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Dementia and Geriatric Cognitive Disorders

journal
https://www.readbyqxmd.com/read/27907913/screening-younger-individuals-in-a-primary-care-setting-flags-putative-dementia-cases-and-correlates-gastrointestinal-diseases-with-poor-cognitive-performance
#1
Ilka M Rosa, Ana Gabriela Henriques, Liliana Carvalho, Joana Oliveira, Odete A B da Cruz E Silva
BACKGROUND/AIMS: Diagnosing dementia is challenging in many primary care settings, given the limited human resources and the lack of current diagnostic tools. With this in mind, a primary care-based cohort was established in the Aveiro district of Portugal. METHODS: A total of 568 participants were evaluated using cognitive tests and APOE genotyping. RESULTS: The findings revealed a dementia prevalence of 12%. A strong correlation between increasing Clinical Dementia Rating (CDR) scores and education was clearly evident...
December 2, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27889770/usefulness-of-discriminability-and-response-bias-indices-for-the-evaluation-of-recognition-memory-in-mild-cognitive-impairment-and-alzheimer-disease
#2
María Julieta Russo, Gabriela Cohen, Jorge Campos, Maria Eugenia Martin, María Florencia Clarens, Liliana Sabe, Ernesto Barcelo, Ricardo F Allegri
BACKGROUND: Most studies examining episodic memory in Alzheimer disease (AD) have focused on patients' impaired ability to remember information. This approach provides only a partial picture of memory deficits since other factors involved are not considered. OBJECTIVE: To evaluate the recognition memory performance by using a yes/no procedure to examine the effect of discriminability and response bias measures in amnestic mild cognitive impairment (a-MCI), AD dementia, and normal-aging subjects...
November 26, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27669054/factors-of-resilience-in-informal-caregivers-of-people-with-dementia-from-integrative-international-data-analysis
#3
Karlijn J Joling, Gill Windle, Rose-Marie Dröes, Franka Meiland, Hein P J van Hout, Janet MacNeil Vroomen, Peter M van de Ven, Esmé Moniz-Cook, Bob Woods
BACKGROUND/AIMS: Although caring for a person with dementia can be stressful, some caregivers appear to experience few negative consequences to their well-being. This study aimed to examine what proportion of caregivers demonstrates resilience under different challenging circumstances and to identify factors related to their resilience. METHODS: Baseline data from 4 studies from the Netherlands and UK among informal caregivers of people with dementia were harmonized and integrated...
September 27, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27649316/cognitive-function-apoe-gene-polymorphisms-and-thyroid-status-associations-in-postmenopausal-women-in-poland
#4
Iwona Bojar, Magdalena Stasiak, Anna Cyniak-Magierska, Dorota Raczkiewicz, Andrzej Lewiński
BACKGROUND: The objective of the study was to analyze a potential association between cognitive functions and thyroid status in postmenopausal women with different polymorphisms of the apolipoprotein E gene (APOE). METHODS: The examined population included 402 postmenopausal women from south-eastern Poland. The evaluation of cognitive functions was made with the use of the diagnostic Central Nervous System-Vital Signs equipment (Polish version). Multiplex polymerase chain reactions were performed to assess APOE polymorphisms...
September 21, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27649085/white-matter-lesions-prevalence-and-clinical-phenotype-in-asymptomatic-individuals-aged-%C3%A2-50-years
#5
Jean-Philippe David, Emilie Ferrat, Juliette Parisot, Henri Naga, Samia Lakroun, Feriel Menasria, Sofiane Saddedine, Pierre-André Natella, Elena Paillaud, Isabelle Fromentin, Sylvie Bastuji-Garin
BACKGROUND: To assess the prevalence of early confluent/confluent white matter lesions (ec/cWMLs) in asymptomatic individuals aged ≥50 years and to identify associated clinical phenotypes. METHODS: Cross-sectional analysis of 141 asymptomatic individuals aged ≥50 years assessed at an outpatient department in France. Brain magnetic resonance imaging was rated using the Fazekas scale. Age-adjusted odds ratios (ORs) and 95% confidence intervals were estimated using logistic models to investigate factors associated with ec/cWMLs; independent risk factors were identified by multivariate analysis...
