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Clinical Transplantation

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https://www.readbyqxmd.com/read/30536743/the-effect-of-donor-alcohol-abuse-on-outcomes-following-heart-transplantation
#1
Joshua Newman, Max Liebo, Brian D Lowes, Haseeb Ilias Basha, Yael Peled, Emily Cendrowski, Ronald Zolty, Dylan Douglas, John Y Um, Edwin McGee, Alain Heroux, Eugenia Raichlin
BACKGROUND: Current guidelines recommend against the use of hearts from donors that abuse alcohol. We explored the effect of donor alcohol abuse (AA) on cardiac allograft function and outcomes in heart transplant (HTx) recipients. METHODS: Overall, 370 HTx recipients were divided into two groups: (1) the alcoholic donor group (AD, n=58), and (2) the non-alcoholic donor group (NAD, n=312). RESULTS: Recipients in the AD group had a slower heart rate (86±13 vs...
December 11, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30506903/epidemiology-and-outcomes-of-dengue-in-kidney-transplant-recipients-a-20-year-retrospective-analysis-and-comparative-literature-review
#2
Subencha Pinsai, Sasisopin Kiertiburanakul, Siriorn P Watcharananan, Surasak Kantachuvessir, Sarinya Boongird, Jackrapong Bruminhent
BACKGROUND: Kidney transplant (KT) recipients in dengue-endemic areas are at risk of exposure. We investigated the epidemiology and outcomes from dengue in KT recipients at our transplant center and conducted a literature review. MATERIALS AND METHODS: We conducted a 20-year retrospective study of KT recipients who were diagnosed with laboratory-confirmed dengue from January 1997 to September 2017 according to the 2009 WHO classification. We analyzed clinical characteristics and treatment outcomes...
December 2, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30506888/marijuana-use-in-transplantation-a-call-for-clarity
#3
REVIEW
M E Levi, B T Montague, C Thurstone, D Kumar, S S Huprikar, C N Kotton
Transplant centers have varying policies for marijuana (MJ) use in donors, transplant candidates and recipients. Rationales for these differences range from concerns for fungal complications, impaired adherence and drug interactions. This paper reviews the current status of MJ policies and practices in transplant centers and results of a survey sent to the American Society of Transplantation (AST) membership by the Executive Committee of the AST Infectious Diseases Community of Practice. The purpose of the survey was to compare policies and concerns of MJ use to actual observed complications...
December 2, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30506808/outcomes-after-lung-transplantation-for-patients-with-occupational-lung-diseases
#4
Kyla D Joubert, J Awori Hayanga, Diane C Strollo, Elizabeth A Lendermon, Samuel A Yousem, James D Luketich, Christopher R Ensor, Norihisa Shigemura
Occupational lung diseases (OLD) including silicosis, asbestosis, and pneumoconiosis progress to end stage lung disease requiring lung transplantation (LT). Prognosis and treatment of OLDs are poorly understood and a paucity of data exists regarding LT outcomes. Additionally, transplant operative complexity for patients with OLD is high. A single center retrospective review of all single and bilateral LT recipients between May 2005 and Oct 2016 was performed. Patients were grouped by OLD, and nearest neighbor matching was performed at a ratio of 1:3 cases to controls...
December 2, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30506735/severe-hypertension-is-an-independent-risk-factor-for-posterior-reversible-encephalopathy-syndrome-post-hematopoietic-cell-transplantation-in-children-with-thalassemia-major
#5
Xin-Yu Li, Ke Huang, Dun-Hua Zhou, Yang Li, Hong-Gui Xu, Wen-Jun Weng, Lu-Hong Xu, Jian-Pei Fang
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is an increasingly recognized serious complication of Cyclosporine A (CSA) and tacrolimus (TAC) use in hematopoietic cell transplantation (HCT) recipients. PROCEDURE: A retrospective study was carried out, including 84 cases of HCT for TM from January 2012 to January 2017. 11 cases were diagnosed with PRES. RESULTS: The cumulative incidence of PRES was 13.4% (95%CI 9.7-17.2%)...
