journal
MENU ▼
Read by QxMD icon Read
search

Clinical Transplantation

journal
https://www.readbyqxmd.com/read/29055147/cognitive-function-among-long-term-survivors-of-heart-transplantation
#1
Britta S Bürker, Einar Gude, Lars Gullestad, Ingelin Grov, Anne Relbo Authen, Arne K Andreassen, Odd E Havik, Mary Amanda Dew, Arnt E Fiane, Ira R Haraldsen, Ulrik F Malt, Stein Andersson
BACKGROUND: Cognitive impairment is documented early after heart transplantation (HTx), but we lack data on cognitive function beyond the fourth year posttransplant. Against the background of good long-term survival, this knowledge is necessary to improve clinical care throughout the entire posttransplant period. METHODS: We assessed cognitive function with a neuropsychological test battery in a sample of HTx recipients ≥16 years posttransplant. To improve clinical utility, we also applied adapted consensus criteria for Mild Cognitive Impairment (MCI)...
October 21, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29052906/evaluation-of-adherence-and-tolerability-of-prolonged-release-tacrolimus-advagraf-%C3%A2-in-kidney-transplant-patients-in-germany-a-multicenter-non-interventional-study
#2
Lukas J Lehner, Petra Reinke, Jan Hörstrup, Thomas Rath, Barbara Suwelack, Bernhard K Krämer, Klemens Budde, Bernhard Banas
This study assessed adherence to prolonged-release tacrolimus (PR-T)-based immunosuppression during routine maintenance of renal transplant recipients in Germany. Patients had received PR-T for ≥1 month at inclusion. Data were collected during four visits (V): baseline (V1), 6 (V2), 12 (V3) and 18 (V4) months. Composite primary endpoint: non-adherence at V4, defined as self-reported non-adherence on the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS©), investigator-rated non-adherence, and/or V4 tacrolimus trough level outside a pre-defined range...
October 20, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29044759/liver-transplant-length-of-stay-los-index-a-novel-predictive-score-for-hospital-length-of-stay-following-liver-transplantation
#3
Abbas Rana, Ellen D Witte, Karim J Halazun, Gagan K Sood, Ayse L Mindikoglu, Norman Sussman, John M Vierling, Michael L Kueht, N Thao N Galvan, Ronald T Cotton, Christine A O'Mahony, John A Goss
An index to predict hospital length of stay after liver transplantation could address unmet clinical needs. Length of stay is an important surrogate for hospital costs and efforts to limit stays can preserve our healthcare resources. Here, we devised a scoring system that predicts hospital length of stay following liver transplantation. We used univariate and multivariate analyses on 73,635 adult liver transplant recipient data and identified independent recipient and donor risk factors for prolonged hospital stay (> 30 days)...
October 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29044729/outcome-comparison-of-liver-transplantation-for-hepatitis-a-related-versus-hepatitis-b-related-acute-liver-failure-in-adult-recipients
#4
Dong-Hwan Jung, Shin Hwang, Young-Suk Lim, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Sung-Gyu Lee
Hepatitis A virus (HAV) can cause acute liver failure (ALF). This study compares outcomes between liver transplantation (LT) for HAV-related ALF (HAV-ALF) and LT for Hepatitis B virus (HBV)-related ALF (HBV-ALF). Of 3,616 adult LTs performed between January 2005 and December 2014, we performed LT for HAV-ALF recipients (n = 29) and LT for HBV-ALF recipients (n = 34). HAV-ALF group included 18 males and 11 females with mean age of 33.1 years. Graft survival rates in HAV-ALF and HBV-ALF were 65.5% and 88.0% (1 year) and 65...
October 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29044682/systematic-review-and-meta-analysis-of-liver-transplantation-using-grafts-from-deceased-donors-aged-over-70-years
#5
REVIEW
B V Dasari, H Mergental, J R Isaac, P Muiesan, D F Mirza, M T P R Perera
INTRODUCTION: Due to the current organ shortage, nearly 20% of patients die waiting for a liver transplant (LT). The average donor age is on the rise, and grafts from elderly donors are offered as extended criteria grafts. METHODS: This is a meta-analysis comparing the outcome differences of adult patients undergoing LT using grafts from <70-year-old donors versus >70-year-old donors. The primary end-points were graft and patient survival. Secondary outcomes were biliary and vascular complications as well as graft function...
