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European Journal of Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29234846/fdg-pet-ct-as-a-powerful-tool-for-diagnosing-and-monitoring-treatment-outcomes-of-relapsing-polychondritis
#1
Pauline Baudart, Achille Aouba, Marie Beaufrère, Nicolas Aide
No abstract text is available yet for this article.
December 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29234845/eanm-guideline-for-radionuclide-therapy-with-radium-223-of-metastatic-castration-resistant-prostate-cancer
#2
Thorsten D Poeppel, Daria Handkiewicz-Junak, Michael Andreeff, Alexander Becherer, Andreas Bockisch, Eva Fricke, Lilli Geworski, Alexander Heinzel, Bernd J Krause, Thomas Krause, Markus Mitterhauser, Wilfried Sonnenschein, Lisa Bodei, Roberto C Delgado-Bolton, Michael Gabriel
Radium Ra-223 dichloride (radium-223, Xofigo®) is a targeted alpha therapy approved for the treatment of castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastatic disease. Radium-223 is the first targeted alpha therapy in this indication providing a new treatment option, with evidence of a significant survival benefit, both in overall survival and in the time to the first symptomatic skeletal-related event. The skeleton is the most common metastatic site in patients with advanced prostate cancer...
December 12, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29222685/prediction-of-outcome-using-pretreatment-18f-fdg-pet-ct-and-mri-radiomics-in-locally-advanced-cervical-cancer-treated-with-chemoradiotherapy
#3
François Lucia, Dimitris Visvikis, Marie-Charlotte Desseroit, Omar Miranda, Jean-Pierre Malhaire, Philippe Robin, Olivier Pradier, Mathieu Hatt, Ulrike Schick
PURPOSE: The aim of this study is to determine if radiomics features from 18fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) images could contribute to prognoses in cervical cancer. METHODS: One hundred and two patients (69 for training and 33 for testing) with locally advanced cervical cancer (LACC) receiving chemoradiotherapy (CRT) from 08/2010 to 12/2016 were enrolled in this study. 18F-FDG PET/CT and MRI examination [T1, T2, T1C, diffusion-weighted imaging (DWI)] were performed for each patient before CRT...
December 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29214417/diagnostic-and-prognostic-value-of-baseline-fdg-pet-ct-skeletal-textural-features-in-diffuse-large-b-cell-lymphoma
#4
Nicolas Aide, Marjolaine Talbot, Christophe Fruchart, Gandhi Damaj, Charline Lasnon
PURPOSE: Our purpose was to evaluate the diagnostic and prognostic value of skeletal textural features (TFs) on baseline FDG PET in diffuse large B cell lymphoma (DLBCL) patients. METHODS: Eighty-two patients with DLBCL who underwent a bone marrow biopsy (BMB) and a PET scan between December 2008 and December 2015 were included. Two readers blinded to the BMB results visually assessed PET images for bone marrow involvement (BMI) in consensus, and a third observer drew a volume of interest (VOI) encompassing the axial skeleton and the pelvis, which was used to assess skeletal TFs...
December 7, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29209750/founder-of-ejnm-passed-away
#5
EDITORIAL
Wolfram H Knapp
No abstract text is available yet for this article.
December 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29204718/superiority-of-68ga-dotatate-over-18f-fdg-and-anatomic-imaging-in-the-detection-of-succinate-dehydrogenase-mutation-sdhx-related-pheochromocytoma-and-paraganglioma-in-the-pediatric-population
#6
Abhishek Jha, Alexander Ling, Corina Millo, Garima Gupta, Bruna Viana, Frank I Lin, Peter Herscovitch, Karen T Adams, David Taïeb, Adam R Metwalli, W Marston Linehan, Alessandra Brofferio, Constantine A Stratakis, Electron Kebebew, Maya Lodish, Ali Cahid Civelek, Karel Pacak
PURPOSE: To evaluate and compare diagnostic performance of 68Ga-DOTA(0)-Tyr(3)-octreotate (68Ga-DOTATATE) with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) and anatomic imaging using computed tomography and/or magnetic resonance (CT/MR) imaging in detection of SDHx-related pheochromocytomas and paragangliomas (PPGLs) in pediatric patients. METHODS: Nine pediatric patients (5:4, girls:boys; 14.6 ± 2.0 years) with an SDHx-related mutation (SDHB:SDHA:SDHD, n = 7:1:1) were included in this retrospective study...
