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Clinical Nuclear Medicine

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https://www.readbyqxmd.com/read/28632699/inadvertent-arterial-injection-of-123i-mibg-does-not-necessarily-cause-any-symptoms
#1
Wei Zhang, Hongming Zhuang
An I-MIBG scan was obtained to evaluate a right adrenal mass in a 10-year-old boy, which showed no elevated activity in the lesion. However, diffuse increased activity was noted in the right forearm with typical manifestation of an "arterial injection." Different from a prior case report, no symptoms or signs related to arterial injection were observed in our patient.
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632698/primary-cutaneous-angiosarcoma-mimicking-metastasis-on-18f-fdg-pet-ct-in-woman-with-cervix-cancer
#2
Jae Pil Hwang
Primary cutaneous angiosarcoma is a rare vascular tumor usually affecting the whole body, and its hypermetabolic features on F-FDG PET/CT may be confused with those of infection, metastasis, or primary malignancy. This is a case report of a cutaneous angiosarcoma of the lower anterior abdomen showing increased FDG uptake on F-FDG PET/CT mimicking a cutaneous metastasis in an 84-year-old woman with cervical cancer.
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632697/increased-activity-in-the-lung-field-on-gastroesophageal-scintigraphy-is-not-always-due-to-aspiration
#3
Xiaofei Zhao, Hongming Zhuang
Elevated activity in the lung field on gastroesophageal scintigraphy (milk scan) generally indicates aspiration of the gastric content that has refluxed to the pharynx. An 18-year-old man underwent to gastroesophageal scintigraphy to assess the rate of gastric emptying. Increased activity was noted in the left lower lung field during the image acquisition. Careful analysis of the images showed that this activity was caused by hiatal herniation.
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632696/infection-of-ventricular-assist-device-detected-and-monitored-by-18f-fdg-pet-ct
#4
Sébastien Dejust, Renaud Guedec-Ghelfi, Estelle Blanc-Autrant, Yannick Lepers, David Morland
We report a case of a 59-year-old man who presented with fever, sepsis, and left cervicothoracic cutaneous inflammation 13 months after implantation of Jarvik 2000 device. Device infection was suspected and F-FDG PET/CT showed an intense and homogeneous uptake along driveline cable. Bacteriological local sample showed Staphylococcus aureus. After adapted antibiotherapy, control F-FDG PET/CT displays treatment efficacy with no residual uptake in driveline. F-FDG PET/CT could be an important tool for early noninvasive detection of left ventricular assist device infection and monitoring antibiotherapy response...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632695/serum-ceruloplasmin-and-striatal-dopamine-transporter-density-in-parkinson-disease-comparison-with-123i-fp-cit-spect
#5
Yoo Sung Song, Jong-Min Kim, Kyeong Joon Kim, Ji Young Yun, Sang Eun Kim
PURPOSE: In patients with Parkinson disease (PD), decreased serum ceruloplasmin levels have been observed. This study investigated a correlation between serum ceruloplasmin-along with its related serum markers- and striatal presynaptic dopaminergic denervation measured with I-FP-CIT SPECT. METHODS: We analyzed a total of 141 de novo patients divided into 2 groups: the PD group (107 patients with PD) and the disease control group (34 patients with vascular pseudoparkinsonism, essential tremor, or drug-induced parkinsonism)...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632694/multiorgan-involvement-of-chemotherapy-induced-sarcoidosis-mimicking-progression-of-lymphoma-on-fdg-pet-ct
#6
Prateek Sanan, Yang Lu
A 35-year-old woman with biopsy-proven recurrent Hodgkin lymphoma in the neck lymph nodes received salvage chemotherapy of brentuximab/insulin growth factor-methotrexate. Although the patient continued doing well clinically with no constitutional symptoms or significant laboratory abnormalities following the second recurrence, subsequent FDG PET CT examinations over the next 2 years revealed multiple new FDG-avid foci including lymph nodes above/below the diaphragm, liver, spleen, lungs, and bone. An alternate diagnosis of chemotherapy-induced sarcoidosis was suggested and confirmed on both bone marrow and right inguinal node biopsy...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632693/extraosseous-extension-of-aggressive-vertebral-hemangioma-as-a-potential-pitfall-on-68ga-psma-pet-ct
#7
Stephan Probst, Franck Bladou, Gad Abikhzer
