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Diabetes Care

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https://www.readbyqxmd.com/read/27913576/empagliflozin-as-add-on-therapy-in-patients-with-type-2-diabetes-inadequately-controlled-with-linagliptin-and-metformin-a-24-week-randomized-double-blind-parallel-group-trial
#1
Eirik Søfteland, Juris J Meier, Bente Vangen, Robert Toorawa, Mario Maldonado-Lutomirsky, Uli C Broedl
OBJECTIVE: To evaluate the efficacy and safety of empagliflozin versus placebo as add-on therapy in patients with type 2 diabetes and inadequate glycemic control with linagliptin and metformin. RESEARCH DESIGN AND METHODS: Patients with HbA1c ≥8.0% and ≤10.5% (≥64 and ≤91 mmol/mol) while receiving stable-dose metformin received open-label linagliptin 5 mg (n = 606) for 16 weeks. Subsequently, those with HbA1c ≥7.0 and ≤10.5% (≥53 and ≤91 mmol/mol) were randomized to receive double-blind, double-dummy treatment with empagliflozin 10 mg (n = 112), empagliflozin 25 mg (n = 111), or placebo (n = 110) for 24 weeks; all patients continued treatment with metformin and linagliptin 5 mg...
December 2, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27913575/lowest-glucose-variability-and-hypoglycemia-are-observed-with-the-combination-of-a-glp-1-receptor-agonist-and-basal-insulin-variation-study
#2
Harpreet S Bajaj, Karri Venn, Chenglin Ye, Avril Patrick, Shivani Kalra, Hasnain Khandwala, Nadeem Aslam, David Twum-Barima, Ronnie Aronson
OBJECTIVE: There is a dearth of published literature comparing glucose variability (GV) between different insulin regimens in type 2 diabetes. This cohort study compares GV using continuous glucose monitoring (CGM) in patients with well-controlled type 2 diabetes using four common insulin regimens: basal insulin + oral drugs (BO), basal insulin + glucagon-like peptide 1 receptor agonist (GLP-1 RA) (BGLP), premixed insulin (PM), and basal-bolus insulin (BB). RESEARCH DESIGN AND METHODS: Consecutive patients from three endocrinology clinics who met study criteria-type 2 diabetes, age 18 to 80 years, BMI ≤ 45 kg/m(2), stable insulin regimen for a minimum of 6 months, and stable A1C value ≤7...
December 2, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27908920/extreme-insulin-resistance-from-insulin-antibodies-not-insulin-receptor-antibodies-successfully-treated-with-combination-immunosuppressive-therapy
#3
LETTER
Jennifer B Hao, Shahnawaz Imam, Pervaiz Dar, Maria Alfonso-Jaume, Noha Elnagar, Juan Carlos Jaume
No abstract text is available yet for this article.
December 1, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27903615/urine-proteome-specific-for-eye-damage-can-predict-kidney-damage-in-patients-with-type-2-diabetes-a-case-control-and-a-5-3-year-prospective-cohort-study
#4
Jin-Kui Yang, Ying-Ying Wang, Chang Liu, Ting-Ting Shi, Jing Lu, Xi Cao, Fang-Yuan Yang, Jian-Ping Feng, Chen Chen, Li-Nong Ji, Aimin Xu
OBJECTIVE: The predictive value of microalbuminuria (MAU) for kidney damage is limited in type 2 diabetes (T2D). We studied whether a urine proteome specific for sight-threatening proliferative diabetic retinopathy (PDR) is an indicator to predict chronic renal insufficiency (CRI) in patients with T2D. RESEARCH DESIGN AND METHODS: A shotgun urine proteomic analysis was performed in patients with MAU and PDR (case subjects) and in patients with MAU and a duration of T2D for >10 years but with without any degree of retinopathy (control subjects)...
November 30, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27903614/association-between-inpatient-sleep-loss-and-hyperglycemia-of-hospitalization
#5
Regina H DePietro, Kristen L Knutson, Lisa Spampinato, Samantha L Anderson, David O Meltzer, Eve Van Cauter, Vineet M Arora
OBJECTIVE: To determine whether inpatient sleep duration and efficiency are associated with a greater risk of hyperglycemia in hospitalized patients with and without diabetes. RESEARCH DESIGN AND METHODS: In this retrospective analysis of a prospective cohort study, medical inpatients ≥50 years of age were interviewed, and their charts were reviewed to obtain demographic data and diagnosis. Using World Health Organization criteria, patients were categorized as having normal blood glucose, impaired fasting blood glucose, or hyperglycemia based on morning glucose from the electronic health record...