September 21, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27643858/cerebrospinal-fluid-amyloid-beta-and-tau-concentrations-are-not-modulated-by-16-weeks-of-moderate-to-high-intensity-physical-exercise-in-patients-with-alzheimer-disease
#6
Camilla Steen Jensen, Erik Portelius, Volkert Siersma, Peter Høgh, Lene Wermuth, Kaj Blennow, Henrik Zetterberg, Gunhild Waldemar, Steen Gregers Hasselbalch, Anja Hviid Simonsen
BACKGROUND: Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies have shown that amyloid beta (Aβ), one of the pathological hallmarks of AD, can be altered with high levels of physical activity. AIM: The objective of this study was to elucidate the effect of 16 weeks of moderate- to high-intensity physical exercise on the biomarkers of AD, with special emphasis on the amyloidogenic pathway...
September 20, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27643700/fine-motor-function-skills-in-patients-with-parkinson-disease-with-and-without-mild-cognitive-impairment
#7
Philippe Dahdal, Antonia Meyer, Chaturvedi Menorca, Karolina Nowak, Anne D Roesch, Peter Fuhr, Ute Gschwandtner
AIMS: The objective of this study was to investigate the relation between impaired fine motor skills in Parkinson disease (PD) patients and their cognitive status, and to determine whether fine motor skills are more impaired in PD patients with mild cognitive impairment (MCI) than in non-MCI patients. METHODS: Twenty PD MCI and 31 PD non-MCI patients (mean age 66.7 years, range 50-84, 36 males/15 females), all right-handed, took part in a motor performance test battery...
September 20, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27866203/frontal-assessment-battery-as-a-useful-tool-to-differentiate-mild-cognitive-impairment-due-to-subcortical-ischemic-vascular-disease-from-alzheimer-disease
#8
Yen-Hsuan Hsu, Ching-Feng Huang, Chung-Ping Lo, Tzu-Lan Wang, Chi-Cheng Yang, Min-Chien Tu
BACKGROUND: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have yet to be clarified. METHODS: Patients with mild cognitive impairment (MCI) due to SIVD (MCI-V), MCI due to AD (MCI-A), and demographically matched controls completed the Mini-Mental State Examination, Taiwanese FAB (TFAB), Category Fluency, and Chinese Version of the Verbal Learning Test, and underwent magnetic resonance imaging...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27866199/the-experience-of-relations-in-persons-with-dementia-a-systematic-meta-synthesis
#9
Siren Eriksen, Anne-Sofie Helvik, Lene Kristin Juvet, Kirsti Skovdahl, Linn Hege Førsund, Ellen Karine Grov
BACKGROUND: Dementia influences a person's experience of social relationships, as described in several studies. In this systematic meta-synthesis of qualitative studies, we aim to interpret and synthesize the experiences of persons with dementias and their relations with others. SUMMARY: Living with dementia changes life, leading to new social roles and different social statuses. Persons with dementia experience being disconnected and dependent on others, feeling like being a burden, and being a person who is treated in paternalistic ways...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27811466/symptoms-of-anxiety-in-older-adults-with-depression-dementia-or-psychosis-a-principal-component-analysis-of-the-geriatric-anxiety-inventory
#10
Anette Bakkane Bendixen, Cecilie Bhandari Hartberg, Geir Selbæk, Knut Engedal
AIMS: The primary aim of this study was to examine anxiety symptoms as measured by the Geriatric Anxiety Inventory (GAI) in older patients with depression, dementia, or psychotic disorders. The secondary aim was to conduct a principal component analysis (PCA) of the GAI and to examine whether its subscales differ between the 3 disorders. METHODS: We included data from 428 patients who were admitted to a department of geriatric psychiatry and examined according to a standardized protocol...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27811463/screening-for-dementia-in-primary-care-a-comparison-of-the-gpcog-and-the-mmse
#11
Henry Brodaty, Michael H Connors, Clement Loy, Armando Teixeira-Pinto, Nigel Stocks, Jane Gunn, Karen E Mate, C Dimity Pond