December 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29198033/all-that-glitters-is-not-gold-new-reconstruction-methods-using-deauville-criteria-for-patient-reporting
#7
LETTER
Sally F Barrington, Tom Sulkin, Adam Forbes, Peter W M Johnson
No abstract text is available yet for this article.
December 2, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29196789/prediction-of-functional-recovery-after-primary-pci-using-the-estimate-of-myocardial-salvage-in-gated-spect-early-after-acute-myocardial-infarction
#8
Raffaella Calabretta, Angelo Castello, Flavia Linguanti, Francesca Tutino, Alfonso Ciaccio, Cristina Giglioli, Roberto Sciagrà
PURPOSE: Primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) aims to achieve myocardial salvage (MS). Because the reference method for measuring MS requires myocardial perfusion imaging (MPI) after tracer injection before PCI, alternative approaches have been proposed, but none has gained wide acceptance. Gated SPECT MPI can assess infarct size (IS), but can also show myocardial stunning. Thus, we compared functional and perfusion abnormalities early after AMI to estimate MS, and to predict left ventricular ejection fraction (LVEF) recovery at follow-up...
December 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29192365/eanm-earl-fdg-pet-ct-accreditation-summary-results-from-the-first-200-accredited-imaging-systems
#9
Andres Kaalep, Terez Sera, Wim Oyen, Bernd J Krause, Arturo Chiti, Yan Liu, Ronald Boellaard
PURPOSE: From 2010 until July 2016, the EANM Research Ltd. (EARL) FDG-PET/CT accreditation program has collected over 2500 phantom datasets from approximately 200 systems and 150 imaging sites worldwide. The objective of this study is to report the findings and impact of the accreditation program on the participating PET/CT systems. METHODS: To obtain and maintain EARL accredited status, sites were required to complete and submit two phantom scans - calibration quality control (CalQC), using a uniform cylindrical phantom and image quality control (IQQC), using a NEMA NU2-2007 body phantom...
December 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29192364/liver-metastases-from-prostate-cancer-at-11c-choline-pet-ct-a-multicenter-retrospective-analysis
#10
Pietro Ghedini, I Bossert, L Zanoni, F Ceci, T Graziani, P Castellucci, V Ambrosini, F Massari, E Nobili, B Melotti, A Musto, S Zoboli, L Antunovic, M Kirienko, A Chiti, C Mosconi, A Ardizzoni, R Golfieri, S Fanti, C Nanni
AIM: During our daily clinical practice using 11C-Choline PET/CT for restaging patients affected by relapsing prostate cancer (rPCa) we noticed an unusual but significant occurrence of hypodense hepatic lesions with a different tracer uptake. Thus, we decided to evaluate the possible correlation between rPCa and these lesions as possible hepatic metastases. MATERIALS AND METHODS: We retrospectively enrolled 542 patients diagnosed with rPCa in biochemical relapse after a radical treatment (surgery and/or radiotherapy)...
November 30, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29188300/favorable-versus-unfavorable-prognostic-groups-by-post-chemoradiation-fdg-pet-imaging-in-node-positive-esophageal-squamous-cell-carcinoma-patients-treated-with-definitive-chemoradiotherapy
#11
Wing-Keen Yap, Yu-Chuan Chang, Chia-Hsun Hsieh, Yin-Kai Chao, Chien-Cheng Chen, Ming-Chieh Shih, Tsung-Min Hung
PURPOSE: Our purpose was to examine the prognostic value of post-CRT PET based on the presence or absence of FDG-avid metastatic lymph node(s) and metabolic response of the primary tumor in patients with clinically node-positive ESCC treated with definitive chemoradiotherapy (dCRT). METHODS: We identified 108 eligible patients treated by chemoradiotherapy (CRT) with or without resection from our prospectively collected database. Absence of FDG-avid metastatic lymph node with at least partial response of the primary tumor on PET scan after initial CRT was defined as the Post-CRT PET favorable group (yPET-F), and otherwise as unfavorable group (yPET-U)...
