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Diabetes Care

Lawrence A Leiter, Hwee Teoh, David Kallend, R Scott Wright, Ulf Landmesser, Peter L J Wijngaard, John J P Kastelein, Kausik K Ray
OBJECTIVE: To evaluate the efficacy and safety of inclisiran by diabetes status. RESEARCH DESIGN AND METHODS: ORION-1 (, NCT02597127) randomized 501 subjects with atherosclerotic cardiovascular disease (ASCVD) or ASCVD risk equivalents and high LDL cholesterol (LDL-C), despite maximally tolerated LDL-C-lowering therapies, to one or two doses of placebo or inclisiran. Levels of lipids and proprotein convertase subtilisin/kexin type 9 (PCSK9) at baseline and day 180 were compared...
November 28, 2018: Diabetes Care
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
OBJECTIVE: No study has been conducted to evaluate the association between avascular necrosis of the femoral head and diabetes. This study's aim was to assess this issue in Taiwan. RESEARCH DESIGN AND METHODS: A population-based cohort study was performed to analyze the database of Taiwan's National Health Insurance Program. There were 27,869 subjects aged 20-84 years with newly diagnosed diabetes from 2000 to 2012 as the group with diabetes. The group without diabetes included 111,476 sex- and age-matched subjects without diabetes...
November 28, 2018: Diabetes Care
Petter Bjornstad, Pattara Wiromrat, Richard J Johnson, Rachel Sippl, David Z Cherney, Randy Wong, Marian J Rewers, Janet K Snell-Bergeon
OBJECTIVE: Novel biomarkers are needed to better predict coronary artery calcification (CAC), a marker of subclinical atherosclerosis, and diabetic kidney disease (DKD) in type 1 diabetes. We evaluated the associations between serum uromodulin (SUMOD [a biomarker associated with anti-inflammatory and renal protective properties]), CAC progression and DKD development over 12 years. RESEARCH DESIGN AND METHODS: Participants ( n = 527, 53% females) in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study were examined during 2002-2004, at a mean age of 39...
November 27, 2018: Diabetes Care
Fukashi Ishibashi, Miki Taniguchi, Aiko Kosaka, Harumi Uetake, Mitra Tavakoli
OBJECTIVE: To investigate the impact of normalizing HbA1c by extensive HbA1c control (EHC) on neuropathy outcome measures (NOMs), nephropathy, and retinopathy in type 2 diabetes. RESEARCH DESIGN AND METHODS: Detailed clinical and neurological examinations were performed in two cohorts of 38 patients with uncontrolled type 2 diabetes patients (HbA1c 9.6% [81.4 mmol/mol]) at baseline and after glycemic control (GC) with or without EHC by diet restriction and hypoglycemic agents over 4 years along with 48 control subjects with normal glucose tolerance (NGT) and 34 subjects with impaired glucose tolerance (IGT) only at baseline...
November 19, 2018: Diabetes Care
Jolien Janssen, Esther van den Berg, Bernard Zinman, Mark A Espeland, Stefan L C Geijselaers, Michaela Mattheus, Odd Erik Johansen, Geert Jan Biessels
No abstract text is available yet for this article.
November 19, 2018: Diabetes Care
Ronnie Aronson, Ruth E Brown, Aihua Li, Michael C Riddell
OBJECTIVE: Postexercise hyperglycemia, following high-intensity interval training (HIIT) in patients with type 1 diabetes (T1D), is largely underrecognized by the clinical community and generally undertreated. The aim of this study was to compare four multipliers of an individual's insulin correction factor (ICF) to treat post-HIIT hyperglycemia. RESEARCH DESIGN AND METHODS: The FIT study had a randomized, crossover design in physically active subjects with T1D (mean ± SD age 34...
November 19, 2018: Diabetes Care
Stephen N Davis, William Duckworth, Nicholas Emanuele, Rodney A Hayward, Wyndy L Wiitala, Lizy Thottapurathu, Domenic J Reda, Peter D Reaven
OBJECTIVE: To determine the risk factors for severe hypoglycemia and the association between severe hypoglycemia and serious cardiovascular adverse events and cardiovascular and all-cause mortality in the Veterans Affairs Diabetes Trial (VADT). RESEARCH DESIGN AND METHODS: This post hoc analysis of data from the VADT included 1,791 military veterans (age 60.5 ± 9.0 years) with suboptimally controlled type 2 diabetes (HbA1c 9.4 ± 2.0%) of 11.5 ± 7.5 years disease duration with or without known cardiovascular disease and additional cardiovascular risk factors...
