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Diabetes Care

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https://www.readbyqxmd.com/read/30327364/plasma-lipidomic-profiling-and-risk-of-type-2-diabetes-in-the-predimed-trial
#1
Cristina Razquin, Estefanía Toledo, Clary B Clish, Miguel Ruiz-Canela, Courtney Dennis, Dolores Corella, Christopher Papandreou, Emilio Ros, Ramon Estruch, Marta Guasch-Ferré, Enrique Gómez-Gracia, Montserrat Fitó, Edward Yu, José Lapetra, Dong Wang, Dora Romaguera, Liming Liang, Angel Alonso-Gómez, Amy Deik, Mónica Bullo, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
OBJECTIVE: Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODS: We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327363/increased-prevalence-of-type-2-diabetes-related-complications-in-combined-type-2-diabetes-and-sickle-cell-trait
#2
Sarah C Skinner, Mor Diaw, Vincent Pialoux, Maïmouna Ndour Mbaye, Pauline Mury, Philomène Lopez, Delphine Bousquet, Fatou Gueye, Demba Diedhiou, Philippe Joly, Céline Renoux, Djiby Sow, Saliou Diop, Brigitte Ranque, Agnès Vinet, Abdoulaye Samb, Nicolas Guillot, Philippe Connes
OBJECTIVE: The prevalence of type 2 diabetes (T2D) is rapidly increasing in Sub-Saharan Africa, where sickle-cell trait (SCT) is also frequent. Although SCT is generally considered a benign condition, evidence suggests that SCT could exaggerate vascular dysfunction in T2D. However, it remains unclear whether SCT could increase the risk of the development of T2D complications. Therefore, this study was conducted to determine whether T2D complications were more prevalent among Senegalese individuals with SCT and T2D than among those with T2D only...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327362/pumps-or-multiple-daily-injections-in-pregnancy-involving-type-1-diabetes-a-prespecified-analysis-of-the-conceptt-randomized-trial
#3
Denice S Feig, Rosa Corcoy, Lois E Donovan, Kellie E Murphy, Jon F R Barrett, J Johanna Sanchez, Tim Wysocki, Katrina Ruedy, Craig Kollman, George Tomlinson, Helen R Murphy
OBJECTIVE: To compare glycemic control, quality of life, and pregnancy outcomes of women using insulin pumps and multiple daily injection therapy (MDI) during the Continuous Glucose Monitoring in Type 1 Diabetes Pregnancy Trial (CONCEPTT). RESEARCH DESIGN AND METHODS: This was a prespecified analysis of CONCEPTT involving 248 pregnant women from 31 centers. Randomization was stratified for pump versus MDI and HbA1c . The primary outcome was change in HbA1c from randomization to 34 weeks' gestation...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327361/individuals-fulfilling-criteria-for-type-2-diabetes-rather-than-lada-display-transient-signs-of-autoimmunity-preceding-diagnosis-with-possible-clinical-implications-the-hunt-study
#4
LETTER
Elin P Sørgjerd, Bjørn O Åsvold, Per M Thorsby, Valdemar Grill
No abstract text is available yet for this article.
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327360/associations-of-gestational-glucose-tolerance-with-offspring-body-composition-and-estimated-insulin-resistance-in-early-adolescence
#5
LETTER
Véronique Gingras, Sheryl L Rifas-Shiman, Ivonne P M Derks, Izzuddin M Aris, Emily Oken, Marie-France Hivert
No abstract text is available yet for this article.
