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Critical Reviews in Oncology/hematology

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https://www.readbyqxmd.com/read/29242024/continuity-and-diversity
#1
EDITORIAL
Matti Aapro
No abstract text is available yet for this article.
December 7, 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198853/effects-of-exercise-on-cancer-patients-suffering-chemotherapy-induced-peripheral-neuropathy-undergoing-treatment-a-systematic-review
#2
REVIEW
Federica Duregon, Barbara Vendramin, Valentina Bullo, Stefano Gobbo, Cugusi Lucia, Andrea Di Blasio, Daniel Neunhaeuserer, Marco Zaccaria, Marco Bergamin, Andrea Ermolao
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurological and clinically relevant side effect of many commonly used chemotherapeutic agents. Moreover, little effort has been done to investigate the potentially beneficial effects of specific exercises to counteract the CIPN symptoms. OBJECTIVE: This document aims to summarize and analyze systematically the current body of evidence about the effects of specific exercise protocols on CIPN symptoms, balance control, physical function and quality of life in patients with CIPN...
November 7, 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279102/a-question-of-class-treatment-options-for-patients-with-relapsed-and-or-refractory-multiple-myeloma
#3
REVIEW
Gordon Cook, Sonja Zweegman, María-Victoria Mateos, Florence Suzan, Philippe Moreau
Multiple classes of agent with distinct mechanisms of action are now available for the treatment of patients with relapsed and/or refractory multiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies. Additionally, several different drugs may be available within each agent class, each with their own specific efficacy and safety profile. This expansion of the treatment landscape has dramatically improved outcomes for patients. However, as the treatment options for RRMM become more complex, choosing the class of agent or combination of agents to use in the relapsed setting becomes increasingly challenging...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279101/the-relationship-between-body-mass-index-and-short-term-postoperative-outcomes-in-patients-undergoing-potentially-curative-surgery-for-colorectal-cancer-a-systematic-review-and-meta-analysis
#4
REVIEW
Arwa S Almasaudi, Stephen T McSorley, Christine A Edwards, Donald C McMillan
BACKGROUND: The prevalence of obesity has increased worldwide over the last few decades, and is a well-recognized risk factor for colorectal cancer. Surgical site infection is the most frequent complication following surgery for colorectal cancer, and the main cause of postoperative morbidity. The aim of the present systematic review and meta-analysis was to examine the relationship between increasing BMI and postoperative surgical site infection following surgery for colorectal cancer...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279100/long-term-toxicity-of-the-treatment-for-germ-cell-cancer-a-review
#5
REVIEW
P Maroto, G Anguera, C Martin
Testicular germ-cell cancer (GCC) is a curable disease. Stage I patients are mostly cured by surgery alone. For those with good prognosis advanced disease, radiotherapy in some patients with stage II Seminoma and chemotherapy for all other patients, are responsible for 95% of long-term survivors. Unfortunately, despite this high level of curability, overall survival has been reported lower for those patients receiving either radiotherapy or chemotherapy versus patients treated by surgery alone. Long-term survivors face a higher incidence of second neoplasms, and a higher risk of cardiovascular disease and metabolic syndrome than expected...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279099/a-review-of-the-literature-on-the-relationships-between-genetic-polymorphisms-and-chemotherapy-induced-nausea-and-vomiting
#6
REVIEW
Komal P Singh, Anand A Dhruva, Elena Flowers, Kord M Kober, Christine Miaskowski
Despite current advances in antiemetic treatments, between 30% to and 60% of oncology patients experience chemotherapy-induced nausea (CIN) and 13% to 33% report chemotherapy-induced vomiting (CIV). Inter-individual differences are observed in the occurrence and severity of chemotherapy-induced nausea and vomiting (CINV). This review summarizes and critiques studies on associations between occurrence and severity of CINV and polymorphisms in serotonin receptor, drug metabolism, and drug transport pathway genes...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279098/systematic-review-and-survival-meta-analysis-of-real-world-evidence-on-first-line-pazopanib-for-metastatic-renal-cell-carcinoma
#7
REVIEW
Miguel A Climent, José Muñoz-Langa, Laura Basterretxea-Badiola, Carmen Santander-Lobera
A systematic review was conducted to identify real world studies reporting outcomes after first-line pazopanib in patients with metastatic renal cell carcinoma. Studies had to be observational and report survival data in terms of progression-free survival and overall survival in order to conduct meta-analysis techniques. These real-world data were compared to those obtained in the phase II and III randomized controlled trials of pazopanib. Real world evidence showed that the clinical and safety outcomes were consistent with those observed in the clinical trials despite the inclusion of unselected patients with a wide spectrum of prognostic features and comorbidities...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279097/epigenetic-regulation-of-the-hedgehog-and-wnt-pathways-in-cancer
#8
REVIEW
Leon J Wils, Maarten F Bijlsma
The Hedgehog (Hh) and wingless-Int1 (Wnt) pathways are important for tissue patterning in the developing embryo. In adult tissue, both pathways are typically dormant but are activated under certain conditions such as tissue damage. Aberrant activation of these pathways by mutations in key pathway regulators contributes to the genesis and progression of several cancer types. In addition, the impact of epigenetic regulation of the Hh and Wnt pathways on cancer is becoming increasingly clear. In this review, current knowledge on the epigenetic control of Hh and Wnt and the impact on tumor formation will be discussed...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279096/e-cadherin-its-dysregulation-in-carcinogenesis-and-clinical-implications
#9
REVIEW
Sonia How Ming Wong, Chee Mun Fang, Lay-Hong Chuah, Chee Onn Leong, Siew Ching Ngai
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT), E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29279095/the-predictive-value-of-primary-tumor-location-in-patients-with-metastatic-colorectal-cancer-a-systematic-review
#10
REVIEW
Nele Boeckx, Katleen Janssens, Guy Van Camp, Marika Rasschaert, Konstantinos Papadimitriou, Marc Peeters, Ken Op de Beeck
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. It has been reported that left- and right-sided CRC harbor varying disease characteristics, which leads to a difference in prognosis and response to therapy. Recently, there have been retrospective studies about tumor location in metastatic CRC (mCRC) and its potential to predict the effect of anti-vascular endothelial growth factor and anti-epidermal growth factor receptor (anti-EGFR) therapies. In this review, we provide a comprehensive overview of the latest trials studying the predictive value of primary tumor location in mCRC and discuss biomarkers that might be associated with the differences in treatment response...
