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Clinical Journal of Pain

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https://www.readbyqxmd.com/read/28448426/orexin-receptor-antagonism-in-painful-diabetic-neuropathy-a-phase-2-trial-with-filorexant
#1
W Joseph Herring, Joy Y Ge, Saheeda Jackson, Christopher Assaid, Kathryn M Connor, David Michelson
OBJECTIVES: To evaluate whether orexin receptor antagonism with filorexant provides pain relief in patients with painful diabetic neuropathy (PDN). METHODS: In this double-blind, placebo-controlled, enriched-enrollment, randomized-withdrawal proof-of-concept study, patients with PDN (aged 18-75 y) entered a 2-week, single-blind active run-in period with filorexant 10 mg nightly, before randomization 1:1 to placebo or filorexant in a 2-week, double-blind treatment period...
April 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28448425/vulnerability-to-psychopathology-and-dimensions-of-personality-in-patients-with-fibromyalgia
#2
Alba Garcia-Fontanals, Mariona Portell, Susanna García-Blanco, Violant Poca-Dias, Ferran García-Fructuoso, Marina López-Ruiz, Teresa Gutiérrez-Rosado, Montserrat Gomà-I-Freixanet, Joan Deus
OBJECTIVE: Fibromyalgia (FM) patients may present psychopathology and some characteristic personality traits that may affect their adaptation to the disease. This paper aims to study the relationship between personality dimensions according to the psychobiological model of Cloninger and the presence of psychopathology. METHOD: The study sample consisted of 42 patients with FM and 38 healthy controls. The assessment instruments administered were the Temperament and Character Inventory (TCI-R) and the Millon Clinical Multiaxial Inventory (MCMI-III)...
April 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28430671/elevated-production-of-nociceptive-cc-chemokines-and-se-selectin-in-patients-with-low-back-pain-and-the-effects-of-spinal-manipulation-a-non-randomized-clinical-trial
#3
Julita A Teodorczyk-Injeyan, Marion McGregor, John J Triano, H Stephen Injeyan
BACKGROUND: The involvement of inflammatory components in the pathophysiology of low back pain is poorly understood. It has been suggested that spinal manipulative therapy (SMT) may exert anti-inflammatory effects. PURPOSE: To determine the involvement of inflammation-associated chemokines (CC series) in the pathogenesis of non-specific low back pain and to evaluate the effect of SMT on that process. METHODS: Patients presenting with non-radicular, non-specific low back pain (minimum pain score 3 on 10 point visual analogue scale, VAS) were recruited according to stringent inclusion criteria...
April 19, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28398916/attentional-avoidance-is-associated-with-increased-pain-sensitivity-in-patients-with-chronic-posttraumatic-pain-and-comorbid-posttraumatic-stress
#4
Mathea Harvold, Colin MacLeod, Henrik Bjarke Vaegter
OBJECTIVES: Posttraumatic stress disorder (PTSD) is common in chronic posttraumatic pain. Theoretical models suggest that attentional biases (AB) contribute to the development and maintenance of chronic pain and PTSD, however, the influence of AB on clinical and heat pain sensitivity in chronic posttraumatic pain patients is unknown. This study investigated AB for linguistic pain- and trauma-related stimuli, and clinical and thermal sensitivity in patients with chronic posttraumatic pain with and without PTSD...
April 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28383293/peripheral-nerve-block-as-a-supplement-to-light-or-deep-general-anesthesia-in-elderly-patients-receiving-total-hip-arthroplasty-a-prospective-randomized-study
#5
Bin Mei, Hanning Zha, Xiaolong Lu, Xinqi Cheng, Shishou Cheng, Xuesheng Liu, Yuanhai Li, Erwei Gu
BACKGROUND: Peripheral nerve block combined with general anesthesia is a preferable anesthesia method for elderly patients receiving hip arthroplasty. The depth of sedation may influence patient recovery. Therefore, we aimed to investigate the influence of peripheral nerve blockade and different intraoperative sedation levels on the short-term recovery of elderly patients receiving total hip arthroplasty. METHODS: Patients aged 65 years and older undergoing total hip arthroplasty were randomized into three groups: a general anesthesia without lumbosacral plexus block group, and two general anesthesia plus lumbosacral plexus block groups, each with a different level of sedation (light or deep)...