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327359/area-deprivation-and-regional-disparities-in-treatment-and-outcome-quality-of-29-284-pediatric-patients-with-type-1-diabetes-in-germany-a-cross-sectional-multicenter-dpv-analysis
#6
Marie Auzanneau, Stefanie Lanzinger, Barbara Bohn, Peter Kroschwald, Ursula Kuhnle-Krahl, Paul Martin Holterhus, Kerstin Placzek, Johannes Hamann, Rainer Bachran, Joachim Rosenbauer, Werner Maier
OBJECTIVE: This study analyzed whether area deprivation is associated with disparities in health care of pediatric type 1 diabetes in Germany. RESEARCH DESIGN AND METHODS: We selected patients <20 years of age with type 1 diabetes and German residence documented in the "diabetes patient follow-up" (Diabetes-Patienten-Verlaufsdokumentation [DPV]) registry for 2015/16. Area deprivation was assessed by quintiles of the "German Index of Multiple Deprivation" (GIMD 2010) at the district level and was assigned to patients...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327358/prolonged-prothrombotic-effects-of-antecedent-hypoglycemia-in-individuals-with-type-2-diabetes
#7
Elaine Chow, Ahmed Iqbal, Emma Walkinshaw, Fladia Phoenix, Ian A Macdonald, Robert F Storey, Ramzi Ajjan, Simon R Heller
OBJECTIVE: Hypoglycemia has been linked to persistent increases in cardiovascular (CV) mortality in type 2 diabetes after the event. Our aim was to examine acute and downstream effects of hypoglycemia on markers of thrombosis risk and inflammation in type 2 diabetes. RESEARCH DESIGN AND METHODS: Twelve individuals with type 2 diabetes with no history of CV disease and 11 age- and BMI-matched volunteers without diabetes underwent paired hyperinsulinemic-euglycemic (glucose 6 mmol/L for two 60-min periods) and hypoglycemic (glucose 2...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327357/autoantibodies-to-the-ia-2-extracellular-domain-refine-the-definition-of-a-subtypes-of-ketosis-prone-diabetes
#8
Surya N Mulukutla, Maria Acevedo-Calado, Christiane S Hampe, Massimo Pietropaolo, Ashok Balasubramanyam
OBJECTIVE: Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the intracellular domain of IA-2. Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA), >60% of adults lack three classic islet autoantibodies-IA-2, GAD65, and ZnT8 Abs-associated with type 1 diabetes. We aimed to determine whether apparently autoantibody-negative ("A-") KPD patients possess occult IA-2 Ab directed against full-length IA-2 (IA-2FL) or its extracellular domain (IA-2EC)...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327356/prediabetes-is-associated-with-structural-brain-abnormalities-the-maastricht-study
#9
Marnix J M van Agtmaal, Alfons J H M Houben, Vera de Wit, Ronald M A Henry, Nicolaas C Schaper, Pieter C Dagnelie, Carla J van der Kallen, Annemarie Koster, Simone J Sep, Abraham A Kroon, Jacobus F A Jansen, Paul A Hofman, Walter H Backes, Miranda T Schram, Coen D A Stehouwer
OBJECTIVE: Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes are associated with lacunar infarcts (LIs), white matter hyperintensities (WMHs), cerebral microbleeds (CMBs), and brain atrophy. RESEARCH DESIGN AND METHODS: We used data from 2,228 participants (1,373 with normal glucose metabolism [NGM], 347 prediabetes, and 508 type 2 diabetes (oversampled); mean age 59...
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327355/recording-of-diabetes-on-death-certificates-of-decedents-with-type-1-diabetes-in-dcct-edic
#10
LETTER
Laura N McEwen, Pearl G Lee, Jye-Yu C Backlund, Catherine L Martin, William H Herman
No abstract text is available yet for this article.
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327354/ketone-body-infusion-increases-circulating-erythropoietin-and-bone-marrow-glucose-uptake
#11
LETTER
Katrine M Lauritsen, Esben Søndergaard, Mads Svart, Niels Møller, Lars C Gormsen
No abstract text is available yet for this article.
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30327353/maternal-antibiotic-use-during-pregnancy-and-type-1-diabetes-in-children-a-national-prospective-cohort-study
#12
LETTER
Martin Haupt-Jorgensen, Camilla S Morgen, Tine Jess, Karsten Buschard, Knud Josefsen, Kristine Højgaard Allin, Julie Christine Antvorskov
No abstract text is available yet for this article.
October 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305349/economic-costs-attributable-to-diabetes-in-each-u-s-state
#13
Sundar S Shrestha, Amanda A Honeycutt, Wenya Yang, Ping Zhang, Olga A Khavjou, Diana C Poehler, Simon J Neuwahl, Thomas J Hoerger
OBJECTIVE: To estimate direct medical and indirect costs attributable to diabetes in each U.S. state in total and per person with diabetes. RESEARCH DESIGN AND METHODS: We used an attributable fraction approach to estimate direct medical costs using data from the 2013 State Health Expenditure Accounts, 2013 Behavioral Risk Factor Surveillance System, and the Centers for Medicare & Medicaid Services' 2013-2014 Minimum Data Set. We used a human capital approach to estimate indirect costs measured by lost productivity from morbidity (absenteeism, presenteeism, lost household productivity, and inability to work) and premature mortality, using the 2008-2013 National Health Interview Survey, 2013 daily housework value data, 2013 mortality data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research, and mean wages from the 2014 Bureau of Labor Statistics...
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305348/increased-reporting-of-immune-checkpoint-inhibitor-associated-diabetes
#14
LETTER
Jordan J Wright, Joe-Elie Salem, Douglas B Johnson, Bénédicte Lebrun-Vignes, Angeliki Stamatouli, James W Thomas, Kevan C Herold, Javid Moslehi, Alvin C Powers
No abstract text is available yet for this article.