October 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29032604/the-impact-of-inter-center-sharing-on-the-outcomes-of-pediatric-split-liver-transplantation
#6
Ahmed M Elsabbagh, Cassie Williams, Raffaele Girlanda, Jason Hawksworth, Alexander Kroemer, Cal S Matsumoto, Thomas M Fishbein
BACKGROUND: Split liver transplantation allows for expansion of the pool of organs available for pediatric liver transplantation. The impact of sharing segments of the same liver between centers has not been studied. STUDY DESIGN: Retrospective analysis of 24 pediatric split liver transplant cases in a recent cohort. We evaluated the outcomes of pediatric recipients who shared organs with adult patients in our own center (group A) compared to recipients who shared organs with adult patients in other centers...
October 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29032601/persistent-regional-and-racial-disparities-in-non-directed-living-kidney-donation
#7
Komal Kumar, Courtenay M Holscher, Xun Luo, Jacqueline Garonzik Wang, Saad Anjum, Elizabeth A King, Allan B Massie, James M Tonascia, Tanjala S Purnell, Dorry L Segev
Non-directed living donors (NDLD) are an important and growing source of kidneys to help reduce the organ shortage. In its infancy, NDLD transplantation was clustered at a few transplant centers and rarely benefited African American recipients. However, NDLDs have increased 9.4-fold since 2000, and now are often used to initiate kidney paired donation (KPD) chains. Therefore, we hypothesized that the initial geographic clustering and racial disparities may have improved. We used SRTR data to compare NDLDs and their recipients between 2008-2015 and 2000-2007...
October 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29032588/clinical-significance-of-lactate-clearance-for-the-development-of-early-allograft-dysfunction-and-short-term-prognosis-in-deceased-donor-liver-transplantation
#8
Deok Gie Kim, Jee Youn Lee, Yoon Bin Jung, Seung Hwan Song, Jae Geun Lee, Han Dai Hoon, Dong Jin Joo, Man Ki Ju, Gi Hong Choi, Jin Sub Choi, Myoung Soo Kim, Soon Il Kim
This retrospective study evaluated lactate clearance (LC), measured at 6, 12, 18, and 24 hours after reperfusion, as a predictor of early allograft dysfunction (EAD) and short-term outcomes in patients receiving deceased donor liver transplantation. Of 181 transplant recipients, 44 (24.3%) developed EAD and had lower LCs than those who did not develop EAD. A receiver operating characteristic analysis showed that LC determined at 6 hours showed the highest area under curve value of 0.828 (95% confidence interval [CI]: 0...
October 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29032587/team-preparation-for-human-uterus-transplantation-autologous-transplantation-in-sheep-model
#9
Evgeny Solomonov, Naama Marcus Braun, Yariv Siman-Tov, Inbar Ben Shachar
We performed autologous uterus transplantation using the living-sheep donor model for team preparation before human uterine transplantation. Five sequential operations (in 3 ewes) were prospectively conducted. Surgical technique included uterus retrieval, graft preparation, and uterus transplantation. Anastomoses were performed at the level of the external iliac. At 3 weeks follow-up, the uterus and anastomoses were checked for strictures and thrombosis. Two successful auto-transplantations were made, and one failed because of undeveloped uterine arteries (< 1 mm in diameter)...
October 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29024048/the-impact-of-adult-to-adult-living-donor-liver-transplantation-on-transplant-center-outcomes-reporting
#10
John F Renz, Geraldine C Diaz
BACKGROUND: The Scientific Registry of Transplant Recipients (SRTR) has released a 5-tier performance ranking system based upon results of deceased-donor and living-donor liver transplantation. MATERIALS AND METHODS: An analysis of Spring 2017 SRTR Program Specific Reports for outcomes of adult living-donor and deceased-donor liver transplantation. RESULTS: Utilizing the current SRTR performance algorithm, living-donor liver transplant results may disproportionately affect transplant center performance ranking...
