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Clinical Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/30223112/colonic-microrna-profiles-identified-by-a-deep-learning-algorithm-that-predict-responses-of-patients-with-acute-severe-ulcerative-colitis-to-therapy
#1
Ian Morilla, Mathieu Uzzan, David Laharie, Dominique Cazals-Hatem, Quentin Denost, Fanny Daniel, Genevieve Belleannee, Yoram Bouhnik, Gilles Wainrib, Yves Panis, Eric Ogier-Denis, Xavier Treton
BACKGROUND & AIMS: Acute severe ulcerative colitis (ASUC) is a life-threatening condition managed with intravenous steroids followed by infliximab, cyclosporine, or colectomy (for patients with steroid resistance). There are no biomarkers to identify patients most likely to respond to therapy; ineffective medical treatment can delay colectomy and increase morbidity and mortality. We aimed to identify biomarkers of response to medical therapy for patients with ASUC. METHODS: We performed a retrospective analysis of 47 patients with ASUC, well characterized for their responses to steroids, cyclosporine, or infliximab, therapy at 2 centers in France...
September 14, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30218705/growing-retaining-an-endoscopy-nurse
#2
Catherine Bauer, Bryan G Sauer
No abstract text is available yet for this article.
September 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30218704/author-reply
#3
LETTER
Vincenzo La Mura, Massimo Primignani
No abstract text is available yet for this article.
September 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30218703/incorporating-advanced-practice-providers-into-gastroenterology-practice
#4
Monica Christine R Nandwani, John O Clarke
No abstract text is available yet for this article.
September 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30218702/primary-follicular-lymphoma-of-gallbladder-presenting-as-multiple-polyps
#5
Hyo Jung An, Woohyung Lee, Chi-Young Jeong
No abstract text is available yet for this article.
September 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30218701/innovating-in-your-practice-overcoming-barriers-to-create-new-opportunities
#6
V Raman Muthusamy, Srinadh Komanduri
No abstract text is available yet for this article.
September 12, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30217513/combined-celiac-ganglia-and-plexus-neurolysis-shortens-survival-without-benefit-vs-plexus-neurolysis-alone
#7
Michael J Levy, Ferga C Gleeson, Mark D Topazian, Larissa L Fujii-Lau, Felicity T Enders, Joseph J Larson, Kristin Mara, Barham K Abu Dayyeh, Steven R Alberts, Christopher L Hallemeier, Prasad G Iyer, Michael L Kendrick, William D Mauck, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Naoki Takahashi, Santhi S Vege, Kenneth K Wang, Suresh T Chari
BACKGROUND & AIMS: Pancreatic cancer produces debilitating pain that opioids often ineffectively manage. The suboptimal efficacy of celiac plexus neurolysis (CPN) might result from brief contact of the injectate with celiac ganglia. We compared the effects of endoscopic ultrasound-guided celiac ganglia neurolysis (CGN) vs the effects of CPN on pain, quality of life (QOL), and survival. METHODS: We performed a randomized, double-blind trial of patients with unresectable pancreatic ductal adenocarcinoma and abdominal pain; 60 patients (age 66...
September 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012432/obesity-and-weight-gain-are-associated-with-progression-of-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#8
Yejin Kim, Yoosoo Chang, Yong Kyun Cho, Jiin Ahn, Hocheol Shin, Seungho Ryu
BACKGROUND & AIMS: The effects of weight change on the progression of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in the general population are unclear. We evaluated the association of weight change and baseline body mass index (BMI) with fibrosis progression, determined by non-invasive measurement of a marker, in young and middle-aged adults with NAFLD. METHODS: We performed a prospective cohort study of 40,700 adults with NAFLD in Korea who received regular health screening examinations and were followed for a median 6...
