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Diabetes Care

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https://www.readbyqxmd.com/read/28550195/dipeptidyl-peptidase-4-inhibition-stimulates-distal-tubular-natriuresis-and-increases-in-circulating-sdf-1%C3%AE-1-67-in-patients-with-type-2-diabetes
#1
Julie A Lovshin, Harindra Rajasekeran, Yulyia Lytvyn, Leif E Lovblom, Shajiha Khan, Robel Alemu, Amy Locke, Vesta Lai, Huaibing He, Lucinda Hittle, Weixun Wang, Daniel J Drucker, David Z I Cherney
OBJECTIVE: Antihyperglycemic agents, such as empagliflozin, stimulate proximal tubular natriuresis and improve cardiovascular and renal outcomes in patients with type 2 diabetes. Because dipeptidyl peptidase 4 (DPP-4) inhibitors are used in combination with sodium-glucose cotransporter 2 (SGLT-2) inhibitors, we examined whether and how sitagliptin modulates fractional sodium excretion and renal and systemic hemodynamic function. RESEARCH DESIGN AND METHODS: We studied 32 patients with type 2 diabetes in a prospective, double-blind, randomized, placebo-controlled trial...
May 26, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28550194/the-risk-of-severe-hypoglycemia-in-type-1-diabetes-over-30-years-of-follow-up-in-the-dcct-edic-study
#2
Rose A Gubitosi-Klug, Barbara H Braffett, Neil H White, Robert S Sherwin, F John Service, John M Lachin, William V Tamborlane
OBJECTIVE: During the DCCT, intensive diabetes therapy achieving a mean HbA1c of ∼7% was associated with a threefold increase in the rate of severe hypoglycemia (defined as requiring assistance) compared with conventional diabetes therapy with a mean HbA1c of 9% (61.2 vs. 18.7 per 100 patient-years). After ∼30 years of follow-up, we investigated the rates of severe hypoglycemia in the DCCT/EDIC cohort. RESEARCH DESIGN AND METHODS: Rates of severe hypoglycemia were reported quarterly during DCCT and annually during EDIC (i...
May 26, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28546222/prevalence-of-celiac-disease-in-52-721-youth-with-type-1-diabetes-international-comparison-across-three-continents
#3
Maria E Craig, Nicole Prinz, Claire T Boyle, Fiona M Campbell, Timothy W Jones, Sabine E Hofer, Jill H Simmons, Naomi Holman, Elaine Tham, Elke Fröhlich-Reiterer, Stephanie DuBose, Helen Thornton, Bruce King, David M Maahs, Reinhard W Holl, Justin T Warner
OBJECTIVE: Celiac disease (CD) has a recognized association with type 1 diabetes. We examined international differences in CD prevalence and clinical characteristics of youth with coexisting type 1 diabetes and CD versus type 1 diabetes only. RESEARCH DESIGN AND METHODS: Data sources were as follows: the Prospective Diabetes Follow-up registry (Germany/Austria); the T1D Exchange Clinic Network (T1DX) (U.S.); the National Paediatric Diabetes Audit (U.K. [England/Wales]); and the Australasian Diabetes Data Network (ADDN) (Australia)...
May 25, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28546221/factors-associated-with-diabetes-specific-health-related-quality-of-life-in-youth-with-type-1-diabetes-the-global-teens-study
#4
Barbara J Anderson, Lori M Laffel, Catherine Domenger, Thomas Danne, Moshe Phillip, Carmen Mazza, Ragnar Hanas, Sheridan Waldron, Roy W Beck, Francoise Calvi-Gries, Chantal Mathieu
OBJECTIVE: Our objective was to characterize diabetes-specific health-related quality of life (D-HRQOL) in a global sample of youth and young adults with type 1 diabetes (T1D) and to identify the main factors associated with quality of life. RESEARCH DESIGN AND METHODS: The TEENs study was an international, cross-sectional study of youth, 8-25 years of age, with T1D. Participants (N = 5,887) were seen in clinical sites in 20 countries across 5 continents enrolled for 3 predetermined age groups: 8-12, 13-18, and 19-25 years of age...
May 25, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28522558/erratum-pharmacologic-approaches-to-glycemic-treatment-sec-8-in-standards-of-medical-care-in-diabetes-2017-diabetes-care-2017-40-suppl-1-s64-s74
#5
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28522557/erratum-glycemic-targets-sec-6-in-standards-of-medical-care-in-diabetes-2017-diabetes-care-2017-40-suppl-1-s48-s56
#6
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28522556/erratum-diabetes-care-in-the-hospital-sec-14-in-standards-of-medical-care-in-diabetes-2017-diabetes-care-2017-40-suppl-1-s120-s127
#7
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28522555/erratum-comprehensive-medical-evaluation-and-assessment-of-comorbidities-sec-3-in-standards-of-medical-care-in-diabetes-2017-diabetes-care-2017-40-suppl-1-s25-s32
#8
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28522554/erratum-microvascular-complications-and-foot-care-sec-10-in-standards-of-medical-care-in-diabetes-2017-diabetes-care-2017-40-suppl-1-s88-s98
#9
(no author information available yet)
No abstract text is available yet for this article.
