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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/28429044/-68-ga-dotatate-pet-ct-in-recurrent-medullary-thyroid-carcinoma-a-lesion-by-lesion-comparison-with-111-in-octreotide-spect-ct-and-conventional-imaging
#1
Lilian Yuri Itaya Yamaga, Marcelo L Cunha, Guilherme C Campos Neto, Marcio R T Garcia, Ji H Yang, Cleber P Camacho, Jairo Wagner, Marcelo B G Funari
PURPOSE: The aim of this study was to prospectively compare the detection rate of (68)Ga-DOTATATE PET-CT with (111)In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. METHODS: Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent (68)Ga-DOTATATE PET-CT, (111)In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard...
April 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28421240/a-randomised-phase-ii-study-of-repeated-rhenium-188-hedp-combined-with-docetaxel-and-prednisone-versus-docetaxel-and-prednisone-alone-in-castration-resistant-prostate-cancer-crpc-metastatic-to-bone-the-taxium-ii-trial
#2
Joyce M van Dodewaard-de Jong, John M H de Klerk, Haiko J Bloemendal, Daniela E Oprea-Lager, Otto S Hoekstra, H Pieter van den Berg, Maartje Los, Aart Beeker, Marianne A Jonker, Joe M O'Sullivan, Henk M W Verheul, Alfons J M van den Eertwegh
BACKGROUND: Rhenium-188-HEDP is a beta-emitting radiopharmaceutical used for palliation of metastatic bone pain. We investigated whether the addition of rhenium-188-HEDP to docetaxel/prednisone improved efficacy of chemotherapy in patients with CRPC. METHODS: Patients with progressive CRPC and osteoblastic bone metastases were randomised for first-line docetaxel 75 mg/m(2) 3-weekly plus prednisone with or without 2 injections of rhenium-188-HEDP after the third (40 MBq/kg) and after the sixth (20 MBq/kg) cycle of docetaxel...
April 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28417160/diagnosis-of-recurrent-prostate-cancer-with-pet-ct-imaging-using-the-gastrin-releasing-peptide-receptor-antagonist-68-ga-rm2-preliminary-results-in-patients-with-negative-or-inconclusive-18-f-fluoroethylcholine-pet-ct
#3
Gesche Wieser, Ilinca Popp, H Christian Rischke, Vanessa Drendel, Anca-Ligia Grosu, Mark Bartholomä, Wolfgang A Weber, Rosalba Mansi, Ulrich Wetterauer, Wolfgang Schultze-Seemann, Philipp T Meyer, Cordula Annette Jilg
PURPOSE/BACKGROUND: [(18)F]fluoroethylcholine ((18)FECH) has been shown to be a valuable PET-tracer in recurrent prostate cancer (PCa), but still has limited accuracy. RM2 is a gastrin-releasing peptide receptor (GRPr) antagonist that binds to GRPr on PCa cells. Recent studies suggest that GRPr imaging with PET/CT is a promising technique for staging and restaging of PCa. We explore the value of GRPr-PET using the (68)Ga-labeled GRPr antagonist RM2 in a selected population of patients with biochemically recurrent PCa and a negative/inconclusive (18)FECH-PET/CT...
April 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28411336/fdg-pet-for-therapy-monitoring-in-hodgkin-and-non-hodgkin-lymphomas
#4
REVIEW
Sally F Barrington, Regine Kluge
PET using (18)F-FDG for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. PET/CT is nowadays used during treatment to assess chemosensitivity, with response-adapted therapy given according to 'interim' PET in clinical practice to adults and children with Hodgkin lymphoma. PET is also used to assess remission from disease and to predict prognosis in the pretransplant setting. Mature data have been reported for the common subtypes of aggressive B-cell lymphomas, with more recent data also supporting the use of PET for response assessment in T-cell lymphomas...
April 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28409221/-18-fluorodeoxyglucose-positron-emission-tomography-for-the-textural-features-of-cervical-cancer-associated-with-lymph-node-metastasis-and-histological-type
#5
Wei-Chih Shen, Shang-Wen Chen, Ji-An Liang, Te-Chun Hsieh, Kuo-Yang Yen, Chia-Hung Kao
BACKGROUND: In this study, we investigated the correlation between the lymph node (LN) status or histological types and textural features of cervical cancers on (18)F-fluorodeoxyglucose positron emission tomography/computed tomography. METHODS: We retrospectively reviewed the imaging records of 170 patients with International Federation of Gynecology and Obstetrics stage IB-IVA cervical cancer. Four groups of textural features were studied in addition to the maximum standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis (TLG)...