January 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198343/incidence-of-skin-toxicity-in-squamous-cell-carcinoma-of-the-head-and-neck-treated-with-radiotherapy-and-cetuximab-a-systematic-review
#11
REVIEW
Pierluigi Bonomo, Mauro Loi, Isacco Desideri, Emanuela Olmetto, Camilla Delli Paoli, Francesca Terziani, Daniela Greto, Monica Mangoni, Silvia Scoccianti, Gabriele Simontacchi, Giulio Francolini, Icro Meattini, Saverio Caini, Lorenzo Livi
PURPOSE: Radiotherapy plus cetuximab is an effective combination therapy for locally advanced head and neck squamous cell carcinoma. The aim of our study was to determine the frequency of skin toxicity in patients receiving the combined treatment. RESULTS: Forty-eight studies were included in our analysis, for a total of 2152 patients. The mean rates of G3/G4 radiation dermatitis and acneiform rash were 32.5% (SD: 20.4; 95% CI: 28.5-36.5) and 13.4% (SD: 11.5; 95% CI: 11...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198342/management-of-salivary-gland-malignant-tumor-the-policlinico-umberto-i-sapienza-university-of-rome-head-and-neck-unit-clinical-recommendations
#12
REVIEW
Francesca De Felice, Marco de Vincentiis, Valentino Valentini, Daniela Musio, Silvia Mezi, Luigi Lo Mele, Marco Della Monaca, Vittorio D'Aguanno, Valentina Terenzi, Martina Di Brino, Edoardo Brauner, Nadia Bulzonetti, Gianluca Tenore, Giulia Pomati, Andrea Cassoni, Mario Tombolini, Andrea Battisti, Antonio Greco, Giorgio Pompa, Antonio Minni, Umberto Romeo, Enrico Cortesi, Antonella Polimeni, Vincenzo Tombolini
Salivary gland malignant tumor (SGMT) is a malignant disease requiring multidisciplinary approach. The rare incidence and the consequent lack of robust evidence-based medicine has called for a comprehensive update to draw recommendations for clinical practice. This paper is a summary of the XXX Head and Neck Unit guidelines regarding the management of SGMT. Recommendations include the indications for exclusive and adjuvant therapy, as well as metastatic management, for both major and minor SGMT.
