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Contact Dermatitis

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https://www.readbyqxmd.com/read/28730661/patch-testing-in-non-immediate-cutaneous-adverse-drug-reactions-value-of-extemporaneous-patch-tests
#1
Haudrey Assier, Laurence Valeyrie-Allanore, Gwendeline Gener, Muriel Verlinde Carvalh, Olivier Chosidow, Pierre Wolkenstein
BACKGROUND: Patch testing following a standardized protocol is reliable for identifying the culprit drug in cutaneous adverse drug reactions (CADRs). However, these patch tests (PTs) require pharmaceutical material and staff, which are not always easily available. OBJECTIVES: To evaluate an extemporaneous PT method in CADRs. METHODS: We retrospectively analysed data for all patients referred to our department between March 2009 and June 2013 for patch testing after a non-immediate CADR...
July 21, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28730624/prevalence-of-nickel-allergy-in-europe-following-the-eu-nickel-directive%C3%A2-%C3%A2-a-review
#2
REVIEW
Malin G Ahlström, Jacob P Thyssen, Torkil Menné, Jeanne D Johansen
Nickel contact allergy remains a problem in EU countries, despite the EU Nickel Directive. To study the prevalence of nickel allergy in EU countries following the implementation of the EU Nickel Directive, we performed a systematic search in PubMed for studies that examined the prevalence of nickel allergy in EU countries published during 2005-2016. We identified 46 studies: 10 in the general population and 36 in patch tested dermatitis patients. A significantly lower prevalence of nickel allergy after than before the implementation of the EU Nickel Directive was found in women aged 18-35 years (11...
July 21, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28695639/variation-in-aluminium-patch-test-reactivity-over-time
#3
Ingrid Siemund, Martin Mowitz, Erik Zimerson, Magnus Bruze, Monica Hindsén
BACKGROUND: Contact allergy to aluminium has been reported more frequently in recent years. It has been pointed out that positive patch test reactions to aluminium may not be reproducible on retesting. OBJECTIVES: To investigate possible variations in patch test reactivity to aluminium over time. METHODS: Twenty-one adults, who had previously reacted positively to aluminium, were patch tested with equimolar dilution series in pet. of aluminium chloride hexahydrate and aluminium lactate, four times over a period of 8 months...
July 11, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28685882/simultaneous-patch-testing-with-fragrance-mix-i-fragrance-mix-ii-and-their-ingredients-in-southern-sweden-between-2009-and-2015
#4
Martin Mowitz, Cecilia Svedman, Erik Zimerson, Marléne Isaksson, Ann Pontén, Magnus Bruze
BACKGROUND: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. OBJECTIVES: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. MATERIALS AND METHODS: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. RESULTS: Of the patients, 6...
July 7, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28677261/immunological-chemical-and-clinical-aspects-of-exposure-to-mixtures-of-contact-allergens
#5
REVIEW
Charlotte M Bonefeld, Carsten Geisler, Elena Gimenéz-Arnau, Jean-Pierre Lepoittevin, Wolfgang Uter, Jeanne D Johansen
Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. In this article, we provide a general introduction to immune responses to contact allergens, and discuss the literature concerning immune responses to mixtures of allergens. According to the existing evidence, increased responses are induced following sensitization with combinations of allergens as compared with single allergens...
July 5, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28675523/allergic-contact-dermatitis-caused-by-a-new-temporary-blue-black-tattoo-dye%C3%A2-%C3%A2-sensitization-to-genipin-from-jagua-genipa-americana-l-fruit-extract
#6
Andreas J Bircher, Rita Sigg, Kathrin Scherer Hofmeier, Urs Schlegel, Urs Hauri
BACKGROUND: Temporary tattoos made with an extract of the jagua fruit (Genipa americana L.) are becoming increasingly popular. It is claimed that it is 'dermatologically tested' and does not contain p-phenylenediamine. Extracts of jagua and gardenia fruits have been used by indigenous people in South America, as well as in traditional Chinese medicine, for centuries. Genipin is currently used for its cross-linking effect in the manufacture of polysaccharides, and is being investigated for its anti-inflammatory and other properties...
July 4, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28675503/a-population-based-study-of-self-reported-skin-exposures-and-symptoms-in-relation-to-contact-allergy-in-adolescents
#7
Maria Lagrelius, Carl-Fredrik Wahlgren, Mihály Matura, Anna Bergström, Inger Kull, Carola Lidén
BACKGROUND: Knowledge about the relations between skin exposures, skin symptoms and contact allergy in adolescents is limited. OBJECTIVES: To explore self-reported skin exposures and skin symptoms in girls and boys, and to assess the associations between exposures, symptoms and contact allergy at age 16 years. PARTICIPANTS AND METHODS: In all, 3115 adolescents from the population-based BAMSE birth cohort answered a questionnaire at age 16 concerning various skin exposures and related skin symptoms...