A 74-year-old man with newly diagnosed prostate cancer underwent Ga-PSMA PET/CT, which demonstrated intense uptake in and adjacent the L2 vertebral body. Subsequent MRI of the lumbar spine showed an aggressive L2 hemangioma with adjacent soft tissue extension. There was congruence of the intraosseous and extraosseous components of the hemangioma and the PSMA PET uptake. This is a rare but important potential pitfall in Ga-PSMA PET/CT-a soft tissue lesion with intense tracer uptake related not to a nodal metastasis of prostate cancer but to extraosseous extension of an aggressive vertebral body hemangioma...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632692/improved-123i-ioflupane-binding-after-immunotherapy-in-anti-nae-antibody-positive-hashimoto-encephalopathy-that-clinically-mimicked-multiple-system-atrophy
#8
Juuri Otsuka, Ayumi Hida, Kamiyu Ogyu, Ryogo Minamimoto, Sousuke Takeuchi
We describe an 84-year-old man with anti-NH2-terminal of α-enolase antibody-positive Hashimoto encephalopathy that clinically mimicked multiple system atrophy who underwent investigation by dopamine transporter SPECT before and after immunotherapy. Before treatment, dopamine transporter SPECT showed reduced striatal I-ioflupane binding, with a mean specific binding ratio of 2.42, even though he had no apparent parkinsonism. After immunotherapy, mean specific binding ratio was improved to 3.22. Dopamine transporter SPECT was useful in this case to detect subclinical striatal dysfunction, and evaluation both before and after immunotherapy helped to distinguish between neurodegenerative disease and neuroimmunological disorder...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632691/18f-fdg-uptake-in-benign-fibrous-histiocytoma-of-adrenal-gland-a-potential-pitfall
#9
Teik Hin Tan, Christina Nye Bing Lai
A 47-year-old man with newly diagnosed nasopharyngeal carcinoma underwent staging F-FDG PET/CT. Apart from showing increased FDG uptake in the primary site and locoregional nodal and liver metastases, an unusual site of intense FDG focus was demonstrated in the left adrenal gland. He underwent CT-guided biopsy, and the histopathologic diagnosis was benign fibrous histiocytoma.
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632690/noninvasive-nuclear-spect-myocardial-blood-flow-quantitation-to-guide-management-for-coronary-artery-disease
#10
Lung-Ching Chen, Bor-Hsin Jong, Sheng-Che Lin, Chi-Tai Ku, Ing-Jou Chen, Yen-Kung Chen, Bailing Hsu
Recently, myocardial blood flow quantitation with dynamic SPECT has been validated to enhance the detection of multivessel coronary artery disease (CAD) and conclude equivocal SPECT myocardial perfusion study. This advance opened an important clinical application to utilize the tool in guiding CAD management for area where myocardial perfusion tracers for PET are unavailable or unaffordable. We present a clinical patient with ongoing recursive angina who underwent multiple nuclear stress tests for a sequence of CAD evaluation in 26 months and demonstrated that SPECT myocardial blood flow quantitation properly guided CAD management to warrant patient outcome...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632689/18f-fdg-uptake-in-ischemic-colitis-during-follow-up-of-a-patient-with-lung-cancer
#11
Sofia C Vaz, Carla Oliveira, Joana C Castanheira, Ângelo F Silva, Durval C Costa
A 61-year-old man with previous history of lung adenocarcinoma underwent 2 F-FDG PET/CT investigations. The first for assessment of enlarged mediastinal lymph nodes revealed an area of increased FDG uptake in the sigmoid colon (located at the right pelvis). Colonoscopy showed a segmental area of ischemic sigmoid colitis, confirmed on histology postbiopsy. The asymptomatic man had no risk factors, and no specific treatment was administered, apart from supportive measures. One year later, there was no significantly abnormal uptake on PET/CT...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28604480/intense-muscle-activity-due-to-polymyositis-incidentally-detected-in-a-patient-evaluated-for-possible-malignancy-by-fdg-pet-ct-imaging
#12
Xia Bai, Ning Tie, Xuemei Wang, Jianmin Zhao
A 42-year-old woman suffered shortness of breath and whole-body pain, more prominent in both thighs. After the initial assessment, a paraneoplastic syndrome was considered clinically, and FDG PET/CT was performed to search culprit malignancy. The images did not reveal any focal lesion typical of solid hypermetabolic malignancy. Instead, diffuse increased muscle activity was noted in most musculatures, with some focally intense. The findings were suggestive of polymyositis, which was subsequently confirmed.
