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Dementia and Geriatric Cognitive Disorders

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https://www.readbyqxmd.com/read/28222439/trajectories-of-depression-in-late-life-a-1-year-follow-up-study
#1
Tom Borza, Knut Engedal, Sverre Bergh, Jūratė Šaltytė Benth, Geir Selbæk
AIMS: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. METHODS: We performed an observational, multicenter, longitudinal study of 160 patients aged ≥60 years who were admitted to inward treatment of DLL. The patients were followed with 3 assessments: at inclusion (T0), at discharge from the hospital (T1), and after 1 year (T2). Growth mixture modeling was applied to identify patient classes following distinct trajectories of the Montgomery-Åsberg Depression Rating Scale (MADRS) score...
February 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28199994/association-between-montreal-cognitive-assessment-sub-item-scores-and-corresponding-cognitive-test-performance-in-patients-with-frontotemporal-dementia-and-related-disorders
#2
Kristy K L Coleman, Brenda L Coleman, Julia D MacKinley, Stephen H Pasternak, Elizabeth C Finger
The Montreal Cognitive Assessment (MoCA), a brief screening test developed to detect patients with mild cognitive impairment, is used in clinical settings across North America [Nasreddine et al.: J Am Geriatr Soc 2005;53:695-699]. The MoCA has been demonstrated to be sensitive to cognitive deficits in frontotemporal dementias (FTD) and related disorders [Coleman et al.: Alzheimer Dis Assoc Disord 2016;30:258-263]. Given attentional impairments in patients with FTD, whether and to what extent the abbreviated items on the MoCA may predict performance on corresponding assessments is not known...
February 16, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28178703/the-impact-of-depression-on-the-development-of-mild-cognitive-impairment-over-3-years-of-follow-up-a-population-based-study
#3
Elvira Lara, Ai Koyanagi, Joan Domènech-Abella, Marta Miret, Jose Luis Ayuso-Mateos, Josep Maria Haro
BACKGROUND/AIMS: In the absence of effective treatments for dementia, major efforts are being directed towards identifying the risk factors of the prodromal phase of the disease. We report the incidence rates of mild cognitive impairment (MCI) in a Spanish population sample and assess the effect of depression at baseline on incident MCI (or MCI subtypes) at a 3-year follow-up. METHODS: A total of 1,642 participants (age ≥50 years) were examined as part of a Spanish nationally representative longitudinal study...
February 9, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28152536/convergent-results-from-neuropsychology-and-from-neuroimaging-in-patients-with-mild-cognitive-impairment
#4
Carl Fredrik Eliassen, Ivar Reinvang, Per Selnes, Tormod Fladby, Erik Hessen
BACKGROUND/AIMS: To investigate the correspondence between neuropsychological single measures and variation in fludeoxyglucose positron emission tomography (FDG PET) glucose metabolism and magnetic resonance imaging (MRI) cortical thickness in mild cognitive impairment (MCI) patients. METHODS: Forty-two elderly controls and 73 MCI subjects underwent FDG PET and MRI scanning. Backward regression analyses with PET and MRI regions were used as dependent variables, while Rey Auditory Verbal Memory Test (RAVLT) recall, Trail Making Test B (TMT B), and a composite test score (RAVLT learning and immediate recall, TMT A, COWAT, and letter-number sequencing) were used as predictor variables...
February 3, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28152532/association-between-various-brain-pathologies-and-gait-disturbance
#5
Alexandra M V Wennberg, Rodolfo Savica, Michelle M Mielke
BACKGROUND: Approximately 30% of older adults have disrupted gait. It is associated with increased risk of cognitive decline, disability, dementia, and death. Additionally, most older adults present with 1 or more neuropathologies at autopsy. Recently, there has been an effort to investigate the association between subclinical neuropathology and gait. SUMMARY: We reviewed studies that investigated the association between gait and neuropathologies. Although all pathologies reviewed were associated with gait, grey matter atrophy was most consistently linked with poorer gait performance...
February 3, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28142142/the-rs1277306-variant-of-the-rest-gene-confers-susceptibility-to-cognitive-aging-in-an-elderly-taiwanese-population
#6
Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Cheng-Hung Yang
BACKGROUND/AIMS: There is growing evidence that the RE1-silencing transcription factor (REST) gene may contribute to cognitive aging and Alzheimer diseases. In this replication study, we reassessed whether single nucleotide polymorphisms (SNPs) within the REST gene are linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population. METHODS: A total of 634 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed...
