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Clinical Journal of Pain

Kelly C Young-Wolff, Daniella Klebaner, Constance Weisner, Michael Von Korff, Cynthia I Campbell
OBJECTIVES: Smokers on chronic opioid therapy for non-cancer pain use prescription opioids at higher dosages and are at increased risk for opioid misuse and dependence relative to non-smokers. The current study aims to assess whether smoking is associated with problems and concerns with chronic opioid therapy from the perspective of the patient. METHODS: In a large sample (N=972) of adult patients prescribed opioids for chronic noncancer pain, we examined sex-specific associations between smoking status and patient perceptions of problems and concerns with chronic opioid therapy using regression analyses, adjusting for covariates...
November 28, 2016: Clinical Journal of Pain
Matthew S Herbert, Burel R Goodin, Hailey W Bulls, Adriana Sotolongo, Megan E Petrov, Jeffrey C Edberg, Laurence A Bradley, Roger B Fillingim
OBJECTIVES: While several factors are known to contribute to ethnic differences in pain, relatively little attention has been devoted to physiological factors. Our first aim was to examine the relationship between cortisol and pain responses during a cold-pressor task (CPT) among African American (AA) and non-Hispanic White (NHW) adults with knee osteoarthritis (OA). Our second aim was to assess the relationship between perceived racial discrimination and cortisol among AA participants...
November 28, 2016: Clinical Journal of Pain
Anthony Wright, Heather A E Benson, Rob Will, Penny Moss
OBJECTIVES: Cold hyperalgesia has been established as an important marker of pain severity in a number of conditions. This study aimed to establish the extent to which patients with knee osteoarthritis (OA) demonstrate widespread cold, heat, and pressure hyperalgesia. OA participants with widespread cold hyperalgesia were compared with the remaining OA cohort to determine whether they could be distinguished in terms of hyperalgesia, pain report, pain quality, and physical function. METHODS: A total of 80 participants with knee OA and 40 matched healthy controls participated...
November 24, 2016: Clinical Journal of Pain
Robert N Jamison, Dylan C Jurcik, Robert R Edwards, Chuan-Chin Huang, Edgar L Ross
OBJECTIVES: The overall aim of this study was to determine the effect of introducing a smartphone pain app, for both Android and iPhone devices that enables chronic pain patients to assess, monitor, and communicate their status to their providers. METHODS: This study recruited 105 chronic pain patients to use a smartphone pain app and half of the subjects (N=52) had 2-way messaging available through the app. All subjects completed baseline measures and were asked to record their progress every day for 3 months, with the opportunity to continue for 6 months...
November 24, 2016: Clinical Journal of Pain
Junko Nagai, Yoshihiro Uesawa, Ryotaro Shimamura, Hajime Kagaya
OBJECTIVES: Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are antipyretic analgesics with established adverse effects; however, only a few studies have compared their adverse effects simultaneously. We aimed to compare the adverse effects of these medications to confirm the respective frequencies of both rare and major adverse effects. METHODS: We used a high-quality database for spontaneous adverse drug event reporting in Japan. Data were extracted regarding the adverse effects of acetaminophen and NSAIDs to compare the tendency of the appearance of those adverse effects between the drugs...
November 24, 2016: Clinical Journal of Pain
Xiaoxiao Pan, Hongguang Bao, Yanna Si, Chenjie Xu, Hao Chen, Xianzhong Gao, Xinyi Xie, Yajie Xu, Fan Sun, Lingqing Zeng
OBJECTIVES: Parasthesia free stimulation, such as high frequency and burst have been demonstrated as effective therapies for neuropathic pain. The aim of this meta-analysis was to evaluate the efficacy and safety of conventional spinal cord stimulation (SCS) in the treatment of refractory angina pectoris (RAP). METHODS: Relevant randomized controlled trial (RCT) studies that investigated SCS for patients with RAP were comprehensively searched in Medline, Pubmed, Embase, and Cochrane Library...
November 21, 2016: Clinical Journal of Pain
Ann-Kristin Ruhe, Michael Frosch, Julia Wager, Roland Linder, Ingo Pfenning, Dirk Sauerland, Boris Zernikow
OBJECTIVES: The aim of this study was to analyze changes in health care utilization and cost among a sample of highly impaired children and adolescents who sought a three-week intensive interdisciplinary pain treatment (IIPT). MATERIALS AND METHODS: Claims data from seven statutory health insurance companies were analyzed for 65 children and adolescents who sought IIPT at the German Paediatric Pain Centre. The annual health care utilization and cost were determined for the following four areas: outpatient care, inpatient care, medications, and remedies and aids...