December 2, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30485535/safety-and-tolerability-of-high-intensity-statin-therapy-in-heart-transplant-patients-receiving-immunosuppression-with-tacrolimus
#6
Stephanie A Heeney, Shelby L Tjugum, Morgan E Corkish, Ian B Hollis
BACKGROUND: Following heart transplantation (HT), HMG CoA reductase inhibitors (statins) have been shown to reduce total and low-density lipoprotein (LDL) cholesterol, development of cardiac allograft vasculopathy (CAV), and mortality. Studies in HT patients have demonstrated the safety of low/moderate intensity statins, however little data exists using high intensity (HI) statins. The study aim was to evaluate the safety and efficacy of HI statins in HT recipients receiving tacrolimus...
November 28, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30472740/risk-of-adverse-maternal-and-fetal-outcomes-during-pregnancy-in-living-kidney-donors-a-matched-cohort-study
#7
Scott Davis, James Dylewski, Pratik B Shah, John Holmen, Zhiying You, Michel Chonchol, Jessica Kendrick
BACKGROUND: We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls. METHODS: Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery < 37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital > 3 days, infant death/transfer to acute facility and low birth weight (<2,500 gm)...
November 25, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30466167/lipid-lowering-in-dialysis-patients-with-cardiovascular-disease-who-are-awaiting-kidney-transplantation
#8
REVIEW
Fahad Aziz, Neetika Garg, Sandesh Parajuli, Arjang Djamali, James Stein, Didier Mandelbrot
Dyslipidemias are highly prevalent in chronic kidney disease, end-stage renal disease and kidney transplant patients. These dyslipidemias are associated with high cardiovascular risk and mortality. Many clinical trials have shown that statin therapy can significantly reduce adverse cardiovascular events in chronic kidney disease patients and kidney transplant recipients. However, three major trials did not show a benefit of statin therapy in end-stage renal disease patients on dialysis. Major guidelines either recommend against the use of statins in patients on dialysis or provide no recommendations about statin use for this complex patient population...
November 22, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30462375/prehabilitation-prior-to-kidney-transplantation-results-from-a-pilot-study
#9
Mara A McAdams-DeMarco, Hao Ying, Sarah Van Pilsum Rasmussen, Jennifer Schrack, Christine E Haugen, Nadia M Chu, Marlís González Fernández, Niraj Desai, Jeremy D Walston, Dorry L Segev
Prehabilitation is the process of enhancing pre-operative functional capacity to improve tolerance for the upcoming stressor; it was associated with improved post-operative outcomes in a handful of studies, but never evaluated in transplantation. Kidney transplant (KT) candidates may be uniquely suited for prehabilitation because they experience a profound loss of functional capacity while waiting years on dialysis. To better understand the feasibility and effectiveness of prehabilitation in KT, we conducted a pilot study of center-based prehabilitation for candidates; this intervention consisted of weekly physical therapy sessions at an outpatient center with at home exercises...
November 21, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30461073/robot-assisted-laparoscopic-versus-laparoscopic-donor-nephrectomy-in-renal-transplantation-a-meta-analysis
#10
REVIEW
Haifeng Wang, Rao Chen, Tengfang Li, Longkai Peng
BACKGROUND: Currently, the robot-assisted laparoscopic donor nephrectomy (RDN) technique is used for live donor nephrectomy. Does it provide sufficient safety and benefits for living donors? We conducted a meta-analysis to assess the safety and efficacy of RDN compared with the laparoscopic donor nephrectomy (LDN). MATERIAL AND METHODS: Eligible studies were retrieved and screened from electronic databases from 1999 onward: PubMed, Cochrane Library and Web of Science...