June 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28604479/18f-fes-pet-has-added-value-in-staging-and-therapy-decision-making-in-patients-with-disseminated-lobular-breast-cancer
#13
Clasina Venema, Erik de Vries, Andor Glaudemans, Boelo Poppema, Geke Hospers, Carolina Schröder
Lobular breast cancer is the second most common type of invasive breast cancer. Lobular breast cancer lesions are often difficult to detect with conventional imaging because they tend to grow less cohesively than ductal cancer. These images represent 3 lobular breast cancer cases, in whom confirmation of metastatic disease would make the crucial difference between curative or noncurative treatment. Staging with conventional imaging, however, yielded equivocal results, and a biopsy was not feasible. In contrast, FES (16α-[F]fluoro-17β-estradiol) PET provided a decisive contribution to clinical decision making in these patients...
June 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28604478/fdg-pet-ct-image-of-seminoma-in-androgen-insensitivity-syndrome
#14
Eun Ji Han, Joo Hyun O, Gun Park, Junguee Lee
We report the FDG PET/CT findings of seminoma in a 21-year-old woman with androgen insensitivity syndrome. PET images showed focal FDG uptake in the left pelvic sidewall, and a hypodense lesion with calcifications was noted in the corresponding CT images. Another smaller hypodense lesion with calcifications was noted in the right pelvic sidewall, but faint FDG uptake. Laparoscopic surgery was performed, and both lesions were pathologically confirmed as seminomas.
June 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28604477/multicenter-comparison-of-contrast-enhanced-fdg-pet-ct-and-64-slice-multi-detector-row-ct-for-initial-staging-and-response-evaluation-at-the-end-of-treatment-in-patients-with-lymphoma
#15
Nieves Gómez León, Roberto C Delgado-Bolton, Lourdes Del Campo Del Val, Beatriz Cabezas, Reyes Arranz, Marta García, Jimena Cannata, Saturnino González Ortega, Mª Ángeles Pérez Sáez, Begoña López-Botet, Beatriz Rodríguez-Vigil, Marta Mateo, Patrick M Colletti, Domenico Rubello, José L Carreras
OBJECTIVES: To compare staging correctness between contrast-enhanced FDG PET/ceCT and 64-slice multi-detector-row CT (ceCT64) for initial staging and response evaluation at the end of treatment (EOT) in patients with Hodgkin lymphoma, diffuse large B cell lymphoma (DLBCL), and follicular lymphoma. METHODS: This prospective study compared initial staging and response evaluation at EOT. One hundred eighty-one patients were randomly assigned to either ceCT64 or FDG PET/ceCT...
