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Dementia and Geriatric Cognitive Disorders

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https://www.readbyqxmd.com/read/29216633/greater-experience-of-negative-non-target-emotions-by-patients-with-neurodegenerative-diseases-is-related-to-lower-emotional-well-being-in-caregivers
#1
Kuan-Hua Chen, Jenna L Wells, Marcela C Otero, Sandy J Lwi, Claudia M Haase, Robert W Levenson
BACKGROUND: Behavioral symptoms in patients with neurodegenerative diseases can be particularly challenging for caregivers. Previously, we reported that patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD) experienced emotions that were atypical or incongruent with a given situation (i.e., non-target emotions). AIM: We tested the hypothesis that greater experience of non-target emotions by patients is associated with lower caregiver emotional well-being...
December 8, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28982094/combined-impact-of-telomere-length-and-mitochondrial-dna-copy-number-on-cognitive-function-in-community-dwelling-very-old-adults
#2
Jee-Yon Lee, Jung-Ha Kim, Duk-Chul Lee
BACKGROUND: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. METHODS: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. RESULTS: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0...
October 6, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28934750/frontotemporal-dementia-caused-by-the-p301l-mutation-in-the-mapt-gene-clinicopathological-features-of-13-cases-from-the-same-geographical-origin-in-barcelona-spain
#3
Sergi Borrego-Écija, Joana Morgado, Leire Palencia-Madrid, Oriol Grau-Rivera, Ramón Reñé, Isabel Hernández, Consuelo Almenar, Mircea Balasa, Anna Antonell, José Luis Molinuevo, Albert Lladó, Marian Martínez de Pancorbo, Ellen Gelpi, Raquel Sánchez-Valle
BACKGROUND/AIMS: We identified and studied 13 patients carrying the P301L mutation in the MAPT gene from the same area (Baix Llobregat County) in Barcelona, Spain. METHODS: The demographic and clinical features were reviewed retrospectively. Detailed neuropathological characterization was obtained in 9 subjects. To investigate the origin of the P301L mutation in these families, 20 single nucleotide polymorphisms (SNPs) in the MAPT gene were analyzed. RESULTS: The mean age at disease onset was 51 years and the mean disease duration was 7 years...
September 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28930751/dementia-predicting-cognitive-risk-score-and-its-correlation-with-cortical-thickness-in-parkinson-disease
#4
Byoung Seok Ye, Seun Jeon, Jee Hyun Ham, Jae Jung Lee, Jong Min Lee, Hye Sun Lee, Phil Hyu Lee, Young H Sohn
BACKGROUND: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. METHODS: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk...
September 21, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28881343/the-edinburgh-feeding-evaluation-in-dementia-scale-a-longitudinal-study-in-nursing-home-residents
#5
Roger Watson, Annamaria Bagnasco, Gianluca Catania, Giuseppe Aleo, Milko Zanini, Loredana Sasso
AIMS/BACKGROUND: The Edinburgh Feeding Evaluation in Dementia (EdFED) scale has been shown to have good psychometric properties using a range of methods including Mokken scaling. We aimed to study the Italian version of the EdFED using Mokken scaling. METHODS: Data were gathered at 7 time points from 401 nursing home residents affected by dementia in the course of a 6-month intervention study using analysis of variance, Mokken scaling, and person-item fit statistics...
September 8, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28869959/screening-of-cognitive-impairment-in-the-dialysis-population-a-scoping-review
#6
Aye San, Balaji Hiremagalur, Wendy Muircroft, Laurie Grealish
BACKGROUND: Cognitive impairment in end-stage kidney disease patients on dialysis is increasingly common. This study aimed to review the practice of screening and to evaluate the evidence on cognitive impairment prevalence in this population. METHODS: This scoping review of studies summarises the evidence on cognitive impairment in dialysis populations. The search included the Medline, CINAHL, Embase, PsycINFO, PubMed, and Cochrane Library databases for English-language articles published between 2000 and 2015...