September 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213587/incidence-of-progression-of-persistent-non-dysplastic-barrett-s-esophagus-to-malignancy
#9
Yonne Peters, Judith Honing, Wietske Kievit, Christine Kestens, Wiebe Pestman, Iris D Nagtegaal, Rachel S van der Post, Peter D Siersema
BACKGROUND & AIMS: The risk of esophageal adenocarcinoma (EAC) in patients with non-dysplastic Barrett's esophagus (NDBE) is low, so there is debate over the role of ongoing surveillance for patients with NDBE. It is important to identify patients at low risk for progression. We assessed cancer risk based on the subsequent number of endoscopies showing persistence of NDBE in a nationwide study in the Netherlands. METHODS: In a population-based study, patients with a first diagnosis of NDBE were selected from the Dutch nationwide registry of histopathology...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213586/is-low-level-viremia-acceptable-in-hepatitis-b-infected-patients-with-decompensation-on-antiviral-therapy
#10
EDITORIAL
Norah Terrault
No abstract text is available yet for this article.
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213585/cortico-anorectal-spino-anorectal-and-cortico-spinal-nerve-conduction-and-locus-of-neuronal-injury-in-patients-with-fecal-incontinence
#11
Xuelian Xiang, Tanisa Patcharatrakul, Amol Sharma, Rachael Parr, Shaheen Hamdy, Satish S C Rao
BACKGROUND & AIMS: The neuropathophysiology of fecal incontinence (FI) is incompletely understood. We examined the efferent brain-anorectal and spino-anorectal motor-evoked potentials (MEP) to characterize the locus of neuronal injury in patients with FI. METHODS: We performed bilateral transcranial, translumbar, and transsacral magnetic stimulations in 27 patients with FI (19 female) and 31 healthy individuals (controls, 20 female) from 2015 through 2017. MEPs were recorded simultaneously from the rectum and anus using 4 ring electrodes...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213584/efficacy-and-safety-of-induction-therapy-with-calcineurin-inhibitors-in-combination-with-vedolizumab-in-patients-with-refractory-ulcerative-colitis
#12
Gauthier Pellet, Carmen Stefanescu, Franck Carbonnel, Laurent Peyrin-Biroulet, Xavier Roblin, Christophe Allimant, Maria Nachury, Stephane Nancey, Jerome Filippi, Romain Altwegg, Hedia Brixi, Ginette Fotsing, Laure de Rosamel, Sarah Shili, David Laharie
BACKGROUND & AIMS: Vedolizumab is used to treat patients with ulcerative colitis (UC), although there is a delay before it is effective. Induction therapy with a calcineurin inhibitor (cyclosporine or tacrolimus) in combination with vedolizumab as maintenance therapy could be an option for patients with an active steroid-refractory UC. We assessed the efficacy and safety of this combination. METHODS: We performed a retrospective observational study, collecting data from 12 referral centers in France that were included in the Groupe d'Etude Thérapeutique des Affections Inflammatoires du tube Digestif...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213583/clinical-and-molecular-factors-associated-with-histologic-response-to-topical-steroid-treatment-in-patients-with-eosinophilic-esophagitis
#13
Swathi Eluri, Sara R Selitsky, Irina Perjar, Johnathan Hollyfield, Renee Betancourt, Cara Randall, Spencer Rusin, John T Woosley, Nicholas J Shaheen, Evan S Dellon
BACKGROUND AND AIMS: Few factors have been identified that can be used to predict response of patients with eosinophilic esophagitis (EoE) to topical steroid treatment. We aimed to determine whether baseline clinical, endoscopic, histologic, and molecular features of EoE can be used to predict histologic response. METHODS: We collected data from 97 patients with EoE, from 2009 through 2015, treated with a topical steroid for 8 weeks; 59 patients had a histologic response to treatment...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213582/numbers-and-features-of-patients-with-a-diagnosis-of-celiac-disease-without-duodenal-biopsy-based-on-a-national-survey
#14
Andrew M Joelson, Marilyn G Geller, Haley M Zylberberg, Peter H R Green, Benjamin Lebwohl