April 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28409220/pet-and-pet-ct-with-radiolabeled-choline-in-prostate-cancer-a-critical-reappraisal-of-20-years-of-clinical-studies
#6
REVIEW
Giampiero Giovacchini, Elisabetta Giovannini, Rossella Leoncini, Mattia Riondato, Andrea Ciarmiello
We here aim to provide a comprehensive and critical review of the literature concerning the clinical applications of positron emission tomography/computed tomography (PET/CT) with radiolabeled choline in patients with prostate cancer (PCa). We will initially briefly summarize the historical context that brought to the synthesis of [(11)C]choline, which occurred exactly 20 years ago. We have arbitrarily grouped the clinical studies in three different periods, according to the year in which they were published and according to their relation with their applications in urology, radiotherapy and oncology...
April 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28405728/clinical-feasibility-of-90-y-digital-pet-ct-for-imaging-microsphere-biodistribution-following-radioembolization
#7
Chadwick L Wright, Katherine Binzel, Jun Zhang, Evan J Wuthrick, Michael V Knopp
PURPOSE: The purpose of this study was to evaluate the clinical feasibility of next generation solid-state digital photon counting PET/CT (dPET/CT) technology and imaging findings in patients following (90)Y microsphere radioembolization in comparison with standard of care (SOC) bremsstrahlung SPECT/CT (bSPECT/CT). METHODS: Five patients underwent SOC (90)Y bremsstrahlung imaging immediately following routine radioembolization with 3.5 ± 1.7 GBq of (90)Y-labeled glass microspheres...
April 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28405727/the-role-of-18-f-fdg-pet-ct-in-the-detection-of-osteosarcoma-recurrence
#8
Andrea Angelini, Francesco Ceci, Paolo Castellucci, Tiziano Graziani, Giulia Polverari, Giulia Trovarelli, Emanuela Palmerini, Stefano Ferrari, Stefano Fanti, Pietro Ruggieri
AIM: The aim of this study was to investigate the diagnostic accuracy of (18)F-FDG-PET/CT in osteosarcoma patients suspicious for disease recurrence after adequate surgical therapy. METHODS: Inclusion criteria were: a) adequate surgical treatment for proven osteosarcoma and documented complete remission after therapy; b) (18)F-FDG-PET/CT performed during follow-up for clinical/diagnostic suspicion of relapse; c) new surgical treatment with excision of the suspected lesions; d) histological validation of (18)F-FDG-PET/CT findings...
April 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28405726/inter-heterogeneity-and-intra-heterogeneity-of-%C3%AE-v%C3%AE-3-in-non-small-cell-lung-cancer-and-small-cell-lung-cancer-patients-as-revealed-by-68-ga-rgd2-pet-imaging
#9
Fei Kang, Zhe Wang, Guoquan Li, Shengjun Wang, Daliang Liu, Mingru Zhang, Mingxuan Zhao, Weidong Yang, Jing Wang
PURPOSE: Integrin αvβ3 is the therapeutic target of the anti-angiogenic drug cilengitide. The objective of this study was to compare αvβ3 levels in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients, by using the positron emission tomography (PET) tracer (68)Ga-labeled dimerized-RGD ((68)Ga-RGD2). METHODS: Thirty-one patients with pathologically confirmed lung cancer were enrolled (21 were NSCLC and 10 were SCLC). PET/CT images were acquired using (68)Ga-RGD2...
April 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28396911/molecularly-targeted-therapies-in-cancer-a-guide-for-the-nuclear-medicine-physician
#10
REVIEW
S Lheureux, C Denoyelle, P S Ohashi, J S De Bono, F M Mottaghy
Molecular imaging continues to influence every aspect of cancer care including detection, diagnosis, staging and therapy response assessment. Recent advances in the understanding of cancer biology have prompted the introduction of new targeted therapy approaches. Precision medicine in oncology has led to rapid advances and novel approaches optimizing the use of imaging modalities in cancer care, research and development. This article focuses on the concept of targeted therapy in cancer and the challenges that exist for molecular imaging in cancer care...
April 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28396910/hypercalcemia-revealing-diffuse-granulomatous-myositis
#11
Weniko Caré, Estelle Blanc, Jean-Marie Cournac, Caroline Doutrelon, Marc Aletti, Stéphane Lecoules
No abstract text is available yet for this article.
April 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28389693/the-advantages-and-challenges-of-using-fdg-pet-ct-for-response-assessment-in-melanoma-in-the-era-of-targeted-agents-and-immunotherapy
#12
REVIEW
Annie N M Wong, Grant A McArthur, Michael S Hofman, Rodney J Hicks
The treatment of melanoma has been revolutionised in recent years by advances in the understanding of the genomic landscape of this disease, which has led to the development of new targeted therapeutic agents, and the ability to therapeutically manipulate the immune system through inhibition of cancer cell-T-cell interactions that prevent an adaptive immune response. While these therapeutic interventions have dramatically improved the prospects of survival for patients with advanced melanoma, they bring significant complexity to the interpretation of therapeutic response because their mechanisms and temporal profile of response vary considerably...
April 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28386656/the-round-table-approach-in-infective-endocarditis-cardiovascular-implantable-electronic-devices-infections-make-your-e-team-come-true
#13
EDITORIAL
Paola A Erba, Gilbert Habib, Andor W J M Glaudemans, Jose M Miro, Riemer H J A Slart
No abstract text is available yet for this article.
