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Dementia and Geriatric Cognitive Disorders

Ales Bartos, Dan Fayette
BACKGROUND: The Czech version of the Montreal Cognitive Assessment (MoCA-CZ) and delayed recall of 5 words have not been validated in patients with mild cognitive impairment (MCI) due to Alzheimer disease (AD) and compared to norms of a large population. METHOD: The MoCA-CZ was administered to 1,600 elderly individuals in 2 groups consisting of 48 patients with MCI due to AD (AD-MCI) and 1,552 normal elderly adults. RESULTS: MoCA-CZ scores were significantly lower in the AD-MCI patients than in the normal elderly (21 ± 4 vs...
December 4, 2018: Dementia and Geriatric Cognitive Disorders
Mélanie Barbay, Momar Diouf, Martine Roussel, Olivier Godefroy
BACKGROUND/AIMS: Post-stroke neurocognitive disorders (post-stroke NCD) have been reported with a very variable prevalence. METHODS: Based on a systematic literature search, hospital-based studies published between January 1990 and September 2015 were selected when they reported the prevalence of total, mild, and major post-stroke NCD diagnosed by using specified criteria. Factors affecting prevalence were assessed using meta-regression analysis. RESULTS: Among the 7,440 references evaluated, 16 hospital-based studies were selected, corresponding to a total of 3,087 patients...
November 30, 2018: Dementia and Geriatric Cognitive Disorders
Leila Sellami, Synthia Meilleur-Durand, Anne-Marie Chouinard, David Bergeron, Louis Verret, Stéphane Poulin, Léonie Jean, Marie-Pierre Fortin, Yannick Nadeau, Pierre Molin, Stéphanie Caron, Joël Macoir, Carol Hudon, Rémi W Bouchard, Robert Laforce
INTRODUCTION: Early recognition of atypical dementia remains challenging partly because of lack of cognitive screening instruments precisely tailored for this purpose. METHODS: We assessed the validity and reliability of the Dépistage Cognitif de Québec (DCQ;, a newly developed cognitive screening test, to detect atypical dementia using a multicenter cohort of 628 participants. Sensitivity and specificity were compared to the Montreal Cognitive Assessment (MoCA)...
November 27, 2018: Dementia and Geriatric Cognitive Disorders
Sophie Vandepitte, Koen Putman, Nele Van Den Noortgate, Sofie Verhaeghe, Eric Mormont, Lisa Van Wilder, Delphine De Smedt, Lieven Annemans
BACKGROUND/AIMS: Dementia is one of the main reasons for institutionalization among the elderly. Few studies have explored factors associated with the caregivers' (CG) desire to institutionalize (DTI) a person with dementia (PWD). The objective of this study is to identify modifiable and non-modifiable psychosocial and sociodemographic factors associated with a caregiver's DTI. METHODS: Cross-sectional data of 355 informal CG of community-dwelling PWD were analyzed...
November 19, 2018: Dementia and Geriatric Cognitive Disorders
Courtney Lewis, Mark Walterfang, Dennis Velakoulis, Adam P Vogel
BACKGROUND: Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common and significant outcome of FTLD. Disturbances during mealtimes can arise from dysphagia or may occur secondary to behavioral changes such as rapid eating, mealtime rigidity, and altered diet preferences. SUMMARY: Few studies have comprehensively evaluated eating behavior or dysphagia in individuals presenting with FTLD pathology despite the potential impact on medical safety and individual quality of life...
November 13, 2018: Dementia and Geriatric Cognitive Disorders
Mark S Redfern, April J Chambers, Patrick J Sparto, Joseph M Furman, J Richard Jennings
AIMS: Inhibition associated with perception has been implicated in sensory integration processes for balance when sensory conflict occurs. The current study examines the associations of three measures of inhibition (perceptual inhibition, motor inhibition, and Stroop interference) with standing balance under sensory conflict conditions in younger and older adults. METHODS: Perceptual inhibition, motor inhibition, and Stroop interference were measured in younger and older subjects...