September 5, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28869957/diagnostic-value-of-time-constrained-naming-test-in-mild-cognitive-impairment
#7
Yun Kyung Hwang, Eosu Kim, Yong Bum Kim, Yong Wook Kim, Chung Mo Nam, Seung-Hun Cho, HyangHee Kim
BACKGROUND: Naming difficulties have recently garnered more interest in elderly individuals with mild cognitive impairment (MCI). We anticipate that naming tests with the consideration of response time can provide more informative and distinct neuropsychological profiles of individuals with MCI. METHODS: Naming tests were administered to 76 elderly individuals with MCI and 149 healthy elderly (HE). We analyzed the impact of MCI on naming performance and occurrence of "delayed" response...
September 5, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28869952/risk-factors-for-delirium-in-older-medical-inpatients-in-tanzania
#8
Emma Grace Lewis, Jessica Banks, Stella-Maria Paddick, Ashanti Duinmaijer, Laura Tucker, Aloyce Kisoli, Jane Cletus, Carolyn Lissu, Kajiru Kilonzo, Glynis Cosker, Elizabeta Blagoja Mukaetova-Ladinska, Catherine Dotchin, William Gray, Richard Walker, Sarah Urasa
BACKGROUND: The risk factors for prevalent delirium in older hospitalised adults in Sub-Saharan Africa (SSA) remain poorly characterised. METHODS: A total of 510 consecutive admissions of adults aged ≥60 years to acute medical wards of Kilimanjaro Christian Medical Centre in northern Tanzania were recruited. Patients were assessed within 24 h of admission with a risk factor questionnaire, physiological observations, neurocognitive assessment, and informant interview...
September 5, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28848214/cortical-functional-connections-and-fluid-intelligence-in-adolescent-apoe-%C3%AE%C2%B54-carriers
#9
Minjung Woo, Yujin Kim
AIMS: This study examined differences in corticocortical communication between adolescent ε4 carriers (ε4+) and noncarriers (ε4-) during a fluid intelligence task (Comprehensive Test of Nonverbal Intelligence [CTONI]). METHODS: Sixteen ε4+ and 20 ε4- individuals aged 13-15 years performed the CTONI while real-time EEG signals were acquired. Inter- and intrahemispheric coherences were analyzed. RESULTS: The ε4+ subjects exhibited lower inter- and intrahemispheric coherences than the ε4- individuals...
August 24, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28848086/cerebrospinal-fluid-tar-dna-binding-protein-43-combined-with-tau-proteins-as-a-candidate-biomarker-for-amyotrophic-lateral-sclerosis-and-frontotemporal-dementia-spectrum-disorders
#10
Mara Bourbouli, Michael Rentzos, Anastasia Bougea, Vasiliki Zouvelou, Vasilios C Constantinides, Ioannis Zaganas, Ioannis Evdokimidis, Elisabeth Kapaki, George P Paraskevas
BACKGROUND: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are nowadays recognized as spectrum disorders with a molecular link, the TAR DNA-binding protein 43 (TDP-43), rendering it a surrogate biomarker for these disorders. METHODS: We measured cerebrospinal fluid (CSF) levels of TDP-43, beta-amyloid peptide with 42 amino acids (Aβ42), total tau protein (τT), and tau protein phosphorylated at threonine 181 (τP-181) in 32 patients with ALS, 51 patients with FTD, and 17 healthy controls...
August 23, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28787730/characterisation-of-positive-behaviours-in-primary-progressive-aphasias
#11
Akira Midorikawa, Fiona Kumfor, Cristian E Leyton, David Foxe, Ramon Landin-Romero, John R Hodges, Olivier Piguet
BACKGROUND/AIMS: Although some patients with primary progressive aphasia (PPA) exhibit novel or improved skills after the onset of dementia, these changes have yet to be quantified. Therefore, this study systematically explored and identified the emergence of positive behaviours after dementia onset. METHODS: This study included 48 carers of patients with PPA: 12 nonfluent/agrammatic PPA (nfvPPA), 22 semantic variant PPA (svPPA), and 14 logopenic variant PPA (lvPPA)...