November 30, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29185010/preliminary-results-on-response-assessment-using-68ga-hbed-cc-psma-pet-ct-in-patients-with-metastatic-prostate-cancer-undergoing-docetaxel-chemotherapy
#12
Anna Katharina Seitz, Isabel Rauscher, Bernhard Haller, Markus Krönke, Sophia Luther, Matthias M Heck, Thomas Horn, Jürgen E Gschwend, Markus Schwaiger, Matthias Eiber, Tobias Maurer
PURPOSE: To investigate the value of 68Ga-HBED-CC PSMA (68Ga-PSMA) PET/CT for response assessment in metastatic castration-sensitive and castration-resistant prostate cancer (mCSPC and mCRPC) during docetaxel chemotherapy. METHODS: 68Ga-PSMA PET/CT was performed in seven mCSPC patients before and after six cycles of upfront docetaxel chemotherapy and in 16 mCRPC patients before and after three cycles of palliative docetaxel chemotherapy. Radiographic treatment response was evaluated separately on the 68Ga-PSMA PET and CT datasets...
November 28, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181566/could-68ga-somatostatin-analogues-be-an-important-alternative-to-18f-dopa-pet-ct-in-pediatrics
#13
EDITORIAL
Arnoldo Piccardo, Giorgio Treglia
No abstract text is available yet for this article.
November 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29177707/a-first-in-man-pet-study-of-18f-pss232-a-fluorinated-abp688-derivative-for-imaging-metabotropic-glutamate-receptor-subtype-5
#14
Geoffrey Warnock, Michael Sommerauer, Linjing Mu, Gloria Pla Gonzalez, Susanne Geistlich, Valerie Treyer, Roger Schibli, Alfred Buck, Stefanie D Krämer, Simon M Ametamey
PURPOSE: Non-invasive imaging of metabotropic glutamate receptor 5 (mGlu5) in the brain using PET is of interest in e.g., anxiety, depression, and Parkinson's disease. Widespread application of the most widely used mGlu5 tracer, [11C]ABP688, is limited by the short physical half-life of carbon-11. [18F]PSS232 is a fluorinated analog with promising preclinical properties and high selectivity and specificity for mGlu5. In this first-in-man study, we evaluated the brain uptake pattern and kinetics of [18F]PSS232 in healthy volunteers...
November 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29177706/prognostic-value-of-vasodilator-response-using-rubidium-82-positron-emission-tomography-myocardial-perfusion-imaging-in-patients-with-coronary-artery-disease
#15
Punitha Arasaratnam, Masoud Sadreddini, Yeung Yam, Vinay Kansal, Sharmila Dorbala, Marcelo F Di Carli, Rob S Beanlands, Michael E Merhige, Brent A Williams, Emir Veledar, James K Min, Li Chen, Terrence D Ruddy, Guido Germano, Daniel S Berman, Leslee J Shaw, Benjamin J W Chow
BACKGROUND: Prognostic value of positron emission tomography (PET) myocardial perfusion imaging (MPI) is well established. There is paucity of data on how the prognostic value of PET relates to the hemodynamic response to vasodilator stress. We hypothesize that inadequate hemodynamic response will affect the prognostic value of PET MPI. METHODS AND RESULTS: Using a multicenter rubidium (Rb)-82 PET registry, 3406 patients who underwent a clinically indicated rest/stress PET MPI with a vasodilator agent were analyzed...
