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Contact Dermatitis

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https://www.readbyqxmd.com/read/29230841/photoaggravated-allergic-contact-dermatitis-and-transient-photosensitivity-caused-by-methylisothiazolinone
#1
Olivier Aerts, An Goossens, Marie-Claude Marguery, Michel Castelain, Lucile Boursault, Françoise Giordano-Labadie, Julien Lambert, Brigitte Milpied
BACKGROUND: Photoaggravated allergic contact dermatitis caused by methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) and MI has been reported. OBJECTIVES: To describe the clinical characteristics and results of (photo)patch tests and photo-tests of 10 patients in Belgium and France suffering from photoaggravated contact dermatitis caused by MI. PATIENTS AND METHODS: Five men and five women, with a median age of 49.5 years, were investigated between January 2012 and February 2017 because of suspected photoaggravated contact dermatitis...
December 12, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29214642/allergic-contact-dermatitis-caused-by-topical-herbal-remedies-importance-of-patch-testing-with-the-patients-own-products
#2
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Natural ingredients have variable compositions, so their allergenic potencies may differ. OBJECTIVES: To retrospectively analyse subjects reacting to herbal remedies over the past 27 years, with the aim of (i) evaluating demographic characteristics and lesion locations, (ii) describing the frequencies of positive patch test reactions, (iii) identifing sensitization sources, and (iv) studying concomitant sensitivity. PATIENTS AND METHODS: In total, 15980 patients were patch tested between 1990 and 2016 with the European baseline series and/or other series, product(s) used, and, whenever possible, the respective ingredients...
December 7, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29210087/methotrexate-use-in-allergic-contact-dermatitis-a-retrospective-study
#3
Ashaki Patel, Erin Burns, Nicole M Burkemper
BACKGROUND: Methotrexate, a folate antimetabolite, is used to treat atopic dermatitis and psoriasis. Although methotrexate's therapeutic efficacy has been noted in the literature, there are few data on the efficacy of methotrexate treatment for allergic contact dermatitis. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in treating allergic contact dermatitis at a single institution, and also to assess methotrexate efficacy in patients with chronic, unavoidable allergen exposure...
December 6, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29205369/regulatory-b-cells-induced-by-ultraviolet-b-through-toll-like-receptor-4-signalling-contribute-to-the-suppression-of-contact-hypersensitivity-responses-in-mice
#4
Xiaoming Liu, Haiyan Huang, Hongbin Gao, Xia Wu, Wei Zhang, Bo Yu, Xia Dou
BACKGROUND: Ultraviolet (UV) B irradiation is known to suppress contact hypersensitivity (CHS) responses in mouse models by suppressing immune responses. However, the cellular mechanisms responsible for UVB-induced systemic suppression remain unclear. Regulatory B cells have been reported to play an inhibitory role during CHS. It is presently unknown whether regulatory B cells contribute to the effect of UVB phototherapy. OBJECTIVE: To investigate the inductive effect of UVB on regulatory B cells and the underlying mechanisms by using a CHS mouse model...
December 5, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29194657/a-proposal-to-create-an-extension-to-the-european-baseline-series
#5
Mark Wilkinson, Rosella Gallo, An Goossens, Jeanne D Johansen, Thomas Rustemeyer, Javier Sánchez-Pérez, Marie L Schuttelaar, Wolfgang Uter
BACKGROUND: The current European baseline series consists of 30 allergens, and was last updated in 2015. OBJECTIVES: To use data from the European Surveillance System on Contact Allergies (ESSCA) to propose an extension to the European baseline series in response to changes in environmental exposures. METHODS: Data from departmental and national extensions to the baseline series, together with some temporary additions from departments contributing to the ESSCA, were collated during 2013-2014...
December 1, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29193145/polyethylene-glycol-as-marker-for-nitrofurazone-allergy-20%C3%A2-years-of-experience-from-turkey
#6
Esen Özkaya, Sıla Kılıç
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. They are potential contact sensitizers, including low molecular weight PEGs in nitrofurazone preparations that are still widely used in Turkey. OBJECTIVES: To investigate the prevalence of allergic contact dermatitis caused by PEG and PG in a relatively large group of patients in Turkey. METHODS: In this retrospective, cross-sectional, single-centre study, 836 patients patch tested with PEG and PG between 1996 and 2015 were reviewed...
