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Clinical Journal of Pain

Cynthia Kay, Joanne Bernstein, Nicole Fergestrom, Jeffrey L Jackson
OBJECTIVES: Overall opioid prescribing rates have decreased since 2012, but opioid-involved deaths have not. This study describes the regional and overall trends of opioid-related emergency department visits (EDVs) and hospitalizations of commercially insured patients on chronic opioids and those on concurrent opioids and benzodiazepines. METHODS: Secondary data analysis from Truven Health MarketScan Commercial Claims and Encounters (MarketScan) database from 2009-2015 was used...
August 14, 2018: Clinical Journal of Pain
Kathryn A Thompson, Hailey W Bulls, Kimberly T Sibille, Emily J Bartley, Toni L Glover, Ellen L Terry, Ivana A Vaughn, Josue S Cardoso, Adriana Sotolongo, Roland Staud, Laura B Hughes, Jeffrey C Edberg, David T Redden, Laurence A Bradley, Burel R Goodin, Roger B Fillingim
OBJECTIVES: This cross-sectional study examined the associations among optimism, psychological resilience, endogenous pain inhibition, and clinical knee pain severity. Two hypotheses were tested. First, we hypothesized that experimentally-tested endogenous pain inhibition would mediate the relationship between optimism and clinical knee pain severity. Secondly, it was also hypothesized that optimism would moderate the relationships of psychological resilience with endogenous pain inhibition and clinical knee pain severity, particularly for individuals with high optimism...
July 21, 2018: Clinical Journal of Pain
Marin Golčić, Renata Dobrila-Dintinjana, Goran Golčić, Ira Pavlović-Ružić, Lidija Gović-Golčić
OBJECTIVES: Unrelieved pain is present in a majority of terminal cancer patients. However, the treatment of pain in palliative and hospice care is affected by the lack of validated pain assessment. The goal of this study is to evaluate differences in pain evaluation between terminal cancer patients and physicians and evaluate the pain levels as a survival biomarker. METHODS: Patients were evaluated every 7 days for a total of 4 assessments. Physicians evaluated patients' pain on a NRS scale after clinical examination, after which the patients completed NRS, QLQ-C15-PAL, and ESAS questionnaires...
July 18, 2018: Clinical Journal of Pain
Amanda B Feinstein, John A Sturgeon, Rashmi P Bhandari, Isabel A Yoon, Alexandra Ross, Samantha Huestis, Anya Griffin, Laura Simons
OBJECTIVES: Both pediatric and parent pain catastrophizing and pain acceptance are key factors associated with pediatric pain outcomes; however, the interactive effects of these factors within the parent-child dyad have yet to be tested. The aims of this study were to examine: (1) the mediating role of child catastrophizing between parent catastrophizing and child outcomes (pain interference and mobility), (2) the mediating role of child acceptance between parent acceptance and child outcomes, and (3) whether child acceptance buffers the relation between parent catastrophizing and child catastrophizing, which in turn impacts child outcomes...
July 18, 2018: Clinical Journal of Pain
Zhi-Cao Yu, Lei Wen, Xing-Yong Shen, Hong-Mei Zhang
OBJECTIVES: Although previous studies have demonstrated that the OPRM1 A118G polymorphism may influence the analgesia response to cancer pain, the results are inconsistent. In this study, we aim to fully examine the association between OPRM1 A118G (rs1799971) polymorphism and the opioids analgesia by analyzing published information. This will provide information for better cancer pain management. METHODS: A systematic search of literatures dating to August 31 of 2017 was conducted, using PubMed, EMBase, Sinomed, and the Cochrane Library databases...
July 18, 2018: Clinical Journal of Pain
Basak Altıparmak, Çiğdem Güzel, Semra Gümüş Demirbilek
STUDY OBJECTIVE: The surgical trauma is known to induce hyperalgesia and if pain management is insufficient, it contributes to persistent pain in the postoperative period.In this study, our primary aims are to compare the effect of pregabalin and duloxetine on postoperative pain scores and cognitive functions. Our secondary aim is to determine drug-related side-effects. DESIGN: Prospective, randomized, double-blind, placebo-controlled. SETTINGS: Operating room, surgical ward...
July 16, 2018: Clinical Journal of Pain
Anne M Lynch-Jordan, James Peugh, Natoshia R Cunningham, Jessica R Trygier, Susmita Kashikar-Zuck
INTRODUCTION: A variety of factors influence parent responses to pain behaviors they observe in their adolescents with chronic pain. Certain parental responses to pain, such as attention or overprotection, can adversely impact adolescent adaptive functioning and correspond to poor clinical outcomes. OBJECTIVES: It was hypothesized that the relationship between adolescent pain behaviors and functional disability was mediated by maladaptive parenting (protective, monitoring, solicitousness) responses...
