journal
MENU ▼
Read by QxMD icon Read
search

Diabetes Care

journal
https://www.readbyqxmd.com/read/29212825/intensive-blood-pressure-lowering-in-patients-with-and-patients-without-type-2-diabetes-a-pooled-analysis-from-two-randomized-trials
#1
Tom F Brouwer, Jim T Vehmeijer, Deborah N Kalkman, Wouter R Berger, Bert-Jan H van den Born, Ron J Peters, Reinoud E Knops
OBJECTIVE: The Action to Control Cardiovascular Risk in Diabetes Blood Pressure (ACCORD-BP) study did not find a significant beneficial effect of intensive systolic blood pressure (SBP) lowering on cardiovascular events in hypertensive patients with type 2 diabetes mellitus (T2DM), while the Systolic Blood Pressure Intervention Trial (SPRINT) did find a significant beneficial effect in patients without T2DM. The objective of this analysis was to assess the effect of both T2DM and baseline cardiovascular disease (CVD) risk on the treatment effect of intensive blood pressure lowering...
December 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29212824/targeted-microbiome-intervention-by-microencapsulated-delayed-release-niacin-beneficially-affects-insulin-sensitivity-in-humans
#2
Daniela Fangmann, Eva-Maria Theismann, Kathrin Türk, Dominik M Schulte, Isabelle Relling, Katharina Hartmann, Julia K Keppler, Jörg-Rainer Knipp, Ateequr Rehman, Femke-Anouska Heinsen, Andre Franke, Lennart Lenk, Sandra Freitag-Wolf, Esther Appel, Stanislav Gorb, Charles Brenner, Dirk Seegert, Georg H Waetzig, Philip Rosenstiel, Stefan Schreiber, Karin Schwarz, Matthias Laudes
OBJECTIVE: Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially affect the host-microbiome interaction in rodent models. RESEARCH DESIGN AND METHODS: We characterized more than 500 human subjects with different metabolic phenotypes regarding their niacin (nicotinic acid [NA] and nicotinamide [NAM]) status and their gut microbiome. In addition, NA and NAM delayed-release microcapsules were engineered and examined in vitro and in vivo in two human intervention studies (bioavailability study and proof-of-concept/safety study)...
December 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29208655/obstructive-sleep-apnea-and-diabetes-independently-add-to-cardiovascular-risk-after-coronary-revascularization
#3
LETTER
Chieh Yang Koo, Luciano F Drager, Rishi Sethi, Hee-Hwa Ho, Thet Hein, Man-Hong Jim, Bee-Choo Tai, Jun-Jie Zhang, Chi-Hang Lee
No abstract text is available yet for this article.
December 5, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29208654/advanced-glycation-end-products-oxidation-products-and-incident-cardiovascular-events-in-patients-with-type-2-diabetes
#4
Juraj Koska, Aramesh Saremi, Scott Howell, Gideon Bahn, Barbora De Courten, Henry Ginsberg, Paul J Beisswenger, Peter D Reaven
OBJECTIVE: The goal of this study was to determine whether plasma levels of advanced glycation end products (AGE) and oxidation products (OP) predict the incidence of cardiovascular disease (CVD) in type 2 diabetes. RESEARCH DESIGN AND METHODS: Five specific AGE (methylglyoxal hydroimidazolone, carboxymethyl lysine, carboxyethyl lysine, 3-deoxyglucosone hydroimidazolone, and glyoxal hydroimidazolone) and two OP (2-aminoadipic acid and methionine sulfoxide [MetSO]) were measured at baseline in two intensive glucose-lowering studies: (1) a subcohort of the Veterans Affairs Diabetes Trial (VADT) (n = 445) and (2) a nested case-control subgroup from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study (n = 271)...
December 5, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29208653/twin-pregnancy-with-gestational-diabetes-mellitus-a-double-whammy
#5
LETTER
Sara Ooi, Vincent W Wong
No abstract text is available yet for this article.
