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Clinical Neurology and Neurosurgery

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https://www.readbyqxmd.com/read/28214652/unilateral-oculomotor-palsy-in-charcot-marie-tooth-disease-1a-cmt-1a
#1
A Posa, A Emmer, M E Kornhuber
BACKGROUND: Charcot-Marie-Tooth disease (CMT) type 1A is the most common form of CMT 1 and one of the autosomal dominant demyelinating hereditary motor and sensory neuropathies (HMSN). Cranial nerves may be frequently subclinically affected in CMT disease. However manifest clinical signs of cranial nerve involvement are rare. METHODS: This case comprise neurological, ophthalmological, internal medicine and ear-nose-throat investigation, motor and sensory nerve conduction velocity, auditory evoked potentials and orbicularis-oculi reflex measurements, lumbar puncture and blood examination, inclusive molecular genetic testing, as well as electrocardiogram and cranial imaging such as computer tomography and magnetic resonance imaging RESULTS: The present case shows a Charcot-Marie-Tooth (CMT) 1A patient with complete unilateral oculomotor palsy in combination with predominant ipsilateral subclinical trigeminal demyelination...
February 13, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28212928/nonmotor-symptoms-in-de-novo-parkinson-disease-comparing-to-normal-aging
#2
Petra Bago Rožanković, Marjan Rožanković, Lovorka Vučak Novosel, Maristela Stojić
OBJECTIVE: Nonmotor symptoms (NMSs) are common in Parkinson disease (PD), affecting patient's quality of life. The prevalence and domains of NMSs in untreated de novo PD remains unclear, especially comparing to normal aging. The objective was to determine NMSs in untreated de novo PD patients. PATIENTS AND METHODS: We performed a cross-sectional study to evaluate the frequency and severity of NMSs in untreated de novo PD patients (n=71) and age-matched normal controls (n=60) using the Non-Motor Symptoms Scale (NMSS)...
February 11, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28212926/comorbidity-influences-therapeutic-approach-in-multiple-sclerosis
#3
Fioravante Capone, Elisabetta Ferraro, Lucia Florio, Antonella Marcoccia, Vincenzo Di Lazzaro, Giancarlo Di Battista
No abstract text is available yet for this article.
February 11, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28212925/reversible-opercular-syndrome-secondary-to-osmotic-demyelination
#4
Shuchit Pandey, Vikram V Holla, Imran Rizvi, Rakesh Shukla
Opercular syndrome (OPS) is characterized by weakness of facial, masticatory, pharyngeal, laryngeal, tongue and brachial muscles on voluntary command with preservation of emotional and reflexive movements. We report a case of 45year old female who developed the features of OPS due to lesions of bilateral frontal opercular region induced by osmotic demyelination secondary to hyperosmolar hyperglycaemia. On follow up at 6 months, she had complete recovery.
February 11, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28212927/patients-with-chronic-dizziness-following-traumatic-head-injury-typically-have-multiple-diagnoses-involving-combined-peripheral-and-central-vestibular-dysfunction
#5
Q Arshad, R E Roberts, H Ahmad, R Lobo, M Patel, T Ham, D J Sharp, B M Seemungal
OBJECTIVE: We hypothesised that chronic vestibular symptoms (CVS) of imbalance and dizziness post-traumatic head injury (THI) may relate to: (i) the occurrence of multiple simultaneous vestibular diagnoses including both peripheral and central vestibular dysfunction in individual patients increasing the chance of missed diagnoses and suboptimal treatment; (ii) an impaired response to vestibular rehabilitation since the central mechanisms that mediate rehabilitation related brain plasticity may themselves be disrupted...
February 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28226284/does-suboccipital-decompression-and-evacuation-of-intraparenchymal-hematoma-improve-neurological-outcome-in-patients-with-spontaneous-cerebellar-hemorrhage
#6
Katharina A M Hackenberg, Andreas W Unterberg, Carla S Jung, Julian Bösel, Silvia Schönenberger, Klaus Zweckberger
OBJECTIVE: Spontaneous cerebellar hemorrhages (SCH) can lead to life-threatening complications with high mortality rates of 20-50%. Although complications of SCH can be prevented by surgical therapy, there is a lack of consensus concerning the optimal surgical technique for evacuating SCH. METHODS: In this retrospective study 85 patients with SCH were divided into four treatment groups: (1) Decompression and Hematoma Evacuation via suboccipital craniectomy and removal of the posterior arch of C1 (DHE)...
