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Diabetes Care

Neda Laiteerapong, Sandra A Ham, Yue Gao, Howard H Moffet, Jennifer Y Liu, Elbert S Huang, Andrew J Karter
OBJECTIVE: To examine for a legacy effect of early glycemic control on diabetic complications and death. RESEARCH DESIGN AND METHODS: This cohort study of managed care patients with newly diagnosed type 2 diabetes and 10 years of survival (1997-2013, average follow-up 13.0 years, N = 34,737) examined associations between HbA1c <6.5% (<48 mmol/mol), 6.5% to <7.0% (48 to <53 mmol/mol), 7.0% to <8.0% (53 to <64 mmol/mol), 8.0% to <9.0% (64 to <75 mmol/mol), or ≥9...
August 13, 2018: Diabetes Care
J Salas-Salvadó, M Bulló, N Babio, M Á Martínez-González, N Ibarrola-Jurado, J Basora, R Estruch, M I Covas, D Corella, F Arós, V Ruiz-Gutiérrez, E Ros
No abstract text is available yet for this article.
August 13, 2018: Diabetes Care
Andrés Díaz-López, Nancy Babio, Miguel A Martínez-González, Dolores Corella, Antonio J Amor, Montse Fitó, Ramon Estruch, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Josep Basora, F Javier Basterra-Gortari, Vicente Zanon-Moreno, Miguel Ángel Muñoz, Jordi Salas-Salvadó
No abstract text is available yet for this article.
August 13, 2018: Diabetes Care
Hunter Wessells, Barbara H Braffett, Sarah K Holt, Alan M Jacobson, John W Kusek, Catherine Cowie, Rodney L Dunn, Aruna V Sarma
OBJECTIVE: Type 1 diabetes has been associated with high rates of urinary and sexual problems, but the cumulative burden and overlap of these complications are unknown. We sought to determine prevalence of urological complications in persons with type 1 diabetes, associations with clinical and diabetes-related factors, and rates of emergence, persistence, and remission. RESEARCH DESIGN AND METHODS: This ancillary longitudinal study among participants in the Diabetes Control and Complications Trial and observational follow-up study Epidemiology of Diabetes Interventions and Complications (652 women and 713 men) was conducted in 2003 and 2010/2011...
August 13, 2018: Diabetes Care
Yu-Feng Lin, Shuei-Liong Lin, Tao-Min Huang, Shao-Yu Yang, Tai-Shuan Lai, Likwang Chen, Vin-Cent Wu, Tzong-Shinn Chu, Kwan-Dun Wu
OBJECTIVE: Acute kidney injury (AKI) is related to a high prevalence of insulin resistance. However, information is lacking on the sequelae of further metabolic change among AKI requiring dialysis in patients who could be weaned off dialysis (acute kidney disease [AKD]). RESEARCH DESIGN AND METHODS: Using the National Health Insurance Research Database from 2000 to 2010, with the exclusion of those with diabetes at the start, we identified 3,307 subjects with AKD and 9,921 matched control subjects from 963,037 hospitalized patients for the comparison of the outcomes, including new-onset diabetes and all-cause mortality...
August 13, 2018: Diabetes Care
Julia A Critchley, Iain M Carey, Tess Harris, Stephen DeWilde, Fay J Hosking, Derek G Cook
OBJECTIVE: Diabetes mellitus (DM) increases the risk of infections, but the effect of better control has not been thoroughly investigated. RESEARCH DESIGN AND METHODS: With the use of English primary care data, average glycated hemoglobin (HbA1c ) during 2008-2009 was estimated for 85,312 patients with DM ages 40-89 years. Infection rates during 2010-2015 compiled from primary care, linked hospital, and mortality records were estimated across 18 infection categories and further summarized as any requiring a prescription or hospitalization or as cause of death...
August 13, 2018: Diabetes Care
Anca Jivanescu, Cosmina I Bondor, Rodica Pop-Busui, Ioan A Veresiu, Diana I Sima, Daniel-Tudor Cosma, Bogdan Florea, Norina A Gavan
No abstract text is available yet for this article.
August 13, 2018: Diabetes Care
Julio Rosenstock, Alice Cheng, Robert Ritzel, Zsolt Bosnyak, Christine Devisme, Anna M G Cali, Jochen Sieber, Peter Stella, Xiangling Wang, Juan Frias, Ronan Roussel, Geremia B Bolli
OBJECTIVE: To compare insulin glargine 300 units/mL (Gla-300) versus insulin degludec 100 units/mL (IDeg-100) in this first head-to-head randomized controlled trial. RESEARCH DESIGN AND METHODS: BRIGHT (NCT02738151) was a multicenter, open-label, active-controlled, two-arm, parallel-group, 24-week, noninferiority study in insulin-naive patients with uncontrolled type 2 diabetes. Participants were randomized 1:1 to evening dosing with Gla-300 ( N = 466) or IDeg-100 ( N = 463), titrated to fasting self-monitored plasma glucose of 80-100 mg/dL...
