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Dementia and Geriatric Cognitive Disorders

Felicia C Goldstein, Aaron Milloy, David W Loring
BACKGROUND/AIMS: The aim of this paper was to evaluate the incremental validity of the Montreal Cognitive Assessment (MoCA) index scores and the MoCA total score in differentiating individuals with normal cognition versus mild cognitive impairment (MCI) or Alzheimer disease (AD). METHODS: Effect sizes were calculated for Alzheimer's Disease Neuroimaging Initiative research participants with normal cognition (n = 295), MCI (n = 471), or AD (n = 150). RESULTS: Effect sizes for the total score were large (> 0...
April 11, 2018: Dementia and Geriatric Cognitive Disorders
Chavit Tunvirachaisakul, Thitiporn Supasitthumrong, Sookjareon Tangwongchai, Solaphat Hemrunroj, Phenphichcha Chuchuen, Itthipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchinda, Sira Sriswasdi, Michael Maes
BACKGROUND: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) developed a neuropsychological battery (CERAD-NP) to screen patients with Alzheimer's dementia. Mild cognitive impairment (MCI) has received attention as a pre-dementia stage. OBJECTIVES: To delineate the CERAD-NP features of MCI and their clinical utility to externally validate MCI diagnosis. METHODS: The study included 60 patients with MCI, diagnosed using the Clinical Dementia Rating, and 63 normal controls...
April 4, 2018: Dementia and Geriatric Cognitive Disorders
Stanislav Sutovsky, Maria Kralova, Pavol Siarnik, Peter Turcani
BACKGROUND/AIMS: Dementia and psychiatric disorders are common in assisted living facilities (ALFs) and have suboptimal rates of recognition and treatment. Therefore, we aimed to obtain a direct estimate of the prevalence of cognitive impairment and especially dementia among residents of ALFs in western Slovakia and their rates of primary recognition and adequate treatment. METHODS: We conducted two cross-sectional studies. Ten ALFs within the city of Bratislava were chosen for the study in 2004, and again in 2011...
March 22, 2018: Dementia and Geriatric Cognitive Disorders
Antoine Brangier, Sébastien Celle, Frédéric Roche, Olivier Beauchet, Guylaine Ferland, Cédric Annweiler
BACKGROUND: Vitamin K antagonists (VKAs) are commonly used for their role in haemostasis by interfering with the vitamin K cycle. Since vitamin K also participates in brain physiology, this voxel-based morphometric study aimed to determine whether the duration of exposure to VKAs correlated with focal brain volume reduction in older adults. METHODS: In this exposed/unexposed (1: 2) study nested within the GAIT (Gait and Alzheimer Interactions Tracking) cohort, 18 participants exposed to VKA (mean age 75 ± 5 years; 33...
February 27, 2018: Dementia and Geriatric Cognitive Disorders
Elizabeth E Blue, Joshua C Bis, Michael O Dorschner, Debby W Tsuang, Sandra M Barral, Gary Beecham, Jennifer E Below, William S Bush, Mariusz Butkiewicz, Carlos Cruchaga, Anita DeStefano, Lindsay A Farrer, Alison Goate, Jonathan Haines, Jim Jaworski, Gyungah Jun, Brian Kunkle, Amanda Kuzma, Jenny J Lee, Kathryn L Lunetta, Yiyi Ma, Eden Martin, Adam Naj, Alejandro Q Nato, Patrick Navas, Hiep Nguyen, Christiane Reitz, Dolly Reyes, William Salerno, Gerard D Schellenberg, Sudha Seshadri, Harkirat Sohi, Timothy A Thornton, Otto Valadares, Cornelia van Duijn, Badri N Vardarajan, Li-San Wang, Eric Boerwinkle, Josée Dupuis, Margaret A Pericak-Vance, Richard Mayeux, Ellen M Wijsman
BACKGROUND/AIMS: The Alzheimer's Disease Sequencing Project (ADSP) aims to identify novel genes influencing Alzheimer's disease (AD). Variants within genes known to cause dementias other than AD have previously been associated with AD risk. We describe evidence of co-segregation and associations between variants in dementia genes and clinically diagnosed AD within the ADSP. METHODS: We summarize the properties of known pathogenic variants within dementia genes, describe the co-segregation of variants annotated as "pathogenic" in ClinVar and new candidates observed in ADSP families, and test for associations between rare variants in dementia genes in the ADSP case-control study...
