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Clinical Neurology and Neurosurgery

Dong-Dong Xiao, Peng-Fei Yan, Yu-Xuan Wang, Mohamed Saied Osman, Hong-Yang Zhao
OBJECTIVES: To investigate the diagnostic value of magnetic resonance imaging (MRI)-based 3D texture and shape features in the differentiation of glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL). PATIENTS AND METHODS: A total of eighty-two patients, including sixty patients with GBM and twenty-two patients with PCNSL were followed up retrospectively from January 2012 to September 2017. MRI-based 3D texture and shape analysis were performed to evaluate the detectable differences between the two malignancies...
August 2, 2018: Clinical Neurology and Neurosurgery
Sina Abdollahzade, Sara Hanaei, Maryam Sadr, Mohammad Hossein Mirbolouk, Ehsan Fattahi, Nima Rezaei, Alireza Khoshnevisan
OBJECTIVES: As the important role of inflammation in pathophysiology of intervertebral disc degeneration and inconsistency regarding the role of pro-inflammatory cytokine genes SNPs, the current case-control study was designed to assess this in Iranian population. PATIENTS AND METHODS: The genomic DNA of peripheral leukocytes of 76 patients and 140 healthy controls were investigated to sequence 9 SNPs of pro-inflammatory cytokine genes of interleukin 1 (IL-1), interleukin 6 (IL-6), and Tumor Necrosis Factor α (TNF-α) family...
August 2, 2018: Clinical Neurology and Neurosurgery
Bernardo Cacho-Díaz, Héctor Spínola-Maroño, Victor A Arrieta, Martin Granados-García, Talia Wegman-Ostrosky, Laura G Mendoza-Olivas, Mariana Chávez-MacGregor
OBJECTIVES: Breast cancer (BC) is the leading cause of morbidity and mortality. Neurological symptoms are highly feared because they are associated with central nervous system metastases (CNSm). So, we aimed to analyze the association of neurological symptoms with CNSm. PATIENTS & METHODS: Patients with BC referred for a neuro-oncological evaluation at a cancer referral center from June 2012 to December 2017 were included. Demographic, oncological history, comorbidities, clinical symptoms and signs, and their correlation with CNSm were prospectively acquired during consultation in a computerized database...
August 2, 2018: Clinical Neurology and Neurosurgery
Oguz Baran, Mehmet Yigit Akgun, Rahsan Kemerdere, Eren Fatma Akcil, Taner Tanriverdi
OBJECTIVE: To report long-term clinical and seizure outcomes of patients who were operated upon insular gliomas via trans-opercular approach. PATIENTS AND METHODS: Since 2010, surgical resection of insular gliomas was performed via trans-opercular approach by our group. Clinical, surgical and follow-up results were analyzed retrospectively. RESULTS: The majority were low-grade (81.8%) and among them oligodendroglioma was the most common (n = 8)...
August 2, 2018: Clinical Neurology and Neurosurgery
Heui Seung Lee, Jeong Hoon Kim, Young-Hoon Kim, Seungjoo Lee
OBJECTIVE: Though outcome of brain abscess has been improved due to stereotactic drainage and appropriate antibiotic treatment, late unprovoked seizure often occurs after the abscess is resolved. The purpose of this study is to reveal the factors related to the late unprovoked seizure and effect of steroid on the prevention of seizure. PATIENTS AND METHODS: From January 2002 to August 2016, 119 patients with supratentorial brain abscesses were retrospectively analyzed...
August 1, 2018: Clinical Neurology and Neurosurgery
Xi Chen, Qing-Shuang Zhou, Liang Xu, Zhong-Hui Chen, Ze-Zhang Zhu, Song Li, Yong Qiu, Xu Sun
OBJECTIVE: To investigate the segmental instability of degenerative lumbar spondylolisthesis (DLS) with a kyphotic configuration at the involved segment, and to determine the most useful diagnostic modalities in the evaluation of instability. PATIENTS AND METHODS: This study reviewed a consecutive series of patients with L4/5 DLS between July 2010 and May 2016. The enrolled patients were divided into two groups based on preoperative neutral radiographs: the kyphotic group (Group K) and non-kyphotic group (Group NK)...
July 30, 2018: Clinical Neurology and Neurosurgery
Li-Na Zhao, Yi Liang, Xue-Jun Fang, Xiao-Man Liu, Qi-Long Jiang, Shuang-Shuang Wang, Shi-Feng She, Min Cao
OBJECTIVE: A retrospective observational cohort study was conducted to evaluate the efficacy and safety of tacrolimus in Osserman grade III and Osserman grade IV myasthenia gravis (MG) patients. PATIENTS AND METHODS: MG patients admitted to the First Affiliated Hospital of Guangzhou University of Chinese Medicine between June 2011 and January 2017 with grade III and grade IV according to the modified Osserman scale were recruited and received a telephone follow-up in September 2017...