November 7, 2018: Dementia and Geriatric Cognitive Disorders
Irina V Tarasova, Olga A Trubnikova, Olga L Barbarash
BACKGROUND: Although an impaired cognitive status in patients with coronary artery disease (CAD) is not rare, the neurophysiological and clinical indicators of mild cognitive impairment (MCI) have been insufficiently investigated so far. METHODS: EEG and neuropsychological testing as well as clinical examination were performed on 122 patients with CAD, who were divided into two groups, those with MCI (n = 60; mean age 57.4 ± 5.81 years) and those without MCI (n = 62; mean age 57...
November 7, 2018: Dementia and Geriatric Cognitive Disorders
Christina G Wong, Kelsey R Thomas, Emily C Edmonds, Alexandra J Weigand, Katherine J Bangen, Joel S Eppig, Amy J Jak, Sherral A Devine, Lisa Delano-Wood, David J Libon, Steven D Edland, Rhoda Au, Mark W Bondi
BACKGROUND/AIMS: Mild cognitive impairment (MCI) lacks a "gold standard" operational definition. The Jak/Bondi actuarial neuropsychological criteria for MCI are associated with improved diagnostic stability and prediction of progression to dementia compared to conventional MCI diagnostic approaches, although its utility in diagnosing MCI in old-old individuals (age 75+) is unknown. Therefore, we investigated the applicability of neuropsychological MCI criteria among old-old from the Framingham Heart Study...
November 2, 2018: Dementia and Geriatric Cognitive Disorders
Petronilla Battista, Eleonora Catricalà, Marco Piccininni, Massimiliano Copetti, Valentina Esposito, Cristina Polito, Antonio Miozzo, Elena Gobbi, Sofia Cuoco, Veronica Boschi, Marina Picillo, Sandro Sorbi, Paolo Barone, Sandro Iannaccone, Peter Garrard, Giancarlo Logroscino, Stefano F Cappa
BACKGROUND: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients. METHODS: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC). RESULTS: The SAND battery showed good internal consistency and good convergent and divergent validity...
2018: Dementia and Geriatric Cognitive Disorders
Dong Woo Kang, Hyun Kook Lim, Soo-Hyun Joo, Na Rae Lee, Chang-Uk Lee
BACKGROUND: Previous research has separated spatial patterns of intra- and interregional intrinsic brain connectivity, as evaluated by regional homogeneity (ReHo) and functional connectivity (FC), respectively, in prodromal Alzheimer's disease (AD). Moreover, the intra- and interregional intrinsic brain connectivities have been demonstrated to have a significant relationship with each other. OBJECTIVE: To explore FCs from brain regions which display a difference in ReHo between an amnestic mild cognitive impairment (aMCI) group and healthy controls (HC) and to examine the relationship of intra- and interregional intrinsic brain connectivity to cognitive function in both groups...
2018: Dementia and Geriatric Cognitive Disorders
Chi-Mo Lin, Guang-Uei Hung, Cheng-Yu Wei, Ray-Chang Tzeng, Pai-Yi Chiu
BACKGROUND/AIMS: Language dysfunction is a crucial feature of brain disorders. This study investigated language dysfunction in patients with dementia with or without parkinsonism by using an informant-based simple questionnaire. METHODS: Language dysfunction in normal controls (NCs), and patients with Parkinson disease (PD), Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), or Alzheimer disease (AD) were analyzed and compared. RESULTS: A total of 1,662 individuals were studied: 285 NCs, 157 PD patients, 161 PDD patients, 248 DLB patients, and 811 AD patients...
2018: Dementia and Geriatric Cognitive Disorders
Mona Michelet, Knut Engedal, Geir Selbæk, Anne Lund, Guro Hanevold Bjørkløf, Peter Otto Horndalsveen, Sverre Bergh
BACKGROUND/AIMS: A timely diagnosis of dementia is important, and the Cognitive Function Instrument (CFI) is a newly developed instrument to screen for cognitive decline. The aim of this study was to evaluate the validity and internal consistency of the Norwegian version of the CFI. METHODS: We included 265 participants with dementia, mild cognitive impairment (MCI), subjective cognitive impairment (SCI), and a reference group without subjective or assessed cognitive decline...