October 12, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28990263/early-aspirin-initiation-following-heart-transplantation-is-associated-with-reduced-risk-of-allograft-vasculopathy-during-long-term-follow-up
#11
Yael Peled, Jacob Lavee, Eugenia Raichlin, Moshe Katz, Michael Arad, Yigal Kassif, Amir Peled, Elad Asher, Dan Elian, Yedael Har-Zahav, Nir Shlomo, Dov Freimark, Ilan Goldenberg, Robert Klempfner
AIM: Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality after heart transplantation (HT). Enhanced platelet reactivity is a contributing factor. We aimed to investigate the association between early initiation of aspirin therapy post-HT and the 15-year risk of the development of CAV. METHODS: We studied 206 patients who underwent HT between 1991and 2016. Multivariate Cox proportional hazards regression modeling was employed to evaluate the association between early aspirin initiation and the long-term risk of CAV...
October 9, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28990225/feasibility-of-diaphragm-pacing-in-patients-after-bilateral-lung-transplantation
#12
Dries Testelmans, Philippe Nafteux, Sophie Van Cromphaut, Bart Vrijsen, Robin Vos, Paul De Leyn, Herbert Decaluwé, Dirk Van Raemdonck, Geert M Verleden, Bertien Buyse
Recent animal studies and intra-operative studies in humans suggested that phrenic nerve stimulation could attenuate ventilator-induced diaphragm dysfunction. The purpose of the present study is to examine the safety and feasibility of diaphragm pacing during the weaning process after bilateral lung transplantation. Four patients, suffering from chronic pulmonary disease, were included, and diaphragm pacing was evaluated after lung transplantation. Implantation of electrodes at the end of the lung transplant procedure was possible in three of the four patients...
October 9, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28990220/low-dose-basiliximab-induction-therapy-in-heart-transplantation
#13
Veraprapas Kittipibul, Pakpoom Tantrachoti, Pat Ongcharit, Aekarach Ariyachaipanich, Sarawut Siwamogsatham, Supaporn Sritangsirikul, Kanokwan Thammanatsakul, Sarinya Puwanant
We prospectively studied efficacy and safety outcomes of two 10-mg doses of intravenous basiliximab on day 0 and day 4 for induction therapy in 17 consecutive de novo heart transplant recipients. By the 2-week assessment post-transplant, there were no deaths, graft failures, or acute cellular rejections (ACRs) ISHLT grade ≥ 2R. By the 1-year assessment post-transplant, there were 1 (6%) infectious death, no graft failure, 2 (12%) grade 2R ACRs, 6 (35%) asymptomatic CMV infections, and 4 (25%) treated infections...
October 9, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28972673/a-rapid-and-sustained-improvement-of-calcification-propensity-score-serum-t50-after-successful-kidney-transplantation-reanalysis-of-a-randomized-controlled-trial-of-ibandronate
#14
Knut T Smerud, Anders Åsberg, Håkon Kile, Andreas Pasch, Dag Olav Dahle, Jens Bollerslev, Kristin Godang, Anders Hartmann
A serum test called T50 assesses the overall propensity for calcification of the blood and is associated with cardiovascular outcomes. We aimed to examine T50 over time in kidney transplant recipients and also address any effects of ibandronate. Serum samples taken from kidney transplant patients included in a prospective, randomized placebo controlled study of ibandronate were analyzed in retrospect. Adequate analyses were performed at baseline (approximately 3 weeks after transplantation) in 129 patients, at 10 weeks in 127 patients and at one year in 123 patients...
October 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28972665/impact-of-machine-perfusion-after-long-static-cold-storage-on-delayed-graft-function-incidence-and-duration-and-time-to-hospital-discharge
#15
Ana Cristina Carvalho Matos, Lúcio Roberto Requiao Moura, Milton Borrelli, Mario Nogueira, Gabriela Clarizia, Paula Ongaro, Marcelino Souza Durao, Alvaro Pacheco-Silva
Delayed graft function (DGF) is very high in our center (70-80%), we usually receive a kidney for transplant after more than 22 hours of static cold ischemia time (CIT). Also, there is an inadequate care of the donors contributing to a high rate of delayed graft function (DGF). We decided to test whether machine perfusion (MP) after a cold ischemic time (CIT) improved the outcome of our transplant patients. We analyzed the incidence of DGF, its duration and the length of hospital stay (LOS) in patients who received a kidney preserved with MP after a CIT (Hybrid Perfusion - HP)...
