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Clinical Nuclear Medicine

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https://www.readbyqxmd.com/read/28195901/prognostic-molecular-and-imaging-biomarkers-in-primary-glioblastoma
#1
Edit Bosnyák, Sharon K Michelhaugh, Neil V Klinger, David O Kamson, Geoffrey R Barger, Sandeep Mittal, Csaba Juhász
PURPOSE: Several molecular glioma markers (including isocitrate dehydrogenase 1 [IDH1] mutation, amplification of the epidermal growth factor receptor [EGFR], and methylation of the O6-methylguanine-DNA methyltransferase [MGMT] promoter) have been associated with glioblastoma survival. In this study, we examined the association between tumoral amino acid uptake, molecular markers, and overall survival in patients with IDH1 wild-type (primary) glioblastoma. PATIENTS AND METHODS: Twenty-one patients with newly diagnosed IDH1 wild-type glioblastomas underwent presurgical MRI and PET scanning with alpha[C-11]-L-methyl-tryptophan (AMT)...
February 14, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195914/ictal-pet-in-ohtahara-syndrome-with-hemimegalencephaly
#2
Shambo Guha Roy, Madhavi Tripathi, Manjari Tripathi, Bhargavi Ramanujam, Abhinav Singhal, Chandrasekhar Bal
Ohtahara syndrome is one of the causes of infantile epilepsies, which presents with refractory seizures and characteristic EEG changes. It is often associated with structural anomalies in the brain. We report a case of 5-month-old girl with Ohtahara syndrome with hemimegalencephaly who presented with refractory seizures and ictal FDG PET/CT helped in localizing the seizure focus.
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195913/glucose-hypometabolism-in-developmental-venous-anomaly-without-apparent-parenchymal-damage
#3
Masamichi Imai, Mika Tanaka, Kenji Ishibashi, Aya Tokumaru, Kenji Ishii
Two cases of F-FDG PET in developmental venous anomaly (DVA) with visual impairment were examined. Plain MRI could not determine the cause of visual symptoms; a contrast-enhanced CT scan showed the existence of DVA without apparent parenchymal damage due to infarction or hemorrhage. F-FDG PET revealed that the hypometabolic area extended to the visual tract, thus explaining the association between the visual impairment and DVA. F-FDG PET is therefore a useful tool for the evaluation of symptomatic DVA.
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195912/visualization-of-posttraumatic-splenosis-on-chemokine-receptor-cxcr4-targeted-pet-ct
#4
Thorsten Derlin, Hans-Jürgen Wester, Frank M Bengel, Katja Hueper
The C-X-C motif chemokine receptor 4 (CXCR4) is expressed by a variety of inflammatory and malignant cells. We report the case of a 54-year-old woman with recurrent urinary tract infection who underwent a Ga-pentixafor PET/CT for detection of occult infectious foci. As a secondary finding, multiple CXCR4 abdominal lesions could be seen, consistent with the diagnosis of long-known posttraumatic splenosis. It is important to be aware that CXCR4-directed imaging may identify splenic tissue based on the presence of inflammatory cells and that both benign and malignant cells may show CXCR4 expression to avoid misinterpretation...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195911/a-restless-leg-syndrome-incidentally-detected-by-an-18f-fdg-positron-emission-tomography
#5
Jessica Ohnona, Arnaud Metlaine, Damien Leger, Jean-Noël Talbot
A case of a restless leg syndrome (RLS) was incidentally detected in a 49-year-old woman referred for an F-FDG PET/CT in monitoring her breast cancer. She was treated with chemotherapy and on long-term hormone therapy. Diffuse F-FDG uptake of calf muscles was visualized. Medical history revealed that the patient felt leg cramps in supine position, suggesting RLS. The diagnosis was confirmed using clinical rating scales and polysomnography. RLS being underdiagnosed, this type of FDG PET/CT incidental finding should prompt to check the presence of evocative symptoms and refer the patient to a physician specialized in sleep disorders...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195910/quality-and-safety-in-health-care-part-xxiii-bypass-leg-surgery
#6
Jay A Harolds
The efforts of the Vascular Quality Initiative of the Society for Vascular Surgery and its regional groups, including the Vascular Study Group of New England, have been very helpful in furthering medical knowledge in multiple areas of vascular surgery and hopefully in improving quality and safety. One of the areas focused on has been leg bypass surgery. The American College of Surgeons National Surgical Quality Improvement Program has also provided information relevant to leg bypass surgery quality improvement, but there are differences between this program and that from the Vascular Quality Initiative...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195909/capillary-hemangioma-of-thoracic-spinal-cord-pet-ct-and-mr-findings
#7
Guohua Shen, Minggang Su, Junyi Zhao, Bin Liu, Anren Kuang
Capillary hemangiomas are frequently encountered superficially in the cutaneous, subcutaneous, or mucosal tissues during the childhood and early adulthood, but the occurrence of spinal intradural capillary hemangioma is relatively rare. Herein, we report a case with capillary hemangioma of the thoracic spine. MR and PET/CT features of this lesion are presented, and awareness of this entity may help differentiate it from other spinal intradural tumors.
