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Clinical Neurology and Neurosurgery

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https://www.readbyqxmd.com/read/29449082/multiple-sclerosis-or-inflammatory-cadasil-case-report-and-review-of-the-literature
#1
N Schiess, K Huether, M Szolics, G Agarwal, A W El-Hattab, S Sathe
BACKGROUND: Multiple sclerosis (MS) and CADASIL presenting together is exceedingly rare. As more cases of "inflammatory" CADASIL emerge, diagnostic challenges for clinicians increase. We report an individual with MS and CADASIL presenting with cognitive decline at age 25. She presented with gadolinium enhancing lesions on MRI and inflammatory cerebrospinal fluid raising the question of whether these patients should be given a diagnosis of "inflammatory CADASIL" or both MS and CADASIL...
February 8, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29448188/genotype-phenotype-and-in-silico-pathogenicity-analysis-of-hexb-mutations-panel-based-sequencing-for-differential-diagnosis-of-gangliosidosis
#2
Nejat Mahdieh, Sahar Mikaeeli, Ali Reza Tavasoli, Zahra Rezaei, Majid Maleki, Bahareh Rabbani
OBJECTIVES: Gangliosidosis is an inherited metabolic disorder causing neurodegeneration and motor regression. Preventive diagnosis is the first choice for the affected families due to lack of straightforward therapy. Genetic studies could confirm the diagnosis and help families for carrier screening and prenatal diagnosis. An update of HEXB gene variants concerning genotype, phenotype and in silico analysis are presented. PATIENTS AND METHODS: Panel based next generation sequencing and direct sequencing of four cases were performed to confirm the clinical diagnosis and for reproductive planning...
February 8, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29438856/the-surgical-management-of-dysphagia-secondary-to-diffuse-idiopathic-skeletal-hyperostosis
#3
Y C Lui Jonathan, P Sayal, G Prezerakos, V Russo, D Choi, A T H Casey
OBJECTIVE: This study reviews the management pathway and surgical outcomes of patients referred to and operated on at a tertiary neurosurgical centre, for dysphagia associated with anterolateral cervical hyperostosis (ACH) in diffuse idiopathic skeletal hyperostosis (DISH). PATIENTS & METHODS: Electronic patient records for 6 patients who had undergone anterior cervical osteophytectomy for dysphagia secondary to ACH were reviewed. ACH diagnosis was made by an Ear, Nose and Throat (ENT) specialist and patients were referred to a neurosurgical-led multidisciplinary team (MDT) for review...
February 7, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29433056/optic-nerve-sheath-diameter-based-on-preoperative-brain-computed-tomography-and-intracranial-pressure-are-positively-correlated-in-adults-with-hydrocephalus
#4
Hyung-Chul Lee, Won-Jong Lee, Yun-Sik Dho, Won-Sang Cho, Yong Hwy Kim, Hee-Pyoung Park
OBJECTIVE: The usefulness of optic nerve sheath diameter (ONSD) in predicting increased intracranial pressure (ICP) is not well established in adults with hydrocephalus. In this retrospective study, we evaluated the correlation between ONSD measured on brain computed tomography (CT) and ICP in adults with hydrocephalus. PATIENTS AND METHODS: ONSDs were measured on preoperative brain CT images from 64 adult patients with hydrocephalus who underwent extracranial ventricular drainage or a ventriculoperitoneal shunt in 2016...
February 7, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29433055/presurgical-treatment-with-somatostatin-analogues-in-growth-hormone-secreting-pituitary-adenomas-a-long-term-single-center-experience
#5
Liang Lv, Yu Hu, Peizhi Zhou, Shizhen Zhang, Senlin Yin, Nannan Zhang, Shu Jiang
OBJECTIVE: Acromegalic patients with macro- or giant adenomas often had poor prognosis after surgery. Somatostatin analogues (SSAs) show high effectiveness in both tumor shrinkage and serum GH reduction. But the role of SSAs in pre-surgical treatment and the management among macro- and giant adenomas remains controversial. PATIENTS AND METHODS: A total of 100 acromegalic patients with macro- or giant adenomas that underwent surgery in our institution between January 2010 and December 2016 were enrolled in the current retrospective study...