June 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28604476/pet-mr-in-the-assessment-of-pediatric-histiocytoses-a-comparison-to-pet-ct
#16
Andrew C Sher, Robert Orth, Kenneth McClain, Carl Allen, Shireen Hayatghaibi, Victor Seghers
PURPOSE: The aim of this study was to analyze the feasibility and diagnostic performance of F-FDG PET/MR compared with F-FDG PET/CT in a cohort of pediatric histiocytosis patients with regard to image quality, lesion detection, and FDG quantification. METHODS: Children with a diagnosis of Langerhans cell histiocytosis or Rosai-Dorfman disease were prospectively recruited. Seventeen PET/CT and PET/MR examinations were performed on 9 patients (mean age, 6.2 years) following a single-injection dual-imaging protocol...
June 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28590301/epstein-barr-virus-positive-mucocutaneous-ulcer-mimicking-rectal-carcinoma-at-18f-fdg-pet-ct
#17
Anna Margherita Maffione, Lucia Rampin, Rossella Paolini, Elisabetta Rodella, Laura Camilla Lisato, Maria Rosa Ballotta, Giovanni Pavanato, Giampaolo Montesi, Patrick M Colletti, Domenico Rubello
We report focally intense F-FDG PET/CT rectal activity (SUVmax = 25) with a horseshoe distribution in an 81-year-old man with B-cell chronic lymphocytic leukemia and suspected Richter transformation. While imaging findings were typical for rectal adenocarcinoma, histology revealed Epstein-Barr virus-positive mucocutaneous ulcer.
June 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28590300/18f-fdopa-pet-imaging-in-prolactinoma
#18
Merwan Ginet, Thomas Cuny, Emmanuelle Schmitt, Pierre-Yves Marie, Antoine Verger
Pituitary macroadenoma constitutes a frequently misdiagnosed benign tumor. We report herein a case where such macroadenoma, a prolactinoma, was incidentally discovered in a 63-year-old man who had been referred to F-FDG PET and F-FDOPA PET imaging for a pharmacoresistant epilepsy. An increased uptake was documented for both radiotracers within the sellar region, although with a much higher contrast for F-FDOPA than for F-FDG. This case presents an increased uptake documented within a prolactinoma owing to the high contrast and image quality provided by F-FDOPA PET...
June 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28590299/18f-fdg-pet-ct-in-the-detection-of-undifferentiated-carcinoma-with-osteoclast-like-giant-cells-of-the-pancreas
#19
Li-Ping Fu, Ai-Ping Cheng, Xiao-Gang Wang, Jian-Lan Fu, Li Jin
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is a rare nonendocrine pancreatic tumor. We present a case of a very small UCOGCP. F-FDG PET/CT revealed a solid mass measuring 1.0 × 0.8 cm on CT images with an SUVmax of 5.0 in the body of the pancreas. CT revealed a solid mass with significant enhancement. The histopathologic and immunohistochemical studies confirmed the diagnosis. Our findings indicate F-FDG PET/CT is a useful imaging modality for UCOGCP diagnosis.
June 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28590298/diagnostic-and-prognostic-implications-of-exercise-treadmill-and-rest-first-pass-radionuclide-angiography-in-patients-with-pulmonary-hypertension
#20
Yen-Wen Wu, Pei-Ying Hsu, Yen-Hung Lin, Mei-Fang Cheng, Chi-Lun Ko, Yih-Hwen Huang, Ruoh-Fang Yen, Jin-Shing Chen, Jou-Wei Lin, Hsao-Hsun Hsu
PURPOSE: Pulmonary hypertension (PH) is characterized by abnormally increased pulmonary vascular pressure, leading to deteriorated right ventricular function and premature death. Pulmonary mean transit time (PMTT) and biventricular function response to exercise in first-pass radionuclide angiography (FP-RNA) may provide early detection and timely disease monitoring of PH. This study aimed to investigate the diagnostic and prognostic values of this imaging modality in PH patients. METHODS: Left and right ventricular ejection fraction (LVEF/RVEF) and PMTT at rest and immediately after exercise treadmill test were measured by FP-RNA in 77 consecutive patients with clinical presentations suggestive of PH (aged 46 ± 15 years, 33 men), mostly with symptoms of unexplained progressive dyspnea...
June 5, 2017: Clinical Nuclear Medicine
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