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195908/quality-and-safety-in-health-care-part-xxiv-more-on-vascular-surgery
#8
Jay A Harolds
The use of registries such as the Vascular Quality Initiative and its regional groups, such as the Vascular Study Group of New England, have been very helpful in investigating problems related to quality and safety in vascular surgery. This article discusses some of their contributions regarding carotid artery procedures, the use of certain medications in the perioperative period, and the risk factors for sustaining a major cardiac complication while in the hospital after vascular surgery.
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195907/solitary-psma-positive-pulmonary-metastasis-in-biochemical-relapse-of-prostate-cancer
#9
Nils Groe Hokamp, Carsten Kobe, Eric Linzenich, David Maintz, Alexander Drzezga
A 63-year-old man with a history of prostate cancer, treated with resection, radiation, and androgen-depriving therapy over 4 years, was referred to our department with suspicion of recurrence based on increased blood PSA levels (1.60 ng/mL). Ga PSMA PET/CT identified a solitary, PSMA-positive pulmonary nodule in the right lung. After resection, histologic analysis confirmed prostatic origin, and the blood PSA level decreased to 0.13 ng/mL. Solitary pulmonary metastasis from prostate cancer is rare. The benefits of local treatment of a single metastasis even in advanced disease are disputed among oncologists...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195906/prominent-pulmonary-metastases-without-concurrent-osseous-involvement-in-patients-with-high-risk-neuroblastoma
#10
Xia Bai, Hongming Zhuang
Metastases from high-risk neuroblastomas generally are to the bone or bone marrow. Multiple lung metastases are rare, especially when there was no concurrent osseous metastasis. We report 2 cases of high-risk neuroblastomas having prominent lung metastases without concurrent osseous lesion observed.
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195905/value-of-intratumoral-metabolic-heterogeneity-and-quantitative-18f-fdg-pet-ct-parameters-to-predict-prognosis-in-patients-with-hpv-positive-primary-oropharyngeal-squamous-cell-carcinoma
#11
Esther Mena, Mehdi Taghipour, Sara Sheikhbahaei, Abhinav K Jha, Arman Rahmim, Lilja Solnes, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). PATIENTS AND METHODS: We retrospectively investigated 105 patients with HPV-positive OPSCC. SUVmax and metabolic tumor volume (MTV) were measured for the primary tumors and when available for the metastatic sites. Primary tumor intratumoral metabolic heterogeneity was calculated as the area under a cumulative SUV volume histograms curve (AUC-CSH)...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195904/pericardial-synovial-sarcoma-followed-up-with-contrast-enhanced-pet-ct
#12
Avani S Jain, Shelley Simon, Indirani Muthukrishnan, Aashish Gambhir, Sushma Patil
Pericardial synovial sarcoma is an extremely rare tumor, and a challenging diagnosis due to nonspecific diverse presentation requiring a very strong clinical acumen along with an aggressive multimodal approach. Histopathological confirmation remains the gold standard. The optimal management is unclear because of very few cases reported in literature. Herein, we describe the findings on contrast-enhanced FDG PET-CT facilitating the staging, lesion characterization, and timely response assessment to chemotherapy...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195903/muscle-involvement-of-multiple-myeloma-revealed-by-fdg-pet-ct
#13
Meng Liang, Minggang Su, Rang Wang, Weiya Wang, Chengzhong Fan
Extramedullary myeloma can occur in variety of organs; however, muscle involvement is rarely reported. Here we present a case of a multiple myeloma patient with muscle involvement found by F-FDG PET/CT, which is sensitive in detecting extramedullary lesions of multiple myeloma. Plasmacytoma was confirmed by pathological biopsy afterwards.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195902/mibg-localization-of-a-subclinical-paraganglioma-of-the-bladder
#14
Ayman Mithqal, Pasha Darvishi, Patrice Rehm
Urinary bladder paragangliomas are very rare, and the majority are hormonally active. Nonfunctioning paragangliomas are even rarer and more difficult to diagnose because of absence of catecholamine secretion. We present a 27-year-old woman with an asymptomatic paraganglioma of the urinary bladder discovered incidentally in a patient with prior resection of a functional pararenal paraganglioma. Metabolic profiles and cystoscopy were nondiagnostic. We demonstrate the increased sensitivity of I-MIBG SPECT/CT compared with planar scintigraphy for detection of a nonfunctional paraganglioma of the urinary bladder, which makes it valuable in evaluation of functional and nonfunctional paragangliomas...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28166141/fdg-pet-ct-findings-of-primary-hepatic-leiomyosarcoma-in-an-immunocompetent-pediatric-patient
#15
Peng Xie, Hongming Zhuang
Primary hepatic leiomyosarcoma generally occurs only in adult patients or pediatric patients with immunodeficiency. We report here the FDG PET/CT findings of primary hepatic leiomyosarcoma in a 10-year-old immunocompetent girl.
