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Clinical Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/30012436/risk-of-bias-analysis-of-systematic-reviews-of-probiotics-for-treatment-of-irritable-bowel-syndrome
#1
Jordan Shapiro, Jessica Bernica, Ruben Hernaez
No abstract text is available yet for this article.
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012435/efficacy-and-pharmacokinetics-of-glecaprevir-and-pibrentasvir-with-concurrent-use-of-acid-reducing-agents-in-patients-with-chronic-hcv-infection
#2
Steven Flamm, K Rajender Reddy, Neddie Zadeikis, Tarek Hassanein, Bruce R Bacon, Andreas Maieron, Stefan Zeuzem, Marc Bourliere, Jose L Calleja, Matthew P Kosloski, Rajneet K Oberoi, Chih-Wei Lin, Yao Yu, Sandra Lovell, Dimitri Semizarov, Federico J Mensa
BACKGROUND & AIMS: Proton pump inhibitors (PPIs) are commonly prescribed to treat acid-related disorders. Some direct-acting antiviral regimens for chronic hepatitis C virus (HCV) infection have reduced efficacy in patients taking concomitant acid-reducing agents, including PPIs, due to interactions between drugs. We analyzed data from 9 multicenter, phase 2 and 3 trials to determine the efficacy and pharmacokinetics of an HCV therapeutic regimen comprising glecaprevir and pibrentasvir (glecaprevir/pibrentasvir) in patients taking concomitant acid-reducing agents...
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012434/is-biology-or-the-endoscopist-to-blame-for-post-colonoscopy-colorectal-cancer
#3
EDITORIAL
David Lieberman
No abstract text is available yet for this article.
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012433/lower-annual-rate-of-progression-of-short-segment-vs-long-segment-barrett-s-esophagus-to-esophageal-adenocarcinoma
#4
Nour Hamade, Sreekar Vennelaganti, Sravanthi Parasa, Prashanth Vennalaganti, Srinivas Gaddam, Manon C W Spaander, Sophie H van Olphen, Prashanthi N Thota, Kevin F Kennedy, Marco J Bruno, John J Vargo, Sharad Mathur, Brooks D Cash, Richard Sampliner, Neil Gupta, Gary W Falk, Ajay Bansal, Patrick E Young, David A Lieberman, Prateek Sharma
BACKGROUND & AIMS: European guidelines recommend different surveillance intervals of non-dysplastic Barrett's esophagus (NDBE) based on segment length, as opposed to guidelines in the United States, which do recommend surveillance intervals based on BE length. We studied rates of progression of NDBE to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in patients with short-segment BE using the definition of BE in the latest guidelines (length ≥1 cm). METHODS: We collected demographic, clinical, endoscopy, and histopathology data from 1883 patients with endoscopic evidence of NDBE (mean age, 57...
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012432/obesity-and-weight-gain-are-associated-with-progression-of-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#5
Yejin Kim, Yoosoo Chang, Yong Kyun Cho, Jiin Ahn, Hocheol Shin, Seungho Ryu
BACKGROUND & AIMS: The effects of weight change on the progression of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in the general population are unclear. We evaluated the association of weight change and baseline body mass index (BMI) with fibrosis progression, determined by non-invasive measurement of a marker, in young and middle-aged adults with NAFLD. METHODS: We performed a prospective cohort study of 40,700 adults with NAFLD in Korea who received regular health screening examinations and were followed for a median 6...
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012431/tofacitinib-induction-therapy-reduces-symptoms-within-3-days-for-patients-with-ulcerative-colitis
#6
Stephen Hanauer, Remo Panaccione, Silvio Danese, Adam Cheifetz, Walter Reinisch, Peter D R Higgins, Deborah A Woodworth, Haiying Zhang, Gary S Friedman, Nervin Lawendy, Daniel Quirk, Chudy I Nduaka, Chinyu Su
BACKGROUND & AIMS: Tofacitinib is an oral, small molecule inhibitor of JAK for the treatment of ulcerative colitis (UC). We evaluated the onset of symptom improvement in post-hoc analyses of data from 2 phase 3 trials of induction therapy with tofacitinib in patients with UC (OCTAVE Induction 1 and 2). METHODS: The studies comprised patients with moderate to severe active UC who were intolerant to, or failed by previous treatment with, corticosteroids, thiopurines, and/or tumor necrosis factor (TNF) antagonists...