December 5, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29203583/how-does-empagliflozin-reduce-cardiovascular-mortality-insights-from-a-mediation-analysis-of-the-empa-reg-outcome-trial
#6
Silvio E Inzucchi, Bernard Zinman, David Fitchett, Christoph Wanner, Ele Ferrannini, Martin Schumacher, Claudia Schmoor, Kristin Ohneberg, Odd Erik Johansen, Jyothis T George, Stefan Hantel, Erich Bluhmki, John M Lachin
OBJECTIVE: In the EMPA-REG OUTCOME trial involving 7,020 patients with type 2 diabetes and established cardiovascular (CV) disease, empagliflozin given in addition to standard of care reduced the risk of CV death by 38% versus placebo (hazard ratio [HR] 0.62 [95% CI 0.49, 0.77]). This exploratory mediation analysis assesses the extent to which treatment group differences in covariates during the trial contributed to CV death risk reduction with empagliflozin. RESEARCH DESIGN AND METHODS: Effects of potential mediators, identified post hoc, on the HR for CV death with empagliflozin versus placebo were analyzed by Cox regression models, with treatment group adjusted for the baseline value of the variable and its change from baseline or updated mean (i...
December 4, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29203582/morning-enzymatic-activity-of-dpp-4-is-differentially-altered-by-sleep-loss-in-women-and-men
#7
LETTER
Frida H Rångtell, Felix Schmidt, Josefine Würfel, Swathy Karamchedu, Peter Andersson, Heike Vogel, Christian Benedict
No abstract text is available yet for this article.
December 4, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29196298/risk-assessment-in-patients-with-diabetes-with-the-timi-risk-score-for-atherothrombotic-disease
#8
Brian A Bergmark, Deepak L Bhatt, Eugene Braunwald, David A Morrow, Ph Gabriel Steg, Yared Gurmu, Avivit Cahn, Ofri Mosenzon, Itamar Raz, Erin Bohula, Benjamin M Scirica
OBJECTIVE: Improved risk assessment for patients with type 2 diabetes and elevated cardiovascular (CV) risk is needed. The TIMI Risk Score for Secondary Prevention (TRS 2°P) predicts a gradient of risk in patients with prior myocardial infarction (MI) but has not been evaluated in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: CV event rates were compared by baseline TRS 2°P in 16,488 patients enrolled in SAVOR-TIMI 53 with type 2 diabetes and high CV risk or established CV disease...
December 1, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29191845/revisiting-the-relationships-between-measures-of-glycemic-control-and-hypoglycemia-in-continuous-glucose-monitoring-datasets
#9
Marga Gimenez, Amitai Jeremy Tannen, Monika Reddy, Vanessa Moscardo, Ignacio Conget, Nick Oliver
OBJECTIVE: The Diabetes Control and Complications Trial identified an inverse relationship between HbA1c and severe hypoglycemia. We investigated the relationship between hypoglycemia and HbA1c in a large type 1 diabetes cohort on multiple daily injection or insulin pump therapy using blinded continuous glucose monitoring (CGM) data. The impact of real-time CGM on these relationships and how these relationships differ with biochemical definitions of hypoglycemia have also been assessed...
November 30, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29191844/reduction-in-hypoglycemia-with-the-predictive-low-glucose-management-system-a-long-term-randomized-controlled-trial-in-adolescents-with-type-1-diabetes
#10
Mary B Abraham, Jennifer A Nicholas, Grant J Smith, Janice M Fairchild, Bruce R King, Geoffrey R Ambler, Fergus J Cameron, Elizabeth A Davis, Timothy W Jones
OBJECTIVE: Short-term studies with automated systems that suspend basal insulin when hypoglycemia is predicted have shown a reduction in hypoglycemia; however, efficacy and safety have not been established in long-term trials. RESEARCH DESIGN AND METHODS: We conducted a 6-month, multicenter, randomized controlled trial in children and adolescents with type 1 diabetes using the Medtronic MiniMed 640G pump with Suspend before low (predictive low-glucose management [PLGM]) compared with sensor-augmented pump therapy (SAPT) alone...
