Read by QxMD icon Read

Dementia and Geriatric Cognitive Disorders

Carme Carrion, Frans Folkvord, Dimitra Anastasiadou, Marta Aymerich
BACKGROUND: Cognitive therapy is a well-established intervention for treating elderly suffering from dementia. In particular, reality orientation and skills training seem to be effective interventions for reversing cognitive impairment among elderly, although findings are inconclusive. Therefore, a systematic update of the existing evidence of cognitive therapy for people suffering from dementia is needed. AIM: To review existing scientific evidence regarding the efficacy of cognitive therapies for elderly suffering from dementia...
August 9, 2018: Dementia and Geriatric Cognitive Disorders
Valeria Morichi, Massimiliano Fedecostante, Alessandro Morandi, Simona Gabriella Di Santo, Andrea Mazzone, Enrico Mossello, Mario Bo, Angelo Bianchetti, Renzo Rozzini, Ermellina Zanetti, Massimo Musicco, Alberto Ferrari, Nicola Ferrara, Marco Trabucchi, Antonio Cherubini, Giuseppe Bellelli
BACKGROUND: Delirium is a common geriatric syndrome. Few studies have been conducted in nursing home (NH) residents. The aim of this project was to perform a point prevalence study of delirium in Italian NHs. METHODS: Data collected in 71 NHs are presented. Inclusion criteria were age ≥65 years and native Italian speaker. Exclusion criteria were coma, aphasia, and end-of-life status. Sociodemographic and medical data were recorded. Delirium was assessed using the Assessment Test for Delirium and Cognitive Impairment (4-AT)...
August 9, 2018: Dementia and Geriatric Cognitive Disorders
João Durães, Miguel Tábuas-Pereira, Rui Araújo, Diana Duro, Inês Baldeiras, Beatriz Santiago, Isabel Santana
BACKGROUND/AIMS: The head turning sign (HTS) is frequently noticed in clinical practice, but few studies have investigated its etiological and neuropsychological correlates. METHODS: The presence and frequency of the HTS was operationalized and prospectively evaluated in patients with Alzheimer's disease (AD), amnestic mild cognitive impairment (MCI), and behavioral-variant frontotemporal dementia (bvFTD). Cerebrospinal fluid (CSF) samples for AD biomarkers were collected...
August 9, 2018: Dementia and Geriatric Cognitive Disorders
Ying-Chih Cheng, Yu-Chen Huang, Hsing-Cheng Liu
BACKGROUND: The apolipoprotein E ɛ4 (APOE ɛ4) genotype is the major genetic risk factor for Alzheimer's disease (AD). However, its effect on an individual's response to treatment is less well understood. Many studies have reported that the presence or absence of APOE ɛ4 may have influence on the therapeutic response for acetylcholinesterase inhibitors (AChEIs), but the results were inconsistent. This study performed a systematic review and meta-analysis to evaluate the association between response of treatment with AChEIs and the APOE ɛ4 carrier status...
July 24, 2018: Dementia and Geriatric Cognitive Disorders
Elham Dolatabadi, Karen Van Ooteghem, Babak Taati, Andrea Iaboni
BACKGROUND: Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls. SUMMARY: This systematic review provides a critical analysis of the evidence linking quantitative measures of gait and balance to fall risk in older adults with dementia. Various instrumented measures of gait and postural stability including gait speed and non-instrumented performance measures including Timed Up and Go were shown to be capable of distinguishing fallers from non-fallers...
July 24, 2018: Dementia and Geriatric Cognitive Disorders
Martin Rakusa, Joze Jensterle, Janez Mlakar
BACKGROUND/AIM: The Clock Drawing Test (CDT) is a valid alternative screening tool to the Mini-Mental State Examination (MMSE) and, crucially, it may be completed faster. The aim of our study was to standardize and simplify the CDT scoring system for screening in three common conditions: mild cognitive impairment (MCI), Alzheimer's disease (AD) and mixed dementia (MD). METHODS: We included 188 subjects (43 healthy volunteers, 49 patients with MCI, 54 patients with AD, and 42 patients with MD), who performed the MMSE and CDT...