November 30, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899499/differential-patterns-of-impaired-cardiorespiratory-fitness-and-cardiac-autonomic-dysfunction-in-recently-diagnosed-type-1-and-type-2-diabetes
#6
Martin Röhling, Alexander Strom, Gidon Bönhof, Sonja Püttgen, Kálmán Bódis, Karsten Müssig, Julia Szendrödi, Daniel Markgraf, Stefan Lehr, Michael Roden, Dan Ziegler
OBJECTIVE: Both impaired cardiorespiratory fitness (CRF) and heart rate variability (HRV) are predictors of mortality, but their relative roles in recent-onset diabetes are unknown. We determined to which extent CRF and HRV are reduced and interrelated in recent-onset diabetes. RESEARCH DESIGN AND METHODS: Participants from the German Diabetes Study with type 1 (n = 163) or type 2 (n = 188) diabetes with known diabetes duration <1 year and two age-matched glucose-tolerant control groups (n = 40 each) underwent spiroergometry and HRV assessment during a hyperinsulinemic-euglycemic clamp...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899498/association-of-visit-to-visit-variability-of-systolic-blood-pressure-with-cardiovascular-disease-and-mortality-in-primary-care-chinese-patients-with-type-2-diabetes-mellitus-a-retrospective-population-based-cohort-study
#7
Eric Yuk Fai Wan, Colman Siu Cheung Fung, Esther Yee Tak Yu, Daniel Yee Tak Fong, Julie Yun Chen, Cindy Lo Kuen Lam
OBJECTIVE: This study aimed to evaluate the impact of visit-to-visit variability (VVV) of systolic blood pressure (SBP) on cardiovascular disease (CVD) and mortality among primary care Chinese patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: A retrospective cohort study was conducted in 124,105 Chinese adult primary care patients with T2DM and without prior diagnosed CVD from August 2008 to December 2009. The VVV of SBP was evaluated using SDs of SBP over 24 months...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899497/the-effect-of-canagliflozin-a-sodium-glucose-cotransporter-2-inhibitor-on-glycemic-end-points-assessed-by-continuous-glucose-monitoring-and-patient-reported-outcomes-among-people-with-type-1-diabetes
#8
Helena W Rodbard, Anne L Peters, April Slee, Anjun Cao, Shana B Traina, Maria Alba
OBJECTIVE: To assess the effects of canagliflozin, a sodium glucose cotransporter 2 inhibitor, on glycemic parameters and measures of glucose variability assessed by a 9-point self-monitoring blood glucose (SMBG) and continuous glucose monitoring (CGM) profiles, and patient-reported outcomes as an add-on to insulin among participants with type 1 diabetes. RESEARCH DESIGN AND METHODS: In this randomized, double-blind study, 351 participants received canagliflozin 100 or 300 mg or placebo for 18 weeks...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899496/hormonal-contraception-and-risk-of-thromboembolism-in-women-with-diabetes
#9
Sarah H O'Brien, Terah Koch, Sara K Vesely, Eleanor Bimla Schwarz
OBJECTIVE: To investigate safety of hormonal contraception with regard to thromboembolic events in women with type 1 or 2 diabetes. RESEARCH DESIGN AND METHODS: We used data from 2002-2011 in Clinformatics Data Mart to identify women in the U.S., 14-44 years of age, with an ICD-9-CM code for diabetes and a prescription for a diabetic medication or device. We examined contraceptive claims and compared time to thromboembolism (venous thrombosis, stroke, or myocardial infarction) among women with diabetes dispensed hormonal contraception using a modification of Cox regression to control for age, smoking, obesity, hypertension, hyperlipidemia, diabetic complications, and history of cancer; we excluded data for 3 months after women gave birth...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899495/plantar-shear-stress-in-individuals-with-a-history-of-diabetic-foot-ulcer-an-emerging-predictive-marker-for-foot-ulceration
#10
LETTER
Metin Yavuz, Ali Ersen, Jessica Hartos, Brandy Schwarz, Alan G Garrett, Lawrence A Lavery, Dane K Wukich, Linda S Adams
No abstract text is available yet for this article.
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899494/incidence-trends-and-predictors-of-hospitalization-for-hypoglycemia-in-17-230-adult-patients-with-type-1-diabetes-a-danish-register-linkage-cohort-study
#11
Kazi Ishtiak-Ahmed, Bendix Carstensen, Ulrik Pedersen-Bjergaard, Marit E Jørgensen
OBJECTIVE: This study aimed to examine nationwide incidence trends and predictors of hospitalization for hypoglycemia (HH) in the adult population with type 1 diabetes in Denmark. RESEARCH DESIGN AND METHODS: All 17,230 patients with type 1 diabetes aged 16 years and above registered in the Danish Adult Diabetes Database (DADD) from 2006 were followed to 2012 by linkage of registers. Incidence rates of HH were modeled by Poisson regression by calendar time, taking sex, age, diabetes duration, clinical variables, and previous HH into account...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899493/screening-for-type-1-diabetes-thyroid-gastric-and-adrenal-specific-humoral-autoimmunity-in-529-children-and-adolescents-with-celiac-disease-at-diagnosis-identifies-as-positive-in-one-of-every-nine-patients
#12
LETTER
Claudio Tiberti, Monica Montuori, Francesca Panimolle, Chiara M Trovato, Caterina Anania, Francesco Valitutti, Anna R Vestri, Andrea Lenzi, Salvatore Cucchiara, Susanna Morano
No abstract text is available yet for this article.