July 4, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28675438/biological-monitoring-of-dermal-and-air-exposure-to-cobalt-at-a-swedish-hard-metal-production-plant-does-dermal-exposure-contribute-to-uptake
#8
Maria Klasson, Magnus Lindberg, Ing-Liss Bryngelsson, Helena Arvidsson, Carin Pettersson, Bente Husby, Håkan Westberg
BACKGROUND: Occupational exposure to cobalt is well established in hard metal manufacture. Cobalt is known to cause contact allergy, asthma, hard metal lung disease, and lung cancer. The relationship between skin exposure and uptake determined in blood has not been extensively investigated. OBJECTIVE: To examine whether skin and inhalable air exposure to cobalt contributes to uptake, determined as cobalt in blood, in a hard metal manufacturing factory. METHODS: The amount of cobalt on the skin found with an acid wash technique, the air concentrations of inhalable cobalt and cobalt blood concentrations were determined and correlated in exposed workers...
July 4, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28656588/allergic-contact-dermatitis-caused-by-meth-acrylates-in-long-lasting-nail-polish%C3%A2-%C3%A2-are-we-facing-a-new-epidemic-in-the-beauty-industry
#9
Maria-Elena Gatica-Ortega, Maria-Antonia Pastor-Nieto, Pedro Mercader-García, Juan-Francisco Silvestre-Salvador
BACKGROUND: Allergic contact dermatitis (ACD) caused by (meth)acrylates has been described both in occupational and in non-occupational settings. OBJECTIVES: To evaluate the clinical patterns, the most frequent allergens and the prognosis in patients sensitized to (meth)acrylates in long-lasting nail polish. METHODS: The files of patients with ACD caused by (meth)acrylates in long-lasting nail polish diagnosed between January 2013 and June 2016 in four dermatology departments in Spain were reviewed...
June 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28555927/sensitization-and-cross-reactivity-patterns-of-contact-allergy-to-diisocyanates-and-corresponding-amines-investigation-of-diphenylmethane-4-4-diisocyanate-diphenylmethane-4-4-diamine-dicyclohexylmethane-4-4-diisocyanate-and-dicylohexylmethane-4-4-diamine
#10
Haneen Hamada, Magnus Bruze, Erik Zimerson, Marléne Isaksson, Malin Engfeldt
BACKGROUND: Isocyanates are used in polyurethane production. Dermal exposure to isocyanates can induce contact allergy. The most common isocyanate is diphenylmethane diisocyanate used for industrial purposes. The isomer diphenylmethane-4,4'-diisocyanate (4,4'-MDI) is used in patch testing. Diphenylmethane-4,4'-diamine (4,4'-MDA) is its corresponding amine. Concurrent reactions to 4,4'-MDI and 4,4'-MDA have been reported, as have concurrent reactions to 4,4'-MDI and dicyclohexylmethane-4,4'-diisocyanate (4,4'-DMDI)...
May 29, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28555887/in-vitro-detection-of-chemical-allergens-an-optimized-assay-using-mouse-bone-marrow-derived-dendritic-cells
#11
Fabrice Battais, Cécile Huppert, Isabelle Langonné, Samuel Muller, Isabelle Sponne
BACKGROUND: Identification of the allergenic potency of chemicals is a key step in the safety assessment process. Predictive assays that require no or few animals are needed. OBJECTIVES: To develop an alternative in vitro mouse bone marrow-derived dendritic cell (BMDC) assay to determine the allergenic potential of chemicals. METHODS: BMDCs were exposed to well-known allergens and to non-allergenic chemicals. Surface marker expression and cytokine release of BMDCs were analysed after treatment...
May 29, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28543097/contact-dermatitis-as-an-adverse-reaction-to-some-topically-used-european-herbal-medicinal-products-part-4-solidago-virgaurea-vitis-vinifera
#12
REVIEW
Paola L Minciullo, Gioacchino Calapai, Marco Miroddi, Carmen Mannucci, Ioanna Chinou, Sebastiano Gangemi, Richard J Schmidt
This review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the European Medicines Agency has completed an evaluation up to the end of November 2013 and for which a Community herbal monograph - now (since 2014) called a 'European Union herbal monograph' - has been produced. The present part 4 addresses species from Solidago virgaurea L. to Vitis vinifera L.
May 23, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28524256/quantification-of-l-carvone-in-toothpastes-available-on-the-swedish-market
#13
Liv Kroona, Gunnar Warfvinge, Marléne Isaksson, Camilla Ahlgren, Jakob Dahlin, Östen Sörensen, Magnus Bruze
BACKGROUND: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. OBJECTIVES: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market...
May 19, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28511284/non-mix-fragrances-are-top-sensitizers-in-consecutive-dermatitis-patients%C3%A2-%C3%A2-a-cross-sectional-study-of-the-26-eu-labelled-fragrance-allergens
#14
Niels H Bennike, Claus Zachariae, Jeanne D Johansen
BACKGROUND: For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene (Lim-OOH)] and oxidized linalool [hydroperoxides of linalool (Lin-OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients. OBJECTIVES: To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II...
