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Critical Reviews in Oncology/hematology

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https://www.readbyqxmd.com/read/29731124/corrigendum-to-endoscopic-resection-with-adjuvant-chemo-radiotherapy-for-superficial-esophageal-squamous-cell-carcinoma-a-critical-review-crit-rev-oncol-hematol-124-april-2018-61-65
#1
Tsz Yeung Kam, Melpomeni Kountouri, Arnaud Roth, Jean-Louis Frossard, Olivier Huber, Stefan Mönig, Thomas Zilli
No abstract text is available yet for this article.
May 3, 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958636/targeting-the-cellular-schizophrenia-likely-employment-of-the-antipsychotic-agent-pimozide-in-treatment-of-refractory-cancers-and-glioblastoma
#2
REVIEW
Ilhan Elmaci, Meric A Altinoz
Pimozide is currently being used in clinic as a neuroleptic and exerts versatile biological actions. Pimozide is a cationic amphiphilic drug (CAD); CADs block the synthesis of neutral lipids, impair cholesterol homeostasis of cancer cells and increase accumulation of diacylglycerol-3-phosphate. Pimozide exerts tumoricidal activity which was first shown for melanoma and neuroblastoma via proposed anti- dopaminergic effects. Recently, pancreas cancers are shown to elevate dopamine receptor-2 synthesis, which is blocked by pimozide leading growth inhibition...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958635/tafro-syndrome-critical-review-for-clinicians-and-pathologists
#3
REVIEW
Paydas Semra
TAFRO is an acrostic and includes thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R) and organomegaly (O) (Takai et al., 2013). TAFRO syndrome has been described firstly by Takai in Japanese patients. However TAFRO cases have been reported from US, Europe and other countries (Takai et al., 2010; Iwaki et al., 2016; Abdo et al., 2014). Three major and at least one minor criteria and exclusion of infectious, rheumatologic and neoplastic diseases are required for the diagnosis of TAFRO. In fact TAFRO must be thought in clinically undiagnosed and unsolved problemmatic cases...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958634/radiation-therapy-in-renal-cell-carcinoma
#4
REVIEW
Francesca De Felice, Vincenzo Tombolini
Renal cell carcinoma (RCC) is classically regarded as extremely resistant to classical fractionated radiation therapy (RT). Nowadays, there is convincing data supporting RCC radiosensitivity to high fraction doses, which may represent an ideal issue for new treatment strategies in primary and oligometastatic RCC disease. This review discusses the role of RT in RCC and its potential therapeutic scenario focusing on the most interesting clinical trials.
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958633/molecular-targets-of-celastrol-in-cancer-recent-trends-and-advancements
#5
REVIEW
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Tapan Mukherjee, Anupam Bishayee
Despite the advancement in the well-equipped and sophisticated laboratories and facilities, cancer remains to be a major cause of death worldwide. Consequently, further investigation of novel strategies need to be evolved. Since the last few decades, the utilization of phytochemicals is emerging against several human cancers, including lung, breast, colon carcinoma, lymphoma, and other hematological malignancies. Terpenoids are a category of therapeutically active phytochemicals that have been utilized against cancer, cardiovascular and neurodegenerative disorders...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958632/a-revisited-concept-tumors-wounds-that-do-not-heal
#6
REVIEW
Domenico Ribatti, Roberto Tamma
In 1986, Harold F. Dvorak, Professor of Pathology at Harvard Medical School Boston, published an essay in the New England Journal of Medicine entitled "Tumors: Wounds that do not heal" pointed out that similarities exist between tumor stroma generation and wound healing. Cancers share many features in common with tissue regeneration, including immune response, cell proliferation, cell migration, tissue remodeling, and cell death. In this review article, we analyze the importance and the limits of this concept, which confirm the close relationship between two apparently different biological processes...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958631/perioperative-chemotherapy-for-urothelial-carcinoma-of-the-upper-urinary-tract-a-systematic-review-and-meta-analysis
#7
REVIEW
Richard W Gregg, Francisco E Vera-Badillo, Christopher M Booth, Aamer Mahmud, Michael Brundage, Michael J Leveridge, Timothy P Hanna
INTRODUCTION: Upper tract urothelial carcinomas are rare malignancies with differences in anatomy and biology requiring therapeutic strategies that differ from bladder cancer. The role of perioperative systemic therapy in this disease remains uncertain with limited data to support its use. A systematic review of the literature and meta-analysis was therefore undertaken to provide more information and guide clinical practice. METHODS: A literature search was performed using Embase and Medline databases with additional searches performed manually using terms associated with upper tract urothelial malignancies...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958630/glutathione-system-in-animal-model-of-solid-tumors-from-regulation-to-therapeutic-target