November 28, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29178341/persistence-of-contact-allergy-a-retrospective-analysis
#7
Daan Dittmar, Robert F Ofenloch, Marie L A Schuttelaar
BACKGROUND: Studies have shown that not all positive patch test reactions are reproducible upon retesting, that is, persistent. Non-persistent reactions might represent initial false-positive reactions, meaning that patients might unnecessarily avoid allergens. OBJECTIVES: To investigate the occurrence of both persistent and non-persistent patch test reactions, to explore possible explanations, and to investigate whether allergen-specific differences exist. METHODS: A retrospective analysis was performed on patients who were patch tested at least twice between 1 January 1995 and 31 October 2016, with at least one positive patch test reaction to an allergen that had been retested...
November 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29178264/assessing-the-validity-of-self-reported-history-of-rash-caused-by-metal-or-jewellery
#8
Lauren N Ko, Daniela Kroshinsky, Peter C Schalock
BACKGROUND: The use of metal-containing bio-devices is becoming increasingly common. Self-reported history of dermatitis with metal exposure is not established as being predictive for metal allergy. OBJECTIVES: To assess the validity of two screening questions addressing metal allergy. METHODS: At Massachusetts General Hospital Contact Dermatitis Clinic, 2132 consecutive patients were asked either 'Do you get rashes when jewellery touches your skin' (Q1; N = 1816) or 'Do you get rashes when metal touches your skin?' (Q2; N = 316) before being patch tested...
November 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29168189/imaging-mass-spectrometry-for-novel-insights-into-contact-allergy%C3%A2-%C3%A2-a-proof-of-concept-study-on-nickel
#9
Per Malmberg, Thomas Guttenberg, Marica B Ericson, Lina Hagvall
BACKGROUND: In spite of extensive regulation to limit exposure, nickel remains the main cause of contact allergy in the general population. More detailed knowledge on the skin uptake of haptens is required. So far, no method exists for the visualization of clinically relevant haptens and their distribution in the skin. OBJECTIVES: To show, in terms of a proof of concept, that imaging mass spectrometry [time of flight secondary ion mass spectrometry (ToF-SIMS)] can be applied for investigation of the penetration and distribution of nickel in human skin...
November 23, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29152821/skin-care-products-can-aggravate-epidermal-function-studies-in-a-murine-model-suggest-a-pathogenic-role-in-sensitive-skin
#10
Zhengxiao Li, Lizhi Hu, Peter M Elias, Mao-Qiang Man
BACKGROUND: Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin. OBJECTIVE: To assess whether vehicles, as well as certain branded skin care products, can alter epidermal function following topical applications to normal mouse skin...
November 20, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29148058/classification-of-consumer-products-under-the-eu-clp-regulation-what-to-consider-when-caring-for-contact-dermatitis-patients
#11
REVIEW
Peter Elsner
Possibly hazardous chemical substances and mixtures need to be clearly and correctly classified and labelled, in order for their hazards to be properly identified and communicated. As dermatologists may encounter cases of harm to patients induced by chemicals, such as chemical burns, and irritant and allergic contact dermatitis, it is essential for them to be aware of the EU CLP Regulation and its potential pitfalls. Manufacturers are required by CLP to classify their products according to the rules given in the CLP Regulation...
November 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29148057/clinical-patterns-of-compositae-dermatitis-in-danish-monosensitized-patients
#12
Evy Paulsen, Klaus E Andersen
BACKGROUND: Compositae dermatitis was originally described as airborne contact dermatitis. More recent studies have reported a wider clinical spectrum, but often in polysensitized patients. OBJECTIVE: To evaluate the clinical features of patients sensitized to Compositae only. PATIENTS/METHODS: Consecutive Compositae-sensitive eczema patients, tested between 1990 and 2015, who, at the patch testing session diagnosing their Compositae allergy, were found to be sensitized only to the plant family, were included...
November 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29114901/allergic-contact-dermatitis-caused-by-calcipotriol
#13
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported. OBJECTIVES: To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. METHODS: Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines...
November 8, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29076574/uk-trends-of-allergic-occupational-skin-disease-attributed-to-fragrances-1996-2015
#14
Rachel L Montgomery, Raymond Agius, Stephen M Wilkinson, Melanie Carder
BACKGROUND: Fragrances are well known to cause allergic contact dermatitis (ACD). Occupationally related cases occur, with certain groups being at higher risk. OBJECTIVE: To investigate the incidence of occupationally related cases of cutaneous fragrance allergy and to evaluate trends. METHOD: Data on incident cases of occupational ACD caused by fragrances between 1996 and 2015 (inclusive) reported to the EPIDERM surveillance scheme were analysed...
