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Clinical Nuclear Medicine

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https://www.readbyqxmd.com/read/28319505/18f-naf-pet-ct-in-extensive-melorheostosis-of-the-axial-and-appendicular-skeleton-with-soft-tissue-involvement
#1
Georgios Z Papadakis, Smita Jha, Timothy Bhattacharyya, Corina Millo, Tsang-Wei Tu, Ulas Bagci, Kostas Marias, Apostolos H Karantanas, Nicholas J Patronas
Melorheostosis is a rare, nonhereditary, benign, sclerotic bone dysplasia with no sex predilection, typically occurring in late childhood or early adulthood, which can lead to substantial functional morbidity, depending on the sites of involvement. We report on a patient with extensive melorheostosis in the axial and appendicular skeleton, as well as in the soft tissues, who was evaluated with whole-body F-NaF PET/CT scan. All melorheostotic lesions of the skeleton and of the ossified soft-tissue masses demonstrated intensely increased F-NaF activity, suggesting the application of this modality in assessing and monitoring the disease activity...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319504/re-increased-18f-2-fluorodeoxysorbitol-18f-fds-activity-in-a-pituitary-spindle-cell-carcinoma
#2
Mehrbod S Javadi, Alvaro A Ordonez, Sanjay K Jain
No abstract text is available yet for this article.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319503/myocardial-infarction-in-a-patient-with-hypertrophic-cardiomyopathy-but-normal-coronary-arteries
#3
Shuheng Li, Xiaoxin Sun, Zongyao Zhang, Zuo-Xiang He
A 57-year-old man with a history of hypertrophic cardiomyopathy diagnosed by echocardiography experienced atypical chest pain and dyspnea for 6 months. A rest Tc-MIBI myocardial SPECT imaging and a F-FDG myocardial PET/CT imaging were performed, which showed multiple matched myocardial perfusion/metabolism defects in the left ventricle, indicating scar tissue. Surprisingly, subsequent contrast coronary angiography revealed no significant coronary artery stenosis.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319502/remitting-seronegative-symmetrical-synovitis-with-pitting-edema-appearance-on-fdg-pet-ct
#4
Jianjie Wang, Chaoyu Pu, Zhenchang Wang, Jigang Yang
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare condition in the elderly and can appear as a first presentation of various types of rheumatic and malignant diseases. We presented a 62-year-old man with the diagnosis of RS3PE based on the clinical sign and laboratory data. Because of the possibility of associated malignancies in RS3PE, FDG PET/CT was performed to exclude occult tumors. The images showed multiple, symmetrically, diffusely increased F-FDG uptake in the soft tissue around joints and bones in the shoulders, hips, knees, and ankles...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319501/18f-fluorocholine-pet-ct-brain-mri-and-5-aminolevulinic-acid-for-the-assessment-of-tumor-resection-in-high-grade-glioma
#5
Ana María García Vicente, Fátima Jiménez Aragón, Maikal Villena Martín, German Andrés Jiménez Londoño, Jose María Borrás Moreno
High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome. We present the case of a 57-year-old man with a brain lesion suggestive of high-grade glioma. Brain MRI and F-fluorocholine PET/CT were performed previously to plan the surgery. Surgery was microscope assisted after the administration of 5-aminolevulinic acid. Postsurgery brain MRI and PET were blind evaluated to the surgery results and reported as probably gross total resection.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319500/clinical-response-profile-of-metastatic-advanced-pulmonary-neuroendocrine-tumors-to-peptide-receptor-radionuclide-therapy-with-177lu-dotatate
#6
Rahul V Parghane, Sanjay Talole, Kumar Prabhash, Sandip Basu
OBJECTIVES: The aims of this study were to perform multiparametric response assessment of metastatic/advanced pulmonary neuroendocrine tumors (NETs) to Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) (clinical, biochemical, molecular/structural imaging, and survival assessment) and to study the relationship between response, mortality, and overall survival with dual-tracer molecular imaging parameters. METHODS: Twenty-two patients (6 women, 16 men; median age, 44 years; range, 16-72 years) of histopathologically proven pulmonary NETs with metastatic/advanced disease were included and analyzed retrospectively...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319499/developmental-venous-anomalies-mimicking-neoplasm-on-11c-methionine-pet-and-dsc-perfusion-mri
#7
Julie H Harreld, Mikhail Doubrovin, Elizabeth R Butch, Angela Edwards, Barry Shulkin
Elevated relative cerebral blood volume on perfusion MRI and increased uptake on C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319498/fdopa-patterns-in-adrenal-glands-a-pictorial-essay
#8
Aurélie Moreau, Anne Laure Giraudet, David Kryza, Françoise Borson-Chazot, Claire Bournaud-Salinas, Thomas Mognetti, Jean-Christophe Lifante, Patrick Combemale, Francesco Giammarile, Claire Houzard
