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Contact Dermatitis

Verónica Moner, Estibalitz Fernández, Alfonso Del Pozo, Gelen Rodríguez, Mercedes Cócera, Alfonso de la Maza, Olga López
BACKGROUND: Many skin diseases are associated with either increases or decreases in lamellar body secretion, or dysfunctional lamellar bodies. Consequently, diseased skin is characterized by reduced barrier function and altered lipid composition and organization. Human skin is commonly evaluated in vivo with non-invasive biophysical techniques. The dynamic functions of the skin are evaluated with repeat measurements such as the sorption-desorption test (SDT). OBJECTIVES: The aim of this study was to evaluate in vivo skin hydration-dehydration kinetics after treatment with a lipid system that mimics the morphology, structure and composition of lamellar bodies in both healthy and irritated human skin...
March 16, 2017: Contact Dermatitis
Daan Dittmar, Marie Louise Schuttelaar
During the sensitization phase of allergic contact dermatitis, the proinflammatory cytokine tumour necrosis factor (TNF) plays an important role by promoting epidermal Langerhans cell migration to draining lymph nodes. It also plays a role during the elicitation phase. The TNF gene (TNF) is located within the major histocompatibility complex region. Many single-nucleotide variants exist in the promoter region of TNF, and these may either increase or decrease mRNA transcription and therefore lead to higher or lower levels of TNF...
March 16, 2017: Contact Dermatitis
Sjors A Koppes, Suzana Ljubojević Hadžavdić, Ivone Jakasa, Nika Franceschi, Christoph Riethmüller, Ružica Jurakić Tončic, Branka Marinovic, Nidhin Raj, Anthony V Rawlings, Rainer Voegeli, Majella E Lane, Marek Haftek, Monique H W Frings-Dresen, Thomas Rustemeyer, Sanja Kezic
BACKGROUND: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography. OBJECTIVE: To explore this phenomenon in allergic contact dermatitis. METHODS: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine...
March 14, 2017: Contact Dermatitis
Marc Schindewolf, Andreas Recke, Detlef Zillikens, Edelgard Lindhoff-Last, Ralf J Ludwig
BACKGROUND: Heparins are widely used for the prophylaxis/treatment of thromboembolic events. As adverse effects, heparin-induced skin lesions occur frequently (in 7.5-39% of patients). Skin lesions may be the only clinical manifestation of life-threatening immune-mediated heparin-induced thrombocytopenia, but are commonly caused by a delayed-type hypersensitivity response [heparin-induced delayed-type hypersensitivity (HIHS)]. Risk factors have not been prospectively identified. OBJECTIVES: To identify possible risk factors for heparin-induced skin lesions from three independent clinical trials in a combined analysis...
March 14, 2017: Contact Dermatitis
Heinrich Dickel, Johannes Geier, Burkhard Kreft, Wolfgang Pfützner, Oliver Kuss
BACKGROUND: The standardized protocol for performing the strip patch test has proven to be valid, but evidence on its reliability is still missing. OBJECTIVE: To estimate the parallel-test reliability of the strip patch test as compared with the conventional patch test. METHODS: In this multicentre, prospective, randomized, investigator-blinded reliability study, 132 subjects were enrolled. Simultaneous duplicate strip and conventional patch tests were performed with the Finn Chambers® on Scanpor® tape test system and the patch test preparations nickel sulfate 5% pet...
March 7, 2017: Contact Dermatitis
Annice Heratizadeh, Johannes Geier, Sonja Molin, Thomas Werfel
BACKGROUND: Textile dyes, rubber, elements or textile resins carry the risk of inducing allergic contact sensitization. OBJECTIVES: To assess clinical data and patch test results for dermatitis patients with suspected textile allergy. METHODS: A retrospective analysis of Information Network of Departments of Dermatology data of the years 2007-2014 of patients patch tested because of suspected textile allergy was performed. RESULTS: Patients of the study group (n = 3207) suffered more frequently from leg, trunk and generalized dermatitis than patients of the control group (n = 95210)...
February 24, 2017: Contact Dermatitis
Evy Paulsen, Mette G Hyldgaard, Klaus E Andersen, Flemming Andersen, Lars P Christensen
BACKGROUND: The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin. OBJECTIVES: To assess the sensitizing potential of sesquiterpene lactones from cushion bush. PATIENTS/MATERIALS/METHODS: Eleven Compositae-sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush...
February 14, 2017: Contact Dermatitis
Cornelia Erfurt-Berge, Johannes Geier, Vera Mahler
BACKGROUND: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization. OBJECTIVES: To identify the current spectrum of contact allergens in these patients. PATIENTS AND METHODS: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510)...
February 14, 2017: Contact Dermatitis
Sascha Ständer, Eva Oppel, Peter Thomas, Burkhard Summer
BACKGROUND: The patch test is considered to be the gold standard for diagnosing nickel (Ni) allergy. The lymphocyte transformation test (LTT) can also be used to detect Ni sensitization. However, little is known about the correlation between patch test and LTT reactions to Ni. OBJECTIVE: To establish and validate an LTT for Ni sensitization by comparison with patch test reaction and history. METHODS: Fifty individuals without self-reported 'Ni allergy' (controls) and 50 patients with self-reported suspicion of Ni allergy were included...
February 7, 2017: Contact Dermatitis
Morten M Nielsen, Jonas D Schmidt, Jan P Christensen, Carsten Geisler, Jeanne D Johansen, Charlotte M Bonefeld
BACKGROUND: Contact allergy is characterized by local skin inflammation that, in some cases, can result in systemic immune activation. OBJECTIVES: To investigate whether IVIS SpectrumCT analyses can be used to detect the immune response induced by contact allergens. METHODS: Mice were repeatedly exposed to vehicle or allergens on the ears. The local and systemic responses were analysed at different times with the ProSense 750 FAST probe in IVIS SpectrumCT measurements...
January 25, 2017: Contact Dermatitis
David Bregnbak, Jacob P Thyssen, Morten S Jellesen, Claus Zachariae, Jeanne D Johansen
BACKGROUND: Chromium coatings on metal alloys can be decorative, and prevent corrosion and metal ion release. We recently showed that handling of a chromium-containing disc resulted in chromium deposition on the skin. OBJECTIVES: To examine patch test reactivity to chromium-coated discs. METHODS: We included 15 patients: 10 chromium-allergic patients, and 5 patients without chromium allergy. All were patch tested with potassium dichromate, cobalt chloride, nickel sulfate, and nine different metallic discs...
January 25, 2017: Contact Dermatitis
Anne Bregnhøj, Mette Sommerlund
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
André Pinho, Luís Santiago, Margarida Gonçalo
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
Peter S Friedmann, Ciara Haddadeen, Chester Lai, Eugene Healy
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
Karolina Dumycz, Katarzyna Osinka, Wojciech Feleszko
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
Nicola Milanesi, Massimo Gola, Stefano Francalanci
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
Werner Adler, Olaf Gefeller, Wolfgang Uter
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
Leonardo Bianchi, Katharina Hansel, Elettra Antonelli, Veronica Bellini, Luca Stingeni
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
Sophie Colomb, Jean L Bourrain, Nathalie Bonardel, Anca Chiriac, Pascal Demoly
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
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