November 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29177871/tumour-functional-sphericity-from-pet-images-prognostic-value-in-nsclc-and-impact-of-delineation-method
#16
Mathieu Hatt, Baptiste Laurent, Hadi Fayad, Vincent Jaouen, Dimitris Visvikis, Catherine Cheze Le Rest
PURPOSE: Sphericity has been proposed as a parameter for characterizing PET tumour volumes, with complementary prognostic value with respect to SUV and volume in both head and neck cancer and lung cancer. The objective of the present study was to investigate its dependency on tumour delineation and the resulting impact on its prognostic value. METHODS: Five segmentation methods were considered: two thresholds (40% and 50% of SUVmax), ant colony optimization, fuzzy locally adaptive Bayesian (FLAB), and gradient-aided region-based active contour...
November 25, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29177870/dosimetric-parameters-predicting-contralateral-liver-hypertrophy-after-unilobar-radioembolization-of-hepatocellular-carcinoma
#17
Xavier Palard, Julien Edeline, Yan Rolland, Samuel Le Sourd, Marc Pracht, Sophie Laffont, Laurence Lenoir, Karim Boudjema, Thomas Ugen, Vanessa Brun, Habiba Mesbah, Laure-Anne Haumont, Pascal Loyer, Etienne Garin
PURPOSE: This study aimed at identifying prior therapy dosimetric parameters using 99mTc-labeled macro-aggregates of albumin (MAA) that are associated with contralateral hepatic hypertrophy occurring after unilobar radioembolization of hepatocellular carcinoma (HCC) performed with 90Y-loaded glass microspheres. METHODS: The dosimetry data of 73 HCC patients were collected prior to the treatment with 90Y-loaded microspheres for unilateral disease. The injected liver dose (ILD), the tumor dose (TD) and healthy injected liver dose (HILD) were calculated based on MAA quantification...
November 25, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29177538/invited-editorial-for-the-paper-by-silvoniemi-et-al-repeatability-of-tumor-hypoxia-imaging-using-18f-ef5-pet-ct-in-head-and-neck-cancer-in-this-issue-of-ejnmmi
#18
EDITORIAL
Cameron J Koch
No abstract text is available yet for this article.
November 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29167923/preoperative-prediction-of-microvascular-invasion-of-hepatocellular-carcinoma-using-18-f-fdg-pet-ct-a-multicenter-retrospective-cohort-study
#19
Seung Hyup Hyun, Jae Seon Eo, Bong-Il Song, Jeong Won Lee, Sae Jung Na, Il Ki Hong, Jin Kyoung Oh, Yong An Chung, Tae-Sung Kim, Mijin Yun
PURPOSE: The aim of this study was to assess the potential of tumor (18)F-fluorodeoxyglucose (FDG) avidity as a preoperative imaging biomarker for the prediction of microvascular invasion (MVI) of hepatocellular carcinoma (HCC). METHODS: One hundred and fifty-eight patients diagnosed with Barcelona Clinic Liver Cancer stages 0 or A HCC (median age, 57 years; interquartile range, 50-64 years) who underwent (18)F-FDG positron emission tomography with computed tomography (PET/CT) before curative surgery at seven university hospitals were included...
November 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29164302/impact-of-initial-myocardial-perfusion-imaging-versus-invasive-coronary-angiography-on-outcomes-in-coronary-artery-disease-a-nationwide-cohort-study
#20
Guang-Uei Hung, Kuan-Yin Ko, Cheng-Li Lin, Ruoh-Fang Yen, Chia-Hung Kao
PURPOSE: In patients with stable coronary artery disease (CAD), two main options exist to guide management: initial invasive coronary angiography (CAG), or selective CAG after risk stratification using myocardial perfusion imaging (MPI). This study compared clinical outcomes between these two strategies in a large, real-world population. METHODS: The initial cohort comprised 1,000,000 randomly selected patients who had been entered in the National Health Insurance Research Database of Taiwan between 2000 and 2011...
November 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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