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Clinical Nuclear Medicine

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https://www.readbyqxmd.com/read/30516690/incidental-finding-of-intrathyroid-metastases-of-prostatic-cancer-on-18f-choline-pet-ct
#1
Lavinia Vija Racaru, Erwan Gabiache, Sebastien Fontaine, Dominique DʼAure, Loic Mourey, Frederic Courbon, Slimane Zerdoud
An 85-year-old man with a 2-year history of prostate cancer, treated with radiotherapy and hormonal therapy, presented increased prostatic-specific antigen levels. F-choline PET/CT showed focal prostatic uptake consistent with known local recurrence, increased uptake of 2 hypodense thyroid nodules and of 2 left cervical lymph nodes, suspected as thyroid cancer. Neck ultrasound confirmed the high risk of malignancy, and a guided biopsy (of a thyroid nodule and cervical lymph node) revealed cellular infiltrates thyroid transcription factor-1 (TTF-1) negative and prostatic-specific antigen positive, confirming intrathyroid and cervical lymph node metastases of prostate cancer...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516689/fdg-pet-ct-for-detecting-an-infection-focus-in-patients-with-bloodstream-infection-factors-affecting-diagnostic-yield
#2
Jordy P Pijl, Andor W J M Glaudemans, Riemer H J A Slart, Derya Yakar, Marjan Wouthuyzen-Bakker, Thomas C Kwee
PURPOSE: To investigate the diagnostic performance of F-fluoro-2-deoxy-D-glucose (FDG) PET/ CT for the detection of an infection focus in patients with a bloodstream infection (BSI) and to identify factors influencing the diagnostic yield of FDG-PET/CT. METHODS: This retrospective single-center study included 185 consecutive patients with a BSI who underwent an FDG-PET/CT scan for the detection of an infection focus between 2010 and 2017. The final diagnosis at hospital discharge was used as reference standard...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516688/99mtc-mibi-uptake-in-a-benign-thymic-cyst
#3
Hwan Lee, Christopher R Gault, Gang Cheng, Jagruti C Shah, Austin R Pantel
A 34-year-old man with end-stage renal failure status post rejection of a deceased donor kidney transplant presented with bone pain in the setting of elevated serum parathyroid hormone and calcium levels. A Tc-MIBI SPECT/CT was performed before planned subtotal parathyroidectomy. SPECT/CT imaging revealed a 1.9-cm anterior mediastinal lesion with radiotracer uptake on both the immediate and delayed images. Surgical pathology of the lesion showed a benign thymic cyst with no parathyroid component.
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516687/primary-diffuse-leptomeningeal-melanomatosis-of-spine-18f-fdg-pet-findings
#4
Asli Ayan, Aylin Akbulut, Guzin Deveci, Gokhan Koca
Primary diffuse leptomeningeal melanomatosis is a rare variant of malignant melanoma of the central nervous system, arising from melanocytes of leptomeninges. It may involve leptomeninges and may invade brain superficially. The diagnosis of the disease with conventional imaging techniques is quite difficult. This case demonstrates the F-FDG uptake of primary diffuse leptomeningeal melanomatosis matching with MRI contrast enhancement regions particularly in the lower thoracic and superior lumbar region.