February 1, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28122366/comprehensive-individualized-person-centered-management-of-community-residing-persons-with-moderate-to-severe-alzheimer-disease-a-randomized-controlled-trial
#7
Barry Reisberg, Yongzhao Shao, James Golomb, Isabel Monteiro, Carol Torossian, Istvan Boksay, Melanie Shulman, Sloane Heller, Zhaoyin Zhu, Ayesha Atif, Jaskirat Sidhu, Alok Vedvyas, Sunnie Kenowsky
BACKGROUND/AIMS: The aim was to examine added benefits of a Comprehensive, Individualized, Person-Centered Management (CI-PCM) program to memantine treatment. METHODS: This was a 28-week, clinician-blinded, randomized, controlled, parallel-group study, with a similar study population, similar eligibility criteria, and a similar design to the memantine pivotal trial of Reisberg et al. [N Engl J Med 2003;348:1333-1341]. Twenty eligible community-residing Alzheimer disease (AD) subject-caregiver dyads were randomized to the CI-PCM program (n = 10) or to usual community care (n = 10)...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28103593/executive-dysfunction-and-behavioral-symptoms-are-associated-with-deficits-in-instrumental-activities-of-daily-living-in-frontotemporal-dementia
#8
Negar Moheb, Mario F Mendez, Sarah A Kremen, Edmond Teng
BACKGROUND: Deficits in instrumental activities of daily living (ADLs) may be more prominent in behavioral variant frontotemporal dementia (bvFTD) than in nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) or semantic variant primary progressive aphasia (svPPA). It is uncertain whether frontotemporal dementia (FTD) subgroups exhibit different patterns and/or predictors of functional impairment. METHODS: We examined data from participants diagnosed with bvFTD (n = 607), svPPA (n = 132), and nfvPPA (n = 155) who were included in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) and assessed with the Functional Activities Questionnaire (FAQ)...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28095376/review-of-decision-making-in-game-tasks-in-elderly-participants-with-alzheimer-disease-and-mild-cognitive-impairment
#9
Alaise Silva Santos de Siqueira, Juliana Emy Yokomizo, Wilson Jacob-Filho, Mônica Sanches Yassuda, Ivan Aprahamian
BACKGROUND: Changes in decision-making (DM) have recently been investigated in patients with Alzheimer disease (AD) or mild cognitive impairment (MCI). DM is highly relevant to everyday functioning and autonomy. It relies on several cognitive abilities, such as semantic and episodic memory, as well as aspects of executive functioning. We conducted a systematic review of DM in older adults with MCI and AD. SUMMARY: Only 5 studies whose main objective was to evaluate the DM performance were selected...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28056460/cerebrospinal-fluid-biomarker-based-diagnosis-of-sporadic-creutzfeldt-jakob-disease-a-validation-study-for-previously-established-cutoffs
#10
Franc Llorens, André Karch, Ewa Golanska, Matthias Schmitz, Peter Lange, Beata Sikorska, Pawel P Liberski, Inga Zerr
BACKGROUND: Several biomarkers have been proposed to discriminate sporadic Creutzfeldt-Jakob disease (sCJD) from other dementias and control cases. However, their clinical accuracy depends on the PRNP codon 129 genotype, leaving it unclear how well established markers behave in untested conditions. METHODS: We analyzed 14-3-3, tau, p-tau levels, and the p-tau/tau ratio in a population sample collected from Polish hospitals including nondementia, dementia, and definite sCJD cases and validated their parameters according to previously established cutoffs...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28013307/why-almost-always-animals-ranking-fluency-tasks-for-the-detection-of-dementia-based-on-receiver-operating-characteristic-roc-and-quality-roc-analyses
#11
F Javier Moreno-Martínez, Marcos Ruiz, Pedro R Montoro
BACKGROUND/AIMS: Category fluency tasks have been widely used to assess cognitive functioning in both clinical and experimental environments as an index of cognitive and psycholinguistic dysfunctions in dementia. Typically, a reduced group of semantic categories has been selected for neuropsychological assessment (e.g., animals, fruits or vegetables), although empirical support for the prevalence of one category among others is absent in the literature. METHODS: We provide an empirical evaluation of the ability of 14 category fluency tasks to discriminate between subjects with dementia of the Alzheimer type and healthy elderly participants...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27988521/inhibitors-of-acetylcholinesterase-derived-from-7-methoxytacrine-and-their-effects-on-the-choline-transporter-cht1
#12
Zdenka Kristofikova, Jan Ricny, Ondrej Soukup, Jan Korabecny, Eugenie Nepovimova, Kamil Kuca, Daniela Ripova
BACKGROUND: Reversible acetylcholinesterase inhibitors are used in Alzheimer disease therapy. However, tacrine and its derivatives have severe side effects. Derivatives of the tacrine analogue 7-methoxytacrine (MEOTA) are less toxic. METHODS: We evaluated new derivatives of 7-MEOTA (2 homodimers linked by 2 C4-C5 chains and 5 N-alkylated C4-C8 side chain derivatives) in vitro, using the rat hippocampal choline transporter CHT1. RESULTS: Some derivatives were effective inhibitors of rat acetylcholinesterase and comparable with 7-MEOTA...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27978516/prognostic-significance-of-dementia-in-older-adults-with-solid-tumors