#8
REVIEW
Claudia Rita Corso, Alexandra Acco
Glutathione (GSH) is one of the most important defenses against oxidative stress through the fine-tuned regulation of redox homeostasis. Glutathione is also involved in many metabolic processes and is important for the regulation of cell survival, proliferation, and death. Furthermore, GSH and the enzymes that are involved in its biosynthesis, catabolism, and detoxification (e.g., disulfide-oxidized glutathione, glutathione S-transferase, glutathione peroxidase, glutathione reductase, and γ-glutamyltranspetidase) play an important role in several diseases, including cancer...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958629/therapeutic-vaccines-and-immune-checkpoints-inhibition-options-for-gynecological-cancers
#9
REVIEW
Chiara Di Tucci, Michele Carlo Schiavi, Pierangelo Faiano, Ottavia D'Oria, Giovanni Prata, Valentina Sciuga, Andrea Giannini, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Treatments for gynecological cancer include surgery, chemotherapy, and radiation. However, overall survival is not improved, and novel approaches are needed. Immunotherapy has been proven efficacious in various types of cancers and multiple approaches have been recently developed. Since numerous gynecological cancers are associated to human papilloma virus (HPV) infections, therapeutic vaccines, targeting HPV epitopes, have been developed. The advancing understanding of the immune system, regulatory pathways and tumor microenvironment have produced a major interest in immune checkpoint blockade, Indeed, immune checkpoint molecules are important clinical targets in a wide variety of tumors, including gynecological...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958628/therapeutic-perspectives-for-brain-metastases-in-non-oncogene-addicted-non-small-cell-lung-cancer-nsclc-towards-a-less-dismal-future
#10
REVIEW
Stefano Frega, Laura Bonanno, Valentina Guarneri, Pierfranco Conte, Giulia Pasello
Risk of brain metastases (BM) affects a remarkable number of non-small cell lung cancer (NSCLC) patients, impacting on their quality of life (QoL) and prognosis. While tyrosine-kinase inhibitors (TKIs) showed interesting intracranial control rates in oncogene-addicted NSCLC, BM still represent an unmet need for the counterpart without driver gene mutations. For these patients, new treatment options include anti-angiogenic drugs and immune-checkpoint inhibitors, possibly combined with standard chemotherapy, even though the benefit on BM has not been clearly defined...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958627/antiangiogenic-therapy-markers-of-response-normalization-and-resistance
#11
REVIEW
Karima El Alaoui-Lasmaili, Béatrice Faivre
Currently in cancer treatment, one premise is to use antiangiogenic therapies in association with chemotherapy or radiotherapy to augment their efficacy by benefiting from the vascular "normalization" induced by antiangiogenic therapy. This concept defines the time during which the tumor blood vessels adopt normal-like morphology and functionality, i.e. the blood vessels become more mature, the perfusion augments and hypoxia decreases. To date, there is such a diversity of treatment protocols where the type of antiangiogenic to adopt, its dose and duration of administration are different, that knowing when and how to treat is problematic...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958626/incidence-and-clinical-parameters-associated-with-eribulin-mesylate-induced-peripheral-neuropathy
#12
REVIEW
Bin Zhao, Hong Zhao, Jiaxin Zhao
Eribulin mesylate is a microtubule-targeting agent that has been approved for the treatment of breast cancer and liposarcoma. Due to its novel mechanism of action, eribulin therapy induces a distinct profile of adverse events, including peripheral neuropathy. However, the incidence and risk of eribulin-related neurotoxicities are unclear. Here, we conducted a systematic search of PubMed and Embase from their inception to October 2017. Eligible studies included trials in which eribulin was intravenously administered at a standard dose of 1...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29958625/manipulating-macrophage-polarization-and-function-using-classical-hdac-inhibitors-implications-for-autoimmunity-and-inflammation
#13
REVIEW
Asadollah Mohammadi, Atefeh Sharifi, Reza Pourpaknia, Saeed Mohammadian, Amirhossein Sahebkar
Macrophages are important player in defense against invading pathogens and their dysfunction is linked to most of inflammatory and autoimmune diseases. Inflammation is a normal and physiological response of the immune system against harmful stimuli such as infection and injury. However, when allowed to continue unchecked, under certain conditions it turns into autoimmune or inflammatory diseases, neurodegeneration, and carcinogenesis. Currently, several safe and effective anti-inflammatory drugs are available with many more drugs in the development pipeline, among which are histone deacetylase inhibitors...