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516686/voriconazole-induced-periostitis-after-allogeneic-stem-cell-transplantation
#5
Maarten Haemels, Steven Pans, Hélène Schoemans, Karolien Goffin, Olivier Gheysens, Sander Jentjens
A 34-year-old man with history of Hodgkin lymphoma presented 7 months after allogeneic stem cell transplantation with an unexplained severe musculoskeletal pain syndrome. A Tc-MDP bone SPECTCT showed multiple foci with moderate to intense bone uptake across the axial and appendicular skeleton consistent with periostitis. The patient had been on voriconazole daily for 4 months to treat an Aspergillus pneumonia, and in the absence of other causes, a drug-induced periostitis was suspected. Voriconazole was changed to posaconazole with complete resolution of the musculoskeletal symptoms within 3 weeks...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516685/juvenile-nasal-angiofibroma-on-68ga-psma-pet-ct-opening-new-frontiers
#6
Pirabu Sakthivel, Arun Prashanth, Alok Thakar, Rajeev Kumar, Rakesh Kumar
The prostate-specific membrane antigen (PSMA) is highly expressed in prostatic cancer. However, PSMA expression is also noted in various benign and malignant nonprostatic neoplasms in the endothelial cells of tumor-associated neovasculature. We performed Ga-PSMA PET/CT in a 14-year-old boy with juvenile nasal angiofibroma (JNA) to explore its theranostic potential. The scan revealed high uptake in the lesion. Performance of PSMA PET/CT in JNA opens up new frontiers with respect to radiological staging, early recurrence identification, and perhaps even radioligand therapy of residual/recurrent JNAs in the future...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516684/evaluation-of-oxalate-osteopathy-secondary-to-hyperoxaluria-with-18f-fdg-pet-ct-and-99mtc-hmdp-bone-scan
#7
François Somme, Cyrille Blondet, Julien Matuszak, Céline Heimburger
We report a case of a 69-year-old woman with primary hyperoxaluria type I, who developed a severe hypercalcemia despite controlled secondary hyperparathyroidism. Bone scintigraphy showed diffuse increased uptake in axial and peripheral skeleton. F-FDG PET/CT showed countless striking hypermetabolic foci, interesting 2 types of lesions (joint calcifications and periosteal resorptions). Bone biopsy demonstrated inflammatory changes around many calcium oxalate crystals; hypercalcemia was then related to oxalate osteopathy...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516683/diffuse-large-b-cell-lymphoma-recurring-as-neurolymphomatosis-on-fdg-pet-ct
#8
Rueben Ganeshalingam, Paul Roach, Geoffrey Paul Schembri
Two patients with diffuse large B-cell lymphoma relapsing as neurolymphomatosis diagnosed on FDG PET/CT are presented. Both patients were treated initially with chemotherapy and had a complete metabolic response. Patient 1 represented with lower-limb pain. An FDG PET/CT demonstrated intense uptake throughout the sciatic nerves bilaterally extending distally with relapse confirmed on biopsy. Patient 2 represented to hospital with worsening mobility, neuropathic pain, and facial asymmetry. An FDG PET/CT demonstrated relapse within the spinal cord, left sciatic nerve, and facial nerve branches...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516682/subacute-venous-infarct-mimicking-cerebral-metastasis-in-18f-fdg-pet-ct
#9
Cihan Gündoğan, Aytül Hande Yardimci, Burçak Yilmaz Güneş, Tevfik Fikret Çermik
A 68-year-old woman with colon carcinoma was referred to F-FDG PET/CT imaging for staging. In addition to primary tumor involvement, PET/CT demonstrated focal FDG uptake in the right temporal lobe suggestive of primary brain tumor or metastasis. To delineate the lesion, a brain MRI scan showed sigmoid sinus thrombosis and vasogenic edema in the right temporal lobe. The patient presented a history of right-sided headache that began 1 week before the PET/CT. Neurological examination and MRI findings were concluded as subacute venous infarct due to sigmoid sinus thrombosis and that is a potential cause for false-positive FDG uptake on PET/CT...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516681/ischemic-complications-after-high-grade-glioma-resection-could-interfere-with-residual-tumor-detection-with-18f-fluorocholine-pet-ct