July 23, 2018: Dementia and Geriatric Cognitive Disorders
John C Williamson, Andrew J Larner
BACKGROUND/AIMS: The Mini-Addenbrooke's Cognitive Examination (MACE) is a relatively new short cognitive screening instrument for the detection of patients with dementia and mild cognitive impairment (MCI). Few studies of the MACE have been reported hitherto. The aim of this study was to undertake a pragmatic diagnostic test accuracy study of MACE in a large cohort of patients seen in a dedicated cognitive disorders clinic. METHODS: MACE was administered to consecutive patients referred to a neurology-led Cognitive Function Clinic over the course of 3 years to assess its performance for the diagnosis of dementia and MCI using various test metrics...
July 11, 2018: Dementia and Geriatric Cognitive Disorders
Leonie J M Vergouw, Mariet Salomé, Anke G Kerklaan, Christiaan Kies, Gerwin Roks, Esther van den Berg, Frank Jan de Jong
AIMS: To determine whether the pentagon copying test (PCT) and the clock drawing test (CDT) are associated with nursing home admission or survival in dementia with Lewy bodies (DLB). METHODS: The PCT and/or the CDT were retrospectively collected from 103 clinically diagnosed probable DLB patients at a university medical center and general hospital. Patients with high versus low scores on these tests were compared. RESULTS: Kaplan-Meier analysis showed that patients with a low score on the PCT had a shorter time to nursing home admission than patients with a high score (log-rank χ2 = 6...
July 11, 2018: Dementia and Geriatric Cognitive Disorders
Robert Fieo, Yaakov Stern
BACKGROUND/AIMS: Dementia exhibits an insidious onset consisting of cognitive, behavioral, and functional impairment. We explored a functional continuum that extends assessment beyond the clinical instrumental activities of daily living (IADL) range and into advanced activities of daily living. METHODS: We examined the predictive power (Cox regression; n = 2,471) of a unidimensional IADL-extended (IADL-x) scale for incident mild cognitive impairment (MCI). We also examined "time to MCI" as an outcome measure...
July 11, 2018: Dementia and Geriatric Cognitive Disorders
Seonjeong Byun, Ji Won Han, Tae Hui Kim, Kayoung Kim, Tae Hyun Kim, Jae Young Park, Seung Wan Suh, Ji Young Seo, Yoonseop So, Kyoung Hwan Lee, Ju Ri Lee, Hyeon Jeong, Hyun-Ghang Jeong, Kyuhee Han, Jong Woo Hong, Ki Woong Kim
BACKGROUND: The aim of this study was to investigate the association of gait speed and gait variability, an index of how much gait parameters, such as step time, fluctuate step-to-step, with risk of cognitive decline in cognitively normal elderly individuals. While high gait variability is emerging as an early indicator of dementing illnesses, there is little research on whether high gait variability predicts cognitive decline in cognitively normal elderly who have no evidence of cognitive impairment...
June 28, 2018: Dementia and Geriatric Cognitive Disorders
Yu-Hao Xue, Yu-Shin Peng, Hsin-Fu Ting, Jason Peijer Hsieh, Yu-Kai Huang, Yu-Hsun Wang, Jeng-Yuan Chiou, James Cheng-Chung Wei
INTRODUCTION: This population-based cohort study investigates the association between osteoarthritis (OA) and dementia as well as the connection between NSAIDs and dementia. METHODS: We chose the samples from the Taiwan Longitudinal Health Insurance Database and then divided them into two groups, which were then matched 1: 1 by propensity score. The first group was the OA group that contained patients with newly diagnosed OA and the second group was the non-OA group...
June 28, 2018: Dementia and Geriatric Cognitive Disorders
Aline Mendes, Sophie Tezenas du Montcel, Marcel Levy, Anne Bertrand, Marie-Odile Habert, Hugo Bertin, Bruno Dubois, Stéphane Epelbaum
BACKGROUND: Identifying comorbidities that influence preclinical Alzheimer's disease (AD) can give some insight into the AD early stages trajectories to allow new treatment venues and to guide public health systems to prevent subsequent dementia. OBJECTIVE: To examine the association of multimorbidity with AD neuroimaging markers in cognitively normal older adults. METHODS: This study had a cross-sectional design. Data regarding 14 comorbidities were obtained for all 318 adults aged 70-85 years, recruited from the community to an ongoing prospective monocentric cohort...
June 28, 2018: Dementia and Geriatric Cognitive Disorders
Hitoshi Okamura, Michiaki Otani, Naonori Shimoyama, Takayuki Fujii
BACKGROUND/AIMS: We investigated the efficacy of a combined exercise and cognitive training system that we devised for improvement of attention and concentration, cognition, and activities of daily living in older adults with dementia. METHODS: A total of 100 dementia patients were randomly assigned to an intervention group or a control group. The intervention group was subjected to a combined exercise and cognitive training for 6 consecutive weeks. Evaluations were performed using the Trail Making Test-Part A, the Mini-Mental State Examination, and an N-type activities of daily living evaluation scale for the elderly...