August 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891116/cancer-cachexia-diagnosis-assessment-and-treatment
#14
REVIEW
Mohammadamin Sadeghi, Mahsa Keshavarz-Fathi, Vickie Baracos, Jann Arends, Maryam Mahmoudi, Nima Rezaei
Cancer cachexia is a multi-factorial syndrome, which negatively affects quality of life, responsiveness to chemotherapy, and survival in advanced cancer patients. Our understanding of cachexia has grown greatly in recent years and the roles of many tumor-derived and host-derived compounds have been elucidated as mediators of cancer cachexia. However, cancer cachexia remains an unmet medical need and attempts towards a standard treatment guideline have been unsuccessful. This review covers the diagnosis, assessment, and treatment of cancer cachexia; the elements impeding the formulation of a standard management guideline; and future directions of research for the improvement and standardization of current treatment procedures...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891115/a-network-meta-analysis-of-the-treatments-for-esophageal-squamous-cell-carcinoma-in-terms-of-survival
#15
REVIEW
Amin Doosti-Irani, Kourosh Holakouie-Naieni, Abbas Rahimi-Foroushani, Mohammad Ali Mansournia, Peiman Haddad
We aimed to compare treatments for patients with esophageal squamous cell carcinoma (SCC) in terms of survival. Medline, Web of Science, Scopus, the Cochrane Library and Embase were searched. Randomized controlled trials (RCT) that had compared esophageal SCC treatments were included. The hazard ratio (HR) with 95% credible interval (CrI) was used to summarize the effect measures in the Bayesian network meta-analysis. Out of 23,256 references, 43 RCTs with 34 treatments were included. Carboplatin and paclitaxel plus radiotherapy plus surgery (carbo-pacli + RT + S) compared with surgery alone decreased risk of death (HR = 0...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891114/the-unfolded-protein-response-as-a-target-for-anticancer-therapeutics
#16
REVIEW
Mengxiong Wang, Mary E Law, Ronald K Castellano, Brian K Law
The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells, responsible for protein synthesis, folding, sorting, and transportation. ER stress is initiated when the unfolded or misfolded protein load exceeds the capacity of the ER to properly fold protein. Tumor microenvironmental conditions, such as nutrient deprivation, hypoxia, and oxidative stress perturb protein folding and trigger chronic ER stress. Cancer cells can tolerate mild ER stress, however, persistent and severe ER stress kills cancer cells by inducing their autophagy, apoptosis, necroptosis, or immunogenic cell death...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891113/paraoxonase-1-activity-in-patients-with-cancer-a-systematic-review-and-meta-analysis
#17
REVIEW
M Arenas, E Rodríguez, A Sahebkar, S Sabater, D Rizo, O Pallisé, M Hernández, F Riu, J Camps, J Joven
PURPOSE: Paraoxonase-1 (PON1) is a lipolactonase implicated in the elimination of carcinogenic free radicals and in the scavenging mechanisms to maintain oxidative balance. The objective of the present systematic review and meta-analysis was to evaluate possible alterations in serum PON1 activity in patients with cancer. METHODS: A systematic search of the observational studies in humans published in the last 15 years was performed through Medline databases following the PRISMA and STARLITE statements...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891112/molecular-analysis-in-liquid-biopsies-for-diagnostics-of-primary-central-nervous-system-lymphoma-review-of-literature-and-future-opportunities
#18
REVIEW
Laura S Hiemcke-Jiwa, Roos J Leguit, Tom J Snijders, N Mehdi Jiwa, Jonas J W Kuiper, Roel A de Weger, Monique C Minnema, Manon M H Huibers
Primary central nervous system lymphoma (PCNSL) is an aggressive lymphoma with a poor prognosis, for which accurate and timely diagnosis is of utmost importance. Unfortunately, diagnosis of PCNSL can be challenging and a brain biopsy (gold standard for diagnosis) is an invasive procedure with the risk of major complications. Thus, there is an urgent need for an alternative strategy to diagnose and monitor these lymphomas. Currently, liquid biopsies from cerebrospinal fluid (CSF) are used for cytomorphologic and flow cytometric analysis...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891111/5-lipoxygenase-its-involvement-in-gastrointestinal-malignancies
#19
REVIEW
Neha Merchant, Lakkakula V K S Bhaskar, Saimila Momin, Peela Sujatha, Aramati B M Reddy, Ganji Purnachandra Nagaraju
Lipoxygenases (LOXs) are dioxygenases that catalyze the peroxidation of linoleic acid (LA) or arachidonic acid (AA), in the presence of molecular oxygen. The existence of inflammatory component in the tumor microenvironment intimately links the LOXs to gastrointestinal (GI) cancer progression. Amongst the six-different human LOX-isoforms, 5-LOX is the most vital enzyme for leukotriene (LT) biosynthesis, which is the main inflammation intermediaries. As recent investigations have shown the association of 5-LOX with tumor metastasis, there has also been significant progress in discovering the function of 5-LOX pathway in GI cancer...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29891110/antinuclear-antibodies-and-cancer-a-literature-review
#20
REVIEW
Alexandru Vlagea, Sandra Falagan, Gerardo Gutiérrez-Gutiérrez, Juan Moreno-Rubio, María Merino, Francisco Zambrana, Enrique Casado, María Sereno
Antinuclear antibodies (ANAs) are a spectrum of autoantibodies targeted to various nuclear and cytoplasmic components of the cells. They are very useful as serological markers for different autoimmune disease, like systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), scleroderma, polymyositis, or mixed connective tissue disease. In these years, an increasing attention has been focussed in the relationship between tumours and autoimmunity. Different authors have demonstrated that ANAs are presented, not only in autoimmune diseases, also in serum of patients with different types of cancers...
July 2018: Critical Reviews in Oncology/hematology
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