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Developmental Medicine and Child Neurology

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https://www.readbyqxmd.com/read/29058318/seizure-outcome-after-corpus-callosotomy-in-a-large-paediatric-series
#1
David Graham, Deepak Gill, Russell C Dale, Martin M Tisdall
AIM: To describe 20 years of experience with corpus callosotomy at Great Ormond Street Hospital for Children, London and the Children's Hospital at Westmead, Sydney. METHOD: Records of patients who underwent corpus callosotomy between January 1995 and December 2015 were reviewed. Complications of surgery and changes in seizure type and frequency, injuries, and use of antiepileptic drugs were recorded. Drop attacks were analysed using Kaplan-Meier event-free survival curves...
October 23, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29058313/the-role-of-social-risk-in-an-early-preventative-care-programme-for-infants-born-very-preterm-a-randomized-controlled-trial
#2
Alicia J Spittle, Karli Treyvaud, Katherine J Lee, Peter J Anderson, Lex W Doyle
AIM: To examine the differential effects of an early intervention programme for infants born preterm on neurodevelopment and parental mental health according to family social risk. METHOD: One hundred and twenty infants born earlier than 30 weeks' gestation were randomized to early intervention (n=61) or control groups (n=59). Cognitive, language, and motor outcomes were assessed by blinded assessors at 2 years, 4 years, and 8 years, and primary caregivers completed questionnaires on their anxiety and depression...
October 23, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29034455/diagnosis-in-the-age-of-massive-computing-power
#3
Steven M Day, Robert J Reynolds
No abstract text is available yet for this article.
October 16, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29027196/care-mapping-for-the-medically-complex-child
#4
Rhonda G Cady
No abstract text is available yet for this article.
October 13, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29023676/neurocognitive-problems-in-children-with-congenital-cytomegalovirus-infection
#5
Hermione Lyall
No abstract text is available yet for this article.
October 12, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29023666/nutritional-intervention-and-neurodevelopmental-outcome-in-infants-with-suspected-cerebral-palsy-the-dolphin-infant-double-blind-randomized-controlled-trial
#6
Morag J Andrew, Jeremy R Parr, Christine Montague-Johnson, Karen Laler, Cathy Qi, Bonny Baker, Peter B Sullivan
AIM: To investigate whether docosahexaenoic acid (DHA), choline, and uridine-5-monophosphate (UMP) supplementation improves neurodevelopmental outcome in infants with suspected cerebral palsy (CP) versus a comparison group of children. METHOD: Infants aged 1 to 18 months with suspected CP were recruited from UK child development centres. Participants received daily treatment or control supplementation for 2 years (double-blind randomized control design). Stratification was by age, sex, predominant pattern of motor involvement (four limbs or other), and visual impairment (or not)...
October 12, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29023650/the-hand-assessment-of-infants-a-new-tool-to-understand-early-hand-function-in-children-at-high-risk-of-unilateral-cerebral-palsy
#7
Alicia J Spittle
No abstract text is available yet for this article.
October 10, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28990181/long-term-impairment-attributable-to-congenital-cytomegalovirus-infection-a-retrospective-cohort-study
#8
Marjolein J Korndewal, Anne Marie Oudesluys-Murphy, Aloys C M Kroes, Marianne A B van der Sande, Hester E de Melker, Ann C T M Vossen
AIM: This study aimed to estimate long-term impairment attributable to congenital cytomegalovirus infection (cCMV). METHOD: This nationwide cohort study retrospectively assessed cCMV in children born in 2008 in the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of cCMV-positive children (n=133) and matched cCMV-negative comparison children (n=274) up to 6 years of age were analysed. RESULTS: Moderate to severe long-term impairment was diagnosed in 24...
