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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29460027/could-short-thyroid-hormone-withdrawal-be-an-effective-strategy-for-radioiodine-remnant-ablation-in-differentiated-thyroid-cancer-patients
#1
Arnoldo Piccardo, Matteo Puntoni, Giulia Ferrarazzo, Luca Foppiani, Gianluca Bottoni, Vania Altrinetti, Giorgio Treglia, Mehrdad Naseri, Bassam Dib, Manlio Cabria, Pierpaolo Trimboli, Michela Massollo, Luca Giovanella
PURPOSE: Current guidelines recommend thyroid hormone withdrawal (THW) of 3-4 weeks before radioiodine remnant ablation (RRA) of differentiated thyroid carcinoma (DTC). We aimed to evaluate (1) the reliability of a shorter THW (i.e., 14 days) to achieve adequate TSH levels (i.e., 30 mU/l), (2) the association between length of THW and response to therapy, and (3) the potential association between pre-ablation TSH levels and patients' outcome. METHODS: After thyroidectomy, all patients started LT4 therapy, which was subsequently discontinued in order to perform RRA...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29460026/-11-c-acetate-pet-ct-a-potential-alternative-of-transcranial-biopsy-for-grading-cerebral-gliomas
#2
EDITORIAL
Jun Hatazawa
No abstract text is available yet for this article.
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29460025/combined-model-based-and-patient-specific-dosimetry-for-18-f-dcfpyl-a-psma-targeted-pet-agent
#3
Donika Plyku, Esther Mena, Steven P Rowe, Martin A Lodge, Zsolt Szabo, Steve Y Cho, Martin G Pomper, George Sgouros, Robert F Hobbs
PURPOSE: Prostate-specific membrane antigen (PSMA), a type-II integral membrane protein highly expressed in prostate cancer, has been extensively used as a target for imaging and therapy. Among the available PET radiotracers, the low molecular weight agents that bind to PSMA are proving particularly effective. We present the dosimetry results for18 F-DCFPyL in nine patients with metastatic prostate cancer. METHODS: Nine patients were imaged using sequential PET/CT scans at approximately 1, 12, 35 and 70 min, and a final PET/CT scan at approximately 120 min after intravenous administration of 321 ± 8 MBq (8...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29460024/defining-the-optimal-method-for-measuring-baseline-metabolic-tumour-volume-in-diffuse-large-b-cell-lymphoma
#4
Hajira Ilyas, N George Mikhaeel, Joel T Dunn, Fareen Rahman, Henrik Møller, Daniel Smith, Sally F Barrington
PURPOSE: Metabolic tumour volume (MTV) is a promising prognostic indicator in diffuse large B cell lymphoma (DLBCL). Optimal thresholds to divide patients into 'low' versus 'high' MTV groups depend on clinical characteristics and the measurement method. The aim of this study was to compare in consecutive unselected patients with DLBCL, different software algorithms and published methods of MTV measurement using FDG PET. METHOD: Pretreatment MTV was measured on 147 patients treated at Guy's and St Thomas' Hospital...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29455313/-18-f-fdg-pet-mr-enterography-for-the-assessment-of-inflammatory-activity-in-crohn-s-disease-comparison-of-different-mri-and-pet-parameters
#5
Yan Li, Karsten Beiderwellen, Felix Nensa, Johannes Grüneisen, Gustav Dobos, Ken Herrmann, Thomas Lauenstein, Lale Umutlu, Jost Langhorst
PURPOSE: To evaluate the diagnostic performance of integrated whole-body positron emission tomography (PET)/magnetic resonance (MR) enterography in patients with Crohn's disease (CD). METHODS: Fifty patients with known CD and recurrent symptoms underwent ileocolonoscopy (reference standard) as well as PET/MR enterography. Seven ileocolonic segments were endoscopically analysed using the Simplified Endoscopic Activity Score for Crohn's Disease (SES-CD) and additionally classified into three categories of inflammation (none, mild to moderate and severe ulcerative inflammation)...
February 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29455312/combining-baseline-tmtv-and-gene-profiling-for-a-better-risk-stratification-in-diffuse-large-b-cell-lymphoma
#6
EDITORIAL
Nicolas Aide, Charline Lasnon, Gandhi Damaj
No abstract text is available yet for this article.