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305347/risk-factors-for-the-presence-and-progression-of-cardiovascular-autonomic-neuropathy-in-type-2-diabetes-addition-denmark
#15
Signe T Andersen, Daniel R Witte, Jesper Fleischer, Henning Andersen, Torsten Lauritzen, Marit E Jørgensen, Troels S Jensen, Rodica Pop-Busui, Morten Charles
OBJECTIVE: To examine the course of cardiovascular autonomic neuropathy (CAN) and related cardiometabolic risk factors in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: CAN and cardiometabolic risk factors were assessed in the Danish arm of the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen Detected Diabetes in Primary Care (ADDITION-Denmark) at 6-year ( n = 777) and 13-year ( n = 443) follow-up examinations. Cardiovascular autonomic reflex tests (CARTs)-that is, lying to standing, deep breathing, and the Valsalva maneuver-and 2-min resting heart rate variability (HRV) indices were obtained as the main measures of CAN...
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305346/first-look-at-control-iq-a-new-generation-automated-insulin-delivery-system
#16
Sue Brown, Dan Raghinaru, Emma Emory, Boris Kovatchev
OBJECTIVE: To pilot test a new closed-loop control technology to validate it for a further large clinical trial. RESEARCH DESIGN AND METHODS: The t:slim X2 insulin pump with Control-IQ Technology (Tandem Diabetes Care) includes a Dexcom G6 sensor and a closed-loop algorithm implemented in the pump that 1 ) automates insulin correction boluses, 2 ) has a dedicated hypoglycemia safety system, and 3 ) gradually intensifies control overnight, aiming for blood glucose levels of approximately 100-120 mg/dL every morning...
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305345/pharmacokinetics-pharmacodynamics-and-modulation-of-hepatic-glucose-production-with-insulin-glargine-u-300-and-glargine-u-100-at-steady-state-with-individualized-clinical-doses-in-type-1-diabetes
#17
Francesca Porcellati, Paola Lucidi, Paola Candeloro, Patrizia Cioli, Anna Marinelli Andreoli, Gianluca Curti, Geremia B Bolli, Carmine G Fanelli
OBJECTIVE: This study characterized the pharmacokinetics (PK), pharmacodynamics (PD), and endogenous (hepatic) glucose production (EGP) of clinical doses of glargine-U300 (Gla-300) and glargine-U100 (Gla-100) under steady-state conditions (SS) in type 1 diabetes mellitus (T1DM). RESEARCH DESIGN AND METHODS: T1DM subjects ( N = 18, age 40 ± 12 years, T1DM duration 26 ± 12 years, BMI 23.4 ± 2 kg/m2 , A1C 7.19 ± 0.52% [55 ± 5.7 mmol/mol]), were studied after 3 months of Gla-300 or Gla-100 (evening dosing) titrated to fasting euglycemia (random, crossover) with the euglycemic clamp using individualized doses (Gla-300 0...
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305344/fasting-glucose-variability-in-young-adulthood-and-cognitive-function-in-middle-age-the-coronary-artery-risk-development-in-young-adults-cardia-study
#18
Michael P Bancks, Mercedes R Carnethon, David R Jacobs, Lenore J Launer, Jared P Reis, Pamela J Schreiner, Ravi V Shah, Stephen Sidney, Kristine Yaffe, Yuichiro Yano, Norrina B Allen
OBJECTIVE: To determine whether intraindividual variability in fasting glucose (FG) below the threshold of diabetes is associated with cognitive function in middle adulthood beyond increasing FG. RESEARCH DESIGN AND METHODS: We studied 3,307 CARDIA (Coronary Artery Risk Development Study in Young Adults) participants (age range 18-30 years; 1985-1986) at baseline and calculated two measures of long-term glucose variability: the coefficient of variation about the mean FG (CV-FG) and the absolute difference between successive FG measurements [average real variability (ARV-FG)] before the onset of diabetes over 25 and 30 years of follow-up...
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30305343/efficacy-of-an-education-program-for-people-with-diabetes-and-insulin-pump-treatment-input-results-from-a-randomized-controlled-trial
#19
Dominic Ehrmann, Bernhard Kulzer, Melanie Schipfer, Bernhard Lippmann-Grob, Thomas Haak, Norbert Hermanns
OBJECTIVE: Continuous subcutaneous insulin infusion (CSII) is the most advanced form of insulin delivery, but it requires structured education to provide users with the necessary knowledge/skills and to support their motivation. Currently, no structured education program designed to provide this training has been evaluated. We developed a CSII-specific, structured education program (Insulin Pump Treatment [INPUT]) and evaluated its impact on glycemic control, behavior, and psychosocial status...
October 10, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30291106/management-of-hyperglycemia-in-type-2-diabetes-2018-a-consensus-report-by-the-american-diabetes-association-ada-and-the-european-association-for-the-study-of-diabetes-easd
#20
Melanie J Davies, David A D'Alessio, Judith Fradkin, Walter N Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J Wexler, John B Buse
The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in 2012 and 2015, on the management of type 2 diabetes in adults. A systematic evaluation of the literature since 2014 informed new recommendations. These include additional focus on lifestyle management and diabetes self-management education and support. For those with obesity, efforts targeting weight loss, including lifestyle, medication, and surgical interventions, are recommended...
October 4, 2018: Diabetes Care
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