May 18, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28515131/exenatide-improves-hdl-particle-counts-and-size-distribution-in-patients-with-long-standing-type-1-diabetes
#10
LETTER
Evgenia A Gourgari, Mihriye Mete, Maureen L Sampson, David M Harlan, Alan T Remaley, Kristina I Rother
No abstract text is available yet for this article.
May 17, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28507023/increases-in-biomarkers-of-hyperglycemia-with-age-in-the-atherosclerosis-risk-in-communities-aric-study
#11
LETTER
Bethany Warren, Andreea M Rawlings, Alexandra K Lee, Morgan Grams, Josef Coresh, Elizabeth Selvin
No abstract text is available yet for this article.
May 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28500217/glucose-peaks-and-the-risk-of-dementia-and-20-year-cognitive-decline
#12
Andreea M Rawlings, A Richey Sharrett, Thomas H Mosley, Shoshana H Ballew, Jennifer A Deal, Elizabeth Selvin
OBJECTIVE: Hemoglobin A1c (HbA1c), a measure of average blood glucose level, is associated with the risk of dementia and cognitive impairment. However, the role of glycemic variability or glucose excursions in this association is unclear. We examined the association of glucose peaks in midlife, as determined by the measurement of 1,5-anhydroglucitol (1,5-AG) level, with the risk of dementia and 20-year cognitive decline. RESEARCH DESIGN AND METHODS: Nearly 13,000 participants from the Atherosclerosis Risk in Communities (ARIC) study were examined...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28500216/metformin-lifestyle-intervention-and-cognition-in-the-diabetes-prevention-program-outcomes-study
#13
José A Luchsinger, Yong Ma, Costas A Christophi, Hermes Florez, Sherita H Golden, Helen Hazuda, Jill Crandall, Elizabeth Venditti, Karol Watson, Susan Jeffries, Jennifer J Manly, F Xavier Pi-Sunyer
OBJECTIVE: We examined the association of the Diabetes Prevention Program (DPP) intervention arms (lifestyle intervention, metformin, and placebo) with cognition in the DPP Outcomes Study (DPPOS). We also examined metformin use, incident type 2 diabetes, and glycemia as exposures. RESEARCH DESIGN AND METHODS: The DPP lasted 2.8 years, followed by a 13-month bridge to DPPOS. Cognition was assessed in DPPOS years 8 and 10 (12 and 14 years after randomization) with the Spanish English Verbal Learning Test (SEVLT), letter fluency and animal fluency tests, Digit Symbol Substitution Test (DSST), and a composite cognitive score...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28500215/a-national-effort-to-prevent-type-2-diabetes-participant-level-evaluation-of-cdc-s-national-diabetes-prevention-program
#14
Elizabeth K Ely, Stephanie M Gruss, Elizabeth T Luman, Edward W Gregg, Mohammed K Ali, Kunthea Nhim, Deborah B Rolka, Ann L Albright
OBJECTIVE: To assess participant-level results from the first 4 years of implementation of the National Diabetes Prevention Program (National DPP), a national effort to prevent type 2 diabetes in those at risk through structured lifestyle change programs. RESEARCH DESIGN AND METHODS: Descriptive analysis was performed on data from 14,747 adults enrolled in year-long type 2 diabetes prevention programs during the period February 2012 through January 2016. Data on attendance, weight, and physical activity minutes were summarized and predictors of weight loss were examined using a mixed linear model...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28500214/efficacy-of-the-telemedical-lifestyle-intervention-program-telipro-in-advanced-stages-of-type-2-diabetes-a-randomized-controlled-trial
#15
Kerstin Kempf, Bernd Altpeter, Janine Berger, Oliver Reuß, Matthias Fuchs, Michael Schneider, Babette Gärtner, Katja Niedermeier, Stephan Martin
OBJECTIVE: Lifestyle interventions are the foundation of treatment in newly diagnosed type 2 diabetes. However, their therapeutic potential in advanced disease stages is unknown. We evaluated the efficacy of the Telemedical Lifestyle intervention Program (TeLiPro) in improving metabolic control in advanced-stage type 2 diabetes. RESEARCH DESIGN AND METHODS: In this single-blind, active comparator, intervention study, patients with type 2 diabetes (with glycated hemoglobin [HbA1c] ≥7...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28495903/health-care-service-and-outcomes-among-an-estimated-6-7-million-ambulatory-care-diabetic-foot-cases-in-the-u-s
#16
Grant H Skrepnek, Joseph L Mills, Lawrence A Lavery, David G Armstrong
OBJECTIVE: To evaluate ambulatory clinical cases of diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) in the U.S. from 2007 to 2013 and to assess outcomes of emergency department or inpatient (ED/IP) admission, number of clinic visits per year, and physician time spent per visit. RESEARCH DESIGN AND METHODS: A cross-sectional historical cohort analysis was conducted by using the nationally representative Centers for Disease Control and Prevention National Ambulatory Medical Care Survey data from 2007 to 2013, including patients age ≥18 years with diabetes and either DFIs or DFUs...