May 16, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28504363/allergic-contact-dermatitis-caused-by-meth-acrylates-in-nail-cosmetic-products-in-users-and-nail-technicians%C3%A2-%C3%A2-a-5-year-study
#15
Inês Raposo, Inês Lobo, Cristina Amaro, Maria de Lurdes Lobo, Helena Melo, Joana Parente, Teresa Pereira, Joana Rocha, Ana P Cunha, Armando Baptista, Pedro Serrano, Teresa Correia, Ana R Travassos, Margarida Dias, Fátima Pereira, Margarida Gonçalo
BACKGROUND: The increasing use of long-lasting nail aesthetic products has led to a growing number of cases of allergic contact dermatitis (ACD) caused by (meth)acrylates in recent years. OBJECTIVES: To provide information on ACD caused by (meth)acrylates related to nail cosmetic products. METHODS: We retrospectively reviewed files of patients with ACD caused by (meth)acrylates related to nail cosmetic products, who were patch tested between January 2011 and December 2015 in 13 departments of dermatology in Portugal...
May 15, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28497472/current-knowledge-on-biomarkers-for-contact-sensitization-and-allergic-contact-dermatitis
#16
REVIEW
Sjors A Koppes, Kristiane A Engebretsen, Tove Agner, Irena Angelova-Fischer, Teresa Berents, Johanna Brandner, Richard Brans, Maja-Lisa Clausen, Edith Hummler, Ivone Jakasa, Ružica Jurakić-Tončic, Swen M John, Denis Khnykin, Sonja Molin, Jan O Holm, Sari Suomela, Hermann-Josef Thierse, Sanja Kezic, Stefan F Martin, Jacob P Thyssen
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis...
May 12, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28481015/guideline-for-translation-and-national-validation-of-the-quality-of-life-in-hand-eczema-questionnaire-qolheq
#17
Jart A F Oosterhaven, Marie L A Schuttelaar, Christian Apfelbacher, Thomas L Diepgen, Robert F Ofenloch
There is a need for well-developed and validated questionnaires to measure patient reported outcomes. The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is such a validated instrument measuring disease-specific health-related quality of life in hand eczema patients. A re-validation of measurement properties is required before an instrument is used in a new population. With the objective of arriving at a guideline for translation and national validation of the QOLHEQ, we have developed the design of a reference study on how to adequately assess measurement properties of the QOLHEQ based on interdisciplinary discussions and current standards...
May 8, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28449354/prevalence-of-and-work-related-risk-factors-for-hand-eczema-in-a-norwegian-general-population-the-hunt-study
#18
Hilde K Vindenes, Cecilie Svanes, Stein H L Lygre, Bjørg-Eli Hollund, Arnulf Langhammer, Randi J Bertelsen
BACKGROUND: Chemical exposures at work and at home may cause hand eczema. However, this has been scarcely described for Norway. OBJECTIVES: To investigate the prevalence of, and occupational risk factors for, hand eczema in Norway. METHODS: Among 50 805 respondents (aged ≥20 years) to the third Nord-Trøndelag Health Study (HUNT3), 5757 persons reported ever having hand eczema, and 4206 answered a hand eczema questionnaire. RESULTS: The lifetime prevalences of hand eczema were 8...
April 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28449346/airborne-allergic-contact-dermatitis-caused-by-isothiazolinones-in-water-based-paints-a-retrospective-study-of-44-cases
#19
Emmanuelle Amsler, Olivier Aerts, Nadia Raison-Peyron, Michèle Debons, Brigitte Milpied, Françoise Giordano-Labadie, Julie Waton, Marie C Ferrier-Le Bouëdec, Isabelle Lartigau, Catherine Pecquet, Haudrey Assier, Martine Avenel-Audran, Claire Bernier, Florence Castelain, Evelyne Collet, Marie-Noëlle Crépy, Nathalie Genillier, Pascal Girardin, Pauline Pralong, Florence Tetart, Dominique Vital-Durand, Angele Soria, Annick Barbaud
BACKGROUND: Airborne allergic contact dermatitis caused by paints containing isothiazolinones has been recognized as a health hazard. OBJECTIVES: To collect epidemiological, clinical and patch test data on airborne allergic contact dermatitis caused by isothiazolinone-containing paints in France and Belgium. METHODS: A descriptive, retrospective study was initiated by the Dermatology and Allergy Group of the French Society of Dermatology, including methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI)- and/or MI-sensitized patients who developed airborne allergic contact dermatitis following exposure to isothiazolinone-containing paint...
April 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28449188/development-validation-and-testing-of-a-skin-sampling-method-for-assessment-of-metal-exposure
#20
Behnaz Erfani, Klara Midander, Carola Lidén, Anneli Julander
BACKGROUND: Nickel, cobalt and chromium are frequent skin sensitizers. Skin exposure results in eczema in sensitized individuals, the risk being related to the skin dose. OBJECTIVES: To develop a self-sampling method for quantification of skin exposure to metals, to validate the method, and to assess its feasibility. METHODS: Defined metal doses (0.01-5 µg) were applied to the fingers of 5 participants. Skin areas (2 cm(2) ) were sampled with 1% HNO3 , either as 0...
April 27, 2017: Contact Dermatitis
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