February 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29453703/reply-interim-fdg-pet-ct-in-primary-mediastinal-diffuse-large-b-cell-lymphoma-really-almost-useless-procedure
#7
LETTER
Julien Lazarovici, Marie Terroir-Cassou-Mounat, David Ghez
No abstract text is available yet for this article.
February 17, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29453702/the-relationship-between-local-recurrences-and-distant-metastases-in-prostate-cancer-can-11-c-choline-pet-ct-contribute-to-understand-the-link
#8
Giampiero Giovacchini, Andrea Ciarmiello, Elisabetta Giovannini, Andrei Fodor, Cesare Cozzarini, Paola Mapelli, Elena Incerti, Nadia Di Muzio, Luigi Gianolli, Maria Picchio
PURPOSE: Previous studies in prostate cancer (PCa) patients tried to correlate the onset of local recurrence (LR) with the development of distant metastases and formulated, based on theoretical and experimental data, hypotheses linking the two events. We aimed to address this issue with 11 C-choline positron emission tomography/computed tomography (PET/CT). METHODS: This retrospective study included 491 PCa patients previously treated with radical prostatectomy who had undergone 11 C-choline PET/CT owing to biochemical failure...
February 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29453701/eanm-guidelines-for-radionuclide-therapy-of-bone-metastases-with-beta-emitting-radionuclides
#9
Daria Handkiewicz-Junak, Thorsten D Poeppel, Lisa Bodei, Cumali Aktolun, Samer Ezziddin, Francesco Giammarile, Roberto C Delgado-Bolton, Michael Gabriel
The skeleton is the most common metastatic site in patients with advanced cancer. Pain is a major healthcare problem in patients with bone metastases. Bone-seeking radionuclides that selectively accumulate in the bone are used to treat cancer-induced bone pain and to prolong survival in selected groups of cancer patients. The goals of these guidelines are to assist nuclear medicine practitioners in: (a) evaluating patients who might be candidates for radionuclide treatment of bone metastases using beta-emitting radionuclides such as strontium-89 ( 89 Sr), samarium-153 ( 153 Sm) lexidronam ( 153 Sm-EDTMP), and phosphorus-32 ( 32 P) sodium phosphate; (b) performing the treatments; and...
February 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29450576/immunopet-imaging-of-cd38-in-murine-lymphoma-models-using-89-zr-labeled-daratumumab
#10
Lei Kang, Dawei Jiang, Christopher G England, Todd E Barnhart, Bo Yu, Zachary T Rosenkrans, Rongfu Wang, Jonathan W Engle, Xiaojie Xu, Peng Huang, Weibo Cai
PURPOSE: CD38 is considered a potential biomarker for multiple myeloma (MM) and has shown a strong link with chronic lymphocytic leukemia due to high and uniform expression on plasma cells. In vivo evaluation of CD38 expression may provide useful information about lesion detection and prognosis of treatment in MM. In this study, immunoPET imaging with89 Zr-labeled daratumumab was used for differentiation of CD38 expression in murine lymphoma models to provide a potential non-invasive method for monitoring CD38 in the clinic...
February 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29445927/advantage-of-18-f-psma-1007-over-68-ga-psma-11-pet-imaging-for-differentiation-of-local-recurrence-vs-urinary-tracer-excretion
#11
Kambiz Rahbar, Matthias Weckesser, Hojjat Ahmadzadehfar, Michael Schäfers, Lars Stegger, Martin Bögemann
No abstract text is available yet for this article.
February 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29423530/life-is-not-black-and-white-nor-just-shades-of-gray
#12
EDITORIAL
T Beyer, R J Hicks, L S Freudenberg
No abstract text is available yet for this article.
February 8, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29411076/solitary-testicular-metastasis-from-prostate-cancer-a-case-report-diagnosed-by-pet-ct-with-psma
#13
Marcelo Livorsi da Cunha, Camila de Oliveira Rodrigues, Mariana Petruccelli Lima de Araújo, Celso Heitor de Freitas Junior, Robson Ferrigno
No abstract text is available yet for this article.
February 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29397402/interim-fdg-pet-ct-in-primary-mediastinal-diffuse-large-b-cell-lymphoma-really-almost-useless-procedure
#14
LETTER
Vít Procházka, Lenka Henzlová, Jaroslav Ptáček, Tomáš Papajík
No abstract text is available yet for this article.
