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Current Opinion in Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/29601356/current-opinion-in-allergy-and-clinical-immunology-a-change-in-leadership
#1
Stephanie Fairbairn
No abstract text is available yet for this article.
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601352/avenues-for-research-in-food-allergy-prevention-unheeded-ideas-from-the-epidemiology
#2
Alessandro Fiocchi, Motohiro Ebisawa
No abstract text is available yet for this article.
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601351/how-to-predict-and-improve-prognosis-of-food-allergy
#3
Lamia Dahdah, Valentina Pecora, Carla Riccardi, Vincenzo Fierro, Rocco Valluzzi, Maurizio Mennini
PURPOSE OF REVIEW: The prevalence of food allergy is increasing. More children are being diagnosed with food allergies, and it is taking longer to outgrow them, among those who develop tolerance. The aim of this review is to draw the profile of the persistent food allergic, so that prevention strategies can be developed and active treatment set up. RECENT FINDINGS: Many determinants are involved in food allergy prognosis: ethnicity and sex, type of food, innate immune system, eliciting dose, sensitization status and other biomarkers determination, gut microbiome composition, and the presence of comorbidities...
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29561357/how-to-manage-food-allergy-in-nursery-or-school
#4
Roxanne C Oriel, Julie Wang
PURPOSE OF REVIEW: The aim of this review is to describe effective management strategies in nursery or school based upon research findings. RECENT FINDINGS: The prevalence of food allergy and number of emergency department visits for food-related anaphylaxis are increasing in children and adolescents. As there is currently no cure, the most effective strategy to decrease allergic reactions is food allergen avoidance. However, allergic reactions are inevitable in both food allergic children as well as in first-time reactors...
March 20, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29561356/food-allergy-trends-at-the-crossing-among-socio-economics-history-and-geography
#5
Alessandro Fiocchi, Lamia Dahdah, Vincenzo Fierro, Maria C Artesani, Rocco Valluzzi
PURPOSE OF REVIEW: The epidemiology of food allergy did inspire theories on the reasons for the recent surge of the disease. We offer here a reasoned review on the relationships between the trajectories of human development and the trend of the food allergy epidemics. RECENT FINDINGS: The exponential trend of the frequency of food allergy paralleled the explosive acceleration of the human development over the last few decades. Dietary factors have been indicated as responsible for these trends and targeted for potential preventive strategies...
March 20, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29561355/nonspecific-immunomodulators-for-recurrent-respiratory-tract-infections-wheezing-and-asthma-in-children-a-systematic-review-of-mechanistic-and-clinical-evidence
#6
Susanna Esposito, Manuel E Soto-Martinez, Wojciech Feleszko, Marcus H Jones, Kun-Ling Shen, Urs B Schaad
PURPOSE OF REVIEW: To provide an overview of the mechanistic and clinical evidence for the use of nonspecific immunomodulators in paediatric respiratory tract infection (RTI) and wheezing/asthma prophylaxis. RECENT FINDINGS: Nonspecific immunomodulators have a long history of empirical use for the prevention of RTIs in vulnerable populations, such as children. The past decade has seen an increase in both the number and quality of studies providing mechanistic and clinical evidence for the prophylactic potential of nonspecific immunomodulators against both respiratory infections and wheezing/asthma in the paediatric population...
March 20, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29561354/endotypes-in-allergic-diseases
#7
Ioana Agache, Liliana Rogozea
PURPOSE OF REVIEW: The precision medicine concept is both appealing and challenging. We review here the recent findings in the endotype-driven approach for major allergic diseases. RECENT FINDINGS: Stratified medicine for different allergic diseases can identify patients who are more likely to benefit or experience an adverse reaction in response to a given therapy and anticipate their long-term outcome and vital risk. In addition, this approach potentially facilitates drug development and prevention strategies...
March 20, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629957/how-to-actively-treat-food-allergy
#8
Valentina Pecora, Maurizio Mennini, Veronica Calandrelli, Giampiero Patriarca, Rocco Valluzzi, Vincenzo Fierro
PURPOSE OF REVIEW: In the last years, food allergy treatment is moving away from food avoidance to interventional treatments. We review here the recent developments on immunotherapy with food allergens. RECENT FINDINGS: Oral immunotherapy remains the best studied form of food immunotherapy. In 2017, further evidence has been added to its efficacy. Its mechanisms of action are under scrutiny. To reduce its side effects, studies have been dedicated to the simultaneous use of biologics, in particular omalizumab...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629956/what-you-should-not-miss-from-the-systematic-reviews-and-meta-analyses-on-allergen-specific-immunotherapy-in-2017
#9
Désirée Larenas-Linnemann, Jorge A Luna-Pech
PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or efficacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). RECENT FINDINGS: We identified 4 systematic reviews and 10 meta-analyses...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629955/how-to-manage-food-dependent-exercise-induced-anaphylaxis-fdeia
#10
Tomoyuki Asaumi, Motohiro Ebisawa
PURPOSE OF REVIEW: In recent years, the number of reports on food-dependent exercise-induced anaphylaxis (FDEIA) has been increasing. This review aims to describe the standard management of FDEIA including provocation tests and identify the issues that remain unclear. RECENT FINDINGS: Provocation tests with aspirin for FDEIA enable us to confirm the definitive diagnosis and to make differential diagnosis. In some cases, FDEIA symptoms can be induced by aspirin and the causative food without exercise...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29608468/oral-food-challenge-using-different-target-doses-and-time-intervals-between-doses
#11
Noriyuki Yanagida, Sakura Sato, Ken-Ichi Nagakura, Tomoyuki Asaumi, Motohiro Ebisawa