November 21, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30431669/implementation-of-a-transition-model-to-adult-care-may-not-be-enough-to-improve-results-national-study-of-kidney-transplant-recipients
#11
Silja Kosola, Elisa Ylinen, Patrik Finne, Kai Rönnholm, Fernanda Ortiz
Adolescents with a kidney transplant (KT) require special attention during the transition of care. Few longitudinal studies have assessed the effect of transition models (TM) on patient outcomes. Between 1986 and 2013, 239 pediatric patients underwent KT in Finland, of whom 132 have been transferred to adult care. In 2005, a TM was developed following international recommendations. We compared patient (PS) and graft survival (GS) rates before and after the introduction of the TM. PS and GS at 10 years were similar before and after the implementation of the TM (PS 85% and 90% respectively, P=0...
November 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30427068/the-impact-of-blood-pressure-variability-and-pulse-pressure-on-graft-survival-and-mortality-after-kidney-transplantation
#12
Nikolaos Pagonas, Konstantinos Markakis, Frederic Bauer, Felix S Seibert, Max Seidel, Walter Zidek, Stylianos Kykalos, Benjamin Sasko, Thomas Klein, Nina Babel, Richard Viebahn, Timm H Westhoff
BACKGROUND: Blood pressure variability and pulse pressure are strong and independent predictors of cardiovascular morbidity and mortality in the general population. So far, there are no data on the impact of blood pressure variability on mortality and graft survival after renal transplantation. METHODS: We performed a retrospective analysis of 877 patients who underwent kidney transplantation between 1997 and 2011 in two transplant centers in Germany (Berlin and Bochum) with a follow-up of 12 - 266 months...
November 14, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30421841/use-of-twitter-in-communicating-living-solid-organ-donation-information-to-the-public-an-exploratory-study-of-living-donors-and-transplant-professionals
#13
Jessica M Ruck, Macey L Henderson, Ann K Eno, Sarah E Van Pilsum Rasmussen, Sandra R DiBrito, Alvin G Thomas, Rebecca Li, Lauren Singer, Indraneel Massie, Madeleine M Waldram, Jonathan M Konel, David R Helfer, Jacqueline M Garonzik Wang, Tanjala S Purnell, Douglas B Mogul, Krista L Lentine, Amy D Waterman, Dorry L Segev
BACKGROUND: As transplant centers start leveraging Twitter for information dissemination and public engagement, it is important to understand current living solid organ donation-related Twitter use. METHODS: We identified public Twitter profiles available in 01/2017 that referenced living organ donation and analyzed use of donation-related Twitter handles, names, or profile information. Tweets were manually abstracted and qualitatively analyzed for common themes...
November 13, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30415483/lung-cancer-after-lung-transplantation-an-analysis-of-25-years-of-experience-in-a-single-institution
#14
Eva Chatron, Tristan Dégot, Elena Salvaterra, Antoine Dumazet, Michele Porzio, Sandrine Hirschi, Armelle Schuller, Gilbert Massard, Benjamin Renaud-Picard, Romain Kessler
BACKGROUND: The aim of our study was to describe the lung cancer characteristics of LTx recipients in our institution. METHODS: Between January 1, 1992 and August 15, 2017, 463 patients underwent LTx in our institution. We searched our database for patients with a post-transplant diagnosis of lung cancer. RESULTS: We found 19 LC (4.10%). 8 patients had LC in the explanted lung, 8 in the native remaining lung, and 3 in the transplanted lung...
November 11, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30412311/pain-management-and-safety-profiles-after-preoperative-versus-postoperative-thoracic-epidural-insertion-for-bilateral-lung-transplantation
#15
Andrea L Axtell, Elbert E Heng, Amy G Fiedler, Serguei Melnitchouk, David A D'Alessandro, George Tolis, Todd Astor, Adam A Dalia, Gaston Cudemus, Mauricio A Villavicencio
OBJECTIVE: Thoracic epidural analgesia provides effective pain control after lung transplantation; however, the optimal timing of placement is controversial. We sought to compare pain control and pulmonary and epidural morbidity between patients receiving preoperative versus postoperative epidurals. METHODS: Institutional records were reviewed for patients undergoing a bilateral lung transplant via a bilateral anterior thoracotomy with transverse sternotomy incision between January 2014 - January 2017...