February 6, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29428625/anterior-versus-posterior-approaches-for-thoracic-disc-herniation-association-with-postoperative-complications
#6
Panagiotis Kerezoudis, Kenan R Rajjoub, Sandy Goncalves, Mohammed Ali Alvi, Mohamed Elminawy, Abdullah Alamoudi, Ahmad Nassr, Elizabeth B Habermann, Mohamad Bydon
OBJECTIVE: Thoracic disc herniations (TDH) represent 1.5-4% of all intervertebral disc herniations. Surgical treatment can be divided into anterior, lateral and posterior approaches and is an area of contention in the literature. Available evidence consists mostly of single-arm, single-institutional studies with limited sample sizes. The objective of this study is to investigate 30-day surgical outcomes following excision of TDH utilizing a national surgical registry. PATIENTS AND METHODS: The American College of Surgeons - National Surgical Quality Improvement Program (ACS-NSQIP) was queried for cases that underwent anterior (thoracotomy or thoracoscopy), lateral (extracavitary or costotransversectomy) or posterior (transpedicular or laminectomy) surgery for a primary diagnosis of TDH between 2012 and 2015...
February 6, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29425742/the-analysis-of-the-cerebral-venous-blood-volume-in-cavernous-sinus-using-320-row-multi-detector-ct
#7
Katsuhiro Mizutani, Masahiro Toda, Yumi Yajima, Takenori Akiyama, Hirokazu Fujiwara, Kazunari Yoshida, Masahiro Jinzaki
OBJECTIVES: Functional venous anatomy in the brain has been mostly understood from the morphological and embryological points of view and no published study has directly evaluated the blood flow volume of cerebral small veins. We developed a method to directly evaluate the relative blood volume in small venous channels using multi-detector computed tomography (CT) and applied it to evaluate the blood volume in each tributary of the cavernous sinus, which plays an important role in cerebral venous drainage...
February 6, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29425743/is-mgmt-promoter-methylation-to-be-considered-in-the-decision-making-for-recurrent-surgery-in-glioblastoma-patients
#8
Andrej Pala, Anne Lea Schmitz, Andreas Knoll, Max Schneider, Michal Hlavac, Ralph König, Christian Rainer Wirtz, Jan Coburger
OBJECTIVES: At present, there is no standard therapy approved for recurrent glioblastoma (rGB). In particular, the counselling of patients with an unmethylated O6-methylguanine-DNA methyltransferase (MGMT) promoter GB remains a challenge. Our aim was to compare the overall survival (OS) and progression free survival (PFS) in patients treated surgically and non-surgically at the time of GB recurrence. This was evaluated with particular reference to the impact of recurrent surgery for patients with unmethylated MGMT promoter rGB...
February 5, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29425741/patterns-of-care-and-outcomes-of-postoperative-radiation-for-intracranial-hemangiopericytoma-in-united-states-hospitals
#9
Anna Lee, Baho Sidiqi, Arthur Wang, Joseph Safdieh, David Schreiber
OBJECTIVE: Several small (<100 patients) studies have been suggestive of a survival benefit associated with postoperative radiation for intracranial hemangiopericytoma. Given the rarity of this disease, we sought to examine the patterns of care and outcomes of this tumor in the National Cancer Database (NCDB). PATIENTS AND METHODS: We accessed the NCDB to identify patients with intracranial hemangiopericytoma between 2004-2012. Patients were categorized by surgical status, postoperative radiation usage, and location (meningeal or brain parenchyma)...
February 5, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408772/cervical-spine-surgery-for-tandem-spinal-stenosis-the-impact-on-low-back-pain
#10
Matthew D Alvin, Vincent J Alentado, Daniel Lubelski, Edward C Benzel, Thomas E Mroz
STUDY DESIGN: Retrospective Cohort. OBJECTIVE: Tandem spinal stenosis (TSS) can present similarly to cervical myelopathy, but often has a worse prognosis. Few studies have investigated outcomes and compared treatment approaches for patients with TSS. We sought to determine the impact of cervical spine surgery on cervical and lumbar spine symptoms in patients with symptomatic tandem spinal stenosis. PATIENTS METHODS: 84 patients with TSS were identified over 5 years...