#10
Ana María García Vicente, María José Rodriguez Muñoz, Francisco José Pena Pardo, Milton Miguel Martinez Madrigal, Angel Soriano Castrejón
Ischemic complications after resection of high-grade glioma are frequent and may constitute potential cause of false-positive results in postsurgical evaluation using F-fluorocholine PET/CT. On the other hand, hypoxia caused by ischemia promotes invasive glioma growth. We present 3 cases of patients with different grades of ischemic injury after resection of high-grade glioma. The combined interpretation of diffusion-weighted imaging and apparent diffusion coefficient map on MRI, in this clinical setting, is mandatory to avoid PET/CT misinterpretations...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516680/richter-syndrome-presenting-with-colon-localization
#11
Mariadea Lavalle, Laura Maria Minordi, Stefan Hohaus, Riccardo Manfredi, Vittoria Rufini
A 75-year-old man, who had been diagnosed with small lymphocytic lymphoma with cervical localization, underwent F-FDG PET/CT with iodinated contrast medium due to the appearance of cervical swelling suspected of illness relapse. PET/CT revealed intense F-FDG uptake in multiple cervical and subdiaphragmatic lymph nodes and in the left parotid. Moreover, diffuse uptake and wall thickening of the colon were evident; endoscopy with biopsy revealed a diffuse large B-cell lymphoma. Transformation into a more aggressive lymphoma occurs in 2% to 8% of small lymphocytic lymphoma, the so-called Richter syndrome...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516679/pretreatment-tumor-18f-fdg-uptake-improves-risk-stratification-beyond-recist-1-1-in-patients-with-advanced-nonsquamous-non-small-cell-lung-cancer-fdg-uptake-and-risk-stratification
#12
Seung Hwan Moon, Jong-Mu Sun, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn, Joon Young Choi
PURPOSE: This study investigated the prognostic role of tumor F-FDG uptake on pretreatment scans as an independent indicator and whether its addition improves risk prediction from Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1). METHODS: We measured the SUVmax of the most F-FDG-avid tumor lesions on pretreatment scans from 222 patients (age, 60.5 ± 9.5 years; males, 55.2%) with advanced nonsquamous non-small-cell lung cancer who were enrolled in a prospective phase II clinical trial...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516678/68ga-dota-toc-pet-ct-of-von-hippel-lindau-disease
#13
Virginia Liberini, Daniele Giovanni Nicolotti, Mauro Maccario, Monica Finessi, Désirée Deandreis
We present a rare case of a 42-year-old man with a long history of von Hippel-Lindau disease that was scanned with Ga-DOTA-TOC PET/CT for suspicion of disease relapse. Ga-DOTA-TOC imaging demonstrated increased DOTA-TOC uptake in pancreas tail and intramedullary and extramedullary spinal hemangioblastomas, only some of which have already been highlighted at MRI examination. This case illustrates the significant role the Ga-labeled somatostatin receptor analogs PET/CT in the management of the von Hippel-Lindau disease...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516677/arterial-phase-18f-fluorocholine-pet-ct-in-hepatocellular-carcinoma
#14
Alexandre Legendre, Guillaume Collet, Hélène Lahousse, Anne-Laure Aziz, Grégory Petyt
A 57-year-old man was referred to our institution for F-fluorocholine PET/CT to characterize a pulmonary nodule in a context of hepatocellular carcinoma. F-FDG PET/CT did not show any uptake of the pulmonary nodule. F-fluorocholine PET/CT showed high uptake of the pulmonary nodule, confirming its metastatic origin. Furthermore, liver early dynamic acquisitions allowed better visualization of the hepatocellular carcinoma during the "arterial phase" than at equilibrium.