2018: Dementia and Geriatric Cognitive Disorders
Tiago C C Pinto, Leonardo Machado, Tatiana M Bulgacov, Antônio L Rodrigues-Júnior, Maria Lúcia G Costa, Rosana C C Ximenes, Everton B Sougey
AIMS: To provide normative data for the Brazilian version of the Montreal Cognitive Assessment (MoCA-BR) and to measure the effect of sociodemographic variables on the cognitive performance of cognitively healthy elderly people. METHODS: A sample of 110 cognitively healthy individuals, aged over 65 years, with at least 4 years of schooling were recruited from 3 health care centers for the elderly in Recife, Brazil. The cognitive performance was assessed using MoCA-BR...
2018: Dementia and Geriatric Cognitive Disorders
Romee van Dam, Jeanine M Van Ancum, Sjors Verlaan, Kira Scheerman, Carel G M Meskers, Andrea B Maier
BACKGROUND: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT)...
2018: Dementia and Geriatric Cognitive Disorders
Alexandra König, Nicklas Linz, Johannes Tröger, Maria Wolters, Jan Alexandersson, Phillipe Robert
BACKGROUND: Semantic verbal fluency (SVF) tests are routinely used in screening for mild cognitive impairment (MCI). In this task, participants name as many items as possible of a semantic category under a time constraint. Clinicians measure task performance manually by summing the number of correct words and errors. More fine-grained variables add valuable information to clinical assessment, but are time-consuming. Therefore, the aim of this study is to investigate whether automatic analysis of the SVF could provide these as accurate as manual and thus, support qualitative screening of neurocognitive impairment...
2018: Dementia and Geriatric Cognitive Disorders
Adam P Mecca, Hannah R Michalak, Julia W McDonald, Emily C Kemp, Erika A Pugh, Melinda L Becker, Marcia C Mecca, Christopher H van Dyck
BACKGROUND: We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS: Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer's Disease Neuroimaging Initiative), a longitudinal cohort study. RESULTS: Sleep disturbance was not associated with decline in memory, executive function, or global cognition...
2018: Dementia and Geriatric Cognitive Disorders
Yifan Zheng, Qi Wu, Fengjuan Su, Yingying Fang, Jinsheng Zeng, Zhong Pei
BACKGROUND: Several studies have found that bilingualism can delay the age of onset of Alz-heimer disease (AD). The interpretation of these findings is that switching between two languages can enhance cognitive reserve. However, some studies have provided inconsistent results. Diverse language pairs used by the bilinguals in different studies may contribute to the discrepancies. Cantonese and Mandarin are widely used in southern China, and regarded as bilingualism. The present study aims to determine if Cantonese/Mandarin bilingualism can delay the onset of AD...
2018: Dementia and Geriatric Cognitive Disorders
Elena Cortés-Vicente, Janina Turon-Sans, Ellen Gelpi, Jordi Clarimón, Sergi Borrego-Écija, Oriol Dols-Icardo, Ignacio Illán-Gala, Alberto Lleó, Isabel Illa, Rafael Blesa, Ammar Al-Chalabi, Ricard Rojas-García
AIM: To determine the motor phenotype and outcome in a clinically ascertained group of patients with motor neuron disease (MND) and frontotemporal dementia (FTD). METHODS: This is an observational retrospective clinical study of patients fulfilling the clinical criteria for MND-FTD. A contemporary series of patients with amyotrophic lateral sclerosis (ALS) without dementia were included for comparison. Demographic, clinical, genetic, and neuropathological data were collected...
2018: Dementia and Geriatric Cognitive Disorders
Andreas Ihle, Michel Oris, Julia Sauter, Ulrike Rimmele, Matthias Kliegel
AIMS: The present study set out to investigate the relation of psychological stress to cognitive performance and its interplay with key life course markers of cognitive reserve and social capital in a large sample of older adults. METHODS: We assessed cognitive performance (verbal abilities and processing speed) and psychological stress in 2,812 older adults. The Participants reported information on education, occupation, leisure activities, family, and close friends...
2018: Dementia and Geriatric Cognitive Disorders
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"