February 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408768/craniopharyngiomas-a-systematic-review-and-evaluation-of-the-current-intratumoral-treatment-landscape
#11
REVIEW
Oliver D Mrowczynski, Sara T Langan, Elias B Rizk
Cushing once described craniopharyngiomas as the most forbidding tumor; and, despite surgical advances decades later, craniopharyngioma resection is still extremely complex due to its location and infiltration into local structures, making gross total resection challenging. Adjuvant treatments include radiation and chemotherapy, but intratumoral therapy may emerge as an adjuvant treatment for craniopharyngiomas. Here, we present a review of the literature on this treatment modality; and, summarize the available reported cases to underline usefulness and effectiveness of this treatment method...
February 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29427894/clinical-characteristics-associated-with-the-intracranial-dissemination-of-gliomas
#12
Xu Cai, Jun-Jie Qin, Shu-Yu Hao, Huan Li, Chun Zeng, Sheng-Jun Sun, Lan-Bing Yu, Zhi-Xian Gao, Jian Xie
OBJECTIVES: Glioma is the most common malignant tumor of the brain and the intracranial dissemination of gliomas is the late stage of the development of the tumor. However, there is little research in literature on the occurrence of intracranial dissemination of gliomas. In order to provide a reference for clinical work, we carried out this study on intracranial dissemination of glioma. PATIENTS AND METHODS: A total of 629 patients with gliomas received tumor resection by the same surgeon from August 2010 to September 2015 were included in this study...
February 1, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29414152/inflammation-role-in-sensory-neuropathy-in-chinese-patients-with-diabetes-prediabetes
#13
Jing Zeng, Yalin Xu, Yao Shi, Chenyin Jiang
OBJECTIVES: Prediabetes involves people with glucose-metabolism impairment, and is related to different diabetic complications, like peripheral neuropathy. We aimed to explore the relationship among inflammatory (tumor necrosis factor alpha [TNFα]) and antiinflammatory (interleukin 10 [IL10]) cytokines as well as neuropathy of very distal-sensory-nerves in Chinese patients with prediabetes/diabetes. PATIENTS AND METHODS: In the present study, 55 patients having prediabetes, 55 patients having type 2 diabetes mellitus (DM), and 48 controls were included...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29414151/migrainous-aura-as-stroke-mimic-the-role-of-perfusion-computed-tomography
#14
Mariana Ridolfi, Antonio Granato, Paola Polverino, Giovanni Furlanis, Maja Ukmar, Irene Zorzenon, Paolo Manganotti
OBJECTIVES: The acute-onset of migrainuos aura (MA) can be erroneously diagnosed in Emergency Department (ED) as acute stroke (AS) and it can be classified as "stroke mimic" (SM). Perfusion computer tomography (PCT) may be useful to improve detection of infarcts. The aim of the study was to investigate the role in ED of PCT in improving diagnosis of migrainous aura. Data were compared with the well-defined perfusion patterns in patients with acute ischemic stroke. PATIENTS AND METHODS: A standardized Stroke Protocol was planned...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408780/role-of-radiotherapy-in-residual-pineal-parenchymal-tumors
#15
Narendra Kumar, Gulladamane Yogesh Srinivasa, Renu Madan, Pravin Salunke
OBJECTIVES: Surgical excision of pineal parenchymal tumors(PPT), though desirable for good long term outcome, may not always be possible. Role of adjuvant radiotherapy (RT) in residual PPT's is not well delineated. The purpose of this single institutional retrospective study is to assess the role of radiotherapy in residual PPT's. PATIENTS AND METHODS: Between 2006-2016, fourteen patients with residual PPT's were treated with adjuvant radiotherapy (12 with 3D conformal RT)...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408779/pathogenic-significance-of-scn1a-splicing-variants-causing-dravet-syndrome-improving-diagnosis-with-targeted-sequencing-for-variants-by-in-silico-analysis
#16