BACKGROUND/AIMS: The General Practitioner Assessment of Cognition (GPCOG) is a brief cognitive test. This study compared the GPCOG to the Mini-Mental State Examination (MMSE), the most widely used test, in terms of their ability to detect likely dementia in primary care. METHODS: General practitioners across three states in Australia recruited 2,028 elderly patients from the community. A research nurse administered the GPCOG and the MMSE, as well as the Cambridge Examination for Mental Disorders of the Elderly Cognitive Scale-Revised that we used to define likely dementia...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27802435/blood-based-oxidative-stress-markers-and-cognitive-performance-in-early-old-age-the-hapiee-study
#12
Pia Horvat, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Ben Schöttker, Hynek Pikhart, Anne Peasey, Magdalena Kozela, Eugene Jansen, Archana Singh-Manoux, Martin Bobak
BACKGROUND/AIMS: Oxidative stress is involved in Alzheimer disease pathology, but its impact on cognitive function in community-dwelling older adults remains unknown. We estimated associations between serum oxidative stress markers and cognitive function in early old age. METHODS: Subjects aged 45-69 years recruited in urban centers in Central and Eastern Europe had memory, verbal fluency, and processing speed assessed at baseline (2002-2005) and 3 years later. Derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and total thiol levels (TTLs) were measured at baseline in a subsample...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27784013/reduced-frontal-activations-at-high-working-memory-load-in-mild-cognitive-impairment-near-infrared-spectroscopy
#13
Michael K Yeung, Sophia L Sze, Jean Woo, Timothy Kwok, David H K Shum, Ruby Yu, Agnes S Chan
BACKGROUND: Some functional magnetic resonance imaging studies have reported altered activations in the frontal cortex during working memory (WM) performance in individuals with mild cognitive impairment (MCI), but the findings have been mixed. The objective of the present study was to utilize near-infrared spectroscopy (NIRS), an alternative imaging technique, to examine neural processing during WM performance in individuals with MCI. METHODS: Twenty-six older adults with MCI (7 males; mean age 69...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27723653/the-relational-and-item-specific-encoding-task-in-mild-cognitive-impairment-and-alzheimer-disease
#14
Amber Sousa, Jesus J Gomar, J Daniel Ragland, Concepcion Conejero-Goldberg, Justin Buthorn, Lynda Keehlisen, Ted E Huey, Jeremy Koppel, Marc L Gordon, Erica Christen, Terry E Goldberg
BACKGROUND: The Relational and Item-Specific Encoding task (RISE) measures episodic memory subcomponents, including item-specific and relational encoding of to-be-remembered stimuli. These memory components are neurobiologically relevant because they may engage distinct subregions of the medial temporal lobe, perirhinal and entorhinal cortices, parahippocampus, and hippocampus. METHODS: A total of 125 participants, including 84 healthy controls (HC), 22 mild cognitive impairment-diagnosed and 19 Alzheimer disease (AD)-diagnosed participants, were administered the RISE and neuropsychological measures...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27705978/correlation-or-limits-of-agreement-applying-the-bland-altman-approach-to-the-comparison-of-cognitive-screening-instruments
#15
A J Larner
BACKGROUND/AIMS: Calculation of correlation coefficients is often undertaken as a way of comparing different cognitive screening instruments (CSIs). However, test scores may correlate but not agree, and high correlation may mask lack of agreement between scores. The aim of this study was to use the methodology of Bland and Altman to calculate limits of agreement between the scores of selected CSIs and contrast the findings with Pearson's product moment correlation coefficients between the test scores of the same instruments...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27705964/interaction-with-the-mapt-h1h1-genotype-increases-dementia-risk-in-apoe-%C3%AE%C2%B54-carriers-in-a-population-of-southern-india
#16
P S Jairani, P M Aswathy, Srinivas Gopala, Joe Verghese, P S Mathuranath
