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Diabetes Care

Patricia Lucia Casavalle, Fima Lifshitz, Laura S Romano, Maria Macarena Gonzalez Chaves, Noemí Bordoni, Patricia Mónica Boyer, Patricia Noemi Rodriguez, Silvia Maria Friedman
No abstract text is available yet for this article.
October 14, 2016: Diabetes Care
Jan H Cornel, George L Bakris, Susanna R Stevens, Michael Alvarsson, Willem A Bax, Lee-Ming Chuang, Samuel S Engel, Renato D Lopes, Darren K McGuire, Axel Riefflin, Helena Wachslicht Rodbard, Isaac Sinay, Tsvetalina Tankova, Julio Wainstein, Eric D Peterson, Rury R Holman
OBJECTIVE: To evaluate chronic kidney disease (CKD) and cardiovascular outcomes in TECOS (Clinical trial reg. no. NCT00790205, participants with type 2 diabetes and cardiovascular disease treated with sitagliptin, a dipeptidyl peptidase 4 inhibitor, according to baseline estimated glomerular filtration rate (eGFR). RESEARCH DESIGN AND METHODS: We used data from 14,671 TECOS participants assigned in a double-blind design to receive sitagliptin or placebo added to existing therapy, while aiming for glycemic equipoise between groups...
October 14, 2016: Diabetes Care
Deanna J M Isaman, Amy E Rothberg, William H Herman
OBJECTIVE: Bariatric surgery may induce remission of type 2 diabetes in obese patients. However, estimates of remission rates reported in the literature range from 25 to 81%, contributing to the uncertainty patients and physicians both face as they assess treatment options. This analysis attempts to reconcile the seemingly disparate rates of diabetes remission reported in studies of Roux-en-Y gastric bypass (RYGB) surgery. It examines variation in the methodologies used to derive the estimates and proposes outcomes that should be reported by all studies...
October 13, 2016: Diabetes Care
Gilad Twig, Amir Tirosh, Adi Leiba, Hagai Levine, Dana Ben-Ami Shor, Estela Derazne, Ziona Haklai, Nehama Goldberger, Michal Kasher-Meron, Dror Yifrach, Hertzel C Gerstein, Jeremy D Kark
OBJECTIVE: The sequelae of increasing childhood obesity are of major concern. We assessed the association of BMI in late adolescence with diabetes mortality in midlife. RESEARCH DESIGN AND METHODS: The BMI values of 2,294,139 Israeli adolescents (age 17.4 ± 0.3 years), measured between 1967 and 2010, were grouped by US Centers for Disease Control and Prevention age/sex percentiles and by ordinary BMI values. The outcome, obtained by linkage with official national records, was death attributed to diabetes mellitus (DM) as the underlying cause...
October 12, 2016: Diabetes Care
Mary de Groot, Kent A Crick, Molly Long, Chandan Saha, Jay H Shubrook
OBJECTIVE: Depression in patients with type 2 diabetes (T2D) is associated with long-term complications, disability, and early mortality. No studies have systematically examined the length of episodes and remission in adults with major depressive disorder (MDD) and T2D. This study examined the course of depressive disorders in patients with T2D and MDD. RESEARCH DESIGN AND METHODS: Participants (N = 50) enrolled in a behavioral intervention for adults with T2D and MDD were interviewed using the Structured Clinical Interview for DSM-IV-TR to assess history of depressive disorders at baseline (lifetime history), postintervention, and 3-month follow-up...
October 11, 2016: Diabetes Care
Susan M Sereika, Dorothy Becker, Patricia Schmitt, A Blair Powell, Ana Maria Diaz, Andrea F R Fischl, Jennifer Thurheimer-Cacciotti, William H Herman, Denise Charron-Prochownik
OBJECTIVE: Because unplanned pregnancies could cause maternal-fetal complications for women with diabetes, family planning vigilance (FPV) is imperative. The aims of this article are to operationalize and describe FPV and examine the associations among FPV behaviors and diabetes self-care management (DSM) and health outcomes of women with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: Retrospective data were used from a follow-up study of adult women with T1D who participated as adolescents in a preconception counseling (PC) intervention trial and matched comparison women with T1D who did not receive the adolescent PC intervention...