August 13, 2018: Diabetes Care
Patrick G Gavin, Jane A Mullaney, Dorothy Loo, Kim-Anh Lê Cao, Peter A Gottlieb, Michelle M Hill, Danny Zipris, Emma E Hamilton-Williams
OBJECTIVE: Dysbiosis of the gut microbiota has been linked to disease pathogenesis in type 1 diabetes, yet the functional consequences to the host of this dysbiosis are unknown. We investigated the functional interactions between the microbiota and the host associated with type 1 diabetes disease risk. RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of stool samples from subjects with recent-onset type 1 diabetes ( n = 33), islet autoantibody-positive subjects ( n = 17), low-risk autoantibody-negative subjects ( n = 29), and healthy subjects ( n = 22)...
August 12, 2018: Diabetes Care
Jane L Chiang, David M Maahs, Katharine C Garvey, Korey K Hood, Lori M Laffel, Stuart A Weinzimer, Joseph I Wolfsdorf, Desmond Schatz
No abstract text is available yet for this article.
August 9, 2018: Diabetes Care
Gregory P Forlenza, Zoey Li, Bruce A Buckingham, Jordan E Pinsker, Eda Cengiz, R Paul Wadwa, Laya Ekhlaspour, Mei Mei Church, Stuart A Weinzimer, Emily Jost, Tatiana Marcal, Camille Andre, Lori Carria, Vance Swanson, John W Lum, Craig Kollman, William Woodall, Roy W Beck
OBJECTIVE: This study evaluated a new insulin delivery system designed to reduce insulin delivery when trends in continuous glucose monitoring (CGM) glucose concentrations predict future hypoglycemia. RESEARCH DESIGN AND METHODS: Individuals with type 1 diabetes ( n = 103, age 6-72 years, mean HbA1c 7.3% [56 mmol/mol]) participated in a 6-week randomized crossover trial to evaluate the efficacy and safety of a Tandem t:slim X2 pump with Basal-IQ integrated with a Dexcom G5 sensor and a predictive low-glucose suspend algorithm (PLGS) compared with sensor-augmented pump (SAP) therapy...
August 8, 2018: Diabetes Care
Jean Debédat, Nataliya Sokolovska, Muriel Coupaye, Simona Panunzi, Rima Chakaroun, Laurent Genser, Garance de Turenne, Jean-Luc Bouillot, Christine Poitou, Jean-Michel Oppert, Matthias Blüher, Michael Stumvoll, Geltrude Mingrone, Séverine Ledoux, Jean-Daniel Zucker, Karine Clément, Judith Aron-Wisnewsky
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) induces type 2 diabetes remission (DR) in 60% of patients at 1 year, yet long-term relapse occurs in half of these patients. Scoring methods to predict DR outcomes 1 year after surgery that include only baseline parameters cannot accurately predict 5-year DR (5y-DR). We aimed to develop a new score to better predict 5y-DR. RESEARCH DESIGN AND METHODS: We retrospectively included 175 RYGB patients with type 2 diabetes with 5-year follow-up...
August 6, 2018: Diabetes Care
Serge A Jabbour, Juan P Frìas, Elise Hardy, Azazuddin Ahmed, Hui Wang, Peter Öhman, Cristian Guja
OBJECTIVE: Among patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin combination produced greater reductions in glycemia, weight, and systolic blood pressure (SBP) at 28 weeks than exenatide QW or dapagliflozin alone (DURATION-8). Here, we investigated the safety and maintenance of efficacy at 52 weeks, after a 24-week extension. RESEARCH DESIGN AND METHODS: This phase 3, multicenter, double-blind study randomized adults with type 2 diabetes (glycated hemoglobin [HbA1c ] 8...
August 6, 2018: Diabetes Care
Jin J Zhou, Dawn C Schwenke, Gideon Bahn, Peter Reaven
OBJECTIVE: There is uncertainty about the importance of glycemic variability in cardiovascular complications in patients with type 2 diabetes. Using the Veteran Affairs Diabetes Trial (VADT), we investigated the association between variation in fasting glucose and glycated hemoglobin (HbA1c ) over time with the incidence of cardiovascular disease (CVD) and assessed whether this is influenced by intensive or standard glycemic control. RESEARCH DESIGN AND METHODS: During the VADT, fasting glucose and HbA1c were measured every 3 months for up to 84 months in 1,791 individuals...
