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Clinical Neurology and Neurosurgery

Shu-Tao Gao, Tao Xu, Chuan-Hui Xun, Wei-Dong Liang, Rui Cao, Cao Mao, Wei-Bin Sheng
OBJECTIVES: To assess and synthesize the current evidence on the association of interleukin-6 (IL-6)-572 G/C, IL-6-597 G/A, and IL-6-174 G/C polymorphisms and risk of lumbar degenerative disease (LDD). PATIENTS AND METHODS: Five electronic databases including PubMed, EMBASE, Web of Science, CNKI and Wanfang were systematically searched for potential studies previous to August 10, 2018. Summary odds ratio (OR) and corresponding 95% confidence interval (95%CI) were calculated to evaluate the association...
October 9, 2018: Clinical Neurology and Neurosurgery
Milani Deb-Chatterji, Laura Schäfer, Ulrich Grzyska, Mathias Gelderblom
No abstract text is available yet for this article.
October 3, 2018: Clinical Neurology and Neurosurgery
Matthew Roberts, Tessa Northmore, Joanne Shires, Peter Taylor, Caroline Hayhurst
OBJECTIVES: The majority of patients with supratentorial diffuse grade II glioma present with seizures, which adversely affect quality of life. The exact mechanism of epileptogenesis is unknown and the influence of tumour characteristics, radiological and histological, are not well studied, particularly following the introduction of molecular genetics in the 2016 WHO reclassification of gliomas. We sought to define predictors of seizure development and outcome in low grade glioma. PATIENTS AND METHODS: A retrospective review of patients who underwent resection of a supratentorial grade II glioma in a single institution...
October 2, 2018: Clinical Neurology and Neurosurgery
Efthimios Dardiotis, Zisis Tsouris, Alexios-Fotios A Mentis, Vasileios Siokas, Amalia Michalopoulou, Maria Sokratous, Metaxia Dastamani, Dimitrios P Bogdanos, Georgia Deretzi, Jannis Kountouras
The exact etiology of Parkinson's disease (PD) remains unclear. Some evidence supports Helicobacter pylori infection as a trigger or driving event, but detection and eradication of H. pylori are not part of PD management. The aims of this case-control study and meta-analysis were to determine (i) the prevalence of H. pylori infection in PD patients, (ii) associations between H. pylori infection and clinical status, and (iii) differences in motor status in PD patients before and after H. pylori eradication. A literature search was performed using the PubMed database...
October 1, 2018: Clinical Neurology and Neurosurgery
Kali Xu, Kay T Khine, Yinn Cher Ooi, Carolyn S Quinsey
Extraneural metastasis (ENM) of primary central nervous system (CNS) tumors is an uncommon occurrence. Case reports and case series describe ENM after shunting, but this phenomenon has not been well characterized. In this review we aim to better understand the risk factors and clinical implications of ENM associated with shunting. A literature search of cases of ENM related to shunt placement in patients with primary CNS tumors reported through January 2018 was performed using PubMed and Google Scholar. We identified 106 cases of ENM of primary CNS tumors related to shunt placement...
September 27, 2018: Clinical Neurology and Neurosurgery
Michał Tymowski, Wojciech Kaspera, Joanna Metta-Pieszka, Łukasz Zarudzki, Piotr Ładziński
OBJECTIVE: The aim of the study was to establish the usefulness of various neuropsychological tests in patients undergoing surgery due to low-grade glioma (LGG) involving supplementary motor area (SMA). PATIENTS AND METHODS: 21 patients diagnosed with LGG involving the SMA underwent, before and after surgery, screening tests (Mini Mental State Examination - MMSE, Montreal Cognitive Assessment - MoCA and Frontal Assessment Battery - FAB), tests to assess language functions (Addenbrook's Cognitive Examination-III - ACE-III, phonetic fluency tests and semantic fluency tests), tests to assess memory functions (Rey's 15-word test - RAVLT and Diagnostic Test for Brain Damage by Hillers- DCS), tests to assess executive functions (Wisconsin Card Sorting Test - WCST, Ruff Figural Fluency Test - RFFT and Trail Making Test)...
September 26, 2018: Clinical Neurology and Neurosurgery
Clarice Listik, Natally Santiago, Paul Rodrigo Reis, Fabio Godinho, Kleber Duarte, Manoel Jacobsen Teixeira, Egberto Reis Barbosa, Rubens Gisbert Cury
INTRODUCTION: Thalamic ventralis intermedius deep brain stimulation (VIM-DBS) is generally effective in treating refractory tremor in Parkinson's disease (PD) and in essential tremor (ET), but some patients do not respond well due to side effects or from loss of the effect of stimulation over time. The caudal zona incerta (ZI) has emerged as a promising target in ET, and the effects of ZI-DBS on PD tremor are less studied. Here, we describe a rare situation in which both ET and PD coexist in a 72-year-old male referred for ZI-DBS due to refractory tremor...
