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Clinical Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/30641144/holding-gastroenterologists-accountable-for-colonoscopy-through-macra-episode-based-cost-measure
#1
Shazia Mehmood Siddique, Shivan J Mehta
No abstract text is available yet for this article.
January 11, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30639779/validation-of-chronic-liver-disease-questionnaire-for-non-alcoholic-steatohepatitis-in-patients-with-biopsy-proven-non-alcoholic-steatohepatitis
#2
Zobair M Younossi, Maria Stepanova, Issah Younossi, Andrei Racila
BACKGROUND & AIMS: The chronic liver disease questionnaire for non-alcoholic steatohepatitis (CLDQ-NASH) was developed in a systematic manner for assessment of patient-reported outcomes. This instrument collects data on 36 items grouped into 6 domains: abdominal symptoms, activity/energy, emotional health, fatigue, systemic symptoms, and worry. We aimed to validate CLDQ-NASH in a large group of patients with NASH. METHODS: We collected data from patients with biopsy-proven NASH enrolled in 2 international phase 3 trials of selonsertib (NCT03053050 and NCT03053063)...
January 10, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30639778/progression-of-untreated-minimally-active-chronic-hbv-infection-compared-to-inactive-infection
#3
Hye Won Lee, Seung Up Kim, Baatarkhuu Oidov, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Beom Kyung Kim
No abstract text is available yet for this article.
January 10, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30639777/reply-to-dr-palmer
#4
LETTER
Sarah Ballou
No abstract text is available yet for this article.
January 10, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30639776/giant-fecaloma-causing-anorexia-and-dysuria
#5
Masahiro Yamasaki, Kunihiko Funaishi, Noboru Hattori
No abstract text is available yet for this article.
January 10, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30630104/improved-definition-of-hbv-phenotypes-based-on-genotype-specific-levels-of-hepatitis-b-s-antigen
#6
Willem P Brouwer, Qian Zhao, Bettina E Hansen, Daryl Lau, Mandana Khalili, Norah A Terrault, Adrian M Di Bisceglie, Robert P Perrillo, Michael W Fried, David Wong, Jordan J Feld, Steven H Belle, Harry L A Janssen
No abstract text is available yet for this article.
January 7, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30630103/outcomes-of-patients-with-inflammatory-bowel-diseases-switched-from-maintenance-therapy-with-a-biosimilar-to-remicade
#7
Akos Ilias, Kata Szanto, Lorant Gonczi, Zsuzsanna Kurti, Petra Anna Golovics, Klaudia Farkas, Eszter Schafer, Zoltan Szepes, Balázs Szalay, Aron Vincze, Tamas Szamosi, Tamas Molnar, Peter Laszlo Lakatos
BACKGROUND & AIMS: There is evidence that it is safe and effective for patients with inflammatory bowel diseases (IBD) to switch from maintenance therapy with an original infliximab drug to a biosimilar, but little is known about outcomes of reverse switches and/or multiple switches. We aimed to evaluate the effects of a reverse switch (from a biosimilar to Remicade) in a real-life cohort. METHODS: We performed a prospective observational study of 174 unselected and consecutive patients with IBD (136 with Crohn's disease [CD] and 38 with ulcerative colitis [UC]) who received maintenance therapy with the biosimilar in Hungary...
January 7, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30630102/cytologic-analysis-of-pancreatic-juice-increases-specificity-of-detection-of-malignant-ipmn-a-systematic-review
#8
REVIEW
Masayuki Tanaka, Max Heckler, Bing Liu, Ulrike Heger, Thilo Hackert, Christoph W Michalski
BACKGROUND & AIMS: Intraductal papillary mucinous neoplasms of the pancreas (IPMN) can progress to cancer. Biomarkers have been identified that were reported to increase the accuracy of identification of malignant lesions-we performed systematic review of the accuracy of these markers. METHODS: We performed a systematic review of published studies on biomarkers of malignant IPMNs by searching MEDLINE and Web of Science databases from January 2005 through December 2017...