November 9, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30408259/impact-of-hepatic-artery-size-mismatch-between-donor-and-recipient-on-outcomes-after-living-donor-liver-transplantation-using-the-right-lobe
#16
Noboru Harada, Tomoharu Yoshizumi, Hideaki Uchiyama, Yuji Soejima, Toru Ikegami, Shinji Itoh
INTRODUCTION: The aim of this study was to evaluate the effect of hepatic artery (HA) size mismatch anastomosis on outcomes after living-donor liver transplantation (LDLT). MATERIALS AND METHODS: After excluding 128 patients with the exclusion criteria among two hundred and thirty three LDLTs using the right lobe, 104 LDLT patients were divided into two groups: donor HA diameter that was greater than or equal to the recipient HA diameter (D≥R-group; n = 79), and donor HA diameter that was smaller than the recipient HA diameter (D<R-group; n = 25)...
November 8, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30408257/role-of-induction-therapy-in-low-immune-risk-kidney-transplant-recipients-a-mate-kidney-analysis
#17
Kalathil K Sureshkumar, Vinaikumar Katragadda, Bhavna Chopra, Marcelo Sampaio
We aimed to evaluate the impact of induction on outcomes in low-immunological risk kidney transplant recipients (KTRs) using a mate-kidney model. Using OPTN/UNOS database, we identified three groups of low-immune risk KTRs (first transplant, panel reactive antibody <20%, human leukocyte antigen mismatches ≤3) with each group containing recipients of mate-kidneys from same donor and differed by induction received: group1: no induction vs. interleukin-2 receptor antibody (IL2RA) induction; group2: no induction vs...
November 8, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30408245/the-fto-polymorphism-influences-the-risk-of-rejection-in-heart-transplant-patients
#18
Jaroslav A Hubacek, Jevgenija Vymetalova, Vera Lanska, Dana Dlouha
Heart transplantation is a relatively common treatment for end-stage heart failure. The major complication of heart transplantation is organ rejection. Epigenetic could play a role in the pathogenesis of organ rejection, and the FTO gene is a mediator of DNA methylation. We analysed a tagging FTO SNP rs17817449 in both donor and recipient DNA obtained through 370 heart transplantations. Recipient FTO genotypes were not associated with either type of rejection or with the general increase in the risk of rejection...
November 8, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30387908/reliability-of-deceased-donor-procurement-kidney-biopsy-images-uploaded-in-united-network-for-organ-sharing
#19
S G Mansour, I E Hall, P P Reese, Y Jia, H Thiessen-Philbrook, G Moeckel, F L Weng, P M Revelo, M A Khalighi, A Trivedi, M D Doshi, B Schröppel, C R Parikh
Prior studies demonstrate poor agreement among pathologists' interpretation of kidney biopsy slides. Reliability of representative images of these slides uploaded to the United Network of Organ Sharing (UNOS) web-portal for clinician review has not been studied. We hypothesized high agreement among pathologists' image interpretation, since static images eliminate variation induced by viewing different areas of movable slides. To test our hypothesis, we compared the assessments of UNOS-uploaded images recorded in standardized forms by three pathologists...
November 2, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/30387534/outcomes-in-human-immunodeficiency-virus-infected-recipients-of-heart-transplants
#20
Chen Chao, Xuerong Wen, Anju Yadav, Nicholas Belviso, Stephen Kogut, Jerry McCauley
BACKGROUND: With the advent of combined antiretroviral therapy (cART), growing evidence has shown Human Immunodeficiency Virus (HIV) may no longer be an absolute contraindication for solid organ transplantation. This study compares outcomes of heart transplantations between HIV positive and HIV negative recipients using SRTR transplant registry data. METHODS: Patient survival, overall graft survival and death-censored graft survival were compared between HIV positive and HIV negative recipients...
November 2, 2018: Clinical Transplantation
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