October 11, 2016: Diabetes Care
Gilberto Velho, Ray El Boustany, Guillaume Lefèvre, Kamel Mohammedi, Frédéric Fumeron, Louis Potier, Lise Bankir, Nadine Bouby, Samy Hadjadj, Michel Marre, Ronan Roussel
OBJECTIVE: Plasma copeptin, a surrogate for vasopressin, has been associated with a decline in renal function and albuminuria in population-based studies as well as with progression of diabetic nephropathy in people with type 2 diabetes. We assessed the risk of kidney and coronary events and all-cause mortality associated with plasma copeptin in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: Plasma copeptin was measured in baseline samples of the GENEDIAB (n = 398; 56% male; mean ± SD age 45 ± 12 years and diabetes duration 28 ± 10 years) and GENESIS (n = 588; 52% male; age 42 ± 11 years; diabetes duration 27 ± 9 years) cohorts...
October 11, 2016: Diabetes Care
Nicholette D Palmer Allred, Laura M Raffield, Joycelyn C Hardy, Fang-Chi Hsu, Jasmin Divers, Jianzhao Xu, S Carrie Smith, Christina E Hugenschmidt, Benjamin C Wagner, Christopher T Whitlow, Kaycee M Sink, Joseph A Maldjian, Jeff D Williamson, Donald W Bowden, Barry I Freedman
OBJECTIVE: Dementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D. RESEARCH DESIGN AND METHODS: European Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)- DHS MIND (n = 517) were examined...
October 4, 2016: Diabetes Care
Jennifer L Sherr, Claire T Boyle, Kellee M Miller, Roy W Beck, William V Tamborlane
No abstract text is available yet for this article.
October 4, 2016: Diabetes Care
Elizabeth A C Sellers, Heather J Dean, Leigh Anne Shafer, Patricia J Martens, Wanda Phillips-Beck, Maureen Heaman, Heather J Prior, Allison B Dart, Jonathan McGavock, Margaret Morris, Ali A Torshizi, Sora Ludwig, Garry X Shen
OBJECTIVE: Type 2 diabetes is increasing in children worldwide, with Canadian First Nation (FN) children disproportionally affected. The prevalence of gestational diabetes mellitus (GDM) also is increasing. The objective of this study was to evaluate the impact of GDM exposure in utero and FN status on the subsequent risk of type 2 diabetes in offspring in the first 30 years of life. RESEARCH DESIGN AND METHODS: In this population-based historical prospective cohort study, we used administrative databases linked to a clinical database to explore the independent association and interaction between GDM and FN status on the subsequent development of type 2 diabetes in offspring...
October 4, 2016: Diabetes Care
Liangjian Lu, Albert Koulman, Clive J Petry, Benjamin Jenkins, Lee Matthews, Ieuan A Hughes, Carlo L Acerini, Ken K Ong, David B Dunger
OBJECTIVE: To investigate the relationship between early second trimester serum lipidomic variation and maternal glycemic traits at 28 weeks, and to identify predictive lipid biomarkers for gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: Prospective study of 817 pregnant women (discovery cohort, n = 200; validation cohort, n = 617) who provided an early second trimester serum sample, and underwent an oral glucose tolerance test (OGTT) at 28 weeks...
October 4, 2016: Diabetes Care
Giuseppina T Russo, Salvatore De Cosmo, Francesca Viazzi, Antonio Pacilli, Antonio Ceriello, Stefano Genovese, Pietro Guida, Carlo Giorda, Domenico Cucinotta, Roberto Pontremoli, Paola Fioretto
OBJECTIVE: Despite the achievement of blood glucose, blood pressure, and LDL-cholesterol (LDL-C) targets, the risk for diabetic kidney disease (DKD) remains high among patients with type 2 diabetes. This observational retrospective study investigated whether diabetic dyslipidemia-that is, high triglyceride (TG) and/or low HDL-cholesterol (HDL-C) levels-contributes to this high residual risk for DKD. RESEARCH DESIGN AND METHODS: Among a total of 47,177 patients attending Italian diabetes centers, 15,362 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1...
October 4, 2016: Diabetes Care
Subodh Verma, Ankit Garg, Andrew T Yan, Anup K Gupta, Mohammed Al-Omran, Andre Sabongui, Hwee Teoh, C David Mazer, Kim A Connelly
No abstract text is available yet for this article.
September 27, 2016: Diabetes Care
Kamel Mohammedi, Mark Woodward, Sophia Zoungas, Qiang Li, Stephen Harrap, Anushka Patel, Michel Marre, John Chalmers
OBJECTIVE: The burden of vascular diseases remains substantial in patients with type 2 diabetes, requiring identification of further risk markers. We tested the absence of dorsalis pedis and posterior tibial pulses as predictors of major macrovascular and microvascular events, death, and cognitive decline in this population. RESEARCH DESIGN AND METHODS: Data were derived from 11,120 patients with type 2 diabetes in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) study...