October 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28972662/single-center-experience-in-urgent-lung-transplantation-program-in-a-country-with-a-shortage-of-donors-does-the-end-justify-the-means
#16
Marco Schiavon, Giulio Faggi, Guido Di Gregorio, Calabrese Francesca, Francesca Lunardi, Giuseppe Marulli, Paolo Feltracco, Monica Loy, Marco Damin, Emanuele Cozzi, Dario Gregori, Fiorella Calabrese, Federico Rea
In rapidly deteriorating patients awaiting lung transplantation (LT), supportive strategies are only temporary and Urgent LT (ULT) remains the last option. The few publications on this topic report conflicting results. According to the Italian national program, patients on mechanical ventilation and/or extracorporeal membrane oxygenation may be included in urgent list. We reviewed our experience from January 2012 to December 2014 with ULT and Elective LT (ELT), focusing on outcomes. In the study period, 16 patients received ULT, while 51 received ELT...
October 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28963768/reassessing-risks-and-benefits-of-living-kidney-donors-with-a-history-of-thyroid-cancer
#17
Joel T Adler, Heidi Yeh, Giuseppe Barbesino, Carrie C Lubitz
Many potential and willing living kidney donors are excluded from donating for a history of malignancy. There is appropriate caution toward patients with a history of malignancy because of concern for transmission of donor-derived malignancy. Thyroid cancer is common and increasing in incidence, and outcomes are very good in otherwise young, healthy potential donors. We review the evidence and guidelines regarding recurrence and transmission risk of thyroid cancer, and then we suggest a standardized guideline for otherwise healthy donors with a history of thyroid malignancy...
September 29, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28960504/utilization-of-high-donor-sequence-number-grafts-in-cardiac-transplantation
#18
John J Squiers, J Michael DiMaio, Giovanna Saracino, Huanying Qin, Joost Felius, Themistokles Chamogeorgakis, Juan C MacHannaford, Aldo E Rafael, Parag Kale, Susan M Joseph, Shelley A Hall, Gonzalo V Gonzalez-Stawinski, Brian Lima
Donor sequence number (DSN) represents the number of candidates to whom a graft was offered and declined prior to acceptance for transplantation. We sought to investigate the outcomes of patients receiving high DSN grafts. Consecutive isolated adult cardiac transplantations performed at a single-center were reviewed. Recipients were grouped into standard (≤75th percentile) DSN and high (>75th percentile) DSN. A previously validated donor risk index was used to quantify the risk associated with donor grafts, and recipient outcomes were assessed...
September 28, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28960455/non-traditional-sites-for-vascular-anastomoses-to-enable-kidney-transplantation-in-patients-with-major-systemic-venous-thromboses
#19
Bonnie E Lonze, Nabil N Dagher, Nada Alachkar, Annette M Jackson, Robert A Montgomery
Successful renal transplantation requires low-pressure venous drainage to permit adequate outflow from the allograft. We report here a series of three patients in whom the inferior vena cava as well as bilateral iliac veins were thrombosed, making it necessary to explore less traditional vessels for venous drainage of the renal allograft. We utilized the splanchnic vasculature in two cases, and the native left renal vein in another. The resulting atypical intra-abdominal locations of these allografts also presented difficulties for arterial anastomoses and for urinary drainage...
September 28, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28944583/venous-anastomosis-using-a-nonpenetrating-vascular-closure-system-in-orthotopic-liver-transplantation
#20
Yuan Wang, Zhao Xin, Bing Pan, Shao-Cheng Lv, Xing-Mao Zhang, Zhi-Hua Zhang, Li-Xin Li, Xian-Liang Li, Qiang He
BACKGROUND: A nonpenetrating vessel closure system (VCS-AnastoClip(®) ) may facilitate vascular anastomosis. The purpose of this study is to explore the utilization of a nonpenetrating VCS in orthotopic liver transplantation (OLT). METHODS: From January 2015 to February 2017, patients who underwent OLT were divided into two groups, i.e., those who underwent nonpenetrating VCS application for inferior vena cava (IVC) and portal vein (PV) reconstructions and those who underwent hand sewing for these purposes...
September 25, 2017: Clinical Transplantation
journal
journal
20084
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"