July 30, 2018: Clinical Neurology and Neurosurgery
Jiayue Ding, Da Zhou, Shuling Shang, Liqun Pan, Jingyuan Ya, Yuchuan Ding, Xunming Ji, Ran Meng
OBJECTIVES: This retrospective study aimed to explore the impact of seasonal variations on the first ischemic events in patients with moyamoya disease (MMD). PATIENTS AND METHODS: Based on the first-time ischemic event occurrence, 113 patients, including 84 with cerebral infarction and 29 with transient ischemic attack, who were diagnosed with ischemic MMD were divided into four groups: spring (March-May), summer (June-August), autumn (September-November) and winter (December-February)...
July 30, 2018: Clinical Neurology and Neurosurgery
Ayako Nishimura, Ryotaro Ikeguchi, Masaki Kobayashi, Megumi Takeuchi, Yuko Shimizu, Hideto Saigusa, Kazuo Kitagawa
No abstract text is available yet for this article.
July 26, 2018: Clinical Neurology and Neurosurgery
Kai-Uwe Lewandrowski
OBJECTIVE: To analyze the positive predictive value of diagnostic 1% lidocaine containing transforaminal epidural steroid injections (TESI) for successful outcome after outpatient endoscopic decompression for lumbar foraminal and lateral recess stenosis. PATIENTS AND METHODS: A retrospective study of 1839 consecutive patients with an average mean follow-up of 33 months that underwent endoscopic transforaminal decompression at 2076 lumbar levels was conducted. The sensitivity, specificity, and positive predictive value of lidocaine containing diagnostic TESI at the intended surgical level were calculated based on the recorded frequency of >50% VAS score reduction, intraoperatively visualized stenosis, and clinical outcomes assessed by Macnab criteria and VAS reduction...
July 24, 2018: Clinical Neurology and Neurosurgery
Tomoko Iida, Yusuke Tomogane, Toshinori Takagi, Yuki Miyaji, Daisuke Sakamoto, Yasunori Yoshida, Reiichi Ishikura, Kumiko Ando, Nami Nakagomi, Seiichi Hirota, Shinichi Yoshimura
OBJECTIVE: Changes in brain tissue can be detected sensitively using PRESTO (principles of echo-shifting with a train of observations) magnetic resonance imaging (MRI). The aim of this study was to evaluate the correlation between the proliferative ability of astrocytoma and intratumoral spotty signal voids seen as hypo-intense dots on PRESTO MRI. PATIENTS AND METHODS: Fifty-seven astrocytic tumors, comprising 14 astrocytomas, 12 anaplastic astrocytomas, and 31 glioblastomas, were included in this retrospective study...
July 23, 2018: Clinical Neurology and Neurosurgery
Christian Wetzel, Lukas Goertz, André Pascal Schulte, Roland Goldbrunner, Boris Krischek
OBJECTIVE: Overdrainage and frequent reprogramming are common issues with programmable valves after ventriculoperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (iNPH). Flow-regulated valves may address these limitations, but data on their efficacy are sparse. We present our single-center experience with flow-regulated valves focusing on overdrainage and efficiency. PATIENTS AND METHODS: Thirty-two patients with iNPH treated with the Integra® NPH Low Flow Valve were prospectively enrolled...
July 23, 2018: Clinical Neurology and Neurosurgery
Karl-Michael Schebesch, Alexander Brawanski, Christian Doenitz, Katharina Rosengarth, Martin Proescholdt, Markus J Riemenschneider, Jirka Grosse, Dirk Hellwig, Julius Höhne
OBJECTIVES: We report on five patients with gadolinium-negative (non-enhancing magnetic resonance imaging-MRI) but 18 F-fluoroethyl tyrosine positron-emission tomography (FET-PET) positive glioma (NEG) undergoing surgery under fluorescence-guidance with fluorescein sodium 10% (FL, Alkon, Germany) in combination with a dedicated light filter (YELLOW 560 nm, Carl Zeiss Meditec, Germany). PATIENTS AND METHOD: Since 2017, five patients (3 female, 2 male; mean age 45...
July 20, 2018: Clinical Neurology and Neurosurgery
Meric A Altinoz, Josephine Nalbantoglu, Aysel Ozpinar, M Emin Ozcan, Rolando F Del Maestro, Ilhan Elmaci
OBJECTIVE: Glial tumor growth may accelerate during gestation, but epidemiological studies consistently demonstrated that parousity reduces life long risk of glial tumors. Pregnancy may also accelerate growth of medulloblastoma and meningioma, but parousity does not confer protection against these tumors. We were the first to show that medroxyprogesterone acetate (MPA) reduces rat C6 glioma growth in vitro. Now we aimed to determine the effects of MPA on human brain cancers (particularly glioblastoma) in vitro and C6 glioma in vivo...