January 7, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30630101/bridging-gaps-in-evidence-based-clinical-practice-in-inflammatory-bowel-diseases-observational-comparative-effectiveness-research-for-the-win
#9
EDITORIAL
Frank I Scott, Siddharth Singh
No abstract text is available yet for this article.
January 7, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625408/shorter-disease-duration-is-associated-with-higher-rates-of-response-to-vedolizumab-in-patients-with-crohn-s-disease-but-not-ulcerative-colitis
#10
David M Faleck, Adam Winters, Shreya Chablaney, Preeti Shashi, Joseph Meserve, Aaron Weiss, Satimai Aniwan, Jenna L Koliani-Pace, Gursimran Kochhar, Brigid Boland, Siddharth Singh, Robert Hirten, Eugenia Shmidt, Varun Kesar, Karen Lasch, Michelle Luo, Matthew Bohm, Sashidhar Varma, Monika Fischer, David Hudesman, Shannon Chang, Dana Lukin, Keith Sultan, Arun Swaminath, Nitin Gupta, Corey A Siegel, Bo Shen, William J Sandborn, Sunanda Kane, Edward V Loftus, Bruce E Sands, Jean-Frederic Colombel, Parambir S Dulai, Ryan Ungaro
BACKGROUND & AIMS: Patients with Crohn's disease (CD), but not ulcerative colitis (UC), of shorter duration have higher rates of response to tumor necrosis factor (TNF) antagonists than patients with longer disease duration. Little is known about the association between disease duration and response to other biologic agents. We aimed to evaluate response of patients with CD or UC to vedolizumab, stratified by disease duration. METHODS: We analyzed data from a retrospective, multicenter, consortium of patients with CD (n=650) or UC (n=437) treated with vedolizumab from May 2014 through December 2016...
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625407/substantial-increase-in-anesthesia-assistance-for-outpatient-colonoscopy-and-associated-cost-nationwide
#11
Anna Krigel, Ling Chen, Jason D Wright, Benjamin Lebwohl
BACKGROUND AND AIMS: The use of anesthesia assistance (AA) for outpatient colonoscopy has been increasing over the past decade, raising concern over its effects on procedure safety, quality, and cost. We performed a nationwide claims-based study to determine regional, patient-related, and facility-related patterns of anesthesia use as well as cost implications of AA for payers. METHODS: We analyzed the Premier Perspective database to identify patients undergoing outpatient colonoscopy at over 600 acute-care hospitals throughout the United States from 2006 through 2015, with or without AA...
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625406/bowel-cleansing-strategies-after-suboptimal-bowel-preparation
#12
Ala I Sharara, Halim Bou Daher
No abstract text is available yet for this article.
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625405/primary-pedunculated-solid-teratoma-of-the-rectum
#13
Tetsuya Yoshizaki, Yasuhiro Aoki, Akihiko Okada
No abstract text is available yet for this article.
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625404/patients-with-signs-of-advanced-liver-disease-and-clinically-significant-portal-hypertension-do-not-necessarily-have-cirrhosis
#14
Susana G Rodrigues, Matteo Montani, Sergi Guixé-Muntet, Andrea De Gottardi, Annalisa Berzigotti, Jaime Bosch
BACKGROUND & AIMS: Patients with hepatic venous pressure gradients (HVPGs) ≥10 mmHg and chronic liver disease are often assumed to have cirrhosis. We investigated the association between HVPGs and cirrhosis, using histologic findings as the reference standard. We also assessed the prevalence and characteristics of patients with HVPGs ≥10 mmHg without cirrhosis. METHODS: We performed a retrospective analysis of 157 consecutive patients, 89 with suspected cirrhosis and hepatic hemodynamic data collected from 2015 through 2017...
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625403/end-of-the-road-for-epinephrine-spraying-of-the-papilla-to-prevent-post-ercp-pancreatitis
#15
EDITORIAL
Mark A Gromski, Evan L Fogel
No abstract text is available yet for this article.