October 9, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28990163/corticosteroids-in-duchenne-muscular-dystrophy-impact-on-the-motor-function-measure-sensitivity-to-change-and-implications-for-clinical-trials
#9
Audrey Schreiber, Sylvain Brochard, Pascal Rippert, Stephanie Fontaine-Carbonnel, Christine Payan, Isabelle Poirot, Dalil Hamroun, Carole Vuillerot
AIM: To monitor the evolution of the motor function of ambulatory patients with Duchenne muscular dystrophy (DMD) treated by corticosteroids for 2 years in comparison with untreated patients. METHOD: This observational, multicentre cohort study explores the evolution of the motor function measure (MFM) over a 24-month period for 29 ambulant corticosteroids-treated and 45 ambulant untreated patients with DMD. RESULTS: Significant differences were found between mean MFM scores in corticosteroids-treated and untreated groups for domain 1 of the MFM (standing position and transfers; D1), domain 2 of the MFM (axial and proximal motor function; D2), and domain 3 of the MFM (distal motor function; D3)...
October 9, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28984353/care-maps-for-children-with-medical-complexity
#10
Sherri Adams, David Nicholas, Sanjay Mahant, Natalie Weiser, Ronik Kanani, Katherine Boydell, Eyal Cohen
AIM: Children with medical complexity require multiple providers and services to keep them well and at home. A care map is a patient/family-created diagram that pictorially maps out this complex web of services. This study explored what care maps mean for families and healthcare providers to inform potential for clinical use. METHOD: Parents (n=15) created care maps (hand drawn n=10 and computer-generated n=5) and participated in semi-structured interviews about the process of developing care maps and their perceived impact...
October 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28984352/development-of-the-hand-assessment-for-infants-evidence-of-internal-scale-validity
#11
Lena Krumlinde-Sundholm, Linda Ek, Elisa Sicola, Lena Sjöstrand, Andrea Guzzetta, Giuseppina Sgandurra, Giovanni Cioni, Ann-Christin Eliasson
AIM: The aim of this study was to develop a descriptive and evaluative assessment of upper limb function for infants aged 3 to 12 months and to investigate its internal scale validity for use with infants at risk of unilateral cerebral palsy. METHOD: The concepts of the test items and scoring criteria were developed. Internal scale validity and aspects of reliability were investigated on the basis of 156 assessments of infants at 3 to 12 months corrected age (mean 7...
October 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28984349/quality-of-life-and-comorbidities-associated-with-dravet-syndrome-severity-a-multinational-cohort-survey
#12
Lieven Lagae, Isabella Brambilla, Ana Mingorance, Eddie Gibson, Alysia Battersby
AIM: To test the hypothesis that higher seizure burden in Dravet syndrome is associated with increased comorbidities and lower quality of life (QoL) in a large cohort of patients with Dravet syndrome and their caregivers in Europe. METHOD: An extensive survey of caregivers of patients with Dravet syndrome on experiences of diagnosis, seizure burden, management, social and financial impact, and health services use was administered online in 10 languages. RESULTS: The survey received 584 unique responses from caregivers of paediatric (83%) and adult (17%) patients with Dravet syndrome (aged <1-48y)...
October 6, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28980316/cerebral-palsy-after-assisted-reproductive-technology-a-cohort-study
#13
Shona Goldsmith, Sarah Mcintyre, Nadia Badawi, Michele Hansen
AIM: To calculate the birth prevalence of cerebral palsy (CP) after assisted reproductive technology (ART) and compare the clinical outcomes of children with CP after ART or natural conception. METHOD: This cohort study used linked CP and ART register data from live births in Western Australia (1994-2002). Birth prevalence was calculated and data analysed using descriptive statistics and logistic regression. It was adjusted for confounding variables and stratified by plurality and gestational age...