September 26, 2018: Clinical Neurology and Neurosurgery
Marina Vasilj, Vanja Basic Kes, Nada Vrkic, Ines Vukasovic
OBJECTIVE: The objective of the research was to evaluate diagnostic and predictive value for determination of KFLC in cerebrospinal fluid (CSF) compared to the qualitative procedure of OCB determination in patients with CIS who converted to MS during a two-year period. PATIENTS AND METHODS: KFLC, total immunoglobulin G (IgG), serum albumin and CSF albumin were determined with an immunonephelometric method in 151 patients with suspected MS who were admitted to the Neurology Clinic while CSF/serum quotients (QKFLC, QIgG and QAlb) and indexes were calculated with regards to albumin (QCSF/Qserum)...
September 25, 2018: Clinical Neurology and Neurosurgery
Yu Wang, Wangfei Wang, Minyu Zhu, Jing Wang, Yang Zhou, Kelun Huang, Jianhong Wang, Honglin Teng
OBJECTIVE: To investigate the clinical characteristics and surgical outcomes of patients with cervical spondylotic myelopathy (CSM) and prior cerebral infarction (CI); to identify whether "prior CI" correlates with poor surgical outcomes. PATIENTS AND METHODS: Twenty-two patients with CSM and prior CI were retrospectively reviewed and included as the CI group while 100 CSM patients without CI were included as the control group (matched for gender, age, symptom duration and surgical approach)...
September 24, 2018: Clinical Neurology and Neurosurgery
Anderson Chun On Tsang, Kui Kai Lau, Frederick Chun Pong Tsang, Mona Man Yu Tse, Raymand Lee, Wai Man Lui
OBJECTIVES: Intracranial atherosclerosis related large vessel occlusions (ICAS-O) are challenging to diagnose and manage. The degree of intracranial carotid artery calcification may assist pre-thrombectomy diagnosis of ICAS and guide treatment strategy. The aim of the study is to determine if intracranial carotid calcification is associated with ICAS-O. PATIENTS AND METHODS: Consecutive large vessel occlusion patients who underwent thrombectomy from 2006 to 2017 were retrospectively studied...
September 24, 2018: Clinical Neurology and Neurosurgery
Yumiko Oishi, Takenori Akiyama, Katsuhiro Mizutani, Takashi Horiguchi, Nobuaki Imanishi, Kazunari Yoshida
OBJECTIVE: The venous outlet of anterior condylar arteriovenous fistulas (AC-AVFs) often empties into the anterior condylar vein (ACV). Hypoglossal nerve palsy is one of the major complications after transvenous embolization (TVE) for the AC-AVF within the hypoglossal canal. However, no studies have investigated the route of the hypoglossal nerve within the hypoglossal canal in AC-AVF. The aim of the current study is to retrospectively verify the anatomical route of the hypoglossal nerve within its canal using dynamic computed tomography angiography (CTA) in order to facilitate the safe TVE for AC-AVF...
September 24, 2018: Clinical Neurology and Neurosurgery
Barbara M Decker, Cindy D Noyes, Mary B Ramundo, Alissa A Thomas
This is a 24 year old man with profound chronic hydrocephalus found to have a cauda equina abscess composed of Candida albicans. Prior literature reveals a paucity of central nervous system candidiasis. In these previously reported cases, there was evidence of local invasion of surrounding structures; however, this case is a sentinel report of a fungal abscess without evidence of local structural invasion. The patient's course was complicated by clinical and radiographic worsening to cauda equina syndrome, requiring emergent surgical decompression, despite appropriate antifungal treatment...
September 21, 2018: Clinical Neurology and Neurosurgery
Akihiro Mukaino, Mayumi Tsuda, Satoshi Yamashita, Takayuki Kosaka, Kuniyasu Wada, Yukio Ando
No abstract text is available yet for this article.
September 20, 2018: Clinical Neurology and Neurosurgery
Jun Chen, Yi-Feng Zheng, Si-Cheng Tang, Yi-Qing Zhao, Juan Chen, Yu Wang
OBJECTIVE: We sought to assess the use of surgical treatment, the effect of postoperative adjuvant therapy, and the prognostic factors for survival of patients with primary spinal peripheral primitive neuroectodermal tumors (pPNETs). PATIENTS AND METHODS: The clinical data of 24 patients, who had been surgically treated from April 2003 to February 2018 and in whom immunohistochemical staining results had confirmed the diagnosis of primary spinal pPNETs, were retrospectively analyzed...