October 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29076572/occupational-hand-eczema-and-or-contact-urticaria-factors-associated-with-change-of-profession-or-not-remaining-in-the-workforce
#15
Tanja K Carøe, Niels E Ebbehøj, Jens P Bonde, Tove Agner
BACKGROUND: Occupational hand eczema and/or contact urticaria may have social consequences such as change of profession or not remaining in the workforce. OBJECTIVES: To identify factors associated with job change in a cohort of participants with recognised occupational hand eczema/contact urticaria METHODS: A registry-based study including 2703 employees with recognised occupational hand eczema/contact urticaria in Denmark in 2010/2011. Four to five years later the participants received a follow-up questionnaire, comprising questions on current job situation (response rate 58...
October 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29044554/contact-dermatitis-caused-by-a-new-rubber-compound-detected-in-canvas-shoes
#16
Eva Hulstaert, Ola Bergendorff, Christina Persson, An Goossens, Liesbeth Gilissen, Malin Engfeldt, Magnus Bruze, Marie L Schuttelaar, Joost M Meijer, Hilde Lapeere
BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes. OBJECTIVES: To identify the culprit allergen in the shoes. METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series...
October 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28961320/self-testing-for-contact-allergy-to-hair-dyes%C3%A2-%C3%A2-a-5-year-follow-up-multicentre-study
#17
Ulrik F Friis, An Goosens, Ana Maria Giménez-Arnau, Carola Lidén, Elena Giménez-Arnau, Ian R White, Jose H Alfonso, Wolfgang Uter, Jeanne D Johansen
BACKGROUND: In 2011, a multicentre study was conducted in order to determine how hair dye manufacturers instructed consumers to perform a self-test prior to dyeing their hair, in order to identify individuals who are likely to react upon subsequent hair dyeing. A number of concerns were raised concerning the variability in instructions between products and producers, and the safety and validity of this tool. OBJECTIVES: To perform a 5-year follow-up study in order to determine whether manufacturers still recommend a self-test, and if so, whether the procedures have been changed...
September 29, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28960334/are-the-spanish-baseline-series-markers-sufficient-to-detect-contact-allergy-to-corticosteroids-in-spain-a-geidac-prospective-study
#18
Pedro Mercader-García, María A Pastor-Nieto, Ignacio García-Doval, Ana Giménez-Arnau, Ricardo González-Pérez, Virginia Fernández-Redondo, Ester Serra-Baldrich, Susana Cordoba-Guijarro, María E Gatica-Ortega, Juan F Silvestre-Salvador
BACKGROUND: Corticosteroids are among the most commonly used topical drugs. Contact allergy to these exists, but can be easily missed. Corticosteroid screening markers have been included in the baseline series with the aim of detecting most of the sensitized patients. OBJECTIVES: To assess the prevalence of contact allergy to topical corticosteroids in Spain and examine the usefulness of corticosteroid markers to detect contact allergy to corticosteroids. METHODS: In total, 3699 patients referred to 20 dermatology departments across Spain for patch testing with the baseline series, including budesonide and tixocortol pivalate, were also tested with six supplementary corticosteroids (methylprednisolone aceponate, mometasone furoate, prednicarbate, clobetasol propionate, betamethasone 17-valerate, and betamethasone 17,21-dipropionate)...
September 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28940507/contact-dermatitis-caused-by-tulips-identification-of-contact-sensitizers-in-tulip-workers-of-kashmir-valley-in-north-india
#19
Iffat Hassan, Farhan Rasool, Saniya Akhtar, Afifa Kamili, Parvaiz Rather, Raihana Kanth, Yasmeen Bhat, Shagufta Rather, Syed Mubashir, Atiya Yaseen, Safia Bashir
BACKGROUND: Tulip, belonging to the genus Tulipa and family Liliaceae, is a spring-blooming perennial that grows from bulbs. Owing to manual handling, contact dermatitis can occur in professionals at any stage of the growth cycle of the tulip plant. OBJECTIVES: To determine the clinical pattern of contact dermatitis resulting from tulip plant cultivation, and to assess contact allergy in workers coming into contact with this plant. METHODS: One hundred and sixty-four tulip workers were screened, and 48 patients with suspected contact dermatitis were patch tested with 39 allergens, including haptens from the Indian baseline series, a plant series, and extracts from different parts of the tulip plant...
September 21, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28940487/when-should-the-diagnosis-contact-urticaria-be-used
#20
Kristiina Aalto-Korte
In the dermatological literature, the term 'contact urticaria syndrome' is often used with patients presenting no symptoms of contact urticaria, but symptoms of adjacent mucous membranes evolving to a systemic allergic reaction. Contact urticaria refers to a wheal and flare reaction following external contact with a causative substance. Its use should be restricted to skin: a skin reaction after direct skin contact.
September 21, 2017: Contact Dermatitis
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