February 3, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29396637/amyloid-and-tau-signatures-of-brain-metabolic-decline-in-preclinical-alzheimer-s-disease
#15
Tharick A Pascoal, Sulantha Mathotaarachchi, Monica Shin, Ah Yeon Park, Sara Mohades, Andrea L Benedet, Min Su Kang, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
PURPOSE: We aimed to determine the amyloid (Aβ) and tau biomarker levels associated with imminent Alzheimer's disease (AD) - related metabolic decline in cognitively normal individuals. METHODS: A threshold analysis was performed in 120 cognitively normal elderly individuals by modelling 2-year declines in brain glucose metabolism measured with [18F]fluorodeoxyglucose ([18F]FDG) as a function of [18F]florbetapir Aβ positron emission tomography (PET) and cerebrospinal fluid phosphorylated tau biomarker thresholds...
February 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29396636/imaging-%C3%AE-v%C3%AE-3-integrin-expression-in-skeletal-metastases-with-99mtc-maraciclatide-single-photon-emission-computed-tomography-detection-and-therapy-response-assessment
#16
Gary J R Cook, Gurdip K Azad, Benjamin P Taylor, Eugene Lee, Matthew S Morrison, Simon Hughes, Stephen Morris, Sarah Rudman, Simon Chowdhury, Vicky Goh
PURPOSE: Osteoclast activity is an important factor in the pathogenesis of skeletal metastases and is a potential therapeutic target. This study aimed to determine if selective uptake of 99mTc-maraciclatide, a radiopharmaceutical targeting αvβ3 integrin, occurs in prostate cancer (PCa) bone metastases and to observe the changes following systemic therapy. METHODS: The study group comprised 17 men with bone-predominant metastatic PCa who underwent whole-body planar and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging with 99mTc-maraciclatide before (n = 17) and 12 weeks after (n = 11) starting treatment with abiraterone...
February 2, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29387927/investigation-of-receptor-radionuclide-therapy-with-177lu-dotatate-in-patients-with-gep-nen-and-a-high-ki-67-proliferation-index
#17
Silvia Nicolini, Stefano Severi, Annarita Ianniello, Maddalena Sansovini, Alice Ambrosetti, Alberto Bongiovanni, Emanuela Scarpi, Francesca Di Mauro, Alice Rossi, Federica Matteucci, Giovanni Paganelli
PURPOSE: In the 2010 WHO classification, a Ki-67 proliferation index of 20% is the cut-off between intermediate-grade and high-grade gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN). However, in clinical practice, tumours with a Ki-67 index of >15% are often considered high grade and treated with chemotherapy. In 40-70% of high-grade NENs, somatostatin receptors are overexpressed, enabling peptide receptor radionuclide therapy (PRRT) to be performed. We investigated the role of PRRT with 177Lu-DOTATATE in patients with GEP-NEN and a high Ki-67 proliferation index...
February 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29387926/glioblastoma-multiforme-another-potential-application-for-68ga-psma-pet-ct-as-a-guide-for-targeted-therapy
#18
Jolanta Kunikowska, Królicki Bartosz, Królicki Leszek
No abstract text is available yet for this article.
January 31, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29379994/yuji-kuge-tohru-shiga-nagara-tamaki-editors-perspectives-on-nuclear-medicine-for-molecular-diagnosis-and-integrated-therapy-springer-open-access-tokyo-2016-isbn-978-4-431-55892-7
#19
Ida Annarumma, Luigi Mansi
No abstract text is available yet for this article.
January 27, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29372272/combined-evaluation-of-regional-coronary-artery-calcium-and-myocardial-perfusion-by-82rb-pet-ct-in-the-identification-of-obstructive-coronary-artery-disease
#20
Emilia Zampella, Wanda Acampa, Roberta Assante, Carmela Nappi, Valeria Gaudieri, Ciro Gabriele Mainolfi, Roberta Green, Valeria Cantoni, Mariarosaria Panico, Michele Klain, Mario Petretta, Piotr J Slomka, Alberto Cuocolo
PURPOSE: Cardiac imaging with PET/CT allows measurement of coronary artery calcium (CAC), myocardial perfusion and coronary vascular function. We investigated whether the combined assessment of regional CAC score, ischemic total perfusion deficit (ITPD) and quantitative coronary vascular function would further improve the diagnostic accuracy of PET/CT in predicting obstructive coronary artery disease (CAD). METHODS: We analyzed 113 patients with suspected CAD referred to 82Rb PET/CT myocardial perfusion imaging with available coronary angiographic data...
January 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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