November 30, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29187423/the-effect-of-telemedicine-follow-up-care-on-diabetes-related-foot-ulcers-a-cluster-randomized-controlled-noninferiority-trial
#11
Hilde Smith-Strøm, Jannicke Igland, Truls Østbye, Grethe S Tell, Marie F Hausken, Marit Graue, Svein Skeie, John G Cooper, Marjolein M Iversen
OBJECTIVE: To evaluate whether telemedicine (TM) follow-up of patients with diabetes-related foot ulcers (DFUs) in primary health care in collaboration with specialist health care was noninferior to standard outpatient care (SOC) for ulcer healing time. Further, we sought to evaluate whether the proportion of amputations, deaths, number of consultations per month, and patient satisfaction differed between the two groups. RESEARCH DESIGN AND METHODS: Patients with DFUs were recruited from three clinical sites in western Norway (2012-2016)...
November 29, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29183910/predictors-of-quality-of-life-and-other-patient-reported-outcomes-in-the-panorama-multinational-study-of-people-with-type-2-diabetes
#12
Clare Bradley, Eveline Eschwège, Pedro de Pablos-Velasco, Klaus G Parhofer, Dominique Simon, Hans Vandenberghe, Linda Gönder-Frederick
OBJECTIVE: PANORAMA, a nine-country cross-sectional type 2 diabetes study, investigated factors associated with quality of life (QoL), health status, and other patient-reported outcome measures (PROMs). RESEARCH DESIGN AND METHODS: Patients were randomly or consecutively selected from primary/secondary care. PROMs included the Audit of Diabetes-Dependent Quality of Life (ADDQoL) (generic QoL item and average weighted impact [AWI] scores), Diabetes Treatment Satisfaction Questionnaire (DTSQ) (patient- and physician-completed), Hypoglycemia Fear Survey-II worry subscale, and the EuroQoL-5 Dimension visual analog scale (EQ-VAS) measuring patient-reported health...
November 28, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29183909/comparison-of-%C3%AE-cell-function-between-overweight-obese-adults-and-adolescents-across-the-spectrum-of-glycemia
#13
Melinda E Chen, Aaditya G Chandramouli, Robert V Considine, Tamara S Hannon, Kieren J Mather
OBJECTIVE: Type 2 diabetes is a growing health problem among both adults and adolescents. To better understand the differences in the pathogenesis of diabetes between these groups, we examined differences in β-cell function along the spectrum of glucose tolerance. RESEARCH DESIGN AND METHODS: We evaluated 89 adults and 50 adolescents with normal glucose tolerance (NGT), dysglycemia, or type 2 diabetes (T2D). Oral glucose tolerance test results were used for C-peptide and insulin/glucose minimal modeling...
November 28, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29183908/modulation-of-glp-1-levels-by-a-genetic-variant-that-regulates-the-cardiovascular-effects-of-intensive-glycemic-control-in-accord
#14
Hetal S Shah, Mario Luca Morieri, Santica M Marcovina, Ronald J Sigal, Hertzel C Gerstein, Michael J Wagner, Alison A Motsinger-Reif, John B Buse, Peter Kraft, Josyf C Mychaleckyj, Alessandro Doria
OBJECTIVE: A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm. The aim of this study was to gain insights into the pathways involved in the modulatory effect of these variants...
November 28, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29180351/proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibitors-and-incident-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-with-over-96-000-patient-years
#15
Luiz Sérgio F de Carvalho, Alessandra M Campos, Andrei C Sposito
OBJECTIVE: Like mutations with loss of function in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene, inhibitors of PCSK9 (PCSK9i) may potentially favor the manifestation of diabetes. RESEARCH DESIGN AND METHODS: A meta-analysis of phase 2/3 randomized clinical trials (RCTs) assessed PCSK9i versus placebo in primary hypercholesterolemia setting. Statins and ezetimibe were used in 98.4% of these studies and balanced between PCSK9i and placebo. We calculated relative risks (RRs) and 95% CIs using random- and fixed-effect models...