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012430/treatments-for-crohn-s-disease-associated-bowel-damage-a-systematic-review
#7
REVIEW
Benjamin Pariente, Shurong Hu, Dominik Bettenworth, Silvia Speca, Pierre Desreumaux, Marie-Alice Meuwis, Silvio Danese, Florian Rieder, Edouard Louis
BACKGROUND & AIMS: Despite significant advances in the treatment of Crohn's disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic review of mechanisms and potential treatments for tissue damage lesions in CD patients. METHODS: We searched the PubMed, MBASE, and Cochrane databases from September 2016 through July 2017 for full-length articles on CD, fibrosis, damage lesions, mesenchymal stem cells, and/or treatment...
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30012429/obesity-is-independently-associated-with-higher-annual-burden-and-costs-of-hospitalization-in-patients-with-inflammatory-bowel-diseases
#8
Nghia H Nguyen, Lucila Ohno-Machado, William J Sandborn, Siddharth Singh
BACKGROUND AND AIMS: Approximately 15%-40% patients with inflammatory bowel diseases (IBD) are obese. There is an inconsistent association between obesity and IBD phenotype and course. We conducted a nationally representative cohort study to estimate and compare the burden, costs, and causes for hospitalization in obese vs. non-obese patients with IBD. METHODS: Using the Nationwide Readmissions Database 2013, we identified obese (based on administrative claims code) and non-obese patients who had been hospitalized at least once, from January through June 2013, and followed them for re-hospitalization until December 2013...
July 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30005974/organoaxial-volvulus
#9
Noah Wiedel, Jane Suh, Wuttiporn Manatsathit
No abstract text is available yet for this article.
July 10, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29990592/adding-value-to-the-conversation-about-colorectal-cancer-screening-practical-pearls-for-gastroenterologists
#10
Jennifer K Maratt, Keith Naylor, Sameer D Saini
No abstract text is available yet for this article.
July 7, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29981436/microscopic-colitis-a-rare-cause-of-pseudomembranes
#11
Robert J Schenck, Greg S Cohen, Maryam K Pezhouh
No abstract text is available yet for this article.
July 4, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29981435/calcifying-fibrous-tumor-of-small-bowel-causing-intussusception
#12
Sotiris Sotiriou, Theodosios Papavramidis, Prodromos Hytiroglou
No abstract text is available yet for this article.
July 4, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29981434/colonic-mass-in-a-patient-with-coagulopathy
#13
Grace Koo, Adam E Mikolajczyk, Sonia S Kupfer
No abstract text is available yet for this article.
July 4, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29966709/features-of-post-colonoscopy-colorectal-cancer-and-survival-times-of-patients-in-korea
#14
Jae Myung Cha, Hyun Soo Kim, Min Seub Kwak, Sohee Park, Geunu Park, Joo Sung Kim, Jie-Hyun Kim, Won Ho Kim
No abstract text is available yet for this article.
June 29, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29966708/evaluation-of-the-combined-variable-of-msi-and-braf-with-prognosis-in-colorectal-cancer
#15
EDITORIAL
Frank A Sinicrope
No abstract text is available yet for this article.