May 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28490423/declining-trends-of-cardiovascular-renal-complications-and-mortality-in-type-2-diabetes-the-hong-kong-diabetes-database
#17
Andrea O Y Luk, Eric M T Hui, Ming-Chuen Sin, Chun-Yip Yeung, Wing-Sun Chow, Andrew Y Y Ho, Hin-Fai Hung, Eva Kan, Chiu-Ming Ng, Wing-Yee So, Chi-Kin Yeung, Kin-Sang Chan, Kin-Wah Chan, Pang-Fai Chan, Shing-Chung Siu, Sau-Cheung Tiu, Vincent T F Yeung, Juliana C N Chan, Frank W K Chan, Clement Cheung, Ngai-Tseung Cheung, Siu-Tung Ho, Karen S L Lam, Linda W L Yu, David Chao, Ip-Tim Lau
OBJECTIVE: Nationwide studies on secular trends of diabetes complications are not available in Asia. We examined changes in risk factor control and incidence of complications from diabetes and death in a large longitudinal cohort of Chinese adults with type 2 diabetes in Hong Kong. RESEARCH DESIGN AND METHODS: Between 1 January 2000 and 31 December 2012, 338,908 Chinese adults with type 2 diabetes underwent metabolic and complication assessment in 16 diabetes centers operated by Hong Kong Hospital Authority that provided care to a large majority of diagnosed patients...
May 10, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28487451/infant-feeding-and-risk-of-type-1-diabetes-in-two-large-scandinavian-birth-cohorts
#18
Nicolai A Lund-Blix, Stine Dydensborg Sander, Ketil Størdal, Anne-Marie Nybo Andersen, Kjersti S Rønningen, Geir Joner, Torild Skrivarhaug, Pål R Njølstad, Steffen Husby, Lars C Stene
OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes. RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996-2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study and the Danish National Birth Cohort. Parents reported infant dietary practices when their child was 6 and 18 months old...
May 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28483786/faster-aspart-versus-insulin-aspart-as-part-of-a-basal-bolus-regimen-in-inadequately-controlled-type-2-diabetes-the-onset-2-trial
#19
Keith Bowering, Christopher Case, John Harvey, Michael Reeves, Michael Sampson, Robert Strzinek, Ditte-Marie Bretler, Rikke Beck Bang, Bruce W Bode
OBJECTIVE: This multicenter, double-blind, treat-to-target, phase 3 trial evaluated the efficacy and safety of fast-acting insulin aspart (faster aspart) versus insulin aspart (IAsp) in adults with type 2 diabetes receiving basal insulin and oral antidiabetic agents. RESEARCH DESIGN AND METHODS: The primary end point was HbA1c change from baseline after 26 weeks' treatment. After an 8-week run-in to optimize basal insulin, subjects were randomized (1:1) to mealtime faster aspart (n = 345) or IAsp (n = 344), titrated using a simple daily patient-driven algorithm, plus insulin glargine U100 and metformin...
May 8, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28476871/amylase-lipase-and-acute-pancreatitis-in-people-with-type-2-diabetes-treated-with-liraglutide-results-from-the-leader-randomized-trial
#20
William M Steinberg, John B Buse, Marie Louise Muus Ghorbani, David D Ørsted, Michael A Nauck
OBJECTIVE: To evaluate serum amylase and lipase levels and the rate of acute pancreatitis in patients with type 2 diabetes and high cardiovascular risk randomized to liraglutide or placebo and observed for 3.5-5.0 years. RESEARCH DESIGN AND METHODS: A total of 9,340 patients with type 2 diabetes were randomized to either liraglutide or placebo (median observation time 3.84 years). Fasting serum lipase and amylase were monitored. Acute pancreatitis was adjudicated in a blinded manner...
May 5, 2017: Diabetes Care
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