September 19, 2018: Clinical Neurology and Neurosurgery
Lishan Yin, Yipeng Han, Guozhuan Miao, Lin Jiang, Sen Xie, Baiyun Liu
OBJECT: This paper is aimed to explore a reasonable guideline for distinguishing whether post-neurosurgical bacterial meningitis has completely been cured, so as to avoid the deficient or excessive treatment for post-neurosurgical bacterial meningitis. PATIENTS AND METHODS: We conducted a retrospective analysis of 46 patients who attended General Hospital of Chinese People's Armed Police Force in Beijing, China, from January 1, 2014 to April 30, 2016. The CSF leukocyte, polykaryocyte, protein and glucose had been tested when their antibiotic treatments were empirically stopped...
September 19, 2018: Clinical Neurology and Neurosurgery
Dana Farahmand, Fee Keil, Marie Göhring, Nazife Dinc, Volker Seifert, Gerhard Marquardt, Sae-Yeon Won, Johanna Quick-Weller
OBJECTIVE: The risk of hemorrhages after stereotactic biopsy is known to be low. Nevertheless hemorrhages in eloquent areas result in neurological deficit for the patients. Since the basal ganglia resemble a particularily high vascularized and eloquent location, which is often the source of hypertensive hemorrhages, we aimed to analyse possible risk factors for hemorrhage after stereotactic biopsy in this region. PATIENTS AND METHODS: We performed a retrospective analysis including patients who underwent stereotactic biopsies of lesions in the basal ganglia between January 2012 and January 2017...
September 18, 2018: Clinical Neurology and Neurosurgery
Karen Chen, Elisabeth B Marsh
OBJECTIVE: Post-stroke fatigue (PSF) is a debilitating complication of stroke recovery. Contributing risk factors, whether they are modifiable, and if they change over time remain understudied. We determine factors associated with PSF and how they evolve from the subacute through chronic phases of recovery. PATIENTS AND METHODS: A consecutive series of patients presenting to our comprehensive stroke center with acute stroke were seen in follow-up within 6 months of infarct and administered the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale to evaluate for PSF...
September 17, 2018: Clinical Neurology and Neurosurgery
Drew A Bednar, E Demetra Bednar
OBJECTIVE: To present the results of a new alternative in the technique lumbar pedicle screw reconstruction in osteopenic bone. Pedicle screw fixation is compromised in osteopenic bone and adjunct fixation commonly requires incremental technology that can increase cost and risk, and which may not commonly be available. Readily available low cost techniques are desirable. PATIENTS AND METHODS: This is a retrospective review of a prospectively accumulated case series of all patients presenting to the senior author's (DAB) practice for elective lumbar reconstruction at a tertiary spine referral center...
September 17, 2018: Clinical Neurology and Neurosurgery
Radu Constantinescu, Kaj Blennow, Lars Rosengren, Barbro Eriksson, Thordis Gudmundsdottir, Yvonne Jansson, Bo Johnels, Annika Renck, Filip Bergquist
OBJECTIVE: Cerebrospinal fluid (CSF) markers of neurodegeneration [neurofilament light chain (NFL), total Tau (T-Tau)], tau pathology [phosphorylated tau (p-Tau)], glial cell damage or activation [glial fibrillary acidic protein (GFAP)], and brain amyloidosis [β-amyloid 1-42 (Aβ42)] are useful for diagnosis and prognosis in several neurodegenerative disorders. In this paper we investigate these markers and their relationship to key clinical milestones in patients with advanced Parkinson´s disease (PD) operated at our center with subthalamic nucleus deep brain stimulation (STN-DBS) for at least 15 years ago...
September 17, 2018: Clinical Neurology and Neurosurgery
Yasushi Shibata, Sumire Ishiyama, Akira Matsushita
OBJECTIVES: Migraine and medication overuse headache are common, but its pathophysiology remains unclear. Differential diagnosis of chronic headache is still challenging. Conventional brain imaging techniques exclude secondary causes of headache but cannot produce a proper diagnosis. Accordingly, more sensitive diagnostic methods are needed for certain diagnosis. In the present study, we performed voxel-wise tract-based spatial statistics of 1.5-T diffusion tensor imaging in migraine patients and healthy volunteers...
September 17, 2018: Clinical Neurology and Neurosurgery
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