July 16, 2018: Clinical Journal of Pain
Carolina Sitges, Ana M González-Roldán, Stefan Duschek, Pedro Montoya
OBJECTIVES: Comorbid symptoms in fibromyalgia syndrome (FM), such as mood disorders and cognitive dysfunction, may lead to greater functional impairment than pain itself. This study aimed to unravel the modulating role of depression in response execution and inhibition in FM using an emotional go/no-go task. METHODS: Seventeen FM patients with low depression, 18 FM patients with high depression, and 18 pain-free subjects were selected. Pain, happy and neutral faces were pseudorandomly presented and subjects were asked to respond to male faces (go trials) by pressing a button, and to inhibit their responses if female faces were presented (no-go trials)...
July 2, 2018: Clinical Journal of Pain
Lisa V Doan, Jing Wang
OBJECTIVE: In the context of the current opioid epidemic, there has been a renewed interest in the use of ketamine as an analgesic agent. METHODS: We have reviewed ketamine analgesia. RESULTS: Ketamine is well-known as an antagonist for N-methyl-D-aspartate receptors. In addition, it can regulate the function of opioid receptors and sodium channels. Ketamine also increases signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors...
June 20, 2018: Clinical Journal of Pain
Peilong Dong, Xiaobo Tang, Rongrong Cheng, Jian Wang
BACKGROUND AND AIM: The severe pain after total knee arthroplasty (TKA) brings many patients more suffering, longer hospital stay and higher expenses. This study was designed to assess the relative efficacy of several clinical treatments for postoperative analgesia of TKA through network meta-analysis (NMA) based on multiple published randomized controlled trials. METHODS: Embase and PubMed were utilized to conduct this network meta-analysis from inception until 2016...
June 2, 2018: Clinical Journal of Pain
James Dunning, Raymond Butts, Ian Young, Firas Mourad, Victoria Galante, Paul Bliton, Michelle Tanner, César Fernández-de-Las-Peñas
OBJECTIVES: To compare the effects of adding electrical dry needling into a manual therapy and exercise program on pain, stiffness, function, and disability in individuals with painful knee osteoarthritis (OA). METHODS: Two hundred and forty-two participants (n=242) with painful knee OA were randomized to receive 6 weeks of electrical dry needling, manual therapy and exercise (n=121) or manual therapy and exercise (n=121). The primary outcome was related-disability as assessed by the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index at 3 months...
May 28, 2018: Clinical Journal of Pain
Keren Grinberg, Michal Granot, Lior Lowenstein, Liora Abramov, Irit Weissman-Fogel
OBJECTIVES: A patient's personal interpretations of a health threat or "illness perceptions" (IPs) are associated with their clinical outcomes. This study explored whether IPs are associated with pain severity and ability to modulate pain in women with chronic pelvic pain syndrome (CPPS), as well as the predictive value of IPs on Myofascial Physical Therapy (MPT) success. METHODS: Illness Perceptions Questionnaire - Revised (IPQ-R), mechanical and heat pain thresholds, mechanical temporal summation (mTS), and conditioned pain modulation (CPM) were evaluated in CPPS patients (n=39) before, and 3 months after MPT...
May 25, 2018: Clinical Journal of Pain
Maisa Ziadni, Dokyoung S You, Anna C Wilson, Beth D Darnall
OBJECTIVES: Social and interpersonal factors may impact chronic pain self-care and self-management; however, no integrated measure exists to assess the interplay of these factors. We developed and tested a measure designed to assess salient interpersonal factors, including relationship guilt and worry, and difficulty prioritizing self-care in chronic pain. METHODS: We tested self-report items broadly relevant to locus of care, limit-setting capacity, and worry/guilt about relationships in 3 discrete chronic pain samples (total N=1,452): (1) online sample of chronic pain clinic patients (N=729; 21 candidate CARE items, sociodemographics, and measures of psychological and physical functioning)...
September 2018: Clinical Journal of Pain
Alma Viviana Silva Guerrero, Annick Maujean, Letitia Campbell, Michele Sterling
OBJECTIVE: This systematic review and meta-analysis examined the effectiveness of physiotherapist delivered psychological interventions combined with physiotherapy on pain, disability, and psychological outcomes for patients with musculoskeletal pain conditions. METHODS: The review was conducted in accordance with the (PRISMA) guidelines. Five databases were systematically searched for randomized controlled trials from inception to May 2016. Studies were required to compare a psychological intervention delivered by physiotherapists combined with physiotherapy to physiotherapy alone or usual care...