2018: Dementia and Geriatric Cognitive Disorders
Gunnar Lachmann, Insa Feinkohl, Friedrich Borchers, Thomas H Ottens, Hendrik M Nathoe, Anne-Mette Sauer, Jan M Dieleman, Finn M Radtke, Diederik van Dijk, Claudia Spies, Tobias Pischon
BACKGROUND/AIMS: Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS: Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on diabetes, hypertension, baseline blood pressure, obesity (BMI ≥30 kg/m2), and BMI as risk factors for POCD in multiple logistic regression models...
2018: Dementia and Geriatric Cognitive Disorders
Brittany L Mason, Elena I Ivleva, Erin Van Enkevort, Alyson Nakamura, E Sherwood Brown
BACKGROUND: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed. METHODS: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. RESULTS: Megestrol was associated with a significant reduction in declarative memory (p = 0...
2018: Dementia and Geriatric Cognitive Disorders
Anthony Fourier, Maité Formaglio, Mathilde Sauvée, Armand Perret-Liaudet, Philippe Latour, Muriel Bost, Isabelle Quadrio
BACKGROUND/AIMS: The aim of the study was to assess the theory of haploinsufficiency in C9ORF72 expansion carriers, the most frequent causative gene of frontotemporal dementia. METHODS: Plasmatic concentrations of C9orf72 protein were measured in 33 patients suspected of familial frontotemporal dementia using an enzyme-linked immunosorbent assay. RESULTS: No difference was observed between C9ORF72 expansion carriers (21.2% of patients) and noncarriers (78...
2018: Dementia and Geriatric Cognitive Disorders
Frederikke Jeppesen Kragh, Marie Bruun, Esben Budtz-Jørgensen, Lena Elisabeth Hjermind, Robin Schubert, Ralf Reilmann, Jørgen Erik Nielsen, Steen Gregers Hasselbalch
BACKGROUND: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). METHODS: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping...
2018: Dementia and Geriatric Cognitive Disorders
Michele Lauriola, Antonio Mangiacotti, Grazia D'Onofrio, Leandro Cascavilla, Francesco Paris, Filomena Ciccone, Monica Greco, Giulia Paroni, Davide Seripa, Antonio Greco
BACKGROUND/AIM: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. METHODS: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. RESULTS: The risk to develop AD, within 4 years, was 68...
2018: Dementia and Geriatric Cognitive Disorders
Yejin Kim, Paul Rosenberg, Esther Oh
BACKGROUND: Molecular imaging of brain amyloid for the diagnosis of Alzheimer's disease (AD) using positron emission tomography (PET) has been approved for use in clinical practice by the Food and Drug Administration (FDA) since 2012. However, the clinical utility and diagnostic impact of amyloid PET imaging remain controversial. We conducted a review of the recent studies investigating clinical utility of amyloid PET imaging with focus on changes in diagnosis, diagnostic confidence, and patient management...
2018: Dementia and Geriatric Cognitive Disorders
Hajime Takechi, Yuriko Sugihara, Hitomi Matsumoto, Hiroko Yamada
BACKGROUND/AIMS: Dementia cafés are becoming widespread as a new approach to dementia care, but their operational procedures and significance have not been adequately studied. METHODS: On-the-job training (OJT) for professionals planning to operate a dementia café in the future was conducted in a pioneering dementia café in Japan. The reports of OJT trainees' observations and learning were analyzed qualitatively. RESULTS: Reports could be summarized in up to 9 themes: 2 related to the atmosphere and significance of the café, 3 related to the guests, such as people with dementia and their families, and 4 related to the café staff...
2018: Dementia and Geriatric Cognitive Disorders
Charlotte R Stoner, Martin Orrell, Aimee Spector
BACKGROUND/AIMS: Independence and social engagement are important outcomes for people with dementia. The aim of this study was to conduct an in-depth psychometric assessment of the Engagement and Independence in Dementia Questionnaire (EID-Q), a measure of social independence. METHODS: This was an observational study at five NHS sites across England. Participants completed the EID-Q alongside additional measures. Psychometric analysis included internal consistency, test-retest reliability, convergent validity, and factor analyses...
2018: Dementia and Geriatric Cognitive Disorders
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