PURPOSE OF REVIEW: The oral food challenge (OFC) is a specific and vital tool used in clinical practice to identify the level of tolerance a person exhibits toward certain foods while diagnosing food-related allergies. OFC methods differ among countries. The aim of this review is to evaluate different target doses and determine the time interval between doses used for OFC. RECENT FINDINGS: We analyzed recent articles on target doses and time between doses, and noted that some papers reported low target doses and less time between doses...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29608467/how-to-cope-with-food-allergy-symptoms
#12
Antoine Deschildre, Stéphanie Lejeune
PURPOSE OF REVIEW: Food allergy symptoms may involve a wide variety of organs (skin, gastrointestinal tract, and eyes) and systems (respiratory, circulatory, and neurological). They are often associated. Their severity ranges from mild to potentially life-threatening reactions and the presentation from acute to chronic. RECENT FINDINGS: Food allergies have been the focus of multiple studies, position papers, and guidelines in recent years. They have defined an approach in classifying symptoms as mild to anaphylactic, distinguishing objective from subjective symptoms, and describing their heterogeneity, specific phenotypes or syndromes (e...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601357/application-of-precision-medicine-to-the-treatment-of-anaphylaxis
#13
Marina Labella, Marlene Garcia-Neuer, Mariana Castells
PURPOSE OF REVIEW: Recognize the presentation of anaphylaxis for prompt management and treatment and to provide tools for the diagnosis of the underlying cause(s) and set up a long-term treatment to prevent recurrence of anaphylaxis. RECENT FINDINGS: The recent description of phenotypes provides new insight and understanding into the mechanisms and causes of anaphylaxis through a better understanding of endotypes and biomarkers for broad clinical use. SUMMARY: Anaphylaxis is the most severe hypersensitivity reaction and can lead to death...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601355/how-to-prevent-food-allergy-during-infancy-what-has-changed-since-2013
#14
William J Lavery, Amal Assa'ad
PURPOSE OF REVIEW: The purpose of this review is to summarize recent studies and emerging consensus guidelines regarding food allergy prevention in infants of the past 5 years. RECENT FINDINGS: Prior to 2013, the general consensus regarding prevention of food allergy in infants was to recommend delayed introduction or complete avoidance of commonly allergenic foods, such as milk, egg and peanut. However, in the past 5 years, several landmark studies have been conducted, particularly with peanut...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601354/phenotypes-endotypes-driven-treatment-in-asthma
#15
Fulvio Braido, Angelica Tiotiu, Krzysztof Kowal, Stefan Mihaicuta, Plamena Novakova, Ipek Kivilcim Oguzulgen
PURPOSE OF REVIEW: Target therapy is the necessary step towards personalized medicine. The definition of asthma phenotypes and underlying mechanisms (endotypes) represent a key point in the development of new asthma treatments. Big data analysis, biomarker research and the availability of monoclonal antibodies, targeting specific cytokines is leading to the rapid evolution of knowledge. In this review, we sought to outline many of the recent advances in the field. RECENT FINDINGS: Several attempts have been made to identify asthma phenotypes, sometimes with contrasting results...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29601353/how-to-diagnose-food-allergy
#16
Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa
PURPOSE OF REVIEW: To assess the recent studies that focus on specific immunoglobulin E (sIgE) testing and basophil activation test (BAT) for diagnosing IgE-mediated food allergies. RECENT FINDINGS: The sIgE to allergen extract or component can predict reactivity to food. The cutoff value based on the positive predictive value (PPV) of sIgE can be considered whenever deciding whether oral food challenge (OFC) is required to diagnose hen's egg, cow's milk, wheat, peanut, and cashew nut allergy...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29561358/precision-medicine-in-the-area-of-work-related-asthma
#17
Susan M Tarlo, Piero Maestrelli
No abstract text is available yet for this article.
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29493555/assessing-the-impact-of-air-pollution-on-childhood-asthma-morbidity-how-when-and-what-to-do
#18
Allison J Burbank, David B Peden
PURPOSE OF REVIEW: Exposure to air pollutants is linked with poor asthma control in children and represents a potentially modifiable risk factor for impaired lung function, rescue medication use, and increased asthma-related healthcare utilization. Identification of the most relevant pollutants to asthma as well as susceptibility factors and strategies to reduce exposure are needed to improve child health. RECENT FINDINGS: The current available literature supports the association between pollutants and negative asthma outcomes...
April 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29461276/health-surveillance-for-occupational-asthma
#19
David Fishwick, Steve Forman
PURPOSE OF REVIEW: The outcome for workers with occupational asthma is improved for those with an earlier diagnosis. Health surveillance at work is in principle designed to identify such cases, so that the risks to the individual worker, and coworkers, can be reduced. There is recent evidence to suggest that the uptake and quality of such surveillance could be improved. This review has assessed current approaches to health surveillance for occupational asthma. RECENT FINDINGS: The article covers a review of the utility of questionnaires, lung function testing, immunological investigations, and other tests, including exhaled nitric oxide, sputum eosinophilia, and exhaled breath condensate specifically in the context of workplace-based health surveillance...
April 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29406361/precision-medicine-in-the-treatment-of-primary-immunodeficiency-diseases
#20
Jennifer W Leiding, Mark Ballow
PURPOSE OF THE REVIEW: Since the 1990s with the advances in molecular biology, a number of genetic defects have been described. The International Union of Immunological Sciences has recently updated the classification of genetic defects associated with primary immune deficiencies that now number 354. With the ever-expanding list of new monogenic disorders and a better understanding of the immunobiology and function of these defective genes, new therapies have emerged particularly aimed at the autoimmune and inflammatory conditions that plague these patients...
April 2018: Current Opinion in Allergy and Clinical Immunology
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