September 2018: Clinical Journal of Pain
Yimin Wang, Fang Ye, Chanyan Huang, Faling Xue, Yingyuan Li, Shaowei Gao, Zeting Qiu, Si Li, Qinchang Chen, Huaqiang Zhou, Yiyan Song, Wenqi Huang, Wulin Tan, Zhongxing Wang
BACKGROUND: Neuropathic pain is one of the common complications after spinal cord injury (SCI), affecting individuals' quality of life. The molecular mechanism for neuropathic pain after SCI is still unclear. We aimed to discover potential genes and microRNAs (miRNAs) related to neuropathic pain by the bioinformatics method. METHODS: Microarray data of GSE69901 were obtained from Gene Expression Omnibus (GEO) database. Peripheral blood samples from individuals with or without neuropathic pain after SCI were collected...
September 2018: Clinical Journal of Pain
Marc Sorel, Jacques-Christian Beatrix, Blanche Locko, Catherine Armessen, Anne-Marie Domec, Otilia Lecompte, Sofiane Boucheneb, Benoit Harache, Jacques Robert, Jean-Pascal Lefaucheur
OBJECTIVES: The efficacy of ketamine in relieving complex regional pain syndrome (CRPS) lacks predictive factors. The value of three-phase bone scintigraphy (TPBS) was assessed for this purpose. MATERIALS AND METHODS: TPBS was performed in 105 patients with unilateral, focal CRPS of type 1 before 5 days of ketamine infusions. Tracer uptake was measured in the region of interest concerned by CRPS and the contralateral homologous region. For the 3 scintigraphic phases (vascular, tissular, and bone phases), an asymmetry ratio of fixation was calculated between the affected and the unaffected sides (vascular phase [VPr], tissular phase [TPr], and bone phase [BPr])...
September 2018: Clinical Journal of Pain
Justine Benoit-Piau, Sophie Bergeron, Audrey Brassard, Chantale Dumoulin, Samir Khalifé, Guy Waddell, Mélanie Morin
OBJECTIVE: To investigate the association between fear-avoidance variables, pelvic floor muscle (PFM) function, pain intensity in women with provoked vestibulodynia (PVD), as well as the moderator effect of partner support. MATERIALS AND METHODS: A sample of 173 women diagnosed with PVD participated in the study. Fear-avoidance variables were assessed with validated self-administered questionnaires: pain catastrophizing (Pain Catastrophizing Scale), pain-related fear (Pain Anxiety Symptoms Scale), and partner support (Partner Support Questionnaire)...
September 2018: Clinical Journal of Pain
Bin Mei, Gaige Meng, Guanghong Xu, Xinqi Cheng, Shishou Chen, Ye Zhang, Ming Zhang, Xuesheng Liu, Erwei Gu
BACKGROUND: Peripheral nerve block is a preferable method for elderly patients receiving hip arthroplasty. Sedation with dexmedetomidine may reduce postoperative delirium (POD). The aim of this study was to investigate whether intraoperative sedation with dexmedetomidine, as a supplementary to peripheral nerve block for elderly patients receiving total hip arthroplasty, can decrease the prevalence of POD. METHODS: A prospective, randomized controlled study was conducted with patients 65 years of age or older who underwent total hip arthroplasty between June 2016 and June 2017...
September 2018: Clinical Journal of Pain
Mark D Sullivan
OBJECTIVES: Treatment guidelines discourage long-term opioid treatment for patients with chronic pain and major depression, but this treatment occurs commonly, producing higher daily doses, longer duration, and more adverse events. MATERIALS AND METHODS: Review of prospective cohort, retrospective cohort, and other observational studies of the relation between depression and opioid use, abuse, and addiction. RESULTS: Depressed patients initiate opioid therapy slightly more often than nondepressed patients, but are twice as likely to transition to long-term use...
September 2018: Clinical Journal of Pain
Paola Indovina, Daniela Barone, Luigi Gallo, Andrea Chirico, Giuseppe De Pietro, Antonio Giordano
OBJECTIVES: This review aims to provide a framework for evaluating the utility of virtual reality (VR) as a distraction intervention to alleviate pain and distress during medical procedures. We first describe the theoretical bases underlying the VR analgesic and anxiolytic effects and define the main factors contributing to its efficacy, which largely emerged from studies on healthy volunteers. Then, we provide a comprehensive overview of the clinical trials using VR distraction during different medical procedures, such as burn injury treatments, chemotherapy, surgery, dental treatment, and other diagnostic and therapeutic procedures...
September 2018: Clinical Journal of Pain
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