F-FDOPA is a well-established tool to explore pheochromocytomas. It tends to replace I-MIBG scan in metastatic pheochromocytomas, multiple endocrine neoplasia type 2-related tumors, succinate dehydrogenase [ubiquinone] iron-sulfur subunit-negative tumors, and succinate dehydrogenase[ZERO WIDTH SPACE]-positive lesions. To our knowledge, no study has characterized physiological and pathological adrenal glands with F-FDOPA from a quantitative point of view. We report the features of different normal and pathological adrenal glands with F-FDOPA...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319497/vertebral-hemangioma-mimicking-bone-metastasis-in-68ga-psma-ligand-pet-ct
#9
Carlos Artigas, François-Xavier Otte, Marc Lemort, Roland van Velthoven, Patrick Flamen
Ga-PSMA PET/CT was performed in a 68-year-old man to evaluate recurrent prostate cancer due to elevated serum prostate-specific antigen level. Images showed a focal uptake in the prostatic gland, suggesting local relapse, and an intense uptake in the 12th thoracic vertebra, with no morphological abnormalities in CT slices. In order to confirm extraprostatic disease and before radiotherapy planning, a full-spine MRI was performed, resulting with the morphological pattern of a vertebral hemangioma. Hystological analysis confirmed the local relapse in the prostate...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28319496/the-utility-of-68ga-psma-pet-ct-in-poorly-differentiated-metastatic-prostate-cancer
#10
Mehmet Onur Demirkol, Murat Can Kiremit, Omer Acar, Burcu Ucar, Yesim Saglican
We aimed to emphasize how useful PSMA PET/CT findings can be while trying to restage prostate cancer after radical prostatectomy in the presence of low prostate-specific antigen values. A 64-year-old man with pT3b N1 M0 Gleason 7 adenocarcinoma of the prostate presented 5 years postoperatively with a palpable axillary mass, whereas his prostate-specific antigen was 0.08 ng/mL. Conventional imaging studies and histopathologic findings of the axillary mass biopsy revealed inconclusive results. Ga-PSMA PET/CT demonstrated PSMA-positive metastatic lesions, the largest one being located in the right axilla...
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288049/catecholamine-induced-chest-pain-mimicking-infarction-due-to-an-mibg-negative-and-dopa-positive-succinate-dehydrogenase-syndrome-subunit-b-related-pheochromocytoma
#11
Alberto Mazza, Alice Ferretti, Antonella Paola Sacco, Domenico Rubello, Patrick M Colletti
This 16-year-old boy presented with acute retrosternal pain possibly representing acute myocardial infarction. Cardiac enzymes were within reference ranges. There were marked increases in metanephrine to 3299 μg/24 h (reference, <400 μg/24 h), normetanephrine to 1309 μg/24 h (reference, 0-390 μg/24 h), and chromogranin A to 1605 ng/mL (reference, 0-150 μg/24 h). An incidental left adrenal mass was found during CTPA performed to exclude pulmonary embolism. I-MIBG scintigraphy was negative, and genetic screening detected SDHB (succinate dehydrogenase syndrome subunit B) gene mutation...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288048/quality-and-safety-in-health-care-part-xxv-general-thoracic-surgery
#12
Jay A Harolds
The General Thoracic Surgery Database of the Society of Thoracic Surgeons provides highly useful information in quality and safety in general thoracic surgery, including ratings of the surgeons and institutions participating in this type of surgery. This article discusses some of the work based on General Thoracic Surgery Database information regarding surgery for lung cancer and esophageal cancer.
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288047/bertolotti-syndrome-demonstrated-on-18f-naf-pet-ct
#13
Sharjeel Usmani, Najeeb Ahmed, Fahad Marafi, Fareeda Al Kandari
Bertolotti syndrome is a form of low-back pain associated with lumbosacral transitional vertebrae. We report a case of a 34-year-old woman with breast cancer presented with severe low-back pain. F-NaF PET/CT demonstrates increased radiotracer uptake at the transverse-sacral articulation corresponding to hemisacralized left transverse process of L5 vertebra. Increased tracer uptake in patients with lumbosacral transitional vertebrae seems to correlate with lower-back pain symptoms. F-NaF PET/CT can be useful in evaluation of some uncommon causes of low-back pain...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288046/fdg-pet-ct-in-pediatric-neurolymphomatosis
#14
Carole de Vaugelade, Henri de Clermont-Gallerande, Marie Meyer, Aude My Duyen Tiphaine, Alice Benjamin, Stephane Ducassou, Jean-François Chateil, Philippe Fernandez
An 8-year-old girl presented with back and leg pain and left arm and leg paresis. Lumbar puncture was suggestive of lymphocytic meningitis without identified organism. A second lumbar puncture demonstrated a large number of lymphoid B cells, with positive immunohistochemical staining for CD20 and CD25, proving the diagnosis of neurolymphomatosis. Brain and spine MRI demonstrated involvement of cervical and lumbosacral nerve roots. FDG PET/CT showed multiple bone metastases in addition to nerve involvement. Postchemotherapy FDG PET/CT demonstrated complete metabolic response...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288045/lower-extremity-pseudomyogenic-hemangioendothelioma-on-bone-scintigraphy-and-pet-ct