Nejat Mahdieh, Sepideh Mikaeeli, Reza Shervin Badv, Azadeh Gharehzadeh Shirazi, Majid Maleki, Bahareh Rabbani
OBJECTIVES: Genetic heterogeneity of epileptic encephalopathy (IEE) mandates the use of gene-panels for diagnosis. PATIENTS AND METHODS: A 36-gene-panel next-generation sequencing was applied for IEE in two Iranian families. A literature search was performed using keywords to identify reported splicing mutations in SCN1A and perform genotype-phenotype correlation. RESULTS: An update of splicing mutations revealed 147 variants with 65.75% of them de novo mutations...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408778/increased-serum-levels-of-tnf-%C3%AE-and-decreased-serum-levels-of-il-27-in-patients-with-parkinson-disease-and-their-correlation-with-disease-severity
#17
Ebrahim Kouchaki, Reza Daneshvar Kakhaki, Omid Reza Tamtaji, Ehsan Dadgostar, Mohammad Behnam, Hassan Nikoueinejad, Hossein Akbari
OBJECTIVES: Immunological basis of neurodegenerative diseases including Alzheimer and Parkinson disease (PD) has some important roles in their pathogenesis. There are conflicting studies to serum level of TNF-α in PD. Also, according to our finding there is no report evaluating serum level of IL-27 in PD. This study correlates the serum level of those factors with severity of PD. PATIENTS AND METHODS: In this case-control study, 83 patients with PD and 83 healthy volunteers were enrolled...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408767/the-woven-endobridge-web-for-endovascular-therapy-of-intracranial-aneurysms-update-of-a-systematic-review-with-meta-analysis
#18
Noam Tau, Udi Sadeh-Gonik, Gilles Aulagner, Francis Turjman, Benjamin Gory, Xavier Armoiry
OBJECTIVES: Endovascular treatment of wide-neck intracranial aneurysms (IAs) is challenging, especially in bifurcation location. The intra-saccular flow-disruptor Woven EndoBridge (WEB) offers a new concept of endovascular therapy for wide-neck IAs. We performed an update of a systematic review aimed to report the feasibility, effectiveness and safety of WEB device therapy. PATIENTS AND METHODS: A systematic review was conducted using several electronic databases (including PUBMED and EMBASE), searching for studies published between October 2015 and December 2017 (those published between January 2010 and September 2015 were included in our initial systematic review)...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408766/sunct-like-syndrome-preceding-acute-ophthalmic-distribution-zoster-a-case-report-and-review-of-the-literature
#19
Joerg Philipps, Adonis Bytyqi, Blerta Salihaj, Peter Dieter Schellinger
BACKGROUND: SUNCT like syndrome has been observed as a post zoster condition, as a syndrome associated with overt ophthalmic zoster after appearance of herpetic lesions and in varicella zoster virus meningoencephalitis without rash. However, SUNCT like syndrome fully consistent and congruent with the criteria of the ICHD immediately before onset of an ophthalmic-distribution zoster has not been reported. CASE PRESENTATION: We report 73-year-old patient with a SUNCT like syndrome as the first presentation of an acute ophthalmic-distribution zoster...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408777/streamlined-triage-and-transfer-protocols-improve-door-to-puncture-time-for-endovascular-thrombectomy-in-acute-ischemic-stroke
#20
Akash P Kansagra, Adam N Wallace, David R Curfman, James D McEachern, Christopher J Moran, DeWitte T Cross, Jin-Moo Lee, Andria L Ford, S Goyal Manu, Peter D Panagos, Colin P Derdeyn
OBJECTIVE: Shorter time from symptom onset to treatment is associated with improved outcomes in patients who undergo mechanical thrombectomy for treatment of acute ischemic stroke due to emergent large vessel occlusion. In this work, we detail pre-thrombectomy process improvements in a multi-hospital network and report the effect on door-to-puncture time in patients undergoing mechanical thrombectomy. PATIENTS AND METHODS: A streamlined workflow was adopted to minimize door-to-puncture time...
January 30, 2018: Clinical Neurology and Neurosurgery
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