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516676/18f-fdg-pet-and-bone-scintigraphy-of-epithelioid-hemangioendothelioma
#15
Marc-Antoine Hubaut, Alice Jaillard, Capucine Eloy, Gregory Petyt
We report the case of a 31-year-old woman with left foot bones located epithelioid hemangioendothelioma. It is a rare type of vascular tumor, locally aggressive with metastatic potential. It was revealed by a chronic isolated left foot pain. Conventional imaging showed multiple osteolytic lesions of the bones, appearing aggressive. Both bone scintigraphy and F-FDG PET showed an increased uptake of these lesions and confirmed the limited extent to distal extremity of the left lower limb. Final diagnosis was given on a surgical biopsy...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516675/hybrid-11c-met-pet-mri-combined-with-machine-learning-in-glioma-diagnosis-according-to-the-revised-glioma-who-classification-2016
#16
Sied Kebir, Manuel Weber, Lazaros Lazaridis, Cornelius Deuschl, Teresa Schmidt, Christoph Mönninghoff, Kathy Keyvani, Lale Umutlu, Daniela Pierscianek, Michael Forsting, Ulrich Sure, Martin Stuschke, Christoph Kleinschnitz, Björn Scheffler, Patrick M Colletti, Domenico Rubello, Christoph Rischpler, Martin Glas
PURPOSE: With the advent of the revised WHO classification from 2016, molecular features, including isocitrate dehydrogenase (IDH) mutation have become important in glioma subtyping. This pilot trial analyzed the potential for C-methionine (MET) PET/MRI in classifying glioma according to the revised WHO classification using a machine learning model. METHODS: Patients with newly diagnosed WHO grade II-IV glioma underwent preoperative MET-PET/MRI imaging. Patients were retrospectively divided into four groups: IDH wild-type glioblastoma (GBM), IDH wild-type grade II/III glioma (GII/III-IDHwt), IDH mutant grade II/III glioma with codeletion of 1p19q (GII/III-IDHmut1p19qcod) or without 1p19q-codeletion (GII/III-IDHmut1p19qnc)...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516674/unusual-focal-muscle-fdg-activity-related-to-altered-biomechanics
#17
Eleanor Gillis, Zhe Wen, Hongming Zhuang
A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. The resected lesion was pathologically proven as periosteal chondrosarcoma instead of periosteal osteosarcoma. In a follow-up period of 4 years after the surgery, there was no recurrent disease, nor any abnormality in the muscles which showed focal FDG activity on the initial FDG PET/CT...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516673/rationale-for-study-of-the-deep-subfascial-lymphatic-vessels-during-lymphoscintigraphy-for-the-diagnosis-of-peripheral-lymphedema
#18
Corrado Cesare Campisi, Melissa Ryan, Giuseppe Villa, Pietro Di Summa, Mario Cherubino, Francesco Boccardo, Corradino Campisi
PURPOSE: The current study aimed to determine the utility of including the study of deep subfascial lymphatic vessels in a 2-compartment lymphoscintigraphy for the diagnosis of lymphedema in patients with limb swelling. Lymphoscintigraphy is a valuable imaging tool for the timely diagnosis of peripheral lymphedema. However, there is a lack of standardization in its application, especially regarding which type of lymphatic vessels to examine (superficial, deep, or both). METHODS: Two hundred fifty-eight patients with lymphedema underwent segmental lymphoscintigraphy...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516672/incidental-18f-naf-uptake-in-drug-induced-gynecomastia
#19
Esha Kothekar, William Y Raynor, Abdullah Al-Zaghal, Thomas J Werner, Abass Alavi
Gynecomastia is not uncommon in men older than 50 years of age and is characterized by glandular proliferation of breast tissue. Non-physiologic gynecomastia is mostly caused by a variety of external medical interventions. Medications that belong to classes of antiandrogens, antipsychotics, or antibiotics alter the levels of estrogen and testosterone and are commonly implicated in patients with gynecomastia. We are presenting a case of bilateral F-NaF uptake in the breast tissue of a 56-year-old man with known history of prostate cancer...
December 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30516671/increased-99mtc-pertechnetate-uptake-but-unimpressive-131i-activity-in-the-metastatic-mediastinal-lymph-nodes-in-a-thyroid-cancer-patient
#20
Fuqiang Shao, Dan Zhou, Xiaoli Lan
False negative I accumulation in metastatic lesions of thyroid carcinoma could be due to various etiologies. Here we present a 33-year-old woman with a history of papillary thyroid cancer who had increased Tc pertechnetate activity in the mediastinal metastatic lymph nodes, which was not clearly seen on whole body I scan due to adjacent activity from lung metastases.
December 3, 2018: Clinical Nuclear Medicine
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