BACKGROUND & AIMS: According to guidelines, individuals with symptoms of celiac disease should undergo duodenal biopsy analysis to establish a diagnosis, but little is known about physician adherence to these guidelines. We used a patient-powered research network (PPRN) to compare demographics, diagnoses, symptoms, and treatment between groups of patients with celiac disease diagnosed by biopsy analysis and patients with a diagnosis based on results of serology tests. METHODS: We analyzed data from iCureCeliac-a voluntary, PPRN hosted and distributed by the Celiac Disease Foundation, from January 30, 2016 through August 25, 2016...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30213581/association-between-plasma-level-of-collagen-type-iii-alpha-1-chain-and-development-of-strictures-in-pediatric-patients-with-crohn-s-disease
#15
Cortney R Ballengee, Ryan W Stidham, Chunyan Liu, Mi-Ok Kim, Jarod Prince, Kajari Mondal, Robert Baldassano, Marla Dubinsky, James Markowitz, Neal Leleiko, Jeffrey Hyams, Lee Denson, Subra Kugathasan
BACKGROUND & AIMS: There are few serum biomarkers to identify patients with Crohn's disease (CD) who are at risk for stricture development. The extracellular matrix components, collagen type III alpha 1 chain (COL3A1) and cartilage oligomeric matrix protein (COMP), could contribute to intestinal fibrosis. We investigated whether children with inflammatory CD (B1) who later develop strictures (B2) have increased plasma levels of COL3A1 or COMP at diagnosis, compared to children who remain B1...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012435/efficacy-and-pharmacokinetics-of-glecaprevir-and-pibrentasvir-with-concurrent-use-of-acid-reducing-agents-in-patients-with-chronic-hcv-infection
#16
Steven Flamm, K Rajender Reddy, Neddie Zadeikis, Tarek Hassanein, Bruce R Bacon, Andreas Maieron, Stefan Zeuzem, Marc Bourliere, Jose L Calleja, Matthew P Kosloski, Rajneet K Oberoi, Chih-Wei Lin, Yao Yu, Sandra Lovell, Dimitri Semizarov, Federico J Mensa
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) are commonly prescribed to treat acid-related disorders. Some direct-acting antiviral regimens for chronic hepatitis C virus (HCV) infection have reduced efficacy in patients taking concomitant acid-reducing agents, including PPIs, due to interactions between drugs. We analyzed data from 9 multicenter, phase 2 and 3 trials to determine the efficacy and pharmacokinetics of an HCV therapeutic regimen comprising glecaprevir and pibrentasvir (glecaprevir/pibrentasvir) in patients taking concomitant acid-reducing agents...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012431/tofacitinib-induction-therapy-reduces-symptoms-within-3-days-for-patients-with-ulcerative-colitis
#17
Stephen Hanauer, Remo Panaccione, Silvio Danese, Adam Cheifetz, Walter Reinisch, Peter D R Higgins, Deborah A Woodworth, Haiying Zhang, Gary S Friedman, Nervin Lawendy, Daniel Quirk, Chudy I Nduaka, Chinyu Su
BACKGROUND & AIMS: Tofacitinib is an oral, small molecule inhibitor of JAK for the treatment of ulcerative colitis (UC). We evaluated the onset of symptom improvement in post-hoc analyses of data from 2 phase 3 trials of induction therapy with tofacitinib in patients with UC (OCTAVE Induction 1 and 2). METHODS: The studies comprised patients with moderate to severe active UC who were intolerant to, or failed by previous treatment with, corticosteroids, thiopurines, and/or tumor necrosis factor (TNF) antagonists...
September 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30201597/cost-effectiveness-of-universal-screening-for-hcv-infection-in-the-era-of-direct-acting-pangenotypic-treatment-regimens
#18
Mark H Eckman, John W Ward, Kenneth E Sherman
BACKGROUND & AIMS: Most persons infected with hepatitis C virus (HCV) in the United States (US) were born from 1945 through 1965-testing is recommended for this cohort. However, HCV incidence is increasing among younger persons in many parts of the country and treatment is recommended for all adults with HCV infection. We aimed to estimate the cost effectiveness of universal 1-time screening for HCV infection in all adults living in the US and to determine the prevalence of HCV antibody above which HCV testing is cost-effective...
September 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30201596/double-balloon-enteroscopy-assisted-diagnosis-of-malignancy-arising-from-meckel-s-diverticulum
#19
Smriti, Alan, Amit
No abstract text is available yet for this article.
September 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30201595/gastric-kaposi-sarcoma
#20
Stephanie Stephanie, Benjamin Mckinney, Erik C von Rosenvinge
No abstract text is available yet for this article.
September 7, 2018: Clinical Gastroenterology and Hepatology
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