BACKGROUND: This study delineates the role of the interaction of apolipoprotein E (APOE) and MAPT alleles in contributing to disease risks of dementia in a southern Indian population. METHODS: A sample of 419 patients comprising Alzheimer's disease (AD; n = 156), mild cognitive impairment (MCI; n = 87), frontotemporal dementia (FTD; n = 127), vascular dementia (VD; n = 37), and dementia with Lewy bodies (DLB; n = 12) was analysed in comparison with a control group (n = 138)...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27701163/white-matter-changes-may-precede-gray-matter-loss-in-elderly-with-subjective-memory-impairment
#17
Yun Jeong Hong, Chan-Mi Kim, Eun Hye Jang, Jihye Hwang, Jee Hoon Roh, Jae-Hong Lee
BACKGROUND/AIMS: A limited number of studies addressed MRI-based neurodegenerative changes in subjective memory impairment (SMI). We investigated changes in white matter (WM) microstructures as well as gray matter (GM) macrostructures in subjects with SMI of high and low risk for progression. METHODS: A modeling scale (score range, 0-6) developed for prediction of SMI progression was used to divide SMI subjects (n = 46) into two groups: a high risk of progression (score ≥3; n = 19) and a low risk of progression (score ≤2; n = 27)...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27701160/cognitive-impairment-is-associated-with-a-low-omega-3-index-in-the-elderly-results-from-the-kora-age-study
#18
Karoline Lukaschek, Clemens von Schacky, Johannes Kruse, Karl-Heinz Ladwig
BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFA) may affect the risk of cognitive decline in older adults. METHODS: Cross-sectional analysis was conducted among 720 (50.4% women) participants aged 68-92 years (mean age: 77.6, SD ±6.2) of the population-based KORA-Age study. Eicosapentaenoic acid and docosahexaenoic acid (omega-3 index) were measured in erythrocytes as a percentage of total fatty acids. The categories low (<5.7), intermediate (5.7-6.8), and high (>6...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27684067/the-relationship-between-behavioural-changes-cognitive-symptoms-and-functional-disability-in-primary-progressive-aphasia-a-longitudinal-study
#19
Claire M O'Connor, Lindy Clemson, Emma Flanagan, Cassandra Kaizik, Henry Brodaty, John R Hodges, Olivier Piguet, Eneida Mioshi
BACKGROUND: The contribution of behavioural changes to functional decline is yet to be explored in primary progressive aphasia (PPA). OBJECTIVES: (1) investigate functional changes in two PPA variants [semantic (svPPA) and non-fluent (nfvPPA)], at baseline and after 12 months; (2) investigate baseline differences in behavioural changes between groups, and (3) explore predictors of functional decline after a 12-month period. METHODS: A longitudinal study involving 29 people with PPA (18 svPPA; 11 nfvPPA) seen annually in Sydney/Australia was conducted...
2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27668927/characteristics-associated-with-quality-of-life-in-long-term-care-residents-with-dementia-a-cross-sectional-study
#20
Maartje S Klapwijk, Monique A A Caljouw, Marjoleine J C Pieper, Jenny T van der Steen, Wilco P Achterberg
BACKGROUND: To determine which characteristics are associated with quality of life (QOL) in residents with moderate to very severe dementia in long-term care facilities (LTCFs). MATERIAL AND METHODS: This was a cross-sectional analysis of a cluster randomized controlled study in 12 Dutch LTCFs that enrolled 288 residents, with moderate to severe dementia assessed with the Reisberg Global Deterioration Scale (Reisberg GDS) and QOL with the QUALIDEM. Characteristics that were hypothesized to be associated with the six domains of QOL (applicable to very severe dementia) included demographic variables, activities of daily living (Katz ADL), cognitive performance (Cognitive Performance Scale; CPS), pain (Pain Assessment Checklist for Seniors with Limited Ability to Communicate; PACSLAC-D), neuropsychiatric symptoms (Neuropsychiatric Inventory-Nursing Home Version; NPI-NH) and comorbidities...
2016: Dementia and Geriatric Cognitive Disorders
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