April 5, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28379874/effects-of-single-nucleotide-polymorphisms-on-surgical-and-post-surgical-opioid-requirements-a-systematic-review-and-meta-analysis
#6
Siu-Wai Choi, David M H Lam, Stanley S C Wong, Haydn H C Shiu, Amy X M Wang, Chi-Wai Cheung
OBJECTIVES: There is great heterogeneity in the way individuals respond to medications. Inherited differences, such as Single Nucleotide Polymorphisms (SNP), can influence the efficacy and toxicity of drugs. This meta-analysis aims to collate data from studies investigating the effect of SNPs on post-operative and/or intra-operative opioid requirements. METHODS: This meta-analysis was conducted following PRISMA guidelines. Eligibility criteria for studies in this meta-analysis were reporting amount of post-operative and/or intra-operative opioid used as the primary outcome and genotyping patients for SNPs in one of the following genes; OPRM1, CYP2D6, CYP3A4, CYP3A5, COMT, UGT2B7 or ABCB1...
April 4, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28379873/happy-despite-pain-a-randomized-controlled-trial-of-an-8-week-internet-delivered-positive-psychology-intervention-for-enhancing-well-being-in-patients-with-chronic-pain
#7
Madelon L Peters, Elke Smeets, Marion Feijge, Gerard van Breukelen, Gerhard Andersson, Monica Buhrman, Steven J Linton
OBJECTIVES: There is preliminary evidence for the efficacy of positive psychology interventions for pain management. The current study examined the effects of an internet-based positive psychology self-help program for patients with chronic musculoskeletal pain and compared it with an internet-based cognitive behavioural program. METHODS: A randomized controlled trial was carried out with three conditions: an internet-delivered positive psychology program, an internet-delivered cognitive behavioural program and waitlist control...
April 4, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28379872/patients-with-knee-osteoarthritis-who-score-highly-on-the-paindetect-questionnaire-present-with-multi-modality-hyperalgesia-increased-pain-and-impaired-physical-function
#8
Penny Moss, Heather A E Benson, Rob Will, Anthony Wright
OBJECTIVES: PainDETECT is a self-report questionnaire that can be used to identify features of neuropathic pain. A proportion of patients with knee osteoarthritis score highly on the PainDETECT questionnaire. This study aimed to determine whether those with a higher "positive neuropathic" score on the PainDETECT questionnaire also had greater pain, hypersensitivity and reduced function compared to individuals with knee OA with lower PainDETECT scores. METHODS: 130 participants with knee OA completed the PainDETECT, Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Pain Quality Assessment Scale (PQAS) questionnaires...
April 4, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28328700/lumbar-tactile-acuity-in-patients-with-low-back-pain-and-healthy-controls-systematic-review-and-meta-analysis
#9
Wacław Adamczyk, Kerstin Luedtke, Edward Saulicz
OBJECTIVE: Diminished tactile acuity in chronic non-neuropathic pain syndromes has been attributed to central pain processing and cortical reorganization. The latter was recently targeted in clinical trials that demonstrated no clear advantages over traditional approaches for the reduction of nonspecific low back pain (LBP). The aim of this systematic review and meta-analysis was to summarize the current evidence on tactile acuity in LBP and pain-free controls. METHODS: Six databases were independently searched by 2 researchers...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28328699/a-mindfulness-program-adapted-for-adolescents-with-chronic-pain-feasibility-acceptability-and-initial-outcomes
#10
Danielle A Ruskin, Michelle M Gagnon, Sara A Kohut, Jennifer N Stinson, Kathryn S Walker
OBJECTIVES: Pediatric chronic pain is a major health issue which can lead to significant interference in daily functioning. Mindfulness-based interventions (MBI's), which emphasize acceptance rather than control of pain, have gained increasing attention as a viable treatment option among adults with chronic pain. The effectiveness of MBIs for chronic pain in pediatric populations remains largely unknown. This prospective pre-post interventional study was conducted to examine the feasibility, acceptability, and initial effectiveness of an 8-week group MBI for adolescents (MBI-A) with chronic pain...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28328698/reduced-sufentanil-doses-are-effective-for-postoperative-analgesia-after-ductal-closure-in-extremely-premature-infants-a-10-years-retrospective-cohort-study