February 27, 2018: Dementia and Geriatric Cognitive Disorders
Ko Matsuo, Akihiro Shindo, Atsushi Niwa, Ken-Ichi Tabei, Hiroyasu Akatsu, Yoshio Hashizume, Haruhiko Akiyama, Takashi Ayaki, Takakuni Maki, Nobukatsu Sawamoto, Ryosuke Takahashi, Shinji Oikawa, Hidekazu Tomimoto
BACKGROUND: Cerebral amyloid angiopathy (CAA) is classified as type 1 with capillary amyloid β (Aβ) or type 2 without capillary Aβ. While it is known that CAA activates complement, an inflammatory mediator, there is no information on the relationship between capillary Aβ and complement activation. METHODS: We evaluated 34 autopsy brains, including 22 with CAA and 12 with other neurodegenerative diseases. We assessed the vascular density of CAA by analyzing the expression of complement (C1q, C3d, C6, C5b-9), macrophage scavenger receptor (MSR), and apolipoprotein E (ApoE)...
February 8, 2018: Dementia and Geriatric Cognitive Disorders
María Eugenia López, Agustín Turrero, María Luisa Delgado, Inmaculada Concepción Rodríguez-Rojo, Juan Arrazola, Ana Barabash, Fernando Maestú, Alberto Fernández
AIM: To test the association between cognitive performance and APOE genotype, and to assess potential modifications of this association by sociodemographic and neuroanatomical factors in a sample of 74 healthy elders. METHODS: Firstly, we explored the isolated role of the APOE ɛ4 genotype (i.e., APOE4) in different neuropsychological tests, and then the effects of its interaction with sociodemographic (i.e., age, gender, and educational level) and neuroanatomical (i...
February 7, 2018: Dementia and Geriatric Cognitive Disorders
Yunier Broche-Pérez, Héctor Alejandro López-Pujol
BACKGROUND/AIMS: The diagnostic accuracy of the Cuban version of the revised Addenbrooke's Cognitive Examination (ACE-R) in identifying mild cognitive impairment (MCI) in comparison with the Mini-Mental State Examination (MMSE) was assessed. METHODS: The Cuban ACE-R was administered to a group of 129 elderly subjects (92 cognitively healthy and 37 subjects with MCI). The t tests for independent samples were used to compare scores of different psychometric scales between groups, and effect sizes (Cohen's d) were calculated...
January 30, 2018: Dementia and Geriatric Cognitive Disorders
Ariana Gatt, Antigoni Ekonomou, Alyma Somani, Sandrine Thuret, David Howlett, Anne Corbett, Mary Johnson, Elaine Perry, Johannes Attems, Paul Francis, Dag Aarsland, Clive Ballard
OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD). METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs)...
January 27, 2018: Dementia and Geriatric Cognitive Disorders
Mustafa Atee, Kreshnik Hoti, Jeffery D Hughes
BACKGROUND/AIMS: Pain is common in aged care residents with dementia; yet it often goes undetected. A novel tool, the electronic Pain Assessment Tool (ePAT), was developed to address this challenging problem. We investigated the psychometric properties of the ePAT. METHODS: In a 10-week prospective observational study, the ePAT was evaluated by comparison against the Abbey Pain Scale (APS). Pain assessments were blindly co-performed by the ePAT rater against the nursing staff of two residential aged care facilities...
January 23, 2018: Dementia and Geriatric Cognitive Disorders
Kuan-Hua Chen, Jenna L Wells, Marcela C Otero, Sandy J Lwi, Claudia M Haase, Robert W Levenson
BACKGROUND: Behavioral symptoms in patients with neurodegenerative diseases can be particularly challenging for caregivers. Previously, we reported that patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD) experienced emotions that were atypical or incongruent with a given situation (i.e., non-target emotions). AIM: We tested the hypothesis that greater experience of non-target emotions by patients is associated with lower caregiver emotional well-being...
December 8, 2017: Dementia and Geriatric Cognitive Disorders
Jee-Yon Lee, Jung-Ha Kim, Duk-Chul Lee
BACKGROUND: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. METHODS: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. RESULTS: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0...
October 6, 2017: Dementia and Geriatric Cognitive Disorders
Byoung Seok Ye, Seun Jeon, Jee Hyun Ham, Jae Jung Lee, Jong Min Lee, Hye Sun Lee, Phil Hyu Lee, Young H Sohn
BACKGROUND: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. METHODS: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk...
September 21, 2017: Dementia and Geriatric Cognitive Disorders
Roger Watson, Annamaria Bagnasco, Gianluca Catania, Giuseppe Aleo, Milko Zanini, Loredana Sasso
AIMS/BACKGROUND: The Edinburgh Feeding Evaluation in Dementia (EdFED) scale has been shown to have good psychometric properties using a range of methods including Mokken scaling. We aimed to study the Italian version of the EdFED using Mokken scaling. METHODS: Data were gathered at 7 time points from 401 nursing home residents affected by dementia in the course of a 6-month intervention study using analysis of variance, Mokken scaling, and person-item fit statistics...
