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Clinical Nuclear Medicine

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https://www.readbyqxmd.com/read/28525463/fdg-pet-ct-as-a-new-method-for-diagnosis-and-whole-body-evaluation-of-lemierre-syndrome
#1
Jordy P Pijl, Andor W J M Glaudemans, Riemer H J A Slart, Thomas C Kwee
Lemierre syndrome is a rare disease that is defined by a pharyngeal infection, complicated by septicemia and internal jugular vein thrombosis followed by septic emboli. Because of its rarity, a delay in diagnosis is not uncommon. However, given the mortality rate of approximately 2%, prompt diagnosis and detection of septic emboli are essential to initiate prompt treatment, preventing organ damage and ongoing sepsis. We present 3 cases that demonstrate the value of FDG-PET/CT as a possible alternative or adjunct to conventional imaging methods for diagnosis and whole-body evaluation of Lemierre syndrome...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525462/increased-18f-2-fluorodeoxysorbitol-18f-fds-activity-in-a-pituitary-spindle-cell-carcinoma-reply
#2
Xin Cheng, Wenjia Zhu, Ruixue Cui
No abstract text is available yet for this article.
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525461/18f-fdg-pet-ct-of-papillary-carcinoma-in-a-lateral-thyroglossal-duct-cyst
#3
Christos Sachpekidis, Matthias S Dettmer, Sabine Weidner, Roland Giger, Jan Wartenberg
A 69-year-old man presented with bulging of the right oropharyngeal wall, which revealed cytopathologically malignant cells. The man underwent MRI and F-FDG PET/CT, which demonstrated a cystic parapharyngeal lesion with an F-FDG-avid soft tissue component and right cervical lymph node. The patient was operated on and showed thyroid cancer in normal thyroid tissue, compatible with a papillary thyroid carcinoma in a lateral thyroglossal duct cyst and 2 ipsilateral lymph node metastases. Despite its rarity, papillary thyroid carcinoma in a thyroglossal duct cyst should be kept as one of the differential diagnoses in patients presenting with parapharyngeal cystic lesion...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525460/coexistent-superscan-and-lincoln-sign-on-bone-scintigraphy
#4
Mukta Kulkarni, Atul Soni, Shubhangi Shetkar, Momin Amer, Amruta Mulavekar, Prathamesh Joshi
A 70-year-old man underwent Tc-methylene diphosphonate scintigraphy for staging of adenocarcinoma prostate. Scintigraphy revealed diffuse increased tracer uptake in skeletal system along with faint renal visualization, a pattern compatible with metastatic superscan. The scintigraphy also revealed increased radiotracer uptake in the body of the mandible-Lincoln sign or black beard sign. Radiological imaging revealed sclerotic lesions throughout the skeleton including the mandible, confirming widespread skeletal metastases...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525459/the-impact-of-a-bayesian-penalized-likelihood-reconstruction-algorithm-on-the-evaluation-of-indeterminate-pulmonary-nodules-by-dual-time-point-18f-fdg-pet-ct
#5
Tiago Sampaio Vieira, Diogo Borges Faria, Fernando Azevedo Silva, Francisco Pimentel, José Pereira de Oliveira
We present the case of a patient with history of colon cancer, referred for the evaluation of indeterminate pulmonary nodules by F-FDG PET/CT. A dual-time point protocol was performed, and images were reconstructed using VUE Point HD and a Bayesian-penalized likelihood reconstruction algorithm (Q.Clear). Visually, the quality of the images was considered better when Q.Clear was used with β value of 200, uptake in the smallest nodule (7 mm) was clearly visible only with Q.Clear reconstruction, and uptake in the smaller nodules was best defined in the delayed time point acquisition...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525458/unusual-presentation-of-relapse-in-neuroblastoma-pancreatic-metastases-detected-by-123i-mibg-scintigraphy
#6
Maria Felicia Villani, Maria Luisa D'Andrea, Aurora Castellano, Milena Pizzoferro, Maria Carmen Garganese
Neuroblastoma is the most common extracranial solid tumor in children and accounts for 8% to 10% of all childhood cancers. The spread of metastases is both lymphatic and hematogenous. Hematogenous route occurs most commonly in bone marrow and cortical bone; pancreatic metastases are very rare, and there are few reports about this topic in medical literature. We report the case of a 14-year-old boy who suffers a third relapse of neuroblastoma: in this patient I-MIBG confirms that lesions detected by CT were due to a relapse in pancreatic tissue and influenced subsequent therapeutic management...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525457/stensen-duct-relapse-of-diffuse-large-b-cell-lymphoma-an-unusual-pattern-detected-with-18f-fdg-pet-ct
#7
Punit Sharma, Shilpa Bhartia
F-FDG PET/CT is now an established modality for staging and restaging high-grade lymphomas, including diffuse large B-cell lymphoma. We here present the case of a 51-year-old woman successfully treated for diffuse large B-cell lymphoma. Follow-up F-FDG PET/CT demonstrated an unusual site of relapse involving left Stensen (parotid) duct, which was confirmed with cytology. By identifying such unusual sites of lymphomatous involvement, F-FDG PET/CT can have significant bearing on patient management.