February 3, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28178598/novel-tsc1-and-tsc2-gene-mutations-in-chinese-patients-with-tuberous-sclerosis-complex
#7
Tingting Yu, Yingzhong He, Niu Li, Yunqing Zhou, Zhiping Wang, Qihua Fu, Jiwen Wang, Jian Wang
OBJECTIVE: The study was designed to identify pathogenic TSC1 or TSC2 gene mutations and provide solid evidence for the diagnosis of tuberous sclerosis complex (TSC). METHODS: 11 unrelated Chinese patients with TSC were investigated in the present study. Characteristic skin lesions such as hypomelanotic macules and the central nervous system features such as the epilepsy, cortical tubers and subependymal nodules were the most common symptoms that were observed in the patients...
February 1, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28187368/outcomes-of-autograft-alone-versus-peek-autograft-interbody-fusion-in-the-treatment-of-adult-lumbar-isthmic-spondylolisthesis
#8
Gang Wang, Dunfu Han, Zhenglin Cao, Honggang Guan, Tianhang Xuan
OBJECTIVES: Bone resulting from a complete resection of the posterior arch can be cut into an autograft bone that contains the facet joint structure and morselised bone for interbody fusion. However, whether a strut autograft that contains this trimmed facet joint can produce the same clinical and radiographic outcomes as a cage for interbody fusion remains unclear. The aim of this study was to compare the outcomes of a local facet joint autograft alone to those of polyetheretherketone (PEEK)+autograft for posterior lumbar interbody fusion (PLIF) in the treatment of adult isthmic spondylolisthesis...
January 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28183036/which-one-is-more-effective-for-analgesia-in-infratentorial-craniotomy-the-scalp-block-or-local-anesthetic-infiltration
#9
Eren Fatma Akcil, Ozlem Korkmaz Dilmen, Hayriye Vehid, Lutfiye Serap Ibısoglu, Yusuf Tunali
OBJECTIVES: The most painful stages of craniotomy are the placement of the pin head holder and the skin incision. The primary aim of the present study is to compare the effects of the scalp block and the local anesthetic infiltration with bupivacaine 0.5% on the hemodynamic response during the pin head holder application and the skin incision in infratentorial craniotomies. The secondary aims are the effects on pain scores and morphine consumption during the postoperative 24h. METHODS: This prospective, randomized and placebo controlled study included forty seven patients (ASA I, II and III)...
January 30, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28157623/toxocariasis-of-the-central-nervous-system-with-report-of-two-cases
#10
Bouthouri Abir, Mansour Malek, Mrissa Ridha
Toxocariasis is a parasitic infection caused by the roundworms Toxocara canis or Toxocara cati, mostly due to accidental ingestion of embryonated eggs. Clinical manifestations vary and are classified according to the organs affected. Central nervous system involvement is an unusual complication. Here, we report two cases with neurological manifestations, in which there was cerebrospinal fluid (CSF) eosinophilia with marked blood eosinophilia and a positive serology for Toxocara both in serum and CSF. Improvement of signs and symptoms after specific treatment was observed in the two cases...
January 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28152436/an-individualized-coaching-program-for-patients-with-acute-ischemic-stroke-feasibility-study
#11
P Vanacker, D Standaert, N Libbrecht, I Vansteenkiste, D Bernard, L Yperzeele, G Vanhooren
OBJECTIVES: An individualized stroke care program was developed to match patients' education with their needs regarding stroke knowledge, secondary prevention and rehabilitation. Our purpose was to assess feasibility of in-hospital and post-discharge, personalized stroke coaching service. METHODS: Acute ischemic stroke patients enrolled in ASTRAL-B stroke registry (Sint-Lucashospital, Bruges Belgium) with: (a) hospitalization between 12/2014-12/2015, (b) hospital-to-home discharge, and (c) without cognitive decline, were selected...
January 24, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28129635/calcitonin-gene-related-peptide-monoclonal-antibody-for-preventive-treatment-of-episodic-migraine-a-meta-analysis
#12
REVIEW
Peiwei Hong, Xintong Wu, Yao Liu
Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) have shown promise in the preventive treatment of migraine. Therefore, we performed a meta-analysis to evaluate the efficacy and safety of CGRP mAbs for preventive treatment of migraine. Database including Ovid-SP, Cochrane Library, Pubmed and Web of Science (ISI) were systematically searched up to April 2, 2016 for randomized controlled trials(RCTs) which were dealing with the efficacy and safety of CGRP mAbs for preventive treatment of episodic migraine...