November 19, 2018: Diabetes Care
Joon Young Kim, Fida Bacha, Hala Tfayli, Sara F Michaliszyn, Shahwar Yousuf, Silva Arslanian
OBJECTIVE: Adipose tissue insulin resistance is one of the pathophysiological components of type 2 diabetes. Herein we investigated: 1 ) adipose insulin resistance index (Adipose-IR) (calculated as fasting insulin × free fatty acids [FFAs]) in youth across the spectrum of adiposity from normal weight to obese and the spectrum from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to type 2 diabetes, 2 ) the relationship of Adipose-IR with physical and metabolic characteristics, and 3 ) the predictive power of Adipose-IR for determining dysglycemia in youth...
November 19, 2018: Diabetes Care
Jan Skupien, Adam M Smiles, Erkka Valo, Tarunveer S Ahluwalia, Beata Gyorgy, Niina Sandholm, Stephanie Croall, Maria Lajer, Kevin McDonnell, Carol Forsblom, Valma Harjutsalo, Michel Marre, Andrzej T Galecki, David-Alexandre Tregouet, Chun Yi Wu, Josyf C Mychaleckyj, Helen Nickerson, Marlon Pragnell, Stephen S Rich, Marcus G Pezzolesi, Samy Hadjadj, Peter Rossing, Per-Henrik Groop, Andrzej S Krolewski
OBJECTIVE: Patients with type 1 diabetes and diabetic nephropathy are targets for intervention to reduce high risk of end-stage renal disease (ESRD) and deaths. This study compares risks of these outcomes in four international cohorts. RESEARCH DESIGN AND METHODS: In the 1990s and early 2000s, Caucasian patients with type 1 diabetes with persistent macroalbuminuria in chronic kidney disease stages 1-3 were identified in the Joslin Clinic (U.S., 432), Finnish Diabetic Nephropathy Study (FinnDiane) (Finland, 486), Steno Diabetes Center Copenhagen (Denmark, 368), and INSERM (France, 232) and were followed for 3-18 years with annual creatinine measurements to ascertain ESRD and deaths unrelated to ESRD...
November 19, 2018: Diabetes Care
Ryo Yoshinaga, Shizukiyo Ishikawa, Katsuhiko Ayukawa, Yasufumi Doi
No abstract text is available yet for this article.
November 19, 2018: Diabetes Care
Petra Zürbig, Harald Mischak, Jan Menne, Hermann Haller
No abstract text is available yet for this article.
November 19, 2018: Diabetes Care
Agata Juszczak, Tamara Pavić, Frano Vučković, Amanda J Bennett, Neha Shah, Edita Pape Medvidović, Christopher J Groves, Mario Šekerija, Kyla Chandler, Carla Burrows, Nataša Rojnić Putarek, Marijana Vučić Lovrenčić, Jadranka Ćuća Knežević, Tim J James, Anna L Gloyn, Gordan Lauc, Mark I McCarthy, Katharine R Owen, Olga Gornik
OBJECTIVE: Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the commonest type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker could improve selection of subjects for genetic testing and increase diagnosis rates. We previously reported that plasma levels of antennary fucosylated N -glycans and hs-CRP are reduced in individuals with HNF1A-MODY. In this study, we examined the potential use of N -glycans and hs-CRP in discriminating individuals with damaging HNF1A alleles from those without HNF1A variants in an unselected population of young adults with nonautoimmune diabetes...
November 19, 2018: Diabetes Care
Silva Arslanian, Laure El Ghormli, Joon Young Kim, Fida Bacha, Christine Chan, Heba M Ismail, Lorraine E Levitt Katz, Lynne Levitsky, Jeanie B Tryggestad, Neil H White
OBJECTIVE: Obese youth without diabetes with monophasic oral glucose tolerance test (OGTT) glucose-response curves have lower insulin sensitivity (IS) and impaired β-cell function compared with those with biphasic curves. The OGTT glucose response curve has not been studied in youth-onset type 2 diabetes. Here we test the hypothesis that the OGTT glucose response curve at randomization in youth in the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) study forecasts heightened glycemic failure rates and accelerated decline in β-cell function...
November 19, 2018: Diabetes Care
Simon Timpka, Jennifer J Stuart, Lauren J Tanz, Frank B Hu, Paul W Franks, Janet W Rich-Edwards
OBJECTIVE: To study the extent to which BMI after pregnancy adds to the elevated risk of postpregnancy type 2 diabetes in women with a history of hypertensive disorders of pregnancy (HDP) (preeclampsia or gestational hypertension). RESEARCH DESIGN AND METHODS: We used data from the Nurses' Health Study II, a prospective cohort study. In women aged 45-54 years without prior gestational diabetes mellitus, we investigated the interaction between BMI and HDP history on the risk of type 2 diabetes...