November 18, 2016: Clinical Journal of Pain
Mengqiang Luo, Xiaoming Liu, Li Ning, Yuan Sun, Ying Cai, Sai'e Shen
OBJECTIVES: Patients experience severe pain after pectus excavatum (PE) surgery. The aim of this prospective, randomized study was to compare analgesic effects of ultrasonography-guided bilateral intercostal nerve blocks (UG-ICNBs) with those of conventional patient-controlled intravenous analgesia (PCIA) on acute pain after the Nuss procedure for PE repair in children. METHODS: A prospective randomized study was performed in children with PE who were scheduled for the Nuss procedure...
November 10, 2016: Clinical Journal of Pain
Gunther Landmann, Wolfgang Dumat, Niklaus Egloff, Andreas R Gantenbein, Sibylle Matter, Roberto Pirotta, Peter S Sándor, Wolfgang Schleinzer, Burkhardt Seifert, Heiko Sprott, Lenka Stockinger, Franz Riederer
OBJECTIVES: Widespread sensory deficits resembling hemihypoaesthesia occur in 20-40% of chronic pain patients on the side of pain, independent of pain aetiology, and have been termed nondermatomal sensory deficits (NDSD). Sensory profiles have rarely been investigated in NDSD. METHODS: Quantitative sensory testing (QST) according to the protocol of the German Research Network on Neuropathic Pain (DFNS) was performed in the face, hand and foot of the painful body side and in contralateral regions in chronic pain patients...
November 10, 2016: Clinical Journal of Pain
Christopher D King, Kristen E Jastrowski Mano, Kimberly A Barnett, Megan Pfeiffer, Tracy V Ting, Susmita Kashikar-Zuck
OBJECTIVES: Reduced pain thresholds have been documented in adult fibromyalgia but there are no quantitative studies of altered pain sensitivity in adolescents with juvenile fibromyalgia (JFM). The current study examined differences in pressure pain sensitivity between adolescent females with JFM and healthy controls. The relationship between levels of anxiety and pain were also examined. METHODS: A total of 34 JFM (15.4±1.4▒y old) and 31 controls (14.5±1.3▒y old) completed self-report measures of pain and anxiety...
November 10, 2016: Clinical Journal of Pain
Nancy Carnide, Sheilah Hogg-Johnson, Pierre Côté, Emma Irvin, Dwayne Van Eerd, Mieke Koehoorn, Andrea Furlan
OBJECTIVES: Musculoskeletal disorders (MSDs) are a common source of work disability. Opioid prescribing for MSDs has been on the rise, despite a lack of data on effectiveness. The objective was to conduct a systematic review to determine whether early receipt of opioids is associated with future work outcomes among workers with MSDs compared to other analgesics, no analgesics, or placebo. METHODS: MEDLINE, EMBASE, CINAHL, and CENTRAL were searched from inception to 2014 and reference lists were scanned...
November 10, 2016: Clinical Journal of Pain
Caroline F Pukall, Sophie Bergeron, Candace Brown, Gloria Bachmann, Ursula Wesselmann
OBJECTIVES: Vulvodynia (idiopathic chronic vulvar pain) is a prevalent condition associated with significant and negative impacts in many areas of function. Despite the increased research interest in vulvodynia in recent years, recommendations for outcome measures for use in clinical trials are missing. The purpose of this paper, therefore, was to provide recommendations for outcome measures for vulvodynia clinical trials so that consistent measures are used across trials in order to facilitate between-study comparisons and the conduct of large multi-center trials, and to improve measurement of the multiple dimensions of vulvodynia...
November 10, 2016: Clinical Journal of Pain
Rita Canaipa, Alexandre Castro-Caldas, João Manuel Moreira, Fernando Pimentel-Santos, Jaime Cunha Branco, Roi Treister
OBJECTIVES: Fibromyalgia (FM), a chronic pain condition, is associated with abnormalities in pain modulation. A growing body of evidence has shown that social distress modulates pain sensitivity. The current study aimed to assess the effects of social distress manipulation on pain in FM patients compared with positive (rheumatoid arthritis, RA) and negative (pain-free) controls. MATERIALS AND METHODS: FM, RA patients and healthy controls (HC) were recruited. Demographic, medical, and psychological data were collected...