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28166159/fdg-pet-ct-assesses-the-risk-of-femoral-pathological-fractures-in-patients-with-metastatic-breast-cancer
#16
Gary A Ulaner, Alexandra M Zindman, Junting Zheng, Tae Won B Kim, John H Healey
PURPOSE: Assessment of pathological fracture risk is critical to optimize the use of prophylactic orthopedic fixation to prevent pathological fractures. Better prediction of pathological fracture risk is needed. We evaluated if quantitative measures of FDG avidity can assess femoral pathological fracture risk in patients with metastatic breast cancer (MBC). PATIENTS AND METHODS: A Health Insurance Portability and Accountability Act-compliant retrospective case-control study was performed under institutional review board waiver...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28166158/interrupted-131i-procedures-for-patients-with-differentiated-thyroid-cancer-comparing-thyroxine-withdrawal-with-recombinant-thyrotropin-preparation-techniques
#17
Shawn Karls, Gad Abikhzer, Michael Tamilia, Stephan Probst
OBJECTIVE: In patients with differentiated thyroid carcinoma scheduled to receive doses of I for diagnostic or therapeutic purposes, we compared patients prepared with thyroid hormone withdrawal (THW) versus recombinant human thyroid stimulating hormone (rh-TSH) to evaluate the incidence of cancelled procedures because of inadequate thyroid stimulation. METHODS: Thyroid cancer patients after thyroidectomy who were scheduled for diagnostic or therapeutic I procedures between January 2012 and June 2015 were retrospectively reviewed...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28166157/223ra-dichloride-bone-targeted-therapy-in-a-case-of-metastatic-salivary-duct-carcinoma
#18
Matteo Manfredi, Mario Airoldi, Marcello Tucci, Consuelo Buttigliero, Antonella Parente, Tiziana Angusti
Salivary duct carcinoma (SDC) is a rare malignancy, frequently overexpressing androgen receptor (AR). Therefore, similar to AR-positive prostate cancer (PCa), AR-positive SDC patients benefit from androgen deprivation therapy and, after progression on ADT, might take advantage of Ra dichloride, a radiopharmaceutical approved for the treatment of castration-resistant PCa with symptomatic bone disease. We report the case of a 75-year-old man with castration-resistant SDC and osteoblastic bone metastases who, after Ra treatment, achieved adequate control of bone pain and bone lesion reduction with minor side effects...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28166156/incidental-99mtc-dtpa-uptake-in-tarlov-cysts-on-radionuclide-spect-ct-cisternography
#19
Shankar Vamadevan, Ken Le, Chuong Bui, Robert Mansberg
Sacral perineural cysts are also known as Tarlov cysts. A 58-year-old man with suspected intracranial hypotension was evaluated with Tc-DTPA radionuclide cisternography. Radionuclide planar and SPECT/CT cisternography revealed Tc-DTPA uptake in sacral lesions. Spine MRI confirmed Tarlov cysts at the S1 and S2 levels.
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28166155/multifocal-osteosarcoma-unusual-presentation-and-imaging-findings
#20
Somali Gavane, Anita P Price, Heather Magnan, Sonia Mahajan, Neeta Pandit-Taskar
Multifocal osteosarcoma is usually defined as the occurrence of a tumor at 2 or more sites in a patient without pulmonary metastases and may be synchronous with more than one lesion seen at presentation or metachronous with new tumors developing after the initial treatment. It is difficult to determine whether these represent synchronous multiple primary lesions or metastases. We present a rare case of widespread synchronous multifocal osteosarcoma and a brief review of the literature.
February 3, 2017: Clinical Nuclear Medicine
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