September 27, 2016: Diabetes Care
Kasia J Lipska, Xiaoxi Yao, Jeph Herrin, Rozalina G McCoy, Joseph S Ross, Michael A Steinman, Silvio E Inzucchi, Thomas M Gill, Harlan M Krumholz, Nilay D Shah
OBJECTIVE: To examine temporal trends in utilization of glucose-lowering medications, glycemic control, and rate of severe hypoglycemia among patients with type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS: Using claims data from 1.66 million privately insured and Medicare Advantage patients with T2DM from 2006 to 2013, we estimated the annual 1) age- and sex-standardized proportion of patients who filled each class of agents; 2) age-, sex-, race-, and region-standardized proportion with hemoglobin A1c (HbA1c) <6%, 6 to <7%, 7 to <8%, 8 to <9%, ≥9%; and 3) age- and sex-standardized rate of severe hypoglycemia among those using medications...
September 22, 2016: Diabetes Care
Ivan Tkáč, Itamar Raz
OBJECTIVE: Data on the possible relationship of gliptin treatment to the incidence of acute pancreatitis have been controversial. The aim of the current study was to combine data on the incidence of acute pancreatitis from three large randomized controlled trials. RESEARCH DESIGN AND METHODS: Three trials designed to test cardiovascular safety and efficacy of add-on treatment with a gliptin were included in the analysis, as follows: SAVOR-TIMI 53 (saxagliptin), EXAMINE (alogliptin), and TECOS (sitagliptin)...
September 22, 2016: Diabetes Care
Rachel G Miller, Hemant D Mahajan, Tina Costacou, Akira Sekikawa, Stewart J Anderson, Trevor J Orchard
OBJECTIVE: The degree to which mortality and cardiovascular disease (CVD) incidence remains elevated in young U.S. adults with type 1 diabetes (T1DM) is unclear. We determined contemporary rates for adults <45 years old with long-standing, childhood-onset T1DM from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. RESEARCH DESIGN AND METHODS: Members of the EDC Study cohort <45 years old during the 1996-2012 follow-up period (n = 502) were studied...
September 21, 2016: Diabetes Care
Eduardo Peixoto, Francesco Vendrame, Alvaro Arnau, Nathalia Padilla, David Baidal, Ana Alvarez, Valentina Delmonte, Alessia Fornoni, Camillo Ricordi, Rodolfo Alejandro
No abstract text is available yet for this article.
September 20, 2016: Diabetes Care
Vanita R Aroda, Julio Rosenstock, Carol Wysham, Jeffrey Unger, Diego Bellido, Guillermo González-Gálvez, Akane Takami, Hailing Guo, Elisabeth Niemoeller, Elisabeth Souhami, Richard M Bergenstal
OBJECTIVE: This study was conducted to demonstrate the efficacy and safety of LixiLan (iGlarLixi), a novel, titratable, fixed-ratio combination of insulin glargine (iGlar) (100 units) and lixisenatide, compared with iGlar in patients with type 2 diabetes inadequately controlled on basal insulin with or without up to two oral glucose-lowering agents. RESEARCH DESIGN AND METHODS: After a 6-week run-in when iGlar was introduced and/or further titrated, and oral antidiabetic drugs other than metformin were stopped, 736 basal insulin-treated patients (mean diabetes duration 12 years, BMI 31 kg/m(2)) were randomized 1:1 to open-label, once-daily iGlarLixi or iGlar, both titrated to fasting plasma glucose <100 mg/dL (<5...
September 20, 2016: Diabetes Care
Jan Skupien, James H Warram, Adam M Smiles, Robert C Stanton, Andrzej S Krolewski
OBJECTIVE: The patterns of estimated glomerular filtration rate (eGFR) decline to end-stage renal disease (ESRD) in patients with type 1 diabetes has not been conclusively described. Decline could be linearly progressive to ESRD but with a variable rate. Conversely, decline may be linear but interrupted by periods of plateaus or improvements. RESEARCH DESIGN AND METHODS: This observational study included 364 patients with type 1 diabetes attending Joslin Clinic who developed ESRD between 1991 and 2013...
September 19, 2016: Diabetes Care
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