November 10, 2016: Clinical Journal of Pain
Melissa Santos, Taylor Murtaugh, Ashley Pantaleao, William T Zempsky, Jessica W Guite
OBJECTIVES: Pediatric obesity and chronic pain are two of the most significant public health crises affecting youth today. Despite the high number of youth experiencing both chronic pain and obesity, little research has been done examining their relationship. This study aims to both replicate and extend this research base. METHODS: A retrospective chart review of 99 patients presenting for evaluation in a pediatric pain clinic was conducted. Demographic information, including patient weight status, and self-report measures completed by both patients and their parents, including the Pain Frequency-Severity-Duration scale, the Functional Disability Inventory (FDI) and the Pain Catastrophizing Scale were examined...
November 10, 2016: Clinical Journal of Pain
Keith G Wilson, Adam Heenan, John Kowal, Peter R Henderson, Lachlan A McWilliams, Dyana Castillo
OBJECTIVES: The interpersonal theory of suicide offers a conceptual framework for understanding suicidal ideation (SI) that may be applicable to individuals with chronic pain. The theory emphasizes the importance of two interpersonal constructs as precursors to SI: perceived burdensomeness (the belief that one has become a burden to others) and thwarted belongingness (a lack of social integration or connection). Our objective was to test the interpersonal theory of suicide in people with chronic pain...
October 20, 2016: Clinical Journal of Pain
Caterina Magnani, Diana Giannarelli, Giuseppe Casale
OBJECTIVES: To assess the prevalence of breakthrough pain (BTP) provoked by 6 common procedures in patients with advanced disease. METHODS: A prospective, cross-sectional, multicenter, national study was performed in 23 palliative care units in Italy. Patients were recruited if they were undergoing one of the following procedures as part of normal care: turning, personal hygiene care, transfer from bed to chair, bladder catheterization, pressure ulcer care, and subcutaneous drug administration...
October 20, 2016: Clinical Journal of Pain
Cynthia L Huffman, James N Goldenberg, James Weintraub, Luis Sanin, Joseph Driscoll, Ruoyong Yang, Marci L Chew, Joseph M Scavone
OBJECTIVES: To assess efficacy and safety of once-daily controlled-release (CR) formulation of pregabalin in patients with postherpetic neuralgia (PHN). METHODS: A randomized withdrawal trial, with 6-week single-blind pregabalin treatment phase and 13-week double-blind phase, where patients with ≥50% decrease in mean pain score at single-blind end point from baseline were randomized (1:1) to pregabalin CR (82.5-660 mg d) or placebo. Primary efficacy outcome was time to loss of therapeutic response (LTR; <30% decrease in weekly mean pain score from single-blind baseline or discontinuation due to adverse event [AE] or lack of efficacy)...
October 6, 2016: Clinical Journal of Pain
Pamela Angle, Christine Kurtz Landy, Jasmine Djordjevic, Jon Barrett, Alanna Kibbe, Saiena Sriparamananthan, Yuna Lee, Lydia Hamata, Alex Kiss
OBJECTIVES: The Angle Labor Pain Questionnaire (A-LPQ) is a new, condition-specific, multidimensional psychometric instrument which measures the most important dimensions of women's childbirth pain experiences using 5 subscales: The Enormity of the Pain, Fear/Anxiety, Uterine Contraction Pain, Birthing Pain and Back Pain/Long Haul. This study assessed the A-LPQ's test-retest reliability during early active labor without pain relief. METHODS: Two versions of the A-LPQ were randomly administered during 2 test sessions separated by a 20 minute window...
September 28, 2016: Clinical Journal of Pain
Anoop Kuttikat, Maliha Shaikh, Amin Oomatia, Richard Parker, Nicholas Shenker
OBJECTIVES: Delays in diagnosis occur with Complex Regional Pain Syndrome (CRPS). We define and prospectively demonstrate that novel bedside tests measuring body perception disruption can identify patients with CRPS post-fracture. METHODS: The objectives of our study were to define and validate four bedside tests; to identify the prevalence of positive tests in patients with CRPS and other chronic pain conditions and to assess the clinical utility (Sensitivity; Specificity; Positive Predictive value; Negative Predictive Value) for identifying CRPS within a Fracture cohort...
September 21, 2016: Clinical Journal of Pain
Lauren E Friedman, Bizu Gelaye, Paul A Bain, Michelle A Williams
BACKGROUND: Previous studies have demonstrated an association between migraine and major depressive disorder. However, relatively little is known about the relationship between suicidal ideation, with or without concurrent depression, and migraine. OBJECTIVE: We conducted a systematic literature review to synthesize the available research focused on investigating the association of migraine with suicidal ideation. METHODS: Relevant research papers were identified through searches of major electronic databases including PubMed, Embase (Elsevier), Web of Science (Thomson Reuters), PsycINFO (EBSCO), and Google Scholar...
September 17, 2016: Clinical Journal of Pain
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