April 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28382512/microsurgery-guided-by-sequential-preoperative-lymphography-using-68-ga-neb-pet-and-mri-in-patients-with-lower-limb-lymphedema
#14
Xiao Long, Jingjing Zhang, Daming Zhang, Chao Gao, Chongwei Chi, Elan Yang, Huadan Xue, Lixin Lang, Gang Niu, Zhaohui Zhu, Fang Li, Xiaoyuan Chen
OBJECTIVE: The popularity of contemporary microsurgical techniques in treatment of lower-limb lymphedema calls for better visualization of the lymphatic system, both preoperatively and intra-operatively. The aim of this prospective study was to investigate the feasibility of a novel combination of (68)Ga-NEB positron emission tomography (PET) with magnetic resonance lymphography (MRL) in evaluating lymphedema and guiding surgical intervention. METHODS: A total of 11 patients (F 9, M 2, age range 29-69 y) with lower-limb lymphedema classified into stage I to III were recruited...
April 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28374119/sentinel-lymph-node-mapping-using-spect-ct-and-gamma-probe-in-endometrial-cancer-an-analysis-of-parameters-affecting-detection-rate
#15
Samine Sahbai, Florin-Andrei Taran, Annette Staebler, Diethelm Wallwiener, Christian la Fougère, Sara Brucker, Helmut Dittmann
PURPOSE: SPECT/CT after pericervical injection of technetium-99 m-nanocolloid was shown to be suitable for sentinel lymph node (SLN) mapping in endometrial cancer (EC). The aim of this study was to analyze factors affecting successful SLN detection by means of SPECT/CT such as imaging findings, patient characteristics and tumor biology in a large cohort of patients. METHODS: One hundred and forty-five consecutive patients suffering from EC who received pre-surgical SLN mapping at our institution between 2011 and 2016 were included in this analysis...
April 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28365789/single-scan-rest-stress-imaging-validation-in-a-porcine-model-with-18-f-flurpiridaz
#16
Nicolas J Guehl, Marc D Normandin, Dustin W Wooten, Guy Rozen, Arkadiusk Sitek, Jeremy Ruskin, Timothy M Shoup, Leon M Ptaszek, Georges El Fakhri, Nathaniel M Alpert
PURPOSE: (18)F-labeled myocardial flow agents are becoming available for clinical application but the ∼2 hour half-life of (18)F complicates their clinical application for rest-stress measurements. The goal of this work is to evaluate in a pig model a single-scan method which provides quantitative rest-stress blood flow in less than 15 minutes. METHODS: Single-scan rest-stress measurements were made using (18)F-Flurpiridaz. Nine scans were performed in healthy pigs and seven scans were performed in injured pigs...
April 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28364163/envisaging-an-alpha-therapy-programme-in-the-atomic-energy-establishments-the-priorities-and-the-nuances
#17
LETTER
Sandip Basu, Sharmila Banerjee
No abstract text is available yet for this article.
March 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28364162/18f-fdg-pet-ct-in-erdheim-chester-disease
#18
Rosa Fernández López, Irene Acevedo Báñez, Manuel Beltrán Robles, Isabel Borrego Dorado
No abstract text is available yet for this article.
March 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28364161/comparison-of-ct-and-pet-ct-for-biopsy-guidance-in-oncological-patients
#19
Juliano J Cerci, Elena Tabacchi, Mateos Bogoni, Dominique Delbeke, Carlos Cunha Pereira, Rodrigo J Cerci, Cassiano Krauzer, Danielle Giacometti Sakamoto, Stefano Fanti, João Vicente Vitola
PURPOSE: To compare FDG PET/CT and CT for the guidance of percutaneous biopsies with histological confirmation of lesions. METHODS: We prospectively evaluated 323 patients of whom 181 underwent FDG PET/CT-guided biopsy (total 188 biopsies) and 142 underwent CT-guided biopsy (total 146 biopsies). Biopsies were performed using the same PET/CT scanner with a fluoroscopic imaging system. Technical feasibility, clinical success and complication rates in the two groups were evaluated...
March 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28361189/personalized-177-lu-octreotate-peptide-receptor-radionuclide-therapy-of-neuroendocrine-tumours-a-simulation-study
#20
Michela Del Prete, François-Alexandre Buteau, Jean-Mathieu Beauregard
PURPOSE: Peptide receptor radionuclide therapy (PRRT) with (177)Lu-octreotate is commonly administered at empiric, fixed amounts of injected radioactivity (IA). This results in highly variable absorbed doses to critical organs and suboptimal treatment of most patients. The primary aims of this study were to design a personalized PRRT (P-PRRT) protocol based on dosimetry, and to perform a simulation of this protocol in a retrospective cohort of patients with neuroendocrine tumours, in order to assess the potential of P-PRRT to safely increase the absorbed dose to the tumour during a four-cycle induction course...
March 31, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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