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Current Opinion in Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/28731887/risk-of-anaphylaxis-in-complementary-and-alternative-medicine
#1
Natasha C Gunawardana
PURPOSE OF REVIEW: Complementary and alternative medicine (CAM) use is widespread across the world. Patients with asthma and allergy regularly use CAM therapies. Allergic and anaphylactic reactions to CAM have been reported. RECENT FINDINGS: Recent attempts to regulate and monitor adverse reaction to these therapies have given us further insight into potential causes of severe allergic reactions. Several culprits identified including Andrographis paniculata, Echinacea species, bee products, Ginkgo biloba and Ginseng are discussed here...
July 20, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28594644/comparing-the-evidence-in-allergic-rhinitis-guidelines
#2
Dana V Wallace, Mark S Dykewicz
PURPOSE OF REVIEW: The review compares and contrasts seven major United States and international allergic rhinitis guidelines from 2008 to 2017. RECENT FINDINGS: Despite many treatment options for allergic rhinitis, patients often report lack of therapeutic control and a reduced quality of life. Guidelines intended to improve allergic rhinitis care have been evolving into evidence based, systematic reviews, with less reliance on consensus of expert opinion characteristic of more traditional guidelines...
June 7, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28548971/allergic-contact-dermatitis-in-preservatives-current-standing-and-future-options
#3
Gustavo Deza, Ana M Giménez-Arnau
PURPOSE OF REVIEW: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation. RECENT FINDINGS: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control...
May 25, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28658067/seasonal-allergic-rhinitis-a-focused-systematic-review-and-practice-parameter-update
#4
Dana V Wallace, Mark S Dykewicz
PURPOSE OF REVIEW: The review compares and contrasts seven major United States and international allergic rhinitis guidelines from 2008 to 2017. RECENT FINDINGS: Despite many treatment options for allergic rhinitis, patients often report lack of therapeutic control and a reduced quality of life. Guidelines intended to improve allergic rhinitis care have been evolving into evidence based, systematic reviews, with less reliance on consensus of expert opinion characteristic of more traditional guidelines...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28622171/reactions-to-cytostatic-agents-in-children
#5
Josefina R Cernadas
PURPOSE OF REVIEW: The current review will focus on drug hypersensitivity reactions to chemotherapy specifically to those drugs most used in children. We know that potentially all chemotherapeutic agents can cause infusion reactions, generally defined as adverse drug reactions. Of these, some are Type A, defined as expected and described in the characteristics of the drug and others, and Type B, defined as unexpected reactions which cannot be explained by the known toxicity profile of the drug...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28622170/skin-allergy
#6
Torsten Zuberbier, Thomas Werfel
No abstract text is available yet for this article.
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28622169/molecular-aspects-of-allergens-in-atopic-dermatitis
#7
Raffaela Campana, Sheron Dzoro, Irene Mittermann, Elena Fedenko, Olga Elisyutina, Musa Khaitov, Alexander Karaulov, Rudolf Valenta
PURPOSE OF REVIEW: Molecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies. Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28598865/drug-allergy-hypersensitivity-in-adults-and-children
#8
Bernard Y-H Thong, Miguel Blanca
No abstract text is available yet for this article.
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28590311/aspirin-challenge-and-desensitization-how-when-and-why
#9
Gabriele Cortellini, Cristiano Caruso, Antonino Romano
PURPOSE OF REVIEW: To investigate the current approach to aspirin challenge (drug provocation) and/or desensitization in patients with histories of hypersensitivity reactions to it, particularly in those with cardiovascular diseases. RECENT FINDINGS: The literature indicates that patients with coronary artery disease (CAD), including those with an acute coronary syndrome, may safely undergo low-dose aspirin challenge and/or desensitization. Recently, flowcharts regarding challenge/desensitization procedures with aspirin in patients with CAD and histories of aspirin hypersensitivity reactions have become available...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28582322/atopic-dermatitis-phenotypes-and-the-need-for-personalized-medicine
#10
Beatriz Cabanillas, Ann-Christin Brehler, Natalija Novak
PURPOSE OF REVIEW: To describe recent developments in therapies which target the molecular mechanisms in atopic dermatitis. RECENT FINDINGS: Current advances in the understanding of the molecular basis of atopic dermatitis are leading to the stratification of different atopic dermatitis phenotypes. New therapies offer the option to target-specific molecules involved in the pathophysiology of atopic dermatitis. Current new therapies under investigation aim to modulate specific inflammatory pathways associated with distinctive atopic dermatitis phenotypes, which would potentially translate into the development of personalized, targeted-specific treatments of atopic dermatitis...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28570344/pharmacotherapy-of-mast-cell-disorders
#11
Theo Gülen, Cem Akin
PURPOSE OF REVIEW: Mast cell disorders (MCDs) comprise mastocytosis and disorders referred to as mast cell activation syndrome and are caused by abnormal accumulation and/or activation of mast cells in tissues. Clinical signs and symptoms are protean; therefore, finding suitable treatment options for individual patients entails a challenge for clinicians. The purpose of this manuscript is to review the literature on the available therapeutic interventions in patients with MCD. RECENT FINDINGS: Pharmacotherapy is mainly directed against the effects of mast cells and their mediators...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28537934/alternative-treatments-for-chronic-spontaneous-urticaria-beyond-the-guideline-algorithm