November 27, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29167213/interaction-of-dietary-and-genetic-factors-influencing-body-iron-status-and-risk-of-type-2-diabetes-within-the-epic-interact-study
#16
Karina Meidtner, Clara Podmore, Janine Kröger, Yvonne T van der Schouw, Benedetta Bendinelli, Claudia Agnoli, Larraitz Arriola, Aurelio Barricarte, Heiner Boeing, Amanda J Cross, Courtney Dow, Kim Ekblom, Guy Fagherazzi, Paul W Franks, Marc J Gunter, José María Huerta, Paula Jakszyn, Mazda Jenab, Verena A Katzke, Timothy J Key, Kay Tee Khaw, Tilman Kühn, Cecilie Kyrø, Francesca Romana Mancini, Olle Melander, Peter M Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Ivonne Sluijs, Magdalena Stepien, Anne Tjonneland, Rosario Tumino, Nita G Forouhi, Stephen J Sharp, Claudia Langenberg, Matthias B Schulze, Elio Riboli, Nicholas J Wareham
OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries...
November 22, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29167212/cardiovascular-disease-cancer-and-mortality-among-people-with-type-2-diabetes-and-alcoholic-or-nonalcoholic-fatty-liver-disease-hospital-admission
#17
Sarah H Wild, Jeremy J Walker, Joanne R Morling, David A McAllister, Helen M Colhoun, Bassam Farran, Stuart McGurnaghan, Rory McCrimmon, Stephanie H Read, Naveed Sattar, Christopher D Byrne
OBJECTIVE: To describe associations between alcoholic liver disease (ALD) or nonalcoholic fatty liver disease (NAFLD) hospital admission and cardiovascular disease (CVD), cancer, and mortality in people with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a retrospective cohort study by using linked population-based routine data from diabetes registry, hospital, cancer, and death records for people ages 40-89 years diagnosed with T2DM in Scotland between 2004 and 2013 who had one or more hospital admission records...
November 22, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29158250/increased-liver-fatty-acid-uptake-is-partly-reversed-and-liver-fat-content-normalized-after-bariatric-surgery
#18
Heidi Immonen, Jarna C Hannukainen, Nobuyuki Kudomi, Jussi Pihlajamäki, Virva Saunavaara, Jukka Laine, Paulina Salminen, Terho Lehtimäki, Tam Pham, Patricia Iozzo, Pirjo Nuutila
OBJECTIVE: Changes in liver fatty acid metabolism are important in understanding the mechanisms of diabetes remission and metabolic changes after bariatric surgery. RESEARCH DESIGN AND METHODS: Liver fatty acid uptake (LFU), blood flow, and fat content (LFC) were measured in 25 obese subjects before bariatric surgery and 6 months after using positron emission tomography/computed tomography and MRS; 14 lean individuals served as the control subjects. RESULTS: The increased LFU in obese subjects was associated with body adiposity...
November 20, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29158249/objectively-measured-physical-activity-and-sedentary-time-are-associated-with-cardiometabolic-risk-factors-in-adults-with-prediabetes-the-preview-study
#19
Nils Swindell, Kelly Mackintosh, Melitta McNarry, Jeffrey W Stephens, Diewertje Sluik, Mikael Fogelholm, Mathijs Drummen, Ian MacDonald, J Alfredo Martinez, Teodora Handjieva-Darlenska, Sally D Poppitt, Jennie Brand-Miller, Thomas M Larsen, Anne Raben, Gareth Stratton
OBJECTIVE: The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS: Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m(-2) and impaired fasting glucose (5.6-6.9 mmol ⋅ L(-1)) or impaired glucose tolerance (7.8-11.0 mmol ⋅ L(-1) at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST...
November 20, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29150530/declining-rates-of-hospitalization-for-selected-cardiovascular-disease-conditions-among-adults-aged-%C3%A2-35-years-with-diagnosed-diabetes-u-s-1998-2014
#20
Nilka Ríos Burrows, YanFeng Li, Edward W Gregg, Linda S Geiss
OBJECTIVE: Reductions in heart attack and stroke hospitalizations are well documented in the U.S. population with diabetes. We extended trend analyses to other cardiovascular disease (CVD) conditions, including stroke by type, and used four additional years of data. RESEARCH DESIGN AND METHODS: Using 1998-2014 National (Nationwide) Inpatient Sample data, we estimated the number of discharges having acute coronary syndrome (ACS) (ICD-9 codes 410-411), cardiac dysrhythmia (427), heart failure (428), hemorrhagic stroke (430-432), or ischemic stroke (433...
November 17, 2017: Diabetes Care
journal
journal
20095
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"