#13
Supakanya Wongrakpanich, Amy Hurst, Jean Bustamante, Nellowe Candelario, Sylvia Biso, Wikrom Chaiwatcharayut, Claudia Dourado, Andrew Rosenzweig
BACKGROUND: The public health burden of cancer and dementia in the geriatric population is well documented. There is limited data on how dementia predicts mortality among geriatric patients with solid tumors. The objective of this study is to determine the prognostic significance of dementia on survival in patients with solid tumors. METHODS: We performed a 5-year retrospective study on elderly subjects aged ≥60 years with and without dementia that were diagnosed with solid tumors...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27974719/acetylcholinesterase-activity-measurement-and-clinical-features-of-delirium
#14
Thomas A Jackson, Hannah C Moorey, Bart Sheehan, Alasdair M J Maclullich, John R Gladman, Janet M Lord
AIMS: Cholinergic deficiency is commonly implicated in the pathophysiology of delirium. We aimed to investigate the relationship between directly measured serum acetylcholinesterase (AChE) activity and (1) clinical features of delirium and (2) outcomes among older hospital patients with delirium. METHODS: Hospitalised patients with delirium were recruited, and delirium motor subtype, severity and duration of delirium were measured. Serum AChE activity was measured using a colorimetric assay...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27907913/screening-younger-individuals-in-a-primary-care-setting-flags-putative-dementia-cases-and-correlates-gastrointestinal-diseases-with-poor-cognitive-performance
#15
Ilka M Rosa, Ana Gabriela Henriques, Liliana Carvalho, Joana Oliveira, Odete A B da Cruz E Silva
BACKGROUND/AIMS: Diagnosing dementia is challenging in many primary care settings, given the limited human resources and the lack of current diagnostic tools. With this in mind, a primary care-based cohort was established in the Aveiro district of Portugal. METHODS: A total of 568 participants were evaluated using cognitive tests and APOE genotyping. RESULTS: The findings revealed a dementia prevalence of 12%. A strong correlation between increasing Clinical Dementia Rating (CDR) scores and education was clearly evident...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27889770/usefulness-of-discriminability-and-response-bias-indices-for-the-evaluation-of-recognition-memory-in-mild-cognitive-impairment-and-alzheimer-disease
#16
María Julieta Russo, Gabriela Cohen, Jorge Campos, Maria Eugenia Martin, María Florencia Clarens, Liliana Sabe, Ernesto Barcelo, Ricardo F Allegri
BACKGROUND: Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE: To evaluate the recognition memory performance by using a yes/no procedure to examine the effect of discriminability and response bias measures in amnestic mild cognitive impairment (a-MCI), AD dementia, and normal-aging subjects...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27669054/factors-of-resilience-in-informal-caregivers-of-people-with-dementia-from-integrative-international-data-analysis
#17
Karlijn J Joling, Gill Windle, Rose-Marie Dröes, Franka Meiland, Hein P J van Hout, Janet MacNeil Vroomen, Peter M van de Ven, Esmé Moniz-Cook, Bob Woods
BACKGROUND/AIMS: Although caring for a person with dementia can be stressful, some caregivers appear to experience few negative consequences to their well-being. This study aimed to examine what proportion of caregivers demonstrates resilience under different challenging circumstances and to identify factors related to their resilience. METHODS: Baseline data from 4 studies from the Netherlands and UK among informal caregivers of people with dementia were harmonized and integrated...
September 27, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27649316/cognitive-function-apoe-gene-polymorphisms-and-thyroid-status-associations-in-postmenopausal-women-in-poland
#18
Iwona Bojar, Magdalena Stasiak, Anna Cyniak-Magierska, Dorota Raczkiewicz, Andrzej Lewiński
BACKGROUND: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). METHODS: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms...
September 21, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27643700/fine-motor-function-skills-in-patients-with-parkinson-disease-with-and-without-mild-cognitive-impairment
#19
Philippe Dahdal, Antonia Meyer, Chaturvedi Menorca, Karolina Nowak, Anne D Roesch, Peter Fuhr, Ute Gschwandtner
AIMS: The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS: Twenty PD MCI and 31 PD non-MCI patients (mean age 66.7 years, range 50-84, 36 males/15 females), all right-handed, took part in a motor performance test battery...
September 20, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27866203/frontal-assessment-battery-as-a-useful-tool-to-differentiate-mild-cognitive-impairment-due-to-subcortical-ischemic-vascular-disease-from-alzheimer-disease
#20
Yen-Hsuan Hsu, Ching-Feng Huang, Chung-Ping Lo, Tzu-Lan Wang, Chi-Cheng Yang, Min-Chien Tu
BACKGROUND: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have yet to be clarified. METHODS: Patients with mild cognitive impairment (MCI) due to SIVD (MCI-V), MCI due to AD (MCI-A), and demographically matched controls completed the Mini-Mental State Examination, Taiwanese FAB (TFAB), Category Fluency, and Chinese Version of the Verbal Learning Test, and underwent magnetic resonance imaging...
2016: Dementia and Geriatric Cognitive Disorders
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