October 4, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28976014/risk-and-resilience-in-autism-spectrum-disorder-a-missed-translational-opportunity
#14
REVIEW
Peter Szatmari
The objective of this review is to provide a narrative summary of risk and resiliency in autism spectrum disorder (ASD) over the lifespan. In recent years, much has been learned about risk factors for ASD which include both genetic and environmental mechanisms. Resiliency in ASD is much less studied but examples can be gleaned by exploring studies that allow for heterogeneity in causation and outcome. Possible examples come from the literature on sex difference, infant siblings, and natural history. Exciting translational opportunities can be achieved through a greater focus on understanding protective factors and resiliency in ASD than the field's almost exclusive focus on risk factors and the ability to predict poor outcomes...
October 4, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28972277/high-sensitivity-and-specificity-in-proposed-clinical-diagnostic-criteria-for-anti-n-methyl-d-aspartate-receptor-encephalitis
#15
Alvin C C Ho, Shekeeb S Mohammad, Sekhar C Pillai, Esther Tantsis, Hannah Jones, Reena Ho, Ming Lim, Yael Hacohen, Angela Vincent, Russell C Dale
AIM: To determine the validity of the proposed clinical diagnostic criteria for anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in paediatric patients. METHOD: The diagnostic criteria for anti-NMDAR encephalitis proposed by Graus et al. (2016) use clinical features and conventional investigations to facilitate early immunotherapy before antibody status is available. The criteria are satisfied if patients develop four out of six symptom groups within 3 months, together with at least one abnormal investigation (electroencephalography/cerebrospinal fluid) and reasonable exclusion of other disorders...
October 3, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28972274/motor-system-plasticity-after-unilateral-injury-in-the-developing-brain
#16
REVIEW
Preston T J A Williams, Yu-Qiu Jiang, John H Martin
In maturity, motor skills depend on the corticospinal tract (CST) and brainstem pathways that together synapse on interneurons and motoneurons in the spinal cord. Descending signals to spinal neurons that mediate voluntary control can be distinguished from peripheral sensory signals, primarily for feedback control. These motor system circuits depend initially on developmental genetic mechanisms to establish their connections and neural activity- and use-dependent synaptic refinement during the early postnatal period to enable motor skills to develop...
October 3, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28967231/congenital-anomalies-and-the-severity-of-impairments-for-cerebral-palsy
#17
Kjersti P Jystad, Kristin M Strand, Solveig Bjellmo, Stian Lydersen, Kari Klungsöyr, Magne Stoknes, Jon Skranes, Guro L Andersen, Torstein Vik
AIM: To study the prevalence of congenital anomalies among children with cerebral palsy (CP) born at term or late preterm, and if CP subtypes and clinical manifestations differ between children with and without congenital anomalies. METHOD: This was a cross-sectional study using data from the Cerebral Palsy Register of Norway and the Medical Birth Registry of Norway. All children with congenital CP born at and later than 34 weeks' gestation in Norway from 1999 to 2009 were included...
October 2, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28963725/the-relationship-between-quality-of-life-and-health-related-quality-of-life-in-young-males-with-duchenne-muscular-dystrophy
#18
Yi Wei, Kathy Nixon Speechley, Guangyong Zou, Craig Campbell
AIM: This study investigated the relationship between quality of life (QoL) and health-related quality of life (HRQoL) and assessed factors other than health that contribute to differences in QoL in young males with Duchenne muscular dystrophy (DMD). METHOD: In this cross-sectional study, QoL and HRQoL measures were completed by 98 parents and 85 children. The Quality of My Life (QoML) questionnaire measured QoL and HRQoL as single-items, and the Pediatric Quality of Life 4...
September 30, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28944462/access-to-early-diagnostics-intervention-and-support-for-children-with-a-neurobiological-developmental-delay-or-disorder
#19
Eva Cloet, Mark Leys, Linda De Meirleir
No abstract text is available yet for this article.
September 25, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28940237/carpal-tunnel-syndrome-in-mucopolysaccharidosis-the-value-of-rare-disease-registries
#20
Klane K White
No abstract text is available yet for this article.
September 22, 2017: Developmental Medicine and Child Neurology
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