August 5, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28787712/effectiveness-of-florbetapir-pet-imaging-in-changing-patient-management
#12
Michael J Pontecorvo, Andrew Siderowf, Bruno Dubois, P Murali Doraiswamy, Giovanni B Frisoni, Michael Grundman, Flavio Nobili, Carl H Sadowsky, Stephen Salloway, Anupa K Arora, Antoine Chevrette, Walter Deberdt, Grazia Dell'Agnello, Matthew Flitter, Nick Galante, Mark J Lowrey, Ming Lu, Anne McGeehan, Michael D Devous, Mark A Mintun
AIMS: To evaluate the impact of amyloid PET imaging on diagnosis and patient management in a multicenter, randomized, controlled study. METHODS: Physicians identified patients seeking a diagnosis for mild cognitive impairment or dementia, possibly due to Alzheimer disease (AD), and recorded a working diagnosis and a management plan. The patients underwent florbetapir PET scanning and were randomized to either immediate or delayed (1-year) feedback regarding amyloid status...
August 5, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29207387/comparative-effects-of-education-and-bilingualism-on-the-onset-of-mild-cognitive-impairment
#13
Subasree Ramakrishnan, Shailaja Mekala, Annapurna Mamidipudi, Sireesha Yareeda, Rukmini Mridula, Thomas H Bak, Suvarna Alladi, Subhash Kaul
BACKGROUND: Increasing evidence suggests that life course factors such as education and bilingualism may have a protective role against dementia due to Alzheimer disease. This study aimed to compare the effects of education and bilingualism on the onset of cognitive decline at the stage of mild cognitive impairment (MCI). METHODS: A total of 115 patients with MCI evaluated in a specialty memory clinic in Hyderabad, India, formed the cohort. MCI was diagnosed according to Petersen's criteria following clinical evaluation and brain imaging...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28768251/a-randomized-controlled-trial-examining-the-effect-of-acupressure-on-agitation-and-salivary-cortisol-in-nursing-home-residents-with-dementia
#14
Rick Yiu Cho Kwan, Mason Chin Pang Leung, Claudia Kam Yuk Lai
BACKGROUND: Acupressure has been used to manage agitation in people with dementia because it is safe and inexpensive. However, its effect on agitation and at the biochemical level is uncertain. METHODS: This randomized controlled trial examined the effect of acupressure on agitation, as measured by the Cohen-Mansfield Agitation Inventory (CMAI); and on salivary cortisol, as measured at baseline (T0) and in the 3rd (T1), 5th (T2), and 8th (T3) weeks. There were 119 agitated residents with dementia randomized into 3 groups: acupressure (n = 39), sham (n = 41), and usual-care group (n = 39)...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28768247/tracking-cognitive-decline-in-amnestic-mild-cognitive-impairment-and-early-stage-alzheimer-dementia-mini-mental-state-examination-versus-neuropsychological-battery
#15
Joonho Kim, Han Kyu Na, Justin Byun, Jiwon Shin, Sungsoo Kim, Byung Hwa Lee, Duk L Na
BACKGROUND/AIMS: Although the Mini-Mental State Examination (MMSE), Clinical Dementia Rating-Sum of Boxes (CDR-SOB), and neuropsychological batteries are widely used for evaluating cognitive function, it remains elusive which instrument best reflects the longitudinal disease progression in amnestic mild cognitive impairment (aMCI) and probable Alzheimer disease (AD). We investigated whether changes in these three instruments over time correlate with loss of cortical gray matter volume (cGMV)...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28743108/high-density-lipoprotein-cholesterol-level-relates-to-working-memory-immediate-and-delayed-cued-recall-in-brazilian-older-adults-the-role-of-cognitive-reserve
#16
Andreas Ihle, Élvio R Gouveia, Bruna R Gouveia, Duarte L Freitas, Jefferson Jurema, Maria A Tinôco, Matthias Kliegel