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899492/extracorporeal-shockwave-therapy-improves-functional-outcomes-of-adhesive-capsulitis-of-the-shoulder-in-patients-with-diabetes
#13
LETTER
Flavia Santoboni, Stefano Balducci, Valeria D'Errico, Jonida Haxhi, Mario Vetrano, Giulia Piccinini, Andrea Ferretti, Giuseppe Pugliese, Maria Chiara Vulpiani
No abstract text is available yet for this article.
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899491/prevalence-of-diabetes-and-regional-differences-in-chinese-women-planning-pregnancy-a-nationwide-population-based-cross-sectional-study
#14
LETTER
Qiongjie Zhou, Qiaomei Wang, Haiping Shen, Yiping Zhang, Shikun Zhang, Xiaotian Li
No abstract text is available yet for this article.
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899490/carbohydrate-estimation-supported-by-the-gocarb-system-in-individuals-with-type-1-diabetes-a-randomized-prospective-pilot-study
#15
LETTER
Lia Bally, Joachim Dehais, Christos T Nakas, Marios Anthimopoulos, Markus Laimer, Daniel Rhyner, George Rosenberg, Thomas Zueger, Peter Diem, Stavroula Mougiakakou, Christoph Stettler
No abstract text is available yet for this article.
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899489/diabetes-device-use-in-adults-with-type-1-diabetes-barriers-to-uptake-and-potential-intervention-targets
#16
Molly L Tanenbaum, Sarah J Hanes, Kellee M Miller, Diana Naranjo, Rachel Bensen, Korey K Hood
OBJECTIVE: Diabetes devices (insulin pumps, continuous glucose monitors [CGMs]) are associated with benefits for glycemic control, yet uptake of these devices continues to be low. Some barriers to device uptake may be modifiable through psychosocial intervention, but little is known about which barriers and which patients to target. RESEARCH DESIGN AND METHODS: We surveyed 1,503 adult T1D Exchange participants (mean age 35.3 [SD 14.8] years, diagnosis duration 20...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899488/management-of-hemoglobin-variants-detected-incidentally-in-hba1c-testing-a-common-problem-currently-lacking-a-standard-approach
#17
LETTER
Michael R Lewis, Robert C Macauley, Patricia R Sheehan, Myrlene A Staten, Lawrence S Phillips, Neda Rasouli, Anastassios G Pittas
No abstract text is available yet for this article.
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27872155/glucose-concentrations-of-less-than-3-0-mmol-l-54-mg-dl-should-be-reported-in-clinical-trials-a-joint-position-statement-of-the-american-diabetes-association-and-the-european-association-for-the-study-of-diabetes
#18
https://www.readbyqxmd.com/read/27852664/long-term-protective-changes-in-adipose-tissue-after-gastric-bypass
#19
Johan Hoffstedt, Daniel P Andersson, Daniel Eriksson Hogling, Jakob Theorell, Erik Näslund, Anders Thorell, Anna Ehrlund, Mikael Rydén, Peter Arner
OBJECTIVE: Although long-term weight regain may occur after bariatric surgery, many patients are protected against relapse or development of type 2 diabetes. The study objective was to investigate whether this involves beneficial changes in adipose function. RESEARCH DESIGN AND METHODS: Forty-nine obese women were investigated before and 2 and 5 years after Roux-en-Y gastric bypass (RYGB). At the 5-year follow-up, 30 subjects were pairwise matched for BMI and age to 30 control women...
November 16, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27821407/role-of-type-2-diabetes-in-determining-retinal-renal-and-cardiovascular-outcomes-in-women-with-previous-gestational-diabetes-mellitus
#20
Ravi Retnakaran, Baiju R Shah
OBJECTIVE: Women who have gestational diabetes mellitus (GDM) have elevated lifetime risks for the development of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), compared with their peers. However, it is not known whether their risk of CVD is dependent upon the development of T2DM. Thus, we sought to evaluate the role of T2DM in determining vascular outcomes in women with previous GDM. RESEARCH DESIGN AND METHODS: All women in Ontario, Canada, with a live-birth pregnancy between April 1994 and March 2014 (n = 1,515,079) were stratified into the following four groups: women with GDM in whom T2DM subsequently developed (n = 15,585, median age 32 years); those with GDM in whom T2DM did not develop (n = 41,299; median age 32 years); women who did not have GDM but in whom T2DM developed (n = 49,397; median age 31 years); and those with neither GDM nor T2DM (n = 1,408,798; median age 30 years)...
November 7, 2016: Diabetes Care
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