#12
Gino A Vena, Marcus Maurer, Nicoletta Cassano, Torsten Zuberbier
PURPOSE OF REVIEW: The international EAACI/GALEN/EDF/WAO guideline suggests a stepwise approach for the therapeutic management of chronic spontaneous urticaria (CSU), outlined in an algorithm. The aim of this article is to summarize and review the evidence available on alternative treatment options for CSU outside of this algorithm. RECENT FINDINGS: Although CSU is a common disease, there are a limited number of high-quality studies, and only antihistamines and omalizumab are licensed for its treatment...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28537933/hypersensitivity-reactions-to-gadolinium-based-contrast-agents
#13
Jie Shen Fok, William B Smith
PURPOSE OF REVIEW: Gadolinium-based contrast agents (GBCAs) have been utilized since the late 1980s to enhance the diagnostic value of MRI studies. They are known to have excellent safety profile and serious adverse reactions are uncommon despite widespread global use. However, immediate hypersensitivity reactions are well described in the literature, with urticaria the most common manifestation. Anaphylaxis can occur, though fatality is extremely rare. This review explores the incidence of GBCA-related hypersensitivity reactions and highlights potential risk factors...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28525399/allergen-immunotherapy-for-the-treatment-of-respiratory-allergies-in-the-elderly
#14
Gyu-Young Hur, Ji-Ho Lee, Hae-Sim Park
PURPOSE OF REVIEW: Respiratory allergies, including asthma and allergic rhinitis can also occur in the elderly. Allergen immunotherapy for allergic diseases is the only disease-modifying treatment for patients with allergies available thus far. Here, we review current evidence supporting the use of allergen immunotherapy in the elderly and discuss its efficacy and utility for the treatment of respiratory allergic diseases in this setting. RECENT FINDINGS: Subcutaneous and/or sublingual immunotherapy are effective therapeutic options in not only young but also older patients...
August 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28403019/food-labeling-issues-in-patients-with-severe-food-allergies-solving-a-hamlet-like-doubt
#15
Vincenzo Fierro, Francesco Di Girolamo, Valeria Marzano, Lamia Dahdah, Maurizio Mennini
PURPOSE OF REVIEW: We review the laws on labeling in the international community, the difficulties they pose to the food manufacturers to prepare the food labels and the methodologies to determine the concentration of potential allergens in foods. RECENT FINDINGS: European Food Safety Authority and International Life Sciences Institute Europe are evaluating strategies to identify the threshold level of allergen that can trigger a reaction in individuals. The most used techniques to detect the presence of protein in food are Enzyme-linked immunosorbent assay, polymerase chain reaction and real time polymerase chain reaction...
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28379866/editorial-outcome-measures
#16
R Maximiliano Gómez, Henry Milgrom
No abstract text is available yet for this article.
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28379865/severe-food-allergies-can-they-be-considered-rare-diseases
#17
Alessandro Fiocchi, Motohiro Ebisawa
No abstract text is available yet for this article.
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28375933/use-of-biologics-in-severe-food-allergies
#18
Alessandro Fiocchi, Valentina Pecora, Rocco L Valluzzi, Vincenzo Fierro, Maurizio Mennini
PURPOSE OF REVIEW: Severe cases of food allergy account for the majority of the burden in terms of risks, quality of life, and resource expenditure. The traditional approach to these forms has been strict avoidance. More recently, Oral ImmunoTherapy (OIT) has gained a role in their management. However, in severe food allergies OIT is often infeasible. RECENT FINDINGS: Case reports, observational, and prospective studies have recently proposed different approaches to severe food allergy...
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28375932/outstanding-animal-studies-in-allergy-ii-from-atopic-barrier-and-microbiome-to-allergen-specific-immunotherapy
#19
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal studies published within the past 18 months were assessed, focusing on innate and specific immunomodulation, providing knowledge of high translational relevance for human atopic and allergic diseases. RECENT FINDINGS: Allergic companion animals represent alternative models, but most studies were done in mice. Atopic dermatitis mouse models were refined by the utilization of cytokines like IL-23 and relevant skin allergens or enzymes. A novel IL-6 reporter mouse allows biomonitoring of inflammation...
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28362676/behavioral-interventions-to-improve-asthma-outcomes-a-systematic-review-of-recent-publications
#20
Giselle S Mosnaim, Esra Akkoyun, Joshua Eng, Madeleine U Shalowitz
PURPOSE OF REVIEW: Asthma outcomes are influenced by factors at multiple ecological levels: the individual and his/her family, home, medical care, and community. This systematic review describes recently published single-level and multilevel behavioral interventions to improve asthma outcomes. RECENT FINDINGS: Of the 23 total title/abstracts reviewed in the original systematic search of PubMed, Ovid, Scopus, PsychINFO, and CIHAHL reference review databases, six met inclusion criteria...
June 2017: Current Opinion in Allergy and Clinical Immunology
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