alternative tracers for prostate cancer. METHODS: Six triazolylphenyl ureas and their alkyne precursors were synthesized from the Glu-urea-Lys PSMA binding moiety...
November 15, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27844106/lymphoma-current-status-of-clinical-and-preclinical-imaging-with-radiolabeled-antibodies
#19
REVIEW
Christopher G England, Lixin Rui, Weibo Cai
Lymphoma is a complex disease that arises from cells of the immune system with an intricate pathology. While lymphoma may be classified as Hodgkin or non-Hodgkin, each type of tumor is genetically and phenotypically different and highly invasive tissue biopsies are the only method to investigate these differences. Noninvasive imaging strategies, such as immunoPET, can provide a vital insight into disease staging, monitoring treatment response in patients, and dose planning in radioimmunotherapy. ImmunoPET imaging with radiolabeled antibody-based tracers may also assist physicians in optimizing treatment strategies and enhancing patient stratification...
November 14, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27838763/the-clinical-utility-of-fdg-pet-ct-among-solid-organ-transplant-recipients-suspected-of-malignancy-or-infection
#20
Neval E Wareham, J D Lundgren, C Da Cunha-Bang, F Gustafsson, M Iversen, H H Johannesen, A Kjær, A Rasmussen, H Sengeløv, S S Sørensen, B M Fischer
PURPOSE: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies. (18)F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic unresolved SOT recipients transplanted from January 2004 to May 2015. METHODS: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included...
November 12, 2016: European Journal of Nuclear Medicine and Molecular Imaging
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