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525456/incidental-thyroid-nodule-noted-on-intra-arterial-hepatic-maa-scan-before-90y-sirt
#8
Sin-Di Lee, Chin Hu, Nan-Jing Peng
We report a case of a 61-year-old man who had recurrent hepatocellular carcinoma admitted for series evaluation before Y selective internal radiotherapy (SIRT). Intra-arterial hepatic Tc macroaggregated albumin scan before Y-SIRT revealed a 2.7-cm incidental low-density thyroid nodule with hot uptake. TcO4 scan revealed corresponding hot uptake in the thyroid nodule with near background uptake of normal thyroid tissue, favored autonomous nodule. After Y-microsphere SIRT, bremstrallung imaging revealed no Y-microsphere deposition to thyroid...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525455/18f-fdg-pet-ct-of-malignant-angiomyolipoma-with-tumor-thrombus
#9
Andrew Griffin
Renal angiomyolipomas are the most common renal mesenchymal tumors. While classic angiomyolipomas are benign, there are a number of other subtypes. Epithelioid variants are potentially malignant and may be indistinguishable from renal cell carcinoma on imaging. We present a 52-year-old woman who underwent left nephrectomy for an aggressive-appearing malignant renal epithelioid angiomyolipoma. At 6 months postoperatively, restaging FDG PET/CT demonstrated a hypermetabolic left adrenal mass extending to the left adrenal vein, left renal vein, inferior vena cava, and right atrium (SUVmax = 12)...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525454/bilateral-tibial-osteofibrous-dysplasia-on-18f-fdg-pet-ct
#10
Hiroaki Nagano, Megumi Jinguji, Masanori Nakajo, Michiyo Higashi, Takashi Yoshiura
A 17-year-old girl had pain in the right front lower leg while road racing 2 months earlier. Radiography and CT showed osteolytic lesions in the medial part of the bilateral tibia. Bone scintigraphy showed focally increased radiotracer uptake in the bilateral tibia. The lesions showed hypermetabolism on FDG PET/CT. Osteofibrous dysplasia was suspected from the radiographic findings, but adamantinoma or metastases could not be excluded. Surgical biopsies were performed, and histopathologic studies confirmed the diagnosis of bilateral osteofibrous dysplasia...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525453/esophageal-cancer-diagnosed-by-thyroid-scintigraphy
#11
María de la Cinta Calvo-Morón, Francisco Javier García-Gómez, Pablo Antonio de la Riva-Pérez, Juan Castro-Montaño
We report a 34-year-old man referred because of increasing dysphagia secondary to goiter. Thyroid scintigraphy and SPECT/CT images helped to recognize an unsuspected esophageal dilation due to a poorly differentiated adenocarcinoma arising at the lower end of the esophagus. Further examinations are mandatory when abnormal activities are observed during thyroid scintigraphy.
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525452/concomitant-lung-cancer-and-gastrointestinal-stromal-tumor-first-report-of-hypoxia-imaging-with-18f-faza-pet-ct
#12
Paola Mapelli, Elena Incerti, Federico Fallanca, Valentino Bettinardi, Antonia Compierchio, Valeria Masiello, Claudio Doglioni, Francesca Rossetti, Giampiero Negri, Luigi Gianolli, Maria Picchio
A 76-year-old man underwent F-FDG PET/CT to complete staging and characterize a suspicious lung mass. Images showed intense uptake in the lung lesion and faint uptake in correspondence of a gastric mass, which was subsequently biopsied revealing a gastrointestinal stromal tumor. A F-FAZA PET/CT was also performed because of patient's enrollment in a prospective clinical trial (trial registration no. EudraCT 2011-002647-98), showing heterogeneous uptake of F-FAZA in the pulmonary lesion and faint uptake in correspondence of the gastrointestinal stromal tumor...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525451/metastases-from-colorectal-cancer-avid-on-68ga-psma-pet-ct
#13
Lise Hangaard, Mads Ryø Jochumsen, Mikkel Holm Vendelbo, Kirsten Bouchelouche
Ga-PSMA PET/CT is currently used for detection of prostate cancer including metastases, even at low prostate-specific antigen values. A grown number of reports have shown increased uptake of PSMA in neovessels of nonprostatic malignancies including lung cancer, and recently a case report has demonstrated increased PSMA uptake in colorectal adenocarcinoma. In this case report, we demonstrate increased Ga-PMSA uptake on PET/CT in metastases from previously treated colon adenocarcinoma, and it illustrates the importance of histology of suspicious lesions on Ga-PSMA PET/CT...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525450/neuroblastoma-presenting-as-non-mibg-avid-widespread-soft-tissue-metastases-without-bone-involvement-revealed-by-fdg-pet-ct-imaging
#14
Nelleke Tolboom, Sabah E Servaes, Hongming Zhuang
Soft tissue metastases from neuroblastoma very rarely occur without concurrent osseous metastases. We report 1 case of non-MIBG-avid, high-risk neuroblastoma in a pediatric patient who had widespread soft tissue metastases without concurrent osseous lesion on FDG PET/CT imaging.