AIMS: The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. METHODS: We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28738363/mild-cognitive-impairment-and-driving-cessation-a-3-year-longitudinal-study
#17
Michael H Connors, David Ames, Michael Woodward, Henry Brodaty
BACKGROUND/AIMS: Driving cessation is associated with significant morbidity in older people. People with mild cognitive impairment (MCI) may be at particular risk of this. Very little research has examined driving in this population. Given this, we sought to identify predictors of driving cessation in people with MCI. METHODS: One hundred and eighty-five people with MCI were recruited from 9 memory clinics around Australia. People with MCI and their carers reported their driving status and completed measures of cognition, function, neuropsychiatric symptoms, and medication use at regular intervals over a 3-year period...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28738341/unmet-care-needs-in-the-oldest-old-primary-care-patients-with-cognitive-disorders-results-of-the-agecode-and-agequalide-study
#18
Janine Stein, Alexander Pabst, Tobias Luck, Dagmar Lühmann, Kathrin Heser, Frank Jessen, Horst Bickel, Edelgard Mösch, Michael Pentzek, Angela Fuchs, Birgitt Wiese, Silke Mamone, Hans-Helmut König, Christian Brettschneider, Jochen Werle, Martin Scherer, Wolfgang Maier, Siegfried Weyerer, Steffi G Riedel-Heller
BACKGROUND: In the future, an increase in health care needs in the elderly is expected. Reports on unmet care needs of the oldest old with cognitive disorders are pending. This study aims at exploring unmet needs in the oldest old primary care patients with mild cognitive impairment (MCI) and dementia. Furthermore, the association between sociodemographic and clinical factors and unmet needs ought to be analyzed. METHODS: Based on the study "Needs, Health Service Use, Costs and Health-Related Quality of Life in a Large Sample of Oldest-Old Primary Care Patients (85+)" (AgeQualiDe), 749 patients (unimpaired, MCI, and dementia) aged 85 years and older, their relatives (n = 421), and general practitioners (GPs) (n = 607) were assessed...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28738338/cognitive-impairment-is-reflected-by-an-increased-difference-between-real-and-imagined-timed-up-and-go-test-performance
#19
Stefanie Rüdiger, Tim Stuckenschneider, Tobias Vogt, Vera Abeln, Brian Lawlor, Marcel Olde Rikkert, Stefan Schneider
BACKGROUND: Recent research suggests using an imaginary version of the Timed Up and Go test (TUG) for a first assessment of cognitive impairment. By using the time difference between a real (TUGr) and an imagined (TUGi) TUG task, the objective of this study was to examine the effect of cognitive impairment on motor imagery ability. METHODS: Fifty-two participants (mean age 69.3 ± 4.0 years) with mild cognitive impairment or subjective cognitive impairment were included in this study...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28675901/visual-ratings-of-medial-temporal-lobe-atrophy-correlate-with-csf-tau-indices-in-clinical-variants-of-early-onset-alzheimer-disease
#20
Elias Granadillo, Pongsatorn Paholpak, Mario F Mendez, Edmond Teng
BACKGROUND/AIMS: Prior studies of late-onset Alzheimer disease (AD) have reported that cerebrospinal fluid (CSF) tau levels correlate with hippocampal/medial temporal lobe atrophy. These findings suggest that CSF tau indices in AD may reflect tau-related neurodegeneration in the medial temporal lobe. However, it remains uncertain whether elevated CSF tau levels in the clinically heterogeneous subtypes of early-onset AD (EOAD; amnestic, posterior cortical atrophy [PCA], and logopenic progressive aphasia [LPA]) are attributable to similar underlying mechanisms...
2017: Dementia and Geriatric Cognitive Disorders
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