January 22, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28129634/traumatic-subdural-hematoma-is-there-a-weekend-effect
#13
Kavelin Rumalla, Adithi Y Reddy, Manoj K Mittal
OBJECTIVE: Traumatic subdural hematoma (TSDH) is a surgical emergency. The effect of weekend admission on surgery and in-hospital outcomes in TSDH is not known. METHODS: We queried the Nationwide Inpatient Sample from 2002 to 2011 and used ICD-9-CM codes to identify all non-elective admissions with a primary diagnosis of TSDH. We did a subgroup analysis of patients who underwent surgical evacuation. Predictor variables included several patient and hospital characteristics...
January 22, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28129632/analysis-the-causes-of-radiosurgical-failure-in-intracranial-meningiomas-treated-with-radiosurgery
#14
Moinay Kim, Young Hyun Cho, Jeong Hoon Kim, Chang Jin Kim, Do Hoon Kwon
OBJECTIVES: Surgical resection is a primary indication for intracranial meningioma. Radiosurgery is also an excellent treatment modality for postoperative residual tumors, or tumors in high-risk locations, such as the skull base. Despite multimodality treatments, there are some cases in which radiosurgery fails and surgical resection or re-radiosurgery is required. However, there has not been a comprehensive study focusing on the causes of secondary treatment for local recurrence or a new mass that develops outside the target area after radiosurgery...
January 20, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28129633/stereotactic-radiosurgery-versus-surgical-resection-for-spinal-hemangioblastoma-a-systematic-review
#15
REVIEW
Kelly J Bridges, Jerry J Jaboin, Charlotte D Kubicky, Khoi D Than
Spinal cord hemangioblastomas are benign vascular tumors arising sporadically in approximately 70-80% of cases. They can also be manifestations of von Hippel-Lindau (VHL) disease, as these patients will often have multiple spinal hemangioblastomas. Historically, surgical management of symptomatic intramedullary hemangioblastomas has been considered the treatment of choice. However, recently, stereotactic radiosurgery has been utilized as an adjuvant therapeutic modality, and some have suggested it may have utility as the primary treatment option for these tumors...
January 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28118941/comment-on-sensory-motor-axonal-polyneuropathy-involving-cranial-nerves-an-uncommon-manifestation-of-disulfiram-toxicity-santos-et-al-clin-neurol-neurosurg-152-12-15-2016
#16
LETTER
Petros N Karamanakos, Eleftheria S Panteli
No abstract text is available yet for this article.
January 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28113102/key-clinical-milestones-15-years-and-onwards-after-dbs-stn-surgery-a-retrospective-analysis-of-patients-that-underwent-surgery-between-1993-and-2001
#17
Radu Constantinescu, Barbro Eriksson, Yvonne Jansson, Bo Johnels, Björn Holmberg, Thordis Gudmundsdottir, Annika Renck, Peter Berglund, Filip Bergquist
OBJECTIVE: Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for motor fluctuations in Parkinson's disease (PD), but does not halt disease progression. The long-term deterioration of key functions such as cognition, speech, ability to swallow, gait, urinary bladder control, orientation and reality perception is decisive for patients' independency in daily life. In this paper we investigated patients with advanced PD operated at our center with STN-DBS for at least 15 years ago, in respect to key clinical milestones reflecting their overall function in daily living...
January 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28131967/the-role-of-therapeutic-hypothermia-in-the-management-of-acute-spinal-cord-injury
#18
REVIEW
Nikolay L Martirosyan, Arpan A Patel, Alessandro Carotenuto, M Yashar S Kalani, Michael A Bohl, Mark C Preul, Nicholas Theodore
This review paper investigates the history, efficacy, and administration of systemic and local hypothermia for spinal cord injury (SCI). It summarizes the published experimental and clinical evidence on hypothermia for SCI and analyzes the potential for further research. Early experimental animal research showed that local hypothermia improved recovery and gain of function after acute SCI. However, in the early 1970s, clinical research findings did not coincide with results of these animal trials, which led to a loss of interest in local hypothermia...
January 17, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28129631/treatment-of-brainstem-cavernous-malformations
#19
EDITORIAL
Aatman Shah, Henry Jung
No abstract text is available yet for this article.
January 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28107674/mitochondrial-serine-hydroxymethyltransferase-2-is-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#20
Bo Wang, Wei Wang, ZhiZhong Zhu, XueBin Zhang, Fan Tang, Dong Wang, Xi Liu, XiaoLing Yan, Hao Zhuang
OBJECTIVE: Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of SHMT2 in glioma is not clear. In this study, we sought to examine the expression of SHMT2 in glioma, the association between SHMT2 expression and clinicopathological characteristics, and the association of SHMT2 expression with prognosis in glioma patients...
January 16, 2017: Clinical Neurology and Neurosurgery
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