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525449/spontaneous-recovery-of-rosai-dorfman-disease-on-fdg-pet-ct
#15
Qianqian Xue, Weibing Miao
Rosai-Dorfman disease is a rare systemic proliferative disorder of histiocytes, which mainly manifests as lymphadenopathy but also often involves extranodal tissues. Rosai-Dorfman disease was often self-limited. We hereby report a case of Rosai-Dorfman disease involving both the lymph nodes and the lungs, which was spontaneously resolved on FDG PET/CT.
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28525448/18f-fluorocholine-pet-ct-complementing-the-role-of-dynamic-contrast-enhanced-mri-for-providing-comprehensive-diagnostic-workup-in-prostate-cancer-patients-with-suspected-relapse-following-radical-prostatectomy
#16
Shelvin Kumar Vadi, Baljinder Singh, Rajender K Basher, Ankit Watts, Ashwani K Sood, Anupam Lal, Nandita Kakkar, S K Singh
PURPOSE: The aim of this study was to compare the diagnostic performance of F-fluorocholine (FCH) PET/CT and dynamic contrast-enhanced MRI (DCE-MRI) of pelvis in restaging prostate cancer (PC) patients with biochemical recurrence (BCR) following radical prostatectomy (RP). METHODS: Twenty PC patients who had undergone RP and had BCR were recruited in this study. All the patients underwent whole-body FCH PET/CT and DCE-MRI of the pelvis. An overall pattern of recurrent disease was analyzed, and diagnostic accuracy for the detection of pelvic disease recurrence by the 2 modalities was evaluated by taking histopathologic analysis as the criterion standard...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28489611/fdg-pet-ct-in-aortic-valve-bioprosthesis-infection
#17
Lucia Rampin, Alice Ferretti, Maria Cristina Marzola, Lolita Sasset, Sotirios Chondrogiannis, Anna Maria Cattelan, Domenico Rubello, Patrick M Colletti
A 62-year-old man presented with persistent fever, weakness, and retrosternal pain 3 years after aortic valve bioprosthesis (AVR). His white blood cell count was 11,000/μL and C-reactive protein was 13.6 mg/dL. Consecutive blood cultures isolated Staphylococcus epidermidis and capitis. Transesophageal echocardiography demonstrated small aortic valve prosthesis vegetation. F-FDG PET/CT revealed prominent AVR activity, SUVmax = 12.2. He was treated with daptomycin, meropenem, and gentamicin for 1 month and followed by daptomycin and carbapenem for 3 months...
May 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28481797/incidental-prostate-specific-membrane-antigen-uptake-in-a-peripheral-nerve-sheath-tumor
#18
Shankar Vamadevan, Ken Le, Lily Shen, Leo Ha, Robert Mansberg
A 66-year-old man with recently diagnosed prostate cancer (Gleason score 9) was referred for Ga-prostate-specific membrane antigen (PSMA) PET/CT with prostate-specific antigen level of 7.5 μg/L. PET/CT demonstrated increased PSMA uptake (SUVmax 4.7) in a soft tissue density in the left adductor compartment. MRI and cytopathology of the biopsied soft tissue density was compatible with a peripheral nerve sheath tumor. This case illustrates that PSMA uptake can occur in a peripheral nerve sheath tumor and should be taken into consideration as a benign cause of PSMA uptake...
May 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28481796/18f-sodium-fluoride-pet-ct-in-paget-disease
#19
Francesca Cucchi, Lene Simonsen, Annemette Geilager Abild-Nielsen, Rikke Broholm
Paget disease (PD) of bone is a benign but chronic disorder of bone metabolism. We report a case of an 85-year-old man with several fractures in the pelvis and radiograph raising suspicion of metastases. An F-NaF PET/CT demonstrated high F-NaF uptake in the same regions. The integrated assessment of imaging findings, supported by biochemistry, allowed diagnosing PD. The F-NaF PET/CT is a supplementary diagnostic instrument in the diagnosis of PD, and use of F-NaF PET/CT in this context, especially finalized to the differential diagnosis with metastatic lesions, requires the physician to be familiar with imaging patterns of this disease...
May 6, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28481795/the-use-of-fdg-pet-ct-imaging-for-the-assessment-of-early-antifungal-treatment-response-in-disseminated-fusariosis
#20
Romain-David Seban, Gérald Bonardel, Mohamed Guernou, David Lussato, Mathieu Queneau
Fusariosis is an opportunistic infection, caused by a filamentous fungus, found on plants and in soil. The treatment of disseminated pattern, seen in immunocompromised patients with severe neutropenia, is difficult because of antifungal therapy resistance. A 12-year-old girl, who was diagnosed with B-cell acute lymphoblastic leukemia, developed multiple widespread skin papules and subcutaneous nodules, at day 20 of consolidation therapy. Histological examination with cultures of skin tissue revealed Fusarium species...
May 6, 2017: Clinical Nuclear Medicine
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