#11
Yohan Soreze, Etienne Audureau, Fabrice Decobert, Olivier Jaby, Sabine Blary, Claude Danan, Xavier Durrmeyer
OBJECTIVES: The objective of the study was to assess the efficacy of reduced sufentanil doses for postoperative analgesia following surgical ductal closure in extremely premature infants. METHODS: This was a retrospective, single-center, cohort study comparing 2 sufentanil dosing regimens used between 2001 and 2010 and included all infants born at <28 weeks of gestation with surgical ductal closure. Sufentanil doses were reduced in 2007 as a standard of care...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28328697/the-fear-avoidance-components-scale-facs-responsiveness-to-functional-restoration-treatment-in-a-chronic-musculoskeletal-pain-disorder-cmpd-population
#12
Randy Neblett, Tom G Mayer, Mark J Williams, Sali Asih, Antonio I Cuesta-Vargas, Meredith M Hartzell, Robert J Gatchel
OBJECTIVES: To assess the clinical validity and factor structure of the Fear-Avoidance Components Scale (FACS), a new fear-avoidance (FA) measure. METHODS: In this study, 426 chronic musculoskeletal pain disorder (CMPD) patients were admitted to a functional restoration program (FRP). They were categorized into five FACS severity levels, from Subclinical to Extreme, at admission, and again at discharge. Associations with objective lifting performance and other patient-reported psychosocial measures were determined at admission and discharge, and objective work outcomes for this predominantly disabled cohort, were assessed one-year later...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28277434/age-interactions-on-pain-sensitization-in-patients-with-severe-knee-osteoarthritis-and-controls
#13
Kristian Kjær Petersen, Lars Arendt-Nielsen, Sara Finocchietti, Rogerio Pessoto Hirata, Ole Simonsen, Mogens Berg Laursen, Thomas Graven-Nielsen
OBJECTIVES: Widespread pressure hyperalgesia, facilitated temporal summation of pain (TSP), and impaired conditioned pain modulation (CPM) have been found in knee osteoarthritis (KOA) patients compared with controls and these parameters have further been suggested to be altered in the elderly. This study investigated the influence of age on pressure hyperalgesia, TSP, and CPM in patients with KOA and controls. METHODS: One-hundred-thirty-three severe KOA patients and 50 age and sex-matched asymptomatic controls were assessed by cuff algometry and handheld pressure algometry...
March 8, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28272120/the-impact-of-serum-drug-concentration-on-the-efficacy-of-imipramine-pregabalin-and-their-combination-in-painful-polyneuropathy
#14
Søren H Sindrup, Jakob V Holbech, Flemming W Bach, Nanna B Finnerup, Kim Brøsen, Troels S Jensen
OBJECTIVE: The serum concentration-effect relation was explored for first line drugs in neuropathic pain and aimed to determine if efficacy could be increased. METHODS: Data from a randomized, placebo-controlled, cross-over trial on imipramine, pregabalin and their combination in painful polyneuropathy were used. Treatment periods were of 4 weeks' duration, outcome was the weekly median of daily pain rated by a 0-10 numeric scale, and drug concentrations were determined by high-performance liquid chromatography...
March 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28272119/obesity-moderates-the-effects-of-motivational-interviewing-treatment-outcomes-in-fibromyalgia
#15
Anthony S Kaleth, James E Slaven, Dennis C Ang
OBJECTIVE: Obesity is a common comorbid condition among patients with fibromyalgia (FM). Our objective was to assess if obesity moderates the treatment benefits of exercise-based motivational interviewing (MI) for FM. METHODS: This is a secondary data analysis of a completed clinical trial of 198 FM patients who were randomized to receive either MI or attention control (AC). Using body mass index (BMI) to divide participants into obese (BMI ≥30 kg/m) and non-obese (BMI <30 kg m) groups, mixed linear models were used to determine interaction between treatment arms and obesity status with regards to the primary outcome of global FM symptom severity (Fibromyalgia Impact Questionnaire, FIQ)...