June 29, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29966707/high-high-resolution-anorectal-manometry-measures-are-more-accurate-than-conventional-measures-in-detecting-anal-hypocontractility-in-women-with-fecal-incontinence
#16
Emma V Carrington, Charles H Knowles, Ugo Grossi, S Mark Scott
BACKGROUND & AIMS: Anorectal manometry (ARM) is a common test of anal sphincter function. However, is has poor ability to detect differences in sphincter function between patients with vs without symptoms of fecal incontinence. We investigated whether new measures of anal resting and squeeze function, made by high-resolution anal manometry (HR-ARM), more accurately identify women with abnormal sphincter function that those derived from conventional ARM (C-ARM). METHODS: We performed a prospective study of 85 healthy female volunteers (median age, 41 years; range, 18-68 years) and 403 women with fecal incontinence (median age, 55; range, 18-91 years), analyzed by HR-ARM in the United Kingdom from June 2013 through December 2015...
June 29, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29966706/sclerosing-cholangitis-like-changes-on-magnetic-resonance-cholangiography-in-patients-with-drug-induced-liver-injury
#17
Jawad Ahmad, Simona Rossi, Shuchi K Rodgers, Marwan Ghabril, Robert J Fontana, Andrew Stolz, Paul H Hayashi, Huiman Barnhart, David E Kleiner, Einar S Bjornsson
Drug induced liver injury can lead to changes of the biliary tree that resemble sclerosing cholangitis. These changes can be seen on magnetic resonance cholangiopancreatography.
June 29, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29944926/effect-of-accelerated-infliximab-induction-on-short-and-long-term-outcomes-of-acute-severe-ulcerative-colitis-a-retrospective-multi-center-study-and-meta-analysis
#18
Niharika Nalagatla, Katherine Falloon, Gloria Tran, Nienke Z Borren, Danny Avalos, Jay Luther, Francis Colizzo, John Garber, Hamed Khalili, Joanna Melia, Matthew Bohm, Ashwin N Ananthakrishnan
BACKGROUND & AIMS: In patients with acute severe ulcerative colitis (ASUC), standard infliximab induction therapy has modest efficacy. There are limited data on the short-term or long-term efficacy of accelerated infliximab induction therapy for these patients. METHODS: In a retrospective study, we collected data from 213 patients with steroid refractory ASUC who received infliximab rescue therapy at 3 centers, from 2005 through 2017. Patients were classified that received standard therapy (5 mg/kg infliximab at weeks 0, 2, and 6) or accelerated therapy (>5 mg/kg infliximab at shorter intervals)...
June 23, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29935329/incidence-and-prevalence-of-pediatric-eosinophilic-esophagitis-in-utah-based-on-a-5-year-population-based-study
#19
Jacob Robson, Molly O'Gorman, Amber McClain, Krishna Mutyala, Cassandra Davis, Carlos Barbagelata, Justin Wheeler, Rafael Firszt, Ken Smith, Raza Patel, Kathryn Peterson, Amy Lowichik, Stephen Guthery
BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is often detected in children and is considered to be a rare disease, with prevalence values reported to be below 60 cases per 100,000 persons. To determine whether the incidence of EoE in children in Utah exceeds estimates from regional reports, we calculated incidence and prevalence values over a 5-year period. METHODS: Using consensus guidelines for the diagnosis of EoE, we reviewed pathology records from in the Intermountain Healthcare pathology database, from July 1, 2011 through June 31, 2016...
June 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29935328/assessment-of-liver-fibrosis-with-elastography-point-quantification-vs-other-non-invasive-methods
#20
Fabio Conti, Carla Serra, Ranka Vukotic, Cristina Felicani, Elena Mazzotta, Stefano Gitto, Giovanni Vitale, Antonietta D'Errico, Pietro Andreone
BACKGROUND & AIMS: Elastography point quantification (ElastPQ) is a non-invasive method for assessing liver fibrosis based on liver stiffness. We evaluated the accuracy of ElastPQ for the staging of liver fibrosis in patients with chronic liver disease (CLD) compared with aspartate transaminase to platelet ratio index, fibrosis-4 index, and transient elastography (TE), using liver biopsy as reference standard. METHODS: We performed a retrospective study of 406 patients with CLD of any etiology who underwent liver biopsy analysis from September 2012 through June 2017 at a clinic in Bologna, Italy...
June 20, 2018: Clinical Gastroenterology and Hepatology
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