#15
Simone Krebs, Serena Monti, Natasha Lewis, Alessandro Luciano, Lapo Rastrelli, Lorenzo Mannelli
An otherwise healthy 33-year-old man presents with new pain involving the right leg. Radiographs of the femur showed scattered lucent lesions. An MRI of the knee demonstrated nonspecific cortical-based lesions. Biopsy confirmed pseudomyogenic hemangioendothelioma. MDP bone scan and F-FDG PET/CT were obtained to evaluate for extent of disease demonstrating disease limited to the bone of the right leg. Interestingly, the FDG and MDP uptake and CT appearance of the disease were not entirely concordant, with some lesions being lytic on CT and associated with FDG and MDP uptake, other lesions being CT silent and either MDP or FDG avid...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288044/the-accessory-sacroiliac-joint-diagnosed-with-bone-spect-ct
#16
Ji-Hun Kang, Min-Woo Kim, Eun Ha Moon, Young Jun Kim, Ki Pi Yu
The accessory sacroiliac (SI) joint is not rare and can be one of the causes of lower back pain. We present a case of a 35-year-old woman with chronic lower back pain. Conventional radiography was equivocal, and bone scintigraphy showed a focus of mildly increased uptake in left SI joint region. SPECT/CT revealed increased uptakes in the accessory articulations between both sacral alae and iliac bones, and confirmed the diagnosis of accessory SI joint. This case illustrates the SPECT/CT findings of the accessory SI joint...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288043/prognostic-value-of-pretreatment-metabolic-tumor-volume-and-total-lesion-glycolysis-using-18f-fdg-pet-ct-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-anti-vascular-endothelial-growth-factor-targeted-agents
#17
Sang Hyun Hwang, Arthur Cho, Mijin Yun, Young Deuk Choi, Sun Young Rha, Won Jun Kang
PURPOSE: The aim of this study was to evaluate the prognostic value of pretreatment metabolic tumor volume (MTV) and total lesion glycolysis (TLG) using F-FDG PET/CT in patients with metastatic renal cell carcinoma (RCC) after treatment with anti-vascular endothelial growth factor-targeted agents. METHODS: Fifty-six patients with metastatic RCC who underwent F-FDG PET/CT for staging and recurrence evaluation were retrospectively enrolled. SUVmax, MTV, and TLG were measured using F-FDG PET/CT in all patients...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288042/metabolic-tumor-volume-and-total-lesion-glycolysis-in-oropharyngeal-cancer-treated-with-definitive-radiotherapy-which-threshold-is-the-best-predictor-of-local-control
#18
Joël Castelli, Adrien Depeursinge, Berardino de Bari, Anne Devillers, Renaud de Crevoisier, Jean Bourhis, John O Prior
PURPOSE: In the context of oropharyngeal cancer treated with definitive radiotherapy, the aim of this retrospective study was to identify the best threshold value to compute metabolic tumor volume (MTV) and/or total lesion glycolysis to predict local-regional control (LRC) and disease-free survival. METHODS: One hundred twenty patients with a locally advanced oropharyngeal cancer from 2 different institutions treated with definitive radiotherapy underwent FDG PET/CT before treatment...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288041/lymph-node-activation-by-pet-ct-following-vaccination-with-licensed-vaccines-for-human-papillomaviruses
#19
Emily E Coates, Pamela J Costner, Martha C Nason, Douglas M Herrin, Shielah Conant, Peter Herscovitch, Uzma N Sarwar, Lasonji Holman, Jillian Mitchell, Galina Yamshchikov, Richard A Koup, Barney S Graham, Corina M Millo, Julie E Ledgerwood
BACKGROUND: While PET using F-FDG is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on F-FDG PET scans. The pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. Furthermore, the addition of adjuvants to vaccines can further enhance the immune response. The presented study was designed to define lymph node activation following administration of the Food and Drug Administration-licensed human papillomavirus vaccines, Cervarix and Gardasil, which contain similar antigens with different adjuvants...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28288040/incidentally-detected-penile-metastases-in-a-patient-of-carcinoma-urinary-bladder-on-follow-up-fdg-pet-ct
#20
Girish Kumar Parida, Sarthak Tripathy, Shambo Guha Roy, Abhinav Singhal, Chandanjyoti Das, Shamim Ahmed Shamim
Penis is an extremely uncommon site for metastases to occur and is often associated with very grave prognosis. Most of the secondary tumors originating in the penis have primaries from prostate, urinary bladder, and gastrointestinal tract. We hereby report a 65-year-old man, known case of carcinoma urinary bladder, who came for FDG PET/CT for metastatic workup. PET/CT study revealed FDG-avid mass lesion in the root and shaft of the penis, making it suggestive of metastases, which was confirmed later by MRI correlation...
March 10, 2017: Clinical Nuclear Medicine
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