November 19, 2018: Diabetes Care
Wendy A Davis, Emma J Hamilton, David G Bruce, Timothy M E Davis
OBJECTIVE: To develop a type 2 diabetes hip fracture risk tool in community-based patients, to validate it in an independent cohort, and to compare its performance against the only published prediction equation to include type 2 diabetes as a risk factor (QFracture). RESEARCH DESIGN AND METHODS: Hip fracture hospitalizations in 1,251 participants with type 2 diabetes aged 40-89 years from the longitudinal Fremantle Diabetes Study Phase I (FDS1) were ascertained between entry (1993-1996) and end-2012...
November 19, 2018: Diabetes Care
Sundar S Shrestha, Ping Zhang, Israel Hora, Linda S Geiss, Elizabeth T Luman, Edward W Gregg
OBJECTIVE: To examine changes in diabetes-related preventable hospitalization costs and to determine the contribution of each underlying factor to these changes. RESEARCH DESIGN AND METHODS: We used data from the 2001-2014 U.S. National Inpatient Sample for adults (≥18 years old) to estimate the trends in hospitalization costs (2014 USD) in total and by condition (short-term complications, long-term complications, uncontrolled diabetes, and lower-extremity amputation)...
November 19, 2018: Diabetes Care
Sundar S Shrestha, Ping Zhang, Israel A Hora, Edward W Gregg
OBJECTIVE: We assessed the excess medical expenditures for adults newly diagnosed with diabetes, for up to 10 years before and after diabetes diagnosis. RESEARCH DESIGN AND METHODS: Using the 2001-2013 MarketScan data, we identified people with newly diagnosed diabetes among adults aged 25-64 years (diabetes cohort) and matched them with people who did not have diagnosed diabetes (control cohort) using 1:1 propensity score matching. We followed these two cohorts up to ±10 years from the index date, with annual matched cohort sizes ranging from 3,922 to 39,726 individuals...
November 19, 2018: Diabetes Care
Tali Cukierman-Yaffe, Jackie Bosch, Hyejung Jung, Zubin Punthakee, Hertzel C Gerstein
OBJECTIVE: Epidemiological studies have reported a relationship between severe hypoglycemia, cognitive dysfunction, and dementia in middle-aged and older people with type 2 diabetes. However, whether severe or nonsevere hypoglycemia precedes cognitive dysfunction is unclear. Thus, the aim of this study was to analyze the relationship between hypoglycemia and incident cognitive dysfunction in a group of carefully followed patients using prospectively collected data in the Outcome Reduction with Initial Glargine Intervention (ORIGIN trial)...
November 13, 2018: Diabetes Care
Min Zhao, Abel López-Bermejo, Carmelo A Caserta, Carla Campos Muniz Medeiros, Anastasios Kollias, Judit Bassols, Elisabetta L Romeo, Thacira Dantas Almeida Ramos, George S Stergiou, Lili Yang, Silvia Xargay-Torrent, Angela Amante, Tatianne Moura Estrela Gusmão, Evangelos Grammatikos, Yuanyuan Zhang, Anna Prats-Puig, Danielle Franklin de Carvalho, Liu Yang, Gemma Carreras-Badosa, Mônica de Oliveira Simões, Yaping Hou, Berta Mas-Pares, Wang Shui, Teng Guo, Mingming Wang, Hua Chen, Xiaohuan Lou, Qian Zhang, Yanqing Zhang, Pascal Bovet, Costan G Magnussen, Bo Xi
OBJECTIVE: It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy of CVD risk, in children and adolescents. RESEARCH DESIGN AND METHODS: Data were available for 3,497 children and adolescents aged 6-17 years from five population-based cross-sectional studies in Brazil, China, Greece, Italy, and Spain. Weight status categories (normal, overweight, and obese) were defined using BMI cutoffs from the International Obesity Task Force...
November 12, 2018: Diabetes Care
Linda S Geiss, Yanfeng Li, Israel Hora, Ann Albright, Deborah Rolka, Edward W Gregg
OBJECTIVES: To determine whether declining trends in lower extremity amputations have continued into the current decade. RESEARCH DESIGN AND METHODS: We calculated hospitalization rates for nontraumatic lower extremity amputation (NLEA) for the years 2000-2015 using nationally representative, serial cross-sectional data from the Nationwide Inpatient Sample on NLEA procedures and from the National Health Interview Survey for estimates of the populations with and without diabetes...
November 8, 2018: Diabetes Care
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