March 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28272118/common-pediatric-pain-disorders-and-their-clinical-associations
#16
Theresa Donnelly, Aneeka Bott, Minh Bui, Shuxiang Goh, Tiina Jaaniste, Cindy Chapman, Matthew Crawford, John L Hopper, David Champion
BACKGROUND: Common childhood pain conditions (non-migraine headache, migraine, recurrent abdominal pain, growing pains, low back pain) and persistent pains are often associated with each other and have significant implications in later life. Emerging evidence suggests additional associations between these pain conditions and restless legs syndrome, iron deficiency, anxiety and depression. The aim of this cross-sectional study in pediatric twin individuals and their siblings was to investigate these associations...
March 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28272117/altered-functional-connectivity-in-sickle-cell-disease-exists-at-rest-and-during-acute-pain-challenge
#17
William T Zempsky, Michael C Stevens, James P Santanelli, Alexandra M Gaynor, Sabin Khadka
OBJECTIVES: Sickle cell disease (SCD) is a chronic pain disorder in which abnormally shaped red blood cells obstruct microcirculation causing ischemia and pain. The lack of SCD responsiveness to analgesics has led many to propose that nociceptive neural systems engaged when detecting pain become sensitized, resulting in an enhancement of pain response. METHODS: SCD patients and healthy controls were exposed to a painful stimuli of varying intensity using a pressure algometer and underwent several neuroimaging tasks...
March 7, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28244945/the-associated-factors-and-clinical-features-of-neuropathic-pain-after-brachial-plexus-injuries-a-cross-sectional-study
#18
Yingjie Zhou, Peixi Liu, Jing Rui, Xin Zhao, Jie Lao
INTRODUCTION: Neuropathic pain in patients with brachial plexus injuries brings complicated obstacles to the treatment and recovery for both surgeons and patients. OBJECTIVES: The clinical features of neuropathic pain, including pain intensity, type and time phase, need to be investigated. Moreover, possible associated factors need to be explored. METHODS: A cross-sectional study containing 77 participants was conducted. Their baseline information and injury-related conditions were collected...
February 27, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28244944/goals-of-chronic-pain-management-do-patients-and-primary-care-physicians-agree-and-does-it-matter
#19
Stephen G Henry, Robert A Bell, Joshua J Fenton, Richard L Kravitz
OBJECTIVE: Assess patient-physician agreement on management goals for chronic musculoskeletal pain and its associations with patient and physician visit experiences. MATERIALS AND METHODS: Previsit and postvisit questionnaires for 87 primary care visits involved patients taking opioids for chronic musculoskeletal pain and primary care residents. After each visit, patients and physicians independently ranked 5 pain treatment goals from most to least important. RESULTS: In total, 48% of patients ranked reducing pain intensity as their top priority, whereas 22% ranked finding a diagnosis as most important...
February 27, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28244943/mixed-pain-can-be-discerned-in-the-primary-care-and-orthopedics-settings-in-spain-a-large-cross-sectional-study
#20
Pedro J Ibor, Isabel Sánchez-Magro, Jesús Villoria, Ana Leal, Ana Esquivias
OBJECTIVES: To assess the value of the concept of mixed pain by investigating its acceptance and interpretation by health care professionals and the differential characteristics in patients with mixed pain. MATERIALS AND METHODS: Data from 5024 patients suffering pain from 551 sites in Primary Care and Orthopedics settings were analyzed in this cross-sectional study. Pain characteristics, other factors influencing pain, health care-related data and health-related quality of life were summarized and compared among 3 groups of patients according to the type of pain (nociceptive, neuropathic, or mixed), as assigned by the investigators after considering the pathophysiological mechanisms involved...
February 27, 2017: Clinical Journal of Pain
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