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625402/predniso-lo-ne-dosage-and-chance-of-remission-in-patients-with-autoimmune-hepatitis
#16
Simon Pape, Tom J G Gevers, Michail Belias, Ilyas F Mustafajev, Jan Maarten Vrolijk, Bart van Hoek, Gerd Bouma, Carin M J van Nieuwkerk, Johannes Hartl, Christoph Schramm, Ansgar W Lohse, Richard Taubert, Elmar Jaeckel, Michael P Manns, Maria Papp, Felix Stickel, Michael A Heneghan, Joost P H Drenth
BACKGROUND & AIMS: Patients with autoimmune hepatitis (AIH) commonly receive induction therapy with predniso(lo)ne followed by maintenance therapy with azathioprine. European Association for Study of the Liver clinical practice guidelines advise a predniso(lo)ne dose range of 0.50-1 mg/kg/day, which leaves room for practice variation. We performed a multicenter study to determine the efficacy of different dose ranges of predniso(lo)ne induction therapy in a large European cohort of patients with AIH...
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625401/tofacitinib-a-jak-of-all-trades
#17
EDITORIAL
Kristin E Burke, Ashwin N Ananthakrishnan
No abstract text is available yet for this article.
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30625400/statin-use-after-diagnosis-of-hepatocellular-carcinoma-and-patient-survival-findings-from-a-retrospective-cohort-study
#18
Aaron P Thrift, Yamini Natarajan, Yan Liu, Hashem B El-Serag
BACKGROUND & AIMS: Statin use is associated with lower risk of developing hepatocellular carcinoma (HCC). However, it is unclear whether post-diagnosis statin use is associated with reduced risk of mortality in HCC patients. METHODS: We used data from 15,422 patients with HCC in the VA Central Cancer Registry diagnosed between 2002 and 2016. We identified statin prescriptions that were filled before and after cancer diagnosis, and used time-dependent Cox regression models to calculate adjusted hazard ratios (HR) and 95% CIs for mortality risk...
January 5, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30616027/diagnostic-accuracy-of-non-invasive-fibrosis-models-to-detect-change-in-fibrosis-stage
#19
M Shadab Siddiqui, Goro Yamada, Raj Vuppalanchi, Mark Van Natta, Rohit Loomba, Cynthia Guy, Danielle Brandman, James Tonanscia, Naga Chalasani, Brent Neuschander-Tetri, Arun J Sanyal
BACKGROUND & AIMS: Noninvasive methods are needed to determine disease stage in patients with nonalcoholic fatty liver disease (NAFLD). We evaluated the diagnostic performance of several widely available fibrosis models for the assessment of hepatic fibrosis in patients with NAFLD. METHODS: We performed a retrospective analysis of data from individuals enrolled in the NIDDK NASH Clinical Research Network, from 2004 through 2018. Using biopsy as the reference standard, we determined the diagnostic performance of the aspartate aminotransferase (AST):platelet ratio (APRI), FIB-4, ratio of AST:alanine aminotransferase (ALT) and the NAFLD fibrosis score (NFS) in a cross-sectional study of 1904 subjects...
January 4, 2019: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30616026/negative-events-during-adulthood-are-associated-with-symptom-severity-and-altered-stress-response-in-patients-with-irritable-bowel-syndrome
#20
Colleen H Parker, Bruce D Naliboff, Wendy Shih, Angela P Presson, Elizabeth J Videlock, Emeran A Mayer, Lin Chang
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is a stress-sensitive disorder associated with dysregulation of the hypothalamic-pituitary-adrenal pathway. We studied the cumulative effect of events during adulthood on this pathway in patients with IBS. METHODS: We studied 129 patients with IBS, based on Rome III criteria (mean age 28.1 years, 66% women), and 108 healthy individuals (controls; mean age 29.8 years, 60% women) who completed the Life Experiences Survey from August 2013 to September 2017...
January 4, 2019: Clinical Gastroenterology and Hepatology
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