September 8, 2017: Dementia and Geriatric Cognitive Disorders
Yun Kyung Hwang, Eosu Kim, Yong Bum Kim, Yong Wook Kim, Chung Mo Nam, Seung-Hun Cho, HyangHee Kim
BACKGROUND: Naming difficulties have recently garnered more interest in elderly individuals with mild cognitive impairment (MCI). We anticipate that naming tests with the consideration of response time can provide more informative and distinct neuropsychological profiles of individuals with MCI. METHODS: Naming tests were administered to 76 elderly individuals with MCI and 149 healthy elderly (HE). We analyzed the impact of MCI on naming performance and occurrence of "delayed" response...
September 5, 2017: Dementia and Geriatric Cognitive Disorders
Emma Grace Lewis, Jessica Banks, Stella-Maria Paddick, Ashanti Duinmaijer, Laura Tucker, Aloyce Kisoli, Jane Cletus, Carolyn Lissu, Kajiru Kilonzo, Glynis Cosker, Elizabeta Blagoja Mukaetova-Ladinska, Catherine Dotchin, William Gray, Richard Walker, Sarah Urasa
BACKGROUND: The risk factors for prevalent delirium in older hospitalised adults in Sub-Saharan Africa (SSA) remain poorly characterised. METHODS: A total of 510 consecutive admissions of adults aged ≥60 years to acute medical wards of Kilimanjaro Christian Medical Centre in northern Tanzania were recruited. Patients were assessed within 24 h of admission with a risk factor questionnaire, physiological observations, neurocognitive assessment, and informant interview...
September 5, 2017: Dementia and Geriatric Cognitive Disorders
Minjung Woo, Yujin Kim
AIMS: This study examined differences in corticocortical communication between adolescent ε4 carriers (ε4+) and noncarriers (ε4-) during a fluid intelligence task (Comprehensive Test of Nonverbal Intelligence [CTONI]). METHODS: Sixteen ε4+ and 20 ε4- individuals aged 13-15 years performed the CTONI while real-time EEG signals were acquired. Inter- and intrahemispheric coherences were analyzed. RESULTS: The ε4+ subjects exhibited lower inter- and intrahemispheric coherences than the ε4- individuals...
August 24, 2017: Dementia and Geriatric Cognitive Disorders
Mara Bourbouli, Michael Rentzos, Anastasia Bougea, Vasiliki Zouvelou, Vasilios C Constantinides, Ioannis Zaganas, Ioannis Evdokimidis, Elisabeth Kapaki, George P Paraskevas
BACKGROUND: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are nowadays recognized as spectrum disorders with a molecular link, the TAR DNA-binding protein 43 (TDP-43), rendering it a surrogate biomarker for these disorders. METHODS: We measured cerebrospinal fluid (CSF) levels of TDP-43, beta-amyloid peptide with 42 amino acids (Aβ42), total tau protein (τT), and tau protein phosphorylated at threonine 181 (τP-181) in 32 patients with ALS, 51 patients with FTD, and 17 healthy controls...
August 23, 2017: Dementia and Geriatric Cognitive Disorders
Michael J Pontecorvo, Andrew Siderowf, Bruno Dubois, P Murali Doraiswamy, Giovanni B Frisoni, Michael Grundman, Flavio Nobili, Carl H Sadowsky, Stephen Salloway, Anupa K Arora, Antoine Chevrette, Walter Deberdt, Grazia Dell'Agnello, Matthew Flitter, Nick Galante, Mark J Lowrey, Ming Lu, Anne McGeehan, Michael D Devous, Mark A Mintun
AIMS: To evaluate the impact of amyloid PET imaging on diagnosis and patient management in a multicenter, randomized, controlled study. METHODS: Physicians identified patients seeking a diagnosis for mild cognitive impairment or dementia, possibly due to Alzheimer disease (AD), and recorded a working diagnosis and a management plan. The patients underwent florbetapir PET scanning and were randomized to either immediate or delayed (1-year) feedback regarding amyloid status...
August 5, 2017: Dementia and Geriatric Cognitive Disorders
Hacer Dogan Varan, Gurkan Guner, Muhammet Cemal Kizilarslanoglu, Fatih Sumer, Rana Tuna Dogrul, Aykut Sagir, Cemile Ozsurekci, Hatice Caliskan, Cafer Balci, Gozde Sengul Aycicek, Filiz Akbiyik, Meltem Halil, Mustafa Cankurtaran, Burcu Balam Yavuz
BACKGROUND: The novel molecule endocan, which is released by endothelium and is regulated by proangiogenic and proinflammatory cytokines, may have a role in the pathophysiology of Alzheimer disease (AD). The aim of this study was to evaluate the relationship between serum endocan levels and AD. METHODS: A total of 134 patients (47 AD, 42 amnestic mild cognitive impairment [aMCI], and 45 control patients) 65 years of age and older were recruited in this study. Cognitive status of the patients was evaluated by performing the Montreal Cognitive Assessment (MOCA) and the Mini-Mental State Examination (MMSE)...
2017: Dementia and Geriatric Cognitive Disorders
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