July 19, 2018: Clinical Neurology and Neurosurgery
Marvin Darkwah Oppong, Vanessa Skowronek, Daniela Pierscianek, Oliver Gembruch, Annika Herten, Dino Vitali Saban, Philipp Dammann, Michael Forsting, Ulrich Sure, Ramazan Jabbarli
OBJECTIVES: Intracerebral hematoma (ICH) complicates the course of aneurysmal subarachnoid hemorrhage (SAH). To date, there are no unique guidelines for management of aneurysmal ICH. The aim of this study was to identify risk factors for and impact of aneurysmal ICH with special attention on treatment decisions derived from ICH volume. PATIENTS AND METHODS: All patients admitted with aneurysmal SAH between 2003 and 2016 were eligible for this study. Various demographic, clinical and radiographic characteristics of patients were correlated with the occurrence and volume of ICH in univariate and multivariate manner...
July 19, 2018: Clinical Neurology and Neurosurgery
Cezary Grochowski, Elżbieta Radzikowska, Ryszard Maciejewski
Adult mammalian neural stem cells are unique because of their properties, such as differentiation capacity, self-renewal, quiescence, and also because they exist in specific niches, which are the subventricular zone (SVZ) and subgranular zone (SGZ) - the dentate gyrus of the hippocampus. SVZ is situated along the ependymal cell layer, dividing the ventricular area and subventricular zone. There are several sources of neural stem cells such as human embryonic stem cells, human fetal brain-derived neural stem/progenitor cells, human induced pluripotent stem cells, direct reprogrammed astrocytes...
July 18, 2018: Clinical Neurology and Neurosurgery
Yu Kono, Kenya Nishioka, Yuanzhe Li, Yo Komatuzaki, Yuta Ito, Hiroyo Yoshino, Ryota Tanaka, Yasuyuki Iguchi, Nobutaka Hattori
The term cerebral small vessel disease (SVD) refers to a group of pathological processes with various etiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. SVD occurs in approximately 5% of patients. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL),a recessive form of heritable SVD, is caused by a mutation in the high temperature requirement A serine peptidase (HTRA1) gene. Recently, heterozygous mutations in HTRA1 were identified in patients with symptomatic SVD...
July 18, 2018: Clinical Neurology and Neurosurgery
Shunya Nakane, Koji Fujita, Shingo Azuma, Ryo Urushihara, Masaki Kamada, Masafumi Harada, Yuishin Izumi, Ryuji Kaji
OBJECTIVES: The establishment of biomarkers for amyotrophic lateral sclerosis (ALS) will be useful for early diagnosis and may provide evidence about pathogenesis. To elucidate whether high-field magnetic resonance (MR) findings and multimodal analysis of cerebrospinal fluid (CSF) levels of cystatin C could be indicators of upper motor neuron (UMN) involvement in ALS. PATIENTS AND METHODS: Patients with ALS (n = 20), multiple sclerosis (n = 15), immune mediated chronic polyneuropathy (n = 17), and acute polyneuropathy (n = 12) were included in this retrospective study...
July 10, 2018: Clinical Neurology and Neurosurgery
Masashi Miyazaki, Toshinobu Ishihara, Shozo Kanezaki, Naoki Notani, Tetsutaro Abe, Hiroshi Tsumura
OBJECTIVE: We aimed to investigate the relative preoperative position of the spinal cord in AIS and explore the potential risk of spinal cord injury from placement of pedicle screws. PATIENTS AND METHODS: Twenty-seven patients with a mean age of 15 ± 1.8 years (range, 12-19 years) classified as having Lenke type 1 AIS (1A: 15 cases, 1B: 8 cases, 1C: 4 cases) were analyzed. The mean Cobb angle of the main curve was 55.9 ± 14.4°. Axial CT myelography images were selected from the T4 to T12 vertebrae, and 243 images were analyzed...
July 10, 2018: Clinical Neurology and Neurosurgery
Bianka Heiling, Albrecht Waschke, Mihai Ceanga, Alexander Grimm, Otto W Witte, Hubertus Axer
We present a case of a patient with acute wrist drop caused by radial nerve torsion. NCS showed axonal lesion of the radial nerve. High-resolution ultrasound was able to visualize a constriction of the radial nerve. Nerve torsion is a rare differential diagnosis to Saturday night palsy. The patient was subjected to early surgical intervention and showed a favorable outcome in follow-up. Thus, high-resolution ultrasound may subject these patients early to surgical therapy.
July 9, 2018: Clinical Neurology and Neurosurgery
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