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198341/concomitant-use-of-corticosteroids-and-immune-checkpoint-inhibitors-in-patients-with-hematologic-or-solid-neoplasms-a-systematic-review
#13
REVIEW
A Garant, C Guilbault, T Ekmekjian, Z Greenwald, P Murgoi, T Vuong
PURPOSE: Clinical trials studying immune checkpoint inhibitors exclude patients on corticosteroids, due to the hypothesis that corticosteroids may antagonize immunotherapy. We performed a systematic review of the literature looking at the clinical outcomes of cancer patients treated with immune checkpoint inhibitors and concomitant corticosteroids. METHODS: The following databases were searched for relevant studies: MEDLINE, Embase Classic+Embase, BIOSIS Previews, the Cochrane Database of Systematic Reviews, the CENTRAL Registry of Controlled Trials, Web of Science and Scopus...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198340/emerging-roles-for-long-noncoding-rnas-in-b-cell-development-and-malignancy
#14
REVIEW
M Winkle, J L Kluiver, A Diepstra, A van den Berg
Long noncoding (lnc)RNAs have emerged as essential mediators of cellular biology, differentiation and malignant transformation. LncRNAs have a broad range of possible functions at the transcriptional, posttranscriptional and protein level and their aberrant expression significantly contributes to the hallmarks of cancer cell biology. In addition, their high tissue- and cell-type specificity makes lncRNAs especially interesting as biomarkers, prognostic factors or specific therapeutic targets. Here, we review current knowledge on lncRNA expression changes during normal B-cell development, indicating essential functions in the differentiation process...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198339/patterns-and-drivers-of-health-care-use-in-long-term-childhood-cancer-survivors-a-systematic-review
#15
REVIEW
J van Breeschoten, R De Abreu Lourenco, C Signorelli, M Haas, R J Cohn, C E Wakefield, J E Fardell
BACKGROUND: Childhood cancer survival is increasing. But cancer and treatment late-effects can lead to ongoing health care use. We summarised the literature on the patterns and drivers of health care use among childhood cancer survivors. METHOD: Pubmed, Embase and Medline were searched for studies reporting health care use in childhood cancer survivors. RESULTS: We included 22 studies, covering 88787 experiences of health care use. The proportion of survivors using follow-up care, physician visits, specialist visits, hospitalisations, dental care and screening services varied (36...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198338/ponatinib-in-chronic-myeloid-leukemia-cml-consensus-on-patient-treatment-and-management-from-a-european-expert-panel
#16
REVIEW
Martin C Müller, Francisco Cervantes, Henrik Hjorth-Hansen, Jeroen J W M Janssen, Dragana Milojkovic, Delphine Rea, Gianantonio Rosti
Five tyrosine kinase inhibitors (TKIs) are currently approved in the European Union for treatment of chronic myeloid leukemia (CML) and all have considerable overlap in their indications. While disease-specific factors such as CML phase, mutational status, and line of treatment are key to TKI selection, other important features must be considered, such as patient-specific comorbidities and TKI safety profiles. Ponatinib, the TKI most recently approved, has demonstrated efficacy in patients with refractory CML, but is associated with an increased risk of arterial hypertension, sometimes severe, and serious arterial occlusive and venous thromboembolic events...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198337/ovarian-sex-cord-stromal-tumours-and-small-cell-tumours-pathological-genetic-and-management-aspects
#17
REVIEW
Stergios Boussios, Michele Moschetta, George Zarkavelis, Alexandra Papadaki, Aristides Kefas, Konstantina Tatsi
Non-epithelial ovarian cancers (NEOC) constitute a group of uncommon malignancies and their treatment is still a challenging task. Collectively, these tumours account for about 10% of all ovarian cancers and occur in all age groups from childhood to old-age. They include malignancies of germ cell origin, sex cord-stromal cell origin, and a variety of extremely rare ovarian cancers, such as small-cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. It is imperative that these rare tumours are managed with accurate diagnosis, staging, and treatment, to optimise the outcome...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198336/fertility-management-for-malignant-ovarian-germ-cell-tumors-patients
#18
REVIEW
Chiara Di Tucci, Assunta Casorelli, Elisa Morrocchi, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
Malignant Germ Cell Tumors have primarily affecting adolescents and young adults. In advanced disease, greater than 70% of patients can be cured with standard chemotherapy regimens and fertility-sparing surgery appears to be safe with excellent survival after long-term follow-up. Due to their rarity, follow up and fertility management is largely based on trials of epithelial ovarian cancer or on few small studies. We report a review of the literature studies about the assessment, the monitoring and the treatment of fertility for Malignant Germ Cell Tumors as pratical guidelines for management of fertility in these patients...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198335/micrornas-in-glioblastoma-pathogenesis-and-therapy-a-comprehensive-review
#19
REVIEW
Bhavesh K Ahir, Howard Ozer, Herbert H Engelhard, Sajani S Lakka
Glioblastoma (GBM), also known as grade IV astrocytoma, is the most aggressive primary intracranial tumor of the adult brain. MicroRNAs (miRNAs), a class of small non-coding RNA species, have critical functions across various biological processes. A great deal of progress has been made recently in dissecting miRNA pathways associated with the pathogenesis of GBM. miRNA expression signatures called gene signatures also characterize and contribute to the phenotypic diversity of GBM subclasses through their ability to regulate developmental growth and differentiation...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198334/mind-and-body-practices-for-fatigue-reduction-in-patients-with-cancer-and-hematopoietic-stem-cell-transplant-recipients-a-systematic-review-and-meta-analysis
#20
REVIEW
Nathan Duong, Hailey Davis, Paula D Robinson, Sapna Oberoi, Danielle Cataudella, S Nicole Culos-Reed, Faith Gibson, Miriam Götte, Pamela Hinds, Sanne L Nijhof, Deborah Tomlinson, Patrick van der Torre, Elena Ladas, Sandra Cabral, L Lee Dupuis, Lillian Sung
PURPOSE: To determine whether non-physical activity mind and body practices reduce the severity of fatigue in patients with cancer or hematopoietic stem cell transplant (HSCT) recipients compared to control interventions. METHODS: We included randomized trials which compared non-physical activity mind and body practices compared with control interventions for the management of fatigue in cancer and HSCT patients. RESULTS: Among 55 trials (4975 patients), interventions were acupuncture or acupressure (n=12), mindfulness (n=11), relaxation techniques (n=10), massage (n=6), energy therapy (n=5), energizing yogic breathing (n=3) and others (n=8)...
December 2017: Critical Reviews in Oncology/hematology
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