August 6, 2018: Diabetes Care
Miranda M Broadney, Britni R Belcher, David A Berrigan, Robert J Brychta, Ira L Tigner, Faizah Shareef, Alexia Papachristopoulou, Jacob D Hattenbach, Elisabeth K Davis, Sheila M Brady, Shanna B Bernstein, Amber B Courville, Bart E Drinkard, Kevin P Smith, Douglas R Rosing, Pamela L Wolters, Kong Y Chen, Jack A Yanovski
OBJECTIVE: Sedentary children have greater risk of developing abnormalities in glucose homeostasis. We investigated whether interrupting sedentary behavior (sitting) with very short periods of walking would improve glucose metabolism without affecting dietary intake in children with overweight or obesity. We hypothesized that interrupting sitting with short bouts of moderate-intensity walking would decrease insulin area under the curve (AUC) during an oral glucose tolerance test (OGTT) compared with uninterrupted sitting...
August 6, 2018: Diabetes Care
Tomi T Laitinen, Joel Nuotio, Markus Juonala, Harri Niinikoski, Suvi Rovio, Jorma S A Viikari, Tapani Rönnemaa, Costan G Magnussen, Eero Jokinen, Hanna Lagström, Antti Jula, Olli Simell, Olli T Raitakari, Katja Pahkala
OBJECTIVE: We examined whether success in achieving the key targets of an infancy-onset 20-year dietary intervention associated with insulin sensitivity and serum lipids from early childhood to young adulthood. RESEARCH DESIGN AND METHODS: The sample comprised 941 children participating in the prospective, randomized Special Turku Coronary Risk Factor Intervention Project (STRIP). Dietary counseling was given biannually based on the Nordic Nutrition Recommendations with the main aim to improve the quality of dietary fat in children's diets and the secondary aim to promote intake of vegetables, fruits, and whole-grain products...
August 2, 2018: Diabetes Care
Mathilde Nativel, Fabrice Schneider, Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Olivier Meilhac, Philippe Rondeau, Elena Burillo, Maxime Cournot, Louis Potier, Gilberto Velho, Michel Marre, Ronan Roussel, Vincent Rigalleau, Kamel Mohammedi, Samy Hadjadj
OBJECTIVE: Inflammation and oxidative stress play an important role in the pathogenesis of lower-extremity artery disease (LEAD). We assessed the prognostic values of inflammatory and redox status biomarkers on the risk of LEAD in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: Plasma concentrations of tumor necrosis factor-α receptor 1 (TNFR1), angiopoietin-like 2, ischemia-modified albumin (IMA), fluorescent advanced glycation end products, protein carbonyls, and total reductive capacity of plasma were measured at baseline in the SURDIAGENE (Survie, Diabete de type 2 et Genetique) cohort...
August 2, 2018: Diabetes Care
Sonya S Deschênes, Eva Graham, Mika Kivimäki, Norbert Schmitz
OBJECTIVE: Adverse childhood experiences (ACEs) are associated with an increased risk of diabetes in adulthood. However, the potential mediating roles of depression and cardiometabolic dysregulations in this association are not clear. RESEARCH DESIGN AND METHODS: Prospective data were from the Whitehall II cohort study, with the phase 5 assessment (1997-1999) serving as baseline ( n = 5,093, age range = 44-68 years, 27.3% female). ACEs were retrospectively reported at phase 5...
August 2, 2018: Diabetes Care
John M Dennis, William E Henley, Michael N Weedon, Mike Lonergan, Lauren R Rodgers, Angus G Jones, William T Hamilton, Naveed Sattar, Salim Janmohamed, Rury R Holman, Ewan R Pearson, Beverley M Shields, Andrew T Hattersley
OBJECTIVE: The choice of therapy for type 2 diabetes after metformin is guided by overall estimates of glycemic response and side effects seen in large cohorts. A stratified approach to therapy would aim to improve on this by identifying subgroups of patients whose glycemic response or risk of side effects differs markedly. We assessed whether simple clinical characteristics could identify patients with differing glycemic response and side effects with sulfonylureas and thiazolidinediones...
August 2, 2018: Diabetes Care
Tianyi Huang, Brian M Lin, Meir J Stampfer, Shelley S Tworoger, Frank B Hu, Susan Redline
OBJECTIVE: Multiple lines of evidence support a complex relationship between obstructive sleep apnea (OSA) and diabetes. However, no population-based study has evaluated the potential bidirectional association between these two highly prevalent disorders. RESEARCH DESIGN AND METHODS: We followed 146,519 participants from the Nurses' Health Study (NHS; 2002-2012), Nurses' Health Study II (NHSII; 1995-2013), and Health Professionals Follow-up Study (HPFS; 1996-2012) who were free of diabetes